The online version of this article (doi:10.1186/1752-1947-8-123) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
All authors contributed to the care of the patient and analyzed the data. ST used all of the data available and wrote the majority of this report. KY revised the manuscript. MK, TK, and AT saw the patient in hospital and contributed the case history notes used in this report. YT contributed to image production. YK reported and provided us with the histopathological findings and slides. TK and TT were consultant radiotherapists involved in the management of this patient. All authors read and approved the final manuscript.
Basaloid squamous cell carcinoma is a rare and aggressive variant of squamous cell carcinoma. Basaloid squamous cell carcinoma is mostly seen in the upper aerodigestive tract and has a propensity for lymph node spread and systemic metastases. Various treatment modalities have been reported, including surgical excision supplemented with radiotherapy/adjuvant chemotherapy. To the best of our knowledge, treatment of nasal basaloid squamous cell carcinoma with proton beam therapy and cisplatin has not been described in the literature.
We report the case of a 56-year-old Japanese man with locally invasive basaloid squamous cell carcinoma in his right nasal cavity with invasion of the orbit, paranasal sinus, and buccal subcutaneous tissue. He underwent proton beam therapy concurrent with cisplatin. Acute and late side effects did not exceed grade 3. At 24-month follow up, he remains in complete remission.
Proton beam therapy concurrent with cisplatin may be one choice for locally invasive basaloid squamous cell carcinoma.
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- Basaloid squamous cell carcinoma in the nasal cavity treated with proton beam therapy concurrent with cisplatin: a case report
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