Ausgabe 6/2020
Inhalt (21 Artikel)
Interruption of vascular endothelial growth factor receptor 2 signaling induces a proliferative pulmonary vasculopathy and pulmonary hypertension
Max-Paul Winter, Smriti Sharma, Johanna Altmann, Veronika Seidl, Adelheid Panzenböck, Arman Alimohammadi, Thomas Zelniker, Bassam Redwan, Felix Nagel, David Santer, Alexander Stieglbauer, Bruno Podesser, Maria Sibilia, Thomas Helbich, Gerald Prager, Aysegül Ilhan-Mutlu, Matthias Preusser, Irene M. Lang
Intracellular O-linked glycosylation directly regulates cardiomyocyte L-type Ca2+ channel activity and excitation–contraction coupling
Andrew R. Ednie, Eric S. Bennett
Deletion of obscurin immunoglobulin domains Ig58/59 leads to age-dependent cardiac remodeling and arrhythmia
Alyssa Grogan, Andrew Coleman, Humberto Joca, Henk Granzier, Mark W. Russel, Christopher W. Ward, Aikaterini Kontrogianni-Konstantopoulos
A practical guide for investigating cardiac physiology using living myocardial slices
S. A. Watson, A. Dendorfer, T. Thum, F. Perbellini
Neuraminidase-1 promotes heart failure after ischemia/reperfusion injury by affecting cardiomyocytes and invading monocytes/macrophages
Maren Heimerl, Irina Sieve, Melanie Ricke-Hoch, Sergej Erschow, Karin Battmer, Michaela Scherr, Denise Hilfiker-Kleiner
Targeting myocardial ischaemic injury in the absence of reperfusion
M. V. Basalay, D. M. Yellon, S. M. Davidson
Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia
Nina Hagemann, Ayan Mohamud Yusuf, Carlotta Martiny, Xiaoni Zhang, Christoph Kleinschnitz, Matthias Gunzer, Richard Kolesnick, Erich Gulbins, Dirk M. Hermann
Autocrine effects of PCSK9 on cardiomyocytes
Annemarie Wolf, Hanna Sarah Kutsche, Rolf Schreckenberg, Martin Weber, Ling Li, Susanne Rohrbach, Rainer Schulz, Klaus-Dieter Schlüter
PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemia
Xianwei Wang, Xiao Li, Shijie Liu, Anna N. Brickell, Jinghang Zhang, Zekun Wu, Sichang Zhou, Zufeng Ding
Functional investigation of the coronary artery disease gene SVEP1
Michael J. Winkler, Philipp Müller, Amin M. Sharifi, Jana Wobst, Hanna Winter, Michal Mokry, Lijiang Ma, Sander W. van der Laan, Shichao Pang, Benedikt Miritsch, Julia Hinterdobler, Julia Werner, Barbara Stiller, Ulrich Güldener, Tom R. Webb, Folkert W. Asselbergs, Johan L. M. Björkegren, Lars Maegdefessel, Heribert Schunkert, Hendrik B. Sager, Thorsten Kessler
The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice
Mehreen Batool, Eva M. Berghausen, Mario Zierden, Marius Vantler, Ralph T. Schermuly, Stephan Baldus, Stephan Rosenkranz, Henrik ten Freyhaus
The importance of clinically relevant background therapy in cardioprotective studies
Zhenhe He, Sean M. Davidson, Derek M. Yellon
Genetic background influences expression and function of the cation channel TRPM4 in the mouse heart
Rebekka Medert, Andy Pironet, Lucas Bacmeister, Sebastian Segin, Juan E. Camacho Londoño, Rudi Vennekens, Marc Freichel
Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways
Bence Hegyi, Johanna M. Borst, Logan R. J. Bailey, Erin Y. Shen, Austen J. Lucena, Manuel F. Navedo, Julie Bossuyt, Donald M. Bers
Cellular and mitochondrial mechanisms of atrial fibrillation
Fleur E. Mason, Julius Ryan D. Pronto, Khaled Alhussini, Christoph Maack, Niels Voigt
Mouse models of atherosclerosis and their suitability for the study of myocardial infarction
Pelin Golforoush, Derek M. Yellon, Sean M. Davidson
Reduced reticulum–mitochondria Ca2+ transfer is an early and reversible trigger of mitochondrial dysfunctions in diabetic cardiomyopathy
Maya Dia, Ludovic Gomez, Helene Thibault, Nolwenn Tessier, Christelle Leon, Christophe Chouabe, Sylvie Ducreux, Noelle Gallo-Bona, Emily Tubbs, Nadia Bendridi, Stephanie Chanon, Aymeric Leray, Lucid Belmudes, Yohann Couté, Mazen Kurdi, Michel Ovize, Jennifer Rieusset, Melanie Paillard
Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes
Anastasia Kyselova, Amro Elgheznawy, Ilka Wittig, Juliana Heidler, Alexander W. Mann, Wolfram Ruf, Ingrid Fleming, Voahanginirina Randriamboavonjy
Tenascin C promotes valvular remodeling in two large animal models of ischemic mitral regurgitation
Ouafa Hamza, Attila Kiss, Anne-Margarethe Kramer, Sandra Trojanek, Dietmar Abraham, Eylem Acar, Felix Nagel, Verena Eva Tretter, Melitta Kitzwögerer, Bruno K. Podesser
Resident cardiac macrophages: crucial modulators of cardiac (patho)physiology
M. Sansonetti, F. J. G. Waleczek, M. Jung, T. Thum, F. Perbellini
Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering
Carmen Härdtner, Jan Kornemann, Katja Krebs, Carolin A. Ehlert, Alina Jander, Jiadai Zou, Christopher Starz, Simon Rauterberg, Diana Sharipova, Bianca Dufner, Natalie Hoppe, Tsai-Sang Dederichs, Florian Willecke, Peter Stachon, Timo Heidt, Dennis Wolf, Constantin von zur Mühlen, Josef Madl, Peter Kohl, Rafael Kaeser, Tobias Boettler, Elsbeth J. Pieterman, Hans M. G. Princen, Benoît Ho-Tin-Noé, Filip K. Swirski, Clinton S. Robbins, Christoph Bode, Andreas Zirlik, Ingo Hilgendorf