Skip to main content
Erschienen in: European Radiology 1/2015

01.01.2015 | Nuclear Medicine

Background 99mTc-methoxyisobutylisonitrile uptake of breast-specific gamma imaging in relation to background parenchymal enhancement in magnetic resonance imaging

verfasst von: Hai-Jeon Yoon, Yemi Kim, Jee Eun Lee, Bom Sahn Kim

Erschienen in: European Radiology | Ausgabe 1/2015

Einloggen, um Zugang zu erhalten

Abstract

Objectives

This study investigated factors that could affect background uptake of 99mTc- methoxyisobutylisonitrile (MIBI) on normal breast by breast-specific gamma imaging (BSGI). In addition, the impact of background 99mTc-MIBI uptake on the diagnostic performance of BSGI was further investigated.

Methods

One hundred forty-five women with unilateral breast cancer who underwent BSGI, MRI, and mammography were retrospectively enrolled. Background uptake on BSGI was evaluated qualitatively and quantitatively. Patients were classified into non-dense and dense breast groups according to mammographic breast density. Background parenchymal enhancement (BPE) was rated according to BI-RADS classification. The relationship of age, menopausal status, mammographic breast density, and BPE with background 99mTc-MIBI uptake was analyzed.

Results

Heterogeneous texture and high background uptake ratio on BSGI were significantly correlated with younger age (p < 0.001, respectively), premenopausal status (p < 0.001 and p = 0.003), dense breast (p < 0.001, respectively), and marked BPE (p < 0.001, respectively). On multivariate analysis, only BPE remained a significant factor for background MIBI uptake (p < 0.001).There was a significant reduction in positive predictive value (p = 0.024 and p = 0.002) as background MIBI uptake and BPE grade increased.

Conclusions

BPE on MRI was the most important factor for background MIBI uptake on BSGI. High background MIBI uptake or marked BPE can diminish the diagnostic performance of BSGI.

Key Points

Age, menopause, density, and background parenchymal enhancement affect background MIBI uptake.
BPE is an independent factor for background MIBI uptake on BSGI.
Marked BPE may impair BSGI interpretation.
Literatur
1.
Zurück zum Zitat Okada RD, Glover D, Gaffney T, Williams S (1988) Myocardial kinetics of technetium-99 m-hexakis-2-methoxy-2-methylpropyl-isonitrile. Circulation 77:491–498PubMedCrossRef Okada RD, Glover D, Gaffney T, Williams S (1988) Myocardial kinetics of technetium-99 m-hexakis-2-methoxy-2-methylpropyl-isonitrile. Circulation 77:491–498PubMedCrossRef
2.
Zurück zum Zitat Ballinger J, Hua H, Berry B, Firby P, Boxen I (1995) 99Tcm-sestamibi as an agent for imaging P-glycoprotein-mediated multi-drug resistance: In vitro and in vivo studies in a rat breast tumour cell line and its doxirubicin-resistant variant. Nucl Med Commun 16:253–257PubMedCrossRef Ballinger J, Hua H, Berry B, Firby P, Boxen I (1995) 99Tcm-sestamibi as an agent for imaging P-glycoprotein-mediated multi-drug resistance: In vitro and in vivo studies in a rat breast tumour cell line and its doxirubicin-resistant variant. Nucl Med Commun 16:253–257PubMedCrossRef
3.
Zurück zum Zitat Delmon-Moingeon LI, Piwnica-Worms D, Van den Abbeele AD, Holman BL, Davison A, Jones AG (1990) Uptake of the cation hexakis (2-methoxyisobutylisonitrile)-technetium-99 m by human carcinoma cell lines in vitro. Cancer Res 50:2198–2202PubMed Delmon-Moingeon LI, Piwnica-Worms D, Van den Abbeele AD, Holman BL, Davison A, Jones AG (1990) Uptake of the cation hexakis (2-methoxyisobutylisonitrile)-technetium-99 m by human carcinoma cell lines in vitro. Cancer Res 50:2198–2202PubMed
4.
Zurück zum Zitat Aktolun C, Bayhan H, Kir M (1992) Clinical experience with Tc-99 m MIBI imaging in patients with malignant tumors preliminary results and comparison with TI-201. Clin Nucl Med 17:171–176PubMedCrossRef Aktolun C, Bayhan H, Kir M (1992) Clinical experience with Tc-99 m MIBI imaging in patients with malignant tumors preliminary results and comparison with TI-201. Clin Nucl Med 17:171–176PubMedCrossRef
5.
Zurück zum Zitat Brem RF, Floerke AC, Rapelyea JA, Teal C, Kelly T, Mathur V (2008) Breast-specific gamma imaging as an adjunct imaging modality for the diagnosis of breast cancer. Radiology 247:651–657PubMedCrossRef Brem RF, Floerke AC, Rapelyea JA, Teal C, Kelly T, Mathur V (2008) Breast-specific gamma imaging as an adjunct imaging modality for the diagnosis of breast cancer. Radiology 247:651–657PubMedCrossRef
6.
Zurück zum Zitat Goldsmith SJ, Parsons W, Guiberteau MJ et al (2010) SNM practice guideline for breast scintigraphy with breast-specific γ-cameras 1.0. J Nucl Med Technol 38:219–224PubMedCrossRef Goldsmith SJ, Parsons W, Guiberteau MJ et al (2010) SNM practice guideline for breast scintigraphy with breast-specific γ-cameras 1.0. J Nucl Med Technol 38:219–224PubMedCrossRef
7.
Zurück zum Zitat Lee CH, Dershaw DD, Kopans D et al (2010) Breast cancer screening with imaging: recommendations from the Society of Breast Imaging and the ACR on the use of mammography, breast MRI, breast ultrasound, and other technologies for the detection of clinically occult breast cancer. J Am Coll Radiol 7:18–27PubMedCrossRef Lee CH, Dershaw DD, Kopans D et al (2010) Breast cancer screening with imaging: recommendations from the Society of Breast Imaging and the ACR on the use of mammography, breast MRI, breast ultrasound, and other technologies for the detection of clinically occult breast cancer. J Am Coll Radiol 7:18–27PubMedCrossRef
8.
9.
Zurück zum Zitat Kolb TM, Lichy J, Newhouse JH (2002) Comparison of the performance of screening mammography, physical examination, and breast us and evaluation of factors that influence them: an analysis of 27,825 patient evaluations1. Radiology 225:165–175PubMedCrossRef Kolb TM, Lichy J, Newhouse JH (2002) Comparison of the performance of screening mammography, physical examination, and breast us and evaluation of factors that influence them: an analysis of 27,825 patient evaluations1. Radiology 225:165–175PubMedCrossRef
10.
Zurück zum Zitat Rosenberg RD, Hunt WC, Williamson MR et al (1998) Effects of age, breast density, ethnicity, and estrogen replacement therapy on screening mammographic sensitivity and cancer stage at diagnosis: review of 183,134 screening mammograms in Albuquerque, New Mexico. Radiology 209:511–518PubMedCrossRef Rosenberg RD, Hunt WC, Williamson MR et al (1998) Effects of age, breast density, ethnicity, and estrogen replacement therapy on screening mammographic sensitivity and cancer stage at diagnosis: review of 183,134 screening mammograms in Albuquerque, New Mexico. Radiology 209:511–518PubMedCrossRef
11.
Zurück zum Zitat White E, Velentgas P, Mandelson MT et al (1998) Variation in mammographic breast density by time in menstrual cycle among women aged 40–49 years. J Nati Cancer Inst 90:906–910CrossRef White E, Velentgas P, Mandelson MT et al (1998) Variation in mammographic breast density by time in menstrual cycle among women aged 40–49 years. J Nati Cancer Inst 90:906–910CrossRef
12.
13.
Zurück zum Zitat Baines CJ, Vidmar M, McKeown‐Eyssen G, Tibshirani R (1997) Impact of menstrual phase on false‐negative mammograms in the canadian national breast screening study. Cancer 80:720–724PubMedCrossRef Baines CJ, Vidmar M, McKeown‐Eyssen G, Tibshirani R (1997) Impact of menstrual phase on false‐negative mammograms in the canadian national breast screening study. Cancer 80:720–724PubMedCrossRef
14.
Zurück zum Zitat Hambly NM, Liberman L, Dershaw DD, Brennan S, Morris EA (2011) Background parenchymal enhancement on baseline screening breast MRI: impact on biopsy rate and short-interval follow-up. AJR 196:218–224PubMedCrossRef Hambly NM, Liberman L, Dershaw DD, Brennan S, Morris EA (2011) Background parenchymal enhancement on baseline screening breast MRI: impact on biopsy rate and short-interval follow-up. AJR 196:218–224PubMedCrossRef
15.
Zurück zum Zitat DeMartini WB, Liu F, Peacock S, Eby PR, Gutierrez RL, Lehman CD (2012) Background parenchymal enhancement on breast MRI: impact on diagnostic performance. AJR 198:W373–W380PubMedCrossRef DeMartini WB, Liu F, Peacock S, Eby PR, Gutierrez RL, Lehman CD (2012) Background parenchymal enhancement on breast MRI: impact on diagnostic performance. AJR 198:W373–W380PubMedCrossRef
16.
Zurück zum Zitat Müller-Schimpfle M, Ohmenhaüser K, Stoll P, Dietz K, Claussen CD (1997) Menstrual cycle and age: influence on parenchymal contrast medium enhancement in MR imaging of the breast. Radiology 203:145–149PubMedCrossRef Müller-Schimpfle M, Ohmenhaüser K, Stoll P, Dietz K, Claussen CD (1997) Menstrual cycle and age: influence on parenchymal contrast medium enhancement in MR imaging of the breast. Radiology 203:145–149PubMedCrossRef
17.
Zurück zum Zitat Kajihara M, Goto M, Hirayama Y et al (2013) Effect of the Menstrual Cycle on Background Parenchymal Enhancement in Breast MR Imaging. Magn Reson Med Sci 12:39–45PubMedCrossRef Kajihara M, Goto M, Hirayama Y et al (2013) Effect of the Menstrual Cycle on Background Parenchymal Enhancement in Breast MR Imaging. Magn Reson Med Sci 12:39–45PubMedCrossRef
18.
Zurück zum Zitat Delille JP, Slanetz PJ, Yeh ED, Kopans DB, Garrido L (2005) Physiologic changes in breast magnetic resonance imaging during the menstrual cycle: perfusion imaging, signal enhancement, and influence of the T1 relaxation time of breast tissue. Breast J 11:236–241PubMedCrossRef Delille JP, Slanetz PJ, Yeh ED, Kopans DB, Garrido L (2005) Physiologic changes in breast magnetic resonance imaging during the menstrual cycle: perfusion imaging, signal enhancement, and influence of the T1 relaxation time of breast tissue. Breast J 11:236–241PubMedCrossRef
19.
Zurück zum Zitat Koo HR, Moon WK, Chun IK et al (2013) Background < sup > 18</sup > F-FDG uptake in positron emission mammography (PEM): Correlation with mammographic density and background parenchymal enhancement in breast MRI. Eur J Radiol 82:1738–1742PubMedCrossRef Koo HR, Moon WK, Chun IK et al (2013) Background < sup > 18</sup > F-FDG uptake in positron emission mammography (PEM): Correlation with mammographic density and background parenchymal enhancement in breast MRI. Eur J Radiol 82:1738–1742PubMedCrossRef
20.
Zurück zum Zitat Cubuk R, Tasali N, Narin B, Keskiner F, Celik L, Guney S (2010) Correlation between breast density in mammography and background enhancement in MR mammography. Radiol Med 115:434–441PubMedCrossRef Cubuk R, Tasali N, Narin B, Keskiner F, Celik L, Guney S (2010) Correlation between breast density in mammography and background enhancement in MR mammography. Radiol Med 115:434–441PubMedCrossRef
21.
Zurück zum Zitat Ko ES, Lee BH, Choi HY, Kim RB, Noh W-C (2011) Background enhancement in breast MR: correlation with breast density in mammography and background echotexture in ultrasound. Eur J Radiol 80:719–723PubMedCrossRef Ko ES, Lee BH, Choi HY, Kim RB, Noh W-C (2011) Background enhancement in breast MR: correlation with breast density in mammography and background echotexture in ultrasound. Eur J Radiol 80:719–723PubMedCrossRef
22.
Zurück zum Zitat Kim BS, Moon BI, Cha ES (2012) A comparative study of breast-specific gamma imaging with the conventional imaging modality in breast cancer patients with dense breasts. Ann Nucl Med 26:823–829PubMedCrossRef Kim BS, Moon BI, Cha ES (2012) A comparative study of breast-specific gamma imaging with the conventional imaging modality in breast cancer patients with dense breasts. Ann Nucl Med 26:823–829PubMedCrossRef
24.
Zurück zum Zitat King V, Gu Y, Kaplan JB, Brooks JD, Pike MC, Morris EA (2012) Impact of menopausal status on background parenchymal enhancement and fibroglandular tissue on breast MRI. Eur Radiol 22:2641–2647PubMedCrossRef King V, Gu Y, Kaplan JB, Brooks JD, Pike MC, Morris EA (2012) Impact of menopausal status on background parenchymal enhancement and fibroglandular tissue on breast MRI. Eur Radiol 22:2641–2647PubMedCrossRef
25.
Zurück zum Zitat Kim MY, Choi N, Ko SM, Chung HW (2014) Background uptake of breast-specific gamma imaging: correlation with mammographic breast density and background enhancement of breast MRI. Clin Imaging. doi:10.1016/j.clinimag.2013.05.010 Kim MY, Choi N, Ko SM, Chung HW (2014) Background uptake of breast-specific gamma imaging: correlation with mammographic breast density and background enhancement of breast MRI. Clin Imaging. doi:10.​1016/​j.​clinimag.​2013.​05.​010
26.
Zurück zum Zitat Hegenscheid K, Schmidt CO, Seipel R et al (2012) Contrast enhancement kinetics of normal breast parenchyma in dynamic MR mammography: effects of menopausal status, oral contraceptives, and postmenopausal hormone therapy. Eur Radiol 22:2633–2640PubMedCrossRef Hegenscheid K, Schmidt CO, Seipel R et al (2012) Contrast enhancement kinetics of normal breast parenchyma in dynamic MR mammography: effects of menopausal status, oral contraceptives, and postmenopausal hormone therapy. Eur Radiol 22:2633–2640PubMedCrossRef
27.
Zurück zum Zitat Rechtman LR, Lenihan MJ, Lieberman JH et al (2014) Breast-Specific Gamma Imaging for the Detection of Breast Cancer in Dense Versus Nondense Breasts. AJR 202:293–298PubMedCrossRef Rechtman LR, Lenihan MJ, Lieberman JH et al (2014) Breast-Specific Gamma Imaging for the Detection of Breast Cancer in Dense Versus Nondense Breasts. AJR 202:293–298PubMedCrossRef
28.
Zurück zum Zitat Mavi A, Cermik TF, Urhan M et al (2010) The effect of age, menopausal state, and breast density on 18 F-FDG uptake in normal glandular breast tissue. J Nucl Med 51:347–352PubMedCrossRef Mavi A, Cermik TF, Urhan M et al (2010) The effect of age, menopausal state, and breast density on 18 F-FDG uptake in normal glandular breast tissue. J Nucl Med 51:347–352PubMedCrossRef
Metadaten
Titel
Background 99mTc-methoxyisobutylisonitrile uptake of breast-specific gamma imaging in relation to background parenchymal enhancement in magnetic resonance imaging
verfasst von
Hai-Jeon Yoon
Yemi Kim
Jee Eun Lee
Bom Sahn Kim
Publikationsdatum
01.01.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 1/2015
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3400-x

Weitere Artikel der Ausgabe 1/2015

European Radiology 1/2015 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.