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Osteoporosis International

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01.07.2010 | Review

Benefit–risk assessment of vitamin D supplementation

verfasst von: H. A. Bischoff-Ferrari, A. Shao, B. Dawson-Hughes, J. Hathcock, E. Giovannucci, W. C. Willett

Erschienen in: Osteoporosis International | Ausgabe 7/2010

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Abstract

Summary

Current intake recommendations of 200 to 600 IU vitamin D per day may be insufficient for important disease outcomes reduced by vitamin D.

Introduction

This study assessed the benefit of higher-dose and higher achieved 25-hydroxyvitamin D levels [25(OH)D] versus any associated risk.

Methods and results

Based on double-blind randomized control trials (RCTs), eight for falls (n = 2426) and 12 for non-vertebral fractures (n = 42,279), there was a significant dose–response relationship between higher-dose and higher achieved 25(OH)D and greater fall and fracture prevention. Optimal benefits were observed at the highest dose tested to date for 700 to 1000 IU vitamin D per day or mean 25(OH)D between 75 and 110 nmol/l (30–44 ng/ml). Prospective cohort data on cardiovascular health and colorectal cancer prevention suggested increased benefits with the highest categories of 25(OH)D evaluated (median between 75 and 110 nmol/l). In 25 RCTs, mean serum calcium levels were not related to oral vitamin D up to 100,000 IU per day or achieved 25(OH)D up to 643 nmol/l. Mean levels of 75 to 110 nmol/l were reached in most RCTs with 1,800 to 4,000 IU vitamin D per day without risk.

Conclusion

Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.

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Titel: Benefit–risk assessment of vitamin D supplementation
verfasst von: H. A. Bischoff-Ferrari
A. Shao
B. Dawson-Hughes
J. Hathcock
E. Giovannucci
W. C. Willett
Publikationsdatum: 01.07.2010
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe 7/2010
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-1119-3

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Benefit–risk assessment of vitamin D supplementation

Abstract

Summary

Introduction

Methods and results

Conclusion

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