Basal or stimulated thyroglobulin in evaluating response to treatment in papillary thyroid carcinoma? A retrospective cohort study
- 28.11.2023
- Original Article
Erschienen in:
- Verfasst von
- Leticia Barreto
- Deborah Cristina Goulart Ferreira
- José Eduardo Corrente
- Carlos Segundo Paiva Soares
- Cristiano Claudino Oliveira
- Simone Antunes Terra
- Sonia Marta Moriguchi
- Katia Hiromoto Koga
- José Vicente Tagliarini
- Gláucia Maria Ferreira da Silva Mazeto
- Erschienen in
- Hormones | Ausgabe 1/2024
Abstract
Objective
It is not clear whether response to initial treatment in papillary thyroid carcinoma (PTC) patients is best evaluated by measuring thyroglobulin (Tg) in the presence of levothyroxine (BTg) or when stimulated by elevated TSH (STg). The aim of this study was to evaluate whether response to therapy 1 year after initial treatment changes with the use of STg in relation to BTg in PTC patients treated with total thyroidectomy (TT) and radioiodine (131I), and, if observed, to assess which response is better associated with clinical course.
Subjects and methods
This is a retrospective study of 148 PTC patients submitted to TT and 131I. We analyzed the response to therapy (excellent, biochemical incomplete, or indeterminate) at 1 year after initial treatment, using BTg or STg, and compared which method was better associated with “excellent response at final evaluation.”
Results
Twenty-eight patients (20.4%) presented change in response to therapy, with 17 of these (60.7%) presenting a worse response. Response using STg was 1.6 times better associated with proposed outcome [odds ratio (OR) = 4.61; confidence interval 95% (IC95%): 2.13–9.98] than with BTg (OR = 2.84; IC95%: 1.33–6.06).
Conclusion
Response to therapy at 1 year using STg was altered in approximately 20% of cases and therefore proved to be a better predictor of excellent response in the last evaluation.
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- Titel
- Basal or stimulated thyroglobulin in evaluating response to treatment in papillary thyroid carcinoma? A retrospective cohort study
- Verfasst von
-
Leticia Barreto
Deborah Cristina Goulart Ferreira
José Eduardo Corrente
Carlos Segundo Paiva Soares
Cristiano Claudino Oliveira
Simone Antunes Terra
Sonia Marta Moriguchi
Katia Hiromoto Koga
José Vicente Tagliarini
Gláucia Maria Ferreira da Silva Mazeto
- Publikationsdatum
- 28.11.2023
- Verlag
- Springer International Publishing
- Erschienen in
-
Hormones / Ausgabe 1/2024
Print ISSN: 1109-3099
Elektronische ISSN: 2520-8721 - DOI
- https://doi.org/10.1007/s42000-023-00503-0
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