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Erschienen in: Autoimmunity Highlights 1-2/2015

Open Access 01.08.2015 | Review Article

Automation, consolidation, and integration in autoimmune diagnostics

verfasst von: Renato Tozzoli, Federica D’Aurizio, Danilo Villalta, Nicola Bizzaro

Erschienen in: Autoimmunity Highlights | Ausgabe 1-2/2015

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Abstract

Over the past two decades, we have witnessed an extraordinary change in autoimmune diagnostics, characterized by the progressive evolution of analytical technologies, the availability of new tests, and the explosive growth of molecular biology and proteomics. Aside from these huge improvements, organizational changes have also occurred which brought about a more modern vision of the autoimmune laboratory. The introduction of automation (for harmonization of testing, reduction of human error, reduction of handling steps, increase of productivity, decrease of turnaround time, improvement of safety), consolidation (combining different analytical technologies or strategies on one instrument or on one group of connected instruments) and integration (linking analytical instruments or group of instruments with pre- and post-analytical devices) opened a new era in immunodiagnostics. In this article, we review the most important changes that have occurred in autoimmune diagnostics and present some models related to the introduction of automation in the autoimmunology laboratory, such as automated indirect immunofluorescence and changes in the two-step strategy for detection of autoantibodies; automated monoplex immunoassays and reduction of turnaround time; and automated multiplex immunoassays for autoantibody profiling.
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Metadaten
Titel
Automation, consolidation, and integration in autoimmune diagnostics
verfasst von
Renato Tozzoli
Federica D’Aurizio
Danilo Villalta
Nicola Bizzaro
Publikationsdatum
01.08.2015
Verlag
Springer International Publishing
Erschienen in
Autoimmunity Highlights / Ausgabe 1-2/2015
Print ISSN: 2038-0305
Elektronische ISSN: 2038-3274
DOI
https://doi.org/10.1007/s13317-015-0067-5

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