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Inflammopharmacology

Erschienen in:

01.06.2023 | Review

Beneficial effects of flavonoids on cardiovascular diseases by influencing NLRP3 inflammasome

verfasst von: Hai-yan Fang, Xiao-ni Zhao, Meng Zhang, Yao-yao Ma, Jin-ling Huang, Peng Zhou

Erschienen in: Inflammopharmacology | Ausgabe 4/2023

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Abstract

Cardiovascular diseases (CVDs) are a leading cause of global mortality and have a high incidence rate worldwide. The function of inflammasomes in CVDs has received a lot of attention recently, and the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome may be a new target for the prevention and treatment of CVDs. Flavonoids, which are found in food and plant extracts, inhibited inflammation in CVDs by regulating the NLRP3 inflammasome. CB-Dock was used to investigate whether 34 flavonoids from natural products acted on NLRP3 inflammasome. In brief, the PDB format of NLRP3 was selected as a protein file, and 34 flavonoids in SDF format were selected as the ligand file, and then input to CB-Dock for molecular docking. The docking results showed that epigallocatechin-3-gallate (EGCG), amentoflavone, baicalin, scutellarin, vitexin, silibinin, and puerarin had good binding affinities to NLRP3, which could be used as NLRP3 inhibitors, and aid in the discovery of lead compounds for the design and development of CVDs.

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Titel: Beneficial effects of flavonoids on cardiovascular diseases by influencing NLRP3 inflammasome
verfasst von: Hai-yan Fang
Xiao-ni Zhao
Meng Zhang
Yao-yao Ma
Jin-ling Huang
Peng Zhou
Publikationsdatum: 01.06.2023
Verlag: Springer International Publishing
Erschienen in: Inflammopharmacology / Ausgabe 4/2023
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-023-01249-2

Springer Medizin

Abstract

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