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Arthritis Research & Therapy

Erschienen in:

01.10.2003 | Review

B cell depletion in autoimmune disease

verfasst von: Claire Gorman, Maria Leandro, David Isenberg

Erschienen in: Arthritis Research & Therapy | Sonderheft 4/2003

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Abstract

The CD20 cell marker appears early in the process of B cell development. In this review we focus on the results of attempts to utilize B cell depletion based on the use of a chimeric monoclonal antibody (MAb) specific for human CD20, rituximab, for the treatment of patients with autoimmune diseases. In 1997, rituximab was approved for the treatment of low-grade B cell non-Hodgkin's lymphoma. Following these encouraging results, rituximab started to be used experimentally in other diseases presumed to be due to B cell pathology. The first autoimmune disease to be treated effectively was chronic idiopathic thrombocytopaenia. More recent success has been demonstrated in patients with rheumatoid arthritis and systemic lupus erythematosus.

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Titel: B cell depletion in autoimmune disease
verfasst von: Claire Gorman
Maria Leandro
David Isenberg
Publikationsdatum: 01.10.2003
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe Sonderheft 4/2003
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar1007

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