Skip to main content
main-content

01.01.2012 | Review | Ausgabe 1/2012

International Archives of Occupational and Environmental Health 1/2012

Biomarkers of chromosomal damage in peripheral blood lymphocytes induced by polycyclic aromatic hydrocarbons: a meta-analysis

Zeitschrift:
International Archives of Occupational and Environmental Health > Ausgabe 1/2012
Autoren:
Yadong Wang, Haiyan Yang, Li Li, Haiyu Wang, Xiangqun Xia, Congke Zhang
Wichtige Hinweise
Y. Wang and H. Yang contributed equally to this work.

Abstract

Background

A crucial early event in polycyclic aromatic hydrocarbons (PAHs) carcinogenesis is the induction of genomic instability phenotype that initiates the progression of a proliferative cell into a cancer cell. However, epidemiological results have been inconsistent.

Objectives

To assess reported studies of associations between the levels of chromosomal damage including sister chromatid exchange (SCE), chromosomal aberrations (CA), and cytokinesis-block micronucleus (CBMN) in peripheral blood lymphocytes and occupational exposure to PAHs.

Methods

Meta-analysis on the association between chromosomal damage and occupational exposure to PAHs was performed with STATA 10.0 software package and Review Manager 4.2.10 in this study.

Results

We found statistically significant differences in the frequencies of SCE, CBMN, and CA (aberrations per 100 cells) in peripheral blood lymphocytes between PAHs-exposed group and control group, and the summary estimates of weighted mean difference were 1.42 (95% CI: 0.82–2.02), 1.22 (95% CI: 0.33–2.10), and 0.96 (95% CI: 0.37–1.56), respectively.

Conclusions

Data indicate that the frequencies of SCE, CBMN, and CA (aberrations per 100 cells) in peripheral blood lymphocytes might be indicators of early genetic effects for occupationally PAHs-exposed population.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Jetzt e.Med zum Sonderpreis bestellen!

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2012

International Archives of Occupational and Environmental Health 1/2012 Zur Ausgabe