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01.12.2018 | Research article | Ausgabe 1/2018 Open Access

BMC Infectious Diseases 1/2018

Available, Bed-sided, Comprehensive (ABC) score to a diagnosis of Methicillin-resistant Staphylococcus aureus infection: a derivation and validation study

Zeitschrift:
BMC Infectious Diseases > Ausgabe 1/2018
Autoren:
Nori Yoshioka, Matsuo Deguchi, Hideharu Hagiya, Hisao Yoshida, Norihisa Yamamoto, Shoji Hashimoto, Yukihiro Akeda, Kazunori Tomono
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12879-017-2919-2) contains supplementary material, which is available to authorized users.

Abstract

Background

Methicillin-resistant Staphylococcus aureus (MRSA) infections continue to be a leading problem in health care facilities worldwide.

Methods

This single-center retrospective cohort study consisted of a derivation phase and a validation phase. The derivation phase included all patients admitted to Osaka University Hospital between May 2010 and April 2011. We proposed a provisional available, bed-sided, comprehensive (ABC) score, and evaluated its accuracy using the clinical diagnosis as a reference. We subsequently revised ABC scores based on k coefficient scores of each variable; this revision was validated by applying it to another patient population.

Results

A total of 172 patients and 154 cases were enrolled in the derivation and validation studies, respectively. The revised ABC score consisted of four simple variables: type of clinical specimen (1 to 3 points), Gram-staining result (1 point), presence of local inflammation (2 points), and a systemic inflammatory response (2 points). A revised score of ≥5 points was sensitive (93.8%) and specific (90.6%), and the area under the receiver-operating curve was 0.969 (95% CI; 0.957–1).

Conclusions

We developed a simple and comprehensive scoring system for diagnosis of nosocomial MRSA infections; this system is applicable in a wide variety of situations.
Zusatzmaterial
Additional file 1: The provisional ABC score. (PDF 52 kb)
12879_2017_2919_MOESM1_ESM.pdf
Additional file 2: Comparison of the two patient cohorts. (PDF 149 kb)
12879_2017_2919_MOESM2_ESM.pdf
Additional file 3: Clinical diagnosis associated with each specimen in the derivation cohort. (PDF 48 kb)
12879_2017_2919_MOESM3_ESM.pdf
Additional file 4: Evaluation of each subjects with scores applied. (PDF 100 kb)
12879_2017_2919_MOESM4_ESM.pdf
Additional file 5: Receiver operating characteristic curves for the provisional score of the derivation phase. (PDF 399 kb)
12879_2017_2919_MOESM5_ESM.pdf
Literatur
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