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01.08.2010 | Review | Ausgabe 4/2010

Critical Care 4/2010

Bench-to-bedside review: Targeting antioxidants to mitochondria in sepsis

Zeitschrift:
Critical Care > Ausgabe 4/2010
Autor:
Helen F Galley
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​cc9098) contains supplementary material, which is available to authorized users.

Competing interests

HFG has received gifts of MitoQ and MitoVitE from Antipodean Pharmaceuticals, Inc. (Auckland, New Zealand) for use in research studies.

Abstract

Development of organ dysfunction associated with sepsis is now accepted to be due at least in part to oxidative damage to mitochondria. Under normal circumstances, complex interacting antioxidant defense systems control oxidative stress within mitochondria. However, no studies have yet provided conclusive evidence of the beneficial effect of antioxidant supplementation in patients with sepsis. This may be because the antioxidants are not accumulating in the mitochondria, where they are most needed. Antioxidants can be targeted selectively to mitochondria by several means. This review describes the in vitro studies and animal models of several diseases involving oxidative stress, including sepsis, in which antioxidants targeted at mitochondria have shown promise, and the future implications for such approaches in patients.

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