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Graefe's Archive for Clinical and Experimental Ophthalmology

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09.11.2020 | Cornea

Biomechanical properties of the cornea following intravitreal ranibizumab injection

verfasst von: Sinan Bekmez, Harun Cakmak, Tolga Kocaturk, Fulden Cantas, Sema Dundar

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 3/2021

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Abstract

Objective

To evaluate intraocular pressure (IOP) and corneal biomechanical properties changes after intravitreal ranibizumab injection (IVRI).

Methods

One hundred twenty eyes of 120 patients who underwent IVRI between January and March 2018 in Adnan Menderes University Ophthalmology Clinic were included in study. Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) were measured by Ocular Response Analyzer (ORA) by the same specialist preoperatively (preop), postoperative 1st (postop-1st), postoperative 3rd (postop-3rd), and postoperative 24th hours (postop-24th) after single-dose IVRI.

Results

Among the 120 wet age-related macular degeneration subjects, 58 (48.3%) were female and 62 (51.7%) were male. The mean age was 64.8 ± 10.4 years. Postop-1st hour IOP cc and IOPg measurements were statistically different from all other measurements (p < 0.001). Postop-1st hour CH measurements were statistically different from preop and postop-3rd (p = 0.022 and p = 0.008, respectively).

Conclusion

After intravitreal injection, IOP pressures significantly increased. But, CH and CRF values were significantly decreased. All these changes were temporary.

Ambati J, Atkinson JP, Gelfand BD (2013) Immunology of age-related macular degeneration. Nat Rev Immunol 13(6):438–451CrossRef

Qin VL, Young J, Silva FQ, Conti FF, Singh RP (2018) Outcomes of patients with exudative age-related macular degeneration treated with antivascular endothelial growth factor therapy for three or more years: a review of current outcomes. Retina. 38(8):1500–1508CrossRef

Peden MC, Suñer IJ, Hammer ME, Grizzard WS (2015) Long-term outcomes in eyes receiving fixed-interval dosing of anti-vascular endothelial growth factor agents for wet age-related macular degeneration. Ophthalmology. 122(4):803–808CrossRef

McCannel CA (2011) Meta-analysis of endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents. Retina. 31:654–661CrossRef

Tolentino M (2011) Systemic and ocular safety of intravitreal anti-VEGF therapies for ocular neovascular disease. Surv Ophthalmol 56:95–113CrossRef

Bakri SJ, Pulido JS, McCannel CA, Hodge DO, Diehl N, Hillemeier J (2009) Immediate intraocular pressure changes following intravitreal injections of triamcinolone, pegaptanib, and bevacizumab. Eye. 23(1):181–185CrossRef

Gismondi M, Salati C, Salvetat ML, Zeppieri M, Brusini P (2009) Short-term effect of intravitreal injection of ranibizumab (Lucentis) on intraocular pressure. J Glaucoma 18(9):658–661CrossRef

Ladas ID, Karagiannis DA, Rouvas AA, Kotsolis AI, Liotsou A, Vergados I (2009) Safety of repeat intravitreal injections of bevacizumab versus ranibizumab: our experience after 2,000 injections. Retina. 29(3):313–318CrossRef

ElMallah MK, Asrani SG (2008) New ways to measure intraocular pressure. Curr Opin Ophthalmol 19(2):122–126CrossRef

10.

Al-Mubrad TM, Ogbuehi KC (2007) Clinical investigation of the effect of topical anesthesia on intraocular pressure. Clin Ophthalmol 1(3):305–309

11.

Whitacre MM, Stein R (1993) Sources of error with use of Goldmann-type tonometers. Surv Ophthalmol 38(1):1–30CrossRef

12.

Luce DA (2005) Determining in vivo biomechanical properties of the cornea with an ocular response analyzer. J Cataract Refract Surg 31:156–162CrossRef

13.

Wasielica-Poslednik J, Berisha F, Aliyeva S, Pfeiffer N, Hoffmann EM (2010) Reproducibility of ocular response analyzer measurements and their correlation with central corneal thickness. Graefes Arch Clin Exp Ophthalmol 248(11):1617–1622CrossRef

14.

Medeiros FA, Meira-Freitas D, Lisboa R, Kuang TM, Zangwill LM, Weinreb RN (2013) Corneal hysteresis as a risk factor for glaucoma progression: a prospective longitudinal study. Ophthalmology. 120(8):1533–1540CrossRef

15.

Kirgiz A, Karaman Erdur S, Atalay K, Gurez C (2019) The role of ocular response analyzer in differentiation of forme fruste keratoconus from corneal astigmatism. Eye Contact Lens 45:83–87CrossRef

16.

Congdon NG, Broman AT, Bandeen-Roche K, Grover D, Quigley HA (2006) Central corneal thickness and corneal hysteresis associated with glaucoma damage. Am J Ophthalmol 141:868–875CrossRef

17.

Pepose JS, Feigenbaum SK, Qazi MA, Sanderson JP, Roberts CJ (2007) Changes in corneal biomechanics and intraocular pressure following LASIK using static, dynamic, and noncontact tonometry. Am J Ophthalmol 143(1):39–47CrossRef

18.

Brown DM, Michels M, Kaiser PK, Heier JS, Sy JP, Ianchulev T (2009) Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR study. Ophthalmology. 116(1):57–65CrossRef

19.

Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY (2006) Ranibizumab for neovascular agerelated macular degeneration. N Engl J Med 355(14):1419–1431CrossRef

20.

Park J, Lee M (2018) Short-term effects and safety of an acute increase of intraocular pressure after intravitreal bevacizumab injection on corneal endothelial cells. BMC Ophthalmol 18(1):17CrossRef

21.

SooHoo JR, Seibold LK, Kahook MY (2014) The link between intravitreal antivascular endothelial growth factor injections and glaucoma. Curr Opin Ophthalmol 25(2):127–133CrossRef

22.

Sternfeld A, Ehrlich R, Weinberger D, Dotan A (2020) Effect of different lens status on intraocular pressure elevation in patients treated with anti-vascular endothelial growth factor injections. Int J Ophthalmol 13(1):79–84CrossRef

23.

Arslan GD, Guven D, Alkan AA, Kacar H, Demir M (2019) Short term effects of intravitreal anti-vascular endothelial growth factor agents on cornea, anterior chamber, and intraocular pressure. Cutan Ocul Toxicol 38(4):344–348CrossRef

24.

Bakri SJ, Snyder MR, Reid JM, Pulido JS, Ezzak MK, Singh RJ (2007) Pharmacokinetics of intravitreal ranibizumab (Lucentis). Ophthalmology. 114(12):2179–2182CrossRef

25.

Hollands H, Wong J, Bruen R, Campbell RJ, Sharma S, Gale J (2007) Short-term intraocular pressure changes after intravitreal injection of bevacizumab. Can J Ophthalmol 42:807–811CrossRef

26.

Kahook MY, Kimura AE, Wong LJ, Ammar DA, Maycotte MA, Mandava N (2009) Sustained elevation in intraocular pressure associated with intravitreal bevacizumab injections. Ophthalmic Surg Lasers Imaging 40:293–295CrossRef

27.

Hoang QV, Mendonca LS, Della Torre KE, Jung JJ, Tsuang AJ, Freund KB (2012) Effect on intraocular pressure in patients receiving unilateral intravitreal anti-vascular endothelial growth factor injections. Ophthalmology. 119:321–326CrossRef

28.

Shoeibi N, Ansari-Astaneh MR, Sedaghat MR, Shokoohi RS (2019) Effect of intravitreal bevacizumab injection on corneal in vivo biomechanics: a pilot study. J Ophthalmic Vis Res 14(2):151–156CrossRef

29.

Sniegowski M, Mandava N, Kahook MY (2010) Sustained intraocular pressure elevation after intravitreal injection of bevacizumab and ranibizumab associated with trabeculitis. Open Ophthalmol J 4:28–29CrossRef

30.

Mitchell P, Korobelnik JF, Lanzetta P, Holz FG, Prünte C, Schmidt-Erfurth U, Tano Y, Wolf S (2010) Ranibizumab (Lucentis) in neovascular age-related macular degeneration: evidence from clinical trials. Br J Ophthalmol 94(1):2–13CrossRef

31.

Susanna CN, Diniz-Filho A, Daga FB, Susanna BN, Zhu F, Ogata NG, Medeiros FA (2018) A prospective longitudinal study to investigate corneal hysteresis as a risk factor for predicting development of glaucoma. Am J Ophthalmol 187:148–152CrossRef

32.

Zhang C, Tatham AJ, Abe RY, Diniz-Filho A, Zangwill LM, Weinreb RN, Medeiros FA (2016) Corneal hysteresis and progressive retinal nerve fiber layer loss in glaucoma. Am J Ophthalmol 166:29–36CrossRef

33.

Fontes BM, Ambrósio R Jr, Velarde GC, Nosé W (2011) Corneal biomechanical evaluation in healthy thin corneas compared with matched keratoconus cases. Arq Bras Oftalmol 74:13–16CrossRef

34.

Kamiya K, Hagishima M, Fujimura F, Shimizu K (2008) Factors affecting corneal hysteresis in normal eyes. Graefes Arch Clin Exp Ophthalmol 246:1491–1494CrossRef

Titel: Biomechanical properties of the cornea following intravitreal ranibizumab injection
verfasst von: Sinan Bekmez
Harun Cakmak
Tolga Kocaturk
Fulden Cantas
Sema Dundar
Publikationsdatum: 09.11.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 3/2021
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-05001-2

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Biomechanical properties of the cornea following intravitreal ranibizumab injection

Abstract

Objective

Methods

Results

Conclusion

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

Bestmögliche Wundheilung der Kornea dank optimaler pharmakologischer Therapie

Update Augenheilkunde

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objective

Methods

Results

Conclusion

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