The online version of this article (doi:10.1186/1471-2261-14-109) contains supplementary material, which is available to authorized users.
Dr. Estruch reports serving on the board of and receiving lecture fees from the Research Foundation on Wine and Nutrition (FIVIN), serving on the boards of the Beer and Health Foundation and the European Foundation for Alcohol Research (ERAB), receiving lecture fees from Cerveceros de España and Sanofi-Aventis, and receiving grant support through his institution from Novartis. Dr.Salas-Salvadó reports serving on the board of and receiving grant support through his institution from the International Nut and Dried Fruit Council, receiving consulting fees from Danone, and receiving grant support through his institution from Eroski and Nestlé. Dr. Arós reports receiving payment for the development of educational presentations from Menarini and AstraZeneca. Dr. Serra-Majem reports serving on the boards of the Mediterranean Diet Foundation and the Beer and Health Foundation. Dr. Pintó reports serving on the board of and receiving grant support through his institution from the Residual Risk Reduction Initiative (R3i) Foundation, serving on the board of Omegafort, serving on the board of and receiving payment for the development of educational presentations, as well as grant support through his institution, from Ferrer, receiving consulting fees from Abbott Laboratories, receiving lecture fees, as well as grant support through his institution, from Merck and Roche receiving lecture fees from Danone and Esteve, receiving payment for the development of educational presentations from Menarini, and receiving grant support through his institution from Sanof i-Aventis, Kowa, Unilever, Boehringer Ingelheim, and Karo Bio. No other potential conflict of interest relevant to this article was reported.
CM-L and MAM. conceived and designed the study. They also analyzed and interpreted the study data, and wrote the first draft of the manuscript. RE, MAM-G., JS.-S, DC, EG-G, M.F, JL, M.Fitó, FA, LS.-M, XP., JB, JVS, assisted in the acquisition of data and provided valuable, intellectual contributions to the manuscript draft. All authors have approval the final version submitted for publication.
Hypertension and depression are both important risk factors for cardiovascular diseases. Nevertheless, the association of blood pressure on and depression has not been completely established. This study aims to analyze whether depression may influence the control of blood pressure in hypertensive individuals at high cardiovascular risk.
Cross-sectional study, embedded within the PREDIMED clinical trial, of 5954 hypertensive patients with high cardiovascular risk factor profiles. The relationship between blood pressure control and depression was analyzed. A multivariate analysis (logistic and log-linear regression), adjusting for potential confounders (socio-demographic factors, body mass index, lifestyle, diabetes, dyslipidemia, and antihypertensive treatment), was performed.
Depressive patients, with and without antidepressant treatment, had better blood pressure control (OR: 1.28, CI 95%: 1.06-1.55, and OR: 1.30, CI 95%: 1.03-1.65, respectively) than non-depressive ones. Regarding blood pressure levels, systolic blood pressure values (mmHg) were found to be lower in both treated and untreated depressive patients (Log coefficient Beta: -1.59, 95% CI: -0.50 to -2.69 and Log coefficient Beta: -3.49, 95% CI: -2.10 to -4.87, respectively).
Among hypertensive patients at high cardiovascular risk, the control of blood pressure was better in those diagnosed with depression.
Unique identifier: ISRCTN35739639.
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- Blood pressure values and depression in hypertensive individuals at high cardiovascular risk
Miguel Angel Martínez-González
José Manuel Santos
José Vicente Sorlí
the PREDIMED Study Investigators
- BioMed Central
Neu im Fachgebiet Kardiologie
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