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03.01.2019 | Thoracic Oncology | Ausgabe 3/2019

Annals of Surgical Oncology 3/2019

Baseline and Postoperative C-reactive Protein Levels Predict Long-Term Survival After Lung Metastasectomy

Annals of Surgical Oncology > Ausgabe 3/2019
MD Ugo Pastorino, MD Daniele Morelli, MD Giovanni Leuzzi, MD Luigi Rolli, BS Paola Suatoni, PhD Francesca Taverna, BL Elena Bertocchi, PhD Mattia Boeri, PhD Gabriella Sozzi, PhD Anna Cantarutti, PhD Giovanni Corrao, MD Alessandro Gronchi
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The online version of this article (https://​doi.​org/​10.​1245/​s10434-018-07116-7) contains supplementary material, which is available to authorized users.

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Blood level of C-reactive protein (CRP) at diagnosis is a well-know prognostic bio-marker in different primary tumors, but its role has not been investigated in resectable lung metastases. The aim of our study is to assess the predictive value of baseline (CRP0) and 3rd postoperative day (CRP3) levels on long-term survival of patients undergoing lung metastasectomy.


A total of 846 consecutive patients underwent the first pulmonary resection for lung metastases between January 2003 and December 2015, including 611 (72%) single surgical procedures, 235 (28%) multiple metastasectomies, 501 (59%) epithelial primary tumors, 276 (33%) sarcomas, 66 (8%) melanomas, 286 (33.8%) with 0 risk factors (CRP0 ≤ 2 and CRP3 ≤ 84 mg/L) and 560 (66.2%) with ≥ 1 risk factor (CRP0 > 2 and/or CRP3 > 84 mg/L).


Cumulative 5-year survival was 57% in patients with low CRP (0 risk factors) versus 43% in high CRP (≥ 1 risk factor, p < 0.0002), 62% versus 50% respectively for epithelial tumors (p < 0.0140), and 51% versus 34% for sarcomas (p < 0.0111). Multivariable Cox analysis confirmed a mortality hazard ratio of 2.5 at 1-year and 1.5 at 5-years in patients with high CRP.


Baseline and postoperative CRP levels predict survival of patients with resectable lung metastases. These data provide a rationale for prospective clinical trials testing the efficacy of anti-inflammatory or immune-modulating agents as “adjuvant” therapy after lung metastasectomy, in patients with elevated pre- and/or postoperative CRP levels.

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Fig. 1 Kaplan–Meier survival curves by number of metastasectomy (A. single, B. multiple), according to C-reactive protein measured at baseline (CRP0) and 3 days after surgery (CRP3). Low CRP: CRP0 ≤ 2 and CRP3 ≤ 84-high CRP: CRP0 > 2 or CRP3 > 84 (TIFF 974 kb)
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