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Cardiovascular Toxicology
Erschienen in: Cardiovascular Toxicology 3/2018

27.10.2017

Beneficial Role of Some Natural Products to Attenuate the Diabetic Cardiomyopathy Through Nrf2 Pathway in Cell Culture and Animal Models

verfasst von: V. V. Sathibabu Uddandrao, Parim Brahmanaidu, P. R. Nivedha, S. Vadivukkarasi, Ganapathy Saravanan

Erschienen in: Cardiovascular Toxicology | Ausgabe 3/2018

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Abstract

Diabetic cardiomyopathy, as one of the main cardiac complications in diabetic patients, is identified to connect with oxidative stress that is due to interruption in balance between reactive oxygen species or/and reactive nitrogen species generation and their clearance by antioxidant protection systems. Transcription factor the nuclear factor erythroid 2-related factor 2 (Nrf2) plays a significant role in maintaining the oxidative homeostasis by regulating multiple downstream antioxidants. The Nrf2 plays a significant role in ARE-mediated basal and inducible expression of more than 200 genes that can be grouped into numerous categories as well as antioxidant genes and phase II detoxifying enzymes. On the other hand, activation of Nrf2 by natural and synthetic therapeutics or antioxidants has been revealed effective for the prevention and treatment of toxicities and diseases connected with oxidative stress. Hence, recently focus has been shifted toward plants and plant-based medicines in curing such chronic diseases, as they are supposed to be less toxic. In this review, we focused on the role of some natural products on diabetic cardiomyopathy through Nrf2 pathway.
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Metadaten
Titel
Beneficial Role of Some Natural Products to Attenuate the Diabetic Cardiomyopathy Through Nrf2 Pathway in Cell Culture and Animal Models
verfasst von
V. V. Sathibabu Uddandrao
Parim Brahmanaidu
P. R. Nivedha
S. Vadivukkarasi
Ganapathy Saravanan
Publikationsdatum
27.10.2017
Verlag
Springer US
Erschienen in
Cardiovascular Toxicology / Ausgabe 3/2018
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI
https://doi.org/10.1007/s12012-017-9430-2

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