Erschienen in:
23.10.2017 | Review Article
Bariatric Surgery Resistance: Using Preoperative Lifestyle Medicine and/or Pharmacology for Metabolic Responsiveness
verfasst von:
Nicole M. Gilbertson, Andrew S. Paisley, Sibylle Kranz, Arthur Weltman, Jennifer L. Kirby, Peter T. Hallowell, Steven K. Malin
Erschienen in:
Obesity Surgery
|
Ausgabe 12/2017
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Abstract
Bariatric surgery is an effective and durable treatment for individuals with obesity and its associated comorbidities. However, not all patients meet weight loss and/or cardiometabolic goals following bariatric surgery, suggesting that some people are bariatric surgery resistant. The reason for this resistance is unclear, but potential factors, such as adiposity-derived inflammation, insulin resistance, hyperglycemia, and aerobic fitness prior to surgery, have been related to blunted surgery responsiveness. Exercise, diet, and/or pharmacology are effective at reducing inflammation and improving insulin action as well as physical function. Herein, we present data that supports the novel hypothesis that intervening prior to surgery can enhance disease resolution in people who are resistant to bariatric surgery.