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The online version of this article (doi:10.1186/1749-8546-9-19) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
SCWS, YBZ, ZJZ, and YT designed and conceived the study. SCWS, RNSW, WKL, TBN and PCS, select and organize the contents of manuscript. KLW, LZ, HPC, and JL wrote the manuscript. TBN, PCLK and YML provided the constructive comments and re-wrote parts of manuscript. All authors read and approved the final version of the manuscript.
Some protein pharmaceuticals from Chinese medicine have been developed to treat cardiovascular diseases, genetic diseases, and cancer. Bioactive proteins with various pharmacological properties have been successfully isolated from animals such as Hirudo medicinalis (medicinal leech), Eisenia fetida (earthworm), and Mesobuthus martensii (Chinese scorpion), and from herbal medicines derived from species such as Cordyceps militaris, Ganoderma, Momordica cochinchinensis, Viscum album, Poria cocos, Senna obtusifolia, Panax notoginseng, Smilax glabra, Ginkgo biloba, Dioscorea batatas, and Trichosanthes kirilowii. This article reviews the isolation methods, molecular characteristics, bioactivities, pharmacological properties, and potential uses of bioactive proteins originating from these Chinese medicines.