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01.10.2018 | Original Article

Biophysical skin measurements to evaluate the effectiveness of photobiomodulation therapy in the prevention of acute radiation dermatitis in breast cancer patients

verfasst von: Jolien Robijns, Sandrine Censabella, Stefan Claes, Luc Pannekoeke, Lore Bussé, Dora Colson, Iris Kaminski, Joy Lodewijckx, Paul Bulens, Annelies Maes, Leen Noé, Marc Brosens, An Timmermans, Ivo Lambrichts, Veerle Somers, Jeroen Mebis

Erschienen in: Supportive Care in Cancer | Ausgabe 4/2019

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Abstract

Purpose

The purpose of this study was to evaluate objectively the effectiveness of photobiomodulation therapy (PBMT) for the prevention of acute radiation dermatitis (ARD) by using biophysical skin measurements.

Methods

A randomized, placebo-controlled trial with 120 breast cancer patients who underwent an identical radiotherapy (RT) regimen post-lumpectomy was performed (TRANSDERMIS trial). Patients were randomized to receive PBM (808 nm CW/905 nm pulsed, 168 mW/cm², spot size 19.6 cm², fluence 4 J/cm²) or placebo treatments from the first day of RT (2×/week). Biophysical skin measurements were collected to assess the skin pigmentation and barrier function. Measurements were collected at the first day of RT, a RT dose of 40 Gray (Gy), and the end of RT (66 Gy).

Results

The incidence of moist desquamation was significantly higher in the control than in the PBMT group at the end of RT (30 vs. 7%, respectively, odds ratio = 6, p = 0.004). The biophysical skin measures showed that the mean percentage change from the baseline transepidermal water loss (TEWL), erythema, and melanin values was significantly higher in the control than in the PBMT group at the end of RT (ps < 0.05). Logistic regression analysis revealed that the risk on moist desquamation was significantly increased for patients with a large (> 800 cc) breast volume (odds ratio = 4, p = 0.017).

Conclusions

This is the first randomized controlled trial demonstrating by objective measurements that PBMT is effective in reducing the incidence of moist desquamation in breast cancer patients undergoing RT. Additionally, a large breast volume is an important risk factor for the development of moist desquamation.

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DIBH was used when the patients matched the following criteria: bilateral breast cancer; left-sided breast cancer and lymph node metastases under the age of 70 years; left-sided breast cancer and lymph node metastases above the age of 70 years and undergoing chemotherapy; left-sided breast cancer without lymph node metastasis but with a MHD ≥ 35 Gy. DIBH was applied using the Varian Real-Time Position Management (RPM) gating system (Varian Medical System, Palo Alto, CA).

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Titel: Biophysical skin measurements to evaluate the effectiveness of photobiomodulation therapy in the prevention of acute radiation dermatitis in breast cancer patients
verfasst von: Jolien Robijns
Sandrine Censabella
Stefan Claes
Luc Pannekoeke
Lore Bussé
Dora Colson
Iris Kaminski
Joy Lodewijckx
Paul Bulens
Annelies Maes
Leen Noé
Marc Brosens
An Timmermans
Ivo Lambrichts
Veerle Somers
Jeroen Mebis
Publikationsdatum: 01.10.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 4/2019
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-018-4487-4

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Springer Medizin

Biophysical skin measurements to evaluate the effectiveness of photobiomodulation therapy in the prevention of acute radiation dermatitis in breast cancer patients

Abstract

Purpose

Methods

Results

Conclusions

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Abstract

Purpose

Methods

Results

Conclusions

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