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Erschienen in: NeuroTransmitter 10/2018

08.10.2018 | Affektlabilität | Zertifizierte Fortbildung

Komorbidität oder mehr?

Biologische Grundlagen bei ADHS und bipolarer Störung

verfasst von: Dr. med. habil. Sarah Kittel-Schneider

Erschienen in: NeuroTransmitter | Ausgabe 10/2018

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Zusammenfassung

Die Aufmerksamkeitsdefizits-/Hyperaktivitätsstörung (ADHS) und die bipolare Störung sind nicht immer einfach voneinander abzugrenzen, relevante Komorbiditäten sind gut belegt. Derzeit wird diskutiert, ob die Komorbidität von ADHS und bipolarer Störung vielleicht sogar als Subtyp der bipolaren Störung gewertet werden sollte oder sogar als eigene Krankheitsentität. Die Erforschung der genetischen, neurobiologischen und hirnfunktionellen Gemeinsamkeiten und Unterschiede werden aber zukünftig dazu führen, dass die Diagnostik und Behandlung dieser Patienten verbessert werden kann.
Literatur
1.
Zurück zum Zitat Philipsen A, Hesslinger B and L. Tebartz van Elst, Attention deficit hyperactivity disorder in adulthood: diagnosis, etiology and therapy. Dtsch Arztebl Int, 2008. 105(17):311–7PubMedPubMedCentral Philipsen A, Hesslinger B and L. Tebartz van Elst, Attention deficit hyperactivity disorder in adulthood: diagnosis, etiology and therapy. Dtsch Arztebl Int, 2008. 105(17):311–7PubMedPubMedCentral
2.
Zurück zum Zitat Fayyad J et al. Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder. Br J Psychiatry, 2007;190: 402–9CrossRef Fayyad J et al. Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder. Br J Psychiatry, 2007;190: 402–9CrossRef
3.
Zurück zum Zitat Retz-Junginger P et al. Wender Utah rating scale. The short-version for the assessment of the attention-deficit hyperactivity disorder in adults. Nervenarzt 2002. 73(9): 830–8CrossRef Retz-Junginger P et al. Wender Utah rating scale. The short-version for the assessment of the attention-deficit hyperactivity disorder in adults. Nervenarzt 2002. 73(9): 830–8CrossRef
4.
Zurück zum Zitat Gross-Lesch S et al. Sex- and Subtype-Related Differences in the Comorbidity of Adult ADHDs. J Atten Disord. 2016 Oct; 20(10): 855–66CrossRef Gross-Lesch S et al. Sex- and Subtype-Related Differences in the Comorbidity of Adult ADHDs. J Atten Disord. 2016 Oct; 20(10): 855–66CrossRef
5.
Zurück zum Zitat Jacob CP et al. Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center. Eur Arch Psychiatry Clin Neurosci, 2007; 257(6): 309–17CrossRef Jacob CP et al. Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center. Eur Arch Psychiatry Clin Neurosci, 2007; 257(6): 309–17CrossRef
6.
Zurück zum Zitat Ryden E et al. A history of childhood attention-deficit hyperactivity disorder (ADHD) impacts clinical outcome in adult bipolar patients regardless of current ADHD. Acta Psychiatr Scand 2009; 120(3): 239–46CrossRef Ryden E et al. A history of childhood attention-deficit hyperactivity disorder (ADHD) impacts clinical outcome in adult bipolar patients regardless of current ADHD. Acta Psychiatr Scand 2009; 120(3): 239–46CrossRef
7.
Zurück zum Zitat Merikangas KR et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry 2007; 64(5): 543–52CrossRef Merikangas KR et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry 2007; 64(5): 543–52CrossRef
8.
Zurück zum Zitat Brus MJ, Solanto M.V. Goldberg J.F. Adult ADHD vs. bipolar disorder in the DSM-5 era: a challenging differentiation for clinicians. J Psychiatr Pract 2014; 20(6): 428–37CrossRef Brus MJ, Solanto M.V. Goldberg J.F. Adult ADHD vs. bipolar disorder in the DSM-5 era: a challenging differentiation for clinicians. J Psychiatr Pract 2014; 20(6): 428–37CrossRef
9.
Zurück zum Zitat Wilens TE et al. yCan adults with attention-deficit/hyperactivity disorder be distinguished from those with comorbid bipolar disorder? Findings from a sample of clinically referred adults. Biol Psychiatry 2003; 54(1): 1–8CrossRef Wilens TE et al. yCan adults with attention-deficit/hyperactivity disorder be distinguished from those with comorbid bipolar disorder? Findings from a sample of clinically referred adults. Biol Psychiatry 2003; 54(1): 1–8CrossRef
10.
Zurück zum Zitat Goodman DW and M.E. Thase, Recognizing ADHD in adults with comorbid mood disorders: implications for identification and management. Postgrad Med 2009; 121(5): 20–30CrossRef Goodman DW and M.E. Thase, Recognizing ADHD in adults with comorbid mood disorders: implications for identification and management. Postgrad Med 2009; 121(5): 20–30CrossRef
11.
Zurück zum Zitat Richard-Lepouriel H. et al. Similarities between emotional dysregulation in adults suffering from ADHD and bipolar patients. J Affect Disord 2016; 198: 230–6CrossRef Richard-Lepouriel H. et al. Similarities between emotional dysregulation in adults suffering from ADHD and bipolar patients. J Affect Disord 2016; 198: 230–6CrossRef
12.
Zurück zum Zitat McKnight, R.F., et al., Longitudinal mood monitoring in bipolar disorder: Course of illness as revealed through a short messaging service. J Affect Disord 2017; 223: 139–145CrossRef McKnight, R.F., et al., Longitudinal mood monitoring in bipolar disorder: Course of illness as revealed through a short messaging service. J Affect Disord 2017; 223: 139–145CrossRef
13.
Zurück zum Zitat Skirrow C et al. Everyday emotional experience of adults with attention deficit hyperactivity disorder: evidence for reactive and endogenous emotional lability. Psychol Med, 2014; 44(16): 3571–83CrossRef Skirrow C et al. Everyday emotional experience of adults with attention deficit hyperactivity disorder: evidence for reactive and endogenous emotional lability. Psychol Med, 2014; 44(16): 3571–83CrossRef
14.
Zurück zum Zitat Faraone, S.V., et al., Attention-deficit hyperactivity disorder with bipolar disorder: a familial subtype? J Am Acad Child Adolesc Psychiatry, 1997; 36(10): 1378–87; discussion 1387–90CrossRef Faraone, S.V., et al., Attention-deficit hyperactivity disorder with bipolar disorder: a familial subtype? J Am Acad Child Adolesc Psychiatry, 1997; 36(10): 1378–87; discussion 1387–90CrossRef
15.
Zurück zum Zitat McIntyre R., Bipolar disorder and ADHD: Clinical concerns. CNS Spectr 2009; 14(7 Suppl 6): 8–9; discussion 13–4CrossRef McIntyre R., Bipolar disorder and ADHD: Clinical concerns. CNS Spectr 2009; 14(7 Suppl 6): 8–9; discussion 13–4CrossRef
16.
Zurück zum Zitat Bernardi S. et al., Bipolar disorder and comorbid attention deficit hyperactivity disorder. A distinct clinical phenotype? Clinical characteristics and temperamental traits. World J Biol Psychiatry 2010; 11(4): 656–66CrossRef Bernardi S. et al., Bipolar disorder and comorbid attention deficit hyperactivity disorder. A distinct clinical phenotype? Clinical characteristics and temperamental traits. World J Biol Psychiatry 2010; 11(4): 656–66CrossRef
17.
Zurück zum Zitat Wang LJ et al., Attention-deficit hyperactivity disorder, its pharmacotherapy, and the risk of developing bipolar disorder: A nationwide population-based study in Taiwan. J Psychiatr Res 2016; 72: 6–14CrossRef Wang LJ et al., Attention-deficit hyperactivity disorder, its pharmacotherapy, and the risk of developing bipolar disorder: A nationwide population-based study in Taiwan. J Psychiatr Res 2016; 72: 6–14CrossRef
18.
Zurück zum Zitat Duffy A. et al., The developmental trajectory of bipolar disorder. Br J Psychiatry, 2014; 204(2): 122–8CrossRef Duffy A. et al., The developmental trajectory of bipolar disorder. Br J Psychiatry, 2014; 204(2): 122–8CrossRef
19.
Zurück zum Zitat Faraone SV J. Biederman, and J. Wozniak, Examining the comorbidity between attention deficit hyperactivity disorder and bipolar I disorder: a meta-analysis of family genetic studies. Am J Psychiatry 2012; 169(12): 1256–66CrossRef Faraone SV J. Biederman, and J. Wozniak, Examining the comorbidity between attention deficit hyperactivity disorder and bipolar I disorder: a meta-analysis of family genetic studies. Am J Psychiatry 2012; 169(12): 1256–66CrossRef
20.
Zurück zum Zitat Weber H et al. Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD. Neuropsychopharmacology 2011; 36(10): 2076-85CrossRef Weber H et al. Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD. Neuropsychopharmacology 2011; 36(10): 2076-85CrossRef
21.
Zurück zum Zitat Weber H et al. On the role of NOS1 ex1f-VNTR in ADHD-allelic, subgroup, and meta-analysis. Am J Med Genet B Neuropsychiatr Genet 2015; 168(6): 445–458CrossRef Weber H et al. On the role of NOS1 ex1f-VNTR in ADHD-allelic, subgroup, and meta-analysis. Am J Med Genet B Neuropsychiatr Genet 2015; 168(6): 445–458CrossRef
22.
Zurück zum Zitat Lescai F. et al. Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder. Transl Psychiatry 2017; 7(2): e1034CrossRef Lescai F. et al. Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder. Transl Psychiatry 2017; 7(2): e1034CrossRef
23.
Zurück zum Zitat Liu YS et al. The Association of SNAP25 Gene Polymorphisms in Attention Deficit/Hyperactivity Disorder: a Systematic Review and Meta-Analysis. Mol Neurobiol 2017; 54(3): 2189–2200CrossRef Liu YS et al. The Association of SNAP25 Gene Polymorphisms in Attention Deficit/Hyperactivity Disorder: a Systematic Review and Meta-Analysis. Mol Neurobiol 2017; 54(3): 2189–2200CrossRef
24.
Zurück zum Zitat Houenou J et al. A Multilevel Functional Study of a SNAP25 At-Risk Variant for Bipolar Disorder and Schizophrenia. J Neurosci, 2017; 37(43): 0389–10397CrossRef Houenou J et al. A Multilevel Functional Study of a SNAP25 At-Risk Variant for Bipolar Disorder and Schizophrenia. J Neurosci, 2017; 37(43): 0389–10397CrossRef
25.
Zurück zum Zitat Smoller JW et al. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet, 2013; 381(9875): 1371–9CrossRef Smoller JW et al. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet, 2013; 381(9875): 1371–9CrossRef
26.
Zurück zum Zitat van Hulzen KJE. et al. Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis. Biol Psychiatry 2017; 82(9): 634–641CrossRef van Hulzen KJE. et al. Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis. Biol Psychiatry 2017; 82(9): 634–641CrossRef
27.
Zurück zum Zitat Freudenberg FA. Alttoa, and A. Reif, Neuronal nitric oxide synthase (NOS1) and its adaptor, NOS1AP, as a genetic risk factors for psychiatric disorders. Genes Brain Behav 2015; 14(1): 46–63CrossRef Freudenberg FA. Alttoa, and A. Reif, Neuronal nitric oxide synthase (NOS1) and its adaptor, NOS1AP, as a genetic risk factors for psychiatric disorders. Genes Brain Behav 2015; 14(1): 46–63CrossRef
28.
Zurück zum Zitat Maia-de-Oliveira JP. et al. Nitric Oxide’s Involvement in the Spectrum of Psychotic Disorders. Curr Med Chem 2016; 23(24): 2680–2691CrossRef Maia-de-Oliveira JP. et al. Nitric Oxide’s Involvement in the Spectrum of Psychotic Disorders. Curr Med Chem 2016; 23(24): 2680–2691CrossRef
29.
Zurück zum Zitat Selek S. et al. The course of nitric oxide and superoxide dismutase during treatment of bipolar depressive episode. J Affect Disord, 2008; 107(1–3): 89–94CrossRef Selek S. et al. The course of nitric oxide and superoxide dismutase during treatment of bipolar depressive episode. J Affect Disord, 2008; 107(1–3): 89–94CrossRef
30.
Zurück zum Zitat Selek S et al. Probable oxidative imbalance in bipolar depression: The course of nitric oxide and superoxide during the treatment of episode. Bipolar Disorders, 2006; 8: 66–66 Selek S et al. Probable oxidative imbalance in bipolar depression: The course of nitric oxide and superoxide during the treatment of episode. Bipolar Disorders, 2006; 8: 66–66
31.
Zurück zum Zitat Selek S et al., Oxidative imbalance in adult attention deficit/hyperactivity disorder. Biol Psychol 2008; 79(2): 256–9CrossRef Selek S et al., Oxidative imbalance in adult attention deficit/hyperactivity disorder. Biol Psychol 2008; 79(2): 256–9CrossRef
32.
Zurück zum Zitat Nasyrova RF et al. Role of nitric oxide and related molecules in schizophrenia pathogenesis: biochemical, genetic and clinical aspects. Front Physiol 2015; 6: 139CrossRef Nasyrova RF et al. Role of nitric oxide and related molecules in schizophrenia pathogenesis: biochemical, genetic and clinical aspects. Front Physiol 2015; 6: 139CrossRef
33.
Zurück zum Zitat Kittel-Schneider, S. et al. Multi-level biomarker analysis of nitric oxide synthase isoforms in bipolar disorder and adult ADHD. J Psychopharmacol 2015; 29(1): 31–8CrossRef Kittel-Schneider, S. et al. Multi-level biomarker analysis of nitric oxide synthase isoforms in bipolar disorder and adult ADHD. J Psychopharmacol 2015; 29(1): 31–8CrossRef
34.
Zurück zum Zitat Baird AL et al., Adult attention-deficit hyperactivity disorder is associated with alterations in circadian rhythms at the behavioural, endocrine and molecular levels. Mol Psychiatry 2012; 17(10): 988–95CrossRef Baird AL et al., Adult attention-deficit hyperactivity disorder is associated with alterations in circadian rhythms at the behavioural, endocrine and molecular levels. Mol Psychiatry 2012; 17(10): 988–95CrossRef
35.
Zurück zum Zitat Landgraf D. McCarthy M.J., and D.K. Welsh. Circadian clock and stress interactions in the molecular biology of psychiatric disorders. Curr Psychiatry Rep 2014; 16(10): 483CrossRef Landgraf D. McCarthy M.J., and D.K. Welsh. Circadian clock and stress interactions in the molecular biology of psychiatric disorders. Curr Psychiatry Rep 2014; 16(10): 483CrossRef
36.
Zurück zum Zitat Seleem MA et al. The longitudinal course of sleep timing and circadian preferences in adults with bipolar disorder. Bipolar Disord 2015; 17(4): 392–402CrossRef Seleem MA et al. The longitudinal course of sleep timing and circadian preferences in adults with bipolar disorder. Bipolar Disord 2015; 17(4): 392–402CrossRef
37.
Zurück zum Zitat Kittel-Schneider S. et al. Lithium-induced Clock Gene Expression in Lymphoblastoid Cells of Bipolar Affective Patients. Pharmacopsychiatry 2015; 48(4–5): 145–9PubMed Kittel-Schneider S. et al. Lithium-induced Clock Gene Expression in Lymphoblastoid Cells of Bipolar Affective Patients. Pharmacopsychiatry 2015; 48(4–5): 145–9PubMed
38.
Zurück zum Zitat Yang, S et al. Assessment of circadian function in fibroblasts of patients with bipolar disorder. Mol Psychiatry 2009; 14(2): 143–55CrossRef Yang, S et al. Assessment of circadian function in fibroblasts of patients with bipolar disorder. Mol Psychiatry 2009; 14(2): 143–55CrossRef
39.
Zurück zum Zitat Palsson E et al. Cerebrospinal fluid monoamine metabolite profiles in bipolar disorder, ADHD, and controls. J Neural Transm (Vienna) 2017 Sep; 124(9): 1135–1143CrossRef Palsson E et al. Cerebrospinal fluid monoamine metabolite profiles in bipolar disorder, ADHD, and controls. J Neural Transm (Vienna) 2017 Sep; 124(9): 1135–1143CrossRef
40.
Zurück zum Zitat Ryden E., et al., Lower CSF HVA and 5-HIAA in bipolar disorder type 1 with a history of childhood ADHD. J Neural Transm (Vienna), 2009. 116(12): p. 1667–74CrossRef Ryden E., et al., Lower CSF HVA and 5-HIAA in bipolar disorder type 1 with a history of childhood ADHD. J Neural Transm (Vienna), 2009. 116(12): p. 1667–74CrossRef
41.
Zurück zum Zitat Phillips ML and H.A. Swartz. A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research. Am J Psychiatry 2014; 171(8): 829–43CrossRef Phillips ML and H.A. Swartz. A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research. Am J Psychiatry 2014; 171(8): 829–43CrossRef
42.
Zurück zum Zitat Townsend JD et al. Frontal-amygdala connectivity alterations during emotion downregulation in bipolar I disorder. Biol Psychiatry 2013; 73(2): 127–35CrossRef Townsend JD et al. Frontal-amygdala connectivity alterations during emotion downregulation in bipolar I disorder. Biol Psychiatry 2013; 73(2): 127–35CrossRef
43.
Zurück zum Zitat Shaw P et al. Emotion dysregulation in attention deficit hyperactivity disorder. Am J Psychiatry 2014; 171(3): 276–93CrossRef Shaw P et al. Emotion dysregulation in attention deficit hyperactivity disorder. Am J Psychiatry 2014; 171(3): 276–93CrossRef
44.
Zurück zum Zitat Passarotti AM J.A. Sweeney, and M.N. Pavuluri. Differential engagement of cognitive and affective neural systems in pediatric bipolar disorder and attention deficit hyperactivity disorder. J Int Neuropsychol Soc 2010; 16(1): 106–17CrossRef Passarotti AM J.A. Sweeney, and M.N. Pavuluri. Differential engagement of cognitive and affective neural systems in pediatric bipolar disorder and attention deficit hyperactivity disorder. J Int Neuropsychol Soc 2010; 16(1): 106–17CrossRef
45.
Zurück zum Zitat Hafeman D et al. Amygdala-prefrontal cortical functional connectivity during implicit emotion processing differentiates youth with bipolar spectrum from youth with externalizing disorders. J Affect Disord 2017; 208: 94–100CrossRef Hafeman D et al. Amygdala-prefrontal cortical functional connectivity during implicit emotion processing differentiates youth with bipolar spectrum from youth with externalizing disorders. J Affect Disord 2017; 208: 94–100CrossRef
46.
Zurück zum Zitat Townsend JD et al. Frontostriatal neuroimaging findings differ in patients with bipolar disorder who have or do not have ADHD comorbidity. J Affect Disord 2013; 147(1–3): 389–96CrossRef Townsend JD et al. Frontostriatal neuroimaging findings differ in patients with bipolar disorder who have or do not have ADHD comorbidity. J Affect Disord 2013; 147(1–3): 389–96CrossRef
47.
Zurück zum Zitat Asherson P et al. Differential diagnosis, comorbidity, and treatment of attention-deficit/hyperactivity disorder in relation to bipolar disorder or borderline personality disorder in adults. Curr Med Res Opin 2014; 30(8): 1657–72CrossRef Asherson P et al. Differential diagnosis, comorbidity, and treatment of attention-deficit/hyperactivity disorder in relation to bipolar disorder or borderline personality disorder in adults. Curr Med Res Opin 2014; 30(8): 1657–72CrossRef
48.
Zurück zum Zitat Viktorin A et al. The Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder. Am J Psychiatry 2017; 174(4): 341–348CrossRef Viktorin A et al. The Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder. Am J Psychiatry 2017; 174(4): 341–348CrossRef
49.
Zurück zum Zitat Szmulewicz AG et al. Dopaminergic agents in the treatment of bipolar depression: a systematic review and meta-analysis. Acta Psychiatr Scand 2017; 135(6): 527–538CrossRef Szmulewicz AG et al. Dopaminergic agents in the treatment of bipolar depression: a systematic review and meta-analysis. Acta Psychiatr Scand 2017; 135(6): 527–538CrossRef
50.
Zurück zum Zitat Geissler J et al. Hyperactivity and sensation seeking as autoregulatory attempts to stabilize brain arousal in ADHD and mania? Atten Defic Hyperact Disord 2014; 6(3): 159–73CrossRef Geissler J et al. Hyperactivity and sensation seeking as autoregulatory attempts to stabilize brain arousal in ADHD and mania? Atten Defic Hyperact Disord 2014; 6(3): 159–73CrossRef
51.
Zurück zum Zitat Hegerl U et al. A multi-centre,randomised, double-blind, placebo-controlled clinical trial of methylphenidate in the initial treatment of acute mania (MEMAP study). Eur Neuropsychopharmacol 2018; 28(1): 185–194CrossRef Hegerl U et al. A multi-centre,randomised, double-blind, placebo-controlled clinical trial of methylphenidate in the initial treatment of acute mania (MEMAP study). Eur Neuropsychopharmacol 2018; 28(1): 185–194CrossRef
Metadaten
Titel
Komorbidität oder mehr?
Biologische Grundlagen bei ADHS und bipolarer Störung
verfasst von
Dr. med. habil. Sarah Kittel-Schneider
Publikationsdatum
08.10.2018
Verlag
Springer Medizin
Schlagwörter
Affektlabilität
ADHS
ADHS
Erschienen in
NeuroTransmitter / Ausgabe 10/2018
Print ISSN: 1436-123X
Elektronische ISSN: 2196-6397
DOI
https://doi.org/10.1007/s15016-018-6216-0

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