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Erschienen in: Cancer and Metastasis Reviews 3/2019

28.10.2019

Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment

verfasst von: Afshin Moradi, Srilakshmi Srinivasan, Judith Clements, Jyotsna Batra

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 3/2019

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Abstract

The prostate-specific antigen (PSA) blood test is the accepted biomarker of tumor recurrence. PSA levels in serum correlate with disease progression, though its diagnostic accuracy is questionable. As a result, significant progress has been made in developing modified PSA tests such as PSA velocity, PSA density, 4Kscore, PSA glycoprofiling, Prostate Health Index, and the STHLM3 test. PSA, a serine protease, is secreted from the epithelial cells of the prostate. PSA has been suggested as a molecular target for prostate cancer therapy due to the fact that it is not only active in prostate tissue but also has a pivotal role on prostate cancer signaling pathways including proliferation, invasion, metastasis, angiogenesis, apoptosis, immune response, and tumor microenvironment regulation. Here, we summarize the current standing of PSA in prostate cancer progression as well as its utility in prostate cancer therapeutic approaches with an emphasis on the role of PSA in the tumor microenvironment.
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Metadaten
Titel
Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment
verfasst von
Afshin Moradi
Srilakshmi Srinivasan
Judith Clements
Jyotsna Batra
Publikationsdatum
28.10.2019
Verlag
Springer US
Erschienen in
Cancer and Metastasis Reviews / Ausgabe 3/2019
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-019-09815-3

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