BMC Cancer

Inhalt (697 Artikel)

Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study

Open Access
Research article

Monique M Cherrier, Paul R Borghesani, Amy L Shelton, Celestia S Higano

A multicentric observational trial of pegylated liposomal doxorubicin for metastatic breast cancer

Open Access
Research article

Jens Huober, Werner Fett, Arnd Nusch, Michael Neise, Marcus Schmidt, Arthur Wischnik, Steffen Gerhardt, Thomas Goehler, Hans-Joachim Lück, Andreas Rost

A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates

Open Access
Correspondence

Peter Calabrese, Darryl Shibata

Residual γH2AX foci as an indication of lethal DNA lesions

Open Access
Research article

Judit P Banáth, Dmitry Klokov, Susan H MacPhail, C Adriana Banuelos, Peggy L Olive

Tocotrienols are good adjuvants for developing cancer vaccines

Open Access
Research article

Sitti Rahma Abdul Hafid, Ammu Kutty Radhakrishnan, Kalanithi Nesaretnam

Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors

Open Access
Research article

Deidi Strickland Bergestuen, Jørgen Gravning, Kristina Hermann Haugaa, Laura G Sahakyan, Svend Aakhus, Espen Thiis-Evensen, Erik Øie, Pål Aukrust, Håvard Attramadal, Thor Edvardsen

Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase

Open Access
Research article

Elina Mattila, Heidi Marttila, Niko Sahlberg, Pekka Kohonen, Siri Tähtinen, Pasi Halonen, Merja Perälä, Johanna Ivaska

Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer

Open Access
Research article

Oscar Fernández-Guinea, Alejandro Andicoechea, Luis O González, Salomé González-Reyes, Antonio M Merino, Luis C Hernández, Alfonso López-Muñiz, Paz García-Pravia, Francisco J Vizoso

Immunohistochemical analysis of oxidative stress and DNA repair proteins in normal mammary and breast cancer tissues

Open Access
Research article

Carol D Curtis, Daniel L Thorngren, Ann M Nardulli

Chemosensitization of cancer cells by siRNA using targeted nanogel delivery

Open Access
Research article

Erin B Dickerson, William H Blackburn, Michael H Smith, Laura B Kapa, L Andrew Lyon, John F McDonald

XIAP is not required for human tumor cell survival in the absence of an exogenous death signal

Open Access
Research article

John Sensintaffar, Fiona L Scott, Robert Peach, Jeffrey H Hager

Bone invading NSCLC cells produce IL-7: mice model and human histologic data

Open Access
Research article

Ilaria Roato, Davide Caldo, Laura Godio, Lucia D'Amico, Paolo Giannoni, Emanuela Morello, Rodolfo Quarto, Luigi Molfetta, Paolo Buracco, Antonio Mussa, Riccardo Ferracini

Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts

Open Access
Research article

Daniel M Appledorn, Kim-Hien T Dao, Sandra O'Reilly, Veronica M Maher, J Justin McCormick

Feasibility of brief psychological distress screening by a community-based telephone helpline for cancer patients and carers

Open Access
Research article

Anna L Hawkes, Karen L Hughes, Sandy D Hutchison, Suzanne K Chambers

Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: Comparison of the CGH profiles between cancer cell lines and primary cancer tissues

Open Access
Research article

Katumi Tsuji, Shigeto Kawauchi, Soichiro Saito, Tomoko Furuya, Kenzo Ikemoto, Motonao Nakao, Shigeru Yamamoto, Masaaki Oka, Takashi Hirano, Kohsuke Sasaki

Stable alterations of CD44 isoform expression in prostate cancer cells decrease invasion and growth and alter ligand binding and chemosensitivity

Open Access
Research article

Kui Yang, Yaqiong Tang, Gabriel K Habermehl, Kenneth A Iczkowski

Cystatin E/M suppresses legumain activity and invasion of human melanoma

Open Access
Research article

Jon J Briggs, Mads H Haugen, Harald T Johansen, Adam I Riker, Magnus Abrahamson, Øystein Fodstad, Gunhild M Mælandsmo, Rigmor Solberg

Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate

Open Access
Research article

Gonzalo Rodríguez-Berriguete, Benito Fraile, Fermín R de Bethencourt, Angela Prieto-Folgado, Nahikari Bartolome, Claudia Nuñez, Bruna Prati, Pilar Martínez-Onsurbe, Gabriel Olmedilla, Ricardo Paniagua, Mar Royuela

Detection of HPV DNA in esophageal cancer specimens from different regions and ethnic groups: a descriptive study

Open Access
Research article

Xueqian Wang, Xiuyun Tian, Fangfang Liu, Yiqiang Zhao, Min Sun, Dafang Chen, Changdong Lu, Zhong Wang, Xiaotian Shi, Qingying Zhang, Donghong Zhang, Zhongying Shen, Feng Li, Curtis C Harris, Hong Cai, Yang Ke

Grp78 promotes the invasion of hepatocellular carcinoma

Open Access
Research article

Rongjian Su, Zhen Li, Hongdan Li, Huijuan Song, Cuifen Bao, Jia Wei, Liufang Cheng

Identification of S100A8-correlated genes for prediction of disease progression in non-muscle invasive bladder cancer

Open Access
Research article

Seon-Kyu Kim, Eun-Jung Kim, Sun-Hee Leem, Yun-Sok Ha, Yong-June Kim, Wun-Jae Kim

Chordoma: clinical characteristics, management and prognosis of a case series of 25 patients

Open Access
Research article

Virginia Ferraresi, Carmen Nuzzo, Carmine Zoccali, Ferdinando Marandino, Antonello Vidiri, Nicola Salducca, Massimo Zeuli, Diana Giannarelli, Francesco Cognetti, Roberto Biagini

Simultaneous CXCL12 and ESR1 CpG island hypermethylation correlates with poor prognosis in sporadic breast cancer

Open Access
Research article

Edneia AS Ramos, Anamaria A Camargo, Karin Braun, Renata Slowik, Iglenir J Cavalli, Enilze MSF Ribeiro, Fábio de O Pedrosa, Emanuel M de Souza, Fabrício F Costa, Giseli Klassen

A multilevel study of the determinants of area-level inequalities in colorectal cancer survival

Open Access
Study protocol

Peter D Baade, Gavin Turrell, Joanne F Aitken

Metastatic lymph node in gastric cancer; Is it a real distant metastasis?

Open Access
Research article

Do Hyoung Lim, Hyeong Su Kim, Young Suk Park, Jeeyun Lee, Se Hoon Park, Ho Yeong Lim, Sang Hoon Ji, Min Jae Park, Seong Yoon Yi, Ji Yeong An, Tae Sung Sohn, Jae Hyoung Noh, Jae Moon Bae, Sung Kim, Cheol Keun Park, Won Ki Kang

Cost-effectiveness analysis of pemetrexed versus docetaxel in the second-line treatment of non-small cell lung cancer in Spain: results for the non-squamous histology population

Open Access
Research article

Yumi Asukai, Amparo Valladares, Carlos Camps, Eifiona Wood, Kaisa Taipale, Jorge Arellano, Alejo Cassinello, José Antonio Sacristán, Tatiana Dilla

MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol

Open Access
Research article

Yu Ren, Xuan Zhou, Mei Mei, Xu-Bo Yuan, Lei Han, Guang-Xiu Wang, Zhi-Fan Jia, Peng Xu, Pei-Yu Pu, Chun-Sheng Kang

Trastuzumab with either docetaxel or vinorelbine as first-line treatment for patients with HER2-positive advanced breast cancer: a retrospective comparison

Open Access
Research article

Stefania Redana, Michela Donadio, Franco Nolè, Maria Elena Jacomuzzi, Alessandra Beano, Rossella Martinello, Anna Sapino, Giuseppe Viale, Massimo Aglietta, Filippo Montemurro

Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model

Open Access
Research article

Jacob E Koskimaki, Emmanouil D Karagiannis, Benjamin C Tang, Hans Hammers, D Neil Watkins, Roberto Pili, Aleksander S Popel

BCNU for recurrent glioblastoma multiforme: efficacy, toxicity and prognostic factors

Open Access
Research article

Thomas Reithmeier, Erika Graf, Tobias Piroth, Michael Trippel, Marcus O Pinsker, Guido Nikkhah

Endometrial cancer in Puerto Rico: incidence, mortality and survival (1992-2003)

Open Access
Research article

Ana Patricia Ortiz, Javier Pérez, Yomayra Otero-Domínguez, Omar García-Rodríguez, Sheyla Garced-Tirado, Frances Escalera-Maldonado, Sadja Gaud-Quintana, Elvis Santiago-Rodríguez, Katherine Svensson, José L Vergara-Arroyo, Karen Ortiz, Mariela Torres, Guillermo Tortolero-Luna, Nayda Figueroa-Vallés

Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation

Open Access
Research article

Yanyuan Wu, Monica Alvarez, Dennis J Slamon, Phillip Koeffler, Jaydutt V Vadgama

Small RNA interference-mediated gene silencing of heparanase abolishes the invasion, metastasis and angiogenesis of gastric cancer cells

Open Access
Research article

Liduan Zheng, Guosong Jiang, Hong Mei, Jiarui Pu, Jihua Dong, Xiaohua Hou, Qiangsong Tong

Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent

Open Access
Research article

Deborah A Altomare, Susanna M Rybak, Jianming Pei, Jacob V Maizel, Mitchell Cheung, Joseph R Testa, Kuslima Shogen

Mammographic density and markers of socioeconomic status: a cross-sectional study

Open Access
Research article

Zoe Aitken, Kate Walker, Bernardine H Stegeman, Petra A Wark, Sue M Moss, Valerie A McCormack, Isabel dos Santos Silva

A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole

Open Access
Research article

Zaida Garcia-Casado, Angel Guerrero-Zotano, Antonio Llombart-Cussac, Ana Calatrava, Antonio Fernandez-Serra, Amparo Ruiz-Simon, Joaquin Gavila, Miguel A Climent, Sergio Almenar, Jose Cervera-Deval, Josefina Campos, Carlos Vazquez Albaladejo, Antonio Llombart-Bosch, Vicente Guillem, Jose A Lopez-Guerrero

Molecular risk assessment of BIG 1-98 participants by expression profiling using RNA from archival tissue

Open Access
Research article

Janine Antonov, Vlad Popovici, Mauro Delorenzi, Pratyaksha Wirapati, Anna Baltzer, Andrea Oberli, Beat Thürlimann, Anita Giobbie-Hurder, Giuseppe Viale, Hans Jörg Altermatt, Stefan Aebi, Rolf Jaggi

Argonaute proteins: potential biomarkers for human colon cancer

Open Access
Research article

Lan Li, Chaohui Yu, Hengjun Gao, Youming Li

Sequential chemotherapy and intensity-modulated radiation therapy in the management of locoregionally advanced nasopharyngeal carcinoma: Experience of 370 consecutive cases

Open Access
Research article

Shaojun Lin, Jiade Jay Lu, Lu Han, Qisong Chen, Jianji Pan

Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer

Open Access
Research article

Amy M Lum, Bruce B Wang, Gabriele B Beck-Engeser, Lauri Li, Namitha Channa, Matthias Wabl

Cellular processes of v-Src transformation revealed by gene profiling of primary cells - Implications for human cancer

Open Access
Research article

Bart M Maślikowski, Benjamin D Néel, Ying Wu, Lizhen Wang, Natalie A Rodrigues, Germain Gillet, Pierre-André Bédard

'Pragmatic randomized controlled trial of individually prescribed exercise versus usual care in a heterogeneous cancer survivor population': A feasibility study PEACH Trial: Prescribed exercise after chemotherapy

Open Access
Study protocol

Julie M Walsh, Juliette Hussey, Emer Guinan, Dearbhaile O' Donnell

TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells

Open Access
Research article

Siyang Zhang, Dawei Guo, Wenting Luo, Qingfu Zhang, Ying Zhang, Chunyan Li, Yao Lu, Zeshi Cui, Xueshan Qiu

Methylation status of individual CpG sites within Alu elements in the human genome and Alu hypomethylation in gastric carcinomas

Open Access
Research article

Shengyan Xiang, Zhaojun Liu, Baozhen Zhang, Jing Zhou, Bu-Dong Zhu, Jiafu Ji, Dajun Deng

Prognostic stratification of patients with advanced renal cell carcinoma treated with sunitinib: comparison with the Memorial Sloan-Kettering prognostic factors model

Open Access
Research article

Aristotelis Bamias, Alexandra Karadimou, Sofia Lampaki, George Lainakis, Lia Malettou, Eleni Timotheadou, Kostas Papazisis, Charalambos Andreadis, Loukas Kontovinis, Ioannis Anastasiou, Kostas Stravodimos, Ioannis Xanthakis, Andreas Skolarikos, Christos Christodoulou, Kostas Syrigos, Christos Papandreou, Evangelia Razi, Urania Dafni, George Fountzilas, Meletios A Dimopoulos

4β-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest

Open Access
Research article

Ching-Yu Yen, Chien-Chih Chiu, Fang-Rong Chang, Jeff Yi-Fu Chen, Chi-Ching Hwang, You-Cheng Hseu, Hsin-Ling Yang, Alan Yueh-Luen Lee, Ming-Tz Tsai, Zong-Lun Guo, Yu-Shan Cheng, Yin-Chang Liu, Yu-Hsuan Lan, Yu-Ching Chang, Ying-Chin Ko, Hsueh-Wei Chang, Yang-Chang Wu

Novel genetic variants in miR-191 gene and familial ovarian cancer

Open Access
Research article

Jie Shen, Richard DiCioccio, Kunle Odunsi, Shashikant B Lele, Hua Zhao

Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference

Open Access
Technical advance

Luca Morandi, Enrico Franceschi, Dario de Biase, Gianluca Marucci, Alicia Tosoni, Mario Ermani, Annalisa Pession, Giovanni Tallini, Alba Brandes

Hemorrhage of brain metastasis from non-small cell lung cancer post gefitinib therapy: two case reports and review of the literature

Open Access
Case report

Dan-Fang Yan, Sen-Xiang Yan, Jing-Song Yang, Yi-Xiang J Wang, Xiao-Li Sun, Xin-Biao Liao, Jun-Qing Liu

Association of nutritional status and serum albumin levels with development of toxicity in patients with advanced non-small cell lung cancer treated with paclitaxel-cisplatin chemotherapy: a prospective study

Open Access
Research article

Oscar Arrieta, Rosa M Michel Ortega, Geraldine Villanueva-Rodríguez, Maria G Serna-Thomé, Diana Flores-Estrada, Consuelo Diaz-Romero, Cindy M Rodríguez, Luis Martínez, Karla Sánchez-Lara

Effect of troglitazone on tumor growth and pulmonary metastasis development of the mouse osteosarcoma cell line LM8

Open Access
Research article

Junichi Aizawa, Kenshi Sakayama, Setsuya Kamei, Teruki Kidani, Haruyasu Yamamoto, Yoshiaki Norimatsu, Hiroshi Masuno

German cancer statistics 2004

Open Access
Research article

Jörg Haberland, Joachim Bertz, Ute Wolf, Thomas Ziese, Bärbel-Maria Kurth

Hybrid capture vs. PCR screening of cervical human papilloma virus infections. Cytological and histological associations in 1270 women

Open Access
Research article

Sotirios Tsiodras, John Georgoulakis, Aikaterini Chranioti, Zanis Voulgaris, Amanda Psyrri, Angeliki Tsivilika, John Panayiotides, Petros Karakitsos

In vitro and in vivo characterization of highly purified Human Mesothelioma derived cells

Open Access
Research article

Alice Melotti, Antonio Daga, Daniela Marubbi, Annalisa Zunino, Luciano Mutti, Giorgio Corte

Identification of hypoxanthine as a urine marker for non-Hodgkin lymphoma by low-mass-ion profiling

Open Access
Research article

Byong Chul Yoo, Sun-Young Kong, Sang-Geun Jang, Kyung-Hee Kim, Sun-A Ahn, Weon-Seo Park, Sohee Park, Tak Yun, Hyeon-Seok Eom

Differential survival following trastuzumab treatment based on quantitative HER2 expression and HER2 homodimers in a clinic-based cohort of patients with metastatic breast cancer

Open Access
Research article

Masakazu Toi, Jeff Sperinde, Weidong Huang, Shigehira Saji, John Winslow, Xueguang Jin, Yuping Tan, Shinji Ohno, Seigo Nakamura, Hiroji Iwata, Norikazu Masuda, Kenjiro Aogi, Satoshi Morita, Christos Petropoulos, Michael Bates

Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment

Open Access
Research article

Sergey V Tokalov, Nasreddin D Abolmaali

Stabilization of mismatch repair gene PMS2 by glycogen synthase kinase 3β is implicated in the treatment of cervical carcinoma

Open Access
Research article

Yuan Zhang, Yi Min Shu, Shu Fang Wang, Bang Hong Da, Ze Hua Wang, Hua Bin Li

Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) overexpression in pancreatic ductal adenocarcinoma correlates with poor survival

Open Access
Research article

David F Schaeffer, Daniel R Owen, Howard J Lim, Andrew K Buczkowski, Stephen W Chung, Charles H Scudamore, David G Huntsman, Sylvia SW Ng, David A Owen

Activated CD4+T cells enhance radiation effect through the cooperation of interferon-γ and TNF-α

Open Access
Research article

Yixiang Wang, Soroosh Radfar, Hung T Khong

Columnar cell lesions of the canine mammary gland: pathological features and immunophenotypic analysis

Open Access
Research article

Enio Ferreira, Helenice Gobbi, Bruna S Saraiva, Geovanni D Cassali

Bladder metastases of appendiceal mucinous adenocarcinoma: a case presentation

Open Access
Case report

Gianluigi Taverna, Matteo Corinti, Piergiuseppe Colombo, Fabio Grizzi, Mauro Severo, Alessando Piccinelli, Guido Giusti, Alessio Benetti, Paolo A Zucali, Pierpaolo Graziotti

Overexpression of Chromatin Assembly Factor-1/p60 helps to predict the prognosis of melanoma patients

Open Access
Research article

Massimo Mascolo, Maria Luisa Vecchione, Gennaro Ilardi, Massimiliano Scalvenzi, Guido Molea, Maria Di Benedetto, Loredana Nugnes, Maria Siano, Gaetano De Rosa, Stefania Staibano

E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer

Open Access
Research article

Narasimhan Kothandaraman, Vladimir B Bajic, Pang NK Brendan, Chan Y Huak, Peh B Keow, Khalil Razvi, Manuel Salto-Tellez, Mahesh Choolani

Expression of survivin detected by immunohistochemistry in the cytoplasm and in the nucleus is associated with prognosis of leiomyosarcoma and synovial sarcoma patients

Open Access
Research article

Helge Taubert, Chris Heidenreich, Hans-Jürgen Holzhausen, Antje Schulz, Matthias Bache, Matthias Kappler, Alexander W Eckert, Peter Würl, Ingo Melcher, Kathrin Hauptmann, Steffen Hauptmann, Klaus-Dieter Schaser

CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors

Open Access
Research article

Cristina Patru, Luciana Romao, Pascale Varlet, Laure Coulombel, Eric Raponi, Josette Cadusseau, François Renault-Mihara, Cécile Thirant, Nadine Leonard, Alain Berhneim, Maria Mihalescu-Maingot, Jacques Haiech, Ivan Bièche, Vivaldo Moura-Neto, Catherine Daumas-Duport, Marie-Pierre Junier, Hervé Chneiweiss

Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice

Open Access
Research article

Chiyo Doi, Noboru Egashira, Atsushi Kawabata, Dharmendra Kumar Maurya, Naomi Ohta, Deepthi Uppalapati, Rie Ayuzawa, Lara Pickel, Yuka Isayama, Deryl Troyer, Susumu Takekoshi, Masaaki Tamura

Pluripotency-associated genes in human nasopharyngeal carcinoma CNE-2 cells are reactivated by a unique epigenetic sub-microenvironment

Open Access
Research article

Jun-Xia Cao, Yu-Xin Cui, Zi-Jie Long, Zhong-Min Dai, Ji-Yan Lin, Yi Liang, Fei-Meng Zheng, Yi-Xin Zeng, Quentin Liu

The 4q27 locus and prostate cancer risk

Open Access
Research article

Elizabeth A Tindall, Hoa N Hoang, Melissa C Southey, Dallas R English, John L Hopper, Graham G Giles, Gianluca Severi, Vanessa M Hayes

Immunoscreening of the extracellular proteome of colorectal cancer cells

Open Access
Research article

Susanne Klein-Scory, Salwa Kübler, Hanna Diehl, Christina Eilert-Micus, Anke Reinacher-Schick, Kai Stühler, Bettina Warscheid, Helmut E Meyer, Wolff Schmiegel, Irmgard Schwarte-Waldhoff

Microarray analysis of DNA damage repair gene expression profiles in cervical cancer cells radioresistant to 252Cf neutron and X-rays

Open Access
Research article

Yi Qing, Xue-Qin Yang, Zhao-Yang Zhong, Xin Lei, Jia-Yin Xie, Meng-Xia Li, De-Bing Xiang, Zeng-Peng Li, Zhen-Zhou Yang, Ge Wang, Dong Wang

Lipophilic aroylhydrazone chelator HNTMB and its multiple effects on ovarian cancer cells

Open Access
Research article

Kyu Kwang Kim, Thilo S Lange, Rakesh K Singh, Laurent Brard

Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines

Open Access
Research article

Siina Junnila, Arto Kokkola, Marja-Liisa Karjalainen-Lindsberg, Pauli Puolakkainen, Outi Monni

Trends in the incidence and survival of multiple myeloma in South East England 1985-2004

Open Access
Research article

Christine Renshaw, Nicolas Ketley, Henrik Møller, Elizabeth A Davies

Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer

Open Access
Research article

Vera N Senchenko, Ekaterina A Anedchenko, Tatiana T Kondratieva, George S Krasnov, Alexei A Dmitriev, Veronika I Zabarovska, Tatiana V Pavlova, Vladimir I Kashuba, Michael I Lerman, Eugene R Zabarovsky

HAX-1 overexpression, splicing and cellular localization in tumors

Open Access
Research article

Alicja Trebinska, Alina Rembiszewska, Karolina Ciosek, Konrad Ptaszynski, Sebastian Rowinski, Jolanta Kupryjanczyk, Janusz A Siedlecki, Ewa A Grzybowska

Gene expression profiles of lung adenocarcinoma linked to histopathological grading and survival but not to EGF-R status: a microarray study

Open Access
Research article

Jens Neumann, Friedrich Feuerhake, Gian Kayser, Thorsten Wiech, Konrad Aumann, Bernward Passlick, Paul Fisch, Martin Werner, Axel zur Hausen

Selective regain of egfr gene copies in CD44+/CD24-/lowbreast cancer cellular model MDA-MB-468

Open Access
Research article

Konstantin Agelopoulos, Burkhard Greve, Hartmut Schmidt, Heike Pospisil, Stefan Kurtz, Kai Bartkowiak, Antje Andreas, Marek Wieczorek, Eberhard Korsching, Horst Buerger, Burkhard Brandt

Expression of ZIC family genes in meningiomas and other brain tumors

Open Access
Research article

Jun Aruga, Yayoi Nozaki, Minoru Hatayama, Yuri S Odaka, Naoki Yokota

Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?

Open Access
Research article

Mark M Aloysius, Abed M Zaitoun, Timothy E Bates, Mohammad Ilyas, Dumitru Constantin-Teodosiu, Brian J Rowlands, Dileep N Lobo

Maternal consumption of canola oil suppressed mammary gland tumorigenesis in C3(1) TAg mice offspring

Open Access
Research article

Gabriela Ion, Juliana A Akinsete, W Elaine Hardman

Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases

Open Access
Research article

Martin Grimm, Martin Gasser, Marco Bueter, Johanna Strehl, Johann Wang, Ekaterina Nichiporuk, Detlef Meyer, Christoph T Germer, Ana M Waaga-Gasser, Andreas Thalheimer

Functional significance of the hepaCAM gene in bladder cancer

Open Access
Research article

Yunfeng He, Xiaohou Wu, Chunli Luo, Lie Wang, Jie Lin

Enhanced antiproliferative and apoptotic response to combined treatment of γ-tocotrienol with erlotinib or gefitinib in mammary tumor cells

Open Access
Research article

Sunitha V Bachawal, Vikram B Wali, Paul W Sylvester

Treatment rationale and study design for a phase III, double-blind, placebo-controlled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small cell lung cancer

Open Access
Study protocol

Luis G Paz-Ares, Sedat Altug, Alexandra Thareau Vaury, Jesús Corral Jaime, Francesca Russo, Carla Visseren-Grul

Parenteral nutrition support for patients with pancreatic cancer. Results of a phase II study

Open Access
Research article

Uwe Pelzer, Dirk Arnold, Mehmet Goevercin, Jens Stieler, Bernd Doerken, Hanno Riess, Helmut Oettle

Pancreatic adenocarcinoma exerts systemic effects on the peripheral blood myeloid and plasmacytoid dendritic cells: an indicator of disease severity?

Open Access
Research article

Vegard Tjomsland, Per Sandström, Anna Spångeus, Davorka Messmer, Johan Emilsson, Ursula Falkmer, Sture Falkmer, Karl-Eric Magnusson, Kurt Borch, Marie Larsson

Effect of MDM2 SNP309 and p53 codon 72 polymorphisms on lung cancer risk and survival among non-smoking Chinese women in Singapore

Open Access
Research article

Hui Wan Chua, Daniel Ng, Serena Choo, San San Lum, Huihua Li, Li Ying Soh, Kanaga Sabapathy, Adeline Seow

Targeting HOX and PBX transcription factors in ovarian cancer

Open Access
Research article

Richard Morgan, Lynn Plowright, Kevin J Harrington, Agnieszka Michael, Hardev S Pandha

Favourable ten-year overall survival in a Caucasian population with high probability of hereditary breast cancer

Open Access
Research article

Laura Cortesi, Cristina Masini, Claudia Cirilli, Veronica Medici, Isabella Marchi, Giovanna Cavazzini, Giuseppe Pasini, Daniela Turchetti, Massimo Federico

Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 expression in glioma cell lines

Open Access
Research article

Marie-Claude Amoureux, Béma Coulibaly, Olivier Chinot, Anderson Loundou, Philippe Metellus, Geneviève Rougon, Dominique Figarella-Branger

Multimodal therapy for synergic inhibition of tumour cell invasion and tumour-induced angiogenesis

Open Access
Research article

Pamela Zengel, Diana Ramp, Brigitte Mack, Stefan Zahler, Alexander Berghaus, Bernd Muehlenweg, Olivier Gires, Suna Schmitz

Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer

Open Access
Research article

Manuela Eppenberger, Inti Zlobec, Daniel Baumhoer, Luigi Terracciano, Alessandro Lugli

Alterations of the extracellular matrix in ovarian cancer studied by Second Harmonic Generation imaging microscopy

Open Access
Research article

Oleg Nadiarnykh, Ronald B LaComb, Molly A Brewer, Paul J Campagnola

The investigation of Mitogen-Activated Protein kinase Phosphatase-1 as a potential pharmacological target in non-small cell lung carcinomas, assisted by non-invasive molecular imaging

Open Access
Research article

Cheng-Jeng Tai, Alexander TH Wu, Jeng-Feng Chiou, Hsun-Jin Jan, Hon-Jian Wei, Chung-Huei Hsu, Che-Tong Lin, Wen-Ta Chiu, Cheng-Wen Wu, Horng-Mo Lee, Win-Ping Deng

Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma

Open Access
Study protocol

Claudia Blattmann, Susanne Oertel, Daniela Schulz-Ertner, Stefan Rieken, Sabine Haufe, Volker Ewerbeck, Andreas Unterberg, Irini Karapanagiotou-Schenkel, Stephanie E Combs, Anna Nikoghosyan, Marc Bischof, Oliver Jäkel, Peter Huber, Andreas E Kulozik, Jürgen Debus

Quantitative methylation profiling in tumor and matched morphologically normal tissues from breast cancer patients

Open Access
Research article

Ilse Van der Auwera, Catherine Bovie, Cecilia Svensson, Xuan B Trinh, Ridha Limame, Peter van Dam, Steven J van Laere, Eric A van Marck, Luc Y Dirix, Peter B Vermeulen

Genetic and epigenetic silencing of the beclin 1gene in sporadic breast tumors

Open Access
Research article

Zidong Li, Bo Chen, Yiqing Wu, Feng Jin, Yongjing Xia, Xiangjun Liu

Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study

Open Access
Research article

Adam Naguib, Panagiota N Mitrou, Laura J Gay, James C Cooke, Robert N Luben, Richard Y Ball, Alison McTaggart, Mark J Arends, Sheila A Rodwell

Inter-country and ethnic variation in colorectal cancer survival: Comparisons between a Philippine population, Filipino-Americans and Caucasians

Open Access
Research article

Maria Theresa Redaniel, Adriano Laudico, Maria Rica Mirasol-Lumague, Adam Gondos, Gemma Uy, Hermann Brenner

A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes

Open Access
Research article

Debora Fumagalli, Patrick G Gavin, Yusuke Taniyama, Seung-Il Kim, Hyun-Joo Choi, Soonmyung Paik, Katherine L Pogue-Geile

Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation

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Wen-Shan Liu, Chung-Han Hsin, Ying-Hsiang Chou, Jung-Tung Liu, Ming-Fang Wu, Szu-Wen Tseng, Jong-Kang Lee, Hsien-Chun Tseng, Tzu-Hwei Wang, Mao-Chang Su, Huei Lee

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

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Anna Martirosyan, James W Clendening, Carolyn A Goard, Linda Z Penn

Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors

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Sally Järvelä, Immo Rantala, Alejandra Rodriguez, Heini Kallio, Seppo Parkkila, Vuokko L Kinnula, Ylermi Soini, Hannu Haapasalo

Long-term survival of cancer patients compared to heart failure and stroke: A systematic review

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Vasileios Askoxylakis, Christian Thieke, Sven T Pleger, Patrick Most, Judith Tanner, Katja Lindel, Hugo A Katus, Jürgen Debus, Marc Bischof

In situ protein expression in tumour spheres: development of an immunostaining protocol for confocal microscopy

Open Access
Technical advance

Louis-Bastien Weiswald, Jean-Marc Guinebretière, Sophie Richon, Dominique Bellet, Bruno Saubaméa, Virginie Dangles-Marie

Effects of clusterin over-expression on metastatic progression and therapy in breast cancer

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Research article

Louise Flanagan, Lorna Whyte, Namita Chatterjee, Martin Tenniswood

The expression of TRMT2A, a novel cell cycle regulated protein, identifies a subset of breast cancer patients with HER2 over-expression that are at an increased risk of recurrence

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David G Hicks, Bagi R Janarthanan, Ramya Vardarajan, Swati A Kulkarni, Thaer Khoury, Daniel Dim, G Thomas Budd, Brian J Yoder, Raymond Tubbs, Marshall T Schreeder, Noel C Estopinal, Rodney A Beck, Yanling Wang, Brian Z Ring, Robert S Seitz, Douglas T Ross

Identification of differentially expressed microRNAs in human male breast cancer

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Ulrich Lehmann, Thomas Streichert, Benjamin Otto, Cord Albat, Britta Hasemeier, Henriette Christgen, Elisa Schipper, Ursula Hille, Hans H Kreipe, Florian Länger

Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways

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Research article

Aaron E Hoffman, Tongzhang Zheng, Yue Ba, Richard G Stevens, Chun-Hui Yi, Derek Leaderer, Yong Zhu

A randomized controlled trial of Human Papillomavirus (HPV) testing for cervicalcancer screening: trial design and preliminary results (HPV FOCAL Trial)

Open Access
Study protocol

Gina S Ogilvie, Dirk J van Niekerk, Mel Krajden, Ruth E Martin, Thomas G Ehlen, Kathy Ceballos, Stuart J Peacock, Laurie W Smith, Lisa Kan, Darrel A Cook, Wendy Mei, Gavin CE Stuart, Eduardo L Franco, Andrew J Coldman

The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time

Open Access
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Junliang Ma, Lunxu Liu, Guowei Che, Nanbin Yu, Fuqiang Dai, Zongbing You

In vitro and in vivo anticancer properties of a Calcarea carbonica derivative complex (M8) treatment in a murine melanoma model

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Fernando SF Guimarães, Lucas F Andrade, Sharon T Martins, Ana PR Abud, Reginaldo V Sene, Carla Wanderer, Inés Tiscornia, Mariela Bollati-Fogolín, Dorly F Buchi, Edvaldo S Trindade

Differential profiling of breast cancer plasma proteome by isotope-coded affinity tagging method reveals biotinidase as a breast cancer biomarker

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Research article

Un-Beom Kang, Younghee Ahn, Jong Won Lee, Yong-Hak Kim, Joon Kim, Myeong-Hee Yu, Dong-Young Noh, Cheolju Lee

Birth length and weight as predictors of breast cancer prognosis

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Research article

Bjørn O Mæhle, Lars J Vatten, Steinar Tretli

CD133 expression in chemo-resistant Ewing sarcoma cells

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Research article

Xiaohua Jiang, Ynnez Gwye, Darren Russell, Christine Cao, Dorothea Douglas, Long Hung, Heinrich Kovar, Timothy J Triche, Elizabeth R Lawlor

Detection of HPV and the role of p16INK4Aoverexpression as a surrogate marker for the presence of functional HPV oncoprotein E7 in colorectal cancer

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Research article

Vanessa Deschoolmeester, Veerle Van Marck, Marc Baay, Christine Weyn, Peter Vermeulen, Eric Van Marck, Filip Lardon, Veronique Fontaine, Jan B Vermorken

Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors

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Research article

Tsuyoshi Mitsuishi, Yukie Iwabu, Kenzo Tokunaga, Tetsutaro Sata, Takehiko Kaneko, Kuniaki Ohara, Ikuroh Ohsawa, Fumino Oda, Yuko Yamada, Seiji Kawana, Kohji Ozaki, Mayuka Nakatake, Osamu Yamada

A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study

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Sivasai Balivada, Raja Shekar Rachakatla, Hongwang Wang, Thilani N Samarakoon, Raj Kumar Dani, Marla Pyle, Franklin O Kroh, Brandon Walker, Xiaoxuan Leaym, Olga B Koper, Masaaki Tamura, Viktor Chikan, Stefan H Bossmann, Deryl L Troyer

The percentage of CD133+ cells in human colorectal cancer cell lines is influenced by Mycoplasma hyorhinis infection

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Elisabetta Mariotti, Marica Gemei, Peppino Mirabelli, Francesca D'Alessio, Rosa Di Noto, Giuliana Fortunato, Luigi Del Vecchio

Cancer resistance of SR/CR mice in the genetic knockout backgrounds of leukocyte effector mechanisms: determinations for functional requirements

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Research article

Anne M Sanders, John R Stehle Jr, Michael J Blanks, Gregory Riedlinger, Jung W Kim-Shapiro, Arta M Monjazeb, Jonathan M Adams, Mark C Willingham, Zheng Cui

Tropomyosin3 overexpression and a potential link to epithelial-mesenchymal transition in human hepatocellular carcinoma

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Research article

Hye-Sun Choi, Seon-Hee Yim, Hai-Dong Xu, Seung-Hyun Jung, Seung-Hun Shin, Hae-Jin Hu, Chan-Kwon Jung, Jong Young Choi, Yeun-Jun Chung

N-Acetylgalactosaminyltransferase-14 as a potential biomarker for breast cancer by immunohistochemistry

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Research article

Chen Wu, Xiaodan Guo, Weina Wang, Yun Wang, Yaojun Shan, Bo Zhang, Wenqian Song, Sisi Ma, Jianfeng Ge, Hao Deng, Mingsheng Zhu

Establishment and identification of a rabbit model of peritoneal carcinomatosis from gastric cancer

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Research article

Lie-Jun Mei, Xiao-Jun Yang, Li Tang, Alaa Hammed al-shammaa Hassan, Yutaka Yonemura, Yan Li

Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer

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Research article

Donal J Brennan, Jenny Brändstedt, Elton Rexhepaj, Michael Foley, Fredrik Pontén, Mathias Uhlén, William M Gallagher, Darran P O'Connor, Colm O'Herlihy, Karin Jirstrom

The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer

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Robert Calaluce, Matthew M Gubin, J Wade Davis, Joseph D Magee, Jing Chen, Yuki Kuwano, Myriam Gorospe, Ulus Atasoy

Focal dose escalation using FDG-PET-guided intensity-modulated radiation therapy boost for postoperative local recurrent rectal cancer: a planning study with comparison of DVH and NTCP

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Research article

Keiichi Jingu, Hisanori Ariga, Tomohiro Kaneta, Yoshihiro Takai, Ken Takeda, Lindel Katja, Kakutaro Narazaki, Takahiro Metoki, Keisuke Fujimoto, Rei Umezawa, Yoshihiro Ogawa, Kenji Nemoto, Masashi Koto, Masatoshi Mitsuya, Naruhiro Matsufuji, Shoki Takahashi, Shogo Yamada

STAMP alters the growth of transformed and ovarian cancer cells

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Research article

Yuanzheng He, John A Blackford Jr, Elise C Kohn, S Stoney Simons Jr

Growth delay of human bladder cancer cells by Prostate Stem Cell Antigen downregulation is associated with activation of immune signaling pathways

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Emanuele Marra, Paolo Uva, Valentina Viti, Valeria Simonelli, Eugenia Dogliotti, Emanuele De Rinaldis, Armin Lahm, Nicola La Monica, Alfredo Nicosia, Gennaro Ciliberto, Fabio Palombo

Moxibustion for cancer care: a systematic review and meta-analysis

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Myeong Soo Lee, Tae-Young Choi, Ji-Eun Park, Song-Shil Lee, Edzard Ernst

High density of peritumoral lymphatic vessels is a potential prognostic marker of endometrial carcinoma: a clinical immunohistochemical method study

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Ying Gao, Zi Liu, Fei Gao, Xiao-yu Meng

Elevated tumor and serum levels of the hypoxia-associated protein osteopontin are associated with prognosis for soft tissue sarcoma patients

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Research article

Matthias Bache, Matthias Kappler, Henri Wichmann, Swetlana Rot, Antje Hahnel, Thomas Greither, Harun M Said, Matthias Kotzsch, Peter Würl, Helge Taubert, Dirk Vordermark

Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma

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Research article

Guo-Fen Yang, Wei-Peng He, Mu-Yan Cai, Li-Ru He, Jun-Hang Luo, Hai-Xia Deng, Xin-Yuan Guan, Mu-Sheng Zeng, Yi-Xin Zeng, Dan Xie

Changes in the renin angiotensin system during the development of colorectal cancer liver metastases

Open Access
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Jaclyn H Neo, Eleanor I Ager, Peter W Angus, Jin Zhu, Chandana B Herath, Christopher Christophi

Tubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells

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Rouba Hage-Sleiman, Stéphanie Herveau, Eva-Laure Matera, Jean-Fabien Laurier, Charles Dumontet

Lack of evidence for KRAS oncogenic mutations in triple-negative breast cancer

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Research article

Alfonso Sánchez-Muñoz, Elena Gallego, Vanessa de Luque, Luís G Pérez-Rivas, Luís Vicioso, Nuria Ribelles, José Lozano, Emilio Alba

In vivo intratumor angiogenic treatment effects during taxane-based neoadjuvant chemotherapy of ovarian cancer

Open Access
Research article

Martin Pölcher, Christian Rudlowski, Nicolaus Friedrichs, Marieke Mielich, Tobias Höller, Mathias Wolfgarten, Kirsten Kübler, Reinhard Büttner, Walther Kuhn, Michael Braun

p16 INK4a hypermethylation and p53, p16 and MDM2 protein expression in Esophageal Squamous Cell Carcinoma

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Noushin Taghavi, Firouzeh Biramijamal, Masoud Sotoudeh, Hooman Khademi, Reza Malekzadeh, Omeed Moaven, Bahram Memar, Azadeh A'rabi, Mohammad Reza Abbaszadegan

TIMP-1 and VEGF-165 serum concentration during first-line therapy of ovarian cancer patients

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Research article

Sven Mahner, Linn Woelber, Christine Eulenburg, Joerg Schwarz, Walter Carney, Fritz Jaenicke, Karin Milde-Langosch, Volkmar Mueller

Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma

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Rita G Ladstein, Ingeborg M Bachmann, Oddbjørn Straume, Lars A Akslen

Protein kinase A regulatory subunit distribution in medulloblastoma

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Research article

Carla Mucignat-Caretta, Luca Denaro, Marco Redaelli, Domenico D'Avella, Antonio Caretta

Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells

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Research article

Gregory B Lesinski, Jason M Zimmerer, Melanie Kreiner, John Trefry, Matthew A Bill, Gregory S Young, Brian Becknell, William E Carson III

Potent inhibition of tumoral hypoxia-inducible factor 1α by albendazole

Open Access
Research article

Mohammad H Pourgholami, Zhao Y Cai, Samina Badar, Kiran Wangoo, Marianne S Poruchynsky, David L Morris

Factors associated with use of breast cancer screening services by women aged ≥ 40 years in Korea: The Third Korea National Health and Nutrition Examination Survey 2005 (KNHANES III)

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Research article

Kiheon Lee, Hyung Taek Lim, Sang Min Park

Lympho-vascular invasion in BRCA related breast cancer compared to sporadic controls

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Research article

Marise R Heerma van Voss, Petra van der Groep, Jos Bart, Elsken van der Wall, Paul J van Diest

Role of nitric oxide in Salmonella typhimurium-mediated cancer cell killing

Open Access
Research article

Yoram Barak, Frank Schreiber, Steve H Thorne, Christopher H Contag, Dirk deBeer, A Matin

Genetic polymorphisms of MDM2 and TP53 genes are associated with risk of nasopharyngeal carcinoma in a Chinese population

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Research article

Mang Xiao, Lei Zhang, Xinhua Zhu, Jun Huang, Huifen Jiang, Sunhong Hu, Yuehui Liu

The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis

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Research article

Kristiina Nordfors, Joonas Haapasalo, Miikka Korja, Anssi Niemelä, Jukka Laine, Anna-Kaisa Parkkila, Silvia Pastorekova, Jaromir Pastorek, Abdul Waheed, William S Sly, Seppo Parkkila, Hannu Haapasalo

Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma

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Research article

Rene' G Feichtinger, Franz Zimmermann, Johannes A Mayr, Daniel Neureiter, Cornelia Hauser-Kronberger, Freimut H Schilling, Neil Jones, Wolfgang Sperl, Barbara Kofler

Epidemiological evaluation of concordance between initial diagnosis and central pathology review in a comprehensive and prospective series of sarcoma patients in the Rhone-Alpes region

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Research article

Antoine Lurkin, Francoise Ducimetière, Dominique Ranchère Vince, Anne-Valérie Decouvelaere, Dominic Cellier, François N Gilly, Dimitri Salameire, Pierre Biron, Guy de Laroche, Jean Yves Blay, Isabelle Ray-Coquard

Increased expression of urokinase plasminogen activator and its cognate receptor in human seminomas

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Research article

Salvatore Ulisse, Enke Baldini, Marcella Mottolese, Steno Sentinelli, Patrizia Gargiulo, Brancato Valentina, Salvatore Sorrenti, Anna Di Benedetto, Enrico De Antoni, Massimino D'Armiento

Factors associated with initial treatment and survival for clinically localized prostate cancer: results from the CDC-NPCR Patterns of Care Study (PoC1)

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Research article

Maria J Schymura, Amy R Kahn, Robert R German, Mei-Chin Hsieh, Rosemary D Cress, Jack L Finch, John P Fulton, Tiefu Shen, Erik Stuckart

Clinical impact of different detection methods for disseminated tumor cells in bone marrow of patients undergoing surgical resection of colorectal liver metastases: a prospective follow-up study

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Research article

F Jeroen Vogelaar, Wilma E Mesker, Arjen M Rijken, Gaby W van Pelt, Antonia M van Leeuwen, Hans J Tanke, Rob A Tollenaar, Gerrit J Liefers

Breast cancer treatment and ethnicity in British Columbia, Canada

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Research article

Parvin Yavari, Maria Cristina Barroetavena, T Greg Hislop, Chris D Bajdik

The lung cancer exercise training study: a randomized trial of aerobic training, resistance training, or both in postsurgical lung cancer patients: rationale and design

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Study protocol

Lee W Jones, Neil D Eves, William E Kraus, Anil Potti, Jeffrey Crawford, James A Blumenthal, Bercedis L Peterson, Pamela S Douglas

Spontaneous feline mammary intraepithelial lesions as a model for human estrogen receptor- and progesterone receptor-negative breast lesions

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Research article

Giovanni P Burrai, Sulma I Mohammed, Margaret A Miller, Vincenzo Marras, Salvatore Pirino, Maria F Addis, Sergio Uzzau, Elisabetta Antuofermo

Hypoxia induces differential translation of enolase/MBP-1

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Research article

Kara C Sedoris, Shelia D Thomas, Donald M Miller

Serum tartrate-resistant acid phosphatase 5b activity as a prognostic marker of survival in breast cancer with bone metastasis

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Research article

Yi-Ying Wu, Anthony J Janckila, Chih-Hung Ku, Cheng-Ping Yu, Jyh-Cherng Yu, Su-Hui Lee, Hsin-Yi Liu, Lung T Yam, Tsu-Yi Chao

Anti-proliferative effect of extremely low frequency electromagnetic field on preneoplastic lesions formation in the rat liver

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Research article

Mónica Noemí Jiménez-García, Jaime Arellanes-Robledo, Diana Ivette Aparicio-Bautista, Miguel Ángel Rodríguez-Segura, Saúl Villa-Treviño, Juan José Godina-Nava

NGX6 gene mediated by promoter methylation as a potential molecular marker in colorectal cancer

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Minji Liu, Ya Peng, Xiaoyan Wang, Qin Guo, Shourong Shen, Guiyuan Li

Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells

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Research article

Zekuan Xu, Yi Zhang, Jiakai Jiang, Yang Yang, Ruihua Shi, Bo Hao, Zhihong Zhang, Zuhu Huang, Jin W Kim, Guoxin Zhang

Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study

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Research article

Li Tang, Gary R Zirpoli, Vijayvel Jayaprakash, Mary E Reid, Susan E McCann, Chukwumere E Nwogu, Yuesheng Zhang, Christine B Ambrosone, Kirsten B Moysich

Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines

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Research article

Shiqian Zhang, Xiaoliang Zhou, Hao Yu, Yunhai Yu

Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer

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Research article

Takao Kamai, Hiromichi Shirataki, Kimihiro Nakanishi, Nobutaka Furuya, Tsunehito Kambara, Hideyuki Abe, Tetsunari Oyama, Ken-Ichiro Yoshida

Analysis of gene expression in prostate cancer epithelial and interstitial stromal cells using laser capture microdissection

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Research article

Jennifer L Gregg, Kathleen E Brown, Eric M Mintz, Helen Piontkivska, Gail C Fraizer

Normal and malignant epithelial cells with stem-like properties have an extended G2 cell cycle phase that is associated with apoptotic resistance

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Research article

Lisa J Harper, Daniela Elena Costea, Luke Gammon, Bilal Fazil, Adrian Biddle, Ian C Mackenzie

Noncutaneous malignant melanoma: a prognostic model from a retrospective multicenter study

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Research article

Hyo Song Kim, Eun Kyoung Kim, Hyun Jung Jun, Sung Yong Oh, Keon Woo Park, Do Hyoung Lim, Soon Il Lee, Jung Han Kim, Kyoung Mee Kim, Dae Ho Lee, Jeeyun Lee

Clinical significance of Phosphatidyl Inositol Synthase overexpression in oral cancer

Open Access
Research article

Jatinder Kaur, Meenakshi Sawhney, Siddartha DattaGupta, Nootan K Shukla, Anurag Srivastava, Ranju Ralhan

Association between TGFBR1*6A and osteosarcoma: A Chinese case-control study

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Research article

Yun-Sheng Hu, Yong Pan, Wen-Hai Li, Yong Zhang, Jun Li, Bao-An Ma

Vascular endothelial growth factor C promotes cervical cancer metastasis via up-regulation and activation of RhoA/ROCK-2/moesin cascade

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Research article

Mian He, Yang Cheng, Wen Li, Qiongshan Liu, Junxiu Liu, Jinghe Huang, Xiaodong Fu

Oncological outcome and patient satisfaction with skin-sparing mastectomy and immediate breast reconstruction: a prospective observational study

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Sara Reefy, Neill Patani, Anne Anderson, Gwyne Burgoyne, Hisham Osman, Kefah Mokbel

Chemokine receptor expression in tumour islets and stroma in non-small cell lung cancer

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Chandra M Ohri, Aarti Shikotra, Ruth H Green, David A Waller, Peter Bradding

MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer

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Kah Hoong Chang, Pieter Mestdagh, Jo Vandesompele, Michael J Kerin, Nicola Miller

Patient satisfaction with nurse-led telephone follow-up after curative treatment for breast cancer

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Research article

Merel L Kimman, Monique MF Bloebaum, Carmen D Dirksen, Ruud MA Houben, Philippe Lambin, Liesbeth J Boersma

Inhibition of metastasis, angiogenesis, and tumor growth by Chinese herbal cocktail Tien-Hsien Liquid

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Research article

Jean-San Chia, Jia-Ling Du, Wei-Bin Hsu, Andy Sun, Chun-Pin Chiang, Won-Bo Wang

Meta-analysis of archived DNA microarrays identifies genes regulated by hypoxia and involved in a metastatic phenotype in cancer cells

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Research article

Michael Pierre, Benoît DeHertogh, Anthoula Gaigneaux, Bertrand DeMeulder, Fabrice Berger, Eric Bareke, Carine Michiels, Eric Depiereux

In vivo tumor cell adhesion in the pulmonary microvasculature is exclusively mediated by tumor cell - endothelial cell interaction

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Research article

Peter Gassmann, Mi-Li Kang, Soeren T Mees, Joerg Haier

Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer

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Research article

Walid Sasi, Wen G Jiang, Anup Sharma, Kefah Mokbel

The spectrum of resistance in SR/CR mice: the critical role of chemoattraction in the cancer/leukocyte interaction

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Research article

Gregory Riedlinger, Jonathan Adams, John R Stehle Jr, Michael J Blanks, Anne M Sanders, Amy M Hicks, Mark C Willingham, Zheng Cui

Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?

Open Access
Research article

Eddy HJ van Roon, Marjo van Puijenbroek, Anneke Middeldorp, Ronald van Eijk, Emile J de Meijer, Dianhdra Erasmus, Kim AD Wouters, Manon van Engeland, Jan Oosting, Frederik J Hes, Carli MJ Tops, Tom van Wezel, Judith M Boer, Hans Morreau

Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication

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Research article

Maija Wolf, Miikka Korja, Ritva Karhu, Henrik Edgren, Sami Kilpinen, Kalle Ojala, Spyro Mousses, Anne Kallioniemi, Hannu Haapasalo

Prognostic utility of chromosomal instability detected by fluorescence in situ hybridization in fine-needle aspirates from oral squamous cell carcinomas

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Research article

Hiroaki Sato, Narikazu Uzawa, Ken-Ichiro Takahashi, Kunihiro Myo, Yoshio Ohyama, Teruo Amagasa

Adhesion of renal carcinoma cells to endothelial cells depends on PKCμ

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Walburgis Brenner, Silke Beitz, Elke Schneider, Frank Benzing, Ronald E Unger, Frederik C Roos, Joachim W Thüroff, Christian Hampel

Elevated IGFIR expression regulating VEGF and VEGF-C predicts lymph node metastasis in human colorectal cancer

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Research article

Chunhui Zhang, Li Hao, Liang Wang, Yichuan Xiao, Hailiang Ge, Zhenya Zhu, Yunbao Luo, Yi Zhang, Yanyun Zhang

Lack of relationship between TIMP-1 tumour cell immunoreactivity, treatment efficacy and prognosis in patients with advanced epithelial ovarian cancer

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Research article

Karina Dahl Steffensen, Marianne Waldstrøm, Rikke Kølby Christensen, Annette Bartels, Nils Brünner, Anders Jakobsen

High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology

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Research article

Valsamo K Anagnostou, Frank J Lowery, Vassiliki Zolota, Vassiliki Tzelepi, Arun Gopinath, Camil Liceaga, Nikolaos Panagopoulos, Konstantina Frangia, Lynn Tanoue, Daniel Boffa, Scott Gettinger, Frank Detterbeck, Robert J Homer, Dimitrios Dougenis, David L Rimm, Konstantinos N Syrigos

Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway

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Research article

Keinosuke Ryu, Michiro Susa, Edwin Choy, Cao Yang, Francis J Hornicek, Henry J Mankin, Zhenfeng Duan

Antitumor and antiangiogenic effect of the dual EGFR and HER-2 tyrosine kinase inhibitor lapatinib in a lung cancer model

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Research article

Roque Diaz, Paul A Nguewa, Ricardo Parrondo, Carlos Perez-Stable, Irene Manrique, Miriam Redrado, Raul Catena, Maria Collantes, Ivan Peñuelas, Juan Antonio Díaz-González, Alfonso Calvo

Epidermal Growth Factor Receptor and K-RAS status in two cohorts of squamous cell carcinomas

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Research article

Nancy Van Damme, Philippe Deron, Nadine Van Roy, Pieter Demetter, Alain Bols, Jo Van Dorpe, Filip Baert, Jean-Luc Van Laethem, Franki Speleman, Patrick Pauwels, Marc Peeters

A prospective randomised, open-labeled, trial comparing sirolimus-containing versus mTOR-inhibitor-free immunosuppression in patients undergoing liver transplantation for hepatocellular carcinoma

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Study protocol

Andreas A Schnitzbauer, Carl Zuelke, Christian Graeb, Justine Rochon, Itxarone Bilbao, Patrizia Burra, Koert P de Jong, Christophe Duvoux, Norman M Kneteman, Rene Adam, Wolf O Bechstein, Thomas Becker, Susanne Beckebaum, Olivier Chazouillères, Umberto Cillo, Michele Colledan, Fred Fändrich, Jean Gugenheim, Johann P Hauss, Michael Heise, Ernest Hidalgo, Neville Jamieson, Alfred Königsrainer, Philipp E Lamby, Jan P Lerut, Heikki Mäkisalo, Raimund Margreiter, Vincenzo Mazzaferro, Ingrid Mutzbauer, Gerd Otto, Georges-Philippe Pageaux, Antonio D Pinna, Jacques Pirenne, Magnus Rizell, Giorgio Rossi, Lionel Rostaing, Andre Roy, Victor Sanchez Turrion, Jan Schmidt, Roberto I Troisi, Bart van Hoek, Umberto Valente, Philippe Wolf, Heiner Wolters, Darius F Mirza, Tim Scholz, Rudolf Steininger, Gunnar Soderdahl, Simone I Strasser, Karl-Walter Jauch, Peter Neuhaus, Hans J Schlitt, Edward K Geissler

Breast cancer histology and receptor status characterization in Asian Indian and Pakistani women in the U.S. - a SEER analysis

Open Access
Research article

Madhuri Kakarala, Laura Rozek, Michele Cote, Samadhi Liyanage, Dean E Brenner

Interference with Activator Protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells

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Research article

Verena Thewes, Francesca Orso, Richard Jäger, Dawid Eckert, Sabine Schäfer, Gregor Kirfel, Stephan Garbe, Daniela Taverna, Hubert Schorle

Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent

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Research article

Adolfo Varona, Lorena Blanco, Itxaro Perez, Javier Gil, Jon Irazusta, José I López, M Luz Candenas, Francisco M Pinto, Gorka Larrinaga

Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats

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Research article

Angelo Pietro Femia, Cristina Luceri, Simona Toti, Augusto Giannini, Piero Dolara, Giovanna Caderni

A new method to detect loss of heterozygosity using cohort heterozygosity comparisons

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Technical advance

Michael R Green, Paul Jardine, Peter Wood, Jeremy Wellwood, Rod A Lea, Paula Marlton, Lyn R Griffiths

Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma

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Research article

Min-Han Tan, Chin Fong Wong, Hwei Ling Tan, Ximing J Yang, Jonathon Ditlev, Daisuke Matsuda, Sok Kean Khoo, Jun Sugimura, Tomoaki Fujioka, Kyle A Furge, Eric Kort, Sophie Giraud, Sophie Ferlicot, Philippe Vielh, Delphine Amsellem-Ouazana, Bernard Debré, Thierry Flam, Nicolas Thiounn, Marc Zerbib, Gérard Benoît, Stéphane Droupy, Vincent Molinié, Annick Vieillefond, Puay Hoon Tan, Stéphane Richard, Bin Tean Teh

Differential CARM1 expression in prostate and colorectal cancers

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Research article

Young-Rang Kim, Byung Kook Lee, Ra-Young Park, Nguyen Thi Xuan Nguyen, Jeong A Bae, Dong Deuk Kwon, Chaeyong Jung

Growth factors in multiple myeloma: a comprehensive analysis of their expression in tumor cells and bone marrow environment using Affymetrix microarrays

Open Access
Research article

Karène Mahtouk, Jérôme Moreaux, Dirk Hose, Thierry Rème, Tobias Meißner, Michel Jourdan, Jean François Rossi, Steven T Pals, Hartmut Goldschmidt, Bernard Klein

A long-term follow-up of the imatinib mesylate treatment for the patients with recurrent gastrointestinal stromal tumor (GIST): the liver metastasis and the outcome

Open Access
Research article

Jiang Zhu, Yu Yang, Lin Zhou, Ming Jiang, Mei Hou

Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy

Open Access
Research article

Soraya I de Oliveira, Luciana NS Andrade, Ana C Onuchic, Sueli Nonogaki, Patrícia D Fernandes, Mônica C Pinheiro, Ciro BS Rohde, Roger Chammas, Sonia Jancar

Seladin-1 expression is regulated by promoter methylation in adrenal cancer

Open Access
Research article

Lisa Simi, Francesca Malentacchi, Paola Luciani, Stefania Gelmini, Cristiana Deledda, Rosaria Arvia, Massimo Mannelli, Alessandro Peri, Claudio Orlando

Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy

Open Access
Research article

Bekim Sadikovic, Paul Thorner, Susan Chilton-MacNeill, Jeff W Martin, Nilva K Cervigne, Jeremy Squire, Maria Zielenska

Clinical significance of preoperative serum vascular endothelial growth factor, interleukin-6, and C-reactive protein level in colorectal cancer

Open Access
Research article

Kyung A Kwon, Sung Hyun Kim, Sung Yong Oh, Suee Lee, Jin-Yeong Han, Kyeong Hee Kim, Ri Young Goh, Hong Jo Choi, Ki Jae Park, Mee Sook Roh, Hyo-Jin Kim, Hyuk-Chan Kwon, Jong Hoon Lee

The siRNA targeted to mdr1b and mdr1a mRNAs in vivosensitizes murine lymphosarcoma to chemotherapy

Open Access
Research article

Olga A Patutina, Nadezda L Mironova, Nelly A Popova, Vasily I Kaledin, Valery P Nikolin, Valentin V Vlassov, Marina A Zenkova

Late tamoxifen in patients previously operated for breast cancer without postoperative tamoxifen: 5-year results of a single institution randomised study

Open Access
Research article

Andrea Veronesi, GianMaria Miolo, Maria D Magri, Diana Crivellari, Simona Scalone, Ettore Bidoli, Davide Lombardi

Comparative proteomic analysis of plasma membrane proteins between human osteosarcoma and normal osteoblastic cell lines

Open Access
Research article

Zhiyu Zhang, Lijun Zhang, Yingqi Hua, Xiaofang Jia, Jian Li, Shuo Hu, Xia Peng, Pengyuan Yang, Mengxiong Sun, Fang Ma, Zhengdong Cai

Decreased transcription-coupled nucleotide excision repair capacity is associated with increased p53- and MLH1-independent apoptosis in response to cisplatin

Open Access
Research article

Lawton J Stubbert, Jennifer M Smith, Bruce C McKay

Prediction of melanoma metastasis by the Shields index based on lymphatic vessel density

Open Access
Research article

Maxine S Emmett, Kirsty E Symonds, Howard Rigby, Martin G Cook, Rebecca Price, Chris Metcalfe, Antonio Orlando, David O Bates

A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma

Open Access
Research article

Tim F Greten, Alejandro Forner, Firouzeh Korangy, Gisele N'Kontchou, Nathalie Barget, Carmen Ayuso, Lars A Ormandy, Michael P Manns, Michel Beaugrand, Jordi Bruix

Aqueous Cinnamon Extract (ACE-c) from the bark of Cinnamomum cassiacauses apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential

Open Access
Research article

Soumya J Koppikar, Amit S Choudhari, Snehal A Suryavanshi, Shweta Kumari, Samit Chattopadhyay, Ruchika Kaul-Ghanekar

Pharmacokinetic properties and antitumor efficacy of the 5-fluorouracil loaded PEG-hydrogel

Open Access
Research article

Hee Yi, Hee-Jung Cho, Soo-Min Cho, Dong-Goo Lee, AM Abd El-Aty, So-Jeong Yoon, Gun-Won Bae, Kwang Nho, Bokyung Kim, Chi-Ho Lee, Jin-Suk Kim, Michael G Bartlett, Ho-Chul Shin

Estrogen regulation of TRPM8 expression in breast cancer cells

Open Access
Research article

Dechen Chodon, Arnaud Guilbert, Isabelle Dhennin-Duthille, Mathieu Gautier, Marie-Sophie Telliez, Henri Sevestre, Halima Ouadid-Ahidouch

Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine

Open Access
Research article

Krishnan Rathinasamy, Bhavya Jindal, Jayant Asthana, Parminder Singh, Petety V Balaji, Dulal Panda

Explaining disparities in colorectal cancer screening among five Asian ethnic groups: A population-based study in California

Open Access
Research article

Annette E Maxwell, Catherine M Crespi, Cynthia M Antonio, Peiyun Lu

Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma

Open Access
Research article

Gerald N DeLorenze, Lucie McCoy, Ai-Lin Tsai, Charles P Quesenberry Jr, Terri Rice, Dora Il'yasova, Margaret Wrensch

Bilateral downregulation of Nav1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with Walker 256 breast tumor cells

Open Access
Research article

Xue-Rong Miao, Xiao-Fei Gao, Jing-Xiang Wu, Zhi-Jie Lu, Zhang-Xiang Huang, Xiao-Qing Li, Cheng He, Wei-Feng Yu

Hypermethylated 14-3-3-σ and ESR1 gene promoters in serum as candidate biomarkers for the diagnosis and treatment efficacy of breast cancer metastasis

Open Access
Research article

Mercedes Zurita, Pedro C Lara, Rosario del Moral, Blanca Torres, José Luis Linares-Fernández, Sandra Ríos Arrabal, Joaquina Martínez-Galán, Francisco Javier Oliver, José Mariano Ruiz de Almodóvar

Aberrant expression of CD133 protein correlates with Ki-67 expression and is a prognostic marker in gastric adenocarcinoma

Open Access
Research article

Po Zhao, Yazhuo Li, Yali Lu

Residual hepatocellular carcinoma after oxaliplatin treatment has increased metastatic potential in a nude mouse model and is attenuated by Songyou Yin

Open Access
Research article

Wei Xiong, Zheng-Gang Ren, Shuang-Jian Qiu, Hui-Chuan Sun, Lu Wang, Bin-Bin Liu, Qi-Song Li, Wei Zhang, Xiao-Dong Zhu, Liang Liu, Wen-Quan Wang, Zhao-You Tang

The number and microlocalization of tumor-associated immune cells are associated with patient's survival time in non-small cell lung cancer

Open Access
Research article

Fuqiang Dai, Lunxu Liu, Guowei Che, Nanbin Yu, Qiang Pu, Shangfu Zhang, Junliang Ma, Lin Ma, Zongbing You

Association between EGF +61 G/A and glioma risk in a Chinese population

Open Access
Research article

Shujie Wang, Yao Zhao, Zhenchao Ruan, Hongyan Chen, Weiwei Fan, Juxiang Chen, Qihan Wu, Ji Qian, Tianbao Zhang, Yan Huang, Daru Lu

A genomic and transcriptomic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer

Open Access
Research article

Jean-Philippe Meyniel, Paul H Cottu, Charles Decraene, Marc-Henri Stern, Jérôme Couturier, Ingrid Lebigot, André Nicolas, Nina Weber, Virginie Fourchotte, Séverine Alran, Audrey Rapinat, David Gentien, Sergio Roman-Roman, Laurent Mignot, Xavier Sastre-Garau

Protein expression profile and prevalence pattern of the molecular classes of breast cancer - a Saudi population based study

Open Access
Research article

Dalal M Al Tamimi, Mohamed A Shawarby, Ayesha Ahmed, Ammar K Hassan, Amal A AlOdaini

Is lymphadenectomy a prognostic marker in endometrioid adenocarcinoma of the human endometrium?

Open Access
Research article

Nina Bassarak, Thomas Blankenstein, Ansgar Brüning, Darius Dian, Florian Bergauer, Klaus Friese, Ioannis Mylonas

Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4

Open Access
Research article

Patricia A Cronin, Jiang H Wang, H Paul Redmond

Histological type and grade of breast cancer tumors by parity, age at birth, and time since birth: a register-based study in Norway

Open Access
Research article

Grethe Albrektsen, Ivar Heuch, Steinar Ø Thoresen

Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features

Open Access
Research article

Pei Woon Ang, Marie Loh, Natalia Liem, Pei Li Lim, Fabienne Grieu, Aparna Vaithilingam, Cameron Platell, Wei Peng Yong, Barry Iacopetta, Richie Soong

Use of ER/PR/HER2 subtypes in conjunction with the 2007 St Gallen Consensus Statement for early breast cancer

Open Access
Research article

Katrina Bauer, Carol Parise, Vincent Caggiano

TTFields alone and in combination with chemotherapeutic agents effectively reduce the viability of MDR cell sub-lines that over-express ABC transporters

Open Access
Research article

Rosa S Schneiderman, Esther Shmueli, Eilon D Kirson, Yoram Palti

The aberrant asynchronous replication — characterizing lymphocytes of cancer patients — is erased following stem cell transplantation

Open Access
Research article

Arnon Nagler, Samuel Cytron, Maya Mashevich, Avital Korenstein-Ilan, Lydia Avivi

Improved survival for non-Hodgkin lymphoma patients in New South Wales, Australia

Open Access
Research article

Xue Q Yu, Wendy H Chen, Dianne L O'Connell

Pretreatment malnutrition and quality of life - association with prolonged length of hospital stay among patients with gynecological cancer: a cohort study

Open Access
Research article

Brenda Laky, Monika Janda, Srinivas Kondalsamy-Chennakesavan, Geoffrey Cleghorn, Andreas Obermair

Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes

Open Access
Research article

Zhihui Wang, Claes G Trope, Vivi Ann Flørenes, Zhenhe Suo, Jahn M Nesland, Ruth Holm

Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokers

Open Access
Research article

William N Rom, Judith D Goldberg, Doreen Addrizzo-Harris, Heather N Watson, Michael Khilkin, Alissa K Greenberg, David P Naidich, Bernard Crawford, Ellen Eylers, Daorong Liu, Eng M Tan

Targeting tissue factor on tumour cells and angiogenic vascular endothelial cells by factor VII-targeted verteporfin photodynamic therapy for breast cancer in vitro and in vivoin mice

Open Access
Research article

Zhiwei Hu, Benqiang Rao, Shimin Chen, Jinzhong Duanmu

Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population

Open Access
Research article

Lian-Hua Cui, Min-Ho Shin, Sun-Seog Kweon, Hee Nam Kim, Hye-Rim Song, Jin-Mei Piao, Jin-Su Choi, Hyun Jeong Shim, Jun Eul Hwang, Hyeong-Rok Kim, Young-Kyu Park, Soo-Hyun Kim

Expression signatures of TP53 mutations in serous ovarian cancers

Open Access
Research article

Marcus Q Bernardini, Tsukasa Baba, Paula S Lee, Jason C Barnett, Gregory P Sfakianos, Angeles Alvarez Secord, Susan K Murphy, Edwin Iversen, Jeffrey R Marks, Andrew Berchuck

Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways

Open Access
Research article

Jairam Vanamala, Lavanya Reddivari, Sridhar Radhakrishnan, Chris Tarver

Primary liposarcoma of the ascending colon: a rare case of mixed type presenting as hemoperitoneum combined with other type of retroperitoneal liposarcoma

Open Access
Case report

Yoon Young Choi, Yong Jin Kim, So Young Jin

Identification of valid reference genes for gene expression studies of human stomach cancer by reverse transcription-qPCR

Open Access
Research article

Hyun-Wook Rho, Byoung-Chan Lee, Eun-Seok Choi, Il-Ju Choi, Yeon-Su Lee, Sung-Ho Goh

Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-κB

Open Access
Research article

Ida Grotterød, Gunhild M Mælandsmo, Kjetil Boye

Development of an enzyme-linked immunosorbent assay for the detection of human calretinin in plasma and serum of mesothelioma patients

Open Access
Technical advance

Irina Raiko, Ingrid Sander, Daniel G Weber, Monika Raulf-Heimsoth, Adrian Gillissen, Jens Kollmeier, Arnaud Scherpereel, Thomas Brüning, Georg Johnen

Canine classical seminoma: a specific malignant type with human classifications is highly correlated with tumor angiogenesis

Open Access
Research article

Jong-Hyuk Kim, Chi-Ho Yu, Ji-Young Yhee, Keum-Soon Im, Na-Hyun Kim, Jung-Hyang Sur

Estradiol suppresses tissue androgens and prostate cancer growth in castration resistant prostate cancer

Open Access
Research article

Bruce Montgomery, Peter S Nelson, Robert Vessella, Tom Kalhorn, David Hess, Eva Corey

Inhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin

Open Access
Research article

Ai-Li Shiau, Min-Li Teo, Shin-Yao Chen, Chrong-Reen Wang, Jeng-Long Hsieh, Meng-Ya Chang, Chih-Jui Chang, Julie Chao, Lee Chao, Chao-Liang Wu, Che-Hsin Lee

Primary myxofibrosarcoma of the parotid: case report

Open Access
Case report

Xu Li, Xin Chen, Zhao-Hui Shi, Yang Chen, Jing Ye, Li Qiao, Jian-Hua Qiu

CDO1 Promoter Methylation is a Biomarker for Outcome Prediction of Anthracycline Treated, Estrogen Receptor-Positive, Lymph Node-Positive Breast Cancer Patients

Open Access
Research article

Dimo Dietrich, Manuel Krispin, Jörn Dietrich, Anne Fassbender, Jörn Lewin, Nadia Harbeck, Manfred Schmitt, Serenella Eppenberger-Castori, Vincent Vuaroqueaux, Frédérique Spyratos, John A Foekens, Ralf Lesche, John WM Martens

Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity

Open Access
Research article

Jongchan Kim, Meejeon Roh, Sarki A Abdulkadir

Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop

Open Access
Research article

Mattias K Andersson, Melker Göransson, Anita Olofsson, Carola Andersson, Pierre Åman

Overexpression of S100A4 in human cancer cell lines resistant to methotrexate

Open Access
Research article

Nuria Mencía, Elisabet Selga, Isabel Rico, M Cristina de Almagro, Xenia Villalobos, Sara Ramirez, Jaume Adan, Jose L Hernández, Véronique Noé, Carlos J Ciudad

Breast and other cancer dormancy as a therapeutic endpoint: speculative recombinant T cell receptor ligand (RTL) adjuvant therapy worth considering?

Open Access
Hypothesis

Tibor Bakács, Jitendra N Mehrishi

Effects of bevacizumab plus irinotecan on response and survival in patients with recurrent malignant glioma: a systematic review and survival-gain analysis

Open Access
Research article

Tao Xu, Juxiang Chen, Yicheng Lu, Johannes EA Wolff

Putative tumour-suppressor gene DAB2is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma

Open Access
Research article

Joanna H Tong, David C Ng, Shuk L Chau, Ken K So, Patrick P Leung, Tin L Lee, Raymond W Lung, Michael W Chan, Anthony W Chan, Kwok W Lo, Ka F To

Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis

Open Access
Research article

Lorenza Venturini, Rosita Motta, Alessandro Gronchi, MariaGrazia Daidone, Nadia Zaffaroni

The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors

Open Access
Research article

Carol M Lee, Ian F Tannock

Immunophenotypic features of tumor infiltrating lymphocytes from mammary carcinomas in female dogs associated with prognostic factors and survival rates

Open Access
Research article

Alessandra Estrela-Lima, Márcio SS Araújo, João M Costa-Neto, Andréa Teixeira-Carvalho, Stella M Barrouin-Melo, Sergio V Cardoso, Olindo A Martins-Filho, Rogéria Serakides, Geovanni D Cassali

Carmustine and methotrexate in combination after whole brain radiation therapy in breast cancer patients presenting with brain metastases: a retrospective study

Open Access
Research article

William Jacot, Marie-Cécile Gerlotto-Borne, Simon Thezenas, Stéphane Pouderoux, Sylvain Poujol, Mahdi About, Gilles Romieu

Micronutrients attenuate progression of prostate cancer by elevating the endogenous inhibitor of angiogenesis, Platelet Factor-4

Open Access
Research article

David Cervi, Brian Pak, Natalie A Venier, Linda M Sugar, Robert K Nam, Neil E Fleshner, Laurence H Klotz, Vasundara Venkateswaran

Human Papilloma Virus prevalence and type-specific relative contribution in invasive cervical cancer specimens from Italy

Open Access
Research article

Luciano Mariani, Núria Monfulleda, Laia Alemany, Enrico Vizza, Ferdinando Marandino, Amina Vocaturo, Maria Benevolo, Beatriz Quirós, Belén Lloveras, Jo Ellen Klaustermeier, Wim Quint, Silvia de Sanjosé, Fs Xavier Bosch

Fractal dimension of chromatin is an independent prognostic factor for survival in melanoma

Open Access
Research article

Valcinir Bedin, Randall L Adam, Bianca CS de Sá, Gilles Landman, Konradin Metze

Induction of cytotoxic T lymphocytes primed with Tumor RNA-loaded Dendritic Cells in esophageal squamous cell carcinoma: preliminary step for DC vaccine design

Open Access
Research article

Mehran Gholamin, Omeed Moaven, Moein Farshchian, Mahmoud Mahmoudi, Mojtaba Sankian, Bahram Memar, Mohammad Naser Forghani, Reza Malekzadeh, Mohammad Taghi Rajabi-Mashhadi, Mohammad Reza Abbaszadegan

High-throughput miRNA profiling of human melanoma blood samples

Open Access
Research article

Petra Leidinger, Andreas Keller, Anne Borries, Jörg Reichrath, Knuth Rass, Sven U Jager, Hans-Peter Lenhof, Eckart Meese

The microenvironment determines the breast cancer cells' phenotype: organization of MCF7 cells in 3D cultures

Open Access
Research article

Silva Krause, Maricel V Maffini, Ana M Soto, Carlos Sonnenschein

Malignant fibrous histiocytoma of the distal femur after an arthroscopic anterior cruciate ligament reconstruction: A case report and a review of the literature

Open Access
Case report

Turgay Efe, Thomas J Heyse, Markus D Schofer, Susanne Fuchs-Winkelmann, Peter Rexin, Jan Schmitt

Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivotumor growth

Open Access
Research article

Pedro Andreu-Pérez, Javier Hernandez-Losa, Teresa Moliné, Rosa Gil, Judit Grueso, Anna Pujol, Javier Cortés, Matias A Avila, Juan A Recio

Cancer risk assessment of ethyl carbamate in alcoholic beverages from Brazil with special consideration to the spirits cachaça and tiquira

Open Access
Research article

Dirk W Lachenmeier, Maria CP Lima, Ian CC Nóbrega, José AP Pereira, Florence Kerr-Corrêa, Fotis Kanteres, Jürgen Rehm

The optimal number of lymph nodes examined in stage II colorectal cancer and its impact of on outcomes

Open Access
Research article

Hok Kwok Choi, Wai Lun Law, Jensen TC Poon

Differential expression of centrosomal proteins at different stages of human glioma

Open Access
Research article

Joon-Khim Loh, Ann-Shung Lieu, Chia-Hua Chou, Fang-Yi Lin, Chia-Hung Wu, Sheng-Long Howng, Chung-Ching Chio, Yi-Ren Hong

Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells

Open Access
Research article

Xiang Wu, Yu Zhu, Huiqin Yan, Boning Liu, Ying Li, Qinghua Zhou, Ke Xu

Increased expression of MMP9 is correlated with poor prognosis of nasopharyngeal carcinoma

Open Access
Research article

Zhen Liu, Lixia Li, Zhixiong Yang, Weiren Luo, Xin Li, Huiling Yang, Kaitai Yao, Bin Wu, Weiyi Fang

hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis

Open Access
Research article

Jillian de Wilde, Jan M Kooter, Renée M Overmeer, Debbie Claassen-Kramer, Chris JLM Meijer, Peter JF Snijders, Renske DM Steenbergen

Physical Activity during Cancer Treatment (PACT) Study: design of a randomised clinical trial

Open Access
Study protocol

Miranda J Velthuis, Anne M May, Ria AG Koppejan-Rensenbrink, Brigitte CM Gijsen, Eric van Breda, G Ardine de Wit, Carin D Schröder, Evelyn M Monninkhof, Eline Lindeman, Elsken van der Wall, Petra HM Peeters

Periostin is up-regulated in high grade and high stage prostate cancer

Open Access
Research article

Verena Tischler, Florian R Fritzsche, Peter J Wild, Carsten Stephan, Hans-Helge Seifert, Marc-Oliver Riener, Thomas Hermanns, Ashkan Mortezavi, Josefine Gerhardt, Peter Schraml, Klaus Jung, Holger Moch, Alex Soltermann, Glen Kristiansen

Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study

Open Access
Research article

Hoirun Nisa, Suminori Kono, Guang Yin, Kengo Toyomura, Jun Nagano, Ryuichi Mibu, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Takafumi Maekawa, Yohichi Yasunami, Kenji Takenaka, Hitoshi Ichimiya, Reiji Terasaka

Soluble Fas might serve as a diagnostic tool for gastric adenocarcinoma

Open Access
Technical advance

Samaneh Boroumand-Noughabi, Hamid Reza Sima, Kamran Ghaffarzadehgan, Mostafa Jafarzadeh, Hamid Reza Raziee, Hanieh Hosseinnezhad, Omeed Moaven, Mohammad Taghi Rajabi-Mashhadi, Amir Abbas Azarian, Mojtaba Mashhadinejad, Jalil Tavakkol-Afshari

Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo

Open Access
Research article

Phan LCHB Tran, Soo-A Kim, Hong Seok Choi, Jung-Hoon Yoon, Sang-Gun Ahn

Surrogate endpoints for overall survival in digestive oncology trials: which candidates? A questionnaires survey among clinicians and methodologists

Open Access
Research article

Nicolas Methy, Laurent Bedenne, Franck Bonnetain

CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women

Open Access
Research article

Koushik Chatterjee, Collet Dandara, Margaret Hoffman, Anna-Lise Williamson

Hopefulness predicts resilience after hereditary colorectal cancer genetic testing: a prospective outcome trajectories study

Open Access
Research article

Samuel MY Ho, Judy WC Ho, George A Bonanno, Annie TW Chu, Emily MS Chan

Centrosome clustering and cyclin D1 gene amplification in double minutes are common events in chromosomal unstable bladder tumors

Open Access
Research article

Javier del Rey, Esther Prat, Immaculada Ponsa, Josep Lloreta, Antoni Gelabert, Ferran Algaba, Jordi Camps, Rosa Miró

Incidence of chemotherapy-induced amenorrhea associated with epirubicin, docetaxel and navelbine in younger breast cancer patients

Open Access
Research article

Wen-Bin Zhou, Hong Yin, Xiao-An Liu, Xiao-Ming Zha, Lin Chen, Jun-Cheng Dai, Ai-di Tao, Ling Chen, Jing-Jing Ma, Li-Jun Ling, Shui Wang

Quercetin abrogates chemoresistance in melanoma cells by modulating ΔNp73

Open Access
Research article

Thilakavathy Thangasamy, Sivanandane Sittadjody, Geoffrey C Mitchell, Erin E Mendoza, Vijayababu M Radhakrishnan, Kirsten H Limesand, Randy Burd

Combined effects of IL-8 and CXCR2gene polymorphisms on breast cancer susceptibility and aggressiveness

Open Access
Research article

Kaouther Snoussi, Wijden Mahfoudh, Noureddine Bouaouina, Meriem Fekih, Hedi Khairi, Ahmed N Helal, Lotfi Chouchane

Anaemia and thrombocytopenia in patients with prostate cancer and bone metastases

Open Access
Research article

Carsten Nieder, Ellinor Haukland, Adam Pawinski, Astrid Dalhaug

Lung cancer risk in never-smokers: a population-based case-control study of epidemiologic risk factors

Open Access
Research article

Darren R Brenner, Rayjean J Hung, Ming-Sound Tsao, Frances A Shepherd, Michael R Johnston, Steven Narod, Warren Rubenstein, John R McLaughlin

Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines

Open Access
Research article

Qiwei Yang, Yufeng Tian, Kelly R Ostler, Alexandre Chlenski, Lisa J Guerrero, Helen R Salwen, Lucy A Godley, Susan L Cohn

Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations

Open Access
Research article

Till Krech, Margarethe Thiede, Ellen Hilgenberg, Reinhold Schäfer, Karsten Jürchott

ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors

Open Access
Research article

Heléne Gustavsson, Tajana Tešan, Karin Jennbacken, Kouji Kuno, Jan-Erik Damber, Karin Welén

An association between anti-platelet drug use and reduced cancer prevalence in diabetic patients: results from the Vermont Diabetes Information System Study

Open Access
Research article

Chris E Holmes, Maria E Ramos-Nino, Benjamin Littenberg

Identification of galectin-7 as a potential biomarker for esophageal squamous cell carcinoma by proteomic analysis

Open Access
Research article

Xi Zhu, Ming Ding, Mei-Lan Yu, Ming-Xiang Feng, Li-Jie Tan, Fu-Kun Zhao

Inferring predominant pathways in cellular models of breast cancer using limited sample proteomic profiling

Open Access
Research article

Yogesh M Kulkarni, Vivian Suarez, David J Klinke II

Exercise and the Prevention of Oesophageal Cancer (EPOC) study protocol: a randomized controlled trial of exercise versus stretching in males with Barrett's oesophagus

Open Access
Study protocol

Brooke M Winzer, Jennifer D Paratz, Marina M Reeves, David C Whiteman

Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth

Open Access
Research article

Victoria T Fabris, Ana Sahores, Silvia I Vanzulli, Lucas Colombo, Alfredo A Molinolo, Claudia Lanari, Caroline A Lamb

Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation

Open Access
Research article

Jessica McCready, Jessica D Sims, Doug Chan, Daniel G Jay

Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung

Open Access
Research article

Tatyana Kalinina, Cenap Güngör, Sabrina Thieltges, Maren Möller-Krull, Eva Maria Murga Penas, Daniel Wicklein, Thomas Streichert, Udo Schumacher, Viacheslav Kalinin, Ronald Simon, Benjamin Otto, Judith Dierlamm, Heidi Schwarzenbach, Katharina E Effenberger, Maximilian Bockhorn, Jakob R Izbicki, Emre F Yekebas

Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarray

Open Access
Research article

Elin Möllerström, Anikó Kovács, Kristina Lövgren, Szilard Nemes, Ulla Delle, Anna Danielsson, Toshima Parris, Donal J Brennan, Karin Jirström, Per Karlsson, Khalil Helou

Promoter- and cell-specific epigenetic regulation of CD44, Cyclin D2, GLIPR1 and PTEN by Methyl-CpG binding proteins and histone modifications

Open Access
Research article

Imke Müller, Frank Wischnewski, Klaus Pantel, Heidi Schwarzenbach

The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts

Open Access
Research article

Hichame Id Boufker, Laurence Lagneaux, Mehdi Najar, Martine Piccart, Ghanem Ghanem, Jean-Jacques Body, Fabrice Journé

Different significance between intratumoral and peritumoral lymphatic vessel density in gastric cancer: a retrospective study of 123 cases

Open Access
Research article

Xiao-Lei Wang, Jian-Ping Fang, Ru-Yong Tang, Xi-Mei Chen

SMAD4 - Molecular gladiator of the TGF-β signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRASproto-oncogene

Open Access
Research article

A Syed Sameer, Nissar A Chowdri, Nidda Syeed, Mujeeb Z Banday, Zaffar A Shah, Mushtaq A Siddiqi

SNAI2/Slug promotes growth and invasion in human gliomas

Open Access
Research article

Hong Wei Yang, Lata G Menon, Peter M Black, Rona S Carroll, Mark D Johnson

Expression of growth factor receptors and targeting of EGFR in cholangiocarcinoma cell lines

Open Access
Research article

Ling Xu, Martin Hausmann, Wolfgang Dietmaier, Silvia Kellermeier, Theresa Pesch, Manuela Stieber-Gunckel, Elisabeth Lippert, Frank Klebl, Gerhard Rogler

Mutations in TGFbeta-RII and BAXmediate tumor progression in the later stages of colorectal cancer with microsatellite instability

Open Access
Research article

Masakazu Yashiro, Kosei Hirakawa, C Richard Boland

Adherence to cancer screening guidelines across Canadian provinces: an observational study

Open Access
Research article

Erin C Strumpf, Zhijin Chai, Srikanth Kadiyala

Health-related quality of life in glioma patients in China

Open Access
Research article

Jin-xiang Cheng, Bo-lin Liu, Xiang Zhang, Wei Lin, Yong-qiang Zhang, Wei-ping Liu, Jian-ning Zhang, Hong Lin, Rui Wang, Hong Yin

14-3-3epsiloncontributes to tumour suppression in laryngeal carcinoma by affecting apoptosis and invasion

Open Access
Research article

Xing-Hua Che, Hong Chen, Zhen-Ming Xu, Chao Shang, Kai-Lai Sun, Wei-Neng Fu

Necrosis related HIF-1α expression predicts prognosis in patients with endometrioid endometrial carcinoma

Open Access
Research article

Laura MS Seeber, Nicole Horrée, Petra van der Groep, Elsken van der Wall, René HM Verheijen, Paul J van Diest

Does D3 surgery offer a better survival outcome compared to D1 surgery for gastric cancer? A result based on a hospital population of two decades as taking D2 surgery for reference

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Research article

Hao Zhang, Caigang Liu, Di Wu, Yi Meng, Ruonan Song, Ping Lu, Shubao Wang

Peri-operative chemotherapy for the treatment of resectable liver metastases from colorectal cancer: A systematic review and meta-analysis of randomized trials

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Research article

Martina Wieser, Stefan Sauerland, Dirk Arnold, Wolff Schmiegel, Anke Reinacher-Schick

Self-reported history of Pap-smear in HIV-positive women in Northern Italy: a cross-sectional study

Open Access
Research article

Luigino Dal Maso, Silvia Franceschi, Mauro Lise, Priscilla Sassoli de' Bianchi, Jerry Polesel, Florio Ghinelli, Fabio Falcini, Alba C Finarelli

Lineage analysis of early and advanced tubular adenocarcinomas of the stomach: continuous or discontinuous?

Open Access
Research article

Takahisa Nakayama, Zhi-Qiang Ling, Ken-ichi Mukaisho, Takanori Hattori, Hiroyuki Sugihara

Irradiation-induced telomerase activity and gastric cancer risk: a case-control analysis in a Chinese Han population

Open Access
Research article

Xianli He, Qing Qiao, Naijian Ge, Jing Nan, Shuqun Shen, Zizhong Wang, Yefa Yang, Guoqiang Bao

Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer

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Research article

Jennifer Gjerde, Jürgen Geisler, Steinar Lundgren, Dagfinn Ekse, Jan Erik Varhaug, Gunnar Mellgren, Vidar M Steen, Ernst A Lien

Altered time structure of neuro-endocrine-immune system function in lung cancer patients

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Research article

Gianluigi Mazzoccoli, Gianluigi Vendemiale, Angelo De Cata, Stefano Carughi, Roberto Tarquini

Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer

Open Access
Research article

Lorna W Harries, John RB Perry, Paul McCullagh, Malcolm Crundwell

Activation of endogenous p53 by combined p19Arf gene transfer and nutlin-3 drug treatment modalities in the murine cell lines B16 and C6

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Research article

Christian A Merkel, Rafael B da Silva Soares, Anna Carolina V de Carvalho, Daniela B Zanatta, Marcio C Bajgelman, Paula Fratini, Eugenia Costanzi-Strauss, Bryan E Strauss

Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma

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Research article

Antal Csepregi, Matthias PA Ebert, Christoph Röcken, Regine Schneider-Stock, Juliane Hoffmann, Hans-Ulrich Schulz, Albert Roessner, Peter Malfertheiner

Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer and have inverse effects on invasion and migration of lung cancer cells

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Research article

Lili Jiang, Qin Huang, Siyang Zhang, Qingfu Zhang, Jihong Chang, Xueshan Qiu, Enhua Wang

Robust multi-tissue gene panel for cancer detection

Open Access
Research article

Joseph Irgon, C Chris Huang, Yi Zhang, Dmitri Talantov, Gyan Bhanot, Sándor Szalma

Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: effects of preoperative chemotherapy

Open Access
Research article

Mariusz Koda, Luiza Kanczuga-Koda, Mariola Sulkowska, Eva Surmacz, Stanislaw Sulkowski

Clinical outcomes and prognostic factors in patients with breast diffuse large B cell lymphoma; Consortium for Improving Survival of Lymphoma (CISL) study

Open Access
Research article

Ho-Young Yhim, Hye Jin Kang, Yoon Hee Choi, Seok Jin Kim, Won Seog Kim, Yee Soo Chae, Jin Seok Kim, Chul Won Choi, Sung Yong Oh, Hyeon Seok Eom, Jeong-A Kim, Jae Hoon Lee, Jong-Ho Won, Hyeok Shim, Je-Jung Lee, Hwa Jung Sung, Hyo Jung Kim, Dae Ho Lee, Cheolwon Suh, Jae-Yong Kwak

Ectopic primary type A thymoma located in two thoracic vertebras: a case report

Open Access
Case report

Ferdinando Marandino, Carmine Zoccali, Nicola Salducca, Mirella Marino, Paolo Visca

Tumour necrosis factor-alpha expression in tumour islets confers a survival advantage in non-small cell lung cancer

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Research article

Chandra M Ohri, Aarti Shikotra, Ruth H Green, David A Waller, Peter Bradding

Early invasive vulvar squamous cell carcinoma arising in a woman with vulvar pemphigus vulgaris and systemic lupus erythematosus

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Case report

Giuseppe Bifulco, Vincenzo D Mandato, Roberto Piccoli, Pierluigi Giampaolino, Chiara Mignogna, Michele D Mignogna, Luigi Costagliola, Carmine Nappi

Targeting surface nucleolin with a multivalent pseudopeptide delays development of spontaneous melanoma in RET transgenic mice

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Research article

Diala El Khoury, Damien Destouches, Renée Lengagne, Bernard Krust, Yamina Hamma-Kourbali, Marylène Garcette, Sandra Niro, Masashi Kato, Jean-Paul Briand, José Courty, Ara G Hovanessian, Armelle Prévost-Blondel

Identification of viral infections in the prostate and evaluation of their association with cancer

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Research article

Margarita L Martinez-Fierro, Robin J Leach, Lauro S Gomez-Guerra, Raquel Garza-Guajardo, Teresa Johnson-Pais, Joke Beuten, Idelma B Morales-Rodriguez, Mario A Hernandez-Ordoñez, German Calderon-Cardenas, Rocio Ortiz-Lopez, Ana M Rivas-Estilla, Jesus Ancer-Rodriguez, Augusto Rojas-Martinez

Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells

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Research article

Luc Friboulet, Claire Gourzones, Sai Wah Tsao, Yannis Morel, Carine Paturel, Stéphane Témam, Catherine Uzan, Pierre Busson

Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cells

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Research article

Nitin Koul, Vivek Sharma, Deobrat Dixit, Sadashib Ghosh, Ellora Sen

Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells

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Research article

Jørn Henriksen, Marianne Stabell, Leonardo A Meza-Zepeda, Silje AU Lauvrak, Moustapha Kassem, Ola Myklebost

The CS1 segment of fibronectin is involved in human OSCC pathogenesis by mediating OSCC cell spreading, migration, and invasion

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Research article

Pachiyappan Kamarajan, Angeles Garcia-Pardo, Nisha J D'Silva, Yvonne L Kapila

EpCAM nuclear localization identifies aggressive Thyroid Cancer and is a marker for poor prognosis

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Research article

Ranju Ralhan, Jun Cao, Terence Lim, Christina MacMillan, Jeremy L Freeman, Paul G Walfish

Does delay in diagnosing colorectal cancer in symptomatic patients affect tumor stage and survival? A population-based observational study

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Research article

Jochim S Terhaar sive Droste, Frank A Oort, René WM van der Hulst, Veerle MH Coupé, Mike E Craanen, Gerrit A Meijer, Linde M Morsink, Otto Visser, Roy LJ van Wanrooij, Chris JJ Mulder

Serum CD26 is related to histopathological polyp traits and behaves as a marker for colorectal cancer and advanced adenomas

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Research article

Loretta De Chiara, Ana M Rodríguez-Piñeiro, Francisco J Rodríguez-Berrocal, Oscar J Cordero, David Martínez-Ares, María Páez de la Cadena

8q24 sequence variants in relation to prostate cancer risk among men of African descent: A case-control study

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Research article

Marnita L Benford, Tiva T VanCleave, Nicole A Lavender, Rick A Kittles, LaCreis R Kidd

Elevated MED28 expression predicts poor outcome in women with breast cancer

Open Access
Research article

Nam K Yoon, Erin L Maresh, Yahya Elshimali, Ai Li, Steve Horvath, David B Seligson, David Chia, Lee Goodglick

An 8-gene qRT-PCR-based gene expression score that has prognostic value in early breast cancer

Open Access
Research article

Iker Sánchez-Navarro, Angelo Gámez-Pozo, Álvaro Pinto, David Hardisson, Rosario Madero, Rocío López, Belén San José, Pilar Zamora, Andrés Redondo, Jaime Feliu, Paloma Cejas, Manuel González Barón, Juan Ángel Fresno Vara, Enrique Espinosa

Cardiotoxicity of anthracycline agents for the treatment of cancer: Systematic review and meta-analysis of randomised controlled trials

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Research article

Lesley A Smith, Victoria R Cornelius, Christopher J Plummer, Gill Levitt, Mark Verrill, Peter Canney, Alison Jones

Pituitary hCG production and cerebral tuberculosis mimicking disease progression during chemotherapy for an advanced ovarian germ cell tumour

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Case report

Serena Rakha, Clare Bayliss, Frances Sanderson, Richard Smith, Michael Seckl, Philip Savage

Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells

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Research article

Hiromichi Nakabayashi, Toshio Yawata, Keiji Shimizu

Putative contribution of CD56 positive cells in cetuximab treatment efficacy in first-line metastatic colorectal cancer patients

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Research article

Raphaël Maréchal, Jef De Schutter, Nathalie Nagy, Pieter Demetter, Arnaud Lemmers, Jacques Devière, Isabelle Salmon, Sabine Tejpar, Jean-Luc Van Laethem

Insulin-like growth factor II mRNA binding protein 3 (IMP3) is overexpressed in prostate cancer and correlates with higher Gleason scores

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Research article

Kristian Ikenberg, Florian R Fritzsche, Ursina Zuerrer-Haerdi, Irina Hofmann, Thomas Hermanns, Helge Seifert, Michael Müntener, Maurizio Provenzano, Tullio Sulser, Silvia Behnke, Josefine Gerhardt, Ashkan Mortezavi, Peter Wild, Ferdinand Hofstädter, Maximilian Burger, Holger Moch, Glen Kristiansen

Modulation of mdm2 pre-mRNA splicing by 9-aminoacridine-PNA (peptide nucleic acid) conjugates targeting intron-exon junctions

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Research article

Takehiko Shiraishi, Jonhard Eysturskarð, Peter E Nielsen

Neoplastic transformation of breast epithelial cells by genotoxic stress

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Research article

Mahendran Botlagunta, Paul T Winnard Jr, Venu Raman

Tanzanian malignant lymphomas: WHO classification, presentation, ploidy, proliferation and HIV/EBV association

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Research article

Amos R Mwakigonja, Ephata E Kaaya, Thomas Heiden, German Wannhoff, Juan Castro, Fatemeh Pak, Anna Porwit, Peter Biberfeld

Enhancing return-to-work in cancer patients, development of an intervention and design of a randomised controlled trial

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Study protocol

Sietske J Tamminga, Angela GEM de Boer, Jos HAM Verbeek, Taina Taskila, Monique HW Frings-Dresen

Modeling the Aneuploidy Control of Cancer

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Research article

Yao Li, Arthur Berg, Louie R Wu, Zhong Wang, Gang Chen, Rongling Wu

Serum vitamin D levels and survival of patients with colorectal cancer: Post-hoc analysis of a prospective cohort study

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Research article

Hidetoshi Mezawa, Tsutomu Sugiura, Michiaki Watanabe, Chihiro Norizoe, Daisuke Takahashi, Akira Shimojima, Seryna Tamez, Yusuke Tsutsumi, Katsuhiko Yanaga, Mitsuyoshi Urashima

Myc suppression of Nfkb2 accelerates lymphomagenesis

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Research article

Ulrich Keller, Jürgen Huber, Jonas A Nilsson, Mohammad Fallahi, Mark A Hall, Christian Peschel, John L Cleveland

Clostridium perfringens enterotoxin carboxy-terminal fragment is a novel tumor-homing peptide for human ovarian cancer

Open Access
Research article

Emiliano Cocco, Francesca Casagrande, Stefania Bellone, Christine E Richter, Marta Bellone, Paola Todeschini, Jennie C Holmberg, Han Hsuan Fu, Michele K Montagna, Gil Mor, Peter E Schwartz, Dan Arin-Silasi, Masoud Azoudi, Thomas J Rutherford, Maysa Abu-Khalaf, Sergio Pecorelli, Alessandro D Santin

Cyclin H expression is increased in GIST with very-highrisk of malignancy

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Research article

Julian Dorn, Hanno Spatz, Michael Schmieder, Thomas FE Barth, Annette Blatz, Doris Henne-Bruns, Uwe Knippschild, Klaus Kramer

Characterization of the apoptotic response of human leukemia cells to organosulfur compounds

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Research article

W Wei-Lynn Wong, Paul C Boutros, Amanda R Wasylishen, Kristal D Guckert, Erin M O'Brien, Rebecca Griffiths, Anna R Martirosyan, Christina Bros, Igor Jurisica, Richard F Langler, Linda Z Penn

Decreased expression of GST pi is correlated with a poor prognosis in human esophageal squamous carcinoma

Open Access
Research article

Zhihui Wang, Wei He, Guanrui Yang, Junsheng Wang, Zhong Wang, Jahn M Nesland, Ruth Holm, Zhenhe Suo

Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions

Open Access
Research article

Flora Zagouri, Theodoros N Sergentanis, Afrodite Nonni, Christos A Papadimitriou, Nikolaos V Michalopoulos, Philip Domeyer, George Theodoropoulos, Andreas Lazaris, Effstratios Patsouris, Eleni Zogafos, Anastazia Pazaiti, George C Zografos

miR-183 inhibits TGF-β1-induced apoptosis by downregulation of PDCD4 expression in human hepatocellular carcinoma cells

Open Access
Research article

Jipeng Li, Hanjiang Fu, Chengwang Xu, Yi Tie, Ruiyun Xing, Jie Zhu, Yide Qin, Zhixian Sun, Xiaofei Zheng

Determinants of participation in colonoscopic screening by siblings of colorectal cancer patients in France

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Research article

Myriam Taouqi, Isabelle Ingrand, Michel Beauchant, Virginie Migeot, Pierre Ingrand

Up-regulation and subcellular localization of hnRNP A2/B1 in the development of hepatocellular carcinoma

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Research article

Huaqing Cui, Feng Wu, Yanling Sun, Guocai Fan, Qingming Wang

The epidemiology of bone cancer in 0 - 39 year olds in northern England, 1981 - 2002

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Research article

Rachel Eyre, Richard G Feltbower, Peter W James, Karen Blakey, Emmanuel Mubwandarikwa, David Forman, Patricia A McKinney, Mark S Pearce, Richard JQ McNally

Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factors

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Research article

JiaJia Huang, WenQi Jiang, RuiHua Xu, HuiQiang Huang, Yue Lv, ZhongJun Xia, XiaoFei Sun, ZhongZhen Guan, TongYu Lin, ZhiMing Li

Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen

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Research article

Caiyun Liu, Bin Dong, Aiping Lu, Like Qu, Xiaofang Xing, Lin Meng, Jian Wu, Y Eric Shi, Chengchao Shou

Gorlin syndrome associated with small bowel carcinoma and mesenchymal proliferation of the gastrointestinal tract: case report and review of literature

Open Access
Case report

Peter M Prodinger, Mario Sarbia, Jörg Maßmann, Christian Straka, Günther Meyer, Ortrud K Steinlein

Distress and quality of life after autologous stem cell transplantation: a randomized clinical trial to evaluate the outcome of a web-based stepped care intervention

Open Access
Study protocol

Annemarie MJ Braamse, Berno van Meijel, Otto Visser, Patricia van Oppen, Annette D Boenink, Corien Eeltink, Pim Cuijpers, Peter C Huijgens, Aartjan TF Beekman, Joost Dekker

Cryopreservation of human colorectal carcinomas prior to xenografting

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Research article

Michael Linnebacher, Claudia Maletzki, Christiane Ostwald, Ulrike Klier, Mathias Krohn, Ernst Klar, Friedrich Prall

Molecular, cellular and physiological characterization of the cancer cachexia-inducing C26 colon carcinoma in mouse

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Research article

Paola Aulino, Emanuele Berardi, Veronica M Cardillo, Emanuele Rizzuto, Barbara Perniconi, Carla Ramina, Fabrizio Padula, Enrico P Spugnini, Alfonso Baldi, Fabio Faiola, Sergio Adamo, Dario Coletti

Development of a highly metastatic model that reveals a crucial role of fibronectin in lung cancer cell migration and invasion

Open Access
Research article

Deshui Jia, Mingxia Yan, Xiaomin Wang, Xiangfang Hao, Linhui Liang, Lei Liu, Hanwei Kong, Xianghuo He, Jinjun Li, Ming Yao

Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma

Open Access
Research article

Xiqiang Liu, Anxun Wang, Lorenzo Lo Muzio, Antonia Kolokythas, Shihu Sheng, Corrado Rubini, Hui Ye, Fei Shi, Tianwei Yu, David L Crowe, Xiaofeng Zhou

Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists

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Research article

David Mossman, Kyu-Tae Kim, Rodney J Scott

MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN

Open Access
Research article

Zhang Chun-zhi, Han Lei, Zhang An-ling, Fu Yan-chao, Yue Xiao, Wang Guang-xiu, Jia Zhi-fan, Pu Pei-yu, Zhang Qing-yu, Kang Chun-sheng

Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies

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Research article

Milind M Javle, Rachna T Shroff, Henry Xiong, Gauri A Varadhachary, David Fogelman, Shrikanth A Reddy, Darren Davis, Yujian Zhang, Robert A Wolff, James L Abbruzzese

Synergistic effect of stromelysin-1 (matrix metalloproteinase-3) promoter (-1171 5A->6A) polymorphism in oral submucous fibrosis and head and neck lesions

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Research article

Ajay K Chaudhary, Mamta Singh, Alok C Bharti, Mangal Singh, Shirish Shukla, Atul K Singh, Ravi Mehrotra

Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells

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Research article

Kazuhito Sasaki, Nelson H Tsuno, Eiji Sunami, Giichiro Tsurita, Kazushige Kawai, Yurai Okaji, Takeshi Nishikawa, Yasutaka Shuno, Kumiko Hongo, Masaya Hiyoshi, Manabu Kaneko, Joji Kitayama, Koki Takahashi, Hirokazu Nagawa

Can concurrent core biopsy and fine needle aspiration biopsy improve the false negative rate of sonographically detectable breast lesions?

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Research article

Yao-Lung Kuo, Tsai-Wang Chang

Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor

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Research article

Helen J Knowles, Karl-Ludwig Schaefer, Uta Dirksen, Nicholas A Athanasou

Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells

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Research article

Joanna M Poczobutt, John Tentler, Xian Lu, Pepper J Schedin, Arthur Gutierrez-Hartmann

Relationship between H.Pylori infection and clinicopathological features and prognosis of gastric cancer

Open Access
Research article

Hai-Bo Qiu, Li-Yi Zhang, Rajiv-Prasad Keshari, Guo-Qiang Wang, Zhi-Wei Zhou, Da-Zhi Xu, Wei Wang, You-Qin Zhan, Wei Li

Stimulation of angiogenesis resulting from cooperation between macrophages and MDA-MB-231 breast cancer cells: proposed molecular mechanism and effect of tetrathiomolybdate

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Research article

Ulrich Joimel, Caroline Gest, Jeannette Soria, Linda-Louise Pritchard, Jérôme Alexandre, Marc Laurent, Emmanuel Blot, Lionel Cazin, Jean-Pierre Vannier, Rémi Varin, Hong Li, Claudine Soria

Relationship between EGFR expression, copy number and mutation in lung adenocarcinomas

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Research article

Zhiyong Liang, Jing Zhang, Xuan Zeng, Jie Gao, Shafei Wu, Tonghua Liu

Expression profile and specific network features of the apoptotic machinery explain relapse of acute myeloid leukemia after chemotherapy

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Research article

Marco Ragusa, Giuseppe Avola, Rosario Angelica, Davide Barbagallo, Maria Rosa Guglielmino, Laura R Duro, Alessandra Majorana, Luisa Statello, Loredana Salito, Carla Consoli, Maria Grazia Camuglia, Cinzia Di Pietro, Giuseppe Milone, Michele Purrello

Tumor suppressor genes are frequently methylated in lymph node metastases of breast cancers

Open Access
Research article

Weiwei Feng, Rosaria Orlandi, Naiqing Zhao, Maria Luisa Carcangiu, Elda Tagliabue, Jia Xu, Robert C Bast Jr, Yinhua Yu

Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer cells towards apoptosis

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Research article

Felix Rückert, Nicole Samm, Anne-Kathrin Lehner, Hans-Detlev Saeger, Robert Grützmann, Christian Pilarsky

Voltage dependent anion channel-1 regulates death receptor mediated apoptosis by enabling cleavage of caspase-8

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Research article

Alex D Chacko, Fabio Liberante, Ian Paul, Daniel B Longley, Dean A Fennell

An open cohort study of bone metastasis incidence following surgery in breast cancer patients

Open Access
Research article

Mitsuru Koizumi, Masataka Yoshimoto, Fujio Kasumi, Takuji Iwase

Toll-Like Receptor (TLR) and Nucleosome-binding Oligomerization Domain (NOD) gene polymorphisms and endometrial cancer risk

Open Access
Research article

Katie A Ashton, Anthony Proietto, Geoffrey Otton, Ian Symonds, Mark McEvoy, John Attia, Rodney J Scott

Cell type-specific anti-cancer properties of valproic acid: independent effects on HDAC activity and Erk1/2 phosphorylation

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Research article

Kamil Gotfryd, Galina Skladchikova, Eugene A Lepekhin, Vladimir Berezin, Elisabeth Bock, Peter S Walmod

Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma

Open Access
Research article

Patrick Evers, Percy P Lee, John DeMarco, Nzhde Agazaryan, James W Sayre, Michael Selch, Frank Pajonk

HIF1α isoforms in benign and malignant prostate tissue and their correlation to neuroendocrine differentiation

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Research article

Nastaran Monsef, Maria Soller, Ioannis Panagopoulos, Per Anders Abrahamsson

Gene expression analysis after receptor tyrosine kinase activation reveals new potential melanoma proteins

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Research article

Janka Teutschbein, Johannes M Haydn, Birgit Samans, Michael Krause, Martin Eilers, Manfred Schartl, Svenja Meierjohann

Histone H4 acetylation by immunohistochemistry and prognosis in newly diagnosed adult acute lymphoblastic leukemia (ALL) patients

Open Access
Research article

Anjali S Advani, Sarah E Gibson, Elizabeth Douglas, Tao Jin, Xiaoxian Zhao, Matt Kalaycio, Ed Copelan, Ronald Sobecks, Mikkael Sekeres, Shawnda Sungren, Eric D Hsi

p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance

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Research article

Ji Yeon Yang, Seon-Ah Ha, Yun-Sik Yang, Jin Woo Kim

Mutational spectrum of APC and genotype-phenotype correlations in Greek FAP patients

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Research article

Florentia Fostira, Georgia Thodi, Raphael Sandaltzopoulos, George Fountzilas, Drakoulis Yannoukakos

Troglitazone suppresses telomerase activity independently of PPARγ in estrogen-receptor negative breast cancer cells

Open Access
Research article

Fariborz Rashid-Kolvear, Michael AS Taboski, Johnny Nguyen, Dong-Yu Wang, Lea A Harrington, Susan J Done

Degradation of HER2/neu by ANT2 shRNA suppresses migration and invasiveness of breast cancer cells

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Research article

Ji-Young Jang, Yoon-Kyung Jeon, Chul-Woo Kim

Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1

Open Access
Research article

Ho-Keun Kwon, Ji-Sun Hwang, Jae-Seon So, Choong-Gu Lee, Anupama Sahoo, Jae-Ha Ryu, Won Kyung Jeon, Byoung Seob Ko, Chang-Rok Im, Sung Haeng Lee, Zee Yong Park, Sin-Hyeog Im

Short rare hTERT-VNTR2-2nd alleles are associated with prostate cancer susceptibility and influence gene expression

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Research article

Se-Lyun Yoon, Se-Il Jung, Eun-Ju Do, Se-Ra Lee, Sang-Yeop Lee, In-Sun Chu, Wun-Jae Kim, Jaeil Jung, Choung Soo Kim, Sang-Hyeon Cheon, Sun-Hee Leem

Effects of ATRA combined with citrus and ginger-derived compounds in human SCC xenografts

Open Access
Research article

Heather E Kleiner-Hancock, Runhua Shi, Angela Remeika, Delira Robbins, Misty Prince, Jennifer N Gill, Zanobia Syed, Patrick Adegboyega, J Michael Mathis, John L Clifford

Characterisation of prostate cancer lesions in heterozygous Men1 mutant mice

Open Access
Research article

Christelle Seigne, Sandra Fontanière, Christine Carreira, Jieli Lu, Wei-Ming Tong, Bernard Fontanière, Zhao-Qi Wang, Chang Xian Zhang, Lucien Frappart

Clinical array-based karyotyping of breast cancer with equivocal HER2 status resolves gene copy number and reveals chromosome 17 complexity

Open Access
Technical advance

Shelly Gunn, I-Tien Yeh, Irina Lytvak, Budi Tirtorahardjo, Natasha Dzidic, Soheila Zadeh, Jaeweon Kim, Chris McCaskill, Lony Lim, Mercedes Gorre, Mansoor Mohammed

GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer

Open Access
Research article

Kristi D Lynn, D Gomika Udugamasooriya, Christina L Roland, Diego H Castrillon, Thomas J Kodadek, Rolf A Brekken

Adjuvant radiotherapy and chemotherapy in breast cancer: 30 year follow-up of survival

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Research article

Colin S McArdle, Donald C McMillan, Nicola Greenlaw, David S Morrison

Predictive value of CpG island methylator phenotype for tumor recurrence in hepatitis B virus-associated hepatocellular carcinoma following liver transplantation

Open Access
Research article

Li-Ming Wu, Feng Zhang, Lin Zhou, Zhe Yang, Hai-Yang Xie, Shu-Sen Zheng

Variations in the quality and costs of end-of-life care, preferences and palliative outcomes for cancer patients by place of death: the QUALYCARE study

Open Access
Study protocol

Barbara Gomes, Paul McCrone, Sue Hall, Jonathan Koffman, Irene J Higginson

Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias

Open Access
Research article

Julien Rocquain, Nadine Carbuccia, Virginie Trouplin, Stéphane Raynaud, Anne Murati, Meyer Nezri, Zoulika Tadrist, Sylviane Olschwang, Norbert Vey, Daniel Birnbaum, Véronique Gelsi-Boyer, Marie-Joelle Mozziconacci

5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice

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Research article

Yongsheng Wang, Changyang Gong, Li Yang, Qinjie Wu, Shuai Shi, Huashan Shi, Zhiyong Qian, Yuquan Wei

Siah1 proteins enhance radiosensitivity of human breast cancer cells

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Research article

Hai-Tao He, Emmanouil Fokas, An You, Rita Engenhart-Cabillic, Han-Xiang An

No influence of the polymorphisms CYP2C19 and CYP2D6 on the efficacy of cyclophosphamide, thalidomide, and bortezomib in patients with Multiple Myeloma

Open Access
Research article

Annette J Vangsted, Karen Søeby, Tobias W Klausen, Niels Abildgaard, Niels F Andersen, Peter Gimsing, Henrik Gregersen, Ulla Vogel, Thomas Werge, Henrik B Rasmussen

Extramammary Paget's disease with the appearance of a nodule: a case report

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Case report

Xia Wang, Wenlin Yang, Jian Yang

Physical activity interventions to improve daily walking activity in cancer survivors

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Research article

Ruud H Knols, Eling D de Bruin, Kei Shirato, Daniel Uebelhart, Neil K Aaronson

Monozygotic twins with Neurofibromatosis type 1, concordant phenotype and synchronous development of MPNST and metastasis

Open Access
Case report

German Melean, Alba Marina Hernández, María Carmen Valero, Elisabete Hernández-Imaz, Yolanda Martín, Concepción Hernández-Chico

Simplifying the detection of MUTYH mutations by high resolution melting analysis

Open Access
Research article

Isabel López-Villar, Rosa Ayala, Jan Wesselink, Juan Diego Morillas, Elena López, José Carlos Marín, José Díaz-Tasende, Sara González, Luis Robles, Joaquín Martínez-López

Decreased Hsp90 expression in infiltrative lobular carcinoma: an immunohistochemical study

Open Access
Research article

Flora Zagouri, Theodoros Sergentanis, Afrodite Nonni, Christos Papadimitriou, Anastasia Pazaiti, Nikolaos V Michalopoulos, Panagiotis Safioleas, Andreas Lazaris, George Theodoropoulos, Effstratios Patsouris, George Zografos

Mass spectrometry protein expression profiles in colorectal cancer tissue associated with clinico-pathological features of disease

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Research article

Christopher CL Liao, Nicholas Ward, Simon Marsh, Tan Arulampalam, John D Norton

SLUG/SNAI2 and Tumor Necrosis Factor Generate Breast Cells With CD44+/CD24- Phenotype

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Poornima Bhat-Nakshatri, Hitesh Appaiah, Christopher Ballas, Patricia Pick-Franke, Robert Goulet Jr, Sunil Badve, Edward F Srour, Harikrishna Nakshatri

In vitro effects of imatinib mesylate on radiosensitivity and chemosensitivity of breast cancer cells

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Marion T Weigel, Linda Dahmke, Christian Schem, Dirk O Bauerschlag, Katrin Weber, Peter Niehoff, Maret Bauer, Alexander Strauss, Walter Jonat, Nicolai Maass, Christoph Mundhenke

Mutations in the WTX- gene are found in some high-grade microsatellite instable (MSI-H) colorectal cancers

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Silvio K Scheel, Marc Porzner, Sabine Pfeiffer, Steffen Ormanns, Thomas Kirchner, Andreas Jung

Nuclear β-catenin and CD44 upregulation characterize invasive cell populations in non-aggressive MCF-7 breast cancer cells

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Masahiro Uchino, Hiroko Kojima, Kenta Wada, Mika Imada, Fumitoshi Onoda, Hiroyuki Satofuka, Takahiko Utsugi, Yasufumi Murakami

TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients

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Chao Wang, Shouqiang Cao, Ying Yan, Qiao Ying, Tao Jiang, Ke Xu, Anhua Wu

Prognostic significance of lymphangiogenesis in pharyngolaryngeal carcinoma patients

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Darío Garcia-Carracedo, Juan Pablo Rodrigo, Aurora Astudillo, Carlos Suarez Nieto, Maria Victoria Gonzalez

Restoration of radiation therapy-induced salivary gland dysfunction in mice by post therapy IGF-1 administration

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Oliver Grundmann, Jamia L Fillinger, Kerton R Victory, Randy Burd, Kirsten H Limesand

Survivin gene silencing sensitizes prostate cancer cells to selenium growth inhibition

Open Access
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Xichun Liu, Ruijuan Gao, Yan Dong, Lifang Gao, Yanying Zhao, Lijuan Zhao, Xuejian Zhao, Haitao Zhang

Involvement of tumor necrosis factor-α in the upregulation of CXCR4 expression in gastric cancer induced by Helicobacter pylori

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Chenghai Zhao, Xiaomei Lu, Xianmin Bu, Ning Zhang, Wei Wang

Variant alleles of the CYP1B1 gene are associated with colorectal cancer susceptibility

Open Access
Research article

Joanna Trubicka, Ewa Grabowska-Kłujszo, Janina Suchy, Bartłomiej Masojć, Pablo Serrano-Fernandez, Grzegorz Kurzawski, Cezary Cybulski, Bohdan Górski, Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Elżbieta Złowocka, Józef Kładny, Zbigniew Banaszkiewicz, Rafał Wiśniowski, Elżbieta Kowalska, Jan Lubinski, Rodney J Scott

Cancer type-specific modulation of mitochondrial haplogroups in breast, colorectal and thyroid cancer

Open Access
Research article

Hezhi Fang, Lijun Shen, Tao Chen, Jing He, Zhinan Ding, Jia Wei, Jianchun Qu, Guorong Chen, Jianxin Lu, Yidong Bai

Combined effects of cigarette smoking, gene polymorphisms and methylations of tumor suppressor genes on non small cell lung cancer: a hospital-based case-control study in China

Open Access
Research article

Yongtang Jin, Heyun Xu, Chunye zhang, Yunming Kong, Yong Hou, Yingchun Xu, Shaoli Xue

Post-operative breast cancer patients diagnosed with skeletal metastasis without bone pain had fewer skeletal-related events and deaths than those with bone pain

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Mitsuru Koizumi, Masataka Yoshimoto, Fujio Kasumi, Takuji Iwase, Etsuro Ogata

Impact of adjuvant chemotherapy for gliomatosis cerebri

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Doo-Sik Kong, Sung Tae Kim, Jung-Il Lee, Yeon-Lim Suh, Do Hoon Lim, Won Seog Kim, Ki-Hoon Kwon, Kwan Park, Jong Hyun Kim, Do-Hyun Nam

LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells

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Jung-Young Shin, Jeong-Oh Kim, Suk Kyeong Lee, Hiun-Suk Chae, Jin-Hyoung Kang

Distinguishing between cancer driver and passenger gene alteration candidates via cross-species comparison: a pilot study

Open Access
Research article

Xinglai Ji, Jie Tang, Richard Halberg, Dana Busam, Steve Ferriera, Maria Marjorette O Peña, Chinnambally Venkataramu, Timothy J Yeatman, Shaying Zhao

Human Sulfatase 2 inhibits in vivo tumor growth of MDA-MB-231 human breast cancer xenografts

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Research article

Sarah M Peterson, Andrea Iskenderian, Lynette Cook, Alla Romashko, Kristen Tobin, Michael Jones, Angela Norton, Alicia Gómez-Yafal, Michael W Heartlein, Michael F Concino, Lucy Liaw, Paolo GV Martini

Downregulation of metastasis suppressor 1(MTSS1) is associated with nodal metastasis and poor outcome in Chinese patients with gastric cancer

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Ke Liu, Gefang Wang, Houzhong Ding, Ying Chen, Guanzhen Yu, Jiejun Wang

Sperm protein 17 is highly expressed in endometrial and cervical cancers

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Fang-qiu Li, Qun Liu, Yan-ling Han, Bo Wu, Hong-lin Yin

Final results of a phase I/II pilot study of capecitabine with or without vinorelbine after sequential dose-dense epirubicin and paclitaxel in high-risk early breast cancer

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Research article

Volkmar Müller, Christoph Thomssen, Marcus Schmidt, Manfred Glados, Christian Jackisch, Volker Heilmann, Axel Hinke, Antje Lehnert, Henryk Borowicz, Volker Möbus

Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy

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Research article

Xiaoxiang Guan, Ming Yin, Qingyi Wei, Hui Zhao, Zhensheng Liu, Li-E Wang, Xianglin Yuan, Michael S O'Reilly, Ritsuko Komaki, Zhongxing Liao

Analysis of genetic copy number changes in cervical disease progression

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Frank A Policht, Minghao Song, Svetlana Sitailo, Anna O'Hare, Raheela Ashfaq, Carolyn Y Muller, Larry E Morrison, Walter King, Irina A Sokolova

Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models

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Research article

Siver A Moestue, Eldrid Borgan, Else M Huuse, Evita M Lindholm, Beathe Sitter, Anne-Lise Børresen-Dale, Olav Engebraaten, Gunhild M Mælandsmo, Ingrid S Gribbestad

Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues

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Research article

Georgios Boukakis, Meropi Patrinou-Georgoula, Maria Lekarakou, Christos Valavanis, Apostolia Guialis

Mechanism of endothelial progenitor cell recruitment into neo-vessels in adjacent non-tumor tissues in hepatocellular carcinoma

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De-cai Yu, Jun Chen, Xi-tai Sun, Lin-yuan Zhuang, Chun-ping Jiang, Yi-tao Ding

Systematic Review of topotecan (Hycamtin) in relapsed small cell lung cancer

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Research article

Rob Riemsma, Jean P Simons, Zahid Bashir, Caroline L Gooch, Jos Kleijnen

Correlation of NF-κB signal pathway with tumor metastasis of human head and neck squamous cell carcinoma

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Research article

Ming Yan, Qin Xu, Ping Zhang, Xiao-jian Zhou, Zhi-yuan Zhang, Wan-tao Chen

Imatinib induced severe skin reactions and neutropenia in a patient with gastrointestinal stromal tumor

Open Access
Case report

Jun-Eul Hwang, Ju-Young Yoon, Woo-Kyun Bae, Hyun-Jeong Shim, Sang-Hee Cho, Ik-Joo Chung

Rapid method for determination of DNA repair capacity in human peripheral blood lymphocytes amongst smokers

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Randa A El-Zein, Claudia M Monroy, Andrea Cortes, Margaret R Spitz, Anthony Greisinger, Carol J Etzel

Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells

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Research article

Jan N Kreutzer, Maria Ruzzene, Barbara Guerra

In vitro study on the schedule-dependency of the interaction between pemetrexed, gemcitabine and irradiation in non-small cell lung cancer and head and neck cancer cells

Open Access
Research article

An Wouters, Bea Pauwels, Filip Lardon, Greet GO Pattyn, Hilde AJ Lambrechts, Marc Baay, Paul Meijnders, Jan B Vermorken

Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase

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Nikolaos Stefanou, Vassilis Papanikolaou, Yoichi Furukawa, Yusuke Nakamura, Aspasia Tsezou

The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion

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Research article

Daisuke Fujimoto, Yasuo Hirono, Takanori Goi, Kanji Katayama, Shigeru Matsukawa, Akio Yamaguchi

Human mammary fibroblasts stimulate invasion of breast cancer cells in a three-dimensional culture and increase stroma development in mouse xenografts

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Charlotta J Olsen, José Moreira, Eugene M Lukanidin, Noona S Ambartsumian

Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response

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Research article

Ying Yan, Yan-Yan Gao, Bao-Qin Liu, Xiao-Fang Niu, Ying Zhuang, Hua-Qin Wang

Traditional Cantonese diet and nasopharyngeal carcinoma risk: a large-scale case-control study in Guangdong, China

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Research article

Wei-Hua Jia, Xiang-Yu Luo, Bing-Jian Feng, Hong-Lian Ruan, Jin-Xin Bei, Wen-Sheng Liu, Hai-De Qin, Qi-Sheng Feng, Li-Zhen Chen, Shugart Yin Yao, Yi-Xin Zeng

An investigation of breast cancer risk factors in Cyprus: a case control study

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Andreas Hadjisavvas, Maria A Loizidou, Nicos Middleton, Thalia Michael, Rena Papachristoforou, Eleni Kakouri, Maria Daniel, Panayiotis Papadopoulos, Simon Malas, Yiola Marcou, Kyriacos Kyriacou

Biological characteristics and treatment outcomes of metastatic or recurrent neuroendocrine tumors: tumor grade and metastatic site are important for treatment strategy

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Su-Jung Kim, Jin Won Kim, Sae-Won Han, Do-Youn Oh, Se-Hoon Lee, Dong-Wan Kim, Seock-Ah Im, Tae-You Kim, Dae Seog Heo, Yung-Jue Bang

Phenotyping breast cancer cell lines EM-G3, HCC1937, MCF7 and MDA-MB-231 using 2-D electrophoresis and affinity chromatography for glutathione-binding proteins

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Jana Mladkova, Miloslav Sanda, Eva Matouskova, Irena Selicharova

Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept

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Stefan Rieken, Timo Gaiser, Angela Mohr, Thomas Welzel, Olaf Witt, Andreas E Kulozik, Wolfgang Wick, Jürgen Debus, Stephanie E Combs

Detecting acute neurotoxicity during platinum chemotherapy by neurophysiological assessment of motor nerve hyperexcitability

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Andrew Hill, Peter Bergin, Fritha Hanning, Paul Thompson, Michael Findlay, Dragan Damianovich, Mark J McKeage

Diagnostic and treatment pathways for men with prostate cancer in Queensland: investigating spatial and demographic inequalities

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Study protocol

Peter D Baade, Joanne F Aitken, Megan Ferguson, Robert A Gardiner, Suzanne K Chambers

Factors associated with cancer-related fatigue in breast cancer patients undergoing endocrine therapy in an urban setting: a cross-sectional study

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Xu Huang, Qingyuan Zhang, Xinmei Kang, Ying Song, Wenhui Zhao

Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas

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Research article

Juan L Garcia, Maria Perez-Caro, Juan A Gomez-Moreta, Francisco Gonzalez, Javier Ortiz, Oscar Blanco, Magdalena Sancho, Jesus M Hernandez-Rivas, Rogelio Gonzalez-Sarmiento, Manuel Sanchez-Martin

Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers

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Research article

Henne Holstege, Erik van Beers, Arno Velds, Xiaoling Liu, Simon A Joosse, Sjoerd Klarenbeek, Eva Schut, Ron Kerkhoven, Christiaan N Klijn, Lodewyk FA Wessels, Petra M Nederlof, Jos Jonkers

Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese

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Research article

Jie Liu, Bao Song, Xueli Bai, Wenjian Liu, Zengjun Li, Jialin Wang, Yan Zheng, Zhehai Wang

Thymostimulin versus placebo for palliative treatment of locally advanced or metastasised hepatocellular carcinoma: a phase III clinical trial

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Research article

Matthias M Dollinger, Christine Lautenschlaeger, Joachim Lesske, Andrea Tannapfel, Anna-Dorothea Wagner, Konrad Schoppmeyer, Oliver Nehls, Martin-Walter Welker, Reiner Wiest, Wolfgang E Fleig

Molecular alterations in key-regulator genes among patients with T4 breast carcinoma

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Research article

Bruno Massidda, MariaCristina Sini, Mario Budroni, Francesco Atzori, MariaCristina Deidda, Valeria Pusceddu, MariaTeresa Perra, Paola Sirigu, Antonio Cossu, Grazia Palomba, MariaTeresa Ionta, Giuseppe Palmieri

The PI3K/Akt pathway upregulates Id1 and integrin α4 to enhance recruitment of human ovarian cancer endothelial progenitor cells

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Yajuan Su, Lei Zheng, Qian Wang, Jie Bao, Zhen Cai, Ailan Liu

Integration of transcript expression, copy number and LOH analysis of infiltrating ductal carcinoma of the breast

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Lesleyann Hawthorn, Jesse Luce, Leighton Stein, Jenniffer Rothschild

Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC

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Research article

Zhong-Zhe Lin, Yung-Ming Jeng, Fu-Chang Hu, Hung-Wei Pan, Hsin-Wei Tsao, Po-Lin Lai, Po-Huang Lee, Ann-Lii Cheng, Hey-Chi Hsu

Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of Bone

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Research article

Maurice Balke, Laura Campanacci, Carsten Gebert, Piero Picci, Max Gibbons, Richard Taylor, Pancras Hogendoorn, Judith Kroep, John Wass, Nicholas Athanasou

CYP1A1gene polymorphisms increase lung cancer risk in a high-incidence region of Spain: a case control study

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Research article

Carmen San Jose, Agustin Cabanillas, Julio Benitez, Juan Antonio Carrillo, Mercedes Jimenez, Guillermo Gervasini

COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function

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Research article

Joris D Veltman, Margaretha EH Lambers, Menno van Nimwegen, Rudi W Hendriks, Henk C Hoogsteden, Joachim GJV Aerts, Joost PJJ Hegmans

Does the use of the 2009 FIGO classification of endometrial cancer impact on indications of the sentinel node biopsy?

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Research article

Marcos Ballester, Martin Koskas, Charles Coutant, Elisabeth Chéreau, Jeremy Seror, Roman Rouzier, Emile Daraï

Comparing the frequency of common genetic variants and haplotypes between carriers and non-carriers of BRCA1 and BRCA2deleterious mutations in Australian women diagnosed with breast cancer before 40 years of age

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Lidija Turkovic, Lyle C Gurrin, Melanie Bahlo, Gillian S Dite, Melissa C Southey, John L Hopper

Prognostic relevance of Bmi-1 expression and autoantibodies in esophageal squamous cell carcinoma

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Research article

Wan-li Liu, Xian-zhi Guo, Lan-jun Zhang, Jun-ye Wang, Ge Zhang, Su Guan, Yu-min Chen, Qing-li Kong, Li-hua Xu, Man-zhi Li, Li-bing Song, Mu-sheng Zeng

MRP3: a molecular target for human glioblastoma multiforme immunotherapy.

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Chien-Tsun Kuan, Kenji Wakiya, James E Herndon II, Eric S Lipp, Charles N Pegram, Gregory J Riggins, Ahmed Rasheed, Scott E Szafranski, Roger E McLendon, Carol J Wikstrand, Darell D Bigner

Validation and use of microdialysis for determination of pharmacokinetic properties of the chemotherapeutic agent mitomycin C - an experimental study

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Olaf Sørensen, Anders Andersen, Harald Olsen, Kristian Alexandr, Per Olaf Ekstrøm, Karl-Erik Giercksky, Kjersti Flatmark

Promoter methylation and large intragenic rearrangements of DPYD are not implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients

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Research article

Joana Savva-Bordalo, João Ramalho-Carvalho, Manuela Pinheiro, Vera L Costa, Ângelo Rodrigues, Paula C Dias, Isabel Veiga, Manuela Machado, Manuel R Teixeira, Rui Henrique, Carmen Jerónimo

Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors

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Research article

Christopher A Hamm, Jeff W Stevens, Hehuang Xie, Elio F Vanin, Jose A Morcuende, Hakeem Abdulkawy, Elisabeth A Seftor, Simone T Sredni, Jared M Bischof, Deli Wang, Sergey Malchenko, Maria de Fatima Bonaldo, Thomas L Casavant, Mary JC Hendrix, Marcelo B Soares

MRS-guided HDR brachytherapy boost to the dominant intraprostatic lesion in high risk localised prostate cancer

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Technical advance

Aleksandra Kazi, Guy Godwin, John Simpson, Giuseppe Sasso

p21Waf1 expression is regulated by nuclear intermediate filament vimentin in neuroblastoma

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Research article

Xénia Mergui, Marie-Line Puiffe, Dominique Valteau-Couanet, Marc Lipinski, Jean Bénard, Mounira Amor-Guéret

Relationship between tumor size and disease stage in non-small cell lung cancer

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Research article

Fu Yang, Haiquan Chen, Jiaqing Xiang, Yawei Zhang, Jianhua Zhou, Hong Hu, Jie Zhang, Xiaoyang Luo

Long-term effect of stereotactic body radiation therapy for primary hepatocellular carcinoma ineligible for local ablation therapy or surgical resection. Stereotactic radiotherapy for liver cancer

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Research article

Jung Hyun Kwon, Si Hyun Bae, Ji Yoon Kim, Byung Ock Choi, Hong Seok Jang, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon, Kyu Won Chung

Large-scale proteomic identification of S100 proteins in breast cancer tissues

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Research article

Patrizia Cancemi, Gianluca Di Cara, Nadia Ninfa Albanese, Francesca Costantini, Maria Rita Marabeti, Rosa Musso, Carmelo Lupo, Elena Roz, Ida Pucci-Minafra

Expression of CIAPIN1 in human colorectal cancer and its correlation with prognosis

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Research article

Hai Shi, Yi Zhou, Heliang Liu, Changsheng Chen, Shujun Li, Nanlin Li, Xiaohua Li, Xi Zhang, Hongwei Zhang, Weizhong Wang, Qingchuan Zhao

Randomized phase II study evaluating a carbon ion boost applied after combined radiochemotherapy with temozolomide versus a proton boost after radiochemotherapy with temozolomide in patients with primary glioblastoma: The CLEOPATRA Trial

Open Access
Study protocol

Stephanie E Combs, Meinhard Kieser, Stefan Rieken, Daniel Habermehl, Oliver Jäkel, Thomas Haberer, Anna Nikoghosyan, Renate Haselmann, Andreas Unterberg, Wolfgang Wick, Jürgen Debus

Internal mammary lymph node recurrence: rare but characteristic metastasis site in breast cancer

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Research article

Lei Chen, Yajia Gu, Shiangjiin Leaw, Zhonghua Wang, Peihua Wang, Xichun Hu, Jiayi Chen, Jingsong Lu, Zhimin Shao

Extracerebral metastases determine the outcome of patients with brain metastases from renal cell carcinoma

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Research article

Ursula M Vogl, Marija Bojic, Wolfgang Lamm, Josa M Frischer, Oskar Pichelmayer, Gero Kramer, Andrea Haitel, Klaus Kitz, Kaan Harmankaya, Christoph C Zielinski, Manuela Schmidinger

17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells

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Research article

Panagiotis K Karkoulis, Dimitrios J Stravopodis, Lukas H Margaritis, Gerassimos E Voutsinas

Differential detection of alternatively spliced variants of Ciz1 in normal and cancer cells using a custom exon-junction microarray

Open Access
Research article

Faisal A Rahman, Naveed Aziz, Dawn Coverley

Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions

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Research article

Nair Lopes, Bárbara Sousa, Diana Martins, Madalena Gomes, Daniella Vieira, Luiz A Veronese, Fernanda Milanezi, Joana Paredes, José L Costa, Fernando Schmitt

Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes

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Vibeke Andersen, Jane Christensen, Kim Overvad, Anne Tjønneland, Ulla Vogel

Evaluation of mammographic density patterns: reproducibility and concordance among scales

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Research article

Macarena Garrido-Estepa, Francisco Ruiz-Perales, Josefa Miranda, Nieves Ascunce, Isabel González-Román, Carmen Sánchez-Contador, Carmen Santamariña, Pilar Moreo, Carmen Vidal, Mercé Peris, María P Moreno, Jose A Váquez-Carrete, Francisca Collado-García, Francisco Casanova, María Ederra, Dolores Salas, Marina Pollán

Expression of RNA interference triggers from an oncolytic herpes simplex virus results in specific silencing in tumour cells in vitro and tumours in vivo

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Research article

Anna-Maria Anesti, Guy R Simpson, Toby Price, Hardev S Pandha, Robert S Coffin

Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+

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Research article

Joshua C Doloff, Ting Su, David J Waxman

PGF2α-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer

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Research article

Margaret C Keightley, Kurt J Sales, Henry N Jabbour

Brain natriuretic peptide precursor (NT-pro-BNP) levels predict for clinical benefit to sunitinib treatment in patients with metastatic renal cell carcinoma

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Research article

Konstantinos T Papazisis, Lukas F Kontovinis, Christos N Papandreou, George Kouvatseas, Christos Lafaras, Evangelos Antonakis, Maria Christopoulou, Charalambos Andreadis, Despoina Mouratidou, Alexandros H Kortsaris

Transcriptional profiling of ErbB signalling in mammary luminal epithelial cells - interplay of ErbB and IGF1 signalling through IGFBP3 regulation

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Research article

Jenny Worthington, Mariana Bertani, Hong-Lin Chan, Bertran Gerrits, John F Timms

The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas

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Research article

Christian Senft, Margareth Polacin, Maike Priester, Volker Seifert, Donat Kögel, Jakob Weissenberger

Determining the role of external beam radiotherapy in unresectable intrahepatic cholangiocarcinoma: a retrospective analysis of 84 patients

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Research article

Yi-Xing Chen, Zhao-Chong Zeng, Zhao-You Tang, Jia Fan, Jian Zhou, Wei Jiang, Meng-Su Zeng, Yun-Shan Tan

Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation

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Research article

Manohar Pradhan, Björn Å Risberg, Claes G Tropé, Matt van de Rijn, C Blake Gilks, Cheng-Han Lee

Thrombospondin-4 is a putative tumour-suppressor gene in colorectal cancer that exhibits age-related methylation

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Research article

Sonia A Greco, June Chia, Kelly J Inglis, Sarah-Jane Cozzi, Ingunn Ramsnes, Ronald L Buttenshaw, Kevin J Spring, Glen M Boyle, Daniel L Worthley, Barbara A Leggett, Vicki LJ Whitehall

Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy

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Research article

Guanglin Liu, Haiqing Zheng, Zhibing Zhang, Zhiqiang Wu, Huaping Xiong, Jun Li, Libing Song

Co-expression of nuclear and cytoplasmic HMGB1 is inversely associated with infiltration of CD45RO+ T cells and prognosis in patients with stage IIIB colon cancer

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Research article

Rui-Qing Peng, Xiao-Jun Wu, Ya Ding, Chun-Yan Li, Xing-Juan Yu, Xing Zhang, Zhi-Zhong Pan, De-Sen Wan, Li-Ming Zheng, Yi-Xin Zeng, Xiao-Shi Zhang

MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

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Research article

Jennifer A Byrne, Sanaz Maleki, Jayne R Hardy, Brian S Gloss, Rajmohan Murali, James P Scurry, Susan Fanayan, Catherine Emmanuel, Neville F Hacker, Robert L Sutherland, Anna deFazio, Philippa M O'Brien

Increased serum levels of tumour-associated trypsin inhibitor independently predict a poor prognosis in colorectal cancer patients

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Research article

Alexander Gaber, Björn Nodin, Kristina Hotakainen, Elise Nilsson, Ulf-Håkan Stenman, Anders Bjartell, Helgi Birgisson, Karin Jirström

Involvement of hyaluronidases in colorectal cancer

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Research article

Helen Bouga, Isidoros Tsouros, Dimitrios Bounias, Dora Kyriakopoulou, Michael S Stavropoulos, Nikoletta Papageorgakopoulou, Dimitrios A Theocharis, Demitrios H Vynios

Knowledge and attitudes of primary health care physicians and nurses with regard to population screening for colorectal cancer in Balearic Islands and Barcelona

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Research article

Maria Ramos, Magdalena Esteva, Jesús Almeda, Elena Cabeza, Diana Puente, Rosa Saladich, Albert Boada, Maria Llagostera

Tumour stromal cells derived from paediatric malignancies display MSC-like properties and impair NK cell cytotoxicity

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Research article

Pascal-David Johann, Martin Vaegler, Friederike Gieseke, Philippa Mang, Sorin Armeanu-Ebinger, Torsten Kluba, Rupert Handgretinger, Ingo Müller

Dysregulated miR-183 inhibits migration in breast cancer cells

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Research article

Aoife J Lowery, Nicola Miller, Roisin M Dwyer, Michael J Kerin

Fibronectin 1 mRNA expression correlates with advanced disease in renal cancer

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Research article

Sandra Waalkes, Faranaz Atschekzei, Mario W Kramer, Jörg Hennenlotter, Gesa Vetter, Jan U Becker, Arnulf Stenzl, Axel S Merseburger, Andres J Schrader, Markus A Kuczyk, Jürgen Serth

Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation of hERG1 channels and of the VEGF-A pathway

Open Access
Case report

Pina Fortunato, Serena Pillozzi, Angela Tamburini, Liliana Pollazzi, Alessandro Franchi, Agostino La Torre, Annarosa Arcangeli

Changes in cortical cytoskeletal and extracellular matrix gene expression in prostate cancer are related to oncogenic ERG deregulation

Open Access
Research article

Wolfgang A Schulz, Marc Ingenwerth, Carolle E Djuidje, Christiane Hader, Jörg Rahnenführer, Rainer Engers

Expression profiling in canine osteosarcoma: identification of biomarkers and pathways associated with outcome

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Research article

Liza E O'Donoghue, Andrey A Ptitsyn, Debra A Kamstock, Janet Siebert, Russell S Thomas, Dawn L Duval

Triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival

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Research article

Yoon-La Choi, Ensel Oh, Sarah Park, Yeonju Kim, Yeon-Hee Park, Kyoung Song, Eun Yoon Cho, Yun-Chul Hong, Jong Sun Choi, Jeong Eon Lee, Jung Han Kim, Seok Jin Nam, Young-Hyuck Im, Jung-Hyun Yang, Young Kee Shin

Predictive factors of radiation-induced skin toxicity in breast cancer patients

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Research article

Miao-Fen Chen, Wen-Cheng Chen, Chia-Hsuan Lai, Chao-hsiung Hung, Kuo-Chi Liu, Yin-Hsuan Cheng

Hyperbolastic modeling of tumor growth with a combined treatment of iodoacetate and dimethylsulphoxide

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Research article

Wayne M Eby, Mohammad A Tabatabai, Zoran Bursac

Esophageal cancer in the elderly: an analysis of the factors associated with treatment decisions and outcomes

Open Access
Research article

David Tougeron, Hadji Hamidou, Michel Scotté, Frédéric Di Fiore, Michel Antonietti, Bernard Paillot, Pierre Michel

Cytochrome 450 1B1 (CYP1B1) polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC) patients

Open Access
Research article

Ilaria Pastina, Elisa Giovannetti, Aldo Chioni, Tristan M Sissung, Francesco Crea, Cinzia Orlandini, Douglas K Price, Claudia Cianci, William D Figg, Sergio Ricci, Romano Danesi

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

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Research article

Timo K Nykopp, Kirsi Rilla, Markku I Tammi, Raija H Tammi, Reijo Sironen, Kirsi Hämäläinen, Veli-Matti Kosma, Seppo Heinonen, Maarit Anttila

FLT3mutation incidence and timing of origin in a population case series of pediatric leukemia

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Patrick Chang, Michelle Kang, Anny Xiao, Jeffrey Chang, James Feusner, Patricia Buffler, Joseph Wiemels

Bone marrow transplantation in AML, and socioeconomic class: a UK population-based cohort study

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Fatima Bhayat, Emma Das-Gupta, Richard Hubbard

Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts

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Qing Chang, Mark S Chapman, Jeffrey N Miner, David W Hedley

Clinical characteristics and outcomes of patients with acute myelogenous leukemia admitted to intensive care: a case-control study

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Amanda L Roze des Ordons, Kris Chan, Imran Mirza, Derek R Townsend, Sean M Bagshaw

Epigenetic regulation of CD44in Hodgkin and non-Hodgkin lymphoma

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Sonja Eberth, Björn Schneider, Andreas Rosenwald, Elena M Hartmann, Julia Romani, Margarete Zaborski, Reiner Siebert, Hans G Drexler, Hilmar Quentmeier

A novel spliced fusion of MLL with CT45A2in a pediatric biphenotypic acute leukemia

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Nuno Cerveira, Claus Meyer, Joana Santos, Lurdes Torres, Susana Lisboa, Manuela Pinheiro, Susana Bizarro, Cecília Correia, Lucília Norton, Rolf Marschalek, Manuel R Teixeira

Carbohydrate antigens in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy

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Susan L Deutscher, Marie Dickerson, Gerald Gui, Jessica Newton, Jeffrey E Holm, Nancy Vogeltanz-Holm, Beth Kliethermes, John E Hewett, Senthil R Kumar, Thomas P Quinn, Edward R Sauter

Bilateral posterior RION after concomitant radiochemotherapy with temozolomide in a patient with glioblastoma multiforme: a case report

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Case report

Stefanie Schreiber, Vanessa Prox-Vagedes, Erck Elolf, Ines Brueggemann, Guenther Gademann, Imke Galazky, Claudius Bartels

Molecular targets for the protodynamic action of cis-urocanic acid in human bladder carcinoma cells

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Emilia Peuhu, Aura Kaunisto, Jarmo K Laihia, Lasse Leino, John E Eriksson

Association between the Cytotoxic T-Lymphocyte Antigen 4 +49G > A polymorphism and cancer risk: a meta-analysis

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Jian Zheng, Xiao Yu, Lan Jiang, Mang Xiao, Bing Bai, Jiachun Lu, Yifeng Zhou

Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients

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Yang Wang, Lei Wang, Xingwang Li, Baocheng Liu, Qingzhu Zhao, Peng Chen, Ti Wang, Tao Li, Jue Ji, Fengping Yang, Quan Wang, Jinfen Wang, Yanzeng Xiao, Yifeng Xu, Guoyin Feng, Zhihai Peng, Lin He, Guang He

Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma

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Nina Wagener, Stephan Macher-Goeppinger, Maria Pritsch, Johannes Hüsing, Karin Hoppe-Seyler, Peter Schirmacher, Jesco Pfitzenmaier, Axel Haferkamp, Felix Hoppe-Seyler, Markus Hohenfellner

SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer

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Viktor Komlósi, Erika Hitre, Éva Pap, Vilmos Adleff, Andrea Réti, Éva Székely, Anna Bíró, Péter Rudnai, Bernadette Schoket, Judit Müller, Béla Tóth, Szabolcs Ottó, Miklós Kásler, Judit Kralovánszky, Barna Budai

Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death

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Francesco Piazza, Sabrina Manni, Laura Quotti Tubi, Barbara Montini, Laura Pavan, Anna Colpo, Marianna Gnoato, Anna Cabrelle, Fausto Adami, Renato Zambello, Livio Trentin, Carmela Gurrieri, Gianpietro Semenzato

Favorable response to doxorubicin combination chemotherapy does not yield good clinical outcome in patients with metastatic breast cancer with triple-negative phenotype

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Research article

Seong Yoon Yi, Jin Seok Ahn, Ji Eun Uhm, Do Hyoung Lim, Sang Hoon Ji, Hyun Jung Jun, Kyoung Ha Kim, Myung Hee Chang, Min Jae Park, Eun Yoon Cho, Yoon La Choi, Yeon Hee Park, Young-Hyuck Im

Diagnosis delay and follow-up strategies in colorectal cancer. Prognosis implications: a study protocol

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Study protocol

Salvador Pita Fernández, Sonia Pértega Díaz, Beatriz López Calviño, Paloma González Santamaría, Teresa Seoane Pillado, Francisco Arnal Monreal, Francesc Maciá, María Antonia Sánchez Calavera, Alejandro Espí Macías, Manuel Valladares Ayerbes, Alejandro Pazos, Margarita Reboredo López, Luis González Saez, María Ramos Montserrat, Josep María Segura Noguera, Isabel Monreal Aliaga, Luis González Luján, María Martín Rabadán, Cristiane Murta Nascimento, Olga Pueyo, Marta Maia Boscá Watts, Elena Cabeza Irigoyen, Montserrat Casmitjana Abella, Marina Pinilla, Ana Costa Alcaraz, Amador Ruiz Torrejón, Andrea Burón Pust, Concepción García Aranda, María de Lluc Bennasar, Sergio Lafita Mainz, Maite Novella, Hermini Manzano, Catalina Vadell, Esther Falcó, Magdalena Esteva

Safety and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor YN968D1 in patients with advanced malignancies

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Research article

Jin Li, Xinmin Zhao, Lei Chen, Haiyi Guo, Fangfang Lv, Ka Jia, Ke Yv, Fengqing Wang, Chuan Li, Jun Qian, Chunlei Zheng, Yunxia Zuo

Genetic and epigenetic characteristics of human multiple hepatocellular carcinoma

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Kazuya Taniguchi, Terumasa Yamada, Yo Sasaki, Kikuya Kato

Rationale and design of the Exercise Intensity Trial (EXCITE): A randomized trial comparing the effects of moderate versus moderate to high-intensity aerobic training in women with operable breast cancer

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Study protocol

Lee W Jones, Pamela S Douglas, Neil D Eves, P Kelly Marcom, William E Kraus, James E Herndon II, Brant A Inman, Jason D Allen, Jeffrey Peppercorn

Robust assignment of cancer subtypes from expression data using a uni-variate gene expression average as classifier

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Software

Martin Lauss, Attila Frigyesi, Tobias Ryden, Mattias Höglund

Randomised phase I/II study to evaluate carbon ion radiotherapy versus fractionated stereotactic radiotherapy in patients with recurrent or progressive gliomas: The CINDERELLA trial

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Study protocol

Stephanie E Combs, Iris Burkholder, Lutz Edler, Stefan Rieken, Daniel Habermehl, Oliver Jäkel, Thomas Haberer, Renate Haselmann, Andreas Unterberg, Wolfgang Wick, Jürgen Debus

HER2 testing on core needle biopsy specimens from primary breast cancers: interobserver reproducibility and concordance with surgically resected specimens

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Hitoshi Tsuda, Masafumi Kurosumi, Shinobu Umemura, Sohei Yamamoto, Takayuki Kobayashi, Robert Yoshiyuki Osamura

Application of tumor-node-metastasis staging 2002 version in locally advanced hepatocellular carcinoma: is it predictive of surgical outcome?

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Binkui Li, Yunfei Yuan, Guihua Chen, Liru He, Yaqi Zhang, Jinqing Li, Guohui Li, Wan Yee Lau

Activated mammalian target of rapamycin is a potential therapeutic target in gastric cancer

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Research article

Da-zhi Xu, Qi-rong Geng, Ying Tian, Mu-yan Cai, Xin-juan Fang, You-qing Zhan, Zhi-wei Zhou, Wei Li, Ying-bo Chen, Xiao-wei Sun, Yuan-xiang Guan, Yuan-fang Li, Tong-yu Lin

Mucins in neoplastic spectrum of colorectal polyps: can they provide predictions?

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Mahsa Molaei, Babak Khoshkrood Mansoori, Reza Mashayekhi, Mohsen Vahedi, Mohamad Amin Pourhoseingholi, Seyed Reza Fatemi, Mohammad Reza Zali

LATS2 is De-methylated and Overexpressed in Nasopharyngeal Carcinoma and Predicts Poor Prognosis

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Yan Zhang, Chun-Fang Hu, Jing Chen, Li-Xu Yan, Yi-Xin Zeng, Jian-Yong Shao

Genome profiling of ERBB2-amplified breast cancers

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Fabrice Sircoulomb, Ismahane Bekhouche, Pascal Finetti, José Adélaïde, Azza Ben Hamida, Julien Bonansea, Stéphane Raynaud, Charlène Innocenti, Emmanuelle Charafe-Jauffret, Carole Tarpin, Farhat Ben Ayed, Patrice Viens, Jocelyne Jacquemier, François Bertucci, Daniel Birnbaum, Max Chaffanet

Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene

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Lisa Becks, Misty Prince, Hannah Burson, Christopher Christophe, Mason Broadway, Ken Itoh, Masayuki Yamamoto, Michael Mathis, Elysse Orchard, Runhua Shi, Jerry McLarty, Kevin Pruitt, Songlin Zhang, Heather E Kleiner-Hancock

p27Kip1deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process

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Winna Taylor, Amanda Mathias, Arshia Ali, Hengning Ke, Nikolay Stoynev, Anne Shilkaitis, Albert Green, Hiroaki Kiyokawa, Konstantin Christov

MiR-339-5p inhibits breast cancer cell migration and invasion in vitro and may be a potential biomarker for breast cancer prognosis

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Research article

Zheng-sheng Wu, Qiang Wu, Chao-qun Wang, Xiao-nan Wang, Yan Wang, Jing-jing Zhao, Shan-shan Mao, Gui-hong Zhang, Nong Zhang, Xiao-chun Xu

A profile of prognostic and molecular factors in European and Māori breast cancer patients

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Gabi U Dachs, Maiko Kano, Ekaterina Volkova, Helen R Morrin, Valerie CL Davey, Gavin C Harris, Michelle Cheale, Christopher Frampton, Margaret J Currie, J Elisabeth Wells, Bridget A Robinson

Screening of the DNA mismatch repair genes MLH1, MSH2 and MSH6in a Greek cohort of Lynch syndrome suspected families

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Georgia Thodi, Florentia Fostira, Raphael Sandaltzopoulos, George Nasioulas, Anastasios Grivas, Ioannis Boukovinas, Maria Mylonaki, Christos Panopoulos, Mirjana Brankovic Magic, George Fountzilas, Drakoulis Yannoukakos

A randomized two arm phase III study in patients post radical resection of liver metastases of colorectal cancer to investigate bevacizumab in combination with capecitabine plus oxaliplatin (CAPOX) vs CAPOX alone as adjuvant treatment

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Study protocol

Nikol Snoeren, Emile E Voest, Andre M Bergman, Otilia Dalesio, Henk M Verheul, Rob AEM Tollenaar, Joost RM van der Sijp, Sander B Schouten, Inne HM Borel Rinkes, R van Hillegersberg

Combined treatment of malignant salivary gland tumours with intensity-modulated radiation therapy (IMRT) and carbon ions: COSMIC

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Study protocol

Alexandra D Jensen, Anna Nikoghosyan, Christine Windemuth-Kieselbach, Jürgen Debus, Marc W Münter

Low salivary testosterone levels in patients with breast cancer

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Research article

Constantine Dimitrakakis, David Zava, Spyros Marinopoulos, Alexandra Tsigginou, Aris Antsaklis, Rebecca Glaser

Anti-apoptotic effect of claudin-1 in tamoxifen-treated human breast cancer MCF-7 cells

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Harue Akasaka, Fuyuki Sato, Satoko Morohashi, Yunyan Wu, Yang Liu, Jun Kondo, Hiroki Odagiri, Kenichi Hakamada, Hiroshi Kijima

SERPINB5 and AKAP12-- Expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma

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Wolf A Mardin, Kostadin O Petrov, Andreas Enns, Norbert Senninger, Joerg Haier, Soeren T Mees

PDGF-B-driven gliomagenesis can occur in the absence of the proteoglycan NG2

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Marta Terrile, Irene Appolloni, Filippo Calzolari, Roberto Perris, Evelina Tutucci, Paolo Malatesta

Study Protocol: A randomized controlled trial of patient navigation-activation to reduce cancer health disparities

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Study protocol

Samantha Hendren, Jennifer J Griggs, Ronald M Epstein, Sharon Humiston, Sally Rousseau, Pascal Jean-Pierre, Jennifer Carroll, Amanat M Yosha, Starlene Loader, Kevin Fiscella

N-terminal and C-terminal heparin-binding domain polypeptides derived from fibronectin reduce adhesion and invasion of liver cancer cells

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Nan-Hong Tang, Yan-Lin Chen, Xiao-Qian Wang, Xiu-Jin Li, Yong Wu, Qi-Lian Zou, Yuan-Zhong Chen

Expression pattern of matrix metalloproteinases in human gynecological cancer cell lines

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Andrea Schröpfer, Ulrike Kammerer, Michaela Kapp, Johannes Dietl, Sonja Feix, Jelena Anacker

The apoptotic response in HCT116 BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion protein

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Sheila J Semaan, Robert W Nickells

Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm

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Manuela Cervelli, Gabriella Bellavia, Emiliano Fratini, Roberto Amendola, Fabio Polticelli, Marco Barba, Rodolfo Federico, Fabrizio Signore, Giacomo Gucciardo, Rosalba Grillo, Patrick M Woster, Robert A Casero Jr, Paolo Mariottini

Efficacy of c-Met inhibitor for advanced prostate cancer

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William H Tu, Chunfang Zhu, Curtis Clark, James G Christensen, Zijie Sun

Triple negativity and young age as prognostic factors in lymph node-negative invasive ductal carcinoma of 1 cm or less

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Ji Hyun Kwon, Yu Jung Kim, Keun-Wook Lee, Do-Youn Oh, So Yeon Park, Jee Hyun Kim, Eui Kyu Chie, Sung-Won Kim, Seock-Ah Im, In-Ah Kim, Tae-You Kim, In Ae Park, Dong-Young Noh, Yung-Jue Bang, Sung Whan Ha

The role of concurrent chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma among endemic population: a meta-analysis of the phase iii randomized trials

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Li Zhang, Chong Zhao, Bijesh Ghimire, Ming-Huang Hong, Qing Liu, Yang Zhang, Ying Guo, Yi-Jun Huang, Zhong-Zhen Guan

Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11

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Emmalena Gregory-Bryson, Elizabeth Bartlett, Matti Kiupel, Schantel Hayes, Vilma Yuzbasiyan-Gurkan

The multikinase inhibitor Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells

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Catrin Schult, Meike Dahlhaus, Sabine Ruck, Mandy Sawitzky, Francesca Amoroso, Sandra Lange, Daniela Etro, Aenne Glass, Georg Fuellen, Sonja Boldt, Olaf Wolkenhauer, Luca Maria Neri, Mathias Freund, Christian Junghanss

Allelotyping identification of genomic alterations in rectal chromosomally unstable tumors without preoperative treatment

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Benoît Romain, Agnès Neuville, Nicolas Meyer, Cécile Brigand, Serge Rohr, Anne Schneider, Marie-Pierre Gaub, Dominique Guenot

Ras-association domain family 1C protein promotes breast cancer cell migration and attenuates apoptosis

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Mark E Reeves, Scott W Baldwin, Melissa L Baldwin, Shin-Tai Chen, Jeremy M Moretz, Robert J Aragon, Xinmin Li, Donna D Strong, Subburaman Mohan, Yousef G Amaar

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

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Daniele Campa, Anika Hüsing, James D McKay, Olga Sinilnikova, Ulla Vogel, Anne Tjønneland, Kim Overvad, Jakob Stegger, Françoise Clavel-Chapelon, Nathalie Chabbert-Buffet, Guy Fagherazzi, Antonia Trichopoulou, Dimosthenis Zylis, Erifili Oustoglou, Sabine Rohrmann, Birgit Teucher, Eva Fisher, Heiner Boeing, Giovanna Masala, Vittorio Krogh, Carlotta Sacerdote, Salvatore Panico, Rosario Tumino, N Charlotte Onland-Moret, Carla H van Gils, H Bas Bueno-de-Mesquita, Eiliv Lund, María Dolores Chirlaque, Núria Sala, José Ramon Quirós, Eva Ardanaz, Pilar Amiano, Esther Molina-Montes, Göran Hallmans, Per Lenner, Ruth C Travis, Timothy J Key, Nick Wareham, Kay-Tee Khaw, Sabina Rinaldi, Nadia Slimani, Veronique Chajes, Afshan Siddiq, Elio Riboli, Rudolf Kaaks, Federico Canzian

Comparison of thymidine phosphorylase expression and prognostic factors in gallbladder and bile duct cancer

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Hye Sung Won, Myung Ah Lee, Eun-Seon Chung, Dong-Goo Kim, Young Kyoung You, Tae Ho Hong, In-Seok Lee

Dose escalation study of an anti-thrombocytopenic agent in patients with chemotherapy induced thrombocytopenia

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Robert D Levin, MaryAnn Daehler, James F Grutsch, John L Hall, Digant Gupta, Christopher G Lis

Raloxifene inhibits tumor growth and lymph node metastasis in a xenograft model of metastatic mammary cancer

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Masa-Aki Shibata, Junji Morimoto, Eiko Shibata, Hitomi Kurose, Kanako Akamatsu, Zhong-Lian Li, Moriaki Kusakabe, Masahide Ohmichi, Yoshinori Otsuki

"Poker" association of weekly alternating 5-fluorouracil, irinotecan, bevacizumab and oxaliplatin (FIr-B/FOx) in first line treatment of metastatic colorectal cancer: a phase II study

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Research article

Gemma Bruera, Alessandra Santomaggio, Katia Cannita, Paola Lanfiuti Baldi, Marianna Tudini, Federica De Galitiis, Maria Mancini, Paolo Marchetti, Adelmo Antonucci, Corrado Ficorella, Enrico Ricevuto

Preferential antitumor effect of the Src inhibitor dasatinib associated with a decreased proportion of aldehyde dehydrogenase 1-positive cells in breast cancer cells of the basal B subtype

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Research article

Junichi Kurebayashi, Naoki Kanomata, Takuya Moriya, Yuji Kozuka, Mika Watanabe, Hiroshi Sonoo

Pancreatic cancer and depression: myth and truth

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Debate

Martina Mayr, Roland M Schmid

Complete response in gallbladder cancer to erlotinib plus gemcitabine does not require mutation of the epidermal growth factor receptor gene: a case report

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Case report

Kabir Mody, Edward Strauss, Robert Lincer, Richard C Frank

Alternative splicing and nonsense-mediated decay regulate telomerase reverse transcriptase (TERT) expression during virus-induced lymphomagenesis in vivo

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Research article

Souheila Amor, Sylvie Remy, Ginette Dambrine, Yves Le Vern, Denis Rasschaert, Sylvie Laurent

Transperineal prostate brachytherapy, using I-125 seed with or without adjuvant androgen deprivation, in patients with intermediate-risk prostate cancer: study protocol for a phase III, multicenter, randomized, controlled trial

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Study protocol

Kenta Miki, Takayoshi Kiba, Hiroshi Sasaki, Masahito Kido, Manabu Aoki, Hiroyuki Takahashi, Keiko Miyakoda, Takushi Dokiya, Hidetoshi Yamanaka, Masanori Fukushima, Shin Egawa

Comparative survival analysis of breast cancer microarray studies identifies important prognostic genetic pathways

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Research article

Jeffrey C Miecznikowski, Dan Wang, Song Liu, Lara Sucheston, David Gold

Interleukins, laminin and epstein - barr virus latent membrane protein 1 (EBV LMP1) Promote metastatic phenotype in nasopharyngeal carcinoma

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Research article

Michelle MS Chew, Sook-Yee Gan, Alan SB Khoo, Eng-Lai Tan

The PstI/RsaI and DraI polymorphisms of CYP2E1and head and neck cancer risk: a meta-analysis based on 21 case-control studies

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Research article

Kefu Tang, Yang Li, Zhao Zhang, Yunmin Gu, Yuyu Xiong, Guoyin Feng, Lin He, Shengying Qin

Identification of differentially expressed genes using an annealing control primer system in stage III serous ovarian carcinoma

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Research article

Yun-Sook Kim, Jin Hwan Do, Sumi Bae, Dong-Han Bae, Woong Shick Ahn

Epigenetic inactivation of the NORE1gene correlates with malignant progression of colorectal tumors

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Research article

Chang Kyun Lee, Jin-Hee Lee, Min-Goo Lee, Seong-In Jeong, Tae-Kyu Ha, Min-Ju Kang, Byung-Kyu Ryu, Young Hwangbo, Jae-Jun Shim, Jae Young Jang, Kil Yeon Lee, Hyo Jong Kim, Sung-Gil Chi

Chemokine-mediated distribution of dendritic cell subsets in renal cell carcinoma

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Research article

Peter Middel, Sven Brauneck, Werner Meyer, Heinz-Joachim Radzun

Oligodendroglioma of the ciliary body: a unique case report and the review of literature

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Case report

Qing Guo, Jie Hao, Shou bin Sun, Shou ping Xu, Qian Yang, Qi liang Guo, Guo dong Cui

Herbal compound "Songyou Yin" reinforced the ability of interferon-alfa to inhibit the enhanced metastatic potential induced by palliative resection of hepatocellular carcinoma in nude mice

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Research article

Xiu-Yan Huang, Zi-Li Huang, Lu Wang, Yong-Hua Xu, Xin-Yu Huang, Kai-Xing Ai, Qi Zheng, Zhao-You Tang

Comparison of darbepoetin alfa dosed weekly (QW) vs. extended dosing schedule (EDS) in the treatment of anemia in patients receiving multicycle chemotherapy in a randomized, phase 2, open-label trial

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Research article

Lee Schwartzberg, Ronald Burkes, Barry Mirtsching, Timothy Rearden, Peter Silberstein, Lorrin Yee, Amy Inamoto, Tom Lillie

Prognostic factors for outcomes after whole-brain irradiation of brain metastases from relatively radioresistant tumors: a retrospective analysis

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Research article

Thekla Meyners, Christine Heisterkamp, Jan-Dirk Kueter, Theo Veninga, Lukas JA Stalpers, Steven E Schild, Dirk Rades

Retrospective analyses of cisplatin-based doublet combination chemotherapy in patients with advanced gastric cancer

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Research article

Do Hyoung Lim, Se Hoon Park, Keon Woo Park, Jung Hun Kang, Sung Yong Oh, In Gyu Hwang, Jung Mi Kwon, Sang-Cheol Lee, Hui-Young Lee, Hyeong Su Kim, Ho Yeong Lim, Won Ki Kang

NF-κB targeting by way of IKK inhibition sensitizes lung cancer cells to adenovirus delivery of TRAIL

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Research article

Cigdem Aydin, Ahter D Sanlioglu, Atil Bisgin, Burcak Yoldas, Levent Dertsiz, Bahri Karacay, Thomas S Griffith, Salih Sanlioglu

Clinicopathologic characteristics and prognostic factors of ovarian fibrosarcoma: the results of a multi-center retrospective study

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Research article

Long Huang, Ling-Min Liao, Hui-Yun Wang, Min Zheng

Statistical techniques to construct assays for identifying likely responders to a treatment under evaluation from cell line genomic data

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Research article

Erich P Huang, Jane Fridlyand, Nicholas Lewin-Koh, Peng Yue, Xiaoyan Shi, David Dornan, Bart Burington

Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin

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Research article

Manuela Pinheiro, Terje Ahlquist, Stine A Danielsen, Guro E Lind, Isabel Veiga, Carla Pinto, Vera Costa, Luís Afonso, Olga Sousa, Maria Fragoso, Lúcio Santos, Rui Henrique, Paula Lopes, Carlos Lopes, Ragnhild A Lothe, Manuel R Teixeira

Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients

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Research article

Mariya Y Radeva, Franziska Jahns, Anne Wilhelm, Michael Glei, Utz Settmacher, Karl Otto Greulich, Henning Mothes

Modified Gompertz equation for electrotherapy murine tumor growth kinetics: predictions and new hypotheses

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Research article

Luis E Bergues Cabrales, Juan J Godina Nava, Andrés Ramírez Aguilera, Javier A González Joa, Héctor M Camué Ciria, Maraelys Morales González, Miriam Fariñas Salas, Manuel Verdecia Jarque, Tamara Rubio González, Miguel A O'Farril Mateus, Soraida C Acosta Brooks, Fabiola Suárez Palencia, Lisset Ortiz Zamora, María C Céspedes Quevedo, Sarah Edward Seringe, Vladimir Crombet Cuitié, Idelisa Bergues Cabrales, Gustavo Sierra González

Therapy with un-engineered naïve rat umbilical cord matrix stem cells markedly inhibits growth of murine lung adenocarcinoma

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Research article

Dharmendra K Maurya, Chiyo Doi, Atsushi Kawabata, Marla M Pyle, Clay King, Zhihong Wu, Deryl Troyer, Masaaki Tamura

Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions

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Research article

Li Xie, Xi Chen, Lifeng Wang, Xiaoping Qian, Tingting Wang, Jia Wei, Lixia Yu, Yitao Ding, Chenyu Zhang, Baorui Liu

Preferences for active and aggressive intervention among patients with advanced cancer

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Research article

Vincent Maida, Jonathan Peck, Marguerite Ennis, Navjot Brar, Alexandria R Maida

Resveratrol represses YKL-40 expression in human glioma U87 cells

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Research article

Wei Zhang, Koji Murao, Xiang Zhang, Kensuke Matsumoto, Suwarni Diah, Masaki Okada, Keisuke Miyake, Nobuyuki Kawai, Zhou Fei, Takashi Tamiya

Assessment of depression and anxiety in adult cancer outpatients: a cross-sectional study

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Research article

Nauman A Jadoon, Waqar Munir, Mohammad A Shahzad, Zeshan S Choudhry

Gene expression analysis of cell death induction by Taurolidine in different malignant cell lines

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Research article

Ansgar M Chromik, Stephan A Hahn, Adrien Daigeler, Annegret Flier, Daniel Bulut, Christina May, Kamran Harati, Jan Roschinsky, Dominique Sülberg, Dirk Weyhe, Ulrich Mittelkötter, Waldemar Uhl

Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts

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Research article

Johanna Tuomela, Tove J Grönroos, Maija P Valta, Jouko Sandholm, Aleksi Schrey, Jani Seppänen, Päivi Marjamäki, Sarita Forsback, Ilpo Kinnunen, Olof Solin, Heikki Minn, Pirkko L Härkönen

Potential pitfalls in MitoChip detected tumor-specific somatic mutations: a call for caution when interpreting patient data

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Research article

Malliya Gounder Palanichamy, Ya-Ping Zhang

Role of 14-3-3σ in poor prognosis and in radiation and drug resistance of human pancreatic cancers

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Research article

Zhaomin Li, Zizheng Dong, David Myer, Michele Yip-Schneider, Jianguo Liu, Ping Cui, C Max Schmidt, Jian-Ting Zhang

Prioritizing genes associated with prostate cancer development

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Research article

Ivan P Gorlov, Kanishka Sircar, Hongya Zhao, Sankar N Maity, Nora M Navone, Olga Y Gorlova, Patricia Troncoso, Curtis A Pettaway, Jin Young Byun, Christopher J Logothetis

SHOX2 DNA Methylation is a Biomarker for the diagnosis of lung cancer based on bronchial aspirates

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Research article

Bernd Schmidt, Volker Liebenberg, Dimo Dietrich, Thomas Schlegel, Christoph Kneip, Anke Seegebarth, Nadja Flemming, Stefanie Seemann, Jürgen Distler, Jörn Lewin, Reimo Tetzner, Sabine Weickmann, Ulrike Wille, Triantafillos Liloglou, Olaide Raji, Martin Walshaw, Michael Fleischhacker, Christian Witt, John K Field

Up-regulated expression of type II very low density lipoprotein receptor correlates with cancer metastasis and has a potential link to β-catenin in different cancers

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Research article

Lei He, Yanjun Lu, Peng Wang, Jun Zhang, Chuanchang Yin, Shen Qu

Antiproliferative and pro-apoptotic effects afforded by novel Src-kinase inhibitors in human neuroblastoma cells

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Research article

Michele Navarra, Marilena Celano, Jessica Maiuolo, Silvia Schenone, Maurizio Botta, Adriano Angelucci, Placido Bramanti, Diego Russo

The influence of nativity and neighborhoods on breast cancer stage at diagnosis and survival among California Hispanic women

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Research article

Theresa HM Keegan, Thu Quach, Sarah Shema, Sally L Glaser, Scarlett L Gomez

Improved prognostic classification of breast cancer defined by antagonistic activation patterns of immune response pathway modules

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Research article

Andrew E Teschendorff, Sergio Gomez, Alex Arenas, Dorraya El-Ashry, Marcus Schmidt, Mathias Gehrmann, Carlos Caldas

HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression

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Research article

Jacqueline Kessler, Antje Hahnel, Henri Wichmann, Swetlana Rot, Matthias Kappler, Matthias Bache, Dirk Vordermark

Randomised trial of proton vs. carbon ion radiation therapy in patients with low and intermediate grade chondrosarcoma of the skull base, clinical phase III study

Open Access
Study protocol

Anna V Nikoghosyan, Geraldine Rauch, Marc W Münter, Alexandra D Jensen, Stephanie E Combs, Meinhard Kieser, Jürgen Debus

Randomised trial of proton vs. carbon ion radiation therapy in patients with chordoma of the skull base, clinical phase III study HIT-1-Study

Open Access
Study protocol

Anna V Nikoghosyan, Irini Karapanagiotou-Schenkel, Marc W Münter, Alexandra D Jensen, Stephanie E Combs, Jürgen Debus

High number of CD45RO+ tumor infiltrating lymphocytes is an independent prognostic factor in non-metastasized (stage I-IIA) esophageal adenocarcinoma

Open Access
Research article

Sandra Rauser, Rupert Langer, Sebastian Tschernitz, Peter Gais, Uta Jütting, Marcus Feith, Heinz Höfler, Axel Walch

An experimental study on cervix cancer with combination of HSV-TK/GCV suicide gene therapy system and 60Co radiotherapy

Open Access
Research article

Daozhen Chen, Qiusha Tang

Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

Open Access
Research article

Feng-Hou Gao, Xiao-Hui Hu, Wei Li, Hua Liu, Yan-Jie Zhang, Zhu-Ying Guo, Mang-Hua Xu, Shi-Ting Wang, Bin Jiang, Feng Liu, Ying-Zheng Zhao, Yong Fang, Fang-Yuan Chen, Ying-Li Wu

Plexin-B1 silencing inhibits ovarian cancer cell migration and invasion

Open Access
Research article

Shuangmei Ye, Xing Hao, Ting Zhou, Mingfu Wu, Juncheng Wei, Yongjun Wang, Li Zhou, Xuefeng Jiang, Li Ji, Yin Chen, Lanying You, Yiqun Zhang, Gang Xu, Jianfeng Zhou, Ding Ma, Shixuan Wang

CCC meets ICU: Redefining the role of critical care of cancer patients

Open Access
Debate

Michael von Bergwelt-Baildon, Michael J Hallek, Alexander A Shimabukuro-Vornhagen, Matthias Kochanek

Polymorphisms in regulatory regions of Cyclooxygenase-2 gene and breast cancer risk in Brazilians: a case-control study

Open Access
Research article

Diogo N Piranda, Juliana S Festa-Vasconcellos, Laura M Amaral, Anke Bergmann, Rosane Vianna-Jorge

Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma

Open Access
Research article

Mehdi H Shahi, Mohammad Afzal, Subrata Sinha, Charles G Eberhart, Juan A Rey, Xing Fan, Javier S Castresana

Treatment of patients with atypical meningiomas Simpson grade 4 and 5 with a carbon ion boost in combination with postoperative photon radiotherapy: The MARCIE Trial

Open Access
Study protocol

Stephanie E Combs, Lutz Edler, Iris Burkholder, Stefan Rieken, Daniel Habermehl, Oliver Jäkel, Thomas Haberer, Andreas Unterberg, Wolfgang Wick, Jürgen Debus, Renate Haselmann

Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells

Open Access
Research article

Chao-Jie Wang, Johannes Stratmann, Zong-Guang Zhou, Xiao-Feng Sun

TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma

Open Access
Research article

Shumin Wang, Xue Xiao, Xiaoying Zhou, Tingting Huang, Chunping Du, Nana Yu, Yingxi Mo, Longde Lin, Jinyan Zhang, Ning Ma, Mariko Murata, Guangwu Huang, Zhe Zhang

Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles

Open Access
Research article

Robert Klopfleisch, Dido Lenze, Michael Hummel, Achim D Gruber

Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma

Open Access
Research article

Beth A Tamburini, Tzu L Phang, Susan P Fosmire, Milcah C Scott, Susan C Trapp, Megan M Duckett, Sally R Robinson, Jill E Slansky, Leslie C Sharkey, Gary R Cutter, John W Wojcieszyn, Donald Bellgrau, Robert M Gemmill, Lawrence E Hunter, Jaime F Modiano

Eastern asian expert panel opinion: designing clinical trials of molecular targeted therapy for hepatocellular carcinoma

Open Access
Correspondence

Winnie Yeo, Pei-Jer Chen, Junji Furuse, Kwang-Hyub Han, Chiun Hsu, Ho-Yeong Lim, Hanlim Moon, Shukui Qin, Ee-Min Yeoh, Sheng-Long Ye

Topoisomerase II alpha expression and the benefit of adjuvant chemotherapy for postoperative patients with non-small cell lung cancer

Open Access
Research article

Shi Yan, Jiao Shun-Chang, Chen Li, Li Jie, Lv Ya-Li, Wang Ling-Xiong

Population-based study of ovarian cancer in Côte d'Or: prognostic factors and trends in relative survival rates over the last 20 years

Open Access
Research article

Zeinab Hamidou, Sylvain Causeret, Tienhan S Dabakuyo, Julie Gentil, Laurent Arnould, Patrick Roignot, Thierry Altwegg, Marie-Laure Poillot, Franck Bonnetain, Patrick Arveux

Neck dissection and post-operative chemotherapy with dimethyl triazeno imidazole carboxamide and cisplatin protocol are useful for oral mucosal melanoma

Open Access
Research article

Xi Yang, Guo-xin Ren, Chen-ping Zhang, Guo-yu Zhou, Yong-jie Hu, Wen-jun Yang, Wei Guo, Jiang Li, Lai-ping Zhong

Design of the Quality of Life in Motion (QLIM) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of a combined physical exercise and psychosocial training program to improve physical fitness in children with cancer

Open Access
Study protocol

Katja I Braam, Elisabeth M van Dijk, Margreet A Veening, Marc B Bierings, Johannes HM Merks, Martha A Grootenhuis, Mai JM Chinapaw, Gerben Sinnema, Tim Takken, Jaap Huisman, Gertjan JL Kaspers, Eline van Dulmen-den Broeder

Racial differences in treatment and survival in older patients with diffuse large B-cell lymphoma (DLBCL)

Open Access
Research article

Robert Griffiths, Michelle Gleeson, Kevin Knopf, Mark Danese

COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer

Open Access
Research article

Sharon A Glynn, Robyn L Prueitt, Lisa A Ridnour, Brenda J Boersma, Tiffany M Dorsey, David A Wink, Julie E Goodman, Harris G Yfantis, Dong H Lee, Stefan Ambs

Tumour auto-antibody screening: performance of protein microarrays using SEREX derived antigens

Open Access
Research article

René Stempfer, Parvez Syed, Klemens Vierlinger, Rudolf Pichler, Eckart Meese, Petra Leidinger, Nicole Ludwig, Albert Kriegner, Christa Nöhammer, Andreas Weinhäusel

Merging transcriptomics and metabolomics - advances in breast cancer profiling

Open Access
Research article

Eldrid Borgan, Beathe Sitter, Ole Christian Lingjærde, Hilde Johnsen, Steinar Lundgren, Tone F Bathen, Therese Sørlie, Anne-Lise Børresen-Dale, Ingrid S Gribbestad

Steroid receptor coactivator 1 deficiency increases MMTV-neu mediated tumor latency and differentiation specific gene expression, decreases metastasis, and inhibits response to PPAR ligands

Open Access
Research article

Ji Seung Han, David L Crowe

Exclusive and adjuvant radiotherapy in breast cancer patients with synchronous metastases

Open Access
Debate

Romuald Le Scodan, David Ali, Denise Stevens

Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas

Open Access
Research article

Ymera Pignochino, Ivana Sarotto, Caterina Peraldo-Neia, Junia Y Penachioni, Giuliana Cavalloni, Giorgia Migliardi, Laura Casorzo, Giovanna Chiorino, Mauro Risio, Alberto Bardelli, Massimo Aglietta, Francesco Leone

p21WAF1/CIP1 gene transcriptional activation exerts cell growth inhibition and enhances chemosensitivity to cisplatin in lung carcinoma cell

Open Access
Research article

Junxia Wei, Jiang Zhao, Min Long, Yuan Han, Xi Wang, Fang Lin, Jihong Ren, Ting He, Huizhong Zhang

A randomized phase III study of the docetaxel/carboplatin combination versus docetaxel single-agent as second line treatment for patients with advanced/metastatic Non-Small Cell Lung Cancer

Open Access
Research article

Athanasios G Pallis, Sophia Agelaki, Athina Agelidou, Ioannis Varthalitis, Kostas Syrigos, Nikolaos Kentepozidis, Georgia Pavlakou, Athanasios Kotsakis, Emmanouel Kontopodis, Vassilis Georgoulias

Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen

Open Access
Research article

Velasco Cimica, Melissa E Smith, Zhikai Zhang, Deepti Mathur, Sridhar Mani, Ganjam V Kalpana

A panel of kallikrein markers can predict outcome of prostate biopsy following clinical work-up: an independent validation study from the European Randomized Study of Prostate Cancer screening, France

Open Access
Research article

Amine Benchikh, Caroline Savage, Angel Cronin, Gilles Salama, Arnauld Villers, Hans Lilja, Andrew Vickers

Polymorphisms in genes involved in the estrogen pathway and mammographic density

Open Access
Research article

Isabelle Dumas, Caroline Diorio

Should helical tomotherapy replace brachytherapy for cervical cancer? Case report

Open Access
Case report

Chen-Hsi Hsieh, Ming-Chow Wei, Yao-Peng Hsu, Ngot-Swan Chong, Yu-Jen Chen, Sheng-Mou Hsiao, Yen-Ping Hsieh, Li-Ying Wang, Pei-Wei Shueng

Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells

Open Access
Research article

Michela Carlet, Kristina Janjetovic, Johannes Rainer, Stefan Schmidt, Renate Panzer-Grümayer, Georg Mann, Martina Prelog, Bernhard Meister, Christian Ploner, Reinhard Kofler

Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer

Open Access
Research article

Elton Rexhepaj, Karin Jirstrom, Darran P O'Connor, Sallyann L O'Brien, Goran Landberg, Michael J Duffy, Donal J Brennan, William M Gallagher

Evaluation of FTIR Spectroscopy as a diagnostic tool for lung cancer using sputum

Open Access
Research article

Paul D Lewis, Keir E Lewis, Robin Ghosal, Sion Bayliss, Amanda J Lloyd, John Wills, Ruth Godfrey, Philip Kloer, Luis AJ Mur

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis

Open Access
Research article

Dusan Djokovic, Alexandre Trindade, Joana Gigante, Marina Badenes, Lilliana Silva, Ren Liu, Xiuqing Li, Ming Gong, Valery Krasnoperov, Parkash S Gill, Antonio Duarte

The use of chemotherapy regimens carrying a moderate or high risk of febrile neutropenia and the corresponding management of febrile neutropenia: an expert survey in breast cancer and non-Hodgkin's lymphoma

Open Access
Research article

Laetitia Gerlier, Mark Lamotte, Ahmad Awada, André Bosly, Greet Bries, Véronique Cocquyt, Christian Focan, Stéphanie Henry, Yassine Lalami, Jean-Pascal Machiels, Jeroen Mebis, Nicole Straetmans, Didier Verhoeven, Luc Somers

Characteristic odour in the blood reveals ovarian carcinoma

Open Access
Research article

György Horvath, Håkan Andersson, Gunnar Paulsson

If it is in the marrow, is it also in the blood? An analysis of 1,000 paired samples from patients with B-cell non-Hodgkin lymphoma

Open Access
Research article

Patrizia Mancuso, Angelica Calleri, Pierluigi Antoniotti, Jessica Quarna, Giancarlo Pruneri, Francesco Bertolini

Low-grade extraskeletal osteosarcoma of the chest wall: case report and review of literature

Open Access
Case report

Renaud Sabatier, Corinne Bouvier, Gonzague de Pinieux, Anthony Sarran, Isabelle Brenot-Rossi, Florence Pedeutour, Bruno Chetaille, Patrice Viens, Pierre-Jean Weiller, François Bertucci

Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts

Open Access
Research article

Anne Sofie Brems-Eskildsen, Karsten Zieger, Helle Toldbod, Cherie Holcomb, Russell Higuchi, Francisco Mansilla, Pia P Munksgaard, Michael Borre, Torben F Ørntoft, Lars Dyrskjøt

Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells

Open Access
Research article

Hari Raghu, Prasanna Kumar Sodadasu, Rama Rao Malla, Christopher S Gondi, Norman Estes, Jasti S Rao

Weight change during chemotherapy changes the prognosis in non metastatic breast cancer for the worse

Open Access
Research article

Emilie Thivat, Sophie Thérondel, Olivier Lapirot, Catherine Abrial, Pierre Gimbergues, Emilie Gadéa, Eloïse Planchat, Fabrice Kwiatkowski, Marie A Mouret-Reynier, Philippe Chollet, Xavier Durando

Mutually exclusive expression of DLX2 and DLX5/6 is associated with the metastatic potential of the human breast cancer cell line MDA-MB-231

Open Access
Research article

Monica Morini, Simonetta Astigiano, Yorick Gitton, Laura Emionite, Valentina Mirisola, Giovanni Levi, Ottavia Barbieri

Comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study

Open Access
Research article

Donghong Zhang, Qingying Zhang, Li Zhou, Leijun Huo, Yi Zhang, Zhongying Shen, Yi Zhu

Treatment of locally advanced carcinomas of head and neck with intensity-modulated radiation therapy (IMRT) in combination with cetuximab and chemotherapy: the REACH protocol

Open Access
Study protocol

Gregor Habl, Alexandra D Jensen, Karin Potthoff, Matthias Uhl, Holger Hof, Jacek Hajda, Christian Simon, Jürgen Debus, Robert Krempien, Marc W Münter

Phosphorylated Smad2 in Advanced Stage Gastric Carcinoma

Open Access
Research article

Osamu Shinto, Masakazu Yashiro, Takahiro Toyokawa, Takafumi Nishii, Ryoji Kaizaki, Taro Matsuzaki, Satoru Noda, Naoshi Kubo, Hiroaki Tanaka, Yosuke Doi, Masaichi Ohira, Kazuya Muguruma, Tetsuji Sawada, Kosei Hirakawa

Long-term survival of women with basal-like ductal carcinoma in situ of the breast: a population-based cohort study

Open Access
Research article

Wenjing Zhou, Karin Jirström, Christine Johansson, Rose-Marie Amini, Carl Blomqvist, Olorunsola Agbaje, Fredrik Wärnberg

BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

Open Access
Research article

Henne Holstege, Hugo M Horlings, Arno Velds, Anita Langerød, Anne-Lise Børresen-Dale, Marc J van de Vijver, Petra M Nederlof, Jos Jonkers

14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in Head and Neck cancer cells

Open Access
Research article

Muzafar A Macha, Ajay Matta, SS Chauhan, KW Michael Siu, Ranju Ralhan

Recurrence and mortality according to Estrogen Receptor status for breast cancer patients undergoing conservative surgery. Ipsilateral breast tumour recurrence dynamics provides clues for tumour biology within the residual breast

Open Access
Research article

Romano Demicheli, Ilaria Ardoino, Patrizia Boracchi, Danila Coradini, Roberto Agresti, Cristina Ferraris, Massimiliano Gennaro, William JM Hrushesky, Elia Biganzoli

Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene

Open Access
Research article

Francesca Pellicano, Rachel E Thomson, Gareth J Inman, Tomoko Iwata

Design of the Resistance and Endurance exercise After ChemoTherapy (REACT) study: A randomized controlled trial to evaluate the effectiveness and cost-effectiveness of exercise interventions after chemotherapy on physical fitness and fatigue

Open Access
Study protocol

Caroline S Kampshoff, Laurien M Buffart, Goof Schep, Willem van Mechelen, Johannes Brug, Mai JM Chinapaw

Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-β phosphorylation, and microvessel density in gastric cancer

Open Access
Research article

Shioto Suzuki, Yoh Dobashi, Yayoi Hatakeyama, Ryosuke Tajiri, Takashi Fujimura, Carl H Heldin, Akishi Ooi

KRAS analysis in colorectal carcinoma: Analytical aspects of Pyrosequencing and allele-specific PCR in clinical practice

Open Access
Research article

Magnus Sundström, Karolina Edlund, Monica Lindell, Bengt Glimelius, Helgi Birgisson, Patrick Micke, Johan Botling

Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax

Open Access
Research article

Peng Wang, Haining Zhen, Xinbiao Jiang, Wei Zhang, Xin Cheng, Geng Guo, Xinggang Mao, Xiang Zhang

Specific genomic aberrations in primary colorectal cancer are associated with liver metastases

Open Access
Research article

Sjoerd C Bruin, Christiaan Klijn, Gerrit-Jan Liefers, Linde M Braaf, Simon A Joosse, Eric H van Beers, Victor J Verwaal, Hans Morreau, Lodewyk F Wessels, Marie-Louise F van Velthuysen, Rob AEM Tollenaar, Laura J van't Veer

The Brustkrebs-Studien.de website for breast cancer patients: User acceptance of a German internet portal offering information on the disease and treatment options, and a clinical trials matching service

Open Access
Research article

Markus Wallwiener, Christian W Wallwiener, Sara Y Brucker, Andreas D Hartkopf, Tanja N Fehm, Julia K Kansy

The invasive lobular carcinoma as a prototype luminal A breast cancer: A retrospective cohort study

Open Access
Research article

So-Youn Jung, Junsoo Jeong, Seung-Ho Shin, Youngmee Kwon, Eun-A Kim, Kyoung Lan Ko, Kyung Hwan Shin, Keun Seok Lee, In Hae Park, Seeyoun Lee, Seok Won Kim, Han-Sung Kang, Jungsil Ro

Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis

Open Access
Research article

Salomé González-Reyes, Laura Marín, Lucía González, Luis O González, José M del Casar, Maria L Lamelas, José M González-Quintana, Francisco J Vizoso

Assessment of a six gene panel for the molecular detection of circulating tumor cells in the blood of female cancer patients

Open Access
Research article

Eva Obermayr, Fatima Sanchez-Cabo, Muy-Kheng M Tea, Christian F Singer, Michael Krainer, Michael B Fischer, Jalid Sehouli, Alexander Reinthaller, Reinhard Horvat, Georg Heinze, Dan Tong, Robert Zeillinger

Impact of maximum Standardized Uptake Value (SUVmax) evaluated by 18-Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG-PET/CT) on survival for patients with advanced renal cell carcinoma: a preliminary report

Open Access
Research article

Kazuhiro Namura, Ryogo Minamimoto, Masahiro Yao, Kazuhide Makiyama, Takayuki Murakami, Futoshi Sano, Narihiko Hayashi, Ukihide Tateishi, Hanako Ishigaki, Takeshi Kishida, Takeshi Miura, Kazuki Kobayashi, Sumio Noguchi, Tomio Inoue, Yoshinobu Kubota, Noboru Nakaigawa

Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition

Open Access
Research article

Christina Hackl, Sven A Lang, Christian Moser, Akira Mori, Stefan Fichtner-Feigl, Claus Hellerbrand, Wolfgang Dietmeier, Hans J Schlitt, Edward K Geissler, Oliver Stoeltzing

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer

Open Access
Research article

Kathy Vanderlaag, Yunpeng Su, Arthur E Frankel, Robert C Burghardt, Rola Barhoumi, Gayathri Chadalapaka, Indira Jutooru, Stephen Safe

Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis

Open Access
Research article

Carolyn M Hutter, Martha L Slattery, David J Duggan, Jill Muehling, Karen Curtin, Li Hsu, Shirley AA Beresford, Aleksandar Rajkovic, Gloria E Sarto, James R Marshall, Nazik Hammad, Robert Wallace, Karen W Makar, Ross L Prentice, Bette J Caan, John D Potter, Ulrike Peters

Design of the EXercise Intervention after Stem cell Transplantation (EXIST) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of an individualized high intensity physical exercise program on fitness and fatigue in patients with multiple myeloma or (non-) Hodgkin's lymphoma treated with high dose chemotherapy and autologous stem cell transplantation

Open Access
Study protocol

Saskia Persoon, Marie José Kersten, Mai JM ChinAPaw, Laurien M Buffart, Heleen Burghout, Goof Schep, Johannes Brug, Frans Nollet

Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progressioan

Open Access
Research article

Mikhail G Dozmorov, Joseph T Azzarello, Jonathan D Wren, Kar-Ming Fung, Qing Yang, Jeffrey S Davis, Robert E Hurst, Daniel J Culkin, Trevor M Penning, Hsueh-Kung Lin

Design of the Physical exercise during Adjuvant Chemotherapy Effectiveness Study (PACES):A randomized controlled trial to evaluate effectiveness and cost-effectiveness of physical exercise in improving physical fitness and reducing fatigue

Open Access
Study protocol

Hanna van Waart, Martijn M Stuiver, Wim H van Harten, Gabe S Sonke, Neil K Aaronson

Ethnic and socioeconomic trends in breast cancer incidence in New Zealand

Open Access
Research article

Ruth Cunningham, Caroline Shaw, Tony Blakely, June Atkinson, Diana Sarfati

Impact of hormonal treatment duration in combination with radiotherapy for locally advanced prostate cancer: Meta-analysis of randomized trials

Open Access
Research article

Federica Cuppone, Emilio Bria, Diana Giannarelli, Vanja Vaccaro, Michele Milella, Cecilia Nisticò, Enzo Maria Ruggeri, Isabella Sperduti, Sergio Bracarda, Paola Pinnarò, Gaetano Lanzetta, Paola Muti, Francesco Cognetti, Paolo Carlini

Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures

Open Access
Research article

Joseph R Cohen, Daniel Z Resnick, Pawel Niewiadomski, Hongmei Dong, Linda M Liau, James A Waschek

Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase

Open Access
Research article

Uffe H Olesen, Jakob G Petersen, Antje Garten, Wieland Kiess, Jun Yoshino, Shin-Ichiro Imai, Mette K Christensen, Peter Fristrup, Annemette V Thougaard, Fredrik Björkling, Peter B Jensen, Søren J Nielsen, Maxwell Sehested

Characterization of ductal and lobular breast carcinomas using novel prolactin receptor isoform specific antibodies

Open Access
Research article

Erika Ginsburg, Stefanie Alexander, Sarah Lieber, Sarah Tarplin, Luwanda Jenkins, Linda Pang, Christopher D Heger, Paul Goldsmith, Barbara K Vonderhaar

Potential drug interactions and duplicate prescriptions among ambulatory cancer patients: a prevalence study using an advanced screening method

Open Access
Study protocol

Roelof WF van Leeuwen, Eleonora L Swart, Frits A Boom, Martin S Schuitenmaker, Jacqueline G Hugtenburg

Differential expression of anterior gradient gene AGR2 in prostate cancer

Open Access
Research article

Erin L Maresh, Vei Mah, Mohammad Alavi, Steve Horvath, Lora Bagryanova, Emily S Liebeskind, Laura A Knutzen, Yong Zhou, David Chia, Alvin Y Liu, Lee Goodglick

Initial partial response and stable disease according to RECIST indicate similar survival for chemotherapeutical patients with advanced non-small cell lung cancer

Open Access
Research article

Lijie He, Yuee Teng, Bo Jin, Mingfang Zhao, Ping Yu, Xuejun Hu, Jingdong Zhang, Songbai Li, Yaling Gao, Yunpeng Liu

Gene expression of PMP22 is an independent prognostic factor for disease-free and overall survival in breast cancer patients

Open Access
Research article

Dan Tong, Georg Heinze, Dietmar Pils, Andrea Wolf, Christian F Singer, Nicole Concin, Gerda Hofstetter, Ingrid Schiebel, Margaretha Rudas, Robert Zeillinger

VEGFR2 heterogeneity and response to anti-angiogenic low dose metronomic cyclophosphamide treatment

Open Access
Research article

Steven G Patten, Una Adamcic, Kristen Lacombe, Kanwal Minhas, Karolina Skowronski, Brenda L Coomber

Induction of cell cycle arrest at G1 and S phases and cAMP-dependent differentiation in C6 glioma by low concentration of cycloheximide

Open Access
Research article

Xijun Liu, Jin-Ming Yang, Samuel S Zhang, Xin-Yuan Liu, David X Liu

Malignant transformation of oral leukoplakia: a retrospective cohort study of 218 Chinese patients

Open Access
Research article

Wei Liu, Yu-Feng Wang, Hai-Wei Zhou, Peng Shi, Zeng-Tong Zhou, Guo-Yao Tang

Expression of BMI-1 and Mel-18 in breast tissue - a diagnostic marker in patients with breast cancer

Open Access
Research article

Margit LH Riis, Torben Lüders, Anne-Jorunn Nesbakken, Hilde S Vollan, Vessela Kristensen, Ida RK Bukholm

The Colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information

Open Access
Research article

Wendy L Allen, Puthen V Jithesh, Gavin R Oliver, Irina Proutski, Daniel B Longley, Heinz-Josef Lenz, Vitali Proutski, Paul Harkin, Patrick G Johnston

Tumor location and patient characteristics of colon and rectal adenocarcinomas in relation to survival and TNM classes

Open Access
Research article

Kari Hemminki, Irene Santi, Marianne Weires, Hauke Thomsen, Jan Sundquist, Justo Lorenzo Bermejo

Evaluation of Best Supportive Care and Systemic Chemotherapy as Treatment Stratified according to the retrospective Peritoneal Surface Disease Severity Score (PSDSS) for Peritoneal Carcinomatosis of Colorectal Origin

Open Access
Research article

Joerg OW Pelz, Terence C Chua, Jesus Esquivel, Alexander Stojadinovic, Joerg Doerfer, David L Morris, Uwe Maeder, Christoph-Thomas Germer, Alexander G Kerscher

Possibility of multivariate function composed of plasma amino acid profiles as a novel screening index for non-small cell lung cancer: a case control study

Open Access
Research article

Jun Maeda, Masahiko Higashiyama, Akira Imaizumi, Tomio Nakayama, Hiroshi Yamamoto, Takashi Daimon, Minoru Yamakado, Fumio Imamura, Ken Kodama

Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX®Colon Cancer Assay

Open Access
Technical advance

Kim M Clark-Langone, Chithra Sangli, Jayadevi Krishnakumar, Drew Watson

Preoperative dexamethasone reduces postoperative pain, nausea and vomiting following mastectomy for breast cancer

Open Access
Research article

Jorge Gómez-Hernández, Alba Lorena Orozco-Alatorre, Marisela Domínguez-Contreras, Antonio Oceguera-Villanueva, Salvador Gómez-Romo, Andrea Socorro Alvarez Villaseñor, Clotilde Fuentes-Orozco, Alejandro González-Ojeda

Meta-analysis of quantitative diffusion-weighted MR imaging in the differential diagnosis of breast lesions

Open Access
Research article

Xin Chen, Wen-ling Li, Yi-li Zhang, Qian Wu, You-min Guo, Zhi-lan Bai

iASPP is over-expressed in human non-small cell lung cancer and regulates the proliferation of lung cancer cells through a p53 associated pathway

Open Access
Research article

Jinfeng Chen, Fei Xie, Lijian Zhang, Wen G Jiang

Circulating endothelial cells are an early predictor in renal cell carcinoma for tumor response to sunitinib

Open Access
Research article

Viktor Gruenwald, Gernot Beutel, Susanne Schuch-Jantsch, Christoph Reuter, Philipp Ivanyi, Arnold Ganser, Marion Haubitz

Toxic risk of stereotactic body radiotherapy and concurrent helical tomotherapy followed by erlotinib for non-small-cell lung cancer treatment - case report

Open Access
Case report

Chen-Hsi Hsieh, Hou-Tai Chang, Shih-Chiang Lin, Yu-Jen Chen, Li-Ying Wang, Yen-Ping Hsieh, Chien-An Chen, Ngot-Swan Chong, Shoei Long Lin, Chun-Yi Chen, Pei-Wei Shueng

Separate and combined analysis of successive dependent outcomes after breast-conservation surgery: recurrence, metastases, second cancer and death

Open Access
Research article

Virginie Rondeau, Simone Mathoulin-Pélissier, Lucie Tanneau, Annie J Sasco, Gaétan MacGrogan, Marc Debled

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In vitro Fertilisation
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Eine australische Studie hat die Krebsinzidenz bei Frauen nach medizinisch assistierter Reproduktion (MAR) untersucht. Insgesamt entspricht das Risiko dem der Allgemeinbevölkerung, einzelne Tumorarten treten jedoch häufiger oder seltener auf.

Wünsche älterer Krebskranker finden offenbar wenig Gehör

13.03.2026
Geriatrische Onkologie
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In einer US-Studie mit unheilbaren Krebspatientinnen und -patienten gaben die meisten einer bestmöglichen Lebensqualität den Vorzug vor längerem Überleben. Auf diesen Wunsch wurde in der Praxis jedoch nicht erkennbar eingegangen.

Dosierung von Irinotecan vom Metabolismus abhängig machen

13.03.2026
Zytostatische Therapie
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Krebskranke, die Irinotecan schlecht verstoffwechseln, haben ein erhöhtes Risiko für schwere toxische Nebenwirkungen. Eine reduzierte Dosis kann davor schützen. Ob dies die Überlebenschancen beeinträchtigt, haben niederländische Medizinerinnen und Mediziner überprüft.

Prostatakarzinom: Frühe Taxantherapie bei Rauchern von Vorteil?

12.03.2026
Prostatakarzinom
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Eine Studie aus Japan legt nahe, dass Raucher mit Prostatakarzinom möglicherweise von einer frühzeitigen Chemotherapie mit Taxanen profitieren.

Update Onkologie

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Hormonelle Behandlung zur ovariellen Stimulation/© Suzi Media / stock.adobe.com (Symbolbild mit Fotomodell), Ältere Frau mit Tabletten in der Hand/© LIGHTFIELD STUDIOS / stock.adobe.com (Symbolbild mit Fotomodell), Infusion/© georgeoprea9 / Getty Images / iStock, Mann raucht eine Zigarette/© (M) StockPlanets / Getty images / istock (Symbolbild mit Fotomodell)

Springer Medizin

BMC Cancer

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