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07.01.2016 | Original Article | Ausgabe 6/2016

European Journal of Nuclear Medicine and Molecular Imaging 6/2016

Beta-amyloid deposition and cognitive function in patients with major depressive disorder with different subtypes of mild cognitive impairment: 18F-florbetapir (AV-45/Amyvid) PET study

Zeitschrift:
European Journal of Nuclear Medicine and Molecular Imaging > Ausgabe 6/2016
Autoren:
Kuan-Yi Wu, Chia-Yih Liu, Cheng-Sheng Chen, Chia-Hsiang Chen, Ing-Tsung Hsiao, Chia-Ju Hsieh, Chin-Pang Lee, Tzu-Chen Yen, Kun-Ju Lin
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00259-015-3291-3) contains supplementary material, which is available to authorized users.

Abstract

Purpose

The objective of this study was to evaluate the amyloid burden, as assessed by 18F-florbetapir (AV-45/Amyvid) positron emission tomography PET, in patients with major depressive disorder (MDD) with different subtypes of mild cognitive impairment (MCI) and the relationship between amyloid burden and cognition in MDD patients.

Methods

The study included 55 MDD patients without dementia and 21 healthy control subjects (HCs) who were assessed using a comprehensive cognitive test battery and 18F-florbetapir PET imaging. The standardized uptake value ratios (SUVR) in eight cortical regions using the whole cerebellum as reference region were determined and voxel-wise comparisons between the HC and MDD groups were performed. Vascular risk factors, serum homocysteine level and the apolipoprotein E (ApoE) genotype were also determined.

Results

Among the 55 MDD patients, 22 (40.0 %) had MCI, 12 (21.8 %) non-amnestic MCI (naMCI) and 10 (18.2 %) amnestic MCI (aMCI). The MDD patients with aMCI had the highest relative 18F-florbetapir uptake in all cortical regions, and a significant difference in relative 18F-florbetapir uptake was found in the parietal region as compared with that in naMCI subjects (P < 0.05) and HCs (P < 0.01). Voxel-wise analyses revealed significantly increased relative 18F-florbetapir uptake in the MDD patients with aMCI and naMCI in the frontal, parietal, temporal and occipital areas (P < 0.005). The global cortical SUVR was significantly negatively correlated with MMSE score (r = −0.342, P = 0.010) and memory function (r = −0.328, P = 0.015). The negative correlation between the global SUVR and memory in the MDD patients remained significant in multiple regression analyses that included age, educational level, ApoE genotype, and depression severity (β = −3.607, t = −2.874, P = 0.006).

Conclusion

We found preliminary evidence of brain beta-amyloid deposition in MDD patients with different subtypes of MCI. Our findings in MDD patients support the hypothesis that a higher amyloid burden is associated with a poorer memory performance. We also observed a high prevalence of MCI among elderly depressed patients, and depressed patients with MCI exhibited heterogeneously elevated 18F-florbetapir retention as compared with depressed patients without MCI. The higher amyloid burden in the aMCI patients suggests that these patients may also be more likely to develop Alzheimer’s disease than other patients diagnosed with major depression.

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ESM 1 (PDF 5 kb)
259_2015_3291_MOESM1_ESM.pdf
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