BMC Cancer

Inhalt (529 Artikel)

Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer

Open Access
Research article

Caterina Peraldo-Neia, Giorgia Migliardi, Maurizia Mello-Grand, Filippo Montemurro, Raffaella Segir, Ymera Pignochino, Giuliana Cavalloni, Bruno Torchio, Luciano Mosso, Giovanna Chiorino, Massimo Aglietta

Effects of EpCAM overexpression on human breast cancer cell lines

Open Access
Research article

Johanna M Gostner, Dominic Fong, Oliver A Wrulich, Florian Lehne, Marion Zitt, Martin Hermann, Sylvia Krobitsch, Agnieszka Martowicz, Guenther Gastl, Gilbert Spizzo

A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer

Open Access
Research article

Gayle Bennett, Denise Sadlier, Peter P Doran, Padraic MacMathuna, David W Murray

Synergistic antitumor effect of AAV-mediated TRAIL expression combined with cisplatin on head and neck squamous cell carcinoma

Open Access
Research article

Minghong Jiang, Zheng Liu, Yang Xiang, Hong Ma, Shilian Liu, Yanxin Liu, Dexian Zheng

Establishing a relationship between prolactin and altered fatty acid β-Oxidation via carnitine palmitoyl transferase 1 in breast cancer cells

Open Access
Research article

Katja Linher-Melville, Stephanie Zantinge, Toran Sanli, Hertzel Gerstein, Theodoros Tsakiridis, Gurmit Singh

MicroRNA-203 inhibits cell proliferation by repressing ΔNp63 expression in human esophageal squamous cell carcinoma

Open Access
Research article

Yang Yuan, Zhi-Yong Zeng, Xiao-Hong Liu, De-Jun Gong, Jing Tao, He-Zhong Cheng, Sheng-Dong Huang

SFRP1 reduction results in an increased sensitivity to TGF-β signaling

Open Access
Research article

Kelly J Gauger, Kerry L Chenausky, Molly E Murray, Sallie S Schneider

Challenges associated with the targeted delivery of gelonin to claudin-expressing cancer cells with the use of activatable cell penetrating peptides to enhance potency

Open Access
Research article

Xiaoqin Yuan, Xinjian Lin, Gerald Manorek, Stephen B Howell

In vivo Identification and Specificity assessment of mRNA markers of hypoxia in human and mouse tumors

Open Access
Research article

Morten Busk, Kasper Toustrup, Brita S Sørensen, Jan Alsner, Michael R Horsman, Steen Jakobsen, Jens Overgaard

Circulating lymphocyte is an important determinant of the effectiveness of preoperative radiotherapy in advanced rectal cancer

Open Access
Research article

Joji Kitayama, Koji Yasuda, Kazushige Kawai, Eiji Sunami, Hirokazu Nagawa

Viral-mediated oncolysis is the most critical factor in the late-phase of the tumor regression process upon vaccinia virus infection

Open Access
Research article

Stephanie Weibel, Viktoria Raab, Yong A Yu, Andrea Worschech, Ena Wang, Francesco M Marincola, Aladar A Szalay

Combined treatment of adenoid cystic carcinoma with cetuximab and IMRT plus C12 heavy ion boost: ACCEPT [ACC, Erbitux®and particle therapy]

Open Access
Study protocol

Alexandra D Jensen, Anna Nikoghosyan, Axel Hinke, Jürgen Debus, Marc W Münter

Modulation of TRAIL resistance in colon carcinoma cells: Different contributions of DR4 and DR5

Open Access
Research article

Caroline MM van Geelen, Bodvael Pennarun, Phuong TK Le, Elisabeth GE de Vries, Steven de Jong

Phase II study evaluating consolidation whole abdominal intensity-modulated radiotherapy (IMRT) in patients with advanced ovarian cancer stage FIGO III - The OVAR-IMRT-02 Study

Open Access
Study protocol

Nathalie Rochet, Meinhard Kieser, Florian Sterzing, Sonja Krause, Katja Lindel, Wolfgang Harms, Michael H Eichbaum, Andreas Schneeweiss, Christof Sohn, Juergen Debus

A randomised controlled trial of a cognitive behavioural intervention for women who have menopausal symptoms following breast cancer treatment (MENOS 1): Trial protocol

Open Access
Study protocol

Eleanor Mann, Melanie Smith, Jennifer Hellier, Myra S Hunter

Perioperative cancer cell dissemination detected with a real-time RT-PCR assay for EpCAM is not associated with worse prognosis in pancreatic ductal adenocarcinoma

Open Access
Research article

Gregory Sergeant, Tania Roskams, Jos van Pelt, François Houtmeyers, Raymond Aerts, Baki Topal

A randomised trial of a psychosocial intervention for cancer patients integrated into routine care: the PROMPT study (promoting optimal outcomes in mood through tailored psychosocial therapies)

Open Access
Study protocol

Jane Turner, Brian Kelly, David Clarke, Patsy Yates, Sanchia Aranda, Damien Jolley, Suzanne Chambers, Maryanne Hargraves, Lisa McFadyen

Concurrent cisplatin, continuous infusion fluorouracil and radiotherapy followed by tailored consolidation treatment in non metastatic anal squamous cell carcinoma

Open Access
Research article

Maria G Zampino, Elena Magni, Maria C Leonardi, Luigi Santoro, Elena Petazzi, Cristiana Fodor, Giuseppe Petralia, Cristina Trovato, Franco Nolè, Roberto Orecchia

Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells

Open Access
Research article

Chien-Chih Lee, Yi-Hsiung Lin, Wen-Hsin Chang, Pei-Chin Lin, Yang-Chang Wu, Jan-Gowth Chang

Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma

Open Access
Research article

Vikram Deshpande, Afamefuna Nduaguba, Stephanie M Zimmerman, Sarah M Kehoe, Laura E MacConaill, Gregory Y Lauwers, Cristina Ferrone, Nabeel Bardeesy, Andrew X Zhu, Aram F Hezel

Multimodal microscopy for automated histologic analysis of prostate cancer

Open Access
Research article

Jin Tae Kwak, Stephen M Hewitt, Saurabh Sinha, Rohit Bhargava

The level of claudin-7 is reduced as an early event in colorectal carcinogenesis

Open Access
Research article

Jette Bornholdt, Stine Friis, Sine Godiksen, Steen S Poulsen, Eric Santoni-Rugiu, Hanne C Bisgaard, Inger MB Lothe, Tone Ikdahl, Kjell M Tveit, Egil Johnson, Elin H Kure, Lotte K Vogel

Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma

Open Access
Research article

Helena Carén, Anna Djos, Maria Nethander, Rose-Marie Sjöberg, Per Kogner, Camilla Enström, Staffan Nilsson, Tommy Martinsson

Phase i study evaluating the treatment of patients with hepatocellular carcinoma (HCC) with carbon ion radiotherapy: The PROMETHEUS-01 trial

Open Access
Study protocol

Stephanie E Combs, Daniel Habermehl, Tom Ganten, Jan Schmidt, Lutz Edler, Iris Burkholder, Oliver Jäkel, Thomas Haberer, Jürgen Debus

Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice

Open Access
Research article

Alejandra Ward, Alan Morettin, David Shum, John W Hudson

Transcription factors zeb1, twist and snai1 in breast carcinoma

Open Access
Research article

Ylermi Soini, Hanna Tuhkanen, Reijo Sironen, Ismo Virtanen, Vesa Kataja, Päivi Auvinen, Arto Mannermaa, Veli-Matti Kosma

Leiomyosarcoma with partial rhabdomyoblastic differentiation: First case report of primary cardiac origin

Open Access
Case report

Yoichiro Okubo, Kazutoshi Shibuya, Atsushi Namiki, Kazuhisa Takamura, Noriaki Kameda, Tetsuo Nemoto, Aki Mitsuda, Megumi Wakayama, Minoru Shinozaki, Nobuyuki Hiruta, Kanako Kitahara, Takao Ishiwatari, Junichi Yamazaki

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation

Open Access
Research article

Jane M Valentine, Sonia Kumar, Abdeladim Moumen

FGFR4 Gly388Arg polymorphism contributes to prostate cancer development and progression: A meta-analysis of 2618 cases and 2305 controls

Open Access
Research article

Bin Xu, Na Tong, Shu Q Chen, Li X Hua, Zeng J Wang, Zheng D Zhang, Ming Chen

Treatment of limited stage follicular lymphoma with Rituximab immunotherapy and involved field radiotherapy in a prospective multicenter Phase II trial-MIR trial

Open Access
Study protocol

Mathias Witzens-Harig, Manfred Hensel, Michael Unterhalt, Klaus Herfarth

Downregulation of TGF-beta receptor types II and III in oral squamous cell carcinoma and oral carcinoma-associated fibroblasts

Open Access
Research article

Wenxia Meng, Qingjie Xia, Lanyan Wu, Sixiu Chen, Xin He, Lin Zhang, Qinghong Gao, Hongmei Zhou

Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese: A study of 522 consecutive cases

Open Access
Research article

Zhihong Chi, Siming Li, Xinan Sheng, Lu Si, Chuanliang Cui, Mei Han, Jun Guo

Endosialin expression in relation to clinicopathological and biological variables in rectal cancers with a Swedish clinical trial of preoperative radiotherapy

Open Access
Research article

Zhi-Yong Zhang, Hong Zhang, Gunnar Adell, Xiao-Feng Sun

Subsequent chemotherapy reverses acquired tyrosine kinase inhibitor resistance and restores response to tyrosine kinase inhibitor in advanced non-small-cell lung cancer

Open Access
Case report

Renhua Guo, Xiaofen Chen, Tongshan Wang, Zhiyuan Zhang, Jin Sun, Yongqian Shu

Exploring the uncertainties of early detection results: model-based interpretation of mayo lung project

Open Access
Research article

Lu Shi, Haijun Tian, William J McCarthy, Barbara Berman, Shinyi Wu, Rob Boer

Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer

Open Access
Research article

Genni M Newnham, Matthew Conron, SueAnne McLachlan, Alexander Dobrovic, Hongdo Do, Jason Li, Kenneth Opeskin, Natalie Thompson, Gavin M Wright, David M Thomas

The effect of tobacco, XPC, ERCC2 and ERCC5 genetic variants in bladder cancer development

Open Access
Research article

Kamel Rouissi, Islem Ben Bahria, Karim Bougatef, Raja Marrakchi, Nejla Stambouli, Khouloud Hamdi, Mohamed Cherif, Mohamed Riadh Ben Slama, Mohamed Sfaxi, Fethi Ben Othman, Mohamed Chebil, Amel Benammar Elgaaied, Slah Ouerhani

The role of Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) for qualitative diagnosis of mediastinal and hilar lymphadenopathy: a prospective analysis

Open Access
Research article

Ting Ye, Hong Hu, Xiaoyang Luo, Haiquan Chen

A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population

Open Access
Research article

Keke Zhou, Dezhi Hu, Juan Lu, Weiwei Fan, Hongliang Liu, Hongyan Chen, Gong Chen, Qingyi Wei, Guhong Du, Ying Mao, Daru Lu, Liangfu Zhou

Prognostic impact of CD168 expression in gastric cancer

Open Access
Research article

Sumiya Ishigami, Shinichi Ueno, Yuka Nishizono, Masataka Matsumoto, Hiroshi Kurahara, Takaaki Arigami, Yasuto Uchikado, Tetsuro Setoyama, Hideo Arima, Kita Yoshiaki, Yuko Kijima, Masaki Kitazono, Shoji Natsugoe

EGFR related mutational status and association to clinical outcome of third-line cetuximab-irinotecan in metastatic colorectal cancer

Open Access
Research article

Karen-Lise G Spindler, Niels Pallisgaard, Jan Lindebjerg, Sanne K Frifeldt, Anders Jakobsen

Interaction and uptake of exosomes by ovarian cancer cells

Open Access
Research article

Cristina Escrevente, Sascha Keller, Peter Altevogt, Júlia Costa

Replicase-based plasmid DNA shows anti-tumor activity

Open Access
Research article

B Leticia Rodriguez, Zhen Yu, Woon-Gye Chung, Richard Weiss, Zhengrong Cui

The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines

Open Access
Research article

Stacey L Fossey, Misty D Bear, Jiayuh Lin, Chenglong Li, Eric B Schwartz, Pui-Kai Li, James R Fuchs, Joelle Fenger, William C Kisseberth, Cheryl A London

The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro

Open Access
Research article

Philipp Lechler, Tobias Renkawitz, Valentina Campean, Sanjeevi Balakrishnan, Markus Tingart, Joachim Grifka, Jens Schaumburger

Safety and treatment patterns of multikinase inhibitors in patients with metastatic renal cell carcinoma at a tertiary oncology center in Italy

Open Access
Research article

Camillo Porta, Chiara Paglino, Ilaria Imarisio, Cinzia Canipari, Kristina Chen, Maureen Neary, Mei Sheng Duh

P27Kip1, regulated by glycogen synthase kinase-3β, results in HMBA-induced differentiation of human gastric cancer cells

Open Access
Research article

Min Wei, Zhiwei Wang, Hongliang Yao, Zhongyin Yang, Qing Zhang, Bingya Liu, Yingyan Yu, Liping Su, Zhenggang Zhu, Qinlong Gu

Seminal vesicle metastasis after partial hepatectomy for hepatocellular carcinoma

Open Access
Case report

Li Gong, Minwen Zheng, Yanhong Li, Wendong Zhang, Wangjun Bu, Lifang Shi, Wei Zhang, Hong Yan

Up-regulation of METCAM/MUC18 promotes motility, invasion, and tumorigenesis of human breast cancer cells

Open Access
Research article

Guo-fang Zeng, Shao-xi Cai, Guang-Jer Wu

Prediction of outcome after diagnosis of metachronous contralateral breast cancer

Open Access
Research article

Sara Alkner, Pär-Ola Bendahl, Mårten Fernö, Jonas Manjer, Lisa Rydén

Adjuvant therapy for locally advanced renal cell cancer: A systematic review with meta-analysis

Open Access
Research article

Adolfo JO Scherr, Joao Paulo SN Lima, Emma C Sasse, Carmen SP Lima, André D Sasse

Small lytic peptides escape the inhibitory effect of heparan sulfate on the surface of cancer cells

Open Access
Research article

Bodil Fadnes, Lars Uhlin-Hansen, Inger Lindin, Øystein Rekdal

Retrospective comparison between a regular and a split-dose protocol of 5-fluorouracil, cisplatin, and mitoxantrone for the treatment of far advanced hepatocellular carcinoma

Open Access
Research article

Chau-Ting Yeh, Hui-Chin Chen, Chang-Mu Sung, Cheng-Lung Hsu, Chen-Chun Lin, Kuang-Tse Pan, Jeng-Hwei Tseng, Chien-Fu Hung

Significant survival improvement of patients with recurrent breast cancer in the periods 2001-2008 vs. 1992-2000

Open Access
Research article

Hideo Shigematsu, Hidetoshi Kawaguchi, Yoshiaki Nakamura, Kimihiro Tanaka, Satoko Shiotani, Chinami Koga, Sumiko Nishimura, Kenichi Taguchi, Kenichi Nishiyama, Shinji Ohno

A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival

Open Access
Research article

Jyotsna Batra, Christina M Nagle, Tracy O'Mara, Melanie Higgins, Ying Dong, Olivia L Tan, Felicity Lose, Lene Marie Skeie, Srilakshmi Srinivasan, Kelly L Bolton, Honglin Song, Susan J Ramus, Simon A Gayther, Paul DP Pharoah, Mary-Anne Kedda, Amanda B Spurdle, Judith A Clements

Latexin expression is downregulated in human gastric carcinomas and exhibits tumor suppressor potential

Open Access
Research article

Yong Li, Zhuoma Basang, Huirong Ding, Zheming Lu, Tao Ning, Haoran Wei, Hong Cai, Yang Ke

Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer

Open Access
Research article

Akira Ooki, Keishi Yamashita, Shiro Kikuchi, Shinichi Sakuramoto, Natsuya Katada, Mina Waraya, Hiroshi Kawamata, Hiroshi Nishimiya, Kazunori Nakamura, Masahiko Watanabe

Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

Open Access
Research article

Adam Naguib, James C Cooke, Lisa Happerfield, Lucy Kerr, Laura J Gay, Robert N Luben, Richard Y Ball, Panagiota N Mitrou, Alison McTaggart, Mark J Arends

Vascular normalization in orthotopic glioblastoma following intravenous treatment with lipid-based nanoparticulate formulations of irinotecan (Irinophore C™), doxorubicin (Caelyx®) or vincristine

Open Access
Research article

Maite Verreault, Dita Strutt, Dana Masin, Malathi Anantha, Andrew Yung, Piotr Kozlowski, Dawn Waterhouse, Marcel B Bally, Donald T Yapp

Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines

Open Access
Research article

Stacey L Fossey, Misty D Bear, William C Kisseberth, Michael Pennell, Cheryl A London

Acceptance of oral chemotherapy in breast cancer patients - a survey study

Open Access
Research article

Sarah Schott, Andreas Schneeweiss, Judith Reinhardt, Thomas Bruckner, Christoph Domschke, Christof Sohn, Michael H Eichbaum

Renal cell cancer among African Americans: an epidemiologic review

Open Access
Review

Loren Lipworth, Robert E Tarone, Joseph K McLaughlin

Health-related Quality of life in 640 head and neck cancer survivors after radiotherapy using EORTC QLQ-C30 and QLQ-H&N35 questionnaires

Open Access
Research article

Stephen Wan Leung, Tsair-Fwu Lee, Chih-Yen Chien, Pei-Ju Chao, Wen-Ling Tsai, Fu-Min Fang

Evaluating the impact of Relative Total Dose Intensity (RTDI) on patients' short and long-term outcome in taxane- and anthracycline-based chemotherapy of metastatic breast cancer- a pooled analysis

Open Access
Research article

Sibylle Loibl, Tomas Skacel, Valentina Nekljudova, Hans Joachim Lück, Matthias Schwenkglenks, Thomas Brodowicz, Christoph Zielinski, Gunter von Minckwitz

Does comorbidity explain the ethnic inequalities in cervical cancer survival in New Zealand? A retrospective cohort study

Open Access
Research article

Naomi Brewer, Barry Borman, Diana Sarfati, Mona Jeffreys, Steven T Fleming, Soo Cheng, Neil Pearce

Prospective evaluation of prognostic factors uPA/PAI-1 in node-negative breast cancer: Phase III NNBC3-Europe trial (AGO, GBG, EORTC-PBG) comparing 6 × FEC versus 3 × FEC/3 × Docetaxel

Open Access
Study protocol

Eva J Kantelhardt, Martina Vetter, Marcus Schmidt, Corinne Veyret, Doris Augustin, Volker Hanf, Christoph Meisner, Daniela Paepke, Manfred Schmitt, Fred Sweep, Gunter von Minckwitz, Pierre-Marie Martin, Fritz Jaenicke, Christoph Thomssen, Nadia Harbeck

Detection of erbB2 copy number variations in plasma of patients with esophageal carcinoma

Open Access
Research article

Immacolata Andolfo, Giuseppe Petrosino, Loredana Vecchione, Pasqualino De Antonellis, Mario Capasso, Donatella Montanaro, Marica Gemei, Giancarlo Troncone, Achille Iolascon, Michele Orditura, Fortunato Ciardiello, Fernando De Vita, Massimo Zollo

Does age matter? - A MRI study on peritumoral edema in newly diagnosed primary glioblastoma

Open Access
Research article

Clemens Seidel, Nils Dörner, Matthias Osswald, Antje Wick, Michael Platten, Martin Bendszus, Wolfgang Wick

Inhibition of nuclear factor kappa-B signaling reduces growth in medulloblastoma in vivo

Open Access
Research article

Susan E Spiller, Naomi J Logsdon, Lindsey A Deckard, Harald Sontheimer

Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo

Open Access
Research article

Seung Joon Lee, Candice Krauthauser, Victoria Maduskuie, Paul T Fawcett, James M Olson, Sigrid A Rajasekaran

Cigarette, cigar and pipe smoking, passive smoke exposure, and risk of pancreatic cancer: a population-based study in the San Francisco Bay Area

Open Access
Research article

Gregory J Tranah, Elizabeth A Holly, Furong Wang, Paige M Bracci

Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization

Open Access
Research article

Kuo-Jang Kao, Kai-Ming Chang, Hui-Chi Hsu, Andrew T Huang

Serum levels of MMP-11 correlate with clinical outcome in Chinese patients with advanced gastric adenocarcinoma

Open Access
Research article

Dong Yan, Hong Dai, Jin-Wei Liu

Inflammatory mediators in breast cancer: Coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition

Open Access
Research article

Gali Soria, Maya Ofri-Shahak, Ilana Haas, Neora Yaal-Hahoshen, Leonor Leider-Trejo, Tal Leibovich-Rivkin, Polina Weitzenfeld, Tsipi Meshel, Esther Shabtai, Mordechai Gutman, Adit Ben-Baruch

Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε

Open Access
Research article

Sven-T Liffers, Abdelouahid Maghnouj, Johanna B Munding, René Jackstadt, Ulrike Herbrand, Thomas Schulenborg, Katrin Marcus, Susanne Klein-Scory, Wolff Schmiegel, Irmgard Schwarte-Waldhoff, Helmut E Meyer, Kai Stühler, Stephan A Hahn

Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells

Open Access
Research article

Sheng-Chun Chiu, Mei-Jen Wang, Hsueh-Hui Yang, Shee-Ping Chen, Sung-Ying Huang, Yi-Lin Chen, Shinn-Zong Lin, Horng-Jyh Harn, Cheng-Yoong Pang

Increase in intracellular PGE2 induces apoptosis in Bax-expressing colon cancer cell

Open Access
Research article

Lisenn Lalier, François Pedelaborde, Christophe Braud, Jean Menanteau, François M Vallette, Christophe Olivier

Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)

Open Access
Research article

Meiju Ji, Haixia Guan, Cuixia Gao, Bingyin Shi, Peng Hou

Sentinel lymph node biopsy as guidance for radical trachelectomy in young patients with early stage cervical cancer

Open Access
Research article

Xue-lian Du, Xiu-gui Sheng, Tao Jiang, Qing-shui Li, Hao Yu, Chun-xia Pan, Chun-hua Lu, Cong Wang, Qu-qing Song

Loss of aquaporin-4 expression and putative function in non-small cell lung cancer

Open Access
Research article

Arne Warth, Thomas Muley, Michael Meister, Esther Herpel, Anita Pathil, Hans Hoffmann, Philipp A Schnabel, Christian Bender, Andreas Buness, Peter Schirmacher, Ruprecht Kuner

Randomized controlled phase I/II study to investigate immune stimulatory effects by low dose radiotherapy in primarily operable pancreatic cancer

Open Access
Study protocol

Carmen Timke, Hubertus Schmitz Winnenthal, Felix Klug, Falk FF Roeder, Andreas Bonertz, Christoph Reissfelder, Nathalie Rochet, Moritz Koch, Christine Tjaden, Markus W Buechler, Juergen Debus, Jens Werner, Philipp Beckhove, Jürgen Weitz, Peter E Huber

Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer

Open Access
Research article

Chen-Yun Yeh, Shin-Mei Shin, Hsuan-Heng Yeh, Tsung-Jung Wu, Jyh-Wei Shin, Tsuey-Yu Chang, Giri Raghavaraju, Chung-Ta Lee, Jung-Hsien Chiang, Vincent S Tseng, Yuan-Chii G Lee, Cheng-Huang Shen, Nan-Haw Chow, Hsiao-Sheng Liu

Diagnosis delay of breast cancer and its associated factors in Malaysian women

Open Access
Research article

Bachok Norsa'adah, Krishna G Rampal, Mohd A Rahmah, Nyi N Naing, Biswa M Biswal

Increased expression of transcription factor TFAP2α correlates with chemosensitivity in advanced bladder cancer

Open Access
Research article

Iver Nordentoft, Lars Dyrskjøt, Julie S Bødker, Peter J Wild, Arndt Hartmann, Simone Bertz, Jan Lehmann, Torben F Ørntoft, Karin Birkenkamp-Demtroder

Income level and regional policies, underlying factors associated with unwarranted variations in conservative breast cancer surgery in Spain

Open Access
Research article

Manuel Ridao-López, Sandra García-Armesto, Begoña Abadía-Taira, Salvador Peiró-Moreno, Enrique Bernal-Delgado

The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism

Open Access
Research article

Fernando J Reyes-Zurita, Gisela Pachón-Peña, Daneida Lizárraga, Eva E Rufino-Palomares, Marta Cascante, José A Lupiáñez

WEE1 inhibition sensitizes osteosarcoma to radiotherapy

Open Access
Research article

Jantine PosthumaDeBoer, Thomas Würdinger, Harm CA Graat, Victor W van Beusechem, Marco N Helder, Barend J van Royen, Gertjan JL Kaspers

Influence of family size and birth order on risk of cancer: a population-based study

Open Access
Research article

Melanie Bevier, Marianne Weires, Hauke Thomsen, Jan Sundquist, Kari Hemminki

Whole brain radiotherapy after local treatment of brain metastases in melanoma patients - a randomised phase III trial

Open Access
Study protocol

Gerald Fogarty, Rachael L Morton, Janette Vardy, Anna K Nowak, Catherine Mandel, Peta M Forder, Angela Hong, George Hruby, Bryan Burmeister, Brindha Shivalingam, Haryana Dhillon, John F Thompson

Applying strategies from libertarian paternalism to decision making for prostate specific antigen (PSA) screening

Open Access
Debate

David C Wheeler, Konrad M Szymanski, Amanda Black, David E Nelson

Isomalto oligosaccharide sulfate inhibits tumor growth and metastasis of hepatocellular carcinoma in nude mice

Open Access
Research article

Chun-Li Xiao, Zhong-Hua Tao, Lin Guo, Wei-Wei Li, Jin-Liang Wan, Hui-Chuan Sun, Lu Wang, Zhao-You Tang, Jia Fan, Wei-Zhong Wu

CD248 facilitates tumor growth via its cytoplasmic domain

Open Access
Research article

Margarida Maia, Astrid DeVriese, Tom Janssens, Michaël Moons, Rik J Lories, Jan Tavernier, Edward M Conway

A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone

Open Access
Research article

Jeffrey D Altenburg, Andrew A Bieberich, Colin Terry, Kevin A Harvey, Justin F VanHorn, Zhidong Xu, V Jo Davisson, Rafat A Siddiqui

Genetic polymorphisms of DNA double strand break gene Ku70 and gastric cancer in Taiwan

Open Access
Research article

Mei-Due Yang, Hwei-Chung Wang, Wen-Shin Chang, Chia-Wen Tsai, Da-Tian Bau

Admission of advanced lung cancer patients to intensive care unit: A retrospective study of 76 patients

Open Access
Research article

Claire Andréjak, Nicolas Terzi, Stéphanie Thielen, Emmanuel Bergot, Gérard Zalcman, Pierre Charbonneau, Vincent Jounieaux

Socioeconomic status and the incidence of non-central nervous system childhood embryonic tumours in Brazil

Open Access
Research article

Beatriz de Camargo, Juliana Moreira de Oliveira Ferreira, Rejane de Souza Reis, Sima Ferman, Marceli de Oliveira Santos, Maria S Pombo-de-Oliveira

The prognostic effect of ethnicity for gastric and esophageal cancer: the population-based experience in British Columbia, Canada

Open Access
Research article

Morteza Bashash, T Greg Hislop, Amil M Shah, Nhu Le, Angela Brooks-Wilson, Chris D Bajdik

Adenoviral infectivity of exfoliated viable cells in urine: Implications for the detection of bladder cancer

Open Access
Research article

Anuradha Murali, Laura Kasman, Christina Voelkel-Johnson

Genes Associated With Prognosis After Surgery For Malignant Pleural Mesothelioma Promote Tumor Cell Survival In Vitro

Open Access
Research article

Gavin J Gordon, Raphael Bueno, David J Sugarbaker

Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells

Open Access
Research article

Guozhu Chen, Xuhui Zhang, Ming Zhao, Yan Wang, Xiang Cheng, Di Wang, Yuanji Xu, Zhiyan Du, Xiaodan Yu

G protein-coupled receptor kinase 5 mediates Tazarotene-induced gene 1-induced growth suppression of human colon cancer cells

Open Access
Research article

Chang-Chieh Wu, Fu-Ming Tsai, Rong-Yaun Shyu, Ya-Ming Tsai, Chun-Hua Wang, Shun-Yuan Jiang

Thymidine Phosphorylase/β-tubulin III expressions predict the response in Chinese advanced gastric cancer patients receiving first-line capecitabine plus paclitaxel

Open Access
Research article

Jing Gao, Ming Lu, Jing-wei Yu, Yan-yan Li, Lin Shen

HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop

Open Access
Research article

Zanobia A Syed, Weihong Yin, Kendall Hughes, Jennifer N Gill, Runhua Shi, John L Clifford

Treatment of malignant sinonasal tumours with intensity-modulated radiotherapy (IMRT) and carbon ion boost (C12)

Open Access
Study protocol

Alexandra D Jensen, Anna V Nikoghosyan, Christine Windemuth-Kieselbach, Jürgen Debus, Marc W Münter

Erratum to: Association of the germline TP53 R337H mutation with breast cancer in southern Brazil

Open Access
Erratum

Juliana G Assumpção, Ana Luíza Seidinger, Maria José Mastellato, Raul C Ribeiro, Gerard P Zambetti, Ramapriya Ganti, Kumar Srivastava, Sheila Shurtleff, Deqing Pei, Luiz Carlos Zeferino, Rozany M Dufloth, Silvia Regina Brandalise, José Andres Yunes

Growth of breast cancer recurrences assessed by consecutive MRI

Open Access
Research article

Ingrid Millet, Emmanuelle Bouic-Pages, Denis Hoa, David Azria, Patrice Taourel

Luminal and basal-like breast cancer cells show increased migration induced by hypoxia, mediated by an autocrine mechanism

Open Access
Research article

Melanie J Voss, Mischa F Möller, Desmond G Powe, Bernd Niggemann, Kurt S Zänker, Frank Entschladen

Disseminating a smoking cessation intervention to childhood and young adult cancer survivors: baseline characteristics and study design of the partnership for health-2 study

Open Access
Research article

Janet S de Moor, Elaine Puleo, Jennifer S Ford, Mark Greenberg, David C Hodgson, Vida L Tyc, Jamie Ostroff, Lisa R Diller, Andrea Gurmankin Levy, Kim Sprunck-Harrild, Karen M Emmons

The association of quality of life with potentially remediable disruptions of circadian sleep/activity rhythms in patients with advanced lung cancer

Open Access
Research article

James F Grutsch, Carol Ferrans, Patricia A Wood, Jovelyn Du-Quiton, Dinah Faith T Quiton, Justin L Reynolds, Christine M Ansell, Eun Young Oh, Mary Ann Daehler, Robert D Levin, Donald P Braun, Digant Gupta, Christopher G Lis, William JM Hrushesky

Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4

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Research article

Saskia E Rademakers, Jasper Lok, Albert J van der Kogel, Johan Bussink, Johannes HAM Kaanders

Extragenital Müllerian adenosarcoma with pouch of Douglas location

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Case report

Tito S Patrelli, Enrico M Silini, Salvatore Gizzo, Roberto Berretta, Laura Franchi, Elena Thai, Adolf Lukanovic, Giovanni B Nardelli, Alberto Bacchi Modena

Analysis of the Mitogen-activated protein kinase kinase 4 (MAP2K4) tumor suppressor gene in ovarian cancer

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Research article

Sally J Davis, David YH Choong, Manasa Ramakrishna, Georgina L Ryland, Ian G Campbell, Kylie L Gorringe

β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis

Open Access
Research article

Jing Liu, Ye Zhang, Jinglei Qu, Ling Xu, Kezuo Hou, Jingdong Zhang, Xiujuan Qu, Yunpeng Liu

MMP28 (epilysin) as a novel promoter of invasion and metastasis in gastric cancer

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Pan Jian, Tao Yanfang, Zhou Zhuan, Wang Jian, Zhu Xueming, Ni Jian

MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis

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Research article

Yan Wan, Wei Wu, Zhihua Yin, Peng Guan, Baosen Zhou

Effects on quality of life, anti-cancer responses, breast conserving surgery and survival with neoadjuvant docetaxel: a randomised study of sequential weekly versus three-weekly docetaxel following neoadjuvant doxorubicin and cyclophosphamide in women with primary breast cancer

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Research article

Leslie G Walker, Jennifer M Eremin, Mark M Aloysius, Wichai Vassanasiri, Mary B Walker, Mohamed El-Sheemy, Ged Cowley, Jeanette Beer, Srila Samphao, Janice Wiseman, Jibril A Jibril, David Valerio, David J Clarke, Mujahid Kamal, Gerald W Thorpe, Karin Baria, Oleg Eremin

Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group

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Research article

Harry H Yoon, Paul J Catalano, Kathleen M Murphy, Todd C Skaar, Santosh Philips, Mark Powell, Elizabeth A Montgomery, Michael J Hafez, Steven M Offer, Geoffrey Liu, Stephen J Meltzer, Xifeng Wu, Arlene A Forastiere, Al B Benson, Lawrence R Kleinberg, Michael K Gibson

Phase II study of induction chemotherapy with TPF followed by radioimmunotherapy with Cetuximab and intensity-modulated radiotherapy (IMRT) in combination with a carbon ion boost for locally advanced tumours of the oro-, hypopharynx and larynx - TPF-C-HIT

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Study protocol

Alexandra D Jensen, Jürgen Krauss, Karin Potthoff, Almaz Desta, Gregor Habl, Athanasios Mavtratzas, Christine Windemuth-Kiesselbach, Jürgen Debus, Marc W Münter

Down-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis

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Research article

Sheng Zhang, Yan Wang, Shun-Dong Dai, En-Hua Wang

Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: Role of uric acid accumulation in gemcitabine-induced MICA/B expression

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Research article

Xiulong Xu, Geetha S Rao, Veronika Groh, Thomas Spies, Paolo Gattuso, Howard L Kaufman, Janet Plate, Richard A Prinz

Process of distant lymph node metastasis in colorectal carcinoma: Implication of extracapsular invasion of lymph node metastasis

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Takaaki Fujii, Yuichi Tabe, Reina Yajima, Satoru Yamaguchi, Soichi Tsutsumi, Takayuki Asao, Hiroyuki Kuwano

Bilateral ovarian teratoma complicated with carcinosarcoma in a 68 year old woman: a case report

Open Access
Case report

S Shanmughapriya, G SenthilKumar, K Balakrishnan, N Vasanthi, K Vinodhini, K Natarajaseenivasan

SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation

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Tolga Acun, Emin Oztas, Tamer Yagci, Mustafa C Yakicier

Laryngeal embryonal rhabdomyosarcoma in an adult - A case presentation in the eyes of geneticists and clinicians

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Case report

Wojciech Kukwa, Piotr Wojtowicz, Beata Jagielska, Grzegorz Sobczyk, Andrzej Kukwa, Anna M Czarnecka

STAT6 expression in glioblastoma promotes invasive growth

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Barbara C Merk, Jennifer L Owens, Maria-Beatriz S Lopes, Corinne M Silva, Isa M Hussaini

Interleukin-11-induced capillary leak syndrome in primary hepatic carcinoma patients with thrombocytopenia

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Case report

Wang Kai-Feng, Pan Hong-Ming, Lou Hai-Zhou, Shen Li-Rong, Zhu Xi-Yan

The synthetic peptide P111-136 derived from the C-terminal domain of heparin affin regulatory peptide inhibits tumour growth of prostate cancer PC-3 cells

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Research article

Yamina Hamma-Kourbali, Oya Bermek, Isabelle Bernard-Pierrot, Racha Karaky, Dominique Martel-Renoir, Sophie Frechault, José Courty, Jean Delbé

Societal Costs and Benefits of Treatment with Trastuzumab in Patients with Early HER2neu-Overexpressing Breast Cancer in Singapore

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Research article

Gilberto de Lima Lopes Jr

RETRACTED ARTICLE: Y-box protein-1/p18 fragment identifies malignancies in patients with chronic liver disease

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Research article

Frank Tacke, Nicolas Kanig, Abdelaziz En-Nia, Thilo Kaehne, Christiane S Eberhardt, Victoria Shpacovitch, Christian Trautwein, Peter R Mertens

Diagnostic performance of contrast enhanced CT and 18F-FDG PET/CT in suspicious recurrence of biliary tract cancer after curative resection

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Research article

Yun-Gyoo Lee, Sae-Won Han, Do-Youn Oh, Eui Kyu Chie, Jin-Young Jang, Seock-Ah Im, Tae-You Kim, Sun-Whe Kim, Sung Whan Ha, Yung-Jue Bang

Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability

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Research article

Muhan Chen, Jian-Dong Huang, Hong Kui Deng, Suisui Dong, Wen Deng, Sze Lan Tsang, Michael SY Huen, Leilei Chen, Tong Zan, Gui-Xia Zhu, Xin-Yuan Guan

Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior

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Research article

Benoit Hedan, Rachael Thomas, Alison Motsinger-Reif, Jerome Abadie, Catherine Andre, John Cullen, Matthew Breen

Relevance of circulating nucleosomes and oncological biomarkers for predicting response to transarterial chemoembolization therapy in liver cancer patients

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Research article

Nikolaus Kohles, Dorothea Nagel, Dietrich Jüngst, Jürgen Durner, Petra Stieber, Stefan Holdenrieder

P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation

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Research article

Kelly A Avery-Kiejda, Nikola A Bowden, Amanda J Croft, Lyndee L Scurr, Carla F Kairupan, Katie A Ashton, Bente A Talseth-Palmer, Helen Rizos, Xu D Zhang, Rodney J Scott, Peter Hersey

Prognostic significance of IL-6 and IL-8 ascites levels in ovarian cancer patients

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Research article

Denis Lane, Isabelle Matte, Claudine Rancourt, Alain Piché

In vitro anti-angiogenic properties of LGD1069, a selective retinoid X-receptor agonist through down-regulating Runx2 expression on Human endothelial cells

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Research article

Jianjiang Fu, Wei Wang, Yu-Hui Liu, Hong Lu, Yongming Luo

Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: A novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma

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Research article

Irene Centeno, Pilar Blay, Iñigo Santamaría, Aurora Astudillo, Ana S Pitiot, Fernando G Osorio, Patricia González-Arriaga, Fernando Iglesias, Primitiva Menéndez, Adonina Tardón, Jose M Freije, Milagros Balbín

Mitochondrial targeted catalase suppresses invasive breast cancer in mice

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Jorming Goh, Linda Enns, Soroosh Fatemie, Heather Hopkins, John Morton, Christina Pettan-Brewer, Warren Ladiges

Complementary and alternative medicine use in oncology: A questionnaire survey of patients and health care professionals

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Kah Hoong Chang, Rachel Brodie, Mei Ann Choong, Karl J Sweeney, Michael J Kerin

Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas

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Research article

Monika Golinska, Helen Troy, Yuen-Li Chung, Paul M McSheehy, Manuel Mayr, Xiaoke Yin, Lucy Ly, Kaye J Williams, Rachel E Airley, Adrian L Harris, John Latigo, Meg Perumal, Eric O Aboagye, David Perrett, Marion Stubbs, John R Griffiths

Chemotherapy followed by surgery versus surgery alone in patients with resectable oesophageal squamous cell carcinoma: Long-term results of a randomized controlled trial

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Research article

Jurjen J Boonstra, Tjebbe C Kok, Bas PL Wijnhoven, Mark van Heijl, Mark I van Berge Henegouwen, Fiebo JW ten Kate, Peter D Siersema, Winand NM Dinjens, Jan JB van Lanschot, Hugo W Tilanus, Ate van der Gaast

Phase II study of the combination carboplatin plus celecoxib in heavily pre-treated recurrent ovarian cancer patients

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Research article

Francesco Legge, Amelia Paglia, Marco D'Asta, Gilda Fuoco, Giovanni Scambia, Gabriella Ferrandina

Cost-effectiveness of early detection of breast cancer in Catalonia (Spain)

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Research article

Misericordia Carles, Ester Vilaprinyo, Francesc Cots, Aleix Gregori, Roger Pla, Rubén Román, Maria Sala, Francesc Macià, Xavier Castells, Montserrat Rue

Re-surgery and chest wall re-irradiation for recurrent breast cancer - a second curative approach

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Arndt-Christian Müller, Franziska Eckert, Vanessa Heinrich, Michael Bamberg, Sara Brucker, Thomas Hehr

Systemic chemotherapy for treatment of advanced small bowel adenocarcinoma with prognostic factor analysis: retrospective study

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Research article

Dong Hoe Koo, Sung-Cheol Yun, Yong Sang Hong, Min-Hee Ryu, Jae-Lyun Lee, Heung-Moon Chang, Baek-Yeol Ryoo, Yoon-Koo Kang, Tae Won Kim

Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression

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Research article

Chelsea R Tieszen, Alicia A Goyeneche, BreeAnn N Brandhagen, Casey T Ortbahn, Carlos M Telleria

Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer

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Ian F Robey, Natasha K Martin

A short-term in vivo model for giant cell tumor of bone

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Research article

Maurice Balke, Anna Neumann, Károly Szuhai, Konstantin Agelopoulos, Christian August, Georg Gosheger, Pancras CW Hogendoorn, Nick Athanasou, Horst Buerger, Martin Hagedorn

Retrospective exploratory analysis of VEGF polymorphisms in the prediction of benefit from first-line FOLFIRI plus bevacizumab in metastatic colorectal cancer

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Research article

Fotios Loupakis, Annamaria Ruzzo, Lisa Salvatore, Chiara Cremolini, Gianluca Masi, Paolo Frumento, Marta Schirripa, Vincenzo Catalano, Nadia Galluccio, Emanuele Canestrari, Bruno Vincenzi, Daniele Santini, Katia Bencardino, Vincenzo Ricci, Mariangela Manzoni, Marco Danova, Giuseppe Tonini, Mauro Magnani, Alfredo Falcone, Francesco Graziano

Importance of pre-analytical steps for transcriptome and RT-qPCR analyses in the context of the phase II randomised multicentre trial REMAGUS02 of neoadjuvant chemotherapy in breast cancer patients

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Research article

Patricia de Cremoux, Fabien Valet, David Gentien, Jacqueline Lehmann-Che, Véronique Scott, Carine Tran-Perennou, Catherine Barbaroux, Nicolas Servant, Sophie Vacher, Brigitte Sigal-Zafrani, Marie-Christine Mathieu, Philippe Bertheau, Jean-Marc Guinebretière, Bernard Asselain, Michel Marty, Frédérique Spyratos

The roles of herbal remedies in survival and quality of life among long-term breast cancer survivors - results of a prospective study

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Huiyan Ma, Catherine L Carpenter, Jane Sullivan-Halley, Leslie Bernstein

Circulating levels of cell adhesion molecule L1 as a prognostic marker in gastrointestinal stromal tumor patients

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Hilke Zander, Tamina Rawnaq, Max von Wedemeyer, Michael Tachezy, Miriam Kunkel, Gerrit Wolters, Maximilian Bockhorn, Melitta Schachner, Jakob R Izbicki, Jussuf Kaifi

Attenuated expression of HRH4 in colorectal carcinomas: a potential influence on tumor growth and progression

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Research article

Zhengyu Fang, Wantong Yao, Yi Xiong, Jiana Li, Li Liu, Lei Shi, Wei Zhang, Chao Zhang, Liping Nie, Jun Wan

Variations in Mre11/Rad50/Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel

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Research article

Kristen M Garner, Alan Eastman

MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines

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Research article

Hege O Ohnstad, Erik B Paulsen, Paul Noordhuis, Marianne Berg, Ragnhild A Lothe, Lyubomir T Vassilev, Ola Myklebost

Down regulation of E-Cadherin (ECAD) - a predictor for occult metastatic disease in sentinel node biopsy of early squamous cell carcinomas of the oral cavity and oropharynx

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Research article

Gerhard F Huber, Lena Züllig, Alex Soltermann, Matthias Roessle, Nicole Graf, Stephan K Haerle, Gabriela Studer, Wolfram Jochum, Holger Moch, Sandro J Stoeckli

NDRG2 inhibits hepatocellular carcinoma adhesion, migration and invasion by regulating CD24 expression

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Research article

Jin Zheng, Yan Li, Jiandong Yang, Qiang Liu, Ming Shi, Rui Zhang, Hengjun Shi, Qinyou Ren, Ji Ma, Hang Guo, Yurong Tao, Yan Xue, Ning Jiang, Libo Yao, Wenchao Liu

Clinical relevance of DNA microarray analyses using archival formalin-fixed paraffin-embedded breast cancer specimens

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Al Muktafi Sadi, Dong-Yu Wang, Bruce J Youngson, Naomi Miller, Scott Boerner, Susan J Done, Wey L Leong

Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer

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Research article

Lucy Heinemann, Guy R Simpson, Angela Boxall, Timothy Kottke, Kate L Relph, Richard Vile, Alan Melcher, Robin Prestwich, Kevin J Harrington, Richard Morgan, Hardev S Pandha

Lung cancer stage at diagnosis: Individual associations in the prospective VITamins and lifestyle (VITAL) cohort

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Research article

Christopher G Slatore, Michael K Gould, David H Au, Mark E Deffebach, Emily White

Detection of antibodies directed at M. hyorhinis p37 in the serum of men with newly diagnosed prostate cancer

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Research article

Cydney Urbanek, Steve Goodison, Myron Chang, Stacy Porvasnik, Noburo Sakamoto, Chen-zhong Li, Susan K Boehlein, Charles J Rosser

GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells

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Tesfom Abrhale, Angela Brodie, Gauri Sabnis, Luciana Macedo, Changsheng Tian, Binbin Yue, Ginette Serrero

Limited importance of the dominant-negative effect of TP53missense mutations

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Research article

Ewelina Stoczynska-Fidelus, Malgorzata Szybka, Sylwester Piaskowski, Michal Bienkowski, Krystyna Hulas-Bigoszewska, Mateusz Banaszczyk, Izabela Zawlik, Dorota Jesionek-Kupnicka, Radzislaw Kordek, Pawel P Liberski, Piotr Rieske

Prognostic value of the expression of C-Chemokine Receptor 6 and 7 and their ligands in non-metastatic breast cancer

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Research article

Philippe A Cassier, Isabelle Treilleux, Thomas Bachelot, Isabelle Ray-Coquard, Nathalie Bendriss-Vermare, Christine Ménétrier-Caux, Olivier Trédan, Sophie Goddard-Léon, Jean-Jacques Pin, Hervé Mignotte, Clarisse Bathélémy-Dubois, Christophe Caux, Serge Lebecque, Jean-Yves Blay

Clinical symptoms and chemotherapy completion in elderly patients with newly diagnosed acute leukemia: a retrospective comparison study with a younger cohort

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Rong Hu, Yong Wu, Xiaoying Jiang, Wenteng Zhang, Le Xu

Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8

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Research article

Giovanna E Carpagnano, Grazia P Palladino, Donato Lacedonia, Anna Koutelou, Silvio Orlando, Maria P Foschino-Barbaro

Oncoprotein DEK as a tissue and urinary biomarker for bladder cancer

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Antara Datta, Martin E Adelson, Yakov Mogilevkin, Eli Mordechai, Abraham A Sidi, Jason P Trama

COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status

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Research article

Annika Gustafsson Asting, Helena Carén, Marianne Andersson, Christina Lönnroth, Kristina Lagerstedt, Kent Lundholm

Platelet factor-4 and its p17-70 peptide inhibit myeloma proliferation and angiogenesis in vivo

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Research article

Longjiang Yang, Juan Du, Jian Hou, Hua Jiang, Jianfeng Zou

Myofibrillogenesis regulator 1 (MR-1) is a novel biomarker and potential therapeutic target for human ovarian cancer

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Research article

Renquan Lu, Min Sun, Jingjing Feng, Xiang Gao, Lin Guo

A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma

Open Access
Research article

Lisa Mirabello, Kai Yu, Sonja I Berndt, Laurie Burdett, Zhaoming Wang, Salma Chowdhury, Kedest Teshome, Arinze Uzoka, Amy Hutchinson, Tom Grotmol, Chester Douglass, Richard B Hayes, Robert N Hoover, Sharon A Savage

Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity

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Research article

Wentao Qi, Christopher R Weber, Kaarin Wasland, Suzana D Savkovic

Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival

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Research article

Sara Huerta-Yepez, Nam K Yoon, Angeles Hernandez-Cueto, Vei Mah, Clara M Rivera-Pazos, Devasis Chatterjee, Mario I Vega, Erin L Maresh, Steve Horvath, David Chia, Benjamin Bonavida, Lee Goodglick

Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related molecules

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Research article

Sue Youn Kim, Jiyeon Yoon, Young San Ko, Mee Soo Chang, Jong-Wan Park, Hee Eun Lee, Min A Kim, Ji Hun Kim, Woo Ho Kim, Byung Lan Lee

Lung cancer in HIV patients and their parents: A Danish cohort study

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Research article

Frederik N Engsig, Gitte Kronborg, Carsten S Larsen, Gitte Pedersen, Court Pedersen, Jan Gerstoft, Niels Obel

Low expression of aldehyde deyhdrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer

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Research article

Christoph Kahlert, Frank Bergmann, Janine Beck, Thilo Welsch, Carolin Mogler, Esther Herpel, Shamik Dutta, Thomas Niemietz, Moritz Koch, Jürgen Weitz

Literature survey on epidemiology and pathology of gangliocytic paraganglioma

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Yoichiro Okubo, Megumi Wakayama, Tetsuo Nemoto, Kanako Kitahara, Haruo Nakayama, Kazutoshi Shibuya, Tomoyuki Yokose, Manabu Yamada, Kayoko Shimodaira, Daisuke Sasai, Takao Ishiwatari, Masaru Tsuchiya, Nobuyuki Hiruta

T lymphocytes derived from human cord blood provide effective antitumor immunotherapy against a human tumor

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Research article

Yong-Soo Lee, Tae-Sik Kim, Dong-Ku Kim

Cervical Mullerian Adenosarcoma with heterologous sarcomatous overgrowth: a fourth case and review of literature

Open Access
Case report

Tito Silvio Patrelli, Salvatore Gizzo, Stefania Di Gangi, Giorgia Guidi, Mario Rondinelli, Giovanni Battista Nardelli

Efficacy of a referral and physical activity program for survivors of prostate cancer [ENGAGE]: Rationale and design for a cluster randomised controlled trial

Open Access
Study protocol

Patricia M Livingston, Jo Salmon, Kerry S Courneya, Cadeyrn J Gaskin, Melinda Craike, Mari Botti, Suzanne Broadbent, Bridie Kent

Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study

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Research article

Ju-Fang Shi, Karen Canfell, Jie-Bin Lew, Fang-Hui Zhao, Rosa Legood, Yan Ning, Leonardo Simonella, Li Ma, Yoon-Jung Kang, Yong-Zhen Zhang, Megan A Smith, Jun-Feng Chen, Xiang-Xian Feng, You-Lin Qiao

Magnetic resonance imaging for lung cancer detection: Experience in a population of more than 10,000 healthy individuals

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Research article

Nai-Yuan Wu, Hui-Cheng Cheng, James S Ko, Yu-Chen Cheng, Po-Wei Lin, Wei-Chan Lin, Cheng-Yen Chang, Der-Ming Liou

Renal cell carcinoma primary cultures maintain genomic and phenotypic profile of parental tumor tissues

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Research article

Ingrid Cifola, Cristina Bianchi, Eleonora Mangano, Silvia Bombelli, Fabio Frascati, Ester Fasoli, Stefano Ferrero, Vitalba Di Stefano, Maria A Zipeto, Fulvio Magni, Stefano Signorini, Cristina Battaglia, Roberto A Perego

FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells

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Research article

Hyung-Ok Lee, Stefanie R Mullins, Janusz Franco-Barraza, Matthildi Valianou, Edna Cukierman, Jonathan D Cheng

c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells

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Yinghua Chen, Jinhua Xu, Stanley Borowicz, Cindy Collins, Dezheng Huo, Olufunmilayo I Olopade

PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib

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Research article

Leiping Wang, Qunling Zhang, Jian Zhang, Si Sun, Haiyi Guo, Zhen Jia, Biyun Wang, Zhimin Shao, Zhonghua Wang, Xichun Hu

Healthcare costs in women with metastatic breast cancer receiving chemotherapy as their principal treatment modality

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Research article

Montserrat Vera-Llonch, Derek Weycker, Andrew Glass, Sue Gao, Rohit Borker, Angie Qin, Gerry Oster

Prognostic value of hematogenous dissemination and biological profile of the tumor in early breast cancer patients: A prospective observational study

Open Access
Research article

Montserrat Solá, Mireia Margelí, Eva Castellá, Juan F Julian, Miquel Rull, Josep M Gubern, Antonio Mariscal, Agustí Barnadas, Manuel Fraile

Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma

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Research article

Jian Ma, Shuiliang Wang, Ming Zhao, Xin-Sheng Deng, Choon-Kee Lee, Xiao-Dan Yu, Bolin Liu

Gβγ subunits inhibit Epac-induced melanoma cell migration

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Research article

Erdene Baljinnyam, Masanari Umemura, Mariana S De Lorenzo, Lai-Hua Xie, Martha Nowycky, Mizuka Iwatsubo, Suzie Chen, James S Goydos, Kousaku Iwatsubo

Increased incidence of myelodysplastic syndrome and acute myeloid leukemia following breast cancer treatment with radiation alone or combined with chemotherapy: a registry cohort analysis 1990-2005

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Research article

Henry G Kaplan, Judith A Malmgren, Mary K Atwood

Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas

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Research article

Peeter Karihtala, Saila Kauppila, Ylermi Soini, Arja-Jukkola-Vuorinen

Expression of Tissue factor in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix: Implications for immunotherapy with hI-con1, a factor VII-IgGFcchimeric protein targeting tissue factor

Open Access
Research article

Emiliano Cocco, Joyce Varughese, Natalia Buza, Stefania Bellone, Michelle Glasgow, Marta Bellone, Paola Todeschini, Luisa Carrara, Dan-Arin Silasi, Masoud Azodi, Peter E Schwartz, Thomas J Rutherford, Sergio Pecorelli, Charles J Lockwood, Alessandro D Santin

Adjuvant Radio-chemotherapy for extrahepatic biliary tract cancers

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Research article

Marta Bonet Beltrán, Arnaud D Roth, Gilles Mentha, Abdelkarim S Allal

Altered efficacy of AT1R-targeted treatment after spontaneous cancer cell-AT1R upregulation

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Research article

Eleanor I Ager, Shu Wen Wen, Joyna Chan, Way W Chong, Jaclyn H Neo, Christopher Christophi

Peritoneal lymphomatosis confounded by prior history of colon cancer: a case report

Open Access
Case report

Yun Gi Kim, Ji Yeon Baek, Sun Young Kim, Dong Hyeon Lee, Weon Seo Park, Youngmee Kwon, Min Ju Kim, Jeehoon Kang, Joo Myung Lee

Underuse of long-term routine hospital follow-up care in patients with a history of breast cancer?

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Research article

Wenli Lu, Liesbeth Jansen, Michael Schaapveld, Peter C Baas, Theo Wiggers, Geertruida H De Bock

Regulation of gene expression in ovarian cancer cells by luteinizing hormone receptor expression and activation

Open Access
Research article

Juan Cui, Brooke M Miner, Joanna B Eldredge, Susanne W Warrenfeltz, Phuongan Dam, Ying Xu, David Puett

Mental adjustment to cancer and its relation to anxiety, depression, HRQL and survival in patients with laryngeal cancer - A longitudinal study

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Research article

Mia Johansson, Anna Rydén, Caterina Finizia

Protein expression based multimarker analysis of breast cancer samples

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Research article

Angela P Presson, Nam K Yoon, Lora Bagryanova, Vei Mah, Mohammad Alavi, Erin L Maresh, Ayyappan K Rajasekaran, Lee Goodglick, David Chia, Steve Horvath

Association between novel PLCE1variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck

Open Access
Research article

Hongxia Ma, Li-E Wang, Zhensheng Liu, Erich M Sturgis, Qingyi Wei

Sociodemographic gradients in breast and cervical cancer screening in Korea: the Korean National Cancer Screening Survey (KNCSS) 2005-2009

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Research article

Mi Jin Park, Eun-Cheol Park, Kui Son Choi, Jae Kwan Jun, Hoo-Yeon Lee

Clinicopathological and prognostic significance of HER-2/neu and VEGF expression in colon carcinomas

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Research article

Qingguo Li, Daorong Wang, Jing Li, Ping Chen

Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer

Open Access
Research article

Nuh N Rahbari, Thomas Schmidt, Christine S Falk, Ulf Hinz, Magdalene Herber, Ulrich Bork, Markus W Büchler, Jürgen Weitz, Moritz Koch

Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter

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Research article

Mercedes Dávalos-Salas, Mayra Furlan-Magaril, Edgar González-Buendía, Christian Valdes-Quezada, Erandi Ayala-Ortega, Félix Recillas-Targa

Zinc finger protein ZBTB20 expression is increased in hepatocellular carcinoma and associated with poor prognosis

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Research article

Qing Wang, Ye-xiong Tan, Yi-bin Ren, Li-wei Dong, Zhi-fang Xie, Liang Tang, Dan Cao, Wei-ping Zhang, He-ping Hu, Hong-yang Wang

ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-κB-dependent manner

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Research article

Navin R Mahadevan, Jeffrey Rodvold, Gonzalo Almanza, Antonio Fernández Pérez, Matthew C Wheeler, Maurizio Zanetti

Screening for cervical cancer: when theory meets reality

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Commentary

Mari Nygård

P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the Aurora-B Kinase Inhibitor barasertib-hQPA

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Research article

Martin Grundy, Claire Seedhouse, Nigel H Russell, Monica Pallis

A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2genes

Open Access
Technical advance

Heather L Hondow, Stephen B Fox, Gillian Mitchell, Rodney J Scott, Victoria Beshay, Stephen Q Wong, Alexander Dobrovic

Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B Leukemic Cells

Open Access
Research article

Ganchimeg Ishdorj, James B Johnston, Spencer B Gibson

Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice

Open Access
Research article

Melpo Christofidou-Solomidou, Sonia Tyagi, Kay-See Tan, Sarah Hagan, Ralph Pietrofesa, Floyd Dukes, Evguenia Arguiri, Daniel F Heitjan, Charalambos C Solomides, Keith A Cengel

Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk

Open Access
Research article

Luisel J Ricks-Santi, Lara E Sucheston, Yang Yang, Jo L Freudenheim, Claudine J Isaacs, Marc D Schwartz, Ramona G Dumitrescu, Catalin Marian, Jing Nie, Dominica Vito, Stephen B Edge, Peter G Shields

Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/dbobese mice

Open Access
Research article

Masahito Shimizu, Yoichi Yasuda, Hiroyasu Sakai, Masaya Kubota, Daishi Terakura, Atsushi Baba, Tomohiko Ohno, Takahiro Kochi, Hisashi Tsurumi, Takuji Tanaka, Hisataka Moriwaki

The use of erlotinib in daily practice: a study on adherence and patients' experiences

Open Access
Study protocol

Lonneke Timmers, Christel CLM Boons, Dirk Mangnus, Josee E Moes, Eleonora L Swart, Epie Boven, Egbert F Smit, Jacqueline G Hugtenburg

Cost-analysis of XELOX and FOLFOX4 for treatment of colorectal cancer to assist decision-making on reimbursement

Open Access
Research article

Vicki C Tse, Wai Tong Ng, Victor Lee, Anne WM Lee, Daniel TT Chua, June Chau, Sarah M McGhee

Sustained platelet-sparing effect of weekly low dose paclitaxel allows effective, tolerable delivery of extended dose dense weekly carboplatin in platinum resistant/refractory epithelial ovarian cancer

Open Access
Research article

Rohini Sharma, Janet Graham, Sarah Blagden, Hani Gabra

Differences in integrin expression and signaling within human breast cancer cells

Open Access
Research article

Aliakbar Taherian, Xinlei Li, Yongqing Liu, Thomas A Haas

Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts

Open Access
Research article

Takehito Kawakami, Tetsuro Sameshima, Hironobu Hojo, Kaori Koga, Yoshiaki Nakahara, Bryan P Toole, Junji Suzumiya, Yasunori Okada, Akinori Iwasaki, Kazuki Nabeshima

Glioblastoma-derived Leptin Induces Tube Formation and Growth of Endothelial Cells: Comparison with VEGF Effects

Open Access
Research article

Rita Ferla, Maria Bonomi, Laszlo Otvos Jr, Eva Surmacz

Aberrant methylation of N-methyl-D-aspartate receptor type 2B (NMDAR2B) in non-small cell carcinoma

Open Access
Research article

Hajime Tamura, Makoto Suzuki, Yasumitsu Moriya, Hidehisa Hoshino, Tatsuro Okamoto, Shigetoshi Yoshida, Ichiro Yoshino

Trends in colorectal cancer incidence: a period and birth-cohort analysis in a well-defined French population

Open Access
Research article

Marion Chauvenet, Vanessa Cottet, Côme Lepage, Valérie Jooste, Jean Faivre, Anne-Marie Bouvier

An intracellular targeted antibody detects EGFR as an independent prognostic factor in ovarian carcinomas

Open Access
Research article

Aurelia Noske, Michael Schwabe, Wilko Weichert, Silvia Darb-Esfahani, Ann-Christin Buckendahl, Jalid Sehouli, Elena I Braicu, Jan Budczies, Manfred Dietel, Carsten Denkert

Sequential FDG-PET and induction chemotherapy in locally advanced adenocarcinoma of the Oesophago-gastric junction (AEG): The Heidelberg Imaging program in Cancer of the oesophago-gastric junction during Neoadjuvant treatment: HICON trial

Open Access
Study protocol

Sylvie Lorenzen, Carl von Gall, Annika Stange, Georg M Haag, Jürgen Weitz, Uwe Haberkorn, Florian Lordick, Wilko Weichert, Ulrich Abel, Jürgen Debus, Dirk Jäger, Marc W Münter

Simultaneous integrated boost for adjuvant treatment of breast cancer- intensity modulated vs. conventional radiotherapy: The IMRT-MC2 trial

Open Access
Study protocol

Vasileios Askoxylakis, Alexandra D Jensen, Matthias F Häfner, Leonie Fetzner, Florian Sterzing, Joerg Heil, Christof Sohn, Johannes Hüsing, Uta Tiefenbacher, Frederik Wenz, Jürgen Debus, Holger Hof

Effect of a low fat versus a low carbohydrate weight loss dietary intervention on biomarkers of long term survival in breast cancer patients ('CHOICE'): study protocol

Open Access
Study protocol

Scot M Sedlacek, Mary C Playdon, Pamela Wolfe, John N McGinley, Mark R Wisthoff, Elizabeth A Daeninck, Weiqin Jiang, Zongjian Zhu, Henry J Thompson

A simple method for assigning genomic grade to individual breast tumours

Open Access
Software

Kristian Wennmalm, Jonas Bergh

Measuring cancer care coordination: development and validation of a questionnaire for patients

Open Access
Research article

Jane M Young, Jennifer Walsh, Phyllis N Butow, Michael J Solomon, Joanne Shaw

Nottingham Prognostic Index in Triple-Negative Breast Cancer: a reliable prognostic tool?

Open Access
Research article

André Albergaria, Sara Ricardo, Fernanda Milanezi, Vítor Carneiro, Isabel Amendoeira, Daniella Vieira, Jorge Cameselle-Teijeiro, Fernando Schmitt

Combined mRNA expression levels of members of the urokinase plasminogen activator (uPA) system correlate with disease-associated survival of soft-tissue sarcoma patients

Open Access
Research article

Matthias Kotzsch, Viktor Magdolen, Thomas Greither, Matthias Kappler, Matthias Bache, Christine Lautenschläger, Susanne Füssel, Alexander W Eckert, Thomas Luther, Gustavo Baretton, Peter Würl, Helge Taubert

Dose and polymorphic genes xrcc1, xrcc3, gst play a role in the risk of developing erythema in breast cancer patients following single shot partial breast irradiation after conservative surgery

Open Access
Research article

Elisabetta Falvo, Lidia Strigari, Gennaro Citro, Carolina Giordano, Stefano Arcangeli, Antonella Soriani, Daniela D'Alessio, Paola Muti, Giovanni Blandino, Isabella Sperduti, Paola Pinnarò

Intrinsic resistance to tyrosine kinase inhibitors is associated with poor clinical outcome in metastatic renal cell carcinoma

Open Access
Research article

Jonas Busch, Christoph Seidel, Steffen Weikert, Ingmar Wolff, Carsten Kempkensteffen, Lisa Weinkauf, Stefan Hinz, Ahmed Magheli, Kurt Miller, Viktor Grünwald

Protein-bound polysaccharide from Phellinus linteus inhibits tumor growth, invasion, and angiogenesis and alters Wnt/β-catenin in SW480 human colon cancer cells

Open Access
Research article

Kyoung-Sub Song, Ge Li, Jong-Seok Kim, Kaipeng Jing, Tae-Dong Kim, Jin-Pyo Kim, Seung-Bo Seo, Jae-Kuk Yoo, Hae-Duck Park, Byung-Doo Hwang, Kyu Lim, Wan-Hee Yoon

E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion

Open Access
Research article

Hilary Glen, Susan Mason, Hitesh Patel, Kenneth Macleod, Valerie G Brunton

Radiotherapy may improve overall survival of patients with T3/T4 transitional cell carcinoma of the renal pelvis or ureter and delay bladder tumour relapse

Open Access
Research article

Bing Chen, Zhao-Chong Zeng, Guo-Min Wang, Li Zhang, Zong-Ming Lin, Li-An Sun, Tong-Yu Zhu, Li-Li Wu, Jian-Ying Zhang, Yuan Ji

A cyclopalladated complex interacts with mitochondrial membrane thiol-groups and induces the apoptotic intrinsic pathway in murine and cisplatin-resistant human tumor cells

Open Access
Research article

Fabiana A Serrano, Alisson L Matsuo, Priscila T Monteforte, Alexandre Bechara, Soraya S Smaili, Débora P Santana, Tiago Rodrigues, Felipe V Pereira, Luis S Silva, Joel Machado Jr, Edson L Santos, João B Pesquero, Rafael M Martins, Luiz R Travassos, Antonio CF Caires, Elaine G Rodrigues

High resolution melting analysis for a rapid identification of heterozygous and homozygous sequence changes in the MUTYH gene

Open Access
Technical advance

Rossella Tricarico, Francesca Crucianelli, Antonio Alvau, Claudio Orlando, Roberta Sestini, Francesco Tonelli, Rosa Valanzano, Maurizio Genuardi

Integrated genomics of ovarian xenograft tumor progression and chemotherapy response

Open Access
Research article

Ashley Stuckey, Andrew Fischer, Daniel H Miller, Sara Hillenmeyer, Kyu K Kim, Anna Ritz, Rakesh K Singh, Benjamin J Raphael, Laurent Brard, Alexander S Brodsky

Open versus laparoscopically-assisted oesophagectomy for cancer: a multicentre randomised controlled phase III trial - the MIRO trial

Open Access
Study protocol

Nicolas Briez, Guillaume Piessen, Franck Bonnetain, Cécile Brigand, Nicolas Carrere, Denis Collet, Christophe Doddoli, Renaud Flamein, Jean-Yves Mabrut, Bernard Meunier, Simon Msika, Thierry Perniceni, Frédérique Peschaud, Michel Prudhomme, Jean-Pierre Triboulet, Christophe Mariette

Identification of area-level influences on regions of high cancer incidence in Queensland, Australia: a classification tree approach

Open Access
Research article

Susanna M Cramb, Kerrie L Mengersen, Peter D Baade

Distinct distribution and prognostic significance of molecular subtypes of breast cancer in Chinese women: a population-based cohort study

Open Access
Research article

Yinghao Su, Ying Zheng, Wei Zheng, Kai Gu, Zhi Chen, Guoliang Li, Qiuyin Cai, Wei Lu, Xiao Ou Shu

Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer

Open Access
Research article

Nelma Pértega-Gomes, José R Vizcaíno, Vera Miranda-Gonçalves, Céline Pinheiro, Joana Silva, Helena Pereira, Pedro Monteiro, Rui M Henrique, Rui M Reis, Carlos Lopes, Fátima Baltazar

The role of a new CD44st in increasing the invasion capability of the human breast cancer cell line MCF-7

Open Access
Research article

Xin Jian Fang, Hua Jiang, Xv Peng Zhao, Wei Mei Jiang

Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model

Open Access
Research article

Virginie Follin-Arbelet, Peter O Hofgaard, Harald Hauglin, Soheil Naderi, Anders Sundan, Rune Blomhoff, Bjarne Bogen, Heidi K Blomhoff

Safety and pharmacokinetics of motesanib in combination with gemcitabine and erlotinib for the treatment of solid tumors: a phase 1b study

Open Access
Research article

Dusan Kotasek, Niall Tebbutt, Jayesh Desai, Stephen Welch, Lillian L Siu, Sheryl McCoy, Yu-Nien Sun, Jessica Johnson, Adeboye H Adewoye, Timothy Price

Heparin based prophylaxis to prevent venous thromboembolic events and death in patients with cancer - a subgroup analysis of CERTIFY

Open Access
Research article

Sylvia Haas, Sebastian M Schellong, Ulrich Tebbe, Horst-Eberhard Gerlach, Rupert Bauersachs, Nima Melzer, Claudia Abletshauser, Christian Sieder, Peter Bramlage, Hanno Riess

Living with prostate cancer: randomised controlled trial of a multimodal supportive care intervention for men with prostate cancer

Open Access
Study protocol

Suzanne K Chambers, Robert U Newton, Afaf Girgis, Lisa Nielsen, Stephen Lepore, Cathrine Mihalopoulos, RA Gardiner, Daniel A Galvão, Stefano Occhipinti

Pilot study on developing a decision support tool for guiding re-administration of chemotherapeutic agent after a serious adverse drug reaction

Open Access
Research article

Pei Yi Loke, Lita Chew, Chun Wei Yap

CD133: a potential indicator for differentiation and prognosis of human cholangiocarcinoma

Open Access
Research article

Linni Fan, Furong He, Hongxiang Liu, Jin Zhu, Yixiong Liu, Zhiyong Yin, Lu Wang, Ying Guo, Zhe Wang, Qingguo Yan, Gaosheng Huang

Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL)

Open Access
Research article

Seok Jin Kim, Chul Won Choi, Yeung-Chul Mun, Sung Yong Oh, Hye Jin Kang, Soon Il Lee, Jong Ho Won, Min Kyoung Kim, Jung Hye Kwon, Jin Seok Kim, Jae-Yong Kwak, Jung Mi Kwon, In Gyu Hwang, Hyo Jung Kim, Jae Hoon Lee, Sukjoong Oh, Keon Woo Park, Cheolwon Suh, Won Seog Kim

5-allyl-7-gen-difluoromethoxychrysin enhances TRAIL-induced apoptosis in human lung carcinoma A549 cells

Open Access
Research article

Zhao-Hui Xie, Mei-Fang Quan, Fei Liu, Jian-Guo Cao, Jian-Song Zhang

Primary leiomyosarcoma of the seminal vesicle: Case report and review of the literature

Open Access
Case report

Cécile Cauvin, Laurence Moureau-Zabotto, Bruno Chetaille, Werner Hilgers, Yves Denoux, Jocelyne Jacquemier, Jérôme Guiramand, Anthony Sarran, François Bertucci

NMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene

Open Access
Research article

Henna Mattila, Martin Schindler, Jarkko Isotalo, Tarja Ikonen, Mauno Vihinen, Hannu Oja, Teuvo LJ Tammela, Tiina Wahlfors, Johanna Schleutker

Role of serum S100B and PET-CT in follow-up of patients with cutaneous melanoma

Open Access
Research article

Barbara Peric, Ivana Zagar, Srdjan Novakovic, Janez Zgajnar, Marko Hocevar

A comparison of breast density measures between mothers and adolescent daughters

Open Access
Research article

Gertraud Maskarinec, Yukiko Morimoto, Yihe Daida, John Shepherd, Rachel Novotny

Diagnostic value of circulating tumor cell detection in bladder and urothelial cancer: systematic review and meta-analysis

Open Access
Research article

Pavlos Msaouel, Michael Koutsilieris

The CpG island methylator phenotype may confer a survival benefit in patients with stage II or III colorectal carcinomas receiving fluoropyrimidine-based adjuvant chemotherapy

Open Access
Research article

Byung-Hoon Min, Jeong Mo Bae, Eui Jin Lee, Hong Suk Yu, Young-Ho Kim, Dong Kyung Chang, Hee Cheol Kim, Cheol Keun Park, Suk-Hee Lee, Kyoung-Mee Kim, Gyeong Hoon Kang

Demographic variation in incidence of adult glioma by subtype, United States, 1992-2007

Open Access
Research article

Robert Dubrow, Amy S Darefsky

Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas

Open Access
Research article

Vilde D Haakensen, Trine Bjøro, Torben Lüders, Margit Riis, Ida K Bukholm, Vessela N Kristensen, Melissa A Troester, Marit M Homen, Giske Ursin, Anne-Lise Børresen-Dale, Åslaug Helland

Ki67 proliferation in core biopsies versus surgical samples - a model for neo-adjuvant breast cancer studies

Open Access
Research article

Quinci Romero, Pär-Ola Bendahl, Marie Klintman, Niklas Loman, Christian Ingvar, Lisa Rydén, Carsten Rose, Dorthe Grabau, Signe Borgquist

Repression of human activation induced cytidine deaminase by miR-93 and miR-155

Open Access
Research article

Glen M Borchert, Nathaniel W Holton, Erik D Larson

Fatty acid binding proteins (FABPs) in prostate, bladder and kidney cancer cell lines and the use of IL-FABP as survival predictor in patients with renal cell carcinoma

Open Access
Research article

Angelika Tölle, Saba Suhail, Monika Jung, Klaus Jung, Carsten Stephan

Versican but not decorin accumulation is related to malignancy in mammographically detected high density and malignant-appearing microcalcifications in non-palpable breast carcinomas

Open Access
Research article

Spyros S Skandalis, Vassiliki T Labropoulou, Panagiota Ravazoula, Eleni Likaki-Karatza, Katalin Dobra, Haralabos P Kalofonos, Nikos K Karamanos, Achilleas D Theocharis

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

Open Access
Research article

Gabriele D Maurer, Daniel P Brucker, Oliver Bähr, Patrick N Harter, Elke Hattingen, Stefan Walenta, Wolfgang Mueller-Klieser, Joachim P Steinbach, Johannes Rieger

Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice

Open Access
Research article

Lunyin Yu, Charles A Hales

Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type

Open Access
Research article

Bernard Krust, Diala El Khoury, Isabelle Nondier, Calaiselvy Soundaramourty, Ara G Hovanessian

Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells

Open Access
Research article

Ju-Hee Kang, Ki-Hoon Song, Kyung-Chae Jeong, Sunshin Kim, Changsun Choi, Chang Hoon Lee, Seung Hyun Oh

Matched-pair analysis of patients with female and male breast cancer: a comparative analysis

Open Access
Research article

Robert Foerster, Frank G Foerster, Volkhard Wulff, Birgit Schubotz, Dieter Baaske, Matthias Wolfgarten, Walther C Kuhn, Christian Rudlowski

Prognostic significance of CD44s expression in resected non-small cell lung cancer

Open Access
Research article

Yoon Ho Ko, Hye Sung Won, Eun Kyoung Jeon, Sook Hee Hong, Sang Young Roh, Young Seon Hong, Jae Ho Byun, Chan-Kwon Jung, Jin Hyoung Kang

Metabolic alteration of urinary steroids in pre- and post-menopausal women, and men with papillary thyroid carcinoma

Open Access
Research article

Man Ho Choi, Ju-Yeon Moon, Sung-Hee Cho, Bong Chul Chung, Eun Jig Lee

Malignant melanoma arising from a perianal fistula and harbouring a BRAFgene mutation: a case report

Open Access
Case report

Conrado Martinez-Cadenas, Nuria Bosch, Lucas Peñas, Esther Flores-Couce, Enrique Ochoa, Javier Munárriz, Juan P Aracil, Marcos Tajahuerce, Ramón Royo, Rafael Lozoya, Enrique Boldó

Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients

Open Access
Research article

Johannes Stratmann, Chao-Jie Wang, Sebastian Gnosa, Åsa Wallin, David Hinselwood, Xiao-Feng Sun, Hong Zhang

Rationale and design of DECISION: a double-blind, randomized, placebo-controlled phase III trial evaluating the efficacy and safety of sorafenib in patients with locally advanced or metastatic radioactive iodine (RAI)-refractory, differentiated thyroid cancer

Open Access
Study protocol

Marcia S Brose, Christopher M Nutting, Steven I Sherman, Young Kee Shong, Johannes WA Smit, Gerhard Reike, John Chung, Joachim Kalmus, Christian Kappeler, Martin Schlumberger

Rationale and design of the Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research Trial (MANTICORE 101 - Breast): a randomized, placebo-controlled trial to determine if conventional heart failure pharmacotherapy can prevent trastuzumab-mediated left ventricular remodeling among patients with HER2+ early breast cancer using cardiac MRI

Open Access
Study protocol

Edith Pituskin, Mark Haykowsky, John R Mackey, Richard B Thompson, Justin Ezekowitz, Sheri Koshman, Gavin Oudit, Kelvin Chow, Joseph J Pagano, Ian Paterson

Smoking and drinking in relation to oral potentially malignant disorders in Puerto Rico: a case-control study

Open Access
Research article

Lin Li, Walter J Psoter, Carmen J Buxó, Augusto Elias, Lumarie Cuadrado, Douglas E Morse

MMP-1 expression has an independent prognostic value in breast cancer

Open Access
Research article

Pia Boström, Mirva Söderström, Tero Vahlberg, Karl-Ove Söderström, Peter J Roberts, Olli Carpén, Pirkko Hirsimäki

Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1Cin pancreatic endocrine tumors

Open Access
Research article

Giorgio Malpeli, Eliana Amato, Mario Dandrea, Caterina Fumagalli, Valentina Debattisti, Letizia Boninsegna, Giuseppe Pelosi, Massimo Falconi, Aldo Scarpa

Unicentric castleman's disease located in the lower extremity: a case report

Open Access
Case report

Inga-Marie Schaefer, Harald Günnel, Stefan Schweyer, Michael Korenkov

Quality of life assessment as a predictor of survival in non-small cell lung cancer

Open Access
Research article

Donald P Braun, Digant Gupta, Edgar D Staren

Childhood acute leukemias are frequent in Mexico City: descriptive epidemiology

Open Access
Research article

María Luisa Pérez-Saldivar, Arturo Fajardo-Gutiérrez, Roberto Bernáldez-Ríos, Armando Martínez-Avalos, Aurora Medina-Sanson, Laura Espinosa-Hernández, José de Diego Flores-Chapa, Raquel Amador-Sánchez, José Gabriel Peñaloza-González, Francisco Javier Álvarez-Rodríguez, Victoria Bolea-Murga, Janet Flores-Lujano, María del Carmen Rodríguez-Zepeda, Roberto Rivera-Luna, Elisa María Dorantes-Acosta, Elva Jiménez-Hernández, Martha Alvarado-Ibarra, Martha Margarita Velázquez-Aviña, José Refugio Torres-Nava, David Aldebarán Duarte-Rodríguez, Rogelio Paredes-Aguilera, María de los Ángeles del Campo-Martínez, Rocío Cárdenas-Cardos, Paola Hillary Alamilla-Galicia, Vilma Carolina Bekker-Méndez, Manuel Carlos Ortega-Alvarez, Juan Manuel Mejia-Arangure

A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells

Open Access
Research article

Megumi Kawamoto, Tomohisa Horibe, Masayuki Kohno, Koji Kawakami

Factors determining the survival of nasopharyngeal carcinoma with lung metastasis alone: does combined modality treatment benefit?

Open Access
Research article

Xun Cao, Li-Ru He, Fang-Yun Xie, You-Fang Chen, Zhe-Sheng Wen

Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

Open Access
Research article

Sudhakar Chintharlapalli, Sabitha Papineni, Ping Lei, Satya Pathi, Stephen Safe

Molecular targeting of prostate cancer cells by a triple drug combination down-regulates integrin driven adhesion processes, delays cell cycle progression and interferes with the cdk-cyclin axis

Open Access
Research article

Steffen Wedel, Lukasz Hudak, Jens-Michael Seibel, Jasmina Makarević, Eva Juengel, Igor Tsaur, Ana Waaga-Gasser, Axel Haferkamp, Roman A Blaheta

A Cross-Species Analysis of a Mouse Model of Breast Cancer-Specific Osteolysis and Human Bone Metastases Using Gene Expression Profiling

Open Access
Research article

Anguraj Sadanandam, Mitsuru Futakuchi, Costas A Lyssiotis, William J Gibb, Rakesh K Singh

Twist and snai1 expression in pharyngeal squamous cell carcinoma stroma is related to cancer progression

Open Access
Research article

Anna Jouppila-Mättö, Mervi Närkiö-Mäkelä, Ylermi Soini, Matti Pukkila, Reijo Sironen, Hanna Tuhkanen, Arto Mannermaa, Veli-Matti Kosma

Accuracy of perfusion MRI with high spatial but low temporal resolution to assess invasive breast cancer response to neoadjuvant chemotherapy: a retrospective study

Open Access
Research article

Cédric de Bazelaire, Raphael Calmon, Isabelle Thomassin, Clément Brunon, Anne-Sophie Hamy, Laure Fournier, Daniel Balvay, Marc Espié, Nathalie Siauve, Olivier Clément, Eric de Kerviler, Charles-André Cuénod

A randomized, phase III trial of capecitabine plus bevacizumab (Cape-Bev) versus capecitabine plus irinotecan plus bevacizumab (CAPIRI-Bev) in first-line treatment of metastatic colorectal cancer: The AIO KRK 0110 Trial/ML22011 Trial

Open Access
Study protocol

Clemens Giessen, Ludwig Fischer von Weikersthal, Axel Hinke, Sebastian Stintzing, Frank Kullmann, Ursula Vehling-Kaiser, Julia Mayerle, Markus Bangerter, Claudio Denzlinger, Markus Sieber, Christian Teschendorf, Jens Freiberg-Richter, Christoph Schulz, Dominik Paul Modest, Nicolas Moosmann, Philipp Aubele, Volker Heinemann

Progressive Resistance Training and Cancer Testis (PROTRACT) - Efficacy of resistance training on muscle function, morphology and inflammatory profile in testicular cancer patients undergoing chemotherapy: design of a randomized controlled trial

Open Access
Study protocol

Jesper F Christensen, Jesper L Andersen, Lis Adamsen, Birgitte Lindegaard, Abigail L Mackey, Rie H Nielsen, Mikael Rørth, Gedske Daugaard

Neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy for patients with resectable gastric cancer (CRITICS)

Open Access
Study protocol

Johan L Dikken, Johanna W van Sandick, HA Maurits Swellengrebel, Pehr A Lind, Hein Putter, Edwin PM Jansen, Henk Boot, Nicole CT van Grieken, Cornelis JH van de Velde, Marcel Verheij, Annemieke Cats

Kinetic Targeting of pegylated liposomal Doxorubicin: a new Approach to Reduce Toxicity during Chemotherapy (CARL-trial)

Open Access
Research article

Jürgen Eckes, Oliver Schmah, Jan W Siebers, Ursula Groh, Stefan Zschiedrich, Beate Rautenberg, Annette Hasenburg, Martin Jansen, Martin J Hug, Karl Winkler, Gerhard Pütz

Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

Open Access
Research article

Anna Abulí, Ceres Fernández-Rozadilla, Virginia Alonso-Espinaco, Jenifer Muñoz, Victoria Gonzalo, Xavier Bessa, Dolors González, Joan Clofent, Joaquin Cubiella, Juan D Morillas, Joaquim Rigau, Mercedes Latorre, Fernando Fernández-Bañares, Elena Peña, Sabino Riestra, Artemio Payá, Rodrigo Jover, Rosa M Xicola, Xavier Llor, Luis Carvajal-Carmona, Cristina M Villanueva, Victor Moreno, Josep M Piqué, Angel Carracedo, Antoni Castells, Montserrat Andreu, Clara Ruiz-Ponte, Sergi Castellví-Bel

Adjuvant gemcitabine versus NEOadjuvant gemcitabine/oxaliplatin plus adjuvant gemcitabine in resectable pancreatic cancer: a randomized multicenter phase III study (NEOPAC study)

Open Access
Study protocol

Stefan Heinrich, Bernhard Pestalozzi, Mickael Lesurtel, Frederik Berrevoet, Stéphanie Laurent, Jean-Robert Delpero, Jean-Luc Raoul, Phillippe Bachellier, Patrick Dufour, Markus Moehler, Achim Weber, Hauke Lang, Xavier Rogiers, Pierre-Alain Clavien

Early dissemination of bevacizumab for advanced colorectal cancer: a prospective cohort study

Open Access
Research article

S Yousuf Zafar, Jennifer L Malin, Steven C Grambow, David H Abbott, Deborah Schrag, Jane T Kolimaga, Leah L Zullig, Jane C Weeks, Mona N Fouad, John Z Ayanian, Robert Wallace, Katherine L Kahn, Patricia A Ganz, Paul Catalano, Dee W West, Dawn Provenzale

Downregulation of TFPI in breast cancer cells induces tyrosine phosphorylation signaling and increases metastatic growth by stimulating cell motility

Open Access
Research article

Benedicte Stavik, Grethe Skretting, Hans-Christian Aasheim, Mari Tinholt, Lillian Zernichow, Marit Sletten, Per Morten Sandset, Nina Iversen

Cytotoxicity of VEGF121/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2

Open Access
Research article

Khalid A Mohamedali, Sophia Ran, Candelaria Gomez-Manzano, Latha Ramdas, Jing Xu, Sehoon Kim, Lawrence H Cheung, Walter N Hittelman, Wei Zhang, Johannes Waltenberger, Philip E Thorpe, Michael G Rosenblum

Protocol for MInimizing the Risk of Metachronous Adenomas of the CoLorectum with Green Tea Extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population

Open Access
Study protocol

Julia C Stingl, Thomas Ettrich, Rainer Muche, Martina Wiedom, Jürgen Brockmöller, Angela Seeringer, Thomas Seufferlein

The BH3 mimetic ABT-737 increases treatment efficiency of paclitaxel against hepatoblastoma

Open Access
Research article

Justus Lieber, Carmen Eicher, Julia Wenz, Bettina Kirchner, Steven W Warmann, Jörg Fuchs, Sorin Armeanu-Ebinger

Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy

Open Access
Research article

Juliana Schwaab, Karoline Horisberger, Philipp Ströbel, Beatrice Bohn, Deniz Gencer, Georg Kähler, Peter Kienle, Stefan Post, Frederik Wenz, Wolf-Karsten Hofmann, Ralf-Dieter Hofheinz, Philipp Erben

Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers

Open Access
Research article

Jun Shen, Ziling Liu, Nevins W Todd, Howard Zhang, Jipei Liao, Lei Yu, Maria A Guarnera, Ruiyun Li, Ling Cai, Min Zhan, Feng Jiang

The association between socio-demographic characteristics and adherence to breast and colorectal cancer screening: Analysis of large sub populations

Open Access
Research article

Rachel Wilf-Miron, Ronit Peled, Einat Yaari, Anna Vainer, Avi Porath, Ehud Kokia

EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation

Open Access
Research article

Lisa C Neumann, Andreas Weinhäusel, Stefanie Thomas, Bernhard Horsthemke, Dietmar R Lohmann, Michael Zeschnigk

Increased fracture rate in women with breast cancer: a review of the hidden risk

Open Access
Review

Jean-Jacques Body

Phase II study of weekly paclitaxel and capecitabine in patients with metastatic or recurrent esophageal squamous cell carcinoma

Open Access
Research article

Tak Yun, Ji-Youn Han, Jin Soo Lee, Hyun Lee Choi, Hyae Young Kim, Byung-Ho Nam, Heung Tae Kim

An examination of cancer-related fatigue through proposed diagnostic criteria in a sample of cancer patients in Taiwan

Open Access
Research article

En-Tien Yeh, Shu-Chuen Lau, Wei-Ju Su, Duu-Jian Tsai, Ying-Yueh Tu, Yuen-Liang Lai

Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3

Open Access
Research article

Nicolas Porquet, Andrée Poirier, François Houle, Anne-Laure Pin, Stéphanie Gout, Pierre-Luc Tremblay, Éric R Paquet, Roscoe Klinck, François A Auger, Jacques Huot

Quality-of-life evaluation for advanced non-small-cell lung cancer: a comparison between vinorelbine plus gemcitabine followed by docetaxel versus paclitaxel plus carboplatin regimens in a randomized trial: Japan Multinational Trial Organization LC00-03 (BRI LC03-01)

Open Access
Research article

Masaaki Kawahara, Harue Tada, Akihiro Tokoro, Satoshi Teramukai, Hideki Origasa, Kaoru Kubota, Tetsu Shinkai, Masanori Fukushima, Kiyoyuki Furuse

A Nation-Wide multicenter 10-year (1999-2008) retrospective clinical epidemiological study of female breast cancer in china

Open Access
Research article

Jing Li, Bao-Ning Zhang, Jin-Hu Fan, Yi Pang, Pin Zhang, Shu-Lian Wang, Shan Zheng, Bin Zhang, Hong-Jian Yang, Xiao-Ming Xie, Zhong-Hua Tang, Hui Li, Jia-Yuan Li, Jian-Jun He, You-Lin Qiao

Single-agent pegylated liposomal doxorubicin (PLD) in the treatment of metastatic breast cancer: results of an Austrian observational trial

Open Access
Research article

Michael Fiegl, Brigitte Mlineritsch, Michael Hubalek, Rupert Bartsch, Ursula Pluschnig, Günther G Steger

Oxidative stress and antioxidant status in primary bone and soft tissue sarcoma

Open Access
Research article

Fatima M Nathan, Vivek A Singh, Amreeta Dhanoa, Uma D Palanisamy

A novel inhibitor of hypoxia-inducible factor-1α P3155 also modulates PI3K pathway and inhibits growth of prostate cancer cells

Open Access
Research article

Sonal M Manohar, Amol A Padgaonkar, Archana Jalota-Badhwar, Vinay Sonawane, Maggie J Rathos, Sanjay Kumar, Kalpana S Joshi

Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer

Open Access
Research article

Lopamudra Das Roy, Sriparna Ghosh, Latha B Pathangey, Teresa L Tinder, Helen E Gruber, Pinku Mukherjee

Clinical management of gastric cancer: results of a multicentre survey

Open Access
Research article

Xiaolong Zhang, Nanjing Li, Wen Wei, Wenxiu Yao, Ke Xie, Jiankun Hu, Lida Shen, Weizheng Ji, You Lu, Feng Wen, Yu Jiang, Feng Xu, Hong Feng, Feng Bi, Qiu Li

Antioxidants and breast cancer risk- a population-based case-control study in Canada

Open Access
Research article

Sai Yi Pan, Jia Zhou, Laurie Gibbons, Howard Morrison, Shi Wu Wen

Standard versus prosocial online support groups for distressed breast cancer survivors: a randomized controlled trial

Open Access
Study protocol

Stephen J Lepore, Joanne S Buzaglo, Morton A Lieberman, Mitch Golant, Adam Davey

Sentinel lymph node biopsy is unsuitable for routine practice in younger female patients with unilateral low-risk papillary thyroid carcinoma

Open Access
Research article

Ou Huang, WeiLi Wu, OuChen Wang, Jie You, Quan Li, DuPing Huang, XiaoQu Hu, JinMiao Qu, Cun Jin, YouQun Xiang, Kai Yang, ShuMei Zhou, XueMin Chen, YiFei Pan, GuiLong Guo, XiaoHua Zhang

Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways

Open Access
Research article

Anja C Pickhard, Johanna Margraf, Andreas Knopf, Thomas Stark, Guido Piontek, Carolin Beck, Anne-Laure Boulesteix, Elias Q Scherer, Steffi Pigorsch, Jürgen Schlegel, Wolfgang Arnold, Rudolf Reiter

Overexpression of carbonic anhydrase and HIF-1α in Wilms tumours

Open Access
Research article

Josiah V Dungwa, Linda P Hunt, Pramila Ramani

The hOGG1 Ser326Cys polymorphism and prostate cancer risk: a meta-analysis of 2584 cases and 3234 controls

Open Access
Research article

Hongtuan Zhang, Yong Xu, Zhihong Zhang, Liang Li

Overexpression of members of the microRNA-183 family is a risk factor for lung cancer: A case control study

Open Access
Research article

Wangyu Zhu, XiaoGuang Liu, JianYing He, DongDong Chen, YanYan Hunag, Yong Kui Zhang

Younger age as a prognostic indicator in breast cancer: A cohort study

Open Access
Research article

Elrasheid AH Kheirelseid, Jennifer ME Boggs, Catherine Curran, Ronan W Glynn, Cara Dooley, Karl J Sweeney, Michael J Kerin

Aberrant upregulation of 14-3-3ơ expression serves as an inferior prognostic biomarker for gastric cancer

Open Access
Research article

Wei-hua Zhou, Fang Tang, Jie Xu, Xing Wu, Zhi-ying Feng, Hai-gang Li, Dong-jun Lin, Chun-kui Shao, Quentin Liu

Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B

Open Access
Research article

Chau-Ting Yeh, Tiffany Chen, Chao-Wei Hsu, Yi-Cheng Chen, Ming-Wei Lai, Kung-Hao Liang, Tse-Ching Chen

Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer

Open Access
Research article

Xi Xia, Quanfu Ma, Xiao Li, Teng Ji, Pingbo Chen, Hongbin Xu, Kezhen Li, Yong Fang, Danhui Weng, Yanjie Weng, Shujie Liao, Zhiqiang Han, Ronghua Liu, Tao Zhu, Shixuan Wang, Gang Xu, Li Meng, Jianfeng Zhou, Ding Ma

Assessing awareness of colorectal cancer symptoms: Measure development and results from a population survey in the UK

Open Access
Research article

Emily Power, Alice Simon, Dorota Juszczyk, Sara Hiom, Jane Wardle

Purine Nucleoside Phosphorylase mediated molecular chemotherapy and conventional chemotherapy: A tangible union against chemoresistant cancer

Open Access
Research article

Preetinder P Singh, Swapna Joshi, Pamela J Russell, Sham Nair, Aparajita Khatri

ICOS gene polymorphisms are associated with sporadic breast cancer: a case-control study

Open Access
Research article

Fengyan Xu, Dalin Li, Qiujin Zhang, Zhenkun Fu, Jie Zhang, Weiguang Yuan, Shuang Chen, Da Pang, Dianjun Li

Brain metastases from breast cancer: prognostic significance of HER-2 overexpression, effect of trastuzumab and cause of death

Open Access
Research article

Romuald Le Scodan, Ludivine Jouanneau, Christophe Massard, Maya Gutierrez, Youlia Kirova, Pascal Cherel, Julie Gachet, Alain Labib, Emmanuelle Mouret-Fourme

An ecological analysis of colorectal cancer incidence and mortality: Differences by sexual orientation

Open Access
Research article

Ulrike Boehmer, Al Ozonoff, Xiaopeng Miao

An investigation of the apparent breast cancer epidemic in France: screening and incidence trends in birth cohorts

Open Access
Research article

Bernard Junod, Per-Henrik Zahl, Robert M Kaplan, Jørn Olsen, Sander Greenland

Unstaged cancer in the United States: a population-based study

Open Access
Research article

Ray M Merrill, Arielle Sloan, Allison E Anderson, Karem Ryker

The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation

Open Access
Research article

Sandra Sernbo, Elin Gustavsson, Donal J Brennan, William M Gallagher, Elton Rexhepaj, Frida Rydnert, Karin Jirström, Carl AK Borrebaeck, Sara Ek

Clinical characteristics and prognosis of osteosarcoma in young children: a retrospective series of 15 cases

Open Access
Research article

Maud AM Guillon, Pierre MJ Mary, Laurence Brugière, Perrine Marec-Bérard, Hélène D Pacquement, Claudine Schmitt, Jean-Marc Guinebretière, Marie-Dominique P Tabone

A moderate elevation of circulating levels of IGF-I does not alter ErbB2 induced mammary tumorigenesis

Open Access
Research article

Robert K Dearth, Isere Kuiatse, Yu-Fen Wang, Lan Liao, Susan G Hilsenbeck, Powel H Brown, Jianming Xu, Adrian V Lee

Snail1 induces epithelial-to-mesenchymal transition and tumor initiating stem cell characteristics

Open Access
Research article

Hien Dang, Wei Ding, Dow Emerson, C Bart Rountree

P53 suppresses expression of the 14-3-3gamma oncogene

Open Access
Research article

Vijayababu M Radhakrishnan, Charles W Putnam, Wenqing Qi, Jesse D Martinez

Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study

Open Access
Research article

Annemieke WJ Opstal-van Winden, Esmeralda JM Krop, Monica H Kåredal, Marie-Christine W Gast, Christian H Lindh, Marina C Jeppsson, Bo AG Jönsson, Diederick E Grobbee, Petra HM Peeters, Jos H Beijnen, Carla H van Gils, Roel CH Vermeulen

Safety, feasibility and effects of an individualised walking intervention for women undergoing chemotherapy for ovarian cancer: a pilot study

Open Access
Research article

Melissa J Newton, Sandi C Hayes, Monika Janda, Penelope M Webb, Andreas Obermair, Elizabeth G Eakin, David Wyld, Louisa G Gordon, Vanessa L Beesley

Tracking human multiple myeloma xenografts in NOD-Rag-1/IL-2 receptor gamma chain-null mice with the novel biomarker AKAP-4

Open Access
Research article

Leonardo Mirandola, Yuefei Yu, Marjorie R Jenkins, Raffaella Chiaramonte, Everardo Cobos, Constance M John, Maurizio Chiriva-Internati

Knowledge and attitudes of primary healthcare patients regarding population-based screening for colorectal cancer

Open Access
Research article

Maria Ramos, Maria Llagostera, Magdalena Esteva, Elena Cabeza, Xavier Cantero, Manel Segarra, Maria Martín-Rabadán, Guillem Artigues, Maties Torrent, Joana Maria Taltavull, Joana Maria Vanrell, Mercè Marzo, Joan Llobera

The extramural metastasis might be categorized in lymph node staging for colorectal cancer

Open Access
Research article

Hai-Bo Qiu, Gong Chen, Rajiv P Keshari, Hui-Yan Luo, Wang Fang, Miao-Zhen Qiu, Zhi-Wei Zhou, Rui-Hua Xu

An overview of cancer/testis antigens expression in classical Hodgkin's lymphoma (cHL) identifies MAGE-A family and MAGE-C1 as the most frequently expressed antigens in a set of Brazilian cHL patients

Open Access
Research article

Riguel J Inaoka, Achim A Jungbluth, Otávio CG Baiocchi, Mariane CG Assis, Nicole C Hanson, Denise Frosina, Jodie Tassello, Adriana B Bortoluzzo, Antonio C Alves, Gisele WB Colleoni

Semiallogenic fusions of MSI+tumor cells and activated B cells induce MSI-specific T cell responses

Open Access
Research article

Yvette Garbe, Ulrike Klier, Michael Linnebacher

Clinical pharmacogenomic testing of KRAS, BRAF and EGFRmutations by high resolution melting analysis and ultra-deep pyrosequencing

Open Access
Research article

Emma Borràs, Ismael Jurado, Imma Hernan, María José Gamundi, Miguel Dias, Isabel Martí, Begoña Mañé, Àngels Arcusa, José AG Agúndez, Miguel Blanca, Miguel Carballo

Cyclin D1, Id1 and EMT in breast cancer

Open Access
Research article

Nicholas P Tobin, Andrew H Sims, Katja L Lundgren, Sophie Lehn, Göran Landberg

A randomized controlled trial to investigate the influence of low dose radiotherapy on immune stimulatory effects in liver metastases of colorectal cancer

Open Access
Study protocol

Christoph Reissfelder, Carmen Timke, Hubertus Schmitz-Winnenthal, Nuh N Rahbari, Moritz Koch, Felix Klug, Falk Roeder, Lutz Edler, Jürgen Debus, Markus W Büchler, Philipp Beckhove, Peter E Huber, Jürgen Weitz

A multilevel investigation of inequalities in clinical and psychosocial outcomes for women after breast cancer

Open Access
Study protocol

Philippa H Youl, Peter D Baade, Joanne F Aitken, Suzanne K Chambers, Gavin Turrell, Christopher Pyke, Jeffrey Dunn

Prognostic and predictive value of clinical and biochemical factors in breast cancer patients with bone metastases receiving "metronomic" zoledronic acid

Open Access
Research article

Xinmin Zhao, Xiaofeng Xu, Qunling Zhang, Zhen Jia, Si Sun, Jian Zhang, Biyun Wang, Zhonghua Wang, Xichun Hu

Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells

Open Access
Research article

Kristin M Müller, Ingun H Tveteraas, Monica Aasrum, John Ødegård, Mona Dawood, Olav Dajani, Thoralf Christoffersen, Dagny L Sandnes

Defining the optimal dose of radiation in leukemic patients with extramedullary lesions

Open Access
Research article

Jin Ho Song, Seok Hyun Son, Ju Hwan Lee, Su Mi Chung, Hong Seok Jang, Byung Ock Choi

Exposure to statins and risk of common cancers: a series of nested case-control studies

Open Access
Research article

Yana Vinogradova, Carol Coupland, Julia Hippisley-Cox

CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers

Open Access
Research article

Eleonor Olsson, Gabriella Honeth, Pär-Ola Bendahl, Lao H Saal, Sofia Gruvberger-Saal, Markus Ringnér, Johan Vallon-Christersson, Göran Jönsson, Karolina Holm, Kristina Lövgren, Mårten Fernö, Dorthe Grabau, Åke Borg, Cecilia Hegardt

Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma

Open Access
Research article

Song Wu, Yong Wang, Liang Sun, Zhiling Zhang, Zhimao Jiang, Zike Qin, Hui Han, Zhuowei Liu, Xianxin Li, Aifa Tang, Yaoting Gui, Zhiming Cai, Fangjian Zhou

The time since last menstrual period is important as a clinical predictor for non-steroidal aromatase inhibitor-related arthralgia

Open Access
Research article

Miyuki Kanematsu, Masami Morimoto, Junko Honda, Taeko Nagao, Misako Nakagawa, Masako Takahashi, Akira Tangoku, Mitsunori Sasa

A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence

Open Access
Research article

Patricia P Reis, Levi Waldron, Bayardo Perez-Ordonez, Melania Pintilie, Natalie Naranjo Galloni, Yali Xuan, Nilva K Cervigne, Giles C Warner, Antti A Makitie, Colleen Simpson, David Goldstein, Dale Brown, Ralph Gilbert, Patrick Gullane, Jonathan Irish, Igor Jurisica, Suzanne Kamel-Reid

Intraoperative radiotherapy electron boost in advanced and recurrent epithelial ovarian carcinoma: a retrospective study

Open Access
Research article

Ying Gao, Zi Liu, Xi Chen, Wei Luo, Long Zhang, Juan Wang

Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo

Open Access
Research article

Mélissa Labelle-Côté, Julie Dusseault, Salma Ismaïl, Aude Picard-Cloutier, Peter M Siegel, Louise Larose

Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT

Open Access
Research article

Enke Baldini, Yannick Arlot-Bonnemains, Salvatore Sorrenti, Caterina Mian, Maria R Pelizzo, Enrico De Antoni, Silvio Palermo, Stefania Morrone, Susi Barollo, Angela Nesca, Costanzo G Moretti, Massimino D'Armiento, Salvatore Ulisse

Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review

Open Access
Case report

Simon G Launay, Bruno Chetaille, Fanny Medina, Delphine Perrot, Serge Nazarian, Jérôme Guiramand, Laurence Moureau-Zabotto, François Bertucci

Early mortality and overall survival in oncology phase I trial participants: can we improve patient selection?

Open Access
Research article

Nicole G Chau, Ana Florescu, Kelvin K Chan, Lisa Wang, Eric X Chen, Philippe Bedard, Amit M Oza, Lillian L Siu

Serum levels of selenium and smoking habits at age 50 influence long term prostate cancer risk; a 34 year ULSAM follow-up

Open Access
Research article

Birgitta Grundmark, Björn Zethelius, Hans Garmo, Lars Holmberg

Activating mutation in MET oncogene in familial colorectal cancer

Open Access
Research article

Deborah W Neklason, Michelle W Done, Nykole R Sargent, Ann G Schwartz, Hoda Anton-Culver, Constance A Griffin, Dennis J Ahnen, Joellen M Schildkraut, Gail E Tomlinson, Louise C Strong, Alexander R Miller, Jill E Stopfer, Randall W Burt

Double sampling of a faecal immunochemical test is not superior to single sampling for detection of colorectal neoplasia: a colonoscopy controlled prospective cohort study

Open Access
Research article

Frank A Oort, Sietze T van Turenhout, Veerle MH Coupé, René WM van der Hulst, Eric IC Wesdorp, Jochim S Terhaar sive Droste, Ilhame Ben Larbi, Shannon L Kanis, Edwin van Hengel, Anneke A Bouman, Gerrit A Meijer, Chris JJ Mulder

INSPIRE: A phase III study of the BLP25 liposome vaccine (L-BLP25) in Asian patients with unresectable stage III non-small cell lung cancer

Open Access
Study protocol

Yi-Long Wu, Keunchil Park, Ross A Soo, Yan Sun, Karin Tyroller, David Wages, Guy Ely, James Chih-Hsin Yang, Tony Mok

Granulocyte colony-stimulating factors for febrile neutropenia prophylaxis following chemotherapy: systematic review and meta-analysis

Open Access
Research article

Katy L Cooper, Jason Madan, Sophie Whyte, Matt D Stevenson, Ron L Akehurst

A novel splice variant of the stem cell marker LGR5/GPR49 is correlated with the risk of tumor-related death in soft-tissue sarcoma patients

Open Access
Research article

Swetlana Rot, Helge Taubert, Matthias Bache, Thomas Greither, Peter Würl, Alexander W Eckert, Johannes Schubert, Dirk Vordermark, Matthias Kappler

HNF1α inhibition triggers epithelial-mesenchymal transition in human liver cancer cell lines

Open Access
Research article

Laura Pelletier, Sandra Rebouissou, Danijela Vignjevic, Paulette Bioulac-Sage, Jessica Zucman-Rossi

A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells

Open Access
Research article

Asher Castiel, Leonid Visochek, Leonid Mittelman, Françoise Dantzer, Shai Izraeli, Malka Cohen-Armon

A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients

Open Access
Research article

Mark J McKeage, Yongchuan Gu, William R Wilson, Andrew Hill, Karen Amies, Teresa J Melink, Michael B Jameson

Gene expression profile of circulating tumor cells in breast cancer by RT-qPCR

Open Access
Research article

Areti Strati, Athina Markou, Cleo Parisi, Eleni Politaki, Dimitris Mavroudis, Vasilis Georgoulias, Evi Lianidou

Drug sensitivity patterns of HHV8 carrying body cavity lymphoma cell lines

Open Access
Research article

Rita Ötvös, Henriette Skribek, Lorand L Kis, Annunziata Gloghini, Laszlo Markasz, Emilie Flaberg, Staffan Eksborg, Jozsef Konya, Lajos Gergely, Antonino Carbone, Laszlo Szekely

Early metabolic response using FDG PET/CT and molecular phenotypes of breast cancer treated with neoadjuvant chemotherapy

Open Access
Research article

Bhumsuk Keam, Seock-Ah Im, Youngil Koh, Sae-Won Han, Do-Youn Oh, Nariya Cho, Jee Hyun Kim, Wonshik Han, Keon Wook Kang, Woo Kyung Moon, Tae-You Kim, In Ae Park, Dong-Young Noh, June-Key Chung, Yung-Jue Bang

The PACOVAR-trial: A phase I/II study of pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant recurrent, pre-treated ovarian cancer

Open Access
Study protocol

Michael Eichbaum, Christine Mayer, Regina Eickhoff, Esther Bischofs, Gerhard Gebauer, Tanja Fehm, Florian Lenz, Hans-Christian Fricke, Erich Solomayer, Nikos Fersis, Marcus Schmidt, Markus Wallwiener, Andreas Schneeweiss, Christof Sohn

The combination of gefitinib and RAD001 inhibits growth of HER2 overexpressing breast cancer cells and tumors irrespective of trastuzumab sensitivity

Open Access
Research article

Wieslawa H Dragowska, Sherry A Weppler, Mohammed A Qadir, Ling Yan Wong, Yannick Franssen, Jennifer HE Baker, Anita I Kapanen, Guido JJ Kierkels, Dana Masin, Andrew I Minchinton, Karen A Gelmon, Marcel B Bally

Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma

Open Access
Case report

Geir Olav Hjortland, Leonardo A Meza-Zepeda, Klaus Beiske, Anne H Ree, Siri Tveito, Hanne Hoifodt, Per J Bohler, Knut H Hole, Ola Myklebost, Oystein Fodstad, Sigbjorn Smeland, Eivind Hovig

MiR-125b promotes proliferation and migration of type II endometrial carcinoma cells through targeting TP53INP1 tumor suppressor in vitro and in vivo

Open Access
Research article

Feizhou Jiang, Te Liu, Yinyan He, Qin Yan, Xiaoyue Chen, Hui Wang, Xiaoping Wan

Protein induced by vitamin K absence or antagonist-II production is a strong predictive marker for extrahepatic metastases in early hepatocellular carcinoma: a prospective evaluation

Open Access
Research article

Hyun-Mi Bae, Jeong-Hoon Lee, Jung-Hwan Yoon, Yoon Jun Kim, Dae Seog Heo, Hyo-Suk Lee

Survival endpoints in colorectal cancer and the effect of second primary other cancer on disease free survival

Open Access
Research article

Helgi Birgisson, Ulrik Wallin, Lars Holmberg, Bengt Glimelius

DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study

Open Access
Research article

Bernd Frank, Heiko Müller, Melanie Nicole Weck, Norman Klopp, Thomas Illig, Elke Raum, Hermann Brenner

The effect of breast cancer awareness month on internet search activity - a comparison with awareness campaigns for lung and prostate cancer

Open Access
Research article

Ronan W Glynn, John C Kelly, Norma Coffey, Karl J Sweeney, Michael J Kerin

High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: a feasibility study

Open Access
Research article

Timothy E Doyle, Rachel E Factor, Christina L Ellefson, Kristina M Sorensen, Brady J Ambrose, Jeffrey B Goodrich, Vern P Hart, Scott C Jensen, Hemang Patel, Leigh A Neumayer

Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68

Open Access
Research article

Maria Libera Ascierto, Andrea Worschech, Zhiya Yu, Sharon Adams, Jennifer Reinboth, Nanhai G Chen, Zoltan Pos, Rahul Roychoudhuri, Giovanni Di Pasquale, Davide Bedognetti, Lorenzo Uccellini, Fabio Rossano, Paolo A Ascierto, David F Stroncek, Nicholas P Restifo, Ena Wang, Aladar A Szalay, Francesco M Marincola

Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation

Open Access
Research article

Angela Sedlmaier, Nicolas Wernert, Rainer Gallitzendörfer, Mekky M Abouzied, Volkmar Gieselmann, Sebastian Franken

Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese population

Open Access
Research article

Chikako Kiyohara, Takahiko Horiuchi, Koichi Takayama, Yoichi Nakanishi

An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition

Open Access
Research article

Lauren MF Merlo, Rachelle E Kosoff, Kristin L Gardiner, Carlo C Maley

SCOPE1: a randomised phase II/III multicentre clinical trial of definitive chemoradiation, with or without cetuximab, in carcinoma of the oesophagus

Open Access
Study protocol

Christopher N Hurt, Lisette S Nixon, Gareth O Griffiths, Ruby Al-Mokhtar, Simon Gollins, John N Staffurth, Ceri J Phillips, Jane M Blazeby, Tom D Crosby

A study of head and neck cancer treatment and survival among indigenous and non-indigenous people in Queensland, Australia, 1998 to 2004

Open Access
Research article

Suzanne P Moore, Adèle C Green, Gail Garvey, Michael D Coory, Patricia C Valery

Elevated urinary levels of urokinase-type plasminogen activator receptor (uPAR) in pancreatic ductal adenocarcinoma identify a clinically high-risk group

Open Access
Research article

Claudio Sorio, Andrea Mafficini, Federico Furlan, Stefano Barbi, Antonio Bonora, Giorgio Brocco, Francesco Blasi, Giorgio Talamini, Claudio Bassi, Aldo Scarpa

TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child - evidence for chimerism involving a common mutant founder haplotype: case report

Open Access
Case report

Edaise M da Silva, Maria Isabel W Achatz, Ghyslaine Martel-Planche, André L Montagnini, Magali Olivier, Patricia A Prolla, Pierre Hainaut, Fernando A Soares

Clinical implication of HLA class I expression in breast cancer

Open Access
Research article

Koichi Kaneko, Sumiya Ishigami, Yuko Kijima, Yawara Funasako, Munetsugu Hirata, Hiroshi Okumura, Hiroyuki Shinchi, Chihaya Koriyama, Shinichi Ueno, Heiji Yoshinaka, Shoji Natsugoe

Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients

Open Access
Research article

Masashi Tatsukawa, Akinobu Takaki, Hidenori Shiraha, Kazuko Koike, Yoshiaki Iwasaki, Haruhiko Kobashi, Shin-Ichi Fujioka, Kohsaku Sakaguchi, Kazuhide Yamamoto

Protocol for the OUTREACH trial: a randomised trial comparing delivery of cancer systemic therapy in three different settings - patient's home, GP surgery and hospital day unit

Open Access
Study protocol

Pippa G Corrie, Margaret Moody, Victoria Wood, Linda Bavister, Toby Prevost, Richard A Parker, Ramon Sabes-Figuera, Paul McCrone, Helen Balsdon, Karen McKinnon, Brendan O'Sullivan, Ray S Tan, Stephen IG Barclay

Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa

Open Access
Research article

Stefan Enroth, Alvaro Rada-Iglesisas, Robin Andersson, Ola Wallerman, Alkwin Wanders, Lars Påhlman, Jan Komorowski, Claes Wadelius

Protein and lipid MALDI profiles classify breast cancers according to the intrinsic subtype

Open Access
Research article

Han Sung Kang, Seok Cheol Lee, Young Seung Park, Young Eun Jeon, Jeong Hwa Lee, So-Youn Jung, In Hae Park, Seok Hoon Jang, Hye Min Park, Chong Woo Yoo, Seok Hee Park, Sang Yun Han, Kwang Pyo Kim, Young Hwan Kim, Jungsil Ro, Hark Kyun Kim

The vitamin E analog, alpha-tocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer

Open Access
Research article

Tobias Hahn, Deborah J Bradley-Dunlop, Laurence H Hurley, Daniel Von-Hoff, Stephen Gately, Disis L Mary, Hailing Lu, Manuel L Penichet, David G Besselsen, Brook B Cole, Tanisha Meeuwsen, Edwin Walker, Emmanuel T Akporiaye

High prevalence of HPV in non-cervical sites of women with abnormal cervical cytology

Open Access
Research article

Robin Crawford, Anne-Laure Grignon, Sarah Kitson, David M Winder, Siolian LR Ball, Katie Vaughan, Margaret A Stanley, Jane C Sterling, Peter KC Goon

Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells

Open Access
Research article

Aintzane Apraiz, Jolanta K Idkowiak-Baldys, María Dolores Boyano, Gorka Pérez-Yarza, Yusuf A Hannun, Aintzane Asumendi

Results of combined treatment of anaplastic thyroid carcinoma (ATC)

Open Access
Research article

Olfa Derbel, Sami Limem, Céline Ségura-Ferlay, Jean-Christophe Lifante, Christian Carrie, Jean-Louis Peix, Françoise Borson-Chazot, Claire Bournaud, Jean-Pierre Droz, Christelle de la Fouchardière

TNFRSF1B +676 T>G polymorphism predicts survival of non-Small cell lung cancer patients treated with chemoradiotherapy

Open Access
Research article

Xiaoxiang Guan, Zhongxin Liao, Hongxia Ma, Ji Qian, Zhensheng Liu, Xianglin Yuan, Daniel Gomez, Ritsuko Komaki, Li-E Wang, Qingyi Wei

Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells

Open Access
Research article

David J Taylor, Christine E Parsons, Haiyong Han, Arul Jayaraman, Kaushal Rege

Canadian Optically-guided approach for Oral Lesions Surgical (COOLS) trial: study protocol for a randomized controlled trial

Open Access
Study protocol

Catherine F Poh, J Scott Durham, Penelope M Brasher, Donald W Anderson, Kenneth W Berean, Calum E MacAulay, J Jack Lee, Miriam P Rosin

Small interfering RNA targeting mcl-1 enhances proteasome inhibitor-induced apoptosis in various solid malignant tumors

Open Access
Research article

Wei Zhou, Jingzi Hu, Haimei Tang, Da Wang, Xuefeng Huang, Chao He, Hongbo Zhu

Prognostic significance of a systemic inflammatory response in patients receiving first-line palliative chemotherapy for recurred or metastatic gastric cancer

Open Access
Research article

Jun-Eul Hwang, Ha-Na Kim, Dae-Eun Kim, Hyun-Jung Choi, Sung-Hoon Jung, Hyun-Jeong Shim, Woo-Kyun Bae, Eu-Chang Hwang, Sang-Hee Cho, Ik-Joo Chung

GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines

Open Access
Research article

Kevin Morgan, Colette Meyer, Nicola Miller, Andrew H Sims, Ilgin Cagnan, Dana Faratian, David J Harrison, Robert P Millar, Simon P Langdon

The strengths and limitations of routine staging before treatment with abdominal CT in colorectal cancer

Open Access
Research article

Irene Grossmann, Joost M Klaase, Johannes KA Avenarius, Ignace HJT de Hingh, Walter JB Mastboom, Theo Wiggers

Chromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue

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Research article

Patrizio Castagnola, Davide Malacarne, Paola Scaruffi, Massimo Maffei, Alessandra Donadini, Emanuela Di Nallo, Simona Coco, Gian Paolo Tonini, Monica Pentenero, Sergio Gandolfo, Walter Giaretti

How the risk of liver cancer changes after alcohol cessation: A review and meta-analysis of the current literature

Open Access
Research article

Gawain A Heckley, Johan Jarl, Benedict O Asamoah, Ulf G-Gerdtham

Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study

Open Access
Research article

Nicolas Samartzis, Patrick Imesch, Konstantin J Dedes, Eleftherios P Samartzis, André Fedier, Daniel Fink, Rosmarie Caduff, Mathias K Fehr

Hakai reduces cell-substratum adhesion and increases epithelial cell invasion

Open Access
Research article

Teresa Rodríguez-Rigueiro, Manuel Valladares-Ayerbes, Mar Haz-Conde, Luis A Aparicio, Angélica Figueroa

Isometric muscle training of the spine musculature in patients with spinal bony metastases under radiation therapy

Open Access
Study protocol

Harald Rief, Alexandra D Jensen, Thomas Bruckner, Klaus Herfarth, Jürgen Debus

Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence

Open Access
Research article

Georgina Hernandez-Flores, Pablo C Ortiz-Lazareno, Jose Manuel Lerma-Diaz, Jorge R Dominguez-Rodriguez, Luis F Jave-Suarez, Adriana del C Aguilar-Lemarroy, Ruth de Celis-Carrillo, Susana del Toro-Arreola, Yessica C Castellanos-Esparza, Alejandro Bravo-Cuellar

Role and expression of FRS2 and FRS3 in prostate cancer

Open Access
Research article

Tania Valencia, Ajay Joseph, Naveen Kachroo, Steve Darby, Susan Meakin, Vincent J Gnanapragasam

Paraneoplastic syndrome mimicking adult-onset Still's disease caused by advanced lung cancer: a case report

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Case report

Ning Wu, Qiang Li, Chang-Xin Gu, Toqeer Ahmed, Xiao-Peng Yao

Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action

Open Access
Research article

Chandeshwari Chilampalli, Ruth Guillermo, Xiaoying Zhang, Radhey S Kaushik, Alan Young, David Zeman, Michael B Hildreth, Hesham Fahmy, Chandradhar Dwivedi

Activation of the human immune system by chemotherapeutic or targeted agents combined with the oncolytic parvovirus H-1

Open Access
Research article

Markus Moehler, Maike Sieben, Susanne Roth, Franziska Springsguth, Barbara Leuchs, Maja Zeidler, Christiane Dinsart, Jean Rommelaere, Peter R Galle

Pharmacogenetic profiling and cetuximab outcome in patients with advanced colorectal cancer

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Research article

Laetitia Dahan, Emmanuelle Norguet, Marie-Christine Etienne-Grimaldi, Jean-Louis Formento, Mohamed Gasmi, Isabelle Nanni, Jean Gaudart, Stéphane Garcia, L'Houcine Ouafik, Jean-François Seitz, Gérard Milano

A cost-effectiveness analysis of a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy

Open Access
Research article

Valesca P Retèl, Lisette van der Molen, Frans JM Hilgers, Coen RN Rasch, Annemiek AAMHJ L'Ortye, Lotte MG Steuten, Wim H van Harten

Clinicopathologic and gene expression parameters predict liver cancer prognosis

Open Access
Research article

Ke Hao, John Lamb, Chunsheng Zhang, Tao Xie, Kai Wang, Bin Zhang, Eugene Chudin, Nikki P Lee, Mao Mao, Hua Zhong, Danielle Greenawalt, Mark D Ferguson, Irene O Ng, Pak C Sham, Ronnie T Poon, Cliona Molony, Eric E Schadt, Hongyue Dai, John M Luk

Erratum to:Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas

Open Access
Erratum

Yosuke Hashimoto, Marek Skacel, Ian C Lavery, Abir L Mukherjee, Graham Casey, Josephine C Adams

Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line

Open Access
Research article

Gobind Singh, Leticia Odriozola, Hong Guan, Colin R Kennedy, Andrew M Chan

Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells

Open Access
Research article

Jeffery D Eskew, Takrima Sadikot, Pedro Morales, Alicia Duren, Irene Dunwiddie, Megan Swink, Xiaoying Zhang, Stacey Hembruff, Alison Donnelly, Roger A Rajewski, Brian SJ Blagg, Jacob R Manjarrez, Robert L Matts, Jeffrey M Holzbeierlein, George A Vielhauer

YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma

Open Access
Research article

Filomena de Nigris, Licciana Zanella, Francesco Cacciatore, Anna De Chiara, Flavio Fazioli, Gennaro Chiappetta, Gaetano Apice, Teresa Infante, Mario Monaco, Raffaele Rossiello, Gaetano De Rosa, Marco Alberghini, Claudio Napoli

Breast cancer patients with lobular cancer more commonly have a father than a mother diagnosed with cancer

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Research article

Carolina Ellberg, Håkan Olsson

STAT3 activation in monocytes accelerates liver cancer progression

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Research article

Wen-Yong Wu, Jun Li, Zheng-Sheng Wu, Chang-Le Zhang, Xiang-Ling Meng

The usefulness and feasibility of a screening instrument to identify psychosocial problems in patients receiving curative radiotherapy: a process evaluation

Open Access
Research article

Anna PBM Braeken, Gertrudis IJM Kempen, Daniëlle Eekers, Francis CJM van Gils, Ruud MA Houben, Lilian Lechner

Targeting hypoxic tumour cells to overcome metastasis

Open Access
Review

Kevin L Bennewith, Shoukat Dedhar

A phase II study evaluating neo-/adjuvant EIA chemotherapy, surgical resection and radiotherapy in high-risk soft tissue sarcoma

Open Access
Research article

Thomas Schmitt, Burkhard Lehner, Bernd Kasper, Marc Bischof, Falk Roeder, Sascha Dietrich, Antonia Dimitrakopoulou-Strauss, Ludwig G Strauss, Gunhild Mechtersheimer, Patrick Wuchter, Anthony D Ho, Gerlinde Egerer

The HOPE fixation technique - a promising alternative to common prostate cancer biobanking approaches

Open Access
Research article

Martin Braun, Roopika Menon, Pavel Nikolov, Robert Kirsten, Karen Petersen, David Schilling, Christina Schott, Sibylle Gündisch, Falko Fend, Karl-Friedrich Becker, Sven Perner

Plasma secretory phospholipase A2-IIa as a potential biomarker for lung cancer in patients with solitary pulmonary nodules

Open Access
Research article

Elena Kupert, Marshall Anderson, Yin Liu, Paul Succop, Linda Levin, Jiang Wang, Kathryn Wikenheiser-brokamp, Pingping Chen, Susan M Pinney, Trudy Macdonald, Zhongyun Dong, Sandra Starnes, Shan Lu

A randomised feasibility study of EPA and Cox-2 inhibitor (Celebrex) versus EPA, Cox-2 inhibitor (Celebrex), Resistance Training followed by ingestion of essential amino acids high in leucine in NSCLC cachectic patients - ACCeRT Study

Open Access
Study protocol

Elaine S Rogers, Roderick D MacLeod, Joanna Stewart, Stephen P Bird, Justin WL Keogh

Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO)

Open Access
Research article

Birgit Luber, Joëlle Deplazes, Gisela Keller, Axel Walch, Sandra Rauser, Martin Eichmann, Rupert Langer, Heinz Höfler, Susanna Hegewisch-Becker, Gunnar Folprecht, Ewald Wöll, Thomas Decker, Esther Endlicher, Sylvie Lorenzen, Falko Fend, Christian Peschel, Florian Lordick

Mammary tumors that become independent of the type I insulin-like growth factor receptor express elevated levels of platelet-derived growth factor receptors

Open Access
Research article

Craig I Campbell, Roger A Moorehead

Adaptation to statins restricts human tumour growth in Nude mice

Open Access
Research article

Julie Follet, Lionel Rémy, Vincent Hesry, Brigitte Simon, Danièle Gillet, Pierrick Auvray, Laurent Corcos, Catherine Le Jossic-Corcos

Fast track multi-discipline treatment (FTMDT trial) versus conventional treatment in colorectal cancer--the design of a prospective randomized controlled study

Open Access
Study protocol

Jiao-Jiao Zhou, Jun Li, Xiao-Jiang Ying, Yong-Mao Song, Rong Chen, Gang Chen, Min Yan, Ke-Feng Ding

Current views on the role of Notch signaling and the pathogenesis of human leukemia

Open Access
Review

Joanna Pancewicz, Christophe Nicot

Ten years of progress in radiation oncology

Open Access
Commentary

Dirk Vordermark

TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signaling

Open Access
Research article

Jan C Brase, Marc Johannes, Heiko Mannsperger, Maria Fälth, Jennifer Metzger, Lukasz A Kacprzyk, Tatjana Andrasiuk, Stephan Gade, Michael Meister, Hüseyin Sirma, Guido Sauter, Ronald Simon, Thorsten Schlomm, Tim Beißbarth, Ulrike Korf, Ruprecht Kuner, Holger Sültmann

Regulation of hTERT by BCR-ABL at multiple levels in K562 cells

Open Access
Research article

Juin Hsien Chai, Yong Zhang, Wei Han Tan, Wee Joo Chng, Baojie Li, Xueying Wang

The influence of cardiovascular morbidity on the prognosis in prostate cancer. Experience from a 12-year nationwide Danish population-based cohort study

Open Access
Research article

Christina G Jespersen, Mette Nørgaard, Truls E Bjerklund Johansen, Mette Søgaard, Michael Borre

Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation

Open Access
Research article

Jessica ES Bohonowych, Shuping Peng, Udhayakumar Gopal, Michael W Hance, Shane B Wing, Kelley M Argraves, Karen Lundgren, Jennifer S Isaacs

Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide

Open Access
Research article

Tao Yan, Kai Ove Skaftnesmo, Lina Leiss, Linda Sleire, Jian Wang, Xingang Li, Per Øyvind Enger

Micro-RNAs as diagnostic or prognostic markers in human epithelial malignancies

Open Access
Review

Angela Hui, Christine How, Emma Ito, Fei-Fei Liu

The association of APE1 −656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies

Open Access
Research article

Bin Zhou, Hailin Shan, Ying Su, Kai Xia, Xiaxia Shao, Weidong Mao, Qing Shao

RETRACTED ARTICLE: Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells

Open Access
Research article

Bin Wu, Ji Li, Damao Huang, Weiwei Wang, Yu Chen, Youxiang Liao, Xiaowei Tang, Hongfu Xie, Faqing Tang

Association between chronic viral hepatitis infection and breast cancer risk: a nationwide population-based case-control study

Open Access
Research article

Fu-Hsiung Su, Shih-Ni Chang, Pei-Chun Chen, Fung-Chang Sung, Chien-Tien Su, Chih-Ching Yeh

Chemotherapeutic errors in hospitalised cancer patients: attributable damage and extra costs

Open Access
Research article

Florence Ranchon, Gilles Salles, Hans-Martin Späth, Vérane Schwiertz, Nicolas Vantard, Stéphanie Parat, Florence Broussais, Benoît You, Sophie Tartas, Pierre Jean Souquet, Claude Dussart, Claire Falandry, Emilie Henin, Gilles Freyer, Catherine Rioufol

Ki67, chemotherapy response, and prognosis in breast cancer patients receiving neoadjuvant treatment

Open Access
Research article

Peter A Fasching, Katharina Heusinger, Lothar Haeberle, Melitta Niklos, Alexander Hein, Christian M Bayer, Claudia Rauh, Ruediger Schulz-Wendtland, Mayada R Bani, Michael Schrauder, Laura Kahmann, Michael P Lux, Johanna D Strehl, Arndt Hartmann, Arno Dimmler, Matthias W Beckmann, David L Wachter

Expression of delta-catenin is associated with progression of human astrocytoma

Open Access
Research article

Wang MingHao, Dong Qianze, Zhang Di, Wang YunJie

Prospective study of physical activity and risk of squamous cell carcinoma of the skin

Open Access
Research article

Petra H Lahmann, Anne Russell, Adèle C Green

The breast cancer genome - a key for better oncology

Open Access
Review

Hans Kristian Moen Vollan, Carlos Caldas

Efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases: a randomized controlled trial

Open Access
Study protocol

Daniel A Galvão, Dennis R Taaffe, Prue Cormie, Nigel Spry, Suzanne K Chambers, Carolyn Peddle-McIntyre, Michael Baker, James Denham, David Joseph, Geoff Groom, Robert U Newton

SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer

Open Access
Research article

Jens Neumann, Fiorina Bahr, David Horst, Lydia Kriegl, Jutta Engel, Raquel Mejías-Luque, Markus Gerhard, Thomas Kirchner, Andreas Jung

Inhibition of N-linked glycosylation impairs ALK phosphorylation and disrupts pro-survival signaling in neuroblastoma cell lines

Open Access
Research article

Federica Del Grosso, Marilena De Mariano, Lorena Passoni, Roberto Luksch, Gian Paolo Tonini, Luca Longo

Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo

Open Access
Research article

Dimitris Anastassiou, Viktoria Rumjantseva, Weiyi Cheng, Jianzhong Huang, Peter D Canoll, Darrell J Yamashiro, Jessica J Kandel

A decade of progress in cancer research

Open Access
Editorial

Christna Chap, Jigisha Patel

Decreased expression of 17β-hydroxysteroid dehydrogenase type 1 is associated with DNA hypermethylation in colorectal cancer located in the proximal colon

Open Access
Research article

Agnieszka Anna Rawłuszko, Karolina Horbacka, Piotr Krokowicz, Paweł Piotr Jagodziński

Improved blood tests for cancer screening: general or specific?

Open Access
Commentary

Ian A Cree

Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma

Open Access
Research article

Keiko Matsuura, Chisato Nakada, Mizuho Mashio, Takahiro Narimatsu, Taichiro Yoshimoto, Masato Tanigawa, Yoshiyuki Tsukamoto, Naoki Hijiya, Ichiro Takeuchi, Takeo Nomura, Fuminori Sato, Hiromitsu Mimata, Masao Seto, Masatsugu Moriyama

Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma

Open Access
Research article

Sucheta Telang, Mary Ann Rasku, Amy L Clem, Karen Carter, Alden C Klarer, Wesley R Badger, Rebecca A Milam, Shesh N Rai, Jianmin Pan, Hana Gragg, Brian F Clem, Kelly M McMasters, Donald M Miller, Jason Chesney

Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events

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Research article

Hani Kim, Lisa C Gillis, Jordan D Jarvis, Stuart Yang, Kai Huang, Sandy Der, Dwayne L Barber

Identification of α(1,6)fucosylated proteins differentially expressed in human colorectal cancer

Open Access
Research article

Laura Muinelo-Romay, Susana Villar-Portela, Elisa Cuevas, Emilio Gil-Martín, Almudena Fernández-Briera

Clinical features and prognostic factors in patients with bone metastases from hepatocellular carcinoma after liver transplantation

Open Access
Research article

Jian He, Zhao-Chong Zeng, Jia Fan, Jian Zhou, Jing Sun, Bing Chen, Ping Yang, Bin-Liang Wang, Bo-Heng Zhang, Jian-Ying Zhang

Phase I-II study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell cancer

Open Access
Study protocol

Charlotte M Huijts, Saskia J Santegoets, Alfons J van den Eertwegh, Laura S Pijpers, John B Haanen, Tanja D de Gruijl, Henk M Verheul, Hans J van der Vliet

Induction of B-cell lymphoma by UVB Radiation in p53 Haploinsufficient Mice

Open Access
Research article

Nahum Puebla-Osorio, Yasuko Miyahara, Sreevidya Coimbatore, Alberto Y Limón-Flores, Nasser Kazimi, Stephen E Ullrich, Chengming Zhu

Determinants of patient satisfaction in ambulatory oncology: a cross sectional study based on the OUT-PATSAT35 questionnaire

Open Access
Research article

Nguyen Thanh Vân France, Jean-François Bosset, Alain Monnier, Jacqueline Fournier, Valérie Perrin, Cédric Baumann, Anne Brédart, Mariette Mercier

Clinical responses to EGFR-tyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis

Open Access
Research article

Satoshi Watanabe, Junta Tanaka, Takeshi Ota, Rie Kondo, Hiroshi Tanaka, Hiroshi Kagamu, Kosuke Ichikawa, Jun Koshio, Junko Baba, Takao Miyabayashi, Ichiei Narita, Hirohisa Yoshizawa

The impact of audit and feedback on nodal harvest in colorectal cancer

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Research article

Geoffrey A Porter, Robin Urquhart, Jingyu Bu, Paul Johnson, Eva Grunfeld

Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis

Open Access
Research article

Yutaka Nakanishi, Hidenori Shiraha, Shin-ichi Nishina, Shigetomi Tanaka, Minoru Matsubara, Shigeru Horiguchi, Masaya Iwamuro, Nobuyuki Takaoka, Masayuki Uemura, Kenji Kuwaki, Hiroaki Hagihara, Junichi Toshimori, Hideki Ohnishi, Akinobu Takaki, Shinichiro Nakamura, Yoshiyuki Kobayashi, Kazuhiro Nouso, Takahito Yagi, Kazuhide Yamamoto

Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression

Open Access
Research article

Carina Roth, Klaus Pantel, Volkmar Müller, Brigitte Rack, Sabine Kasimir-Bauer, Wolfgang Janni, Heidi Schwarzenbach

Factors influencing general practitioners in the referral of elderly cancer patients

Open Access
Research article

Fleur Delva, Emilie Marien, Marianne Fonck, Muriel Rainfray, Jean-Louis Demeaux, Philippe Moreaud, Pierre Soubeyran, Annie J Sasco, Simone Mathoulin-Pélissier

Behavioral and psychosocial effects of rapid genetic counseling and testing in newly diagnosed breast cancer patients: Design of a multicenter randomized clinical trial

Open Access
Study protocol

Marijke R Wevers, Margreet GEM Ausems, Senno Verhoef, Eveline MA Bleiker, Daniela EE Hahn, Frans BL Hogervorst, Rob B van der Luijt, Heiddis B Valdimarsdottir, Richard van Hillegersberg, Emiel JTh Rutgers, Neil K Aaronson

Characterization of ERK Docking Domain Inhibitors that Induce Apoptosis by Targeting Rsk-1 and Caspase-9

Open Access
Research article

Sarice R Boston, Rahul Deshmukh, Scott Strome, U Deva Priyakumar, Alexander D MacKerell Jr, Paul Shapiro

Pattern of lateral neck metastases in N0 papillary thyroid carcinoma

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Research article

Vincent Patron, Cécile Bedfert, Guy Le Clech, Karine Aubry, Franck Jegoux

A human ribonuclease induces apoptosis associated with p21WAF1/CIP1induction and JNK inactivation

Open Access
Research article

Jessica Castro, Marc Ribó, Susanna Navarro, Maria Victòria Nogués, Maria Vilanova, Antoni Benito

Support vector machine model for diagnosis of lymph node metastasis in gastric cancer with multidetector computed tomography: a preliminary study

Open Access
Research article

Xiao-Peng Zhang, Zhi-Long Wang, Lei Tang, Ying-Shi Sun, Kun Cao, Yun Gao

ABI3 ectopic expression reduces in vitro and in vivocell growth properties while inducing senescence

Open Access
Research article

Flavia RM Latini, Jefferson P Hemerly, Beatriz CG Freitas, Gisele Oler, Gregory J Riggins, Janete M Cerutti

Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancer

Open Access
Research article

Linn Woelber, Kerstin Kress, Jan F Kersten, Matthias Choschzick, Ergin Kilic, Uwe Herwig, Christoph Lindner, Joerg Schwarz, Fritz Jaenicke, Sven Mahner, Karin Milde-Langosch, Volkmar Mueller, Maike Ihnen

Erratum to: triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival

Open Access
Erratum

Yoon-La Choi, Ensel Oh, Sarah Park, Yeonju Kim, Yeon-Hee Park, Kyug Song, Eun Yoon Cho, Yun-Chul Hong, Jong Sun Choi, Jeong Eon Lee, Jung Han Kim, Seok Jin Nam, Young-Hyuck Lim, Jung-Hyun Yang, Young Kee Shin

Expression profile of the N-myc Downstream Regulated Gene 2 (NDRG2) in human cancers with focus on breast cancer

Open Access
Research article

Anders Lorentzen, Rikke H Lewinsky, Jette Bornholdt, Lotte K Vogel, Cathy Mitchelmore

Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer

Open Access
Research article

Niranjan Awasthi, Amanda Kirane, Margaret A Schwarz, Jason E Toombs, Rolf A Brekken, Roderich E Schwarz

Can Bcl-XL expression predict the radio sensitivity of Bilharzial-related squamous bladder carcinoma? a prospective comparative study

Open Access
Research article

Ahmad M Abdel Raheem, Diaa A Hameed, Ehab O ElGanainy, Eman Mosad, Mostafa E Abdelwanis, Nermen A Kamel, Hisham M Hammouda, Mohammad A Abdelaziz, Khaled Hemeyda

Retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the E7 oncoprotein in HPV 16-positive cells

Open Access
Research article

Luisa Accardi, Maria Gabriella Donà, Anna M Mileo, Marco G Paggi, Antonio Federico, Paola Torreri, Tamara C Petrucci, Rosita Accardi, David Pim, Massimo Tommasino, Lawrence Banks, Barbara Chirullo, Colomba Giorgi

A novel insight of sentinel lymph node concept based on 1-3 positive nodes in patients with pT1-2 gastric cancer

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Research article

Baojun Huang, Zhenning Wang, Zhe Sun, Bo Zhao, Huimian Xu

Classical homeopathy in the treatment of cancer patients - a prospective observational study of two independent cohorts

Open Access
Research article

Matthias Rostock, Johannes Naumann, Corina Guethlin, Lars Guenther, Hans H Bartsch, Harald Walach

Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals

Open Access
Research article

Meei-Shyuan Lee, Chih-Cheng Hsu, Mark L Wahlqvist, Hsin-Ni Tsai, Yu-Hung Chang, Yi-Chen Huang

Long term outcome of high-risk neuroblastoma patients after immunotherapy with antibody ch14.18 or oral metronomic chemotherapy

Open Access
Research article

Thorsten Simon, Barbara Hero, Andreas Faldum, Rupert Handgretinger, Martin Schrappe, Thomas Klingebiel, Frank Berthold

Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel

Open Access
Research article

Chun-Fang Zou, Luoqi Jia, Hongyan Jin, Ming Yao, Naiqing Zhao, Jin Huan, Zhen Lu, Robert C Bast Jr, Youji Feng, Yinhua Yu

Intracranial metastasis from primary transitional cell carcinoma of female urethra: case report & review of the literature

Open Access
Case report

Kyung-Sub Moon, Shin Jung, Kyung-Hwa Lee, Eu Chang Hwang, In-Young Kim

Bim and Mcl-1 exert key roles in regulating JAK2V617Fcell survival

Open Access
Research article

Joëlle Rubert, Zhiyan Qian, Rita Andraos, Daniel A Guthy, Thomas Radimerski

Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis

Open Access
Research article

Michel S Beausoleil, Erika B Schulze, David Goodale, Carl O Postenka, Alison L Allan

Fish consumption and the risk of gastric cancer: systematic review and meta-analysis

Open Access
Research article

Shengjun Wu, Jie Liang, Lei Zhang, Xia Zhu, Xufeng Liu, Danmin Miao

Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women

Open Access
Research article

Suresh Hedau, Umesh Kumar, Showket Hussain, Shirish Shukla, Shailja Pande, Neeraj Jain, Abhishek Tyagi, Trivikram Deshpande, Dilafroze Bhat, Mohammad Muzaffar Mir, Sekhar Chakraborty, Y Mohan Singh, Rakesh Kumar, Kumaravel Somasundaram, Alok C Bharti, Bhudev C Das

Antiangiogenic effects of pazopanib in xenograft hepatocellular carcinoma models: evaluation by quantitative contrast-enhanced ultrasonography

Open Access
Research article

Xiao-Dong Zhu, Ju-Bo Zhang, Pei-Li Fan, Yu-Quan Xiong, Peng-Yuan Zhuang, Wei Zhang, Hua-Xiang Xu, Dong-Mei Gao, Ling-Qun Kong, Lu Wang, Wei-Zhong Wu, Zhao-You Tang, Hong Ding, Hui-Chuan Sun

Incidence of bone metastases and skeletal-related events in breast cancer patients: A population-based cohort study in Denmark

Open Access
Research article

Annette Ø Jensen, Jacob B Jacobsen, Mette Nørgaard, Mellissa Yong, Jon P Fryzek, Henrik T Sørensen

Identification and Regulation of c-Myb Target Genes in MCF-7 Cells

Open Access
Research article

Anita M Quintana, Fan Liu, John P O'Rourke, Scott A Ness

Tumor-suppressor activity of RRIG1 in breast cancer

Open Access
Research article

Guihong Zhang, Abenaa Brewster, Baoxiang Guan, Zhen Fan, Powel H Brown, Xiao-Chun Xu

MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma

Open Access
Research article

Amanda Tivnan, Lorraine Tracey, Patrick G Buckley, Leah C Alcock, Andrew M Davidoff, Raymond L Stallings

Morbidity, life style and psychosocial situation in cancer survivors aged 60-69 years: results from The Nord-Trøndelag Health Study (The HUNT-II Study)

Open Access
Research article

Ellen K Grov, Sophie D Fosså, Alv A Dahl

O6-Methylguanine-DNA methyltransferase protein expression by immunohistochemistry in brain and non-brain systemic tumours: systematic review and meta-analysis of correlation with methylation-specific polymerase chain reaction

Open Access
Research article

Marta Brell, Javier Ibáñez, Avelina Tortosa

Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer

Open Access
Research article

Chen-Hsi Hsieh, Ying-Shiung Kuo, Li-Jen Liao, Kawang-Yu Hu, Shih-Chiang Lin, Le-Jung Wu, Yu-Chin Lin, Yu-Jen Chen, Li-Ying Wang, Yen-Ping Hsieh, Shoei Long Lin, Chun-Yi Chen, Chien-An Chen, Pei-Wei Shueng

FLT3 mutations in canine acute lymphocytic leukemia

Open Access
Research article

Steven E Suter, George W Small, Eric L Seiser, Rachael Thomas, Matthew Breen, Kristy L Richards

In vivo imaging of pancreatic tumours and liver metastases using 7 Tesla MRI in a murine orthotopic pancreatic cancer model and a liver metastases model

Open Access
Research article

Ivo L Partecke, André Kaeding, Matthias Sendler, Nele Albers, Jens-P Kühn, Sven Speerforck, Sebastian Roese, Florian Seubert, Stephan Diedrich, Sandra Kuehn, Ulrich F Weiss, Julia Mayerle, Markus M Lerch, Stefan Hadlich, Norbert Hosten, Claus-D Heidecke, Ralf Puls, Wolfram von Bernstorff

Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma

Open Access
Research article

Claudia Lengerke, Tanja Fehm, Ralf Kurth, Hans Neubauer, Veit Scheble, Friederike Müller, Friederike Schneider, Karen Petersen, Diethelm Wallwiener, Lothar Kanz, Falko Fend, Sven Perner, Petra M Bareiss, Annette Staebler

Oncolytic targeting of androgen-sensitive prostate tumor by the respiratory syncytial virus (RSV): consequences of deficient interferon-dependent antiviral defense

Open Access
Research article

Ibtissam Echchgadda, Te-Hung Chang, Ahmed Sabbah, Imad Bakri, Yuji Ikeno, Gene B Hubbard, Bandana Chatterjee, Santanu Bose

Acceptability of the Distress Thermometer and Problem List to community-based telephone cancer helpline operators, and to cancer patients and carers

Open Access
Research article

Karen L Hughes, Hilary Sargeant, Anna L Hawkes

Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters

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Junlin Li, Binhua P Zhou

Mechanisms of confluence-dependent expression of CD26 in colon cancer cell lines

Open Access
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Masako Abe, Pamela A Havre, Yasuyo Urasaki, Kei Ohnuma, Chikao Morimoto, Long H Dang, Nam H Dang

A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A (ECRG1) to inhibit cancer cell growth in esophageal carcinoma

Open Access
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Lin-wei Li, Yuan-yuan Li, Xiao-yan Li, Chun-peng Zhang, Yun Zhou, Shih-Hsin Lu

Serum antibodies against genitourinary infectious agents in prostate cancer and benign prostate hyperplasia patients: a case-control study

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Jan Hrbacek, Michael Urban, Eva Hamsikova, Ruth Tachezy, Vaclav Eis, Marek Brabec, Jiri Heracek

Protein secretion in human mammary epithelial cells following HER1 receptor activation: influence of HER2 and HER3 expression

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Yi Zhang, Rachel M Gonzalez, Richard C Zangar

Neoadjuvant imatinib in patients with locally advanced non metastatic GIST in the prospective BFR14 trial

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c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients

Open Access
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André O von Bueren, Christoph Oehler, Tarek Shalaby, Katja von Hoff, Martin Pruschy, Burkhardt Seifert, Nicolas U Gerber, Monika Warmuth-Metz, Duncan Stearns, Charles G Eberhart, Rolf D Kortmann, Stefan Rutkowski, Michael A Grotzer

Effects on quality of life of weekly docetaxel-based chemotherapy in patients with locally advanced or metastatic breast cancer: results of a single-centre randomized phase 3 trial

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Francesco Nuzzo, Alessandro Morabito, Adriano Gravina, Francesca Di Rella, Gabriella Landi, Carmen Pacilio, Vincenzo Labonia, Emanuela Rossi, Ermelinda De Maio, Maria Carmela Piccirillo, Giuseppe D'Aiuto, Renato Thomas, Massimo Rinaldo, Gerardo Botti, Maurizio Di Bonito, Massimo Di Maio, Ciro Gallo, Francesco Perrone, Andrea de Matteis

Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

Open Access
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Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma

Open Access
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Identification and validation of genes involved in cervical tumourigenesis

Open Access
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Thangarajan Rajkumar, Kesavan Sabitha, Neelakantan Vijayalakshmi, Sundersingh Shirley, Mayil Vahanan Bose, Gopisetty Gopal, Ganesharaja Selvaluxmy

Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells

Open Access
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Wataru Habano, Toshie Gamo, Jun Terashima, Tamotsu Sugai, Koki Otsuka, Go Wakabayashi, Shogo Ozawa

Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells

Open Access
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The relative risk of second primary cancers in Queensland, Australia: a retrospective cohort study

Open Access
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Danny R Youlden, Peter D Baade

Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma

Open Access
Research article

Fajun Xie, Haibo Liu, Ying-Hui Zhu, Yan-Ru Qin, Yongdong Dai, Tingting Zeng, Leilei Chen, Changjun Nie, Hong Tang, Yan Li, Li Fu, Xin-Yuan Guan

Diet folate, DNA methylation and genetic polymorphisms of MTHFRC677T in association with the prognosis of esophageal squamous cell carcinoma

Open Access
Research article

Cheng Lu, Hui Xie, Fengliang Wang, Hongbing Shen, Jianming Wang

Manual lymphatic drainage therapy in patients with breast cancer related lymphoedema

Open Access
Study protocol

Marta López Martín, Miguel A Hernández, Cristina Avendaño, Francisco Rodríguez, Helena Martínez

Validation of prognostic scores for survival in cancer patients beyond first-line therapy

Open Access
Research article

Olivier Trédan, Isabelle Ray-Coquard, Gisèle Chvetzoff, Paul Rebattu, Agathe Bajard, Sylvie Chabaud, David Pérol, Chadi Saba, Florent Quiblier, Jean-Yves Blay, Thomas Bachelot

Coffee consumption and risk of cancers: a meta-analysis of cohort studies

Open Access
Research article

Xiaofeng Yu, Zhijun Bao, Jian Zou, Jie Dong

Resveratrol protects leukemic cells against cytotoxicity induced by proteasome inhibitors via induction of FOXO1 and p27Kip1

Open Access
Research article

Xiao-Fang Niu, Bao-Qin Liu, Zhen-Xian Du, Yan-Yan Gao, Chao Li, Ning Li, Yifu Guan, Hua-Qin Wang

CXCL12 expression by healthy and malignant ovarian epithelial cells

Open Access
Research article

Véronique Machelon, Françoise Gaudin, Sophie Camilleri-Broët, Salam Nasreddine, Laurence Bouchet-Delbos, Eric Pujade-Lauraine, Jerôme Alexandre, Laurence Gladieff, Fernando Arenzana-Seisdedos, Dominique Emilie, Sophie Prévot, Philippe Broët, Karl Balabanian

Phase II study of preoperative radiation plus concurrent daily tegafur-uracil (UFT) with leucovorin for locally advanced rectal cancer

Open Access
Research article

Patrice Cellier, Bernard Leduc, Laurent Martin, Brigitte Vié, Christian Chevelle, Véronique Vendrely, Augustin Salemkour, Christian Carrie, Gilles Calais, Pascal Burtin, Loïc Campion, Michèle Boisdron-Celle, Alain Morel, Virginie Berger, Erick Gamelin

Correlation of SHOX2 Gene Amplification and DNA Methylation in Lung Cancer Tumors

Open Access
Research article

Katja U Schneider, Dimo Dietrich, Michael Fleischhacker, Gunda Leschber, Johannes Merk, Frank Schäper, Henk R Stapert, Erik R Vossenaar, Sabine Weickmann, Volker Liebenberg, Christoph Kneip, Anke Seegebarth, Fikret Erdogan, Gudrun Rappold, Bernd Schmidt

Impact of PINCH expression on survival in colorectal cancer patients

Open Access
Research article

Jasmine Lööf, Johan Rosell, Charlotte Bratthäll, Siv Doré, Hans Starkhammar, Hong Zhang, Xiao-Feng Sun

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In vitro Fertilisation
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Eine australische Studie hat die Krebsinzidenz bei Frauen nach medizinisch assistierter Reproduktion (MAR) untersucht. Insgesamt entspricht das Risiko dem der Allgemeinbevölkerung, einzelne Tumorarten treten jedoch häufiger oder seltener auf.

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