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09.11.2017 | Brief Report

Baseline predictors of DMT reinitiation among patients with multiple sclerosis following an MI–CBT intervention

verfasst von: Joanie Thelen, Amanda Bruce, Delwyn Catley, Sharon Lynch, Kathy Goggin, Andrea Bradley-Ewing, Morgan Glusman, Abigail Norouzinia, Lauren Strober, Jared Bruce

Erschienen in: Journal of Behavioral Medicine | Ausgabe 2/2018

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Abstract

Patients with multiple sclerosis (MS) are often nonadherent to their disease modifying therapy (DMT). While recent studies demonstrate enhanced DMT adherence following intervention grounded in motivational interviewing (MI), little is known about how to address DMT reinitiation among MS patients who have prematurely discontinued DMT against medical advice and do not intend to reinitiate. We examined baseline predictors of DMT reinitiation among patients with MS who discontinued medications against medical advice following a telephone-based MI and Cognitive Behavioral Therapy (MI–CBT) intervention. Following MI–CBT intervention, 66 patients reported whether or not they opted to reinitiate DMT. Rate of disease progression (β = 0.295) and perceived personal control (β = − 0.131) emerged as unique significant predictors of DMT reinitiation following intervention. Clinical characteristics and health-related beliefs may be used to prospectively identify patients most likely to reinitiate DMT following MI–CBT intervention, furthering the goal of preserving brain health and preventing neurologic decline in MS via appropriate DMT utilization. Further study is warranted to delineate potential mediators and moderators of DMT reinitiation outcomes.

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Titel: Baseline predictors of DMT reinitiation among patients with multiple sclerosis following an MI–CBT intervention
verfasst von: Joanie Thelen
Amanda Bruce
Delwyn Catley
Sharon Lynch
Kathy Goggin
Andrea Bradley-Ewing
Morgan Glusman
Abigail Norouzinia
Lauren Strober
Jared Bruce
Publikationsdatum: 09.11.2017
Verlag: Springer US
Erschienen in: Journal of Behavioral Medicine / Ausgabe 2/2018
Print ISSN: 0160-7715
Elektronische ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-017-9900-9

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Baseline predictors of DMT reinitiation among patients with multiple sclerosis following an MI–CBT intervention

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