Skip to main content
Erschienen in: Rheumatology International 4/2010

01.02.2010 | Original Article

Back pain and sacroiliitis in long-standing adult celiac disease: a cross-sectional and follow-up study

Erschienen in: Rheumatology International | Ausgabe 4/2010

Einloggen, um Zugang zu erhalten

Abstract

There have been only scattered reports suggesting that musculoskeletal manifestations including back pain and sacroiliac joint involvement may be associated with celiac disease. In order to confirm this issue in a larger cohort, rheumatic manifestations were analyzed in 21 adult celiac patients using a comprehensive clinical, laboratory and radiological analysis. The diagnosis of celiac disease was based on the histopathology of jejunal biopsy specimens. The mean duration of celiac disease was 15 (0–31) years. All patients were currently on gluten-free diet and none of the patients had gastrointestinal symptoms at the time of the study. Using various imaging techniques, involvement of the sacroiliac joints was confirmed in 70% of celiac patients. Imaging revealed different morphological changes in the sacroiliac joint, e.g. accumulation of synovial fluid, synovitis, erosion with concomitant sclerosis, sacroiliitis or calcification of the ligament. These changes probably represent different clinical stages and/or manifestations of the same process. In a follow-up study of eight patients, after 11 years on a gluten-free diet, the great majority of patients had no clinical symptoms; yet, a subclinical progression of the sacroiliac joint involvement could be verified. Our results suggest the importance of regular rheumatologic follow-up of patients with celiac disease.
Literatur
1.
Zurück zum Zitat Kallikorn R, Uibo O, Uibo R (2000) Coeliac disease in spondylarthropathy: usefulness serological screen. Clin Rheumatol 19:118–122CrossRef Kallikorn R, Uibo O, Uibo R (2000) Coeliac disease in spondylarthropathy: usefulness serological screen. Clin Rheumatol 19:118–122CrossRef
2.
Zurück zum Zitat Collin P, Korpela M, Viander M et al (1992) Rheumatic complaints as a presenting symptom in patients with coeliac disease. Scand J Rheumatol 21:20–23CrossRefPubMed Collin P, Korpela M, Viander M et al (1992) Rheumatic complaints as a presenting symptom in patients with coeliac disease. Scand J Rheumatol 21:20–23CrossRefPubMed
4.
Zurück zum Zitat Slot O, Locht H (2000) Arthritis as presenting symptom in silent adult coeliac disease: two cases and review of the literature. Scand J Rheumatol 4:260–263 Slot O, Locht H (2000) Arthritis as presenting symptom in silent adult coeliac disease: two cases and review of the literature. Scand J Rheumatol 4:260–263
7.
Zurück zum Zitat Carbone MC, Pitzalis G, Ferri M, Nenna R, Thanasi E, Andreoli A, De Lorenzo A, Bonamico M (2003) Body composition in coeliac disease adolescents on gluten-free diet: a longitudinal study. Acta Diabetol 40:171–173. doi:10.1007/s00592-003-0057-3 CrossRef Carbone MC, Pitzalis G, Ferri M, Nenna R, Thanasi E, Andreoli A, De Lorenzo A, Bonamico M (2003) Body composition in coeliac disease adolescents on gluten-free diet: a longitudinal study. Acta Diabetol 40:171–173. doi:10.​1007/​s00592-003-0057-3 CrossRef
9.
Zurück zum Zitat The World Medical Association’s Declaration of Helsinki 1964 (2000) of ethical principles for medical research involving human subjects. Bull Med Ethics;162:8–11 or www.wma.net The World Medical Association’s Declaration of Helsinki 1964 (2000) of ethical principles for medical research involving human subjects. Bull Med Ethics;162:8–11 or www.​wma.​net
11.
Zurück zum Zitat Muche B, Bollw M, Francois RJ, Sieper J, Hamm B, Braun J (2003) Anatomic structure involved in early- and late-stage sacroiliitis in spondylarthritis: a detailed analysis by contrast-enhanced magnetic resonance imaging. Arthritis Rheum 5:1374–1384. doi:10.1002/art.10934 CrossRef Muche B, Bollw M, Francois RJ, Sieper J, Hamm B, Braun J (2003) Anatomic structure involved in early- and late-stage sacroiliitis in spondylarthritis: a detailed analysis by contrast-enhanced magnetic resonance imaging. Arthritis Rheum 5:1374–1384. doi:10.​1002/​art.​10934 CrossRef
12.
Zurück zum Zitat Puhakka KB, Jurik AG, Egond N, Schiottz-Christensen B et al (2003) Imaging of sacroiliitis in early seronegative spondylarthropathy: assessment of abnormalities by MR in comparison with radiography and CT. Acta Radiol 2:18–29 Puhakka KB, Jurik AG, Egond N, Schiottz-Christensen B et al (2003) Imaging of sacroiliitis in early seronegative spondylarthropathy: assessment of abnormalities by MR in comparison with radiography and CT. Acta Radiol 2:18–29
13.
Zurück zum Zitat el Maghraoui A, Lecoules S, Leehevaller D, Magnin J, Eurly F (1999) Acute sacroiliitis as a manifestation of calcium pyrophosphate dihydrate crystal deposition disease. Clin Exp Rheumatol 17(4):477–478PubMed el Maghraoui A, Lecoules S, Leehevaller D, Magnin J, Eurly F (1999) Acute sacroiliitis as a manifestation of calcium pyrophosphate dihydrate crystal deposition disease. Clin Exp Rheumatol 17(4):477–478PubMed
14.
Zurück zum Zitat Bezza A, Lechevalier D, Monreal M, el Maghraoui A, Magnin J, Eurly F (1999) L’at6teinte sacro-iliaque au cours de la maladie de Paget. Presse Med 28(22):1157–1159PubMed Bezza A, Lechevalier D, Monreal M, el Maghraoui A, Magnin J, Eurly F (1999) L’at6teinte sacro-iliaque au cours de la maladie de Paget. Presse Med 28(22):1157–1159PubMed
15.
Zurück zum Zitat Taccari E, Spadaro A, Sorgi ML, Sili Scavalli A (1992) Sacroiliac joint involvement in primary hyperthyroidism: pathogenic considerations. Clin Exp Rheumatol 3:263–265 Taccari E, Spadaro A, Sorgi ML, Sili Scavalli A (1992) Sacroiliac joint involvement in primary hyperthyroidism: pathogenic considerations. Clin Exp Rheumatol 3:263–265
16.
Zurück zum Zitat Resnich D, Niwayama G (1976) Subchongral resorption of bone in renal osteodystrophy. Radiology 118:315–321 Resnich D, Niwayama G (1976) Subchongral resorption of bone in renal osteodystrophy. Radiology 118:315–321
17.
Zurück zum Zitat Resnick D (1995) Diagnosis of bone and joint disorders, 3rd edn, vol 19. W.B. Saunders Company, Philadelphia, pp 106, 2015, 2022, 2030, 2033, 2061-2065 Resnick D (1995) Diagnosis of bone and joint disorders, 3rd edn, vol 19. W.B. Saunders Company, Philadelphia, pp 106, 2015, 2022, 2030, 2033, 2061-2065
Metadaten
Titel
Back pain and sacroiliitis in long-standing adult celiac disease: a cross-sectional and follow-up study
Publikationsdatum
01.02.2010
Erschienen in
Rheumatology International / Ausgabe 4/2010
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-009-0979-3

Weitere Artikel der Ausgabe 4/2010

Rheumatology International 4/2010 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.