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Erschienen in: European Journal of Nutrition 8/2013

01.12.2013 | Original Contribution

Beneficial effects of omega-3 fatty acids on the consequences of a fructose diet are not mediated by PPAR delta or PGC1 alpha

verfasst von: Julie Karsenty, Jean-François Landrier, Delphine Rousseau-Ralliard, Vanessa Robbez-Masson, Alain Margotat, Paule Deprez, Paulette Lechêne, Alain Grynberg, Denis Lairon, Richard Planells, Marguerite Gastaldi

Erschienen in: European Journal of Nutrition | Ausgabe 8/2013

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Abstract

Purpose

To study, in high-fructose-fed rats, the effect of a dietary enrichment in omega-3 polyunsaturated fatty acids (n-3 PUFA) on the expression of genes involved in lipid metabolism and cardiovascular function.

Methods

Twenty-eight male “Wistar Han” rats received for 8 weeks, either a standard chow food or an isocaloric 67 % fructose diet enriched or not in alpha-linolenic acid (ALA) or in docosahexaenoic (DHA) and eicosapentaenoic acids (EPA) mix (DHA/EPA). After sacrifice, blood was withdrawn for biochemical analyses; heart, periepididymal adipose tissue and liver were collected and analyzed for the expression of 22 genes by real-time PCR.

Results

Fructose intake resulted in an increase in liver weight and triglyceride content, plasma triglyceride and cholesterol concentrations, although no difference in glucose and insulin. In the liver, lipogenesis was promoted as illustrated by an increase in stearoyl-CoA desaturase and fatty acid synthase (Fasn) together with a decrease in PPAR gamma, delta and PPAR gamma coactivator 1 alpha (PGC1 alpha) expression. In the heart, Fasn and PPAR delta expression were increased. The addition of ALA or DHA/EPA into the diet resulted in a protection against fructose effects except for the decreased expression of PPARs in the liver that was not counterbalanced by n-3 PUFA suggesting that n-3 PUFA and fructose act independently on the expression of PPARs and PGC1 alpha.

Conclusions

In liver, but not in heart, the fructose-enriched diet induces an early tissue-specific reduction in PPAR gamma and delta expression, which is insensitive to n-3 PUFA intake and dissociated from lipogenesis.
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Metadaten
Titel
Beneficial effects of omega-3 fatty acids on the consequences of a fructose diet are not mediated by PPAR delta or PGC1 alpha
verfasst von
Julie Karsenty
Jean-François Landrier
Delphine Rousseau-Ralliard
Vanessa Robbez-Masson
Alain Margotat
Paule Deprez
Paulette Lechêne
Alain Grynberg
Denis Lairon
Richard Planells
Marguerite Gastaldi
Publikationsdatum
01.12.2013
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nutrition / Ausgabe 8/2013
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-012-0488-0

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