Background
Materials and methods
Microarray data information
Data processing and DEG identification
DEGs | Genes symbol |
---|---|
Upregulated (10) | FN1, CXCL10, LAMB1, LHX2, CHI3L1, ZIC2, TNFAIP6, GAD1, NUF2, PARPBP |
Downregulated (142) | SCNN1A, CCDC173, AGR2, GSTA3, FAM3D, PRSS23, UBXN10, SLC2A10, LRRC10B NME5, LOC100653057, CFAP53, C9orf116, TPPP, LOC101930373, DNAH9, ADGB, CCDC181, ZMYND10, OSCP1, SPATA17, KCNRG, CDHR3, CCDC96, CFAP70, ABCA13, MFSD4A, TMEM45B, IQCD, TMC5, NQO1, LRRC34, DUOX1, VWA3B, NEK5, CXCL17, CAPS2, IQCA1, RSPH9, CAPS, TTC9, SLC44A4, MS4A8, AKAP14, ADH1C, RBM24, ARMC4, ADGRF1, AK7, MDH1B, TMEM231, C11orf97, ARMC3, CFAP45, CATSPERD, C2orf40, SORBS2, PACRG, DNAI2, CHL1, WFDC2, SPAG6, MORN5, CCDC190, PIFO, CLU, TEKT1, MUC5AC, DNAJA4, DHRS9, CLDN23, CDH26, C4orf22, CFAP126, TTC29, ST6GALNAC1, CLDN10, MUC1, FAM216B, TMEM190, LRRC46, MIR675, RSPH4A, LOC101928817, AKR1C3, LOC101927416, F3, SERPINB3, ZBBX, SLC6A14, TTC25, ROPN1L, DNALI1, BPIFB1, TMEM232, CASC1, RRAD, SCIN, SAXO2, CFAP43, TSPAN1, SLPI, ALDH3A1, C11orf70, CAPSL, DNAH12, CHST9, CLIC6, TPPP3, KCNE1, CCDC113, CYP4B1, MUC16, CEACAM5, MSMB, SCGB1A1, DYNLRB2, ERICH3, UPK1B, MUC4, LCN2, C9orf135, CFAP52, C7orf57, CEACAM6, S100P, LOC101927057, EFHB, OMG, RSPH1, FAM81B, AGR3, PIGR, C9orf24, LTF, C19orf33, GSTA1, AQP3, CDC20B, C20orf85, SNTN, CES1 |
Gene functional and pathway enrichment analysis of DEGs
PPI network construction and identification of hub genes
Transcriptional factor regulatory network of hub genes
Results
Identification of the DEGs of NPC
Functional and pathway enrichment analysis of DEGs
PPI network construction and hub genes identification
Module analysis
Transcriptional factor regulatory network analysis of hub genes
TFs | Genes | Count |
---|---|---|
SPI1 | DNALI1, DNAI2, RSPH4A, RSPH9 | 4 |
SIN3B | ALDH3A1, DNAI2, RSPH4A | 3 |
GATA2 | DNALI1, DNAI2, RSPH9 | 3 |
CREB1 | ALDH3A1, DNAI2 | 2 |
FOXP1 | ALDH3A1, RSPH9 | 2 |
MITF | DNAI2, RSPH9 | 2 |
SALL4 | RSPH4A, RSPH9 | 2 |
SRY | ALDH3A1, RSPH9 | 2 |