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BMC Cancer

Ausgabe 1/2007

Inhalt (237 Artikel)

Improving the quality and efficiency of follow-up after curative treatment for breast cancer – rationale and study design of the MaCare trial

  • Open Access
  • Study protocol

Merel L Kimman, Adri C Voogd, Carmen D Dirksen, Paul Falger, Pierre Hupperets, Kristien Keymeulen, Marlene Hebly, Cary Dehing, Philippe Lambin, Liesbeth J Boersma

Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers

  • Open Access
  • Research article

Rosalyn D Blumenthal, Evelyn Leon, Hans J Hansen, David M Goldenberg

Oesophageal cancer mortality in Spain: a spatial analysis

  • Open Access
  • Research article

Nuria Aragonés, Rebeca Ramis, Marina Pollán, Beatriz Pérez-Gómez, Diana Gómez-Barroso, Virginia Lope, Elena Isabel Boldo, Javier García-Pérez, Gonzalo López-Abente

Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model

  • Open Access
  • Research article

Gilda G Hillman, Yu Wang, Mingxin Che, Julian J Raffoul, Mark Yudelev, Omer Kucuk, Fazlul H Sarkar

Expression of the Na+/l-symporter (NIS) is markedly decreased or absent in gastric cancer and intestinal metaplastic mucosa of Barrett esophagus

  • Open Access
  • Research article

Áron Altorjay, Orsolya Dohán, Anna Szilágyi, Monika Paroder, Irene L Wapnir, Nancy Carrasco

A procedure for the detection of linkage with high density SNP arrays in a large pedigree with colorectal cancer

  • Open Access
  • Research article

Anneke Middeldorp, Shantie Jagmohan-Changur, Quinta Helmer, Heleen M van der Klift, Carli MJ Tops, Hans FA Vasen, Peter Devilee, Hans Morreau, Jeanine J Houwing-Duistermaat, Juul T Wijnen, Tom van Wezel

Lymphatic vessels assessment in feline mammary tumours

  • Open Access
  • Research article

Giuseppe Sarli, Francesco Sassi, Barbara Brunetti, Antonio Rizzo, Laura Diracca, Cinzia Benazzi

Anti-tumor effect of bisphosphonate (YM529) on non-small cell lung cancer cell lines

  • Open Access
  • Research article

Ryuichiro Koshimune, Motoi Aoe, Shinichi Toyooka, Fumikata Hara, Mamoru Ouchida, Masaki Tokumo, Yoshifumi Sano, Hiroshi Date, Nobuyoshi Shimizu

Increased cardiovascular mortality more than fifteen years after radiotherapy for breast cancer: a population-based study

  • Open Access
  • Research article

Rahul Roychoudhuri, David Robinson, Venkata Putcha, Jack Cuzick, Sarah Darby, Henrik Møller

Cancer mortality trends in the Umbria region of Italy 1978–2004: a joinpoint regression analysis

  • Open Access
  • Research article

Fabrizio Stracci, Antonio Canosa, Liliana Minelli, Anna Maria Petrinelli, Tiziana Cassetti, Carlo Romagnoli, Francesco La Rosa

Metabolic mapping by use of high-resolution magic angle spinning 1H MR spectroscopy for assessment of apoptosis in cervical carcinomas

  • Open Access
  • Research article

Heidi Lyng, Beathe Sitter, Tone F Bathen, Line R Jensen, Kolbein Sundfør, Gunnar B Kristensen, Ingrid S Gribbestad

Stromelysin-3 over-expression enhances tumourigenesis in MCF-7 and MDA-MB-231 breast cancer cell lines: involvement of the IGF-1 signalling pathway

  • Open Access
  • Research article

Grit Kasper, Matthias Reule, Miriam Tschirschmann, Niels Dankert, Karen Stout-Weider, Roland Lauster, Evelin Schrock, Detlev Mennerich, Georg N Duda, Kerstin E Lehmann

Severe paraneoplastic hypoglycemia in a patient with a gastrointestinal stromal tumor with an exon 9 mutation: a case report

  • Open Access
  • Case report

Guillermo A Escobar, William A Robinson, Trevor L Nydam, Drew C Heiple, Glen J Weiss, Linda Buckley, Rene Gonzalez, Martin D McCarter

A novel BRCA-1 mutation in Arab kindred from east Jerusalem with breast and ovarian cancer

  • Open Access
  • Research article

Luna Kadouri, Dani Bercovich, Arava Elimelech, Israela Lerer, Michal Sagi, Gila Glusman, Chen Shochat, Sigal Korem, Tamar Hamburger, Aviram Nissan, Nahil Abu-Halaf, Muhmud Badrriyah, Dvorah Abeliovich, Tamar Peretz

P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling

  • Open Access
  • Research article

Kiyosumi Shibata, Hiroaki Kajiyama, Kazuhiko Ino, Akihiro Nawa, Seiji Nomura, Shigehiko Mizutani, Fumitaka Kikkawa

GSTT2 promoter polymorphisms and colorectal cancer risk

  • Open Access
  • Research article

Sang-Geun Jang, Il-Jin Kim, Hio Chung Kang, Hye-Won Park, Sun-A Ahn, Hyun-Ju Yoon, Kun Kim, Hai-Rim Shin, Jin Soo Lee, Jae-Gahb Park

FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders

  • Open Access
  • Research article

Gennaro Chiappetta, Angelo Ferraro, Gerardo Botti, Mario Monaco, Rosa Pasquinelli, Emilia Vuttariello, Liliane Arnaldi, Maurizio Di Bonito, Giuseppe D'Aiuto, Giovanna Maria Pierantoni, Alfredo Fusco

Concomitant treatment of brain metastasis with Whole Brain Radiotherapy [WBRT] and Temozolomide [TMZ] is active and improves Quality of Life

  • Open Access
  • Research article

Raffaele Addeo, Michele Caraglia, Vincenzo Faiola, Elena Capasso, Bruno Vincenzi, Liliana Montella, Rosario Guarrasi, Luigi Caserta, Salvatore Del Prete

Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells

  • Open Access
  • Research article

André O von Bueren, Tarek Shalaby, Julia Rajtarova, Duncan Stearns, Charles G Eberhart, Lawrence Helson, Alexandre Arcaro, Michael A Grotzer

Mandatory chromosomal segment balance in aneuploid tumor cells

  • Open Access
  • Research article

Maria Kost-Alimova, Eva Darai-Ramqvist, Wing Lung Yau, Agneta Sandlund, Ludmila Fedorova, Ying Yang, Irina Kholodnyuk, Yue Cheng, Maria Li Lung, Eric Stanbridge, George Klein, Stefan Imreh

Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK 4 and inactivation of MMP-2

  • Open Access
  • Research article

Yulan Liu, Ling Xi, Guoning Liao, Wei Wang, Xun Tian, Beibei Wang, Gang Chen, Zhiqiang Han, Mingfu Wu, Shixuan Wang, Jianfeng Zhou, Gang Xu, Yunping Lu, Ding Ma

Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors

  • Open Access
  • Research article

Anette Raa, Christine Stansberg, Vidar M Steen, Rolf Bjerkvig, Rolf K Reed, Linda EB Stuhr

E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation

  • Open Access
  • Research article

Hongying Hao, Yanbin Dong, Maria T Bowling, Jorge G Gomez-Gutierrez, H Sam Zhou, Kelly M McMasters

Classification tree analysis of second neoplasms in survivors of childhood cancer

  • Open Access
  • Research article

Janez Jazbec, Ljupčo Todorovski, Berta Jereb

The progressive elevation of alpha fetoprotein for the diagnosis of hepatocellular carcinoma in patients with liver cirrhosis

  • Open Access
  • Research article

Oscar Arrieta, Bernardo Cacho, Daniela Morales-Espinosa, Ana Ruelas-Villavicencio, Diana Flores-Estrada, Norma Hernández-Pedro

Caspase-dependent proteolytic cleavage of STAT3α in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines

  • Open Access
  • Research article

James R Matthews, Susan MR Watson, Maxine CL Tevendale, Christine J Watson, Alan R Clarke

Breast density and polymorphisms in genes coding for CYP1A2 and COMT: the Multiethnic Cohort

  • Open Access
  • Research article

Yumie Takata, Gertraud Maskarinec, Loïc Le Marchand

Disease-specific survival for limited-stage small-cell lung cancer affected by statistical method of assessment

  • Open Access
  • Research article

Patricia Tai, Judith-Anne W Chapman, Edward Yu, Dennie Jones, Changhong Yu, Fei Yuan, Lee Sang-Joon

Erratum to: Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functional molecular study

  • Open Access
  • Erratum

Kam-Meng Tchou-Wong, Sandra YY Fok, Jeffrey S Rubin, Fiona Pixley, John Condeelis, Filip Braet, William Rom, Lilian L Soon

HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression

  • Open Access
  • Research article

Jan Willem F Dierssen, Noel FCC de Miranda, Soldano Ferrone, Marjo van Puijenbroek, Cees J Cornelisse, Gert Jan Fleuren, Tom van Wezel, Hans Morreau

Distinct mechanisms of loss of IFN-gamma mediated HLA class I inducibility in two melanoma cell lines

  • Open Access
  • Research article

Teresa Rodríguez, Rosa Méndez, Ana Del Campo, Pilar Jiménez, Natalia Aptsiauri, Federico Garrido, Francisco Ruiz-Cabello

Growth regulation of simian and human AIDS-related non-Hodgkin's lymphoma cell lines by TGF-β1 and IL-6

  • Open Access
  • Research article

Kristin R Ruff, Adriane Puetter, Laura S Levy

HER-2, p53, p21 and hormonal receptors proteins expression as predictive factors of response and prognosis in locally advanced breast cancer treated with neoadjuvant docetaxel plus epirubicin combination

  • Open Access
  • Research article

Daniel G Tiezzi, Jurandyr M Andrade, Alfredo Ribeiro-Silva, Fábio E Zola, Heitor RC Marana, Marcelo G Tiezzi

Availability and quality of paraffin blocks identified in pathology archives: A multi-institutional study by the Shared Pathology Informatics Network (SPIN)

  • Open Access
  • Research article

Ashokkumar A Patel, Dilipkumar Gupta, David Seligson, Eyas M Hattab, Ulysses J Balis, Thomas M Ulbright, Isaac S Kohane, Jules J Berman, John R Gilbertson, Sarah Dry, Osvaldo Schirripa, Hong Yu, Michael J Becich, Anil V Parwani

Primary small cell carcinoma of the esophagus: clinicopathological and immunohistochemical features of 21 cases

  • Open Access
  • Research article

Jing-Ping Yun, Mei-Fang Zhang, Jin-Hui Hou, Qiu-Hong Tian, Jia Fu, Xiao-Man Liang, Qiu-Liang Wu, Tie-Hua Rong

A new molecular breast cancer subclass defined from a large scale real-time quantitative RT-PCR study

  • Open Access
  • Research article

Maïa Chanrion, Hélène Fontaine, Carmen Rodriguez, Vincent Negre, Frédéric Bibeau, Charles Theillet, Alain Hénaut, Jean-Marie Darbon

Response of lymphocyte subsets and cytokines to Shenyang prescription in Sprague-Dawley rats with tongue squamous cell carcinomas induced by 4NQO

  • Open Access
  • Research article

Canhua Jiang, Dongxia Ye, Weiliu Qiu, Xiuli Zhang, Zhiyuan Zhang, Di He, Ping Zhang, Wantao Chen

Leucine-rich diet alters the eukaryotic translation initiation factors expression in skeletal muscle of tumour-bearing rats

  • Open Access
  • Research article

Gislaine Ventrucci, Maria Alice R Mello, Maria Cristina C Gomes-Marcondes

Automated array-CGH optimized for archival formalin-fixed, paraffin-embedded tumor material

  • Open Access
  • Technical advance

Simon A Joosse, Erik H van Beers, Petra M Nederlof

Qualitative and quantitative dermatoglyphic traits in patients with breast cancer: a prospective clinical study

  • Open Access
  • Research article

Chintamani, Rohan Khandelwal, Aliza Mittal, Sai Saijanani, Amita Tuteja, Anju Bansal, Dinesh Bhatnagar, Sunita Saxena

Association of IL-1beta gene polymorphism with cachexia from locally advanced gastric cancer

  • Open Access
  • Research article

Dianliang Zhang, Hongmei Zheng, Yanbing Zhou, Xingming Tang, Baojun Yu, Jieshou Li

Giant cell tumor of the uterus: case report and response to chemotherapy

  • Open Access
  • Case report

Keith M Skubitz, Js Carlos Manivel

Up-regulation of expression and lack of 5' CpG island hypermethylation of p16 INK4ain HPV-positive cervical carcinomas

  • Open Access
  • Research article

Tatiana A Ivanova, Daria A Golovina, Larisa E Zavalishina, Galina M Volgareva, Alexey N Katargin, Yulia Y Andreeva, Georgy A Frank, Fjodor L Kisseljov, Natalia P Kisseljova

Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population

  • Open Access
  • Research article

Emin T Elkiran, Nefsal Mar, Bilge Aygen, Ferit Gursu, Aziz Karaoglu, Suleyman Koca

Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo

  • Open Access
  • Research article

Frank M Klenke, Amir Abdollahi, Elisabeth Bertl, Martha-Maria Gebhard, Volker Ewerbeck, Peter E Huber, Axel Sckell

Vinorelbine plus 3-weekly trastuzumab in metastatic breast cancer: a single-centre phase 2 trial

  • Open Access
  • Research article

Ermelinda De Maio, Carmen Pacilio, Adriano Gravina, Alessandro Morabito, Francesca Di Rella, Vincenzo Labonia, Gabriella Landi, Francesco Nuzzo, Emanuela Rossi, Pasqualina Silvestro, Gerardo Botti, Maurizio Di Bonito, Maria Pia Curcio, Franca Formichelli, Franca La Vecchia, Maria Staiano, Nicola Maurea, Giuseppe D'Aiuto, Massimiliano D'Aiuto, Renato Thomas, Giuseppe Signoriello, Francesco Perrone, Andrea de Matteis

Clinical benefit of readministration of gefitinib for initial gefitinib-responders with non-small cell lung cancer

  • Open Access
  • Research article

Hiroshi Yokouchi, Koichi Yamazaki, Ichiro Kinoshita, Jun Konishi, Hajime Asahina, Noriaki Sukoh, Masao Harada, Kenji Akie, Shigeaki Ogura, Takashi Ishida, Mitsuru Munakata, Hirotoshi Dosaka-Akita, Hiroshi Isobe, Masaharu Nishimura

Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-β

  • Open Access
  • Research article

O Cristina Micali, Herman H Cheung, Stéphanie Plenchette, Sandra L Hurley, Peter Liston, Eric C LaCasse, Robert G Korneluk

Whole brain radiotherapy for brain metastases from breast cancer: estimation of survival using two stratification systems

  • Open Access
  • Research article

Gustavo A Viani, Marcus S Castilho, João V Salvajoli, Antonio Cassio A Pellizzon, Paulo E Novaes, Flavio S Guimarães, Maria A Conte, Ricardo C Fogaroli

Common NOD2/CARD15 variants are not associated with susceptibility or the clinicopathologic characteristics of sporadic colorectal cancer in Hungarian patients

  • Open Access
  • Research article

Peter Laszlo Lakatos, Erika Hitre, Ferenc Szalay, Kerstin Zinober, Peter Fuszek, Laszlo Lakatos, Simon Fischer, Janos Osztovits, Orsolya Gemela, Gabor Veres, Janos Papp, Peter Ferenci

Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis

  • Open Access
  • Research article

Gulisa Turashvili, Jan Bouchal, Karl Baumforth, Wenbin Wei, Marta Dziechciarkova, Jiri Ehrmann, Jiri Klein, Eduard Fridman, Jozef Skarda, Josef Srovnal, Marian Hajduch, Paul Murray, Zdenek Kolar

Non-alcoholic beverages and risk of bladder cancer in Uruguay

  • Open Access
  • Research article

Eduardo De Stefani, Paolo Boffetta, Hugo Deneo-Pellegrini, Pelayo Correa, Alvaro L Ronco, Paul Brennan, Gilles Ferro, Giselle Acosta, María Mendilaharsu

Matrix-comparative genomic hybridization from multicenter formalin-fixed paraffin-embedded colorectal cancer tissue blocks

  • Open Access
  • Research article

Heiko Fensterer, Bernhard Radlwimmer, Jörn Sträter, Malte Buchholz, Daniela E Aust, Catherine Julié, François Radvanyi, Bernard Nordlinger, Claudio Belluco, Eric Van Cutsem, Claus-Henning Köhne, Hans A Kestler, Carsten Schwaenen, Michelle Nessling, Manfred P Lutz, Peter Lichter, Thomas M Gress

Enhanced NFκB and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer

  • Open Access
  • Research article

Yamei Zhou, Christina Yau, Joe W Gray, Karen Chew, Shanaz H Dairkee, Dan H Moore, Urs Eppenberger, Serenella Eppenberger-Castori, Christopher C Benz

Ovarian cancer risk and common variation in the sex hormone-binding globulin gene: a population-based case-control study

  • Open Access
  • Research article

Montserrat Garcia-Closas, Louise A Brinton, Jolanta Lissowska, Douglas Richesson, Mark E Sherman, Neonila Szeszenia-Dabrowska, Beata Peplonska, Robert Welch, Meredith Yeager, Witold Zatonski, Stephen J Chanock

Identification of a robust gene signature that predicts breast cancer outcome in independent data sets

  • Open Access
  • Research article

James E Korkola, Ekaterina Blaveri, Sandy DeVries, Dan H Moore II, E Shelley Hwang, Yunn-Yi Chen, Anne LH Estep, Karen L Chew, Ronald H Jensen, Frederic M Waldman

Curative and organ-preserving treatment with intra-arterial carboplatin induction followed by surgery and/or radiotherapy for advanced head and neck cancer: single-center five-year results

  • Open Access
  • Research article

Giulia Bertino, Marco Benazzo, Patrizia Gatti, Gianni Bernardo, Franco Corbella, Carmine Tinelli, Federico Zappoli, Eugenio Mira

Prognostic significance of bcl-2 expression in stage III breast cancer patients who had received doxorubicin and cyclophosphamide followed by paclitaxel as adjuvant chemotherapy

  • Open Access
  • Research article

Kyung-Hun Lee, Seock-Ah Im, Do-Youn Oh, Se-Hoon Lee, Eui Kyu Chie, Wonshik Han, Dong-Wan Kim, Tae-You Kim, In Ae Park, Dong-Young Noh, Dae Seog Heo, Sung Whan Ha, Yung-Jue Bang

Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process

  • Open Access
  • Research article

Uma R Chandran, Changqing Ma, Rajiv Dhir, Michelle Bisceglia, Maureen Lyons-Weiler, Wenjing Liang, George Michalopoulos, Michael Becich, Federico A Monzon

Cyclophosphamide "metronomic" chemotherapy for palliative treatment of a young patient with advanced epithelial ovarian cancer

  • Open Access
  • Case report

Riccardo Samaritani, Giacomo Corrado, Enrico Vizza, Carlo Sbiroli

Sequence, "subtle" alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors

  • Open Access
  • Research article

Lorenza Vitale, Flavia Frabetti, Shane A Huntsman, Silvia Canaider, Raffaella Casadei, Luca Lenzi, Federica Facchin, Paolo Carinci, Maria Zannotti, Domenico Coppola, Pierluigi Strippoli

Aberrant over-expression of a forkhead family member, FOXO1A, in a brain tumor cell line

  • Open Access
  • Research article

Peter B Dallas, Simone Egli, Philippa A Terry, Ursula R Kees

Incidence of cancer in children residing in ten jurisdictions of the Mexican Republic: importance of the Cancer registry (a population-based study)

  • Open Access
  • Research article

Arturo Fajardo-Gutiérrez, Servando Juárez-Ocaña, Guadalupe González-Miranda, Virginia Palma-Padilla, Rogelio Carreón-Cruz, Manuel Carlos Ortega-Alvárez, Juan Manuel Mejía-Arangure

Interventionally implanted port catheter systems for hepatic arterial infusion of chemotherapy in patients with colorectal liver metastases: A phase II-study and historical comparison with the surgical approach

  • Open Access
  • Research article

Bert Hildebrandt, Maciej Pech, Annett Nicolaou, Jan M Langrehr, Jacek Kurcz, Birgit Bartels, Alexandra Miersch, Roland Felix, Peter Neuhaus, Hanno Riess, Bernd Dörken, Jens Ricke

Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -251 polymorphisms in the risk for the development of distal gastric cancer

  • Open Access
  • Research article

Elvira Garza-Gonzalez, Francisco J Bosques-Padilla, Sandra I Mendoza-Ibarra, Juan P Flores-Gutierrez, Hector J Maldonado-Garza, Guillermo I Perez-Perez

Radiotherapy waiting times for women with breast cancer: a population-based cohort study

  • Open Access
  • Research article

Ruth H Jack, Elizabeth A Davies, David Robinson, Richard Sainsbury, Henrik Møller

Nectin-4 is a new histological and serological tumor associated marker for breast cancer

  • Open Access
  • Research article

Stéphanie Fabre-Lafay, Florence Monville, Sarah Garrido-Urbani, Carole Berruyer-Pouyet, Christophe Ginestier, Nicolas Reymond, Pascal Finetti, Richard Sauvan, José Adélaïde, Jeannine Geneix, Eric Lecocq, Cornel Popovici, Patrice Dubreuil, Patrice Viens, Anthony Gonçalves, Emmanuelle Charafe-Jauffret, Jocelyne Jacquemier, Daniel Birnbaum, Marc Lopez

Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers

  • Open Access
  • Research article

Yang Liu, Weimin Gao, Jill M Siegfried, Joel L Weissfeld, James D Luketich, Phouthone Keohavong

The development of an arm activity survey for breast cancer survivors using the Protection Motivation Theory

  • Open Access
  • Study protocol

Teresa S Lee, Sharon L Kilbreath, Gerard Sullivan, Kathryn M Refshauge, Jane M Beith

Colon cancer risk and different HRT formulations: a case-control study

  • Open Access
  • Research article

Jürgen C Dinger, Lothar AJ Heinemann, Sabine Möhner, Do Minh Thai, Anita Assmann

Trial on Refinement of Early stage non-small cell lung cancer. Adjuvant chemotherapy with pemetrexed and cisplatin versus vinorelbine and cisplatin: The TREAT protocol

  • Open Access
  • Study protocol

Michael Kreuter, Johan Vansteenkiste, Frank Griesinger, Hans Hoffmann, Hendrik Dienemann, Paul De Leyn, Michael Thomas

Municipal distribution of breast cancer mortality among women in Spain

  • Open Access
  • Research article

Marina Pollán, Rebeca Ramis, Nuria Aragonés, Beatriz Pérez-Gómez, Diana Gómez, Virginia Lope, Javier García-Pérez, Jose Miguel Carrasco, Maria José García-Mendizábal, Gonzalo López-Abente

Gastrointestinal stromal tumour of the duodenum in childhood: a rare case report

  • Open Access
  • Case report

Massimo Chiarugi, Christian Galatioto, Piero Lippolis, Giuseppe Zocco, Massimo Seccia

Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin™) in HER2-overexpressing breast cancer cells

  • Open Access
  • Research article

Javier A Menendez, Alejandro Vazquez-Martin, Ramon Colomer, Joan Brunet, Alegria Carrasco-Pancorbo, Rocio Garcia-Villalba, Alberto Fernandez-Gutierrez, Antonio Segura-Carretero

Sequence variations in DNA repair gene XPCis associated with lung cancer risk in a Chinese population: a case-control study

  • Open Access
  • Research article

Yun Bai, Liang Xu, Xiaobo Yang, Zhibin Hu, Jing Yuan, Feng Wang, Minhua Shao, Wentao Yuan, Ji Qian, Hongxia Ma, Ying Wang, Hongliang Liu, Weihong Chen, Lin Yang, Guangfu Jing, Xiang Huo, Feng Chen, Yanhong Liu, Li Jin, Qingyi Wei, Wei Huang, Hongbing Shen, Daru Lu, Tangchun Wu

Mesenteric extraskeletal osteosarcoma with telangiectatic features: a case report

  • Open Access
  • Case report

Kyung Hwa Lee, Jae Kyoon Joo, Dong Yi Kim, Ji Shin Lee, Chan Choi, Jae Hyuk Lee

BRIP1 (BACH1) variants and familial breast cancer risk: a case-control study

  • Open Access
  • Research article

Bernd Frank, Kari Hemminki, Alfons Meindl, Barbara Wappenschmidt, Christian Sutter, Marion Kiechle, Peter Bugert, Rita K Schmutzler, Claus R Bartram, Barbara Burwinkel

Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate

  • Open Access
  • Research article

Rikako Suzuki, Shingo Miyamoto, Yumiko Yasui, Shigeyuki Sugie, Takuji Tanaka

The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors

  • Open Access
  • Research article

Sherry L Winter, Lucine Bosnoyan-Collins, Dushanthi Pinnaduwage, Irene L Andrulis

Factors influencing delay in the diagnosis of colorectal cancer: a study protocol

  • Open Access
  • Study protocol

Magdalena Esteva, Maria Ramos, Elena Cabeza, Joan Llobera, Amador Ruiz, Salvador Pita, Josep M Segura, Jose M Cortés, Luis González-Lujan

Intratumoral delivery of IL-18 naked DNA induces T-cell activation and Th1 response in a mouse hepatic cancer model

  • Open Access
  • Research article

Chi-Young Chang, Jienny Lee, Eun-Young Kim, Hae-Jung Park, Choon-Hyuck Kwon, Jae-Won Joh, Sung-Joo Kim

Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma

  • Open Access
  • Research article

Cheng-Shyong Chang, Julia H Chang, Nicholas C Hsu, Hsuan-Yu Lin, Chih-Yuan Chung

Cross-study analysis of gene expression data for intermediate neuroblastoma identifies two biological subtypes

  • Open Access
  • Research article

Patrick Warnat, André Oberthuer, Matthias Fischer, Frank Westermann, Roland Eils, Benedikt Brors

Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate

  • Open Access
  • Research article

Bo Ye, Yu-Xia Zhang, Fei Yang, Hong-Lei Chen, Dong Xia, Ming-Qiu Liu, Bai-Tang Lai

Front-line Bevacizumab in combination with Oxaliplatin, Leucovorin and 5-Fluorouracil (FOLFOX) in patients with metastatic colorectal cancer: a multicenter phase II study

  • Open Access
  • Research article

Christos Emmanouilides, Georgia Sfakiotaki, Nikolaos Androulakis, Kostas Kalbakis, Charalambos Christophylakis, Antonia Kalykaki, Lambros Vamvakas, Athanasios Kotsakis, Sofia Agelaki, Eleni Diamandidou, Nikolaos Touroutoglou, Adam Chatzidakis, Vassilis Georgoulias, Dimitris Mavroudis, John Souglakos

"I'm pregnant and I have breast cancer"

  • Open Access
  • Commentary

Michael J Naughton, Matthew Ellis

Osteoblastic flare in a patient with advanced gastric cancer after treatment with pemetrexed and oxaliplatin: implications for response assessment with RECIST criteria

  • Open Access
  • Case report

Vito Amoroso, Frida Pittiani, Salvatore Grisanti, Francesca Valcamonico, Edda Simoncini, Vittorio D Ferrari, Giovanni Marini

A phase II trial of gemcitabine plus carboplatin in advanced transitional cell carcinoma of the urothelium

  • Open Access
  • Research article

Nong Xu, Xiao Chen Zhang, Jian Ping Xiong, Wei Jia Fang, Lan Fang Yu, Jiong Qian, Ling Zhang

Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosis

  • Open Access
  • Research article

Jane C Figueiredo, Julia A Knight, Stewart Cho, Sevtap Savas, U Venus Onay, Laurent Briollais, Pamela J Goodwin, John R McLaughlin, Irene L Andrulis, Hilmi Ozcelik

Reliability and validity of needle biopsy evaluation of breast-abnormalities using the B-categorization – design and objectives of the Diagnosis Optimisation Study (DIOS)

  • Open Access
  • Study protocol

Alexander Kluttig, Pietro Trocchi, Anke Heinig, Hans-Juergen Holzhausen, Christiane Taege, Steffen Hauptmann, Werner Boecker, Thomas Decker, Thomas Loening, Andrea Schmidt-Pokrzywniak, Christoph Thomssen, Tilmann Lantzsch, Joerg Buchmann, Andreas Stang

Prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan

  • Open Access
  • Research article

Ping-Ho Chen, Tien-Yu Shieh, Pei-Shan Ho, Chi-Cheng Tsai, Yi-Hsin Yang, Ying-Chu Lin, Min-Shan Ko, Pei-Chien Tsai, Shang-Lun Chiang, Hung-Pin Tu, Ying-Chin Ko

Factors associated with quality of life of outpatients with breast cancer and gynecologic cancers and their family caregivers: a controlled study

  • Open Access
  • Research article

Abdel W Awadalla, Jude U Ohaeri, Abdullah Gholoum, Ahmed OA Khalid, Hussein MA Hamad, Anila Jacob

Small primary adenocarcinoma in adenomyosis with nodal metastasis: a case report

  • Open Access
  • Case report

Giacomo Puppa, Makio Shozu, Tiziana Perin, Kazuhito Nomura, Annunziata Gloghini, Elio Campagnutta, Vincenzo Canzonieri

Reduction of peritoneal carcinomatosis by intraperitoneal administration of phospholipids in rats

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Jens Otto, Petra Lynen Jansen, Stefan Lucas, Volker Schumpelick, Marc Jansen

Elevated expression of VEGFR-3 in lymphatic endothelial cells from lymphangiomas

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Susanne Norgall, Maria Papoutsi, Jochen Rössler, Lothar Schweigerer, Jörg Wilting, Herbert A Weich

Endostatin gene variation and protein levels in breast cancer susceptibility and severity

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Sabapathy P Balasubramanian, Simon S Cross, Jenny Globe, Angela Cox, Nicola J Brown, Malcolm W Reed

Repression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but not its receptors during oral cancer progression

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Nadarajah Vigneswaran, Darryl C Baucum, Jean Wu, Yahuan Lou, Jerry Bouquot, Susan Muller, Wolfgang Zacharias

Pathway aberrations of murine melanoma cells observed in Paired-End diTag transcriptomes

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Kuo Ping Chiu, Pramila Ariyaratne, Han Xu, Adrian Tan, Patrick Ng, Edison Tak-Bun Liu, Yijun Ruan, Chia-Lin Wei, Wing-Kin Ken Sung

External influences and priority-setting for anti-cancer agents: a case study of media coverage in adjuvant trastuzumab for breast cancer

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Christopher M Booth, George Dranitsaris, M Corona Gainford, Scott Berry, Michael Fralick, John Fralick, Joanna Sue, Mark Clemons

Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells

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Chun-Liang Chen, Abbey Loy, Ling Cen, Christina Chan, Fu-Chuan Hsieh, Gong Cheng, Bryant Wu, Stephen J Qualman, Keita Kunisada, Keiko Yamauchi-Takihara, Jiayuh Lin

Sequential (gemcitabine/vinorelbine) and concurrent (gemcitabine) radiochemotherapy with FDG-PET-based target volume definition in locally advanced non-small cell lung cancer: first results of a phase I/II study

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Bernd Gagel, Marc Piroth, Michael Pinkawa, Patrick Reinartz, Thomas Krohn, Hans J Kaiser, Sven Stanzel, Christian Breuer, Branka Asadpour, Axel Schmachtenberg, Michael J Eble

pO polarography, contrast enhanced color duplex sonography (CDS), [18F] fluoromisonidazole and [18F] fluorodeoxyglucose positron emission tomography: validated methods for the evaluation of therapy-relevant tumor oxygenation or only bricks in the puzzle of tumor hypoxia?

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Bernd Gagel, Marc Piroth, Michael Pinkawa, Patrick Reinartz, Michael Zimny, Hans J Kaiser, Sven Stanzel, Branka Asadpour, Cengiz Demirel, Kurt Hamacher, Heinz H Coenen, Thomas Scholbach, Payam Maneschi, Ercole DiMartino, Michael J Eble

Developments in esophageal surgery for adenocarcinoma: a comparison of two decades

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I Gockel, FS Sultanov, M Domeyer, U Goenner, Th Junginger

Case-only study of interactions between metabolic enzymes and smoking in colorectal cancer

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Chunhong Fan, Mingjuan Jin, Kun Chen, Yongjing Zhang, Shuangshuang Zhang, Bing Liu

Pseudomyxoma peritonei – two novel orthotopic mouse models portray the PMCA-I histopathologic subtype

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Kjersti Flatmark, Wenche Reed, Thomas Halvorsen, Olaf Sørensen, Johan N Wiig, Stein G Larsen, Øystein Fodstad, Karl-Erik Giercksky

Introduction of a breast cancer care programme including ultra short hospital stay in 4 early adopter centres: framework for an implementation study

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  • Study protocol

Mascha de Kok, Caroline NA Frotscher, Trudy van der Weijden, Alfons GH Kessels, Carmen D Dirksen, Cornelis JH van de Velde, Jan A Roukema, Antoine VRJ Bell, Fred W van der Ent, Maarten F von Meyenfeldt

Genetic variability in CYP3A4 and CYP3A5in primary liver, gastric and colorectal cancer patients

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Guillermo Gervasini, Elena García-Martín, José M Ladero, Rosa Pizarro, Javier Sastre, Carmen Martínez, Monserrat García, Manuel Diaz-Rubio, José AG Agúndez

A full scale comparative study of methods for generation of functional Dendritic cells for use as cancer vaccines

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Silvija Jarnjak-Jankovic, Hege Hammerstad, Stein Sæbøe-Larssen, Gunnar Kvalheim, Gustav Gaudernack

Association of diminished expression of RASSF1A with promoter methylation in primary gastric cancer from patients of central China

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Mei Ye, Bing Xia, Qiusha Guo, Feng Zhou, Xiaolian Zhang

Synergistic activity of troxacitabine (Troxatyl™) and gemcitabine in pancreatic cancer

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Vijaya L Damaraju, David Y Bouffard, Clarence KW Wong, Marilyn L Clarke, John R Mackey, Lorraine Leblond, Carol E Cass, Mike Grey, Henriette Gourdeau

Particular distribution and expression pattern of endoglin (CD105) in the liver of patients with hepatocellular carcinoma

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Decai Yu, Linyuan Zhuang, Xitai Sun, Jun Chen, Yongzhong Yao, Kui Meng, Yitao Ding

Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1and colorectal cancer risk

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Lara Bethke, Emily Webb, Gabrielle Sellick, Matthew Rudd, Stephen Penegar, Laura Withey, Mobshra Qureshi, Richard Houlston

Sialyl Lewis x expression in canine malignant mammary tumours: correlation with clinicopathological features and E-Cadherin expression

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Salomé S Pinho, Augusto JF Matos, Célia Lopes, Nuno T Marcos, Júlio Carvalheira, Celso A Reis, Fátima Gärtner

The synergistic inhibitory effect of somatostatin-doxorubicin co-treatment on gallbladder carcinoma

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Ji-Yu Li, Zhi-Wei Quan, Qiang Zhang, Jian-Wen Liu

Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma

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Jian Huang, Yun-Li Zhang, Xiao-Mei Teng, Yun Lin, Da-Li Zheng, Peng-Yuan Yang, Ze-Guang Han

Overexpressed TP73 induces apoptosis in medulloblastoma

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Robert C Castellino, Massimiliano De Bortoli, Linda L Lin, Darlene G Skapura, Jessen A Rajan, Adekunle M Adesina, Laszlo Perlaky, Meredith S Irwin, John YH Kim

Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients

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Trevor J Pugh, Gwyn Bebb, Lorena Barclay, Margaret Sutcliffe, John Fee, Chris Salski, Robert O'Connor, Cheryl Ho, Nevin Murray, Barbara Melosky, John English, Jeurgen Vielkind, Doug Horsman, Janessa J Laskin, Marco A Marra

Satisfaction with care among patients with non-metastatic breast cancer: development and first steps of validation of the REPERES-60 questionnaire

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Gautier Defossez, Simone Mathoulin-Pelissier, Isabelle Ingrand, Isabelle Gasquet, Lynda Sifer-Riviere, Pierre Ingrand, Roger Salamon, Virginie Migeot

Promotion of breast cancer by β-Hexachlorocyclohexane in MCF10AT1 cells and MMTV-neu mice

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Patrick S Wong, Fumio Matsumura

Association of oestrogen receptor beta 2 (ERβ2/ERβcx) with outcome of adjuvant endocrine treatment for primary breast cancer – a retrospective study

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Raman Vinayagam, D Ross Sibson, Christopher Holcombe, Vijay Aachi, Michael PA Davies

Origin and distribution of the BRCA2-8765delAG mutation in breast cancer

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Grazia Palomba, Antonio Cossu, Eitan Friedman, Mario Budroni, Antonio Farris, Antonio Contu, Marina Pisano, Paola Baldinu, Maria C Sini, Francesco Tanda, Giuseppe Palmieri

Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors

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Vera L Costa, Rui Henrique, Franclim R Ribeiro, Mafalda Pinto, Jorge Oliveira, Francisco Lobo, Manuel R Teixeira, Carmen Jerónimo

Use of immunohistochemical markers can refine prognosis in triple negative breast cancer

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Marc Tischkowitz, Jean-Sébastien Brunet, Louis R Bégin, David G Huntsman, Maggie CU Cheang, Lars A Akslen, Torsten O Nielsen, William D Foulkes

Null mutation for Macrophage Migration Inhibitory Factor (MIF) is associated with less aggressive bladder cancer in mice

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John A Taylor III, George A Kuchel, Poornima Hegde, Olga S Voznesensky, Kevin Claffey, John Tsimikas, Lin Leng, Richard Bucala, Carol Pilbeam

Favorable prognostic value of SOCS2 and IGF-I in breast cancer

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Michael C Haffner, Barbara Petridou, Jean Phillipe Peyrat, Françoise Révillion, Elisabeth Müller-Holzner, Günter Daxenbichler, Christian Marth, Wolfgang Doppler

PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer

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Katherine AB Knostman, James A McCubrey, Carl D Morrison, Zhaoxia Zhang, Charles C Capen, Sissy M Jhiang

Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism

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Rasha Hammamieh, Dena Sumaida, XiaoYan Zhang, Rina Das, Marti Jett

HIF2α reduces growth rate but promotes angiogenesis in a mouse model of neuroblastoma

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Judith Favier, Stéphanie Lapointe, Ricardo Maliba, Martin G Sirois

Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells

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Mikio Terauchi, Hiroaki Kajiyama, Kiyosumi Shibata, Kazuhiko Ino, Akihiro Nawa, Shigehiko Mizutani, Fumitaka Kikkawa

Metabolic profiling of human brain metastases using in vivo proton MR spectroscopy at 3T

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Torill E Sjøbakk, Roar Johansen, Tone F Bathen, Ursula Sonnewald, Kjell A Kvistad, Steinar Lundgren, Ingrid S Gribbestad

A phase II trial of docetaxel and erlotinib as first-line therapy for elderly patients with androgen-independent prostate cancer

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Mitchell Gross, Celestia Higano, Allan Pantuck, Olga Castellanos, Erica Green, Koo Nguyen, David B Agus

Induction of plasminogen activator inhibitor type-1 (PAI-1) by hypoxia and irradiation in human head and neck carcinoma cell lines

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Daniela Schilling, Christine Bayer, Anneke Geurts-Moespot, Fred CGJ Sweep, Martin Pruschy, Karin Mengele, Lisa D Sprague, Michael Molls

Synoptic tool for reporting of hematological and lymphoid neoplasms based on World Health Organization classification and College of American Pathologists checklist

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Sambit K Mohanty, Anthony L Piccoli, Lisa J Devine, Ashokkumar A Patel, Gross C William, Sharon B Winters, Michael J Becich, Anil V Parwani

Critical role of c-Jun overexpression in liver metastasis of human breast cancer xenograft model

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Yan Zhang, Xiaoyun Pu, Ming Shi, Liyong Chen, Yuhua Song, Lu Qian, Guogang Yuan, Hao Zhang, Ming Yu, Meiru Hu, Beifen Shen, Ning Guo

Functional overload attenuates plantaris atrophy in tumor-bearing rats

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Jeffrey S Otis, Simon J Lees, Jay H Williams

Case report: PET/CT, a cautionary tale

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  • Case report

Jayson Wang, Gary Cook, John Frank, Roberto Dina, Naomi Livni, John Lynn, William Fleming, Michael J Seckl

Host-derived RANKL is responsible for osteolysis in a C4-2 human prostate cancer xenograft model of experimental bone metastases

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Colm Morrissey, Paul L Kostenuik, Lisha G Brown, Robert L Vessella, Eva Corey

Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice

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Xulong Zhang, Jian Zhang, Lihua Wang, Haiming Wei, Zhigang Tian

Fatal interstitial lung disease associated with oral erlotinib therapy for lung cancer

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Demosthenes Makris, Arnaud Scherpereel, Marie Christine Copin, Guillaume Colin, Luc Brun, Jean Jacques Lafitte, Charles Hugo Marquette

Paradoxes in carcinogenesis: New opportunities for research directions

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  • Debate

Stuart G Baker, Barnett S Kramer

Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials

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Gustavo A Viani, Sergio L Afonso, Eduardo J Stefano, Ligia I De Fendi, Francisco V Soares

Gastrointestinal permeability in ovarian cancer and breast cancer patients treated with paclitaxel and platinum

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Bohuslav Melichar, Radomír Hyšpler, Emanuela Dragounová, Josef Dvořák, Hana Kalábová, Alena Tichá

Influence of IFN-gamma and its receptors in human breast cancer

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Ignacio García-Tuñón, Mónica Ricote, Antonio Ruiz A, Benito Fraile, Ricardo Paniagua, Mar Royuela

Increased interferon alpha receptor 2 mRNA levels is associated with renal cell carcinoma metastasis

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Takao Kamai, Yoshiaki Yanai, Kyoko Arai, Hideyuki Abe, Tomonori Yamanishi, Masashi Kurimoto, Ken-Ichiro Yoshida

Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH): study protocol

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  • Study protocol

Diana Eccles, Sue Gerty, Peter Simmonds, Victoria Hammond, Sarah Ennis, Douglas G Altman

Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein

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Padideh Davoodpour, Maréne Landström, Michael Welsh

Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of Northern Spain

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M Felicitas López-Cima, Patricia González-Arriaga, Laura García-Castro, Teresa Pascual, Manuel G Marrón, Xose S Puente, Adonina Tardón

CHEK2 1100delC is prevalent in Swedish early onset familial breast cancer

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Sara Margolin, Hans Eiberg, Annika Lindblom, Marie Luise Bisgaard

Prognostic value of histopathology and trends in cervical cancer: a SEER population study

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Vincent Vinh-Hung, Claire Bourgain, Georges Vlastos, Gábor Cserni, Mark De Ridder, Guy Storme, Anne-Thérèse Vlastos

Mast cells and eosinophils in invasive breast carcinoma

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Rose-Marie Amini, Kirsimari Aaltonen, Heli Nevanlinna, Ricardo Carvalho, Laura Salonen, Päivi Heikkilä, Carl Blomqvist

The efficacy of physiotherapy upon shoulder function following axillary dissection in breast cancer, a randomized controlled study

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Carien HG Beurskens, Caro JT van Uden, Luc JA Strobbe, Rob AB Oostendorp, Theo Wobbes

Radiotherapeutic alternatives for previously irradiated recurrent gliomas

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Stephanie E Combs, Jürgen Debus, Daniela Schulz-Ertner

High resolution melting for mutation scanning of TP53exons 5–8

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Michael Krypuy, Ahmed Ashour Ahmed, Dariush Etemadmoghadam, Sarah J Hyland, Anna deFazio, Stephen B Fox, James D Brenton, David D Bowtell, Alexander Dobrovic

Over-expression of 14-3-3zeta is an early event in oral cancer

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Ajay Matta, Sudhir Bahadur, Ritu Duggal, Siddhartha D Gupta, Ranju Ralhan

Association between the BRCA2N372H variant and male breast cancer risk: a population-based case-control study in Tuscany, Central Italy

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Domenico Palli, Mario Falchetti, Giovanna Masala, Ramona Lupi, Francesco Sera, Calogero Saieva, Cristina D'Amico, Marco Ceroti, Piera Rizzolo, Maria Adelaide Caligo, Ines Zanna, Laura Ottini

Real time contrast enhanced ultrasonography in detection of liver metastases from gastrointestinal cancer

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Fabio Piscaglia, Francesco Corradi, Mikaela Mancini, Francesco Giangregorio, Stefano Tamberi, Giampaolo Ugolini, Bruno Cola, Alberto Bazzocchi, Roberto Righini, Patrizia Pini, Fabio Fornari, Luigi Bolondi

Identification of MSRA gene on chromosome 8p as a candidate metastasis suppressor for human hepatitis B virus-positive hepatocellular carcinoma

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Ke-Feng Lei, Yan-Fang Wang, Xiao-Qun Zhu, Peng-Cheng Lu, Bing-Sheng Sun, Hu-Liang Jia, Ning Ren, Qing-Hai Ye, Hui-Chuan Sun, Lu Wang, Zhao-You Tang, Lun-Xiu Qin

Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population

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Lihong Wang, Dalin Li, Zhenkun Fu, Heng Li, Wei Jiang, Dianjun Li

Ductal carcinoma in situ of the breast (DCIS) with heterogeneity of nuclear grade: prognostic effects of quantitative nuclear assessment

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Judith-Anne W Chapman, Naomi A Miller, H Lavina A Lickley, Jin Qian, William A Christens-Barry, Yuejiao Fu, Yan Yuan, David E Axelrod

TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study

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David G Cox, Kathryn Penney, Qun Guo, Susan E Hankinson, David J Hunter

Differential regulation of iron chelator-induced IL-8 synthesis via MAP kinase and NF-κB in immortalized and malignant oral keratinocytes

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Hwa-Jeong Lee, Jun Lee, Sun-Kyung Lee, Suk-Keun Lee, Eun-Cheol Kim

Intensity Modulated Radiotherapy (IMRT) and Fractionated Stereotactic Radiotherapy (FSRT) for children with head-and-neck-rhabdomyosarcoma

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Stephanie E Combs, Wolfgang Behnisch, Andreas E Kulozik, Peter E Huber, Jürgen Debus, Daniela Schulz-Ertner

Intraoperative radiotherapy (IORT) is an option for patients with localized breast recurrences after previous external-beam radiotherapy

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Uta Kraus-Tiefenbacher, Lelia Bauer, Antonella Scheda, Carola Schoeber, Joerg Schaefer, Volker Steil, Frederik Wenz

Proto-oncogene HER-2 in normal, dysplastic and tumorous feline mammary glands: an immunohistochemical and chromogenic in situ hybridization study

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Javier Ordás, Yolanda Millán, Rafaela Dios, Carlos Reymundo, Juana Martín de las Mulas

A mouse model for Luminal epithelial like ER positive subtype of human breast cancer

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MJ Mahesh Kumar, KS Ponvijay, R Nandhini, RS Nagarajan, J Jose, G Srinivas, P Nagarajan, R Venkatesan, Kishor Kumar, S Singh

Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer

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Jack X Yu, Anieta M Sieuwerts, Yi Zhang, John WM Martens, Marcel Smid, Jan GM Klijn, Yixin Wang, John A Foekens

The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase

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Janet V Cross, Frank W Foss, Joshua M Rady, Timothy L Macdonald, Dennis J Templeton

Paradoxical antiproliferative effect by a murine mammary tumor-derived epithelial cell line

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Esteban N Gurzov, Sanaa M Nabha, Hamilto Yamamoto, Hong Meng, O Graciela Scharovsky, R Daniel Bonfil

Assessment of free light chains in the cerebrospinal fluid of patients with lymphomatous meningitis – a pilot study

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B Hildebrandt, C Müller, A Pezzutto, PT Daniel, B Dörken, C Scholz

Across-province standardization and comparative analysis of time-to-care intervals for cancer

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Marcy Winget, Donna Turner, Jon Tonita, Charlotte King, Zoann Nugent, Riaz Alvi, Richard Barss

The 2G allele of promoter region of Matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma

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Rishiho Nishizawa, Masaki Nagata, Arhab A Noman, Nobutaka Kitamura, Hajime Fujita, Hideyuki Hoshina, Takehiko Kubota, Manami Itagaki, Susumu Shingaki, Makoto Ohnishi, Hiroshi Kurita, Kouji Katsura, Chikara Saito, Hiromasa Yoshie, Ritsuo Takagi

The radiosensitizing effect of doranidazole on human colorectal cancer cells exposed to high doses of irradiation

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Li Zhang, Aimin Gong, Jun Ji, Yuanyuan Wu, Xiaoyu Zhu, Suqing Lv, Hongzhu Lv, Xizhuo Sun

Clonal mutations in primary human glial tumors: evidence in support of the mutator hypothesis

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Anjan Misra, Parthaprasad Chattopadhyay, Kunzang Chosdol, Chitra Sarkar, Ashok K Mahapatra, Subrata Sinha

Proteome analysis of human gastric cardia adenocarcinoma by laser capture microdissection

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Yan Cheng, Jun Zhang, Yang Li, Yan Wang, Jun Gong

Expression of NDRG2 is down-regulated in high-risk adenomas and colorectal carcinoma

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Anders Lorentzen, Lotte K Vogel, Rikke H Lewinsky, Mona Sæbø, Camilla F Skjelbred, Sine Godiksen, Geir Hoff, Kjell M Tveit, Inger Marie Bowitz Lothe, Tone Ikdahl, Elin H Kure, Cathy Mitchelmore

Longitudinal, population-based study of racial/ethnic differences in colorectal cancer survival: impact of neighborhood socioeconomic status, treatment and comorbidity

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Scarlett Lin Gomez, Cynthia D O'Malley, Antoinette Stroup, Sarah J Shema, William A Satariano

Genetic polymorphisms of TLR3 are associated with Nasopharyngeal carcinoma risk in Cantonese population

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Jun-Fang He, Wei-Hua Jia, Qin Fan, Xin-Xi Zhou, Hai-De Qin, Yin Yao Shugart, Yi-Xin Zeng

Bcl11bmutations identified in murine lymphomas increase the proliferation rate of hematopoietic progenitor cells

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Anneli Karlsson, Amanda Nordigården, Jan-Ingvar Jönsson, Peter Söderkvist

Changes in the distribution pattern of Claudin tight junction proteins during the progression of mouse skin tumorigenesis

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Azadeh Arabzadeh, Tammy-Claire Troy, Kursad Turksen

Nuclear localization and cytosolic overexpression of LASP-1 correlates with tumor size and nodal-positivity of human breast carcinoma

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Thomas GP Grunewald, Ulrike Kammerer, Michaela Kapp, Matthias Eck, Johannes Dietl, Elke Butt, Arnd Honig

Polymorphisms in the epidermal growth factor receptor gene and the risk of primary lung cancer: a case-control study

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Jin Eun Choi, Sun Ha Park, Kyung Mee Kim, Won Kee Lee, Sin Kam, Sung Ick Cha, Chang Ho Kim, Young Mo Kang, Young-Chul Kim, Sung Beom Han, Tae Hoon Jung, Jae Yong Park

Clinical implications of metastatic lymph node ratio in gastric cancer

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Caigang Liu, Ping Lu, Yang Lu, Huimian Xu, Shubao Wang, Junqing Chen

Disparities in mammographic screening for Asian women in California: a cross-sectional analysis to identify meaningful groups for targeted intervention

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Scarlett Lin Gomez, Susanna Tan, Theresa HM Keegan, Christina A Clarke

Neurotrophin receptors expression and JNK pathway activation in human astrocytomas

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Martha Assimakopoulou, Maria Kondyli, George Gatzounis, Theodore Maraziotis, John Varakis

Prognostic impact of clinicopathologic parameters in stage II/III breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: paradoxical features of the triple negative breast cancer

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Bhumsuk Keam, Seock-Ah Im, Hee-Jun Kim, Do-Youn Oh, Jee Hyun Kim, Se-Hoon Lee, Eui Kyu Chie, Wonshik Han, Dong-Wan Kim, Woo Kyung Moon, Tae-You Kim, In Ae Park, Dong-Young Noh, Dae Seog Heo, Sung Whan Ha, Yung-Jue Bang

Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins

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Marcia R Saban, Helen L Hellmich, Cindy Simpson, Carole A Davis, Mark L Lang, Michael A Ihnat, Michael A O'Donnell, Xue-Ru Wu, Ricardo Saban

S100A7 (Psoriasin), highly expressed in Ductal Carcinoma In Situ(DCIS), is regulated by IFN-gamma in mammary epithelial cells

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Stina Petersson, Anna Bylander, Maria Yhr, Charlotta Enerbäck

Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population

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Stefania Boccia, Fakhredin A Sayed-Tabatabaei, Roberto Persiani, Francesco Gianfagna, Stefano Rausei, Dario Arzani, Antonio La Greca, Domenico D'Ugo, Giuseppe La Torre, Cornelia M van Duijn, Gualtiero Ricciardi

RETRACTED ARTICLE: PYRROLO[1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) induce apoptosis in K562 cells

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Gabriella Marfe, Carla Di Stefano, Romano Silvestri, Elisabetta Abruzzese, Gianfranco Catalano, Livia Di Renzo, Giuseppe Filomeni, Ezio Giorda, Giuseppe La Regina, Emanuela Morgante, Maria Rosa Ciriolo, Matteo Antonio Russo, Sergio Amadori, Paola Sinibaldi-Salimei

Coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma Cells

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Xinxin Bu, Fengqi Jia, Weifeng Wang, Xianling Guo, Mengchao Wu, Lixin Wei

High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition

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Susanne Klein-Scory, Marc Zapatka, Christina Eilert-Micus, Sabine Hoppe, Elisabeth Schwarz, Wolff Schmiegel, Stephan A Hahn, Irmgard Schwarte-Waldhoff

Physical activity in Hodgkin's lymphoma survivors with and without chronic fatigue compared with the general population – a cross-sectional study

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Line M Oldervoll, Jon H Loge, Stein Kaasa, Stian Lydersen, Marianne J Hjermstad, Lene Thorsen, Harald Holte Jr, Anne B Jacobsen, Sophie D Fosså

BMP-6 promotes E-cadherin expression through repressing δEF1 in breast cancer cells

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Shuang Yang, Jun Du, Zhaoqi Wang, Wei Yuan, Yuhuan Qiao, Ming Zhang, Jie Zhang, Songyuan Gao, Jian Yin, Baocun Sun, Tianhui Zhu

Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

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Laura Lentini, Angela Amato, Tiziana Schillaci, Aldo Di Leonardo

Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells

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  • Research article

Adrian Staab, Jürgen Loeffler, Harun M Said, Désirée Diehlmann, Astrid Katzer, Melanie Beyer, Markus Fleischer, Franz Schwab, Kurt Baier, Hermann Einsele, Michael Flentje, Dirk Vordermark

UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?

  • Open Access
  • Research article

I Stücker, MA Loriot, G N'Koutchou, S Cénée, L Bodin, C Mulot, M Gelu-Simeon, L Pelletier, JP Bronowicki, F Degos, P Beaune, P Laurent-Puig, D Hémon, JC Trinchet, G Pelletier

Deficiency of G1 regulators P53, P21Cip1and/or pRb decreases hepatocyte sensitivity to TGFβ cell cycle arrest

  • Open Access
  • Research article

Sharon Sheahan, Christopher O Bellamy, Donald R Dunbar, David J Harrison, Sandrine Prost

Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line

  • Open Access
  • Research article

Yuh-Cheng Yang, Tsung-Chuan Ho, Show-Li Chen, Huei-Yi Lai, Ju-Yun Wu, Yeou-Ping Tsao

Aberrant overexpression of an epithelial marker, 14-3-3σ, in a subset of hematological malignancies

  • Open Access
  • Research article

Toru Motokura, Yukari Nakamura, Hiroyuki Sato

A comparative study between mixed-type tumours from human salivary and canine mammary glands

  • Open Access
  • Research article

Marisa CLS Genelhu, Sérgio V Cardoso, Helenice Gobbi, Geovanni D Cassali

Lymphatic vessel density and function in experimental bladder cancer

  • Open Access
  • Research article

Marcia R Saban, Rheal Towner, Nataliya Smith, Andrew Abbott, Michal Neeman, Carole A Davis, Cindy Simpson, Julie Maier, Sylvie Mémet, Xue-Ru Wu, Ricardo Saban

Epigenetic regulation of RhoB loss of expression in lung cancer

  • Open Access
  • Research article

Julien Mazières, Daniel Tovar, Biao He, Jacobo Nieto-Acosta, Claire Marty-Detraves, Carine Clanet, Anne Pradines, David Jablons, Gilles Favre

Bortezomib in combination with celecoxib in patients with advanced solid tumors: a phase I trial

  • Open Access
  • Research article

John Hayslip, Uzair Chaudhary, Mark Green, Mario Meyer, Steven Dunder, Carol Sherman, Shanta Salzer, Andrew Kraft, Alberto J Montero

Being 40 or younger is an independent risk factor for relapse in operable breast cancer patients: The Saudi Arabia experience

  • Open Access
  • Research article

Naser Elkum, Said Dermime, Dahish Ajarim, Ali Al-Zahrani, Adher Alsayed, Asma Tulbah, Osama Al Malik, Mohamed Alshabanah, Adnan Ezzat, Taher Al-Tweigeri

Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer

  • Open Access
  • Research article

Cathy B Wilcox, Grace O Feddes, Joan E Willett-Brozick, Lih-Ching Hsu, Julie A DeLoia, Bora E Baysal

Platelet-derived growth factor receptor-β, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma

  • Open Access
  • Research article

Shioto Suzuki, Carl-Henrik Heldin, Rainer Lothar Heuchel

Biological characterization of two xenografts derived from human CUPs (carcinomas of unknown primary)

  • Open Access
  • Research article

Delphine Lequin, Karim Fizazi, Saloua Toujani, Sylvie Souquère, Marie-Christine Mathieu, Pierre Hainaut, Alain Bernheim, Françoise Praz, Pierre Busson

Adjuvant whole abdominal intensity modulated radiotherapy (IMRT) for high risk stage FIGO III patients with ovarian cancer (OVAR-IMRT-01) – Pilot trial of a phase I/II study: study protocol

  • Open Access
  • Study protocol

Nathalie Rochet, Alexandra D Jensen, Florian Sterzing, Marc W Munter, Michael H Eichbaum, Andreas Schneeweiss, Christof Sohn, Juergen Debus, Wolfgang Harms

Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas

  • Open Access
  • Research article

Camilla F Skjelbred, Mona Sæbø, Anette Hjartåker, Tom Grotmol, Inger-Lise Hansteen, Kjell M Tveit, Geir Hoff, Elin H Kure

The enhanced expression of the matrix metalloproteinase 9 in nasal NK/T-cell lymphoma

  • Open Access
  • Research article

Koh-ichi Sakata, Masanori Someya, Mutsuko Omatsu, Hiroko Asanuma, Tadashi Hasegawa, Masato Hareyama, Tetsuo Himi

Incidence and clinicopathologic features of gastrointestinal stromal tumors. A population-based study

  • Open Access
  • Research article

Claudia Mucciarini, Giulio Rossi, Federica Bertolini, Riccardo Valli, Claudia Cirilli, Ivan Rashid, Luigi Marcheselli, Gabriele Luppi, Massimo Federico

Phase I dose escalation study of vinorelbine and topotecan combination chemotherapy in patients with recurrent lung cancer

  • Open Access
  • Research article

Matthew A Beldner, Carol A Sherman, Mark R Green, Elizabeth Garrett-Mayer, Uzair Chaudhary, Mario L Meyer, Andrew S Kraft, Alberto J Montero

The expression of HSP27 is associated with poor clinical outcome in intrahepatic cholangiocarcinoma

  • Open Access
  • Research article

Antonello A Romani, Pellegrino Crafa, Silvia Desenzani, Gallia Graiani, Costanza Lagrasta, Mario Sianesi, Paolo Soliani, Angelo F Borghetti

Correlation between the progressive cytoplasmic expression of a novel small heat shock protein (Hsp16.2) and malignancy in brain tumors

  • Open Access
  • Research article

Eva Pozsgai, Eva Gomori, Andras Szigeti, Arpad Boronkai, Ferenc Gallyas Jr, Balazs Sumegi, Szabolcs Bellyei

The value of prognostic factors for uterine cervical cancer patients treated with irradiation alone

  • Open Access
  • Research article

Rūta Grigienė, Konstantinas P Valuckas, Eduardas Aleknavičius, Juozas Kurtinaitis, Simona R Letautienė

Serum diagnosis of diffuse large B-cell lymphomas and further identification of response to therapy using SELDI-TOF-MS and tree analysis patterning

  • Open Access
  • Research article

Xing Zhang, Bo Wang, Xiao-shi Zhang, Zhi-ming Li, Zhong-zhen Guan, Wen-qi Jiang

Antitumor activity and mechanisms of action of total glycosides from aerial part of Cimicifuga dahurica targeted against hepatoma

  • Open Access
  • Research article

Ze Tian, Jianyong Si, Qi Chang, Liang Zhou, Shilin Chen, Peigen Xiao, Erxi Wu

Neu im Fachgebiet Onkologie

Adnexläsion zufällig im CT entdeckt? Die Befundung fällt selbst Fachleuten schwer!

Ist eine Läsion benigne oder maligne? Und um welche Art handelt es sich genau? Ergebnisse einer kleinen US-Studie zu inzidentellen CT-Befunden sprechen dafür, dass sich auch Expertinnen und Experten bei Adnex-Auffälligkeiten häufig uneins sind – und einige maligne Läsionen verkennen.

Real-World Daten bestätigen Nivolumab bei Kopf-Hals-Tumoren

In der nicht-interventionellen Real-World-Studie HANNA wurde Nivolumab bei Menschen mit rezidiviertem oder metastasiertem Plattenepithelkarzinom der Kopf-Hals-Region in verschiedenen Therapielinien geprüft. Ein Kollege präsentierte auf dem diesjährigen Krebskongress in Berlin die finalen Daten.

Wie Mikrobiom und Komedikation Immuntherapien beeinflussen

Die Effektivität von Checkpoint-Inhibitoren wird unter anderem durch das Mikrobiom und Komedikationen beeinflusst. Wie Ballaststoffe wirken und welche Medikamente man nicht zusammen mit der Immuntherapie geben sollte, zeigten eine Kollegin und ein Kollege auf dem DKK in Berlin auf.

Mehr molekulare Diagnostik bei Krebs ist nicht immer besser

Neue molekularpathologische Methoden erhöhen die diagnostische Sensitivität bei Tumorerkrankungen. Aber verfeinert ein stetiges Mehr an molekularer Diagnostik auch die therapeutische Präzision? Diese Frage wurde im Rahmen des Deutschen Krebskongresses (DKK) 2026 in Berlin diskutiert. 

Update Onkologie

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Bildnachweise
Radiologie-Assistent bereitet Frau für CT vor/© Peakstock/stock.adobe.com (Symbolbild mit Fotomodellen), Plattenepithelkarzinom/© Springer Medizin Verlag GmbH, Frau bereitet Müsli auf Waage zu/© DragonImages / Stock.adobe.com (Symbolbild mit Fotomodell), 3D Illustration einer DNA Sequenzierung/© undefined / Getty Images / iStock