PEV serves on a scientific advisory board and received funding for travel and speaker honoraria from Ever Neuro Pharma; serves as a member of the editorial advisory board of The European Journal of Neurology; and has received honoraria for lectures or educational activities not funded by the industry.
Traumatic brain injury (TBI) is a pathologically heterogeneous disease affecting people of all ages. The highest incidence of TBI occurs in young people and the average age is 30 to 40 years. Injury grading may range from mild with a low frequency (1 per 100) of life-threatening intracranial hematoma that needs immediate neurosurgical operation and very low mortality (1 per 1,000) to severe with a high likelihood of life-threatening intracranial hematoma (up to 1 per 3), a 40% case fatality rate and a high disability rate (2 per 3) in survivors. Estimation of the prognosis in severe TBI is currently based on demographic and clinical predictors, including age, Glasgow Coma Scale, pupillary reactions, extracranial injury (hypotension and hypoxia) and computed tomography indices (brain swelling, focal mass lesions, subarachnoid hemorrhage). Biomarkers reflecting damage to neurons and astrocytes may add important complementary information to clinical predictors of outcome and provide insight into the pathophysiology of TBI.
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Mondello S, Papa L, Buki A, Bullock R, Czeiter E, Tortella F, Wang KK, Hayes RL: Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study. Crit Care. 2011, 15: R156-10.1186/cc10286. PubMedPubMedCentralCrossRef
Steyerberg EW, Mushkudiani N, Perel P, Butcher I, Lu J, McHugh GS, Murray GD, Marmarou A, Roberts I, Habbema JD, Maas AI: Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. PLoS Med. 2008, 5: e165-10.1371/journal.pmed.0050165. PubMedPubMedCentralCrossRef
MRC CRASH Trial Collaborators, Perel P, Arango M, Clayton T, Edwards P, Komolafe E, Poccock S, Roberts I, Shakur H, Steyerberg E, Yutthakasemsunt S: Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients. BMJ. 2008, 336: 425-429. PubMedCentralCrossRef
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- Biomarkers of focal and diffuse traumatic brain injury
Pieter E Vos
- BioMed Central
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