BMC Cancer

Inhalt (465 Artikel)

Is overexpression of HER-2 a predictor of prognosis in colorectal cancer?

Open Access
Research article

Dara O Kavanagh, Gillian Chambers, Liam O' Grady, Kevin M Barry, Ronan P Waldron, Fadel Bennani, Paul W Eustace, Iqdam Tobbia

Morbidity associated with "self-rated health" in epithelial ovarian cancer survivors

Open Access
Research article

Astrid Helene Liavaag, Anne Dørum, Sophie D Fosså, Claes Tropé, Alv A Dahl

Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells

Open Access
Research article

Suman Verma, Michelle M Tabb, Bruce Blumberg

HER-2/neu amplification testing in breast cancer by Multiplex Ligation-dependent Probe Amplification: influence of manual- and laser microdissection

Open Access
Research article

Cathy B Moelans, Roel A de Weger, Chantal Ezendam, Paul J van Diest

Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors

Open Access
Research article

Kunzang Chosdol, Anjan Misra, Sachin Puri, Tapasya Srivastava, Parthaprasad Chattopadhyay, Chitra Sarkar, Ashok K Mahapatra, Subrata Sinha

Evaluation of gene amplification and protein expression of HER-2/neu in esophageal squamous cell carcinoma using Fluorescence in situ Hybridization (FISH) and immunohistochemistry

Open Access
Research article

Yukie Sato-Kuwabara, José I Neves, José HTG Fregnani, Rubens A Sallum, Fernando A Soares

Hypothesis: primary antiangiogenic method proposed to treat early stage breast cancer

Open Access
Hypothesis

Michael W Retsky, William JM Hrushesky, Isaac D Gukas

YKL-40 tissue expression and plasma levels in patients with ovarian cancer

Open Access
Research article

Estrid VS Høgdall, Merete Ringsholt, Claus K Høgdall, Ib Jarle Christensen, Julia S Johansen, Susanne K Kjaer, Jan Blaakaer, Lene Ostenfeld-Møller, Paul A Price, Lise H Christensen

Self-renewal and chemotherapy resistance of p75NTR positive cells in esophageal squamous cell carcinomas

Open Access
Research article

Sheng-Dong Huang, Yang Yuan, Xiao-Hong Liu, De-Jun Gong, Chen-Guang Bai, Feng Wang, Jun-Hui Luo, Zhi-Yun Xu

RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells

Open Access
Research article

André O von Bueren, Tarek Shalaby, Christoph Oehler-Jänne, Lucia Arnold, Duncan Stearns, Charles G Eberhart, Alexandre Arcaro, Martin Pruschy, Michael A Grotzer

Oral tongue cancer gene expression profiling: Identification of novel potential prognosticators by oligonucleotide microarray analysis

Open Access
Research article

Cherry L Estilo, Pornchai O-charoenrat, Simon Talbot, Nicholas D Socci, Diane L Carlson, Ronald Ghossein, Tijaana Williams, Yoshihiro Yonekawa, Yegnanarayana Ramanathan, Jay O Boyle, Dennis H Kraus, Snehal Patel, Ashok R Shaha, Richard J Wong, Joseph M Huryn, Jatin P Shah, Bhuvanesh Singh

Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion

Open Access
Research article

Sanjay Sachdev, Yahao Bu, Irwin H Gelman

Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer

Open Access
Research article

Ying-Fang Sun, Jyh-Der Leu, Su-Mei Chen, I-Feng Lin, Yi-Jang Lee

Impact of age, leukocyte count and day 21-bone marrow response to chemotherapy on the long-term outcome of children with philadelphia chromosome-positive acute lymphoblastic leukemia in the pre-imatinib era: results of the FRALLE 93 study

Open Access
Study protocol

Virginie Gandemer, Marie-Francoise Auclerc, Yves Perel, Jean-Pierre Vannier, Edouard Le Gall, Francois Demeocq, Claudine Schmitt, Christophe Piguet, Jean-Louis Stephan, Odile Lejars, Marianne Debre, Philippe Jonveaux, Jean-Michel Cayuela, Sylvie Chevret, Guy Leverger, Andre Baruchel

Cured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: A population based case-control study

Open Access
Research article

Chen-yu Liu, Yi-Hsiang Hsu, Ming-Tsang Wu, Pi-Chen Pan, Chi-Kung Ho, Li Su, Xin Xu, Yi Li, David C Christiani

Identification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen

Open Access
Research article

Ze-jun Lu, Qi-fang Song, Sa-sa Jiang, Qi Song, Wei Wang, Gao-hua Zhang, Bin Kan, Lan-tu Gou, Li-juan Chen, Feng Luo, Zhi Yong Qian, Jin-liang Yang, Yu Quan Wei

Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors

Open Access
Research article

Suvi Savola, Arto Klami, Abhishek Tripathi, Tarja Niini, Massimo Serra, Piero Picci, Samuel Kaski, Diana Zambelli, Katia Scotlandi, Sakari Knuutila

The value of diffusion-weighted imaging in assessing the ADC changes of tissues adjacent to breast carcinoma

Open Access
Research article

Zhang Yili, Huang Xiaoyan, Du Hongwen, Zhang Yun, Chen Xin, Wang Peng, Guo Youmin

Freund's vaccine adjuvant promotes Her2/Neu breast cancer

Open Access
Research article

Michelle S Cotroneo, Jill D Haag, Nicholas R Stapel, Jordy L Waller, Stephan Woditschka, Michael N Gould

Correlation between MMPs and their inhibitors in breast cancer tumor tissue specimens and in cell lines with different metastatic potential

Open Access
Research article

Rita CS Figueira, Luciana R Gomes, João S Neto, Fabricio C Silva, Ismael DCG Silva, Mari C Sogayar

A positioning pillow to improve lumbar puncture success rate in paediatric haematology-oncology patients: a randomized controlled trial

Open Access
Research article

Perrine Marec-Bérard, Alvine Bissery, Kamila Kebaïli, Matthias Schell, Françoise Aubert, Ségolène Gaillard, Muriel Rabilloud, Behrouz Kassaï, Catherine Cornu

Gene expression profiling of alveolar soft-part sarcoma (ASPS)

Open Access
Research article

Luke H Stockwin, David T Vistica, Susan Kenney, David S Schrump, Donna O Butcher, Mark Raffeld, Robert H Shoemaker

Total laparoscopic hysterectomy versus abdominal hysterectomy in the treatment of patients with early stage endometrial cancer: A randomized multi center study

Open Access
Study protocol

Claudia BM Bijen, Justine M Briët, Geertruida H de Bock, Henriëtte JG Arts, Johanna A Bergsma-Kadijk, Marian JE Mourits

Qualitative analysis of Adenomatous Polyposis Coli promoter: Hypermethylation, engagement and effects on survival of patients with esophageal cancer in a high risk region of the world, a potential molecular marker

Open Access
Research article

Maryam Zare, Ferdous Rastgar Jazii, Mohammad Reza Alivand, Negin Karimi Nasseri, Reza Malekzadeh, Mansour Yazdanbod

Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression

Open Access
Research article

Søren A Jensen, Ben Vainer, Mogens Kruhøffer, Jens B Sørensen

Human Papillomavirus (HPV) in breast tumors: prevalence in a group of Mexican patients

Open Access
Research article

David Cantu de León, Delia Pérez Montiel, Jana Nemcova, Iva Mykyskova, Elmer Turcios, Verónica Villavicencio, Lucely Cetina, Alberto Coronel, Ondraj Hes

The critical role of ERK in death resistance and invasiveness of hypoxia-selected glioblastoma cells

Open Access
Research article

Jee-Youn Kim, Yong-Jun Kim, Sun Lee, Jae-Hoon Park

Certified causes of death in patients with mesothelioma in South East England

Open Access
Research article

Catherine Okello, Tom Treasure, Andrew G Nicholson, Julian Peto, Henrik Møller

The intraportal injection model: A practical animal model for hepatic metastases and tumor cell dissemination in human colon cancer

Open Access
Research article

Andreas Thalheimer, Christoph Otto, Marco Bueter, Bertram Illert, Stefan Gattenlohner, Martin Gasser, Detlef Meyer, Martin Fein, Christoph T Germer, Ana M Waaga-Gasser

Characterization of SV-40 Tag rats as a model to study prostate cancer

Open Access
Research article

Curt E Harper, Brijesh B Patel, Leah M Cook, Jun Wang, Tomoyuki Shirai, Isam A Eltoum, Coral A Lamartiniere

Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines

Open Access
Research article

Huining Tan, Yili Zhong, Zhongzong Pan

Clinical significance of altered nm23-H1, EGFR, RB and p53 expression in bilharzial bladder cancer

Open Access
Research article

Hussein M Khaled, Abeer A Bahnassy, Amira A Raafat, Abdel-Rahman N Zekri, Maha S Madboul, Nadia M Mokhtar

Early and very early hepatocellular carcinoma: when and how much do staging and choice of treatment really matter? A multi-center study

Open Access
Research article

Fabio Farinati, Adriana Sergio, Anna Baldan, Anna Giacomin, Maria Anna Di Nolfo, Paolo Del Poggio, Luisa Benvegnu, Gianludovico Rapaccini, Marco Zoli, Franco Borzio, Edoardo G Giannini, Eugenio Caturelli, Franco Trevisani

Metastatic renal cell cancer treatments: An indirect comparison meta-analysis

Open Access
Research article

Edward J Mills, Beth Rachlis, Chris O'Regan, Lehana Thabane, Dan Perri

The association between RCAS1 expression in laryngeal and pharyngeal cancer and its healthy stroma with cancer relapse

Open Access
Research article

Magdalena Dutsch-Wicherek, Romana Tomaszewska, Agata Lazar, Lukasz Wicherek, Jacek Skladzien

Establishing the added benefit of measuring MMP9 in FOB positive patients as a part of the Wolverhampton colorectal cancer screening programme

Open Access
Study protocol

Sue Wilson, Taina Taskila, Tariq Ismail, Deborah D Stocken, Ashley Martin, Val Redman, Michael Wakelam, Ian Perry, Richard Hobbs

Bioelectrical impedance phase angle in clinical practice: implications for prognosis in stage IIIB and IV non-small cell lung cancer

Open Access
Research article

Digant Gupta, Carolyn A Lammersfeld, Pankaj G Vashi, Jessica King, Sadie L Dahlk, James F Grutsch, Christopher G Lis

Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay

Open Access
Research article

Louise A Knight, Christian M Kurbacher, Sharon Glaysher, Augusta Fernando, Ralf Reichelt, Susanne Dexel, Uwe Reinhold, Ian A Cree

Disclosure of cancer diagnosis and quality of life in cancer patients: should it be the same everywhere?

Open Access
Research article

Ali Montazeri, Azadeh Tavoli, Mohammad Ali Mohagheghi, Rasool Roshan, Zahra Tavoli

Increased PADI4 expression in blood and tissues of patients with malignant tumors

Open Access
Research article

Xiaotian Chang, Jinxiang Han, Li Pang, Yan Zhao, Yi Yang, Zhonglin Shen

Identification of a potent herbal molecule for the treatment of breast cancer

Open Access
Research article

Srinivas Koduru, Srinivasan Sowmyalakshmi, Raj Kumar, Rohini Gomathinayagam, Jürgen Rohr, Chendil Damodaran

Coherent anti-Stokes Raman scattering imaging of lipids in cancer metastasis

Open Access
Research article

Thuc T Le, Terry B Huff, Ji-Xin Cheng

Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort

Open Access
Research article

Christopher A Haiman, Rachel R Garcia, Chris Hsu, Lucy Xia, Helen Ha, Xin Sheng, Loic Le Marchand, Laurence N Kolonel, Brian E Henderson, Michael R Stallcup, Geoffrey L Greene, Michael F Press

Specific gene expression profiles and chromosomal abnormalities are associated with infant disseminated neuroblastoma

Open Access
Research article

Cinzia Lavarino, Nai-Kong V Cheung, Idoia Garcia, Gema Domenech, Carmen de Torres, Miguel Alaminos, Jose Rios, William L Gerald, Brian Kushner, Mike LaQuaglia, Jaume Mora

Secretion of MCP-1 and other paracrine factors in a novel tumor-bone coculture model

Open Access
Research article

Katherine R Schiller, Marion R Zillhardt, Jeremy Alley, Dori L Borjesson, Alvin J Beitz, Laura J Mauro

Survival and hepatitis status among Asian Americans with hepatocellular carcinoma treated without liver transplantation

Open Access
Research article

Jessica P Hwang, Manal M Hassan

Risk factors for lower limb lymphedema after lymph node dissection in patients with ovarian and uterine carcinoma

Open Access
Research article

Harue Tada, Satoshi Teramukai, Masanori Fukushima, Hiroshi Sasaki

High resolution human leukocyte antigen (HLA) class I and class II allele typing in Mexican mestizo women with sporadic breast cancer: case-control study

Open Access
Research article

David Cantú de León, Delia Pérez-Montiel, Verónica Villavicencio, Alejandro García Carranca, Alejandro Mohar Betancourt, Victor Acuña-Alonzo, Alberto López-Tello, Gilberto Vargas-Alarcón, Rodrigo Barquera, Neng Yu, Edmond J Yunis, Julio Granados

Suitable reference genes for real-time PCR in human HBV-related hepatocellular carcinoma with different clinical prognoses

Open Access
Research article

Li-Yun Fu, Hu-Liang Jia, Qiong-Zhu Dong, Jin-Cai Wu, Yue Zhao, Hai-Jun Zhou, Ning Ren, Qin-Hai Ye, Lun-Xiu Qin

Preoperative short-course radiotherapy versus combined radiochemotherapy in locally advanced rectal cancer: a multi-centre prospectively randomised study of the Berlin Cancer Society

Open Access
Study protocol

Robert Siegel, Susen Burock, Klaus-Dieter Wernecke, Albrecht Kretzschmar, Manfred Dietel, Volker Loy, Stephan Koswig, Volker Budach, Peter M Schlag

Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status

Open Access
Research article

Seon-Ah Ha, Youn Soo Lee, Seung Min Shin, Hyun Kee Kim, Sanghee Kim, Hong Namkoong, Hae Joo Kim, Sang Min Jung, Yu Sun Lee, Yeun Jun Chung, Sang Seol Jung, Jin Woo Kim

Loss of full length CtBP1 expression enhances the invasive potential of human melanoma

Open Access
Research article

Andreas Winklmeier, Ina Poser, Keith S Hoek, Anja K Bosserhoff

The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines

Open Access
Research article

Patricia Mambou Gwanmesia, Annette Romanski, Kerstin Schwarz, Biserka Bacic, Martin Ruthardt, Oliver G Ottmann

Arrested neural and advanced mesenchymal differentiation of glioblastoma cells-comparative study with neural progenitors

Open Access
Research article

Piotr Rieske, Ewa Golanska, Magdalena Zakrzewska, Sylwester Piaskowski, Krystyna Hulas-Bigoszewska, Magdalena Wolańczyk, Malgorzata Szybka, Monika Witusik-Perkowska, Dariusz J Jaskolski, Krzysztof Zakrzewski, Wojciech Biernat, Barbara Krynska, Pawel P Liberski

Dynamic distribution and expression in vivo of the human interferon gamma gene delivered by adenoviral vector

Open Access
Research article

Jiangxue Wu, Xia Xiao, Hongyun Jia, Jiemin Chen, Yinghui Zhu, Peng Zhao, Huanxin Lin, Wenlin Huang

Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells

Open Access
Research article

Zhen-Xian Du, Hai-Yan Zhang, Xin Meng, Yifu Guan, Hua-Qin Wang

Absence of polysialylated NCAM is an unfavorable prognostic phenotype for advanced stage neuroblastoma

Open Access
Research article

Miikka Korja, Anne Jokilammi, Toivo T Salmi, Hannu Kalimo, Tarja-Terttu Pelliniemi, Jorma Isola, Immo Rantala, Hannu Haapasalo, Jukka Finne

Two mechanisms of the enhanced antibody-dependent cellular cytotoxicity (ADCC) efficacy of non-fucosylated therapeutic antibodies in human blood

Open Access
Research article

Shigeru Iida, Reiko Kuni-Kamochi, Katsuhiro Mori, Hirofumi Misaka, Miho Inoue, Akira Okazaki, Kenya Shitara, Mitsuo Satoh

The carboxyl terminal trimer of procollagen I induces pro-metastatic changes and vascularization in breast cancer cells xenografts

Open Access
Research article

Davide Visigalli, Daniela Palmieri, Antonella Strangio, Simonetta Astigiano, Ottavia Barbieri, Gianluigi Casartelli, Antonio Zicca, Paola Manduca

Effects of the single nucleotide polymorphism at MDM2 309 on breast cancer patients with/without BRCA1/2 mutations

Open Access
Research article

Hovav Nechushtan, Tamar Hamburger, Susan Mendelson, Luna Kadouri, Nir Sharon, Eli Pikarsky, Tamar Peretz

Expression of Bmi-1 is a prognostic marker in bladder cancer

Open Access
Research article

Zi-Ke Qin, Jian-An Yang, Yun-lin Ye, Xing Zhang, Li-Hua Xu, Fang-Jian Zhou, Hui Han, Zuo-Wei Liu, Li-Bing Song, Mu-Sheng Zeng

Role of BRCA2 mutation status on overall survival among breast cancer patients from Sardinia

Open Access
Research article

Mario Budroni, Rosaria Cesaraccio, Vincenzo Coviello, Ornelia Sechi, Daniela Pirino, Antonio Cossu, Francesco Tanda, Marina Pisano, Grazia Palomba, Giuseppe Palmieri

ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC

Open Access
Research article

Luke H Stockwin, Sherry X Yu, Howard Stotler, Melinda G Hollingshead, Dianne L Newton

Clinical implications of increased lymph vessel density in the lymphatic metastasis of early-stage invasive cervical carcinoma: a clinical immunohistochemical method study

Open Access
Research article

Shi-qian Zhang, Hao Yu, Lin-lin Zhang

Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion

Open Access
Research article

Murat Cokakli, Esra Erdal, Deniz Nart, Funda Yilmaz, Ozgul Sagol, Murat Kilic, Sedat Karademir, Nese Atabey

Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I131KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma

Open Access
Research article

Asma Sultana, Susannah Shore, Michael GT Raraty, Sobhan Vinjamuri, Jonathan E Evans, Catrin Tudur Smith, Steven Lane, Seema Chauhan, Lorraine Bosonnet, Conall Garvey, Robert Sutton, John P Neoptolemos, Paula Ghaneh

Expression of verotoxin-1 receptor Gb3 in breast cancer tissue and verotoxin-1 signal transduction to apoptosis

Open Access
Research article

David Johansson, Eldina Kosovac, Jasmin Moharer, Ingrid Ljuslinder, Thomas Brännström, Anders Johansson, Parviz Behnam-Motlagh

Rectal cancer treatment and outcome in the elderly: an audit based on the Swedish rectal cancer registry 1995–2004

Open Access
Research article

Bärbel Jung, Lars Påhlman, Robert Johansson, Erik Nilsson

Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer

Open Access
Research article

Phillip L Ross, Iona Cheng, Xin Liu, Mine S Cicek, Peter R Carroll, Graham Casey, John S Witte

Clustering of cancer among families of cases with Hodgkin Lymphoma (HL), Multiple Myeloma (MM), Non-Hodgkin's Lymphoma (NHL), Soft Tissue Sarcoma (STS) and control subjects

Open Access
Research article

Helen H McDuffie, Punam Pahwa, Chandima P Karunanayake, John J Spinelli, James A Dosman

Loss of heterozygosity of TRIM3 in malignant gliomas

Open Access
Research article

Jean-Louis Boulay, Urs Stiefel, Elisabeth Taylor, Béatrice Dolder, Adrian Merlo, Frank Hirth

Differential expression of topoisomerase IIα protein in salivary gland carcinomas: histogenetic and prognostic implications

Open Access
Research article

Shin-ichiro Maruya, Takashi Shirasaki, Takahiko Nagaki, Seiji Kakehata, Hidekachi Kurotaki, Hiroki Mizukami, Hideichi Shinkawa

The role of PET/CT in detection of gastric cancer recurrence

Open Access
Research article

Sung Hoon Sim, Yu Jung Kim, Do-Youn Oh, Se-Hoon Lee, Dong-Wan Kim, Won Jun Kang, Seock-Ah Im, Tae-You Kim, Woo Ho Kim, Dae Seog Heo, Yung-Jue Bang

Functional characterization of E- and P-cadherin in invasive breast cancer cells

Open Access
Research article

David Sarrió, José Palacios, Marta Hergueta-Redondo, Gonzalo Gómez-López, Amparo Cano, Gema Moreno-Bueno

Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factors

Open Access
Research article

Yuanguang Meng, Chenglei Gu, Zhiqiang Wu, Yali Zhao, Yiling Si, Xiaobing Fu, Weidong Han

Knowledge of risk factors, beliefs and practices of female healthcare professionals towards breast cancer in a tertiary institution in Lagos, Nigeria

Open Access
Research article

Nasiru A Ibrahim, Olumuyiwa O Odusanya

Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia

Open Access
Research article

Anne Margrete Øyan, Nina Ånensen, Trond Hellem Bø, Laila Stordrange, Inge Jonassen, Øystein Bruserud, Karl-Henning Kalland, Bjørn Tore Gjertsen

The prognostic value of four interleukin-1 gene polymorphisms in caucasian women with breast cancer – a multicenter study

Open Access
Research article

Christoph Grimm, Eva Kantelhardt, Georg Heinze, Stephan Polterauer, Robert Zeillinger, Heinz Kölbl, Alexander Reinthaller, Lukas Hefler

The high affinity selectin glycan ligand C2-O-sLex and mRNA transcripts of the core 2 β-1,6-N-acetylglusaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas

Open Access
Research article

Catherine A St Hill, Mariya Farooqui, Gregory Mitcheltree, H Evin Gulbahce, Jose Jessurun, Qing Cao, Bruce Walcheck

ADAM33 gene silencing by promoter hypermethylation as a molecular marker in breast invasive lobular carcinoma

Open Access
Research article

Gerusa G Seniski, Anamaria A Camargo, Daniela F Ierardi, Edneia AS Ramos, Mariana Grochoski, Enilze SF Ribeiro, Iglenir J Cavalli, Fabio O Pedrosa, Emanuel M de Souza, Silvio M Zanata, Fabrício F Costa, Giseli Klassen

Characterization of STAT3 activation and expression in canine and human osteosarcoma

Open Access
Research article

Stacey L Fossey, Albert T Liao, Jennifer K McCleese, Misty D Bear, Jiayuh Lin, Pui-Kai Li, William C Kisseberth, Cheryl A London

Sunitinib treatment for patients with clear-cell metastatic renal cell carcinoma: clinical outcomes and plasma angiogenesis markers

Open Access
Research article

Loukas F Kontovinis, Konstantinos T Papazisis, Panagiota Touplikioti, Charalambos Andreadis, Despoina Mouratidou, Alexandros H Kortsaris

APRIL is overexpressed in cancer: link with tumor progression

Open Access
Research article

Jérôme Moreaux, Jean-Luc Veyrune, John De Vos, Bernard Klein

Breast cancer epidemiology according to recognized breast cancer risk factors in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial Cohort

Open Access
Research article

James V Lacey Jr, Aimee R Kreimer, Saundra S Buys, Pamela M Marcus, Shih-Chen Chang, Michael F Leitzmann, Robert N Hoover, Philip C Prorok, Christine D Berg, Patricia Hartge

Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice

Open Access
Research article

Hae-Ran Park, Eun-Jin Ju, Sung-Kee Jo, Uhee Jung, Sung-Ho Kim, Sung-Tae Yee

The prevalence of BRCA1 mutations among young women with triple-negative breast cancer

Open Access
Research article

SR Young, Robert T Pilarski, Talia Donenberg, Charles Shapiro, Lyn S Hammond, Judith Miller, Karen A Brooks, Stephanie Cohen, Beverly Tenenholz, Damini DeSai, Inuk Zandvakili, Robert Royer, Song Li, Steven A Narod

Overexpression of UbcH10 alternates the cell cycle profile and accelerate the tumor proliferation in colon cancer

Open Access
Research article

Takeo Fujita, Hirokuni Ikeda, Naruto Taira, Shinji Hatoh, Minoru Naito, Hiroyoshi Doihara

Circulating cell death products predict clinical outcome of colorectal cancer patients

Open Access
Research article

Pim J Koelink, Cornelis BHW Lamers, Daan W Hommes, Hein W Verspaget

Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats

Open Access
Research article

Stuart G Baker, Ana M Soto, Carlos Sonnenschein, Antonio Cappuccio, John D Potter, Barnett S Kramer

Quantitative real-time RT-PCR and chromogenic in situ hybridization: precise methods to detect HER-2 status in breast carcinoma

Open Access
Research article

Fabíola E Rosa, Sara M Silveira, Cássia GT Silveira, Nádia A Bérgamo, Francisco A Moraes Neto, Maria AC Domingues, Fernando A Soares, José RF Caldeira, Silvia R Rogatto

Population based prostate cancer screening in north Mexico reveals a high prevalence of aggressive tumors in detected cases

Open Access
Research article

Lauro S Gomez-Guerra, Margarita L Martinez-Fierro, Valeria Alcantara-Aragon, Rocio Ortiz-Lopez, Rebeca T Martinez-Villarreal, Idelma B Morales-Rodriguez, Raquel Garza-Guajardo, Marco A Ponce-Camacho, Augusto Rojas-Martinez

Androgen deprivation modulates the inflammatory response induced by irradiation

Open Access
Research article

Chun-Te Wu, Wen-Cheng Chen, Paul-Yang Lin, Shuen-Kuei Liao, Miao-Fen Chen

QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study

Open Access
Research article

Nora Hinsch, Matthias Frank, Claudia Döring, Christian Vorländer, Martin-Leo Hansmann

Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins

Open Access
Research article

Remedios Castelló-Cros, David R Khan, Jeffrey Simons, Matthildi Valianou, Edna Cukierman

Microvessel density as new prognostic marker after radiotherapy in rectal cancer

Open Access
Research article

Saulius Svagzdys, Vaiva Lesauskaite, Dainius Pavalkis, Irena Nedzelskienė, Darius Pranys, Algimantas Tamelis

MRM screening/biomarker discovery with linear ion trap MS: a library of human cancer-specific peptides

Open Access
Research article

Xu Yang, Iulia M Lazar

Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma

Open Access
Research article

Gilda Raguénez, Annick Mühlethaler-Mottet, Roland Meier, Caroline Duros, Jean Bénard, Nicole Gross

Estimation of age- and stage-specific Catalan breast cancer survival functions using US and Catalan survival data

Open Access
Research article

Ester Vilaprinyo, Montserrat Rué, Rafael Marcos-Gragera, Montserrat Martínez-Alonso

New structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cells

Open Access
Research article

Ling Cen, Brian Hutzen, Sarah Ball, Stephanie DeAngelis, Chun-Liang Chen, James R Fuchs, Chenglong Li, Pui-Kai Li, Jiayuh Lin

Regulation of HSP27 on NF-κB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis

Open Access
Research article

Kun Guo, Nan Xiao Kang, Yan Li, Lu Sun, Lin Gan, Feng Jie Cui, Mei Dong Gao, Kun Yin Liu

Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation

Open Access
Research article

Alessandra Fabi, Giulio Metro, Michelangelo Russillo, Antonello Vidiri, Carmine Maria Carapella, Marta Maschio, Francesco Cognetti, Bruno Jandolo, Maria Alessandra Mirri, Isabella Sperduti, Stefano Telera, Mariantonia Carosi, Andrea Pace

Up-regulation of bone marrow stromal protein 2 (BST2) in breast cancer with bone metastasis

Open Access
Research article

Dongqing Cai, Jie Cao, Zhen Li, Xin Zheng, Yao Yao, Wanglin Li, Ziqiang Yuan

The subcellular localization of IGFBP5 affects its cell growth and migration functions in breast cancer

Open Access
Research article

Mustafa Akkiprik, Limei Hu, Aysegul Sahin, Xishan Hao, Wei Zhang

Prediction of breast cancer by profiling of urinary RNA metabolites using Support Vector Machine-based feature selection

Open Access
Research article

Carsten Henneges, Dino Bullinger, Richard Fux, Natascha Friese, Harald Seeger, Hans Neubauer, Stefan Laufer, Christoph H Gleiter, Matthias Schwab, Andreas Zell, Bernd Kammerer

Prognostic scores in brain metastases from breast cancer

Open Access
Research article

Carsten Nieder, Kirsten Marienhagen, Sabrina T Astner, Michael Molls

Complementarity of ultrasound and fluorescence imaging in an orthotopic mouse model of pancreatic cancer

Open Access
Research article

Cynthia S Snyder, Sharmeela Kaushal, Yuko Kono, Hop S Tran Cao, Robert M Hoffman, Michael Bouvet

Rosiglitazone synergizes anticancer activity of cisplatin and reduces its nephrotoxicity in 7, 12-dimethyl benz{a}anthracene (DMBA) induced breast cancer rats

Open Access
Research article

Kulbhushan Tikoo, Parveen Kumar, Jeena Gupta

Classifying breast cancer surgery: a novel, complexity-based system for oncological, oncoplastic and reconstructive procedures, and proof of principle by analysis of 1225 operations in 1166 patients

Open Access
Research article

Jürgen Hoffmann, Diethelm Wallwiener

Immunostaining with D2–40 improves evaluation of lymphovascular invasion, but may not predict sentinel lymph node status in early breast cancer

Open Access
Research article

Anna V Britto, André A Schenka, Natália G Moraes-Schenka, Marcelo Alvarenga, Júlia Y Shinzato, José Vassallo, Laura S Ward

A retrospective analysis of second-line chemotherapy in patients with advanced gastric cancer

Open Access
Research article

Sang Hoon Ji, Do Hyoung Lim, Seong Yoon Yi, Hyo Song Kim, Hyun Jung Jun, Kyoung Ha Kim, Myung Hee Chang, Min Jae Park, Ji Eun Uhm, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang

KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay

Open Access
Research article

Veronika Auner, Gernot Kriegshäuser, Dan Tong, Reinhard Horvat, Alexander Reinthaller, Alexander Mustea, Robert Zeillinger

Cetuximab in combination with irinotecan/5-fluorouracil/folinic acid (FOLFIRI) in the initial treatment of metastatic colorectal cancer: a multicentre two-part phase I/II study

Open Access
Research article

Jean-Luc Raoul, Jean-Luc Van Laethem, Marc Peeters, Catherine Brezault, Fares Husseini, Laurent Cals, Johannes Nippgen, Anja-Helena Loos, Philippe Rougier

Contamination and sample mix-up can best explain some patterns of mtDNA instabilities in buccal cells and oral squamous cell carcinoma

Open Access
Correspondence

Hans-Jürgen Bandelt, Antonio Salas

Activation of P2X7-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice

Open Access
Research article

Wen Fu, Tom McCormick, Xiaoping Qi, Liping Luo, Lingyin Zhou, Xin Li, Bing-Cheng Wang, Heidi E Gibbons, Fadi W Abdul-Karim, George I Gorodeski

CYP17, GSTP1, PON1 and GLO1gene polymorphisms as risk factors for breast cancer: an Italian case-control study

Open Access
Research article

Cinzia Antognelli, Chiara Del Buono, Vienna Ludovini, Stefania Gori, Vincenzo N Talesa, Lucio Crinò, Francesco Barberini, Antonio Rulli

The effect of comorbidity on the use of adjuvant chemotherapy and survival from colon cancer: a retrospective cohort study

Open Access
Research article

Diana Sarfati, Sarah Hill, Tony Blakely, Bridget Robson, Gordon Purdie, Elizabeth Dennett, Donna Cormack, Kevin Dew

Return to work of breast cancer survivors: a systematic review of intervention studies

Open Access
Research article

JL Hoving, MLA Broekhuizen, MHW Frings-Dresen

Revisiting perioperative chemotherapy: the critical importance of targeting residual cancer prior to wound healing

Open Access
Debate

William W Harless

Brain metastasis development and poor survival associated with carcinoembryonic antigen (CEA) level in advanced non-small cell lung cancer: a prospective analysis

Open Access
Research article

Oscar Arrieta, David Saavedra-Perez, Roberto Kuri, Alejandro Aviles-Salas, Luis Martinez, Daniel Mendoza-Posada, Patricia Castillo, Alma Astorga, Enrique Guzman, Jaime De la Garza

Capecitabine plus Irinotecan (XELIRI regimen) compared to 5-FU/LV plus Irinotecan (FOLFIRI regimen) as neoadjuvant treatment for patients with unresectable liver-only metastases of metastatic colorectal cancer: a randomised prospective phase II trial

Open Access
Research article

Erik Skof, Martina Rebersek, Zvezdana Hlebanja, Janja Ocvirk

Bone sialoprotein does not interact with pro-gelatinase A (MMP-2) or mediate MMP-2 activation

Open Access
Research article

Queena Hwang, Sela Cheifetz, Christopher M Overall, Christopher A McCulloch, Jaro Sodek

Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women

Open Access
Research article

Enbo Ma, Motoki Iwasaki, Ishihara Junko, Gerson Shigeaki Hamada, Ines Nobuko Nishimoto, Solange Maria Torchia Carvalho, Juvenal Motola Jr, Fábio Martins Laginha, Shoichiro Tsugane

Quantitation of DNA methylation by melt curve analysis

Open Access
Technical advance

Eric Smith, Michael E Jones, Paul A Drew

Association between the NBS1E185Q polymorphism and cancer risk: a meta-analysis

Open Access
Research article

Meixia Lu, Jiachun Lu, Xiaobo Yang, Miao Yang, Hao Tan, Bai Yun, Luyuan Shi

Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma

Open Access
Research article

Claudia Augello, Luca Caruso, Marco Maggioni, Matteo Donadon, Marco Montorsi, Roberto Santambrogio, Guido Torzilli, Valentina Vaira, Caterina Pellegrini, Massimo Roncalli, Guido Coggi, Silvano Bosari

Tumor-directed gene therapy in mice using a composite nonviral gene delivery system consisting of the piggyBac transposon and polyethylenimine

Open Access
Research article

Yu Kang, Xiaoyan Zhang, Wei Jiang, Chaoqun Wu, Chunmei Chen, Yufang Zheng, Jianren Gu, Congjian Xu

Oncologist use of the Adjuvant! model for risk communication: a pilot study examining patient knowledge of 10-year prognosis

Open Access
Research article

Jeffrey K Belkora, Hope S Rugo, Dan H Moore, David W Hutton, Daniel F Chen, Laura J Esserman

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

Open Access
Research article

Ines J Marques, Frank Ulrich Weiss, Danielle H Vlecken, Claudia Nitsche, Jeroen Bakkers, Anne K Lagendijk, Lars Ivo Partecke, Claus-Dieter Heidecke, Markus M Lerch, Christoph P Bagowski

Age-standardized incidence and mortality rates of oral and pharyngeal cancer in Puerto Rico and among Non-Hispanics Whites, Non-Hispanic Blacks, and Hispanics in the USA

Open Access
Research article

Erick Suárez, William A Calo, Eduardo Y Hernández, Elba C Diaz, Nayda R Figueroa, Ana P Ortiz

Eligibility of patients with advanced non-small cell lung cancer for phase III chemotherapy trials

Open Access
Research article

Janette Vardy, Ryan Dadasovich, Philip Beale, Michael Boyer, Stephen J Clarke

Validation of a prognostic scoring system for locally recurrent nasopharyngeal carcinoma treated by stereotactic radiosurgery

Open Access
Research article

Daniel TT Chua, Kwan-Ngai Hung, Victor Lee, Sherry CY Ng, Janice Tsang

Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy

Open Access
Research article

Shadi Mamaghani, Satish Patel, David W Hedley

siRNA inhibition of telomerase enhances the anti-cancer effect of doxorubicin in breast cancer cells

Open Access
Research article

Xuejun Dong, Anding Liu, Cindy Zer, Jianguo Feng, Zhuan Zhen, Mingfeng Yang, Li Zhong

Clinical significance of Neutrophil gelatinase-associated lipocalin(NGAL) expression in primary rectal cancer

Open Access
Research article

Xiu-Feng Zhang, Ying Zhang, Xiao-Hua Zhang, Su-Mei Zhou, Guan-Gen Yang, Ou-Chen Wang, Gui-Long Guo, Gao-Yi Yang, Xiao-Qu Hu

Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library

Open Access
Research article

Ming-Szu Hung, Zhidong Xu, Yu-Ching Lin, Jian-Hua Mao, Cheng-Ta Yang, Pey-Jium Chang, David M Jablons, Liang You

Collagen mRNA levels changes during colorectal cancer carcinogenesis

Open Access
Research article

Hanne Skovbjerg, Dorit Anthonsen, Inger MB Lothe, Kjell M Tveit, Elin H Kure, Lotte K Vogel

A case-control study on the combined effects of p53 and p73 polymorphisms on head and neck cancer risk in an Italian population

Open Access
Research article

Paola Gallì, Gabriella Cadoni, Mariangela Volante, Emma De Feo, Rosarita Amore, Arianna Giorgio, Dario Arzani, Gaetano Paludetti, Gualtiero Ricciardi, Stefania Boccia

δ-ALA-D activity is a reliable marker for oxidative stress in bone marrow transplant patients

Open Access
Research article

Thissiane L Gonçalves, Dalila M Benvegnú, Gabriela Bonfanti, Andressa V Frediani, João Batista T Rocha

Does the availability of positron emission tomography modify diagnostic strategies for solitary pulmonary nodules? An observational study in France

Open Access
Research article

Irawati Lemonnier, Cédric Baumann, Nicolas Jay, Kazem Alzahouri, Patrick Arveux, Damien Jolly, Catherine Lejeune, Michel Velten, Fabien Vitry, Marie-Christine Woronoff-Lemsi, Francis Guillemin

Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study

Open Access
Research article

Karin Broberg, Elizabeth Huynh, Karin Schläwicke Engström, Jonas Björk, Maria Albin, Christian Ingvar, Håkan Olsson, Mattias Höglund

Ethnicity and incidence of Hodgkin lymphoma in Canadian population

Open Access
Research article

Punam Pahwa, Chandima P Karunanayake, John J Spinelli, James A Dosman, Helen H McDuffie

MP470, a novel receptor tyrosine kinase inhibitor, in combination with Erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancer

Open Access
Research article

Wenqing Qi, Larry S Cooke, Amy Stejskal, Christopher Riley, Kimiko Della Croce, Jose W Saldanha, David Bearss, Daruka Mahadevan

Expression of Hyaluronan Synthases (HAS1–3) and Hyaluronidases (HYAL1–2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content

Open Access
Research article

Timo K Nykopp, Kirsi Rilla, Reijo Sironen, Markku I Tammi, Raija H Tammi, Kirsi Hämäläinen, Anna-Mari Heikkinen, Marja Komulainen, Veli-Matti Kosma, Maarit Anttila

The -271 G>A polymorphism of kinase insert domain-containing receptor gene regulates its transcription level in patients with non-small cell lung cancer

Open Access
Research article

She-Juan An, Zhi-Hong Chen, Qiu-Xiong Lin, Jian Su, Hua-Jun Chen, Jia-Ying Lin, Yi-Long Wu

A gene expression predictor of response to EGFR-targeted therapy stratifies progression-free survival to cetuximab in KRAS wild-type metastatic colorectal cancer

Open Access
Research article

Justin M Balko, Esther P Black

Safety and preliminary efficacy data of a novel Casein Kinase 2 (CK2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies

Open Access
Research article

Ana M Solares, Agueda Santana, Idania Baladrón, Carmen Valenzuela, Carlos A González, Alina Díaz, Dagnelia Castillo, Thelvia Ramos, Roberto Gómez, Daniel F Alonso, Luis Herrera, Hugo Sigman, Silvio E Perea, Boris E Acevedo, Pedro López-Saura

Both SEPT2 and MLL are down-regulated in MLL-SEPT2therapy-related myeloid neoplasia

Open Access
Research article

Nuno Cerveira, Joana Santos, Susana Bizarro, Vera Costa, Franclim R Ribeiro, Susana Lisboa, Cecília Correia, Lurdes Torres, Joana Vieira, Simone Snijder, José M Mariz, Lucília Norton, Clemens H Mellink, Arjan Buijs, Manuel R Teixeira

Aromatase expression is increased in BRCA1mutation carriers

Open Access
Research article

Ashwini L Chand, Evan R Simpson, Colin D Clyne

Chromosomal imbalance in the progression of high-risk non-muscle invasive bladder cancer

Open Access
Research article

Karsten Zieger, Carsten Wiuf, Klaus Møller-Ernst Jensen, Torben Falck Ørntoft, Lars Dyrskjøt

An integrative multi-platform analysis for discovering biomarkers of osteosarcoma

Open Access
Research article

Guodong Li, Wenjuan Zhang, Huazong Zeng, Lei Chen, Wenjing Wang, Jilong Liu, Zhiyu Zhang, Zhengdong Cai

Selective microdochectomy after ductoscopic wire marking in women with pathological nipple discharge

Open Access
Research article

M Hahn, T Fehm, EF Solomayer, KC Siegmann, AS Hengstmann, D Wallwiener, R Ohlinger

High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas

Open Access
Research article

Maria V Yusenko, Roland P Kuiper, Tamas Boethe, Börje Ljungberg, Ad Geurts van Kessel, Gyula Kovacs

Inflammatory (B) symptoms are independent predictors of myelosuppression from chemotherapy in Non-Hodgkin Lymphoma (NHL) patients – analysis of data from a British National Lymphoma Investigation phase III trial comparing CHOP to PMitCEBO

Open Access
Research article

Rohini Sharma, David Cunningham, Paul Smith, Graham Robertson, Owen Dent, Stephen J Clarke

Potential antitumor effects of nitrogen-containing bisphosphonate in hormone receptor negative breast cancer patients with bone metastases

Open Access
Research article

In Hae Park, Jungsil Ro, Byung Ho Nam, Youngmi Kwon, Keun Seok Lee

Clinical significances of preoperative serum interleukin-6 and C-reactive protein level in operable gastric cancer

Open Access
Research article

Do-Kyong Kim, Sung Yong Oh, Hyuk-Chan Kwon, Suee Lee, Kyung A Kwon, Byung Geun Kim, Seong-Geun Kim, Sung-Hyun Kim, Jin Seok Jang, Min Chan Kim, Kyeong Hee Kim, Jin-Yeong Han, Hyo-Jin Kim

A phase II experience with neoadjuvant irinotecan (CPT-11), 5-fluorouracil (5-FU) and leucovorin (LV) for colorectal liver metastases

Open Access
Research article

Oliver F Bathe, Scott Ernst, Francis R Sutherland, Elijah Dixon, Charles Butts, David Bigam, David Holland, Geoffrey A Porter, Jennifer Koppel, Scot Dowden

Loss of heterozygosity at thymidylate synthase locus in Barrett's metaplasia, dysplasia, and carcinoma sequences

Open Access
Research article

Hidekazu Kuramochi, Kazumi Uchida, Jeffery H Peters, Daisuke Shimizu, Daniel Vallbohmer, Sylke Schneider, Kathleen D Danenberg, Peter V Danenberg

IGF-I activates caspases 3/7, 8 and 9 but does not induce cell death in colorectal cancer cells

Open Access
Research article

Shi Yu Yang, Capucine Bolvin, Kevin M Sales, Barry Fuller, Alexander M Seifalian, Marc C Winslet

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression

Open Access
Research article

Laura Arce, Kira T Pate, Marian L Waterman

A Randomized Multicentre Phase II Trial Comparing Adjuvant Therapy in Patients with Interferon Alpha-2b and 5-FU Alone or in Combination with Either External Radiation Treatment and Cisplatin (CapRI) or Radiation alone regarding Event-Free Survival – CapRI-2

Open Access
Study protocol

Angela Märten, Jan Schmidt, Jennifer Ose, Sabine Harig, Ulrich Abel, Marc W Münter, Dirk Jäger, Helmut Friess, Julia Mayerle, Guido Adler, Thomas Seufferlein, Thomas Gress, Roland Schmid, Markus W Büchler

Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and growth of renal cell carcinoma cells

Open Access
Research article

Eva Juengel, Johanna Engler, Iyad Natsheh, Jon Jones, Ausra Mickuckyte, Lukasz Hudak, Dietger Jonas, Roman A Blaheta

The 14-3-3σ gene promoter is methylated in both human melanocytes and melanoma

Open Access
Research article

Suhu Liu, Paul Howell, Suping Ren, Oystein Fodstad, Adam I Riker

Expression of miR-21 and its targets (PTEN, PDCD4, TM1) in flat epithelial atypia of the breast in relation to ductal carcinoma in situ and invasive carcinoma

Open Access
Research article

Liqiang Qi, Joost Bart, Lu Ping Tan, Inge Platteel, Tineke van der Sluis, Sippie Huitema, Geert Harms, Li Fu, Harry Hollema, Anke van den Berg

Do serum biomarkers really measure breast cancer?

Open Access
Research article

Jonathan L Jesneck, Sayan Mukherjee, Zoya Yurkovetsky, Merlise Clyde, Jeffrey R Marks, Anna E Lokshin, Joseph Y Lo

Inter-observer reproducibility of HER2 immunohistochemical assessment and concordance with fluorescent in situhybridization (FISH): pathologist assessment compared to quantitative image analysis

Open Access
Research article

Gulisa Turashvili, Samuel Leung, Dmitry Turbin, Kelli Montgomery, Blake Gilks, Rob West, Melinda Carrier, David Huntsman, Samuel Aparicio

Chondromodulin-1 directly suppresses growth of human cancer cells

Open Access
Research article

Hisashi Mera, Hiroyuki Kawashima, Tatsuya Yoshizawa, Osamu Ishibashi, Md Moksed Ali, Tadashi Hayami, Hiroshi Kitahara, Hiroshi Yamagiwa, Naoki Kondo, Akira Ogose, Naoto Endo, Hiroyuki Kawashima

Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma

Open Access
Research article

Anxun Wang, Xiqiang Liu, Shihu Sheng, Hui Ye, Tingsheng Peng, Fei Shi, David L Crowe, Xiaofeng Zhou

Survival analysis of 1148 women diagnosed with breast cancer in Southern Iran

Open Access
Research article

Abbas Rezaianzadeh, Janet Peacock, Daniel Reidpath, Abdolrasoul Talei, Seyed Vahid Hosseini, Davood Mehrabani

Differential baseline and response profile to IFN-γ gene transduction of IL-6/IL-6 receptor-α secretion discriminate primary tumors versus bone marrow metastases of nasopharyngeal carcinomas in culture

Open Access
Research article

Andy Shau-Bin Chou, Hsin-Yi Wang, Hung-Chang Chen, Ming-Hsiu Tsai, Cheng-Keng Chuang, Shuen-Kuei Liao

Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer

Open Access
Research article

Kristin L White, Robert A Vierkant, Catherine M Phelan, Brooke L Fridley, Stephanie Anderson, Keith L Knutson, Joellen M Schildkraut, Julie M Cunningham, Linda E Kelemen, V Shane Pankratz, David N Rider, Mark Liebow, Lynn C Hartmann, Thomas A Sellers, Ellen L Goode

Neoadjuvant chemotherapy or primary surgery for stage III/IV ovarian cancer: contribution of diagnostic laparoscopy

Open Access
Research article

Jean-Luc Brun, Roman Rouzier, Frédéric Selle, Sidney Houry, Serge Uzan, Emile Daraï

Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study

Open Access
Research article

Hongmei Nan, Abrar A Qureshi, David J Hunter, Jiali Han

Inhibitor of differentiation 4 (Id4) is a potential tumor suppressor in prostate cancer

Open Access
Research article

Jason PW Carey, Ananthi J Asirvatham, Oliver Galm, Tandeih A Ghogomu, Jaideep Chaudhary

Effect of staurosporine on the mobility and invasiveness of lung adenocarcinoma A549 cells: an in vitro study

Open Access
Research article

Yanyan Wang, Hongfa Yang, Hongbin Liu, Ji Huang, Xingfu Song

Expression of BNIP3 in invasive breast cancer: correlations with the hypoxic response and clinicopathological features

Open Access
Research article

Esther A Koop, Theo van Laar, Dick F van Wichen, Roel A de Weger, Elsken van der Wall, Paul J van Diest

Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival

Open Access
Research article

Zuo-lin Xiang, Zhao-chong Zeng, Zhao-you Tang, Jia Fan, Peng-yuan Zhuang, Ying Liang, Yun-shan Tan, Jian He

The effectiveness of the Screening Inventory of Psychosocial Problems (SIPP) in cancer patients treated with radiotherapy: design of a cluster randomised controlled trial

Open Access
Study protocol

Anna PBM Braeken, Lilian Lechner, Francis CJM van Gils, Ruud MA Houben, Daniëlle Eekers, Ton Ambergen, Gertrudis IJM Kempen

Cytoplasmic Kaiso is associated with poor prognosis in non-small cell lung cancer

Open Access
Research article

Shun-Dong Dai, Yan Wang, Yuan Miao, Yue Zhao, Yong Zhang, Gui-Yang Jiang, Peng-Xin Zhang, Zhi-Qiang Yang, En-Hua Wang

Fast simultaneous detection of K-RASmutations in colorectal cancer

Open Access
Technical advance

Ya-Sian Chang, Kun-Tu Yeh, Tien-Jye Chang, Connie Chai, Hsiu-Chin Lu, Nicholas C Hsu, Jan-Gowth Chang

Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription (STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer

Open Access
Research article

Hester van Cruijsen, Mariëlle Gallegos Ruiz, Paul van der Valk, Tanja D de Gruijl, Giuseppe Giaccone

Variations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2French Canadian families with high risk of breast cancer

Open Access
Research article

Sylvie Desjardins, Joly Charles Beauparlant, Yvan Labrie, Geneviève Ouellette, Francine Durocher

Mammographic density and epithelial histopathologic markers

Open Access
Research article

Martijn Verheus, Gertraud Maskarinec, Eva Erber, Jana S Steude, Jeffrey Killeen, Brenda Y Hernandez, J Mark Cline

The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells

Open Access
Research article

Bodil Fadnes, Øystein Rekdal, Lars Uhlin-Hansen

Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas

Open Access
Research article

Maartje Nielsen, Noel FCC de Miranda, Marjo van Puijenbroek, Ekaterina S Jordanova, Anneke Middeldorp, Tom van Wezel, Ronald van Eijk, Carli MJ Tops, Hans FA Vasen, Frederik J Hes, Hans Morreau

In situaromatase expression in primary tumor is associated with estrogen receptor expression but is not predictive of response to endocrine therapy in advanced breast cancer

Open Access
Research article

Anne E Lykkesfeldt, Katrine L Henriksen, Birgitte B Rasmussen, Hironobu Sasano, Dean B Evans, Susanne Møller, Bent Ejlertsen, Henning T Mouridsen

Low NKp30, NKp46 and NKG2D expression and reduced cytotoxic activity on NK cells in cervical cancer and precursor lesions

Open Access
Research article

Trinidad Garcia-Iglesias, Alicia del Toro-Arreola, Benibelks Albarran-Somoza, Susana del Toro-Arreola, Pedro E Sanchez-Hernandez, Maria Guadalupe Ramirez-Dueñas, Luz Ma. Adriana Balderas-Peña, Alejandro Bravo-Cuellar, Pablo C Ortiz-Lazareno, Adrian Daneri-Navarro

Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention

Open Access
Review

Vasilis P Androutsopoulos, Aristidis M Tsatsakis, Demetrios A Spandidos

Expression of matrix metalloproteinases (MMPs) in primary human breast cancer and breast cancer cell lines: New findings and review of the literature

Open Access
Research article

Andrea Köhrmann, Ulrike Kammerer, Michaela Kapp, Johannes Dietl, Jelena Anacker

Beating the blues after Cancer: randomised controlled trial of a tele-based psychological intervention for high distress patients and carers

Open Access
Study protocol

Suzanne K Chambers, Afaf Girgis, Stefano Occhipinti, Sandy Hutchison, Jane Turner, Rob Carter, Jeff Dunn

Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells

Open Access
Research article

Eileen Looby, Mohamed MM Abdel-Latif, Veronica Athié-Morales, Shane Duggan, Aideen Long, Dermot Kelleher

Induction of protective and therapeutic anti-pancreatic cancer immunity using a reconstructed MUC1 DNA vaccine

Open Access
Research article

Yefei Rong, Dayong Jin, Wenchuan Wu, Wenhui Lou, Danshong Wang, Tiantao Kuang, Xiaoling Ni, Xinyu Qin

Triple negative breast carcinoma is a prognostic factor in Taiwanese women

Open Access
Research article

Che Lin, Su-Yu Chien, Li-Sheng Chen, Shou-Jen Kuo, Tsai-Wang Chang, Dar-Ren Chen

The TGFBR1*6A allele is not associated with susceptibility to colorectal cancer in a Spanish population: a case-control study

Open Access
Research article

Adela Castillejo, Trinidad Mata-Balaguer, Paola Montenegro, Enrique Ochoa, Rafael Lázaro, Ana Martínez-Cantó, María-Isabel Castillejo, Carla Guarinos, Víctor-Manuel Barberá, Carmen Guillén-Ponce, Alfredo Carrato, José-Luís Soto

Systematic validation of predicted microRNAs for cyclin D1

Open Access
Research article

Qiong Jiang, Ming-Guang Feng, Yin-Yuan Mo

Case report: Malignant teratoma of the uterine corpus

Open Access
Case report

Thomas Newsom-Davis, Daniel Poulter, Rebecca Gray, Mohammed Ameen, Iain Lindsay, Kyriakos Papanikolaou, Simon Butler-Manuel, Timothy Christmas, Peter Townsend, Michael Seckl

KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?

Open Access
Research article

Silvia Valensin, Chiara Ghiron, Claudia Lamanna, Andreas Kremer, Marco Rossi, Pietro Ferruzzi, Marco Nievo, Annette Bakker

The Ets dominant repressor En/Erm enhances intestinal epithelial tumorigenesis in ApcMin mice

Open Access
Research article

Paul Jedlicka, Xiaomei Sui, Arthur Gutierrez-Hartmann

A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth

Open Access
Research article

Hiroaki Mita, Minoru Toyota, Fumio Aoki, Hirofumi Akashi, Reo Maruyama, Yasushi Sasaki, Hiromu Suzuki, Masashi Idogawa, Lisa Kashima, Kazuyoshi Yanagihara, Masahiro Fujita, Masao Hosokawa, Masanobu Kusano, Sorin Vasile Sabau, Haruyuki Tatsumi, Kohzoh Imai, Yasuhisa Shinomura, Takashi Tokino

P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients

Open Access
Research article

Ruoping Tang, Simy Cohen, Jean-Yves Perrot, Anne-Marie Faussat, Claudia Zuany-Amorim, Zora Marjanovic, Hamid Morjani, Fanny Fava, Elise Corre, Ollivier Legrand, Jean-Pierre Marie

Production and characterisation of monoclonal antibodies against RAI3 and its expression in human breast cancer

Open Access
Technical advance

Hannah Jörißen, Nuran Bektas, Edgar Dahl, Arndt Hartmann, Anette ten Haaf, Stefano Di Fiore, Hans Kiefer, Andreas Thess, Stefan Barth, Torsten Klockenbring

Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis

Open Access
Research article

Joanna Selzer-Plon, Jette Bornholdt, Stine Friis, Hanne C Bisgaard, Inger MB Lothe, Kjell M Tveit, Elin H Kure, Ulla Vogel, Lotte K Vogel

Breast cancer stem cells: tools and models to rely on

Open Access
Review

Emmanuelle Charafe-Jauffret, Christophe Ginestier, Daniel Birnbaum

Knowledge, attitudes and practice of breast cancer screening among female health workers in a Nigerian urban city

Open Access
Research article

Adenike O Akhigbe, Vivian O Omuemu

249 TP53 mutation has high prevalence and is correlated with larger and poorly differentiated HCC in Brazilian patients

Open Access
Research article

Jeronimo A Nogueira, Suzane K Ono-Nita, Marcelo E Nita, Marcelo MT de Souza, Eliane P do Carmo, Evandro S Mello, Cristovan Scapulatempo, Denise C Paranaguá-Vezozzo, Flair J Carrilho, Venancio AF Alves

Liposarcoma: exploration of clinical prognostic factors for risk based stratification of therapy

Open Access
Research article

Hyo Song Kim, Jeeyun Lee, Seong Yoon Yi, Hyun Jung Jun, Yoon-La Choi, Geung Hwan Ahn, Sung Wook Seo, Do Hoon Lim, Yong Chan Ahn, Joon Oh Park, Sung Joo Kim

Identification of proteins involved in neural progenitor cell targeting of gliomas

Open Access
Research article

Karin Staflin, Thole Zuchner, Gabriella Honeth, Anna Darabi, Cecilia Lundberg

Proneoplastic effects of PGE2mediated by EP4 receptor in colorectal cancer

Open Access
Research article

Glen A Doherty, Sinead M Byrne, Eamonn S Molloy, Vikrum Malhotra, Sandra C Austin, Elaine W Kay, Frank E Murray, Desmond J Fitzgerald

Early MRI response monitoring of patients with advanced hepatocellular carcinoma under treatment with the multikinase inhibitor sorafenib

Open Access
Research article

Marius Horger, Ulrich M Lauer, Christina Schraml, Christoph P Berg, Ursula Koppenhöfer, Claus D Claussen, Michael Gregor, Michael Bitzer

The epidemiology and survival of extrapulmonary small cell carcinoma in South East England, 1970–2004

Open Access
Research article

Yien Ning S Wong, Ruth H Jack, Vivian Mak, Møller Henrik, Elizabeth A Davies

A phase III clinical trial of exercise modalities on treatment side-effects in men receiving therapy for prostate cancer

Open Access
Study protocol

Robert U Newton, Dennis R Taaffe, Nigel Spry, Robert A Gardiner, Gregory Levin, Bradley Wall, David Joseph, Suzanne K Chambers, Daniel A Galvão

A simple method for co-segregation analysis to evaluate the pathogenicity of unclassified variants; BRCA1 and BRCA2 as an example

Open Access
Research article

Leila Mohammadi, Maaike P Vreeswijk, Rogier Oldenburg, Ans van den Ouweland, Jan C Oosterwijk, Annemarie H van der Hout, Nicoline Hoogerbrugge, Marjolijn Ligtenberg, Margreet G Ausems, Rob B van der Luijt, Charlotte J Dommering, Johan J Gille, Senno Verhoef, Frans B Hogervorst, Theo A van Os, Encarna Gómez García, Marinus J Blok, Juul T Wijnen, Quinta Helmer, Peter Devilee, Christi J van Asperen, Hans C van Houwelingen

Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma

Open Access
Research article

Adhemar Longatto-Filho, Céline Pinheiro, Olga Martinho, Marise AR Moreira, Luiz FJ Ribeiro, Geraldo S Queiroz, Fernando C Schmitt, Fátima Baltazar, Rui M Reis

CXCR4 expression on circulating pan-cytokeratin positive cells is associated with survival in patients with advanced non-small cell lung cancer

Open Access
Research article

Karen L Reckamp, Robert A Figlin, Marie D Burdick, Steven M Dubinett, Robert M Elashoff, Robert M Strieter

Intrinsic bias in breast cancer gene expression data sets

Open Access
Research article

Jonathan D Mosley, Ruth A Keri

The prosurvival role of autophagy in Resveratrol-induced cytotoxicity in human U251 glioma cells

Open Access
Research article

Jun Li, Zhenghong Qin, Zhongqin Liang

Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study

Open Access
Research article

Jeongseon Kim, Sun-Young Lim, Aesun Shin, Mi-Kyung Sung, Jungsil Ro, Han-Sung Kang, Keun Seok Lee, Seok-Won Kim, Eun-Sook Lee

Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer

Open Access
Research article

Jürgen Veeck, Peter J Wild, Thomas Fuchs, Peter J Schüffler, Arndt Hartmann, Ruth Knüchel, Edgar Dahl

Response of the primary tumor in symptomatic and asymptomatic stage IV colorectal cancer to combined interventional endoscopy and palliative chemotherapy

Open Access
Research article

Silke Cameron, Diana Hünerbein, Tümen Mansuroglu, Thomas Armbrust, Jens-Gerd Scharf, Harald Schwörer, László Füzesi, Giuliano Ramadori

DDEC: Dragon database of genes implicated in esophageal cancer

Open Access
Database

Magbubah Essack, Aleksandar Radovanovic, Ulf Schaefer, Sebastian Schmeier, Sundararajan V Seshadri, Alan Christoffels, Mandeep Kaur, Vladimir B Bajic

Neuropilin-2 expression in breast cancer: correlation with lymph node metastasis, poor prognosis, and regulation of CXCR4 expression

Open Access
Research article

Hironao Yasuoka, Rieko Kodama, Masahiko Tsujimoto, Katsuhide Yoshidome, Hiroki Akamatsu, Masaaki Nakahara, Michiya Inagaki, Tokio Sanke, Yasushi Nakamura

CD133 antigen expression in ovarian cancer

Open Access
Research article

Gabriella Ferrandina, Enrica Martinelli, Marco Petrillo, Maria Grazia Prisco, Gianfranco Zannoni, Stefano Sioletic, Giovanni Scambia

Health – related quality of life of Kuwaiti women with breast cancer: a comparative study using the EORTC Quality of Life Questionnaire

Open Access
Research article

Shafika A Alawadi, Jude U Ohaeri

Integrin α6Bβ4 inhibits colon cancer cell proliferation and c-Myc activity

Open Access
Research article

Anders Bondo Dydensborg, Inga C Teller, Jean-François Groulx, Nuria Basora, Fréderic Paré, Elizabeth Herring, Rémy Gauthier, Dominique Jean, Jean-François Beaulieu

Downregulation of SFRP5 expression and its inverse correlation with those of MMP-7 and MT1-MMP in gastric cancer

Open Access
Research article

Chenghai Zhao, Xianmin Bu, Ning Zhang, Wei Wang

Molecular fingerprinting of radiation resistant tumors: Can we apprehend and rehabilitate the suspects?

Open Access
Review

Charles J Rosser, Micah Gaar, Stacy Porvasnik

The potential biomarkers in predicting pathologic response of breast cancer to three different chemotherapy regimens: a case control study

Open Access
Research article

Linbo Wang, Zhinong Jiang, Meihua Sui, Jianguo Shen, Chaoyang Xu, Weimin Fan

Factors associated with improved survival among older colorectal cancer patients in the US: a population-based analysis

Open Access
Research article

Kathleen Lang, Jonathan R Korn, David W Lee, Lisa M Lines, Craig C Earle, Joseph Menzin

Certification of breast centres in Germany: proof of concept for a prototypical example of quality assurance in multidisciplinary cancer care

Open Access
Research article

Sara Y Brucker, Michael Bamberg, Walter Jonat, Matthias W Beckmann, Andreas Kämmerle, Rolf Kreienberg, Diethelm Wallwiener

Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes

Open Access
Research article

Valentina Bangiyeva, Ava Rosenbloom, Ashlynn E Alexander, Bella Isanova, Timothy Popko, Alan R Schoenfeld

Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer

Open Access
Research article

Eva Verjans, Erik Noetzel, Nuran Bektas, Anke K Schütz, Hongqi Lue, Birgitt Lennartz, Arndt Hartmann, Edgar Dahl, Jürgen Bernhagen

Simultaneous Foxp3 and IDO expression is associated with sentinel lymph node metastases in breast cancer

Open Access
Research article

Aaron S Mansfield, Paivi S Heikkila, Ari T Vaara, Karl AJ von Smitten, Jukka M Vakkila, Marjut HK Leidenius

Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma

Open Access
Research article

Hideaki Shimada, Tooru Shiratori, Mari Yasuraoka, Akiko Kagaya, Mari Kuboshima, Fumio Nomura, Masaki Takiguchi, Takenori Ochiai, Hisahiro Matsubara, Takaki Hiwasa

Expression of ezrin is associated with invasion and dedifferentiation of hepatitis B related hepatocellular carcinoma

Open Access
Research article

Chun-Nan Yeh, See-Tong Pang, Tsung-Wen Chen, Ren-Ching Wu, Wen-Hui Weng, Miin-Fu Chen

Characterization of MCF mammary epithelial cells overexpressing the Arylhydrocarbon receptor (AhR)

Open Access
Research article

Patrick S Wong, Wen Li, Christoph F Vogel, Fumio Matsumura

Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction – A model for cross-modulation

Open Access
Research article

Honor J Hugo, Razan Wafai, Tony Blick, Erik W Thompson, Donald F Newgreen

Low-risk susceptibility alleles in 40 human breast cancer cell lines

Open Access
Research article

Muhammad Riaz, Fons Elstrodt, Antoinette Hollestelle, Abbas Dehghan, Jan GM Klijn, Mieke Schutte

Identification of novel candidate target genes, including EPHB3, MASP1 and SSTat 3q26.2–q29 in squamous cell carcinoma of the lung

Open Access
Research article

Ji Un Kang, Sun Hoe Koo, Kye Chul Kwon, Jong Woo Park, Jin Man Kim

The role of TNFgenetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study

Open Access
Research article

Jae Jeong Yang, Kwang-Pil Ko, Lisa Y Cho, Aesun Shin, Jin Gwack, Soung-Hoon Chang, Hai-Rim Shin, Keun-Young Yoo, Daehee Kang, Sue K Park

Regulation of MYCNexpression in human neuroblastoma cells

Open Access
Research article

Joannes FM Jacobs, Hans van Bokhoven, Frank N van Leeuwen, Christina A Hulsbergen-van de Kaa, I Jolanda M de Vries, Gosse J Adema, Peter M Hoogerbrugge, Arjan PM de Brouwer

Twist expression promotes migration and invasion in hepatocellular carcinoma

Open Access
Research article

Noriyuki Matsuo, Hidenori Shiraha, Tatsuya Fujikawa, Nobuyuki Takaoka, Naoki Ueda, Shigetomi Tanaka, Shinichi Nishina, Yutaka Nakanishi, Masayuki Uemura, Akinobu Takaki, Shinichiro Nakamura, Yoshiyuki Kobayashi, Kazuhiro Nouso, Takahito Yagi, Kazuhide Yamamoto

GLUT1 gene is a potential hypoxic marker in colorectal cancer patients

Open Access
Research article

Fu-Yen Chung, Ming-Yii Huang, Ching-Sheng Yeh, Hui-Jen Chang, Tian-Lu Cheng, Li-Chen Yen, Jaw-Yuan Wang, Shiu-Ru Lin

A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivoglioblastoma models

Open Access
Research article

Ahcene Boumendjel, Anne McLeer-Florin, Pierre Champelovier, Diane Allegro, Dima Muhammad, Florence Souard, Madiha Derouazi, Vincent Peyrot, Bertrand Toussaint, Jean Boutonnat

Low expression of a few genes indicates good prognosis in estrogen receptor positive breast cancer

Open Access
Research article

Steven Buechler

Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer

Open Access
Research article

Jianghong Li, Cheryl A Sherman-Baust, Miyun Tsai-Turton, Robert E Bristow, Richard B Roden, Patrice J Morin

A role of BRCA1 and BRCA2germline mutations in breast cancer susceptibility within Sardinian population

Open Access
Research article

Grazia Palomba, Angela Loi, Antonella Uras, Patrizia Fancello, Giovanna Piras, Attilio Gabbas, Antonio Cossu, Mario Budroni, Antonio Contu, Francesco Tanda, Antonio Farris, Sandra Orrù, Carlo Floris, Marina Pisano, Mario Lovicu, Maria Cristina Santona, Gennaro Landriscina, Laura Crisponi, Giuseppe Palmieri, Maria Monne

Carbonic anhydrase 9 is a predictive marker of survival benefit from lower dose of bevacizumab in patients with previously treated metastatic colorectal cancer

Open Access
Research article

Yong Sang Hong, Hyeon Jin Cho, Sun Young Kim, Kyung Hae Jung, Ji Won Park, Hyo Seong Choi, Jae Hwan Oh, Byung Chang Kim, Dae Kyung Sohn, Dae Yong Kim, Hee Jin Chang

Establishment and characterization of pleomorphic adenoma cell systems: an in-vitro demonstration of carcinomas arising secondarily from adenomas in the salivary gland

Open Access
Research article

Satoshi Maruyama, Jun Cheng, Susumu Shingaki, Takashi Tamura, Shuichi Asakawa, Shinsei Minoshima, Yoshiko Shimizu, Nobuyoshi Shimizu, Takashi Saku

Brain-type and liver-type fatty acid-binding proteins: new tumor markers for renal cancer?

Open Access
Research article

Angelika Tölle, Monika Jung, Michael Lein, Manfred Johannsen, Kurt Miller, Holger Moch, Klaus Jung, Glen Kristiansen

Efficacy of sorafenib on metastatic renal cell carcinoma in Asian patients: Results from a multicenter study

Open Access
Research article

Hailiang Zhang, Baijun Dong, Jiade J Lu, Xudong Yao, Shilin Zhang, Bo Dai, Yijun Shen, Yao Zhu, Dingwei Ye, Yiran Huang

Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice

Open Access
Research article

Tai-Guo Liu, Ying Huang, Dan-Dan Cui, Xiao-Bing Huang, Shu-Hua Mao, Ling-Ling Ji, Hai-Bo Song, Cheng Yi

Cyclophilin C-associated protein (CyCAP) knock-out mice spontaneously develop colonic mucosal hyperplasia and exaggerated tumorigenesis after treatment with carcinogen azoxymethane1

Open Access
Research article

Emina Emilia Torlakovic, Vicki Keeler, Chang Wang, Hyun J Lim, Leslie Ann Lining, Suzanne Laferté

The incidence of and mortality from leukaemias in the UK: a general population-based study

Open Access
Research article

Fatima Bhayat, Emma Das-Gupta, Chris Smith, Tricia McKeever, Richard Hubbard

Mammaglobin B is an independent prognostic marker in epithelial ovarian cancer and its expression is associated with reduced risk of disease recurrence

Open Access
Research article

Renata A Tassi, Stefano Calza, Antonella Ravaggi, Eliana Bignotti, Franco E Odicino, Germana Tognon, Carla Donzelli, Marcella Falchetti, Elisa Rossi, Paola Todeschini, Chiara Romani, Elisabetta Bandiera, Laura Zanotti, Sergio Pecorelli, Alessandro D Santin

Standardized and reproducible methodology for the comprehensive and systematic assessment of surgical resection margins during breast-conserving surgery for invasive breast cancer

Open Access
Research article

Stephen P Povoski, Rafael E Jimenez, Wenle P Wang, Ronald X Xu

Pancreatic cancerrelated cachexia: influence on metabolism and correlation to weight loss and pulmonary function

Open Access
Research article

Jeannine Bachmann, Knut Ketterer, Christiane Marsch, Kerstin Fechtner, Holger Krakowski-Roosen, Markus W Büchler, Helmut Friess, Marc E Martignoni

The relation between smokeless tobacco and cancer in Northern Europe and North America. A commentary on differences between the conclusions reached by two recent reviews

Open Access
Correspondence

Peter N Lee, Jan Hamling

Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)

Open Access
Research article

Federico Canzian, Rudolf Kaaks, David G Cox, Katherine D Henderson, Brian E Henderson, Christine Berg, Sheila Bingham, Heiner Boeing, Julie Buring, Eugenia E Calle, Stephen Chanock, Francoise Clavel-Chapelon, Laure Dossus, Heather Spencer Feigelson, Christopher A Haiman, Susan E Hankinson, Robert Hoover, David J Hunter, Claudine Isaacs, Per Lenner, Eiliv Lund, Kim Overvad, Domenico Palli, Celeste Leigh Pearce, Jose R Quiros, Elio Riboli, Daniel O Stram, Gilles Thomas, Michael J Thun, Dimitrios Trichopoulos, Carla H van Gils, Regina G Ziegler

Role of KCNMA1gene in breast cancer invasion and metastasis to brain

Open Access
Research article

Divya Khaitan, Umesh T Sankpal, Babette Weksler, Edward A Meister, Ignacio A Romero, Pierre-Olivier Couraud, Nagendra S Ningaraj

Citrus auraptene suppresses cyclin D1 and significantly delays N-methyl nitrosourea induced mammary carcinogenesis in female Sprague-Dawley rats

Open Access
Research article

Prasad Krishnan, Karen J Yan, David Windler, Jesse Tubbs, Robert Grand, Benjamin DL Li, C Marcelo Aldaz, Jerry McLarty, Heather E Kleiner-Hancock

Malignant transformation of oral potentially malignant disorders in males: a retrospective cohort study

Open Access
Research article

Pei-Shan Ho, Pai-Li Chen, Saman Warnakulasuriya, Tien-Yu Shieh, Yun-Kwan Chen, I-Yueh Huang

Assessment of the effect of betaine on p16 and c-mycDNA methylation and mRNA expression in a chemical induced rat liver cancer model

Open Access
Database

Yan-ping Du, Jun-sheng Peng, Ai Sun, Zhi-hong Tang, Wen-hua Ling, Hui-lian Zhu

Treatment of advanced, recurrent, resistant to previous treatments basal and squamous cell skin carcinomas with a synergistic formulation of interferons. Open, prospective study

Open Access
Research article

Lorenzo Anasagasti-Angulo, Yanelda Garcia-Vega, Silvia Barcelona-Perez, Pedro Lopez-Saura, Iraldo Bello-Rivero

Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma

Open Access
Research article

Robert M Eager, C Casey Cunningham, Neil N Senzer, Joe Stephenson Jr, Stephen P Anthony, Steven J O'Day, Gary Frenette, Anna C Pavlick, Barry Jones, Margaret Uprichard, John Nemunaitis

Evaluation of DNA ploidy in relation with established prognostic factors in patients with locally advanced (unresectable) or metastatic pancreatic adenocarcinoma: a retrospective analysis

Open Access
Research article

Nikolas Tsavaris, Nicolaos Kavantzas, Kostantinos Tsigritis, Ioannis D Xynos, Nikitas Papadoniou, Andreas Lazaris, Christos Kosmas, George Agrogiannis, Anna Dokou, Evangelos Felekouras, Efstathios Antoniou, Aris Polyzos, John Sarantonis, Heracles Tsipras, Gavrilos Karatzas, Alexandros Papalambros, Efstratios S Patsouris

Confocal Microscopy of Unfixed Breast Needle Core Biopsies: A Comparison to Fixed and Stained Sections

Open Access
Research article

Linda M Schiffhauer, J Neil Boger, Thomas A Bonfiglio, James M Zavislan, Margarita Zuley, Christi Alessi Fox

Epidemiological and some clinical characteristics of neuroblastoma in Mexican children (1996–2005)

Open Access
Research article

Servando Juárez-Ocaña, Virginia Palma-Padilla, Guadalupe González-Miranda, Alicia Georgina Siordia-Reyes, Enrique López-Aguilar, Martha Aguilar-Martínez, Juan Manuel Mejía-Aranguré, Rogelio Carreón-Cruz, Mario Enrique Rendón-Macías, Arturo Fajardo-Gutiérrez

Histological analysis of low dose NMU effects in the rat mammary gland

Open Access
Research article

Tessa J Murray, Angelo A Ucci, Maricel V Maffini, Carlos Sonnenschein, Ana M Soto

Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas

Open Access
Research article

Jingmei Liu, Huimei Lu, Hiroko Ohgaki, Adrian Merlo, Zhiyuan Shen

Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China

Open Access
Research article

Ying Gao, Nan Hu, XiaoYou Han, Carol Giffen, Ti Ding, Alisa Goldstein, Philip Taylor

Increased serum hepcidin-25 level and increased tumor expression of hepcidin mRNA are associated with metastasis of renal cell carcinoma

Open Access
Research article

Takao Kamai, Naohisa Tomosugi, Hideyuki Abe, Kyoko Arai, Ken-Ichiro Yoshida

A proteomic strategy to identify novel serum biomarkers for liver cirrhosis and hepatocellular cancer in individuals with fatty liver disease

Open Access
Research article

Joe Gray, Dipankar Chattopadhyay, Gary S Beale, Gillian L Patman, Luca Miele, Barry P King, Stephen Stewart, Mark Hudson, Christopher P Day, Derek M Manas, Helen L Reeves

Natural history of malignant bone disease in breast cancer and the use of cumulative mean functions to measure skeletal morbidity

Open Access
Research article

Pierre P Major, Richard J Cook, Allan Lipton, Matthew R Smith, Evangelos Terpos, Robert E Coleman

A non-randomized comparison of gemcitabine-based chemoradiation with or without induction chemotherapy for locally advanced squamous cell carcinoma of the head and neck

Open Access
Research article

Pol M Specenier, Joost Weyler, Carl Van Laer, Danielle Van den Weyngaert, Jan Van den Brande, Manon T Huizing, Sevilay Altintas, Jan B Vermorken

Does colon cancer ever metastasize to bone first? a temporal analysis of colorectal cancer progression

Open Access
Research article

Eira S Roth, David T Fetzer, Bruce J Barron, Usha A Joseph, Isis W Gayed, David Q Wan

Human papillomavirus prevalence, viral load and pre-cancerous lesions of the cervix in women initiating highly active antiretroviral therapy in South Africa: a cross-sectional study

Open Access
Research article

Jennifer R Moodley, Deborah Constant, Margaret Hoffman, Anna Salimo, Bruce Allan, Ed Rybicki, Inga Hitzeroth, Anna-Lise Williamson

Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer

Open Access
Research article

Carsten Kempkensteffen, Florian Rudolf Fritzsche, Manfred Johannsen, Steffen Weikert, Stefan Hinz, Manfred Dietel, Marc-Oliver Riener, Holger Moch, Klaus Jung, Hans Krause, Kurt Miller, Glen Kristiansen

Participation of older newly-diagnosed cancer patients in an observational prospective pilot study: an example of recruitment and retention

Open Access
Research article

Martine TE Puts, Johanne Monette, Veronique Girre, Christina Wolfson, Michele Monette, Gerald Batist, Howard Bergman

cDNA sequencing improves the detection of P53 missense mutations in colorectal cancer

Open Access
Research article

Malgorzata Szybka, Magdalena Zakrzewska, Piotr Rieske, Grazyna Pasz-Walczak, Dominika Kulczycka-Wojdala, Izabela Zawlik, Robert Stawski, Dorota Jesionek-Kupnicka, Pawel P Liberski, Radzislaw Kordek

Identification of target genes of transcription factor activator protein 2 gamma in breast cancer cells

Open Access
Research article

He Ailan, Xiao Xiangwen, Ren Daolong, Gan Lu, Ding Xiaofeng, Qiao Xi, Hu Xingwang, Liu Rushi, Zhang Jian, Xiang Shuanglin

The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis

Open Access
Research article

Vita M Golubovskaya, Min Zheng, Li Zhang, Jian-Liang Li, William G Cance

The cyclin-dependent kinase inhibitor 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole induces nongenotoxic, DNA replication-independent apoptosis of normal and leukemic cells, regardless of their p53 status

Open Access
Research article

Valentina Turinetto, Paola Porcedda, Luca Orlando, Mario De Marchi, Antonio Amoroso, Claudia Giachino

Presence of activating KRAS mutations correlates significantly with expression of tumour suppressor genes DCN and TPM1 in colorectal cancer

Open Access
Research article

Vid Mlakar, Gašper Berginc, Metka Volavšek, Zdravko Štor, Miran Rems, Damjan Glavač

Development and validation of a simple questionnaire for the identification of hereditary breast cancer in primary care

Open Access
Research article

Patricia Ashton-Prolla, Juliana Giacomazzi, Aishameriane V Schmidt, Fernanda L Roth, Edenir I Palmero, Luciane Kalakun, Ernestina S Aguiar, Susana M Moreira, Erica Batassini, Vanessa Belo-Reyes, Lavinia Schuler-Faccini, Roberto Giugliani, Maira Caleffi, Suzi Alves Camey

Vasohibin inhibits angiogenic sprouting in vitro and supports vascular maturation processes in vivo

Open Access
Research article

Johann Kern, Michael Steurer, Günther Gastl, Eberhard Gunsilius, Gerold Untergasser

Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ

Open Access
Research article

Yunn-Yi Chen, Sandy DeVries, Joseph Anderson, Juan Lessing, Rebecca Swain, Koei Chin, Veronica Shim, Laura J Esserman, Frederic M Waldman, E Shelley Hwang

A randomised controlled trial of a tele-based lifestyle intervention for colorectal cancer survivors ('CanChange'): study protocol

Open Access
Study protocol

Anna L Hawkes, Kenneth I Pakenham, Kerry S Courneya, Sara Gollschewski, Peter Baade, Louisa G Gordon, Brigid M Lynch, Joanne F Aitken, Suzanne K Chambers

Limitations in SELDI-TOF MS whole serum proteomic profiling with IMAC surface to specifically detect colorectal cancer

Open Access
Research article

Qi Wang, Jing Shen, Zhen-fu Li, Jian-zheng Jie, Wen-yue Wang, Jin Wang, Zhong-tao Zhang, Zhi-xia Li, Li Yan, Jin Gu

Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment

Open Access
Research article

Li-Chu Sun, Koung-Shing Chu, Su-Chen Cheng, Chien-Yu Lu, Chao-Hung Kuo, Jan-Sing Hsieh, Ying-Ling Shih, Shun-Jen Chang, Jaw-Yuan Wang

Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression

Open Access
Research article

Hanna Tuhkanen, Ylermi Soini, Veli-Matti Kosma, Maarit Anttila, Reijo Sironen, Kirsi Hämäläinen, Laura Kukkonen, Ismo Virtanen, Arto Mannermaa

The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters

Open Access
Research article

W Al Sarakbi, W Sasi, WG Jiang, T Roberts, RF Newbold, K Mokbel

Expression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma

Open Access
Research article

Zhu-Qing Zhou, Wei-Hua Cao, Jian-Jun Xie, Jing Lin, Zhong-Ying Shen, Qing-Ying Zhang, Jin-Hui Shen, Li-Yan Xu, En-Min Li

Distribution of immune cells in head and neck cancer: CD8+ T-cells and CD20+B-cells in metastatic lymph nodes are associated with favourable outcome in patients with oro- and hypopharyngeal carcinoma

Open Access
Research article

Dominik Pretscher, Luitpold V Distel, Gerhard G Grabenbauer, Michael Wittlinger, Maike Buettner, Gerald Niedobitek

Stimulation of lymphocyte anti-melanoma activity by co-cultured macrophages activated by complex homeopathic medication

Open Access
Research article

Fernando SF Guimarães, Ana PR Abud, Simone M Oliveira, Carolina C Oliveira, Beatriz César, Lucas F Andrade, Lucélia Donatti, Juarez Gabardo, Edvaldo S Trindade, Dorly F Buchi

Cancer incidence in kidney transplant recipients: a study protocol

Open Access
Study protocol

Salvador Pita-Fernandez, Francisco Valdes-Cañedo, Sonia Pertega-Diaz, Maria Teresa Seoane-Pillado, Rocio Seijo-Bestilleiro

Measuring prostate-specific quality of life in prostate cancer patients scheduled for radiotherapy or radical prostatectomy and reference men in Germany and Canada using the Patient Oriented Prostate Utility Scale-Psychometric (PORPUS-P)

Open Access
Research article

Annika Waldmann, Volker Rohde, Karen Bremner, Murray Krahn, Thomas Kuechler, Alexander Katalinic

Impact of age and comorbidities on health-related quality of life for patients with prostate cancer: evaluation before a curative treatment

Open Access
Research article

Michael Pinkawa, Karin Fischedick, Bernd Gagel, Marc D Piroth, Branka Asadpour, Jens Klotz, Holger Borchers, Gerhard Jakse, Michael J Eble

Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies

Open Access
Research article

Ilse Roodink, Kiek Verrijp, Jos Raats, William PJ Leenders

Expression of the glioma-associated oncogene homolog (GLI) 1in human breast cancer is associated with unfavourable overall survival

Open Access
Research article

Anette ten Haaf, Nuran Bektas, Sonja von Serenyi, Inge Losen, Elfriede Christel Arweiler, Arndt Hartmann, Ruth Knüchel, Edgar Dahl

Electric pulses used in electrochemotherapy and electrogene therapy do not significantly change the expression profile of genes involved in the development of cancer in malignant melanoma cells

Open Access
Research article

Vid Mlakar, Vesna Todorovic, Maja Cemazar, Damjan Glavac, Gregor Sersa

Resistance gene expression determines the in vitro chemosensitivity of non-small cell lung cancer (NSCLC)

Open Access
Research article

Sharon Glaysher, Dennis Yiannakis, Francis G Gabriel, Penny Johnson, Marta E Polak, Louise A Knight, Zoe Goldthorpe, Katharine Peregrin, Mya Gyi, Paul Modi, Joe Rahamim, Mark E Smith, Khalid Amer, Bruce Addis, Matthew Poole, Ajit Narayanan, Tim J Gulliford, Peter E Andreotti, Ian A Cree

A mammalianized synthetic nitroreductase gene for high-level expression

Open Access
Research article

Maik Grohmann, Nils Paulmann, Sebastian Fleischhauer, Jakob Vowinckel, Josef Priller, Diego J Walther

Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma

Open Access
Research article

Sonja Mertsch, Leon J Schurgers, Kathrin Weber, Werner Paulus, Volker Senner

Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis

Open Access
Research article

Mario Scartozzi, Italo Bearzi, Alessandra Mandolesi, Chiara Pierantoni, Fotios Loupakis, Alberto Zaniboni, Francesca Negri, Antonello Quadri, Fausto Zorzi, Eva Galizia, Rossana Berardi, Tommasina Biscotti, Roberto Labianca, Gianluca Masi, Alfredo Falcone, Stefano Cascinu

Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for tumor invasion

Open Access
Research article

Valentina Masola, Claudio Maran, Evelyne Tassone, Angelica Zin, Angelo Rosolen, Maurizio Onisto

Quality of life in patients with gastric cancer: translation and psychometric evaluation of the Iranian version of EORTC QLQ-STO22

Open Access
Research article

Sanamber Sadighi, Ali Montazeri, Zahra Sedighi, Mohammad Ali Mohagheghi, Hossein Froutan

Pediatric differentiated thyroid carcinoma in stage I: risk factor analysis for disease free survival

Open Access
Research article

Nobuyuki Wada, Kiminori Sugino, Takashi Mimura, Mitsuji Nagahama, Wataru Kitagawa, Hiroshi Shibuya, Keiko Ohkuwa, Hirotaka Nakayama, Shohei Hirakawa, Yasushi Rino, Munetaka Masuda, Koichi Ito

Histological evaluation of AMPK signalling in primary breast cancer

Open Access
Research article

Sirwan M Hadad, Lee Baker, Philip R Quinlan, Katherine E Robertson, Susan E Bray, George Thomson, David Kellock, Lee B Jordan, Colin A Purdie, David G Hardie, Stewart Fleming, Alastair M Thompson

RNOP-09: Pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma - a phase II study

Open Access
Research article

Christoph P Beier, Christina Schmid, Thierry Gorlia, Christine Kleinletzenberger, Dagmar Beier, Oliver Grauer, Andreas Steinbrecher, Birgit Hirschmann, Alexander Brawanski, Christopher Dietmaier, Tanja Jauch-Worley, Oliver Kölbl, Torsten Pietsch, Martin Proescholdt, Petra Rümmele, Armin Muigg, Günther Stockhammer, Monika Hegi, Ulrich Bogdahn, Peter Hau

A protein-based set of reference markers for liver tissues and hepatocellular carcinoma

Open Access
Research article

Stella Sun, Xin Yi, Ronnie TP Poon, Chun Yeung, Philip JR Day, John M Luk

Biomarkers of apoptosis and survival in esophageal squamous cell carcinoma

Open Access
Research article

Mikiko Takikita, Nan Hu, Jian-zhong Shou, Quan-Hong Wang, Carol Giffen, Philip R Taylor, Stephen M Hewitt

Darbepoetin alfa for treating chemotherapy-induced anemia in patients with a baseline hemoglobin level < 10 g/dL versus ≥10 g/dL: an exploratory analysis from a randomized, double-blind, active-controlled trial

Open Access
Research article

Johan Vansteenkiste, Michael Hedenus, Pere Gascon, Carsten Bokemeyer, Heinz Ludwig, Jan Vermorken, Lisa Hamilton, Ken Bridges, Beatriz Pujol

No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer

Open Access
Research article

Ellen L Goode, Csilla Szabo, Ludmila Prokunina-Olsson, Robert A Vierkant, Zachary S Fredericksen, Francis S Collins, Kristin L White, Michele Schmidt, Brooke L Fridley, Fergus J Couch

Concurrent intra-arterial carboplatin administration and radiation therapy for the treatment of advanced head and neck squamous cell carcinoma: short term results

Open Access
Research article

Giulia Bertino, Antonio Occhini, Carlo Emilio Falco, Camillo Porta, Franco Corbella, Sara Colombo, Vittoria Balcet, Patrizia Morbini, Federico Zappoli, Andrea Azzaretti, Giuseppe Rodolico, Carmine Tinelli, Marco Benazzo

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605

Open Access
Research article

William N Pappano, Paul M Jung, Jonathan A Meulbroek, Yi-Chun Wang, Robert D Hubbard, Qian Zhang, Meagan M Grudzien, Niru B Soni, Eric F Johnson, George S Sheppard, Cherrie Donawho, Fritz G Buchanan, Steven K Davidsen, Randy L Bell, Jieyi Wang

Cripto-1 overexpression is involved in the tumorigenesis of nasopharyngeal carcinoma

Open Access
Research article

Zhengrong Wu, Gang Li, Lirong Wu, Desheng Weng, Xiangping Li, Kaitai Yao

The striking geographical pattern of gastric cancer mortality in Spain: environmental hypotheses revisited

Open Access
Research article

Nuria Aragonés, Beatriz Pérez-Gómez, Marina Pollán, Rebeca Ramis, Enrique Vidal, Virginia Lope, Javier García-Pérez, Elena Boldo, Gonzalo López-Abente

Gene expression down-regulation in CD90+prostate tumor-associated stromal cells involves potential organ-specific genes

Open Access
Research article

Laura E Pascal, Young Ah Goo, Ricardo ZN Vêncio, Laura S Page, Amber A Chambers, Emily S Liebeskind, Thomas K Takayama, Lawrence D True, Alvin Y Liu

Par-3 partitioning defective 3 homolog (C. elegans) and androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cells

Open Access
Research article

Dimiter Kunnev, Igor Ivanov, Yurij Ionov

Cancer Health Empowerment for Living without Pain (Ca-HELP): study design and rationale for a tailored education and coaching intervention to enhance care of cancer-related pain

Open Access
Study protocol

Richard L Kravitz, Daniel J Tancredi, Richard L Street Jr, Donna Kalauokalani, Tim Grennan, Ted Wun, Christina Slee, Dionne Evans Dean, Linda Lewis, Naomi Saito, Peter Franks

Differential expression of follistatin and FLRG in human breast proliferative disorders

Open Access
Research article

Enrrico Bloise, Henrique L Couto, Lauretta Massai, Pasquapina Ciarmela, Marzia Mencarelli, Lavinia E Borges, Michela Muscettola, Giovanni Grasso, Vania F Amaral, Geovanni D Cassali, Felice Petraglia, Fernando M Reis

Identification of Achaete-scute complex-like 1 (ASCL1) target genes and evaluation of DKK1 and TPH1 expression in pancreatic endocrine tumours

Open Access
Research article

Térèse A Johansson, Gunnar Westin, Britt Skogseid

Tumor tissue levels of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and outcome following adjuvant chemotherapy in premenopausal lymph node-positive breast cancer patients: A retrospective study

Open Access
Research article

Anne-Sofie Schrohl, Maxime P Look, Marion E Meijer-van Gelder, John A Foekens, Nils Brünner

Overexpression of human sperm protein 17 increases migration and decreases the chemosensitivity of human epithelial ovarian cancer cells

Open Access
Research article

Fang-qiu Li, Yan-ling Han, Qun Liu, Bo Wu, Wen-bin Huang, Su-yun Zeng

CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection

Open Access
Research article

Chau-Ting Yeh, Chia-Jung Kuo, Ming-Wei Lai, Tse-Ching Chen, Chun-Yen Lin, Ta-Sen Yeh, Wei-Chen Lee

Expression analysis of E-cadherin, Slug and GSK3β in invasive ductal carcinoma of breast

Open Access
Research article

Chandra P Prasad, Gayatri Rath, Sandeep Mathur, Dinesh Bhatnagar, Rajinder Parshad, Ranju Ralhan

Effectiveness of early detection on breast cancer mortality reduction in Catalonia (Spain)

Open Access
Research article

Montserrat Rue, Ester Vilaprinyo, Sandra Lee, Montserrat Martinez-Alonso, Misericordia Carles, Rafael Marcos-Gragera, Roger Pla, Josep-Alfons Espinas

Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia

Open Access
Research article

Mark M Aloysius, Abed M Zaitoun, Timothy E Bates, Abdulkader Albasri, Mohammad Ilyas, Brian J Rowlands, Dileep N Lobo

Impact of sex, MHC, and age of recipients on the therapeutic effect of transferred leukocytes from cancer-resistant SR/CR mice

Open Access
Research article

John R Stehle Jr, Michael J Blanks, Gregory Riedlinger, Jung W Kim-Shapiro, Anne M Sanders, Jonathan M Adams, Mark C Willingham, Zheng Cui

Transcription factor AP-1 in esophageal squamous cell carcinoma: Alterations in activity and expression during Human Papillomavirus infection

Open Access
Research article

Showket Hussain, Alok C Bharti, Irfana Salam, Mohammad Akbar Bhat, Mohammad Muzaffar Mir, Suresh Hedau, Mushtaq A Siddiqi, Seemi Farhat Basir, Bhudev C Das

Expression of oestrogen receptors, ERα, ERβ, and ERβ variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERα

Open Access
Research article

Frances Collins, Sheila MacPherson, Pamela Brown, Vincent Bombail, Alistair RW Williams, Richard A Anderson, Henry N Jabbour, Philippa TK Saunders

Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility

Open Access
Research article

Szu-Min Hsieh, Robert A Smith, Nicholas A Lintell, Kent W Hunter, Lyn R Griffiths

A study protocol to investigate the relationship between dietary fibre intake and fermentation, colon cell turnover, global protein acetylation and early carcinogenesis: the FACT study

Open Access
Study protocol

Bernard M Corfe, Elizabeth A Williams, Jonathan P Bury, Stuart A Riley, Lisa J Croucher, Daphne YL Lai, Caroline A Evans

Response to gefitinib and erlotinib in Non-small cell lung cancer: a retrospective study

Open Access
Research article

Ivette F Emery, Chiara Battelli, Paul L Auclair, Kathleen Carrier, Daniel M Hayes

Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10cells - the involvement of rapidly activated kinases and caspases

Open Access
Research article

Yow-Jiun Jeng, Cheryl S Watson

Early detection of breast cancer: benefits and risks of supplemental breast ultrasound in asymptomatic women with mammographically dense breast tissue. A systematic review

Open Access
Research article

Monika Nothacker, Volker Duda, Markus Hahn, Mathias Warm, Friedrich Degenhardt, Helmut Madjar, Susanne Weinbrenner, Ute-Susann Albert

External validation suggests Integrin beta 3 as prognostic biomarker in serous ovarian adenocarcinomas

Open Access
Research article

Karolina Partheen, Kristina Levan, Lovisa Österberg, Ingela Claesson, Karin Sundfeldt, György Horvath

The interaction of HAb18G/CD147 with integrin α6β1 and its implications for the invasion potential of human hepatoma cells

Open Access
Research article

Jing-yao Dai, Ke-feng Dou, Cong-hua Wang, Pu Zhao, Wayne Bond Lau, Ling Tao, Ya-mei Wu, Juan Tang, Jian-li Jiang, Zhi-nan Chen

Salvage therapy of pretreated advanced breast cancer with bevacizumab and paclitaxel every two weeks: a retrospective case review study

Open Access
Research article

Alexandros Ardavanis, Dimitrios Doufexis, Panteleimon Kountourakis, Savvoula Malliou, Athanasios Karagiannis, Evgenia Kardara, Despina Sykoutri, Margari Charalampia, Gerasimos Rigatos

Topoisomerase I but not thymidylate synthase is associated with improved outcome in patients with resected colorectal cancer treated with irinotecan containing adjuvant chemotherapy

Open Access
Research article

Ioannis Kostopoulos, Vasilios Karavasilis, Maria Karina, Mattheos Bobos, Nikolaos Xiros, George Pentheroudakis, Georgia Kafiri, Pavlos Papakostas, Eleni Vrettou, George Fountzilas

Ovarian cancer survival population differences: a "high resolution study" comparing Philippine residents, and Filipino-Americans and Caucasians living in the US

Open Access
Research article

Maria Theresa M Redaniel, Adriano Laudico, Maria Rica Mirasol-Lumague, Adam Gondos, Gemma Leonora Uy, Jean Ann Toral, Doris Benavides, Hermann Brenner

The accuracy of frozen section analysis in ultrasound- guided core needle biopsy of breast lesions

Open Access
Research article

Andreas H Brunner, Thomas Sagmeister, Jolanta Kremer, Paul Riss, Hermann Brustmann

Site-specific relapse pattern of the triple negative tumors in Chinese breast cancer patients

Open Access
Research article

Yanping Lin, Wenjin Yin, Tingting Yan, Liheng Zhou, Genhong Di, Jiong Wu, Zhenzhou Shen, Zhimin Shao, Jinsong Lu

The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma

Open Access
Research article

Di He, Qin Xu, Ming Yan, Ping Zhang, Xiaojian Zhou, Zhiyuan Zhang, Wenhu Duan, Laiping Zhong, Dongxia Ye, Wantao Chen

Association of common variants in mismatch repair genes and breast cancer susceptibility: a multigene study

Open Access
Research article

João Conde, Susana N Silva, Ana P Azevedo, Valdemar Teixeira, Julieta Esperança Pina, José Rueff, Jorge F Gaspar

Adjuvant concurrent chemoradiation therapy (CCRT) alone versus CCRT followed by adjuvant chemotherapy: Which is better in patients with radically resected extrahepatic biliary tract cancer?: a non-randomized, single center study

Open Access
Research article

Kyu-Hyoung Lim, Do-Youn Oh, Eui Kyu Chie, Jin-Young Jang, Seock-Ah Im, Tae-You Kim, Sun-Whe Kim, Sung Whan Ha, Yung-Jue Bang

Gastric cancer mortality trends in Spain, 1976-2005, differences by autonomous region and sex

Open Access
Research article

Esther García-Esquinas, Beatriz Pérez-Gómez, Marina Pollán, Elena Boldo, Pablo Fernández-Navarro, Virginia Lope, Enrique Vidal, Gonzalo López-Abente, Nuria Aragonés

Bevacizumab plus FOLFIRI or FOLFOX in chemotherapy-refractory patients with metastatic colorectal cancer: a retrospective study

Open Access
Research article

Astrid Lièvre, Emmanuelle Samalin, Emmanuel Mitry, Eric Assenat, Christine Boyer-Gestin, Céline Lepère, Jean-Baptiste Bachet, Fabienne Portales, Jean-Nicolas Vaillant, Marc Ychou, Philippe Rougier

Noninvasive detection of lung cancer by analysis of exhaled breath

Open Access
Research article

Amel Bajtarevic, Clemens Ager, Martin Pienz, Martin Klieber, Konrad Schwarz, Magdalena Ligor, Tomasz Ligor, Wojciech Filipiak, Hubert Denz, Michael Fiegl, Wolfgang Hilbe, Wolfgang Weiss, Peter Lukas, Herbert Jamnig, Martin Hackl, Alfred Haidenberger, Bogusław Buszewski, Wolfram Miekisch, Jochen Schubert, Anton Amann

Intensity and timing of physical activity in relation to postmenopausal breast cancer risk: the prospective NIH-AARP Diet and Health Study

Open Access
Research article

Tricia M Peters, Steven C Moore, Gretchen L Gierach, Nicholas J Wareham, Ulf Ekelund, Albert R Hollenbeck, Arthur Schatzkin, Michael F Leitzmann

Tumor suppressor protein SMAR1 modulates the roughness of cell surface: combined AFM and SEM study

Open Access
Research article

Ruchika Kaul-Ghanekar, Sandeep Singh, Hitesh Mamgain, Archana Jalota-Badhwar, Kishore M Paknikar, Samit Chattopadhyay

Anti-HER2 IgY antibody-functionalized single-walled carbon nanotubes for detection and selective destruction of breast cancer cells

Open Access
Research article

Yan Xiao, Xiugong Gao, Oleh Taratula, Stephen Treado, Aaron Urbas, R David Holbrook, Richard E Cavicchi, C Thomas Avedisian, Somenath Mitra, Ronak Savla, Paul D Wagner, Sudhir Srivastava, Huixin He

Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy

Open Access
Research article

Milena Casula, Antonio Muggiano, Antonio Cossu, Mario Budroni, Corrado Caracò, Paolo A Ascierto, Elena Pagani, Ignazio Stanganelli, Sergio Canzanella, MariaCristina Sini, Grazia Palomba, Giuseppe Palmieri

miRNAs in lung cancer - Studying complex fingerprints in patient's blood cells by microarray experiments

Open Access
Research article

Andreas Keller, Petra Leidinger, Anne Borries, Anke Wendschlag, Frank Wucherpfennig, Matthias Scheffler, Hanno Huwer, Hans-Peter Lenhof, Eckart Meese

Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation

Open Access
Research article

Emanuela Taioli, Camille Ragin, Xiao-hong Wang, Jiangying Chen, Scott M Langevin, Ashley R Brown, Susanne M Gollin, Seymour Garte, Robert W Sobol

FRAGMATIC: A randomised phase III clinical trial investigating the effect of fragmin® added to standard therapy in patients with lung cancer

Open Access
Study protocol

Gareth O Griffiths, Sarah Burns, Simon I Noble, Fergus R Macbeth, David Cohen, Timothy S Maughan

The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors

Open Access
Research article

Krupa J Patel, Ian F Tannock

ST3Gal.I sialyltransferase relevance in bladder cancer tissues and cell lines

Open Access
Research article

Paula A Videira, Manuela Correia, Nadia Malagolini, Hélio J Crespo, Dário Ligeiro, Fernando M Calais, Helder Trindade, Fabio Dall'Olio

Ability of Group IVB metallocene polyethers containing dienestrol to arrest the growth of selected cancer cell lines

Open Access
Research article

Michael R Roner, Charles E Carraher Jr, Kimberly Shahi, Yuki Ashida, Girish Barot

DNA damage induced by cis- and carboplatin as indicator for in vitro sensitivity of ovarian carcinoma cells

Open Access
Research article

Florian T Unger, Hermann A Klasen, Garri Tchartchian, Rudy L de Wilde, Irene Witte

Selecting for BRCA1 testing using a combination of homogeneous selection criteria and immunohistochemical characteristics of breast cancers

Open Access
Research article

GianMaria Miolo, Vincenzo Canzonieri, Clelia De Giacomi, Lara Della Puppa, Riccardo Dolcetti, Davide Lombardi, Tiziana Perin, Simona Scalone, Andrea Veronesi, Alessandra Viel

Combination of interferon-alpha and 5-fluorouracil inhibits endothelial cell growth directly and by regulation of angiogenic factors released by tumor cells

Open Access
Research article

Hiroshi Wada, Hiroaki Nagano, Hirofumi Yamamoto, Takehiro Noda, Masahiro Murakami, Shogo Kobayashi, Shigeru Marubashi, Hidetoshi Eguchi, Yutaka Takeda, Masahiro Tanemura, Koji Umeshita, Yuichiro Doki, Masaki Mori

Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors

Open Access
Research article

Johanna Tuomela, Maija Valta, Jani Seppänen, Kati Tarkkonen, H Kalervo Väänänen, Pirkko Härkönen

Establishment of canine hemangiosarcoma xenograft models expressing endothelial growth factors, their receptors, and angiogenesis-associated homeobox genes

Open Access
Research article

Atsushi Kodama, Hiroki Sakai, Satoko Matsuura, Mami Murakami, Atsuko Murai, Takashi Mori, Kouji Maruo, Tohru Kimura, Toshiaki Masegi, Tokuma Yanai

Socioeconomic disparities in breast cancer survival: relation to stage at diagnosis, treatment and race

Open Access
Research article

Xue Qin Yu

A 7 gene expression score predicts for radiation response in cancer cervix

Open Access
Research article

Thangarajan Rajkumar, Neelakantan Vijayalakshmi, Kesavan Sabitha, Sundersingh Shirley, Ganesharaja Selvaluxmy, Mayil Vahanan Bose, Lavanya Nambaru

Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells

Open Access
Research article

Haiyu Li, Zhenggang Ren, Xiaonan Kang, Lan Zhang, Xuefei Li, Yan Wang, Tongchun Xue, Yuefang Shen, Yinkun Liu

Predicting for activity of second-line trastuzumab-based therapy in her2-positive advanced breast cancer

Open Access
Research article

Rupert Bartsch, Catharina De Vries, Ursula Pluschnig, Peter Dubsky, Zsuzsanna Bago-Horvath, Simon P Gampenrieder, Margaretha Rudas, Robert M Mader, Andrea Rottenfusser, Christoph Wiltschke, Michael Gnant, Christoph C Zielinski, Guenther G Steger

Potential predictive markers of chemotherapy resistance in stage III ovarian serous carcinomas

Open Access
Research article

Lovisa Österberg, Kristina Levan, Karolina Partheen, Ulla Delle, Björn Olsson, Karin Sundfeldt, György Horvath

Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis

Open Access
Research article

Patricia J McLaughlin, Ian S Zagon, Sunny S Park, Andrea Conway, Renee N Donahue, David Goldenberg

Clinical relevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinse

Open Access
Research article

Benjamin Lallemant, Alexandre Evrard, Christophe Combescure, Heliette Chapuis, Guillaume Chambon, Caroline Raynal, Christophe Reynaud, Omar Sabra, Dominique Joubert, Frédéric Hollande, Jean-Gabriel Lallemant, Serge Lumbroso, Jean-Paul Brouillet

NK-like homeodomain proteins activate NOTCH3-signaling in leukemic T-cells

Open Access
Research article

Stefan Nagel, Letizia Venturini, Grzegorz K Przybylski, Piotr Grabarczyk, Corinna Meyer, Maren Kaufmann, Karin Battmer, Christian A Schmidt, Hans G Drexler, Michaela Scherr, Roderick AF MacLeod

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults

Open Access
Research article

Pierre A Robe, Didier H Martin, Minh T Nguyen-Khac, Maria Artesi, Manuel Deprez, Adelin Albert, Sophie Vanbelle, Stephane Califice, Markus Bredel, Vincent Bours

The incidence and risk of developing a second primary esophageal cancer in patients with oral and pharyngeal carcinoma: a population-based study in Taiwan over a 25 year period

Open Access
Research article

Kuan-Der Lee, Chang-Hsien Lu, Ping-Tsung Chen, Chunghuang Hubert Chan, Jen-Tsun Lin, Cih-En Huang, Chih-Cheng Chen, Min-Chi Chen

Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer

Open Access
Research article

Greg M Arndt, Lesley Dossey, Lara M Cullen, Angela Lai, Riki Druker, Michael Eisbacher, Chunyan Zhang, Nham Tran, Hongtao Fan, Kathy Retzlaff, Anton Bittner, Mitch Raponi

Retrospective analysis of 119 Chinese noninflammatory locally advanced breast cancer cases treated with intravenous combination of vinorelbine and epirubicin as a neoadjuvant chemotherapy: a median follow-up of 63.4 months

Open Access
Research article

Ou Huang, CanMing Chen, JiaYi Wu, ShuJie Chen, XiaoSong Chen, GuangYu Liu, Zhen Hu, JingSong Lu, Jiong Wu, ZhiMin Shao, ZhenZhou Shen, KunWei Shen

Clinical meaning of age-related expression of fecal cytokeratin 19 in colorectal malignancy

Open Access
Research article

Chun-Chao Chang, Shung-Haur Yang, Chih-Cheng Chien, Shu-Hung Chen, Shiann Pan, Chia-Long Lee, Chih-Ming Lin, Hsiao-Lun Sun, Chi-Cheng Huang, Yih-Yiing Wu, Ruey-Neng Yang, Chi-Jung Huang

Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT)

Open Access
Research article

Li-Mei Chen, Nicole J Verity, Karl X Chai

Expression profiling identifies genes involved in neoplastic transformation of serous ovarian cancer

Open Access
Research article

Melissa A Merritt, Peter G Parsons, Tanya R Newton, Adam C Martyn, Penelope M Webb, Adèle C Green, David J Papadimos, Glen M Boyle

Association between an 8q24 locus and the risk of colorectal cancer in Japanese

Open Access
Research article

Keitaro Matsuo, Takeshi Suzuki, Hidemi Ito, Satoyo Hosono, Takakazu Kawase, Miki Watanabe, Kohei Shitara, Koji Komori, Yukihide Kanemitsu, Takashi Hirai, Yasushi Yatabe, Hideo Tanaka, Kazuo Tajima

TRPV6 alleles do not influence prostate cancer progression

Open Access
Research article

Thorsten Kessler, Ulrich Wissenbach, Rainer Grobholz, Veit Flockerzi

Comparison of breast cancer survival in two populations: Ardabil, Iran and British Columbia, Canada

Open Access
Research article

Alireza Sadjadi, T Gregory Hislop, Chris Bajdik, Morteza Bashash, Anahita Ghorbani, Mehdi Nouraie, Masoud Babaei, Reza Malekzadeh, Parvin Yavari

Assessing pathogenicity of MLH1 variants by co-expression of human MLH1 and PMS2genes in yeast

Open Access
Research article

Matjaz Vogelsang, Aleksandra Comino, Neja Zupanec, Petra Hudler, Radovan Komel

Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting

Open Access
Research article

Grace E Snow, Allison C Kasper, Alexander M Busch, Elisabeth Schwarz, Katherine E Ewings, Thomas Bee, Michael J Spinella, Ethan Dmitrovsky, Sarah J Freemantle

Cooperation of decay-accelerating factor and membrane cofactor protein in regulating survival of human cervical cancer cells

Open Access
Research article

Ling-Juan Gao, Shu-Yu Guo, You-Qun Cai, Ping-Qing Gu, Ya-Juan Su, Hui Gong, Yun Liu, Chen Chen

High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression

Open Access
Research article

Frederikke Lihme Egerod, Annette Bartels, Niels Fristrup, Michael Borre, Torben F Ørntoft, Martin B Oleksiewicz, Nils Brünner, Lars Dyrskjøt

The mannosylated extracellular domain of Her2/neu produced in P. pastorisinduces protective antitumor immunity

Open Access
Research article

Alexios Dimitriadis, Chrysanthi Gontinou, Constantin N Baxevanis, Avgi Mamalaki

Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations

Open Access
Research article

Ana Preto, Joana Gonçalves, Ana P Rebocho, Joana Figueiredo, Ana M Meireles, Ana S Rocha, Helena M Vasconcelos, Hugo Seca, Raquel Seruca, Paula Soares, Manuel Sobrinho-Simões

Continuous 5-fluorouracil infusion plus long acting octreotide in advanced well-differentiated neuroendocrine carcinomas. A phase II trial of the Piemonte Oncology Network

Open Access
Research article

Maria P Brizzi, Alfredo Berruti, Anna Ferrero, Enrica Milanesi, Marco Volante, Federico Castiglione, Nadia Birocco, Sebastiano Bombaci, Davide Perroni, Benedetta Ferretti, Oscar Alabiso, Libero Ciuffreda, Oscar Bertetto, Mauro Papotti, Luigi Dogliotti

Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parameters

Open Access
Research article

Ke Hao, John M Luk, Nikki PY Lee, Mao Mao, Chunsheng Zhang, Mark D Ferguson, John Lamb, Hongyue Dai, Irene O Ng, Pak C Sham, Ronnie TP Poon

Circulating levels of matrix metalloproteinase-9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and their complex MMP-9/NGAL in breast cancer disease

Open Access
Research article

Xeni Provatopoulou, Antonia Gounaris, Eleni Kalogera, Flora Zagouri, Ioannis Flessas, Evgenios Goussetis, Afroditi Nonni, Ioannis Papassotiriou, George Zografos

Assessment of angiogenesis by CD105 antigen in epithelial salivary gland neoplasms with diverse metastatic behavior

Open Access
Research article

Sergio V Cardoso, Kelen Christine N Souza, Paulo R Faria, Ana Lucia A Eisenberg, Fernando L Dias, Adriano M Loyola

A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB

Open Access
Research article

Yao Dai, Meilan Liu, Wenhua Tang, Yongming Li, Jiqin Lian, Theodore S Lawrence, Liang Xu

A balanced t(5;17) (p15;q22-23) in chondroblastoma: frequency of the re-arrangement and analysis of the candidate genes

Open Access
Research article

Salvatore Romeo, Karoly Szuhai, Isao Nishimori, Marije Ijszenga, Pauline Wijers-Koster, Antonie HM Taminiau, Pancras CW Hogendoorn

B7-H4gene polymorphisms are associated with sporadic breast cancer in a Chinese Han population

Open Access
Research article

Jie Zhang, Mingyan Zhang, Wei Jiang, Lihong Wang, Zhenkun Fu, Dalin Li, Da Pang, Dianjun Li

High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo

Open Access
Research article

Annika Lehmann, Carsten Denkert, Jan Budczies, Ann-Christin Buckendahl, Silvia Darb-Esfahani, Aurelia Noske, Berit Maria Müller, Marcus Bahra, Peter Neuhaus, Manfred Dietel, Glen Kristiansen, Wilko Weichert

An informatics supported web-based data annotation and query tool to expedite translational research for head and neck malignancies

Open Access
Technical advance

Waqas Amin, Hyunseok P Kang, Ann Marie Egloff, Harpreet Singh, Kerry Trent, Jennifer Ridge-Hetrick, Raja R Seethala, Jennifer Grandis, Anil V Parwani

Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among Men of African Descent: A case-control study

Open Access
Research article

Nicole A Lavender, Marnita L Benford, Tiva T VanCleave, Guy N Brock, Rick A Kittles, Jason H Moore, David W Hein, La Creis R Kidd

DNA-AP sites generation by Etoposide in whole blood cells

Open Access
Research article

Emilio Rojas, Patricia Mussali, Efrain Tovar, Mahara Valverde

Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma

Open Access
Research article

Michiro Susa, Arun K Iyer, Keinosuke Ryu, Francis J Hornicek, Henry Mankin, Mansoor M Amiji, Zhenfeng Duan

XPD codon 312 and 751 polymorphisms, and AFB1 exposure, and hepatocellular carcinoma risk

Open Access
Research article

Xi Dai Long, Yun Ma, Yun Feng Zhou, Jin Guang Yao, Fu Zhi Ban, Yong Zhi Huang, Bing Cheng Huang

Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states

Open Access
Research article

Aaron L Sarver, Amy J French, Pedro M Borralho, Venugopal Thayanithy, Ann L Oberg, Kevin AT Silverstein, Bruce W Morlan, Shaun M Riska, Lisa A Boardman, Julie M Cunningham, Subbaya Subramanian, Liang Wang, Tom C Smyrk, Cecilia MP Rodrigues, Stephen N Thibodeau, Clifford J Steer

Initial activation of EpCAM cleavage viacell-to-cell contact

Open Access
Research article

Sabine Denzel, Dorothea Maetzel, Brigitte Mack, Carola Eggert, Gabriele Bärr, Olivier Gires

Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma

Open Access
Research article

Ahmed S Abdulamir, Rand R Hafidh, Layla K Mahdi, Tarik Al-jeboori, Fatimah Abubaker

The effect of low-level laser irradiation (In-Ga-Al-AsP - 660 nm) on melanoma in vitro and in vivo

Open Access
Research article

Lúcio Frigo, Juliana SS Luppi, Giovani M Favero, Durnavei A Maria, Sócrates C Penna, Jan M Bjordal, Rene J Bensadoun, Rodrigo AB Lopes-Martins

Partial loss of heterozygosity events at the mutated gene in tumors from MLH1/MSH2 large genomic rearrangement carriers

Open Access
Research article

Katarina Zavodna, Tomas Krivulcik, Maria Gerykova Bujalkova, Tomas Slamka, David Martinicky, Denisa Ilencikova, Zdena Bartosova

The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study

Open Access
Research article

Adela Castillejo, Trinidad Mata-Balaguer, Carla Guarinos, María-Isabel Castillejo, Ana Martínez-Cantó, Víctor-Manuel Barberá, Paola Montenegro, Enrique Ochoa, Rafael Lázaro, Carmen Guillén-Ponce, Alfredo Carrato, José-Luís Soto

Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study

Open Access
Research article

Vibeke Andersen, Mette Østergaard, Jane Christensen, Kim Overvad, Anne Tjønneland, Ulla Vogel

Prospective study of daily low-dose nedaplatin and continuous 5-fluorouracil infusion combined with radiation for the treatment of esophageal squamous cell carcinoma

Open Access
Research article

Satoshi Osawa, Takahisa Furuta, Ken Sugimoto, Takashi Kosugi, Tomohiro Terai, Mihoko Yamade, Yasuhiro Takayanagi, Masafumi Nishino, Yasushi Hamaya, Chise Kodaira, Takanori Yamada, Moriya Iwaizumi, Kosuke Takagaki, Ken-ichi Yoshida, Shigeru Kanaoka, Mutsuhiro Ikuma

Impact of biospecimens handling on biomarker research in breast cancer

Open Access
Research article

Loris De Cecco, Valeria Musella, Silvia Veneroni, Vera Cappelletti, Italia Bongarzone, Maurizio Callari, Barbara Valeri, Marco A Pierotti, Maria Grazia Daidone

Nuclear detection of Y-boxprotein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancer

Open Access
Research article

Edgar Dahl, Abdelaziz En-Nia, Frank Wiesmann, Renate Krings, Sonja Djudjaj, Elisabeth Breuer, Thomas Fuchs, Peter J Wild, Arndt Hartmann, Sandra E Dunn, Peter R Mertens

PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells

Open Access
Research article

Hal E Crosswell, Anindya Dasgupta, Carlos S Alvarado, Tanya Watt, James G Christensen, Pradip De, Donald L Durden, Harry W Findley

An open label randomized multicentre phase IIIb trial comparing parenteral substitution versus best supportive nutritional care in subjects with pancreatic adenocarcinoma receiving 5-FU plus oxaliplatin as 2ndor higher line chemotherapy regarding clinical benefit - PANUSCO

Open Access
Study protocol

Angela Märten, Moritz N Wente, Jennifer Ose, Markus W Büchler, Ingeborg Rötzer, Christiane Decker-Baumann, Irini Karapanagiotou-Schenkel, Sabine Harig, Jan Schmidt, Dirk Jäger

Functional features of gene expression profiles differentiating gastrointestinal stromal tumours according to KITmutations and expression

Open Access
Research article

Jerzy Ostrowski, Marcin Polkowski, Agnieszka Paziewska, Magdalena Skrzypczak, Krzysztof Goryca, Tymon Rubel, Katarzyna Kokoszyñska, Piotr Rutkowski, Zbigniew I Nowecki, Anna Jerzak Vel Dobosz, Dorota Jarosz, Wlodzimierz Ruka, Lucjan S Wyrwicz

Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells

Open Access
Research article

Rizky Abdulah, Ahmad Faried, Kenji Kobayashi, Chiho Yamazaki, Eka W Suradji, Kazuto Ito, Kazuhiro Suzuki, Masami Murakami, Hiroyuki Kuwano, Hiroshi Koyama

A novel asymmetric 3D in-vitro assay for the study of tumor cell invasion

Open Access
Technical advance

Vera Brekhman, Gera Neufeld

Expression of indoleamine 2,3-dioxygenase in nasopharyngeal carcinoma impairs the cytolytic function of peripheral blood lymphocytes

Open Access
Research article

Peng Liu, Bai-Lu Xie, Shao-Hui Cai, Yun-Wen He, Ge Zhang, Yan-Mei Yi, Jun Du

Characterization of TEM1/endosialinin human and murine brain tumors

Open Access
Research article

Eleanor B Carson-Walter, Bethany N Winans, Melissa C Whiteman, Yang Liu, Sally Jarvela, Hannu Haapasalo, Betty M Tyler, David L Huso, Mahlon D Johnson, Kevin A Walter

Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery

Open Access
Research article

Chen-Xin Dai, Qiang Gao, Shuang-Jian Qiu, Min-Jie Ju, Ming-Yan Cai, Yong-Feng Xu, Jian Zhou, Bo-Heng Zhang, Jia Fan

A randomized controlled trial of an exercise intervention targeting cardiovascular and metabolic risk factors for prostate cancer patients from the RADAR trial

Open Access
Study protocol

Daniel A Galvão, Nigel Spry, Dennis R Taaffe, James Denham, David Joseph, David S Lamb, Greg Levin, Gillian Duchesne, Robert U Newton

Identification of colorectal cancer patients with tumors carrying the TP53mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy

Open Access
Research article

Ten-i Godai, Tetsuji Suda, Nobuhiro Sugano, Kazuhito Tsuchida, Manabu Shiozawa, Hironobu Sekiguchi, Akiko Sekiyama, Mitsuyo Yoshihara, Shoichi Matsukuma, Yuji Sakuma, Eiju Tsuchiya, Yoichi Kameda, Makoto Akaike, Yohei Miyagi

Efficacy of plasma vascular endothelial growth factor in monitoring first-line chemotherapy in patients with advanced non-small cell lung cancer

Open Access
Research article

Sachin Kumar, Randeep Guleria, Vikas Singh, Alok C Bharti, Anant Mohan, Bhudev C Das

Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression

Open Access
Research article

Carine Nyalendo, Hervé Sartelet, Stéphane Barrette, Shigeru Ohta, Denis Gingras, Richard Béliveau

Signalling with retinoids in the human lung: validation of new tools for the expression study of retinoid receptors

Open Access
Research article

Stéphane Poulain, Stéphanie Lacomme, Shyue-Fang Battaglia-Hsu, Stanislas du Manoir, Lydia Brochin, Jean-Michel Vignaud, Nadine Martinet

Long term survival following the detection of circulating tumour cells in head and neck squamous cell carcinoma

Open Access
Research article

Stuart C Winter, Sally-Anne Stephenson, Selva K Subramaniam, Vinidh Paleri, Kien Ha, Conor Marnane, Suren Krishnan, Guy Rees

Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinomas

Open Access
Research article

Ove Bruland, Øystein Fluge, Lars A Akslen, Hans G Eiken, Johan R Lillehaug, Jan E Varhaug, Per M Knappskog

Expression of HIWI in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis

Open Access
Research article

Wei He, Zhihui Wang, Qi Wang, Qingxia Fan, Chengcao Shou, Junsheng Wang, Karl-Erik Giercksky, Jahn M Nesland, Zhenhe Suo

Expression of RECK and matrix metalloproteinase-2 in ameloblastoma

Open Access
Research article

Bin Zhang, Jin Zhang, Zhi-Ying Xu, Hong-Liang Xie

Gastric cancer surgery: Billroth I or Billroth II for distal gastrectomy?

Open Access
Research article

Birendra K Sah, Ming-Min Chen, Min Yan, Zheng-Gang Zhu

Cadmium burden and the risk and phenotype of prostate cancer

Open Access
Research article

Yi-Chun Chen, Yeong S Pu, Hsi-Chin Wu, Tony T Wu, Ming Kuen Lai, Chun Y Yang, Fung-Chang Sung

Overexpression of inhibitor of DNA-binding (ID)-1 protein related to angiogenesis in tumor advancement of ovarian cancers

Open Access
Research article

Min Khine Maw, Jiro Fujimoto, Teruhiko Tamaya

Synthesis and expression of CDw75 antigen in human colorectal cancer

Open Access
Research article

Clotilde Costa-Nogueira, Susana Villar-Portela, Elisa Cuevas, Emilio Gil-Martín, Almudena Fernández-Briera

Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications

Open Access
Research article

Dan Cao, Mei Hou, Yong-song Guan, Ming Jiang, Yu Yang, Hong-feng Gou

HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy

Open Access
Research article

Jessica N McAlpine, Kimberly C Wiegand, Russell Vang, Brigitte M Ronnett, Anna Adamiak, Martin Köbel, Steve E Kalloger, Kenneth D Swenerton, David G Huntsman, C Blake Gilks, Dianne M Miller

APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profiling

Open Access
Research article

Russell D Petty, Leslie M Samuel, Graeme I Murray, Graham MacDonald, Terrence O'Kelly, Malcolm Loudon, Norman Binnie, Emad Aly, Aileen McKinlay, Weiguang Wang, Fiona Gilbert, Scot Semple, Elaina SR Collie-Duguid

Aurora-A overexpression enhances cell-aggregation of Ha-rastransformants through the MEK/ERK signaling pathway

Open Access
Research article

Ya-Shih Tseng, Jenq-Chang Lee, Chi-Ying F Huang, Hsiao-Sheng Liu

c.1810C>T Polymorphism of NTRK1Gene is associated with reduced Survival in Neuroblastoma Patients

Open Access
Research article

Beata S Lipska, Elżbieta Drożynska, Paola Scaruffi, Gian Paolo Tonini, Ewa Iżycka-Świeszewska, Szymon Ziętkiewicz, Anna Balcerska, Danuta Perek, Alicja Chybicka, Wojciech Biernat, Janusz Limon

Rapid detection of SMARCB1 sequence variation using high resolution melting

Open Access
Research article

Vinod Dagar, Chung-Wo Chow, David M Ashley, Elizabeth M Algar

Nuclear receptor coregulator SNP discovery and impact on breast cancer risk

Open Access
Research article

Ryan J Hartmaier, Sandrine Tchatchou, Alexandra S Richter, Jay Wang, Sean E McGuire, Todd C Skaar, Jimmy M Rae, Kari Hemminki, Christian Sutter, Nina Ditsch, Peter Bugert, Bernhard HF Weber, Dieter Niederacher, Norbert Arnold, Raymonda Varon-Mateeva, Barbara Wappenschmidt, Rita K Schmutzler, Alfons Meindl, Claus R Bartram, Barbara Burwinkel, Steffi Oesterreich

Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma

Open Access
Research article

Zhihua Yin, Baosen Zhou, Qincheng He, Mingchuan Li, Peng Guan, Xuelian Li, Zeshi Cui, Xiaoxia Xue, Meng Su, Rui Ma, Weijun Bai, Shuyue Xia, Yanduo Jiang, Shun Xu, Yi Lv, Xun Li

Sensitive HPV detection in oropharyngeal cancers

Open Access
Research article

David M Winder, Siolian LR Ball, Katie Vaughan, Nashat Hanna, Yin Ling Woo, Jürgen-Theodor Fränzer, Jane C Sterling, Margaret A Stanley, Holger Sudhoff, Peter KC Goon

Transcribed-ultra conserved region expression is associated with outcome in high-risk neuroblastoma

Open Access
Research article

Paola Scaruffi, Sara Stigliani, Stefano Moretti, Simona Coco, Carla De Vecchi, Francesca Valdora, Alberto Garaventa, Stefano Bonassi, Gian Paolo Tonini

ATP stimulates chemokine production via a store-operated calcium entry pathway in C6 glioma cells

Open Access
Research article

Nattinee Jantaratnotai, Hyun B Choi, James G McLarnon

Risk of urinary bladder cancer: a case-control analysis of industry and occupation

Open Access
Research article

Adrian Cassidy, Wei Wang, Xifeng Wu, Jie Lin

Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme

Open Access
Debate

Joost JC Verhoeff, Olaf van Tellingen, An Claes, Lukas JA Stalpers, Myra E van Linde, Dirk J Richel, William PJ Leenders, Wouter R van Furth

Upstream ORF affects MYCN translation depending on exon 1b alternative splicing

Open Access
Research article

Roger Besançon, Sandrine Valsesia-Wittmann, Clara Locher, Céline Delloye-Bourgeois, Lydie Furhman, Giovani Tutrone, Christophe Bertrand, Anne-Catherine Jallas, Elisabeth Garin, Alain Puisieux

Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma

Open Access
Research article

Ingrid Moen, Karl J Tronstad, Odd Kolmannskog, Gerd S Salvesen, Rolf K Reed, Linda EB Stuhr

ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma

Open Access
Research article

Silke Götze, Valeska Feldhaus, Thilo Traska, Marietta Wolter, Guido Reifenberger, Andrea Tannapfel, Cornelius Kuhnen, Dirk Martin, Oliver Müller, Sonja Sievers

Primary ciliogenesis defects are associated with human astrocytoma/glioblastoma cells

Open Access
Research article

Joanna J Moser, Marvin J Fritzler, Jerome B Rattner

Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase-8-dependent pathway in HL-60 human leukemia cells

Open Access
Research article

Sung-Hee Cho, Kyung-Sook Chung, Jung-Hye Choi, Dong-Hyun Kim, Kyung-Tae Lee

Recursive partitioning analysis of prognostic factors in WHO grade III glioma patients treated with radiotherapy or radiotherapy plus chemotherapy

Open Access
Research article

Chul-Kee Park, Se-Hoon Lee, Jung Ho Han, Chae-Yong Kim, Dong-Wan Kim, Sun Ha Paek, Dong Gyu Kim, Dae Seog Heo, Il Han Kim, Hee-Won Jung

Survival of cancer patients treated with mistletoe extract (Iscador): a systematic literature review

Open Access
Research article

Thomas Ostermann, Christa Raak, Arndt Büssing

Gene expression relationship between prostate cancer cells of Gleason 3, 4 and normal epithelial cells as revealed by cell type-specific transcriptomes

Open Access
Research article

Laura E Pascal, Ricardo ZN Vêncio, Laura S Page, Emily S Liebeskind, Christina P Shadle, Pamela Troisch, Bruz Marzolf, Lawrence D True, Leroy E Hood, Alvin Y Liu

Quality assessment of DNA derived from up to 30 years old formalin fixed paraffin embedded (FFPE) tissue for PCR-based methylation analysis using SMART-MSP and MS-HRM

Open Access
Research article

Lasse S Kristensen, Tomasz K Wojdacz, Britta B Thestrup, Carsten Wiuf, Henrik Hager, Lise Lotte Hansen

Decreased mitochondrial DNA content in blood samples of patients with stage I breast cancer

Open Access
Research article

Peng Xia, Han-Xiang An, Cheng-Xue Dang, Ramin Radpour, Corina Kohler, Emmanouil Fokas, Rita Engenhart-Cabillic, Wolfgang Holzgreve, Xiao Yan Zhong

Array-based DNA methylation profiling of primary lymphomas of the central nervous system

Open Access
Research article

Julia Richter, Ole Ammerpohl, José I Martín-Subero, Manuel Montesinos-Rongen, Marina Bibikova, Eliza Wickham-Garcia, Otmar D Wiestler, Martina Deckert, Reiner Siebert

The effect of proteoglycans inhibited by RNA interference on metastatic characters of human salivary adenoid cystic carcinoma

Open Access
Research article

Hong Shi, Jie Wang, Fusheng Dong, Xu Wang, Hexiang Li, Yali Hou

Mutation analysis of the AATF gene in breast cancer families

Open Access
Research article

Maria Haanpää, Mervi Reiman, Jenni Nikkilä, Hannele Erkko, Katri Pylkäs, Robert Winqvist

Pre-radiotherapy plasma carotenoids and markers of oxidative stress are associated with survival in head and neck squamous cell carcinoma patients: a prospective study

Open Access
Research article

Amrit K Sakhi, Kjell M Russnes, Magne Thoresen, Nasser E Bastani, Anette Karlsen, Sigbjørn Smeland, Rune Blomhoff

Thrombosis of abdominal aorta during cisplatin-based chemotherapy of testicular seminoma - a case report

Open Access
Case report

Klaus-Peter Dieckmann, Ralf Gehrckens

The presence of postmenopausal bleeding as prognostic parameter in patients with endometrial cancer: a retrospective multi-center study

Open Access
Research article

Veronika Seebacher, Maximilian Schmid, Stephan Polterauer, Katrin Hefler-Frischmuth, Heinz Leipold, Nicole Concin, Alexander Reinthaller, Lukas Hefler

Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma

Open Access
Research article

Li-Ru He, Meng-Zhong Liu, Bin-Kui Li, Hui-Lan Rao, Yi-Ji Liao, Xin-Yuan Guan, Yi-Xin Zeng, Dan Xie

Gain in cellular organization of inflammatory breast cancer: A 3D in vitro model that mimics the in vivo metastasis

Open Access
Research article

Jorge Morales, Mary L Alpaugh

Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer

Open Access
Research article

Martin Loos, Dennis M Hedderich, Malte Ottenhausen, Nathalia A Giese, Melanie Laschinger, Irene Esposito, Jörg Kleeff, Helmut Friess

Restoration of contact inhibition in human glioblastoma cell lines after MIF knockdown

Open Access
Research article

Jörg Schrader, Oliver Deuster, Birgit Rinn, Martina Schulz, Andreas Kautz, Richard Dodel, Bernhard Meyer, Yousef Al-Abed, Karthikeyan Balakrishnan, Jens P Reese, Michael Bacher

A reproducible brain tumour model established from human glioblastoma biopsies

Open Access
Research article

Jian Wang, Hrvoje Miletic, Per Ø Sakariassen, Peter C Huszthy, Hege Jacobsen, Narve Brekkå, Xingang Li, Peng Zhao, Sverre Mørk, Martha Chekenya, Rolf Bjerkvig, Per Ø Enger

Aktuelle Ausgaben

BMC Cancer 1/2026
BMC Cancer 1/2025
BMC CancerSonderheft 2/2025
The Applications of Bioinformatics in Genome Research
BMC CancerSonderheft 1/2025
The Applications of Bioinformatics in Genome Research
BMC Cancer 1/2024
BMC CancerSonderheft 1/2024
Epacadostat, an IDO1 inhibitor, in combination with pembrolizumab: results from clinical trials in patients with advanced solid tumors
BMC Cancer 1/2023
BMC Cancer 1/2022
BMC Cancer 1/2021
BMC Cancer 1/2020

Scrollen für mehr

Benutzen Sie die Pfeiltasten für mehr

Scrollen oder Pfeiltasten für mehr

Neu im Fachgebiet Onkologie

Adnexläsion zufällig im CT entdeckt? Die Befundung fällt selbst Fachleuten schwer!

06.03.2026
Gynäkologische Radiologie
Nachrichten

Ist eine Läsion benigne oder maligne? Und um welche Art handelt es sich genau? Ergebnisse einer kleinen US-Studie zu inzidentellen CT-Befunden sprechen dafür, dass sich auch Expertinnen und Experten bei Adnex-Auffälligkeiten häufig uneins sind – und einige maligne Läsionen verkennen.

Real-World Daten bestätigen Nivolumab bei Kopf-Hals-Tumoren

06.03.2026
DKK 2026
Kongressbericht

In der nicht-interventionellen Real-World-Studie HANNA wurde Nivolumab bei Menschen mit rezidiviertem oder metastasiertem Plattenepithelkarzinom der Kopf-Hals-Region in verschiedenen Therapielinien geprüft. Ein Kollege präsentierte auf dem diesjährigen Krebskongress in Berlin die finalen Daten.

Wie Mikrobiom und Komedikation Immuntherapien beeinflussen

06.03.2026
DKK 2026
Kongressbericht

Die Effektivität von Checkpoint-Inhibitoren wird unter anderem durch das Mikrobiom und Komedikationen beeinflusst. Wie Ballaststoffe wirken und welche Medikamente man nicht zusammen mit der Immuntherapie geben sollte, zeigten eine Kollegin und ein Kollege auf dem DKK in Berlin auf.

Mehr molekulare Diagnostik bei Krebs ist nicht immer besser

06.03.2026
DKK 2026
Kongressbericht

Neue molekularpathologische Methoden erhöhen die diagnostische Sensitivität bei Tumorerkrankungen. Aber verfeinert ein stetiges Mehr an molekularer Diagnostik auch die therapeutische Präzision? Diese Frage wurde im Rahmen des Deutschen Krebskongresses (DKK) 2026 in Berlin diskutiert.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Bildnachweise

Radiologie-Assistent bereitet Frau für CT vor/© Peakstock/stock.adobe.com (Symbolbild mit Fotomodellen), Plattenepithelkarzinom/© Springer Medizin Verlag GmbH, Frau bereitet Müsli auf Waage zu/© DragonImages / Stock.adobe.com (Symbolbild mit Fotomodell), 3D Illustration einer DNA Sequenzierung/© undefined / Getty Images / iStock