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Archives of Virology

Erschienen in:

13.06.2018 | Brief Report

BCP/PC mutation prevalence and their association with HBV replication in HIV/HBV co-infected patients

verfasst von: Dongdong Li, Qixia Chen, Chuanmin Tao

Erschienen in: Archives of Virology | Ausgabe 10/2018

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Abstract

The high prevalence (14.3%) of HIV/HBV co-infections reported in west China makes it necessary to screen concurrent HBV infection in HIV carriers. HBV B genotype was shown to be dominant in 54 cases of HIV/HBV co-infection, accounting for 81.48% of the total. The total drug resistance rate observed was 3.70%. A1762T, G1764A and G1896A mutations were common mutations identified in the BCP/PC region. However, the prevalence of the G1896A mutation was significantly high among the HBeAg negative HIV/HBV co-infected patients, and may be associated with high HBV replication. Mutations in the PC region are related to the loss in synthesis of HBeAg and may accelerate HBV replication in HIV positive patients.

Baseke J, Musenero M, Mayanja-Kizza H (2015) Prevalence of hepatitis B and C and relationship to liver damage in HIV infected patients attending Joint Clinical Research Centre Clinic (JCRC), Kampala, Uganda. Afr Health Sci 15:322–327CrossRefPubMedPubMedCentral

Brandao NA, Pfrimer IA, Martelli CM, Turchi MD (2015) Prevalence of hepatitis B and C infection and associated factors in people living with HIV in Midwestern Brazil. Braz J Infect Dis 19:426–430CrossRefPubMed

Cassino L, Laufer N, Salomon H, Campos R, Quarleri J (2009) Hepatitis B precore/core promoter mutations in isolates from HBV-monoinfected and HBV-HIV coinfected patients: a 3-yr prospective study. J Clin Virol 46:354–359CrossRefPubMed

Castelain S, Descamps V, Brochot E, Helle F, Duverlie G, Nguyen-Khac E, Francois C (2017) High association of T1858-G1896 precore mutations with impaired base pairing and high hepatitis B virus DNA levels in HBeAg-negative chronically infected patients. Adv Virol 162:1913–1920

Huy BV, Vernavong K, Kinh NV (2014) HBV and HCV coinfection among HIV/AIDS patients in the National Hospital of Tropical Diseases, Vietnam. AIDS Res Treat 2014:581021PubMedPubMedCentral

Kamijo N, Matsumoto A, Umemura T, Shibata S, Ichikawa Y, Kimura T, Komatsu M, Tanaka E (2015) Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion. World J Gastroenterol 21:541–548CrossRefPubMedPubMedCentral

Kim H, Lee SA, Do SY, Kim BJ (2016) Precore/core region mutations of hepatitis B virus related to clinical severity. World J Gastroenterol 22:4287–4296CrossRefPubMedPubMedCentral

Koumbi L, Pollicino T, Raimondo G, Stampoulis D, Khakoo S, Karayiannis P (2016) Hepatitis B virus basal core promoter mutations show lower replication fitness associated with cccDNA acetylation status. Virus Res 220:150–160CrossRefPubMed

Li KW, Kramvis A, Liang S, He X, Chen QY, Wang C, Yang QL, Hu LP, Jia HH, Fang ZL (2017) Higher prevalence of cancer related mutations 1762T/1764A and PreS deletions in hepatitis B virus (HBV) isolated from HBV/HIV co-infected compared to HBV-mono-infected Chinese adults. Virus Res 227:88–95CrossRefPubMed

10.

Liao Y, Hu X, Chen J, Cai B, Tang J, Ying B, Wang H, Wang L (2012) Precore mutation of hepatitis B virus may contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis. PLoS One 7:e38394CrossRefPubMedPubMedCentral

11.

Luo Q, Zhong Y, Yang Y, Xiong Q, Hu Z, Lu W, Huang P, Zhang N (2012) Clinical characteristics and chronicity of acute hepatitis B induced by lamivudine-resistant strains. J Med Virol 84:1558–1561CrossRefPubMed

12.

Nian X, Xu Z, Liu Y, Chen J, Li X, Xu D (2016) Association between hepatitis B virus basal core promoter/precore region mutations and the risk of hepatitis B-related acute-on-chronic liver failure in the Chinese population: an updated meta-analysis. Hep Int 10:606–615CrossRef

13.

Nikolopoulos GK, Paraskevis D, Psichogiou M, Hatzakis A (2016) HBV-DNA levels predict overall mortality in HIV/HBV coinfected individuals. J Med Virol 88:466–473CrossRefPubMed

14.

Noubiap JJ, Aka PV, Nanfack AJ, Agyingi LA, Ngai JN, Nyambi PN (2015) Hepatitis B and C co-infections in some HIV-positive populations in Cameroon, West Central Africa: analysis of samples collected over more than a decade. PLoS One 10:e0137375CrossRefPubMedPubMedCentral

15.

Oliveira MP, Lemes PS, Matos MA, Del-Rios NH, Carneiro MA, Silva AM, Lopes CL, Teles SA, Aires RS, Lago BV, Araujo NM, Martins RM (2016) Overt and occult hepatitis B virus infection among treatment-naive HIV-infected patients in Brazil. J Med Virol 88:1222–1229CrossRefPubMed

16.

Otto-Knapp R, Cortes CP, Saavedra F, Wolff M, Weitzel T (2013) Hepatitis B prevalence and influence on HIV treatment outcome and mortality in the Chilean AIDS Cohort. Int J Infect Dis 17:e919–924CrossRefPubMed

17.

Puglia M, Stasi C, Da Fre M, Voller F (2016) Prevalence and characteristics of HIV/HBV and HIV/HCV coinfections in Tuscany. Braz J Infect Dis 20:330–334CrossRefPubMed

18.

Rajbhandari R, Jun T, Khalili H, Chung RT, Ananthakrishnan AN (2016) HBV/HIV coinfection is associated with poorer outcomes in hospitalized patients with HBV or HIV. J Viral Hepatitis 23:820–829CrossRef

19.

Ramirez-Mena A, Glass TR, Winter A, Kimera N, Ntamatungiro A, Hatz C, Tanner M, Battegay M, Furrer H, Wandeler G, Letang E (2016) Prevalence and outcomes of hepatitis B coinfection and associated liver disease among antiretroviral therapy-naive individuals in a rural Tanzanian human immunodeficiency virus cohort. Open Forum Infect Dis 3:ofw162CrossRefPubMedPubMedCentral

20.

Saha D, Pal A, Biswas A, Panigrahi R, Sarkar N, Das D, Sarkar J, Guha SK, Saha B, Chakrabarti S, Chakravarty R (2014) Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India. PLoS One 9:e90432CrossRefPubMedPubMedCentral

21.

Sayed SK, Kobeisy MA (2012) The relationship between core promoter mutation of hepatitis B virus, viral load and hepatitis B e antigen status in chronic hepatitis B patients. Cell Immunol 276:35–41CrossRefPubMed

22.

Sharma A, Halim J, Jaggi T, Mishra B, Thakur A, Dogra V, Loomba PS (2016) Time trends of seroepidemiology of hepatitis C virus and hepatitis B virus coinfection in human immunodeficiency virus-infected patients in a Super Specialty Hospital in New Delhi, India: 2012–2014. Indian J Sex Transm Dis 37:33–37CrossRef

23.

Soriano V, Poveda E, Vispo E, Barreiro P (2013) Hepatitis B in HIV-infected patients. Clin Liver Dis 17:489–501CrossRefPubMed

24.

Wang XL, Ren JP, Wang XQ, Wang XH, Yang SF, Xiong Y (2016) Mutations in pre-core and basic core promoter regions of hepatitis B virus in chronic hepatitis B patients. World J Gastroenterol 22:3268–3274CrossRefPubMedPubMedCentral

25.

Wang Z, Huang Y, Wen S, Zhou B, Hou J (2007) Hepatitis B virus genotypes and subgenotypes in China. Hepatol Res 37:S36–41CrossRefPubMed

26.

WHO (2009) Hepatitis B vaccines. Relev Epidemiol Hebd 84:405–419

27.

Xie J, Han Y, Qiu Z, Li Y, Li Y, Song X, Wang H, Thio CL, Li T (2016) Prevalence of hepatitis B and C viruses in HIV-positive patients in China: a cross-sectional study. J Int AIDS Soc 19:20659CrossRefPubMedPubMedCentral

28.

Yan LB, Zhu X, Bai L, Tang XQ, Du LY, Chen EQ, Liang LB, Tang H (2016) Mutations in basal core promoter is associated with significant fibrosis in both HBeAg positive and negative treatment-naive chronic hepatitis B. Clin Res Hepatol Gastroenterol 41:296CrossRefPubMed

29.

Yang G, Han M, Chen F, Xu Y, Chen E, Wang X, Liu Y, Sun J, Hou J, Ning Q, Wang Z (2014) Hepatitis B virus genotype B and mutations in basal core promoter and pre-core/core genes associated with acute-on-chronic liver failure: a multicenter cross-sectional study in China. Hep Intl 8:508–516CrossRef

30.

Yang T, Chen Q, Li D, Wang T, Gou Y, Wei B, Tao C (2018) High prevalence of syphilis, HBV, and HCV co-infection, and low rate of effective vaccination against hepatitis B in HIV-infected patients in West China hospital. J Med Virol 90:101–108CrossRefPubMed

31.

Yang Z, Zhuang L, Lu Y, Xu Q, Tang B, Chen X (2016) Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma: a meta-analysis. Oncotarget 7:12525–12536PubMedPubMedCentral

32.

Zhang F, Zhu H, Wu Y, Dou Z, Zhang Y, Kleinman N, Bulterys M, Wu Z, Ma Y, Zhao D, Liu X, Fang H, Liu J, Cai WP, Shang H (2014) HIV, hepatitis B virus, and hepatitis C virus co-infection in patients in the China National Free Antiretroviral Treatment Program, 2010–12: a retrospective observational cohort study. Lancet Infect Dis 14:1065–1072CrossRefPubMedPubMedCentral

33.

Zhang Q, Liao Y, Cai B, Li Y, Li L, Zhang J, An Y, Wang L (2015) Incidence of natural resistance mutations in naive chronic hepatitis B patients: a systematic review and meta-analysis. J Gastroenterol Hepatol 30:252–261CrossRefPubMed

34.

Zhang Q, Liao Y, Chen J, Cai B, Su Z, Ying B, Lu X, Tao C, Wang L (2015) Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China. Sci Rep 5:17413CrossRefPubMedPubMedCentral

Titel: BCP/PC mutation prevalence and their association with HBV replication in HIV/HBV co-infected patients
verfasst von: Dongdong Li
Qixia Chen
Chuanmin Tao
Publikationsdatum: 13.06.2018
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 10/2018
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-018-3900-0

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