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Erschienen in: Cancer Immunology, Immunotherapy 2/2015

01.02.2015 | Original Article

Benefit of adjuvant interferon alfa-2b (IFN-α) therapy in melanoma patients with high serum MMP-8 levels

verfasst von: Pia Vihinen, Taina Tervahartiala, Timo Sorsa, Johan Hansson, Lars Bastholt, Steinar Aamdal, Ulrika Stierner, Seppo Pyrhönen, Kari Syrjänen, Johan Lundin, Micaela Hernberg

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 2/2015

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Abstract

Matrix metalloproteinases (MMPs) are important enzymes in tissue turnover and various inflammatory processes. In this study, it was evaluated whether serum MMP-8 can predict the response to adjuvant interferon alfa-2b (IFN-α) therapy in patients with operated high-risk cutaneous melanoma. Pre-treatment sera from 460 patients with stage IIB–IIIC melanoma were analyzed for MMP-8. The patients were randomized after surgery to adjuvant IFN-α for 12 or 24 months (n = 313) or observation only (n = 147). The median serum MMP-8 level was used to classify the patients into a low MMP-8 (n = 232) and a high MMP-8 (n = 228) group. In the high MMP-8 subgroup, IFN-α therapy significantly improved relapse-free survival (RFS). RFS was 36.8 months in patients with high MMP-8 levels receiving IFN-α therapy, whereas RFS for those with high MMP-8 levels with observation only was 10.6 months (P = 0.027). Median overall survival for patients with high MMP-8 and observation only was 36.7 versus 71.7 months in those receiving IFN-α (P = 0.13). In a multivariate model, IFN-α therapy was a significant predictor of favorable RFS (HR 0.74; 95 % CI 0.55–0.99; P = 0.048), after adjustment for pre-treatment MMP-8 (HR 1.17; 95 % CI 0.88–1.55; P = 0.28), gender (HR 1.16; 95 % CI 0.86–1.56; P = 0.32), age (HR 1.00; 95 % CI 1.00–1.02; P = 0.12), ulceration (HR 1.09; 95 % CI 0.81–1.46; P = 0.58), and the presence of node metastases (HR 1.36; 95 % CI 1.17–1.58; P < 0.0001). In conclusion, patients with high serum MMP-8 levels may benefit from adjuvant IFN-α therapy, but this observation should be further investigated.
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Metadaten
Titel
Benefit of adjuvant interferon alfa-2b (IFN-α) therapy in melanoma patients with high serum MMP-8 levels
verfasst von
Pia Vihinen
Taina Tervahartiala
Timo Sorsa
Johan Hansson
Lars Bastholt
Steinar Aamdal
Ulrika Stierner
Seppo Pyrhönen
Kari Syrjänen
Johan Lundin
Micaela Hernberg
Publikationsdatum
01.02.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Cancer Immunology, Immunotherapy / Ausgabe 2/2015
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-014-1620-1

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