Skip to main content
Erschienen in:

27.06.2016 | Übersicht

Basophil activation testing in diagnosis and monitoring of allergic disease – an overview

verfasst von: Prof. Dr. Bernadette Eberlein, Alexandra F. Santos, Cristobalina Mayorga, Anna Nopp, Marta Ferrer, Paul Rouzaire, Didier Ebo, Vito Sabato, Maria L. Sanz, Tatjana Pecaric-Petkovic, Sarita U. Patil, Oliver V. Hausmann, Wayne G. Shreffler, Peter Korosec, Edward F. Knol, Hans Jürgen Hoffmann

Erschienen in: Allergo Journal | Ausgabe 4/2016

Einloggen, um Zugang zu erhalten

Abstract

The nature of basophil activation as an ex vivo challenge makes it a multifaceted and promising tool for the allergist. Through the development of flow cytometry, discovery of activation markers such as CD63 and markers identifying basophil granulocytes, the basophil activation test (BAT) has become a pervasive test. BAT measures basophil response to allergen crosslinking IgE on between 150 and 2,000 basophil granulocytes with remarkable analytical sensitivity in < 0.1 ml fresh blood. Dichotomous activation is assessed as the fraction of reacting basophils. In patients with food-, insect venom-, and drug allergy and patients with chronic urticaria BAT can be part of the diagnostic evaluation in addition to history, skin prick testing, and specific IgE determination. BAT may also be helpful in determining the clinically relevant allergen. Basophil sensitivity may be used to monitor patients on allergen immunotherapy, anti-IgE treatment, or in the natural resolution of allergy. The test may use fewer resources and be more reproducible than oral, sting, nasal or bronchial challenge testing. BAT may be useful before challenge testing as it is less stressful for the patient and avoids severe allergic reactions. It may be useful before challenge testing. An important next step is to standardize BAT and make it available in diagnostic laboratories. This article provides an overview of the practical and technical details as well as the utility of BAT in diagnosis and management of allergic diseases.
Literatur
1.
Zurück zum Zitat Knol EF, Mul FP, Jansen H, Calafat J, Roos D. Monitoring human basophil activation via CD63 monoclonal antibody 435. J Allergy Clin Immunol 1991;88:328–338CrossRefPubMed Knol EF, Mul FP, Jansen H, Calafat J, Roos D. Monitoring human basophil activation via CD63 monoclonal antibody 435. J Allergy Clin Immunol 1991;88:328–338CrossRefPubMed
2.
Zurück zum Zitat Sainte-Laudy J, Vallon C, Guérin JC. Analysis of membrane expression of the CD63 human basophil activation marker. Applications to allergologic diagnosis. Allerg Immunol (Leipz) 1994;26:211–214 Sainte-Laudy J, Vallon C, Guérin JC. Analysis of membrane expression of the CD63 human basophil activation marker. Applications to allergologic diagnosis. Allerg Immunol (Leipz) 1994;26:211–214
3.
Zurück zum Zitat Hoffmann HJ, Santos AF, Mayorga C, Nopp A, Eberlein B, Ferrer M, et al. The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease. Allergy 2015;70:1393–405CrossRefPubMed Hoffmann HJ, Santos AF, Mayorga C, Nopp A, Eberlein B, Ferrer M, et al. The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease. Allergy 2015;70:1393–405CrossRefPubMed
4.
Zurück zum Zitat Sturm EM, Kranzelbinder B, Heinemann A, Groselj-Strele A, Aberer W, Sturm GJ. CD203c-based basophil activation test in allergy diagnosis: characteristics and differences to CD63 upregulation. Cytometry B Clin Cytom 2010;78:308–318CrossRefPubMed Sturm EM, Kranzelbinder B, Heinemann A, Groselj-Strele A, Aberer W, Sturm GJ. CD203c-based basophil activation test in allergy diagnosis: characteristics and differences to CD63 upregulation. Cytometry B Clin Cytom 2010;78:308–318CrossRefPubMed
5.
Zurück zum Zitat Iqbal K, Bhargava K, Skov PS, Falkencrone S, Grattan CE. A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria. Clin Transl Allergy 2012;2:19CrossRefPubMedPubMedCentral Iqbal K, Bhargava K, Skov PS, Falkencrone S, Grattan CE. A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria. Clin Transl Allergy 2012;2:19CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Kvedariene V, Kamey S, Ryckwaert Y, Rongier M, Bousquet J, Demoly P, et al. Diagnosis of neuromuscular blocking agent hypersensitivity reactions using cytofluorimetric analysis of basophils. Allergy 2006;61:311–315CrossRefPubMed Kvedariene V, Kamey S, Ryckwaert Y, Rongier M, Bousquet J, Demoly P, et al. Diagnosis of neuromuscular blocking agent hypersensitivity reactions using cytofluorimetric analysis of basophils. Allergy 2006;61:311–315CrossRefPubMed
7.
Zurück zum Zitat Fernández TD, Torres MJ, Blanca-López N, Rodríguez-Bada JL, Gomez E, Canto G, et al. Negativization rates of IgE radioimmunoassay and basophil activation test in immediate reactions to penicillins. Allergy 2009;64:242–248CrossRefPubMed Fernández TD, Torres MJ, Blanca-López N, Rodríguez-Bada JL, Gomez E, Canto G, et al. Negativization rates of IgE radioimmunoassay and basophil activation test in immediate reactions to penicillins. Allergy 2009;64:242–248CrossRefPubMed
8.
Zurück zum Zitat Sousa N, Martínez-Aranguren R, Fernández-Benitez M, Ribeiro F, Sanz ML. Comparison of basophil activation test results in blood preserved in acid citrate dextrose and EDTA. J Investig Allergol Clin Immunol 2010;20:535–536PubMed Sousa N, Martínez-Aranguren R, Fernández-Benitez M, Ribeiro F, Sanz ML. Comparison of basophil activation test results in blood preserved in acid citrate dextrose and EDTA. J Investig Allergol Clin Immunol 2010;20:535–536PubMed
9.
Zurück zum Zitat Ando N, Nakamura Y, Ishimaru K, Ogawa H, Okumura K, Shimada S, et al. Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis. Allergy 2015;70:319–322CrossRefPubMed Ando N, Nakamura Y, Ishimaru K, Ogawa H, Okumura K, Shimada S, et al. Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis. Allergy 2015;70:319–322CrossRefPubMed
10.
Zurück zum Zitat Gentinetta T, Pecaric-Petkovic T, Wan D, Falcone FH, Dahinden CA, Pichler WJ, et al. Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria. J Allergy Clin Immunol 2011;128:1227–1234.CrossRefPubMed Gentinetta T, Pecaric-Petkovic T, Wan D, Falcone FH, Dahinden CA, Pichler WJ, et al. Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria. J Allergy Clin Immunol 2011;128:1227–1234.CrossRefPubMed
11.
Zurück zum Zitat Bühring H-J, Streble A, Valent P. The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis. Int Arch Allergy Immunol 2004;133:317–329CrossRefPubMed Bühring H-J, Streble A, Valent P. The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis. Int Arch Allergy Immunol 2004;133:317–329CrossRefPubMed
12.
Zurück zum Zitat De Weck AL, Sanz ML, Gamboa PM, Aberer W, Bienvenu J, Blanca M, et al. Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls. Int Arch Allergy Immunol 2008;146:177–189CrossRefPubMed De Weck AL, Sanz ML, Gamboa PM, Aberer W, Bienvenu J, Blanca M, et al. Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls. Int Arch Allergy Immunol 2008;146:177–189CrossRefPubMed
13.
Zurück zum Zitat Sturm GJ, Böhm E, Trummer M, Weiglhofer I, Heinemann A, Aberer W. The CD63 basophil activation test in Hymenoptera venom allergy: a prospective study. Allergy 2004;59:1110–1117CrossRefPubMed Sturm GJ, Böhm E, Trummer M, Weiglhofer I, Heinemann A, Aberer W. The CD63 basophil activation test in Hymenoptera venom allergy: a prospective study. Allergy 2004;59:1110–1117CrossRefPubMed
14.
Zurück zum Zitat Erdmann SM, Sachs B, Kwiecien R, Moll-Slodowy S, Sauer I, Merk HF. The basophil activation test in wasp venom allergy: sensitivity, specificity and monitoring specific immunotherapy. Allergy 2004;59:1102–1109CrossRefPubMed Erdmann SM, Sachs B, Kwiecien R, Moll-Slodowy S, Sauer I, Merk HF. The basophil activation test in wasp venom allergy: sensitivity, specificity and monitoring specific immunotherapy. Allergy 2004;59:1102–1109CrossRefPubMed
15.
Zurück zum Zitat Eberlein-König B, Varga R, Mempel M, Darsow U, Behrendt H, Ring J. Comparison of basophil activation tests using CD63 or CD203c expression in patients with insect venom allergy. Allergy 2006;61:1084–1085CrossRefPubMed Eberlein-König B, Varga R, Mempel M, Darsow U, Behrendt H, Ring J. Comparison of basophil activation tests using CD63 or CD203c expression in patients with insect venom allergy. Allergy 2006;61:1084–1085CrossRefPubMed
16.
Zurück zum Zitat Ocmant A, Peignois Y, Mulier S, Hanssens L, Michils A, Schandené L. Flow cytometry for basophil activation markers: the measurement of CD203c up-regulation is as reliable as CD63 expression in the diagnosis of cat allergy. J Immunol Methods 2007;320:40–48CrossRefPubMed Ocmant A, Peignois Y, Mulier S, Hanssens L, Michils A, Schandené L. Flow cytometry for basophil activation markers: the measurement of CD203c up-regulation is as reliable as CD63 expression in the diagnosis of cat allergy. J Immunol Methods 2007;320:40–48CrossRefPubMed
17.
Zurück zum Zitat Hausmann OV, Gentinetta T, Fux M, Ducrest S, Pichler WJ, Dahinden CA. Robust expression of CCR3 as a single basophil selection marker in flow cytometry. Allergy 2011;66:85–91CrossRefPubMed Hausmann OV, Gentinetta T, Fux M, Ducrest S, Pichler WJ, Dahinden CA. Robust expression of CCR3 as a single basophil selection marker in flow cytometry. Allergy 2011;66:85–91CrossRefPubMed
18.
Zurück zum Zitat Johansson SGO, Nopp A, van Hage M, Olofsson N, Lundahl J, Wehlin L, et al. Passive IgE-sensitization by blood transfusion. Allergy 2005;60:1192–1199.CrossRefPubMed Johansson SGO, Nopp A, van Hage M, Olofsson N, Lundahl J, Wehlin L, et al. Passive IgE-sensitization by blood transfusion. Allergy 2005;60:1192–1199.CrossRefPubMed
19.
Zurück zum Zitat Schmid JM, Würtzen PA, Dahl R, Hoffmann HJ. Early improvement in basophil sensitivity predicts symptom relief with grass pollen immunotherapy. J Allergy Clin Immunol 2014; 134: 741–744CrossRefPubMed Schmid JM, Würtzen PA, Dahl R, Hoffmann HJ. Early improvement in basophil sensitivity predicts symptom relief with grass pollen immunotherapy. J Allergy Clin Immunol 2014; 134: 741–744CrossRefPubMed
20.
Zurück zum Zitat Nopp A, Cardell LO, Johansson SGO, Oman H. CD-sens: a biological measure of immunological changes stimulated by ASIT. Allergy 2009;64:811–814CrossRefPubMed Nopp A, Cardell LO, Johansson SGO, Oman H. CD-sens: a biological measure of immunological changes stimulated by ASIT. Allergy 2009;64:811–814CrossRefPubMed
21.
Zurück zum Zitat Patil SU, Shreffler WG. Immunology in the Clinic Review Series; focus on allergies: basophils as biomarkers for assessing immune modulation. Clin Exp Immunol 2012;167:59–66CrossRefPubMedPubMedCentral Patil SU, Shreffler WG. Immunology in the Clinic Review Series; focus on allergies: basophils as biomarkers for assessing immune modulation. Clin Exp Immunol 2012;167:59–66CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Konstantinou GN, Asero R, Ferrer M, Knol EF, Maurer M, Raap U, et al. EAACI taskforce position paper: evidence for autoimmune urticaria and proposal for defining diagnostic criteria. Allergy 2013;68:27–36CrossRefPubMed Konstantinou GN, Asero R, Ferrer M, Knol EF, Maurer M, Raap U, et al. EAACI taskforce position paper: evidence for autoimmune urticaria and proposal for defining diagnostic criteria. Allergy 2013;68:27–36CrossRefPubMed
23.
Zurück zum Zitat Wedi B, Novacovic V, Koerner M, Kapp A. Chronic urticaria serum induces histamine release, leukotriene production, and basophil CD63 surface expression—inhibitory effects of anti-inflammatory drugs. J Allergy Clin Immunol 2000;105:552–560CrossRefPubMed Wedi B, Novacovic V, Koerner M, Kapp A. Chronic urticaria serum induces histamine release, leukotriene production, and basophil CD63 surface expression—inhibitory effects of anti-inflammatory drugs. J Allergy Clin Immunol 2000;105:552–560CrossRefPubMed
24.
Zurück zum Zitat Yasnowsky KM, Dreskin SC, Efaw B, Schoen D, Vedanthan PK, Alam R, et al. Chronic urticaria sera increase basophil CD203c expression. J Allergy Clin Immunol 2006;117:1430–1434CrossRefPubMed Yasnowsky KM, Dreskin SC, Efaw B, Schoen D, Vedanthan PK, Alam R, et al. Chronic urticaria sera increase basophil CD203c expression. J Allergy Clin Immunol 2006;117:1430–1434CrossRefPubMed
25.
Zurück zum Zitat Mayorga C, Sanz ML, Gamboa PM, García BE, Caballero MT, García JM, et al. In vitro diagnosis of immediate allergic reactions to drugs: an update. J Investig Allergol Clin Immunol 2010;20:103–109PubMed Mayorga C, Sanz ML, Gamboa PM, García BE, Caballero MT, García JM, et al. In vitro diagnosis of immediate allergic reactions to drugs: an update. J Investig Allergol Clin Immunol 2010;20:103–109PubMed
26.
Zurück zum Zitat Hausmann OV, Gentinetta T, Bridts CH, Ebo DG. The basophil activation test in immediate-type drug allergy. Immunol Allergy Clin North Am 2009;29:555–566CrossRefPubMed Hausmann OV, Gentinetta T, Bridts CH, Ebo DG. The basophil activation test in immediate-type drug allergy. Immunol Allergy Clin North Am 2009;29:555–566CrossRefPubMed
27.
Zurück zum Zitat Ocmant A, Mulier S, Hanssens L, Goldman M, Casimir G, Mascart F, et al. Basophil activation tests for the diagnosis of food allergy in children. Clin Exp Allergy J Br Soc Allergy Clin Immunol 2009;39:1234–1245CrossRef Ocmant A, Mulier S, Hanssens L, Goldman M, Casimir G, Mascart F, et al. Basophil activation tests for the diagnosis of food allergy in children. Clin Exp Allergy J Br Soc Allergy Clin Immunol 2009;39:1234–1245CrossRef
28.
Zurück zum Zitat Rubio A, Vivinus-Nébot M, Bourrier T, Saggio B, Albertini M, Bernard A. Benefit of the basophil activation test in deciding when to reintroduce cow’s milk in allergic children. Allergy 2011;66:92–100CrossRefPubMed Rubio A, Vivinus-Nébot M, Bourrier T, Saggio B, Albertini M, Bernard A. Benefit of the basophil activation test in deciding when to reintroduce cow’s milk in allergic children. Allergy 2011;66:92–100CrossRefPubMed
30.
Zurück zum Zitat Santos AF, Du Toit G, Douiri A, Radulovic S, Stephens A, Turcanu V, et al. Distinct parameters of the basophil activation test reflect the severity and threshold of allergic reactions to peanut. J Allergy Clin Immunol 2015;135:179–186CrossRefPubMedPubMedCentral Santos AF, Du Toit G, Douiri A, Radulovic S, Stephens A, Turcanu V, et al. Distinct parameters of the basophil activation test reflect the severity and threshold of allergic reactions to peanut. J Allergy Clin Immunol 2015;135:179–186CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Gernez Y, Tirouvanziam R, Yu G, Ghosn EEB, Reshamwala N, Nguyen T, et al. Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Int Arch Allergy Immunol 2011;154:318–327CrossRefPubMed Gernez Y, Tirouvanziam R, Yu G, Ghosn EEB, Reshamwala N, Nguyen T, et al. Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Int Arch Allergy Immunol 2011;154:318–327CrossRefPubMed
32.
Zurück zum Zitat Korošec P, Šilar M, Eržen R, Celesnik N, Bajrovic N, Zidarn M, et al. Clinical routine utility of basophil activation testing for diagnosis of hymenoptera-allergic patients with emphasis on individuals with negative venom-specific IgE antibodies. Int Arch Allergy Immunol 2013;161:363–368CrossRefPubMed Korošec P, Šilar M, Eržen R, Celesnik N, Bajrovic N, Zidarn M, et al. Clinical routine utility of basophil activation testing for diagnosis of hymenoptera-allergic patients with emphasis on individuals with negative venom-specific IgE antibodies. Int Arch Allergy Immunol 2013;161:363–368CrossRefPubMed
33.
Zurück zum Zitat Sturm GJ, Jin C, Kranzelbinder B, Hemmer W, Sturm EM, Griesbacher A, et al. Inconsistent results of diagnostic tools hamper the differentiation between bee and vespid venom allergy. PloS One 2011;6:e20842CrossRefPubMedPubMedCentral Sturm GJ, Jin C, Kranzelbinder B, Hemmer W, Sturm EM, Griesbacher A, et al. Inconsistent results of diagnostic tools hamper the differentiation between bee and vespid venom allergy. PloS One 2011;6:e20842CrossRefPubMedPubMedCentral
34.
Zurück zum Zitat Eberlein B, Krischan L, Darsow U, Ollert M, Ring J. Double positivity to bee and wasp venom: Improved diagnostic procedure by recombinant allergen-based IgE testing and basophil activation test including data about cross-reactive carbohydrate determinants. J Allergy Clin Immunol 2012; 130: 155–161CrossRefPubMed Eberlein B, Krischan L, Darsow U, Ollert M, Ring J. Double positivity to bee and wasp venom: Improved diagnostic procedure by recombinant allergen-based IgE testing and basophil activation test including data about cross-reactive carbohydrate determinants. J Allergy Clin Immunol 2012; 130: 155–161CrossRefPubMed
35.
Zurück zum Zitat Eržen R, Košnik M, Silar M, Korošec P. Basophil response and the induction of a tolerance in venom immunotherapy: a long-term sting challenge study. Allergy 2012;67:822–830CrossRefPubMed Eržen R, Košnik M, Silar M, Korošec P. Basophil response and the induction of a tolerance in venom immunotherapy: a long-term sting challenge study. Allergy 2012;67:822–830CrossRefPubMed
36.
Zurück zum Zitat Kosnik M, Silar M, Bajrovic N, Music E, Korosec P. High sensitivity of basophils predicts side-effects in venom immunotherapy. Allergy 2005;60:1401–1406CrossRefPubMed Kosnik M, Silar M, Bajrovic N, Music E, Korosec P. High sensitivity of basophils predicts side-effects in venom immunotherapy. Allergy 2005;60:1401–1406CrossRefPubMed
37.
Zurück zum Zitat Gómez E, Campo P, Rondón C, Barrionuevo E, Blanca-López N, Torres MJ et al. Role of the basophil activation test in the diagnosis of local allergic rhinitis. J Allergy Clin Immunol 2013;132:975–976CrossRefPubMed Gómez E, Campo P, Rondón C, Barrionuevo E, Blanca-López N, Torres MJ et al. Role of the basophil activation test in the diagnosis of local allergic rhinitis. J Allergy Clin Immunol 2013;132:975–976CrossRefPubMed
38.
Zurück zum Zitat Nopp A, Johansson SGO, Ankerst J, Bylin G, Cardell LO, Grönneberg R et al. Basophil allergen threshold sensitivity: a useful approach to anti-IgE treatment efficacy evaluation. Allergy 2006;61:298–302CrossRefPubMed Nopp A, Johansson SGO, Ankerst J, Bylin G, Cardell LO, Grönneberg R et al. Basophil allergen threshold sensitivity: a useful approach to anti-IgE treatment efficacy evaluation. Allergy 2006;61:298–302CrossRefPubMed
39.
Zurück zum Zitat Dahlén B, Nopp A, Johansson SGO, Eduards M, Skedinger M, Adédoyin J. Basophil allergen threshold sensitivity, CD-sens, is a measure of allergen sensitivity in asthma. Clin Exp Allergy 2011;41:1091–1097CrossRefPubMed Dahlén B, Nopp A, Johansson SGO, Eduards M, Skedinger M, Adédoyin J. Basophil allergen threshold sensitivity, CD-sens, is a measure of allergen sensitivity in asthma. Clin Exp Allergy 2011;41:1091–1097CrossRefPubMed
40.
Zurück zum Zitat Johansson SGO, Nopp A, Oman H, Ankerst J, Cardell LO, Grönneberg R et al. The size of the disease relevant IgE antibody fraction in relation to’ total-IgE’ predicts the efficacy of anti-IgE (Xolair) treatment. Allergy 2009;64:1472–1477CrossRefPubMed Johansson SGO, Nopp A, Oman H, Ankerst J, Cardell LO, Grönneberg R et al. The size of the disease relevant IgE antibody fraction in relation to’ total-IgE’ predicts the efficacy of anti-IgE (Xolair) treatment. Allergy 2009;64:1472–1477CrossRefPubMed
Metadaten
Titel
Basophil activation testing in diagnosis and monitoring of allergic disease – an overview
verfasst von
Prof. Dr. Bernadette Eberlein
Alexandra F. Santos
Cristobalina Mayorga
Anna Nopp
Marta Ferrer
Paul Rouzaire
Didier Ebo
Vito Sabato
Maria L. Sanz
Tatjana Pecaric-Petkovic
Sarita U. Patil
Oliver V. Hausmann
Wayne G. Shreffler
Peter Korosec
Edward F. Knol
Hans Jürgen Hoffmann
Publikationsdatum
27.06.2016
Verlag
Springer Medizin
Erschienen in
Allergo Journal / Ausgabe 4/2016
Print ISSN: 0941-8849
Elektronische ISSN: 2195-6405
DOI
https://doi.org/10.1007/s15007-016-1105-y

Weitere Artikel der Ausgabe 4/2016

Allergo Journal 4/2016 Zur Ausgabe

AeDA/DGAKI informieren

Diagnostik gegen den Trend

AeDA/DGAKI informieren

Entdecken Sie die Hauptstadt!

AeDA/DGAKI informieren

Ausgewählte Programmhighlights

Neu im Fachgebiet HNO

Lungenkrebsscreening – so häufig sind Nebenbefunde im Halsbereich

Beim Low-Dose-CT-Screening von starken Raucherinnen und Rauchern ist mit einer hohen Rate von Zufallsbefunden zu rechnen: In einer US-amerikanischen Studie waren bei einem von 19 Gescreenten Auffälligkeiten im Halsbereich zu erkennen, fast alle betrafen die Schilddrüse.

Frühe orale Toleranz statt Sensibilisierung über die Haut

Personen mit atopischer Dermatitis haben begleitend häufig Nahrungsmittelallergien. Die geschädigte Hautbarriere spielt eine entscheidende Rolle bei der Sensibilisierung und erschwert die orale Toleranzentwicklung. Umso wichtiger ist die Regeneration der Hautbarriere.

Schutz der Schleimhautbarriere bei chronischer Rhinosinusitis

Die Gewebsumgestaltung der oberen Atemwege („airway remodeling“) bei allergischem Asthma und chronischer Rhinosinusitis mit nasalen Polypen (CRSwNP) ist nach der neuen Nomenklatur allergischer Erkrankungen der EAACI ein eigenständiger gewebespezifischer Mechanismus.

Immunologische Endotypen beim CRSwNP – neue Nomenklatur

„Die chronische Rhinosinusitis mit Nasenpolypen (CRSwNP) zeigt immunologisch ein sehr heterogenes Bild“, wie Prof. Moritz Gröger, LMU-Klinikum München, beim Deutschen Allergiekongress 2024 dargestellt hat. Der immunologische Endotyp sei hierbei mit dem klinischen Phänotyp assoziiert.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.