BMC Cancer

Inhalt (627 Artikel)

HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast

Open Access
Research article

Sophie Doublier, Dimas C Belisario, Manuela Polimeni, Laura Annaratone, Chiara Riganti, Elena Allia, Dario Ghigo, Amalia Bosia, Anna Sapino

Volumetric and MGMT parameters in glioblastoma patients: Survival analysis

Open Access
Research article

Georgios Iliadis, Vassiliki Kotoula, Athanasios Chatzisotiriou, Despina Televantou, Anastasia G Eleftheraki, Sofia Lambaki, Despina Misailidou, Panagiotis Selviaridis, George Fountzilas

Cholesterol and the risk of grade-specific prostate cancer incidence: evidence from two large prospective cohort studies with up to 37 years' follow up

Open Access
Research article

Kashif Shafique, Philip McLoone, Khaver Qureshi, Hing Leung, Carole Hart, David S Morrison

Incidence and survival of oesophageal and gastric cancer in England between 1998 and 2007, a population-based study

Open Access
Research article

Victoria H Coupland, William Allum, Jane M Blazeby, Michael A Mendall, Richard H Hardwick, Karen M Linklater, Henrik Møller, Elizabeth A Davies

Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation

Open Access
Research article

Ingrid Moen, Charlotte Jevne, Jian Wang, Karl-Henning Kalland, Martha Chekenya, Lars A Akslen, Linda Sleire, Per Ø Enger, Rolf K Reed, Anne M Øyan, Linda EB Stuhr

Induction of cell proliferation and survival genes by estradiol-repressed microRNAs in breast cancer cells

Open Access
Research article

Xinfeng Yu, Xuemei Zhang, Ishwori B Dhakal, Marjorie Beggs, Susan Kadlubar, Dali Luo

"A novel in vivo model for the study of human breast cancer metastasis using primary breast tumor-initiating cells from patient biopsies"

Open Access
Research article

Carolyn G Marsden, Mary Jo Wright, Latonya Carrier, Krzysztof Moroz, Radhika Pochampally, Brian G Rowan

TGF-β1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells

Open Access
Research article

Luciana R Gomes, Letícia F Terra, Rosângela AM Wailemann, Leticia Labriola, Mari C Sogayar

Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer

Open Access
Research article

Isabelle Dufau, Céline Frongia, Flavie Sicard, Laure Dedieu, Pierre Cordelier, Frédéric Ausseil, Bernard Ducommun, Annie Valette

A common variant of the MACC1 gene is significantly associated with overall survival in colorectal cancer patients

Open Access
Research article

Alois H Lang, Simone Geller-Rhomberg, Thomas Winder, Nicole Stark, Klaus Gasser, Bernd Hartmann, Bertram Kohler, Ina Grizelj, Heinz Drexel, Axel Muendlein

A randomised controlled trial of a theory-based intervention to improve sun protective behaviour in adolescents ('you can still be HOT in the shade'): study protocol

Open Access
Study protocol

Anna L Hawkes, Kyra Hamilton, Katherine M White, Ross McD Young

Diagnostic value of fine-needle aspiration biopsy for breast mass: a systematic review and meta-analysis

Open Access
Research article

Ying-Hua Yu, Wei Wei, Jian-Lun Liu

Predictive and prognostic value of circulating nucleosomes and serum biomarkers in patients with metastasized colorectal cancer undergoing Selective Internal Radiation Therapy

Open Access
Research article

Yvonne Nadine Fahmueller, Dorothea Nagel, Ralf-Thorsten Hoffmann, Klaus Tatsch, Tobias Jakobs, Petra Stieber, Stefan Holdenrieder

Contribution of cell blocks obtained through endobronchial ultrasound-guided transbronchial needle aspiration to the diagnosis of lung cancer

Open Access
Research article

José Sanz-Santos, Pere Serra, Felipe Andreo, Maria Llatjós, Eva Castellà, Eduard Monsó

Biomarkers for antitumor activity of bevacizumab in gastric cancer models

Open Access
Research article

Yoriko Yamashita-Kashima, Kaori Fujimoto-Ouchi, Keigo Yorozu, Mitsue Kurasawa, Mieko Yanagisawa, Hideyuki Yasuno, Kazushige Mori

Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer

Open Access
Research article

J Sven D Mieog, Esther M de Kruijf, Esther Bastiaannet, Peter JK Kuppen, Anita Sajet, Anton JM de Craen, Vincent THBM Smit, Cornelis JH van de Velde, Gerrit-Jan Liefers

Expression and clinical significance of extracellular matrix protein 1 and vascular endothelial growth factor-C in lymphatic metastasis of human breast cancer

Open Access
Research article

Qiu-Wan Wu, Hong-Qiang She, Jing Liang, Yu-Fan Huang, Qing-Mo Yang, Qiao-Lu Yang, Zhi-Ming Zhang

Transarterial chemoembolization plus or minus intravenous bevacizumab in the treatment of hepatocellular cancer: A pilot study

Open Access
Research article

Carolyn D Britten, Antoinette S Gomes, Zev A Wainberg, David Elashoff, Rafael Amado, Yan Xin, Ronald W Busuttil, Dennis J Slamon, Richard S Finn

Obesity, body composition, and prostate cancer

Open Access
Research article

Jay H Fowke, Saundra S Motley, Raoul S Concepcion, David F Penson, Daniel A Barocas

NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study

Open Access
Research article

Esther M de Kruijf, Anita Sajet, Johanna GH van Nes, Hein Putter, Vincent THBM Smit, Robert A Eagle, Insiya Jafferji, John Trowsdale, Gerrit Jan Liefers, Cornelis JH van de Velde, Peter JK Kuppen

Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells

Open Access
Research article

Yun-Hee Rhee, Soo-Jin Jeong, Hyo-Jeong Lee, Hyo-Jung Lee, Wonil Koh, Ji Hoon Jung, Sun-Hee Kim, Kim Sung-Hoon

Axillary node metastasis from differentiated thyroid carcinoma with hürthle and signet ring cell differentiation. A case of disseminated thyroid cancer with peculiar histologic findings

Open Access
Case report

Maria Grazia Chiofalo, Nunzia Simona Losito, Franco Fulciniti, Sergio Venanzio Setola, Antonio Tommaselli, Ugo Marone, Maria Luisa Di Cecilia, Luciano Pezzullo

Why do results conflict regarding the prognostic value of the methylation status in colon cancers? the role of the preservation method

Open Access
Research article

Benjamin Tournier, Caroline Chapusot, Emilie Courcet, Laurent Martin, Côme Lepage, Jean Faivre, Françoise Piard

Golgi protein 73 versus alpha-fetoprotein as a biomarker for hepatocellular carcinoma: a diagnostic meta- analysis

Open Access
Research article

Ying Zhou, Xin Yin, Jun Ying, BoHeng Zhang

Anti-apoptotic gene transcription signature of salivary gland neoplasms

Open Access
Research article

Carolina Cavaliéri Gomes, Vanessa Fátima Bernardes, Marina Gonçalves Diniz, Luiz De Marco, Ricardo Santiago Gomez

Second-line Treatment of Stage III/IV Non-Small-Cell Lung Cancer (NSCLC) with pemetrexed in routine clinical practice: Evaluation of performance status and health-related quality of life

Open Access
Research article

Wolfgang Schuette, Hans Tesch, Hartwig Büttner, Thomas Krause, Victoria Soldatenkova, Clemens Stoffregen

Risk factors associated with fatal pulmonary hemorrhage in locally advanced non-small cell lung cancer treated with chemoradiotherapy

Open Access
Research article

Masami Ito, Seiji Niho, Keiji Nihei, Kiyotaka Yoh, Hironobu Ohmatsu, Yuichiro Ohe

Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review

Open Access
Research article

Susanne Hartwig, Stina Syrjänen, Géraldine Dominiak-Felden, Maria Brotons, Xavier Castellsagué

Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma

Open Access
Research article

Seiki Miura, Noboru Mitsuhashi, Hiroaki Shimizu, Fumio Kimura, Hiroyuki Yoshidome, Masayuki Otsuka, Atsushi Kato, Takashi Shida, Daiki Okamura, Masaru Miyazaki

Space-time clustering of childhood central nervous system tumours in Yorkshire, UK

Open Access
Research article

Richard JQ McNally, Peter W James, Susan V Picton, Patricia A McKinney, Marlous van Laar, Richard G Feltbower

The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer

Open Access
Research article

Mohammad Al Sorkhy, Rosa-Maria Ferraiuolo, Espanta Jalili, Agnes Malysa, Andreea R Fratiloiu, Bonnie F Sloane, Lisa A Porter

Cost-utility analysis of adjuvant goserelin (Zoladex) and adjuvant chemotherapy in premenopausal women with breast cancer

Open Access
Research article

Tsui Fen Cheng, Jung Der Wang, Wu Ching Uen

Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis

Open Access
Research article

Seung Joon Lee, Sigrid A Langhans

Methylation of the KEAP1 gene promoter region in human colorectal cancer

Open Access
Research article

Naoyuki Hanada, Takenori Takahata, Qiliang Zhou, Xulu Ye, Ruowen Sun, Jugoh Itoh, Atsushi Ishiguro, Hiroshi Kijima, Junsei Mimura, Ken Itoh, Shinsaku Fukuda, Yasuo Saijo

DNA methylation regulates expression of VEGF-R2 (KDR) and VEGF-R3 (FLT4)

Open Access
Research article

Hilmar Quentmeier, Sonja Eberth, Julia Romani, Herbert A Weich, Margarete Zaborski, Hans G Drexler

Disruption of CTCF at the miR-125b1 locus in gynecological cancers

Open Access
Research article

Ernesto Soto-Reyes, Rodrigo González-Barrios, Fernanda Cisneros-Soberanis, Roberto Herrera-Goepfert, Víctor Pérez, David Cantú, Diddier Prada, Clementina Castro, Félix Recillas-Targa, Luis A Herrera

Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors

Open Access
Research article

Xiao-Bing Jiang, Chao Ke, Guan-Hua Zhang, Xiang-Heng Zhang, Ke Sai, Zhong-Ping Chen, Yong-Gao Mou

Laparoscopy to predict the result of primary cytoreductive surgery in advanced ovarian cancer patients (LapOvCa-trial): a multicentre randomized controlled study

Open Access
Study protocol

Marianne J Rutten, Katja N Gaarenstroom, Toon Van Gorp, Hannah S van Meurs, Henriette JG Arts, Patrick M Bossuyt, Henk G Ter Brugge, Ralph HM Hermans, Brent C Opmeer, Johanna MA Pijnenborg, Henk WR Schreuder, Eltjo MJ Schutter, Anje M Spijkerboer, Celesta WM Wensveen, Petra Zusterzeel, Ben Willem J Mol, Gemma G Kenter, Marrije R Buist

Effects of partner proteins on BCA2 RING ligase activity

Open Access
Research article

Stephanie Bacopulos, Yutaka Amemiya, Wenyi Yang, Judit Zubovits, Angelika Burger, Martin Yaffe, Arun K Seth

Improving adherence to surveillance and screening recommendations for people with colorectal cancer and their first degree relatives: a randomized controlled trial

Open Access
Study protocol

Mariko Carey, Rob Sanson-Fisher, Finlay Macrae, David Hill, Catherine D'Este, Christine Paul, Christopher Doran

Cancer-initiating cells derived from established cervical cell lines exhibit stem-cell markers and increased radioresistance

Open Access
Research article

Jacqueline López, Adela Poitevin, Veverly Mendoza-Martínez, Carlos Pérez-Plasencia, Alejandro García-Carrancá

Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

Open Access
Research article

Jing Shi, Demao Yao, Wei Liu, Na Wang, Hongjun Lv, Guanjun Zhang, Meiju Ji, Li Xu, Nongyue He, Bingyin Shi, Peng Hou

Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation

Open Access
Research article

Alejandra B Ochoa-Hernández, Moisés Ramos-Solano, Ivan D Meza-Canales, Beatriz García-Castro, Mónica A Rosales-Reynoso, Judith A Rosales-Aviña, Esperanza Barrera-Chairez, Pablo C Ortíz-Lazareno, Georgina Hernández-Flores, Alejandro Bravo-Cuellar, Luis F Jave-Suarez, Patricio Barros-Núñez, Adriana Aguilar-Lemarroy

PINCH is an independent prognostic factor in rectal cancer patients without preoperative radiotherapy - a study in a Swedish rectal cancer trial of preoperative radiotherapy

Open Access
Research article

Annica Holmqvist, Jingfang Gao, Birgitta Holmlund, Gunnar Adell, John Carstensen, Dianne Langford, Xiao-Feng Sun

Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries

Open Access
Research article

Erika Maria Monteiro Santos, Mev Dominguez Valentin, Felipe Carneiro, Ligia Petrolini de Oliveira, Fabio de Oliveira Ferreira, Samuel Aguiar Junior, Wilson Toshihiko Nakagawa, Israel Gomy, Victor Evangelista de Faria Ferraz, Wilson Araujo da Silva Junior, Dirce Maria Carraro, Benedito Mauro Rossi

Frequency of CDH1 germline mutations in gastric carcinoma coming from high- and low-risk areas: metanalysis and systematic review of the literature

Open Access
Research article

Giovanni Corso, Daniele Marrelli, Valeria Pascale, Carla Vindigni, Franco Roviello

Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia

Open Access
Research article

Marcela Braga Mansur, Rocio Hassan, Thayana C Barbosa, Alessandra Splendore, Patricia Y Jotta, José Andrés Yunes, Joseph L Wiemels, Maria S Pombo-de-Oliveira

Neck control after definitive radiochemotherapy without planned neck dissection in node-positive head and neck cancers

Open Access
Research article

Na Young Jang, Keun-Wook Lee, Soon-Hyun Ahn, Jae-Sung Kim, In-Ah Kim

HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia

Open Access
Research article

Mariska Bierkens, Saskia M Wilting, Wessel N van Wieringen, Mark A van de Wiel, Bauke Ylstra, Chris JLM Meijer, Peter JF Snijders, Renske DM Steenbergen

Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis

Open Access
Research article

Zhigang Cui, Zhihua Yin, Xuelian Li, Wei Wu, Peng Guan, Baosen Zhou

ADAM8 in squamous cell carcinoma of the head and neck: a retrospective study

Open Access
Research article

Valerie Zielinski, Markus Brunner, Gregor Heiduschka, Sven Schneider, Rudolf Seemann, Boban Erovic, Dietmar Thurnher

Androgenic suppression combined with radiotherapy for the treatment of prostate adenocarcinoma: a systematic review

Open Access
Research article

André D Sasse, Elisa Sasse, Albertina M Carvalho, Ligia T Macedo

Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development

Open Access
Research article

Kwong-Him To, Sanja Pajovic, Brenda L Gallie, Brigitte L Thériault

RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls

Open Access
Research article

Mikkel Noerholm, Leonora Balaj, Tobias Limperg, Afshin Salehi, Lin Dan Zhu, Fred H Hochberg, Xandra O Breakefield, Bob S Carter, Johan Skog

Survival after chemotherapy and/or radiotherapy versus self-expanding metal stent insertion in the setting of inoperable esophageal cancer: a case-control study

Open Access
Research article

George Sgourakis, Ines Gockel, Constantine Karaliotas, Markus Moehler, Carl Christoph Schimanski, Heinz Schmidberger, Theodor Junginger

Monitoring physical and psychosocial symptom trajectories in ovarian cancer patients receiving chemotherapy

Open Access
Research article

Verena Meraner, Eva-Maria Gamper, Anna Grahmann, Johannes M Giesinger, Petra Wiesbauer, Monika Sztankay, Alain G Zeimet, Barbara Sperner-Unterweger, Bernhard Holzner

Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy

Open Access
Research article

Maria D Cao, Guro F Giskeødegård, Tone F Bathen, Beathe Sitter, Anna Bofin, Per E Lønning, Steinar Lundgren, Ingrid S Gribbestad

The application of methylation specific electrophoresis (MSE) to DNA methylation analysis of the 5' CpG island of mucin in cancer cells

Open Access
Research article

Seiya Yokoyama, Sho Kitamoto, Norishige Yamada, Izumi Houjou, Tamotsu Sugai, Shin-ichi Nakamura, Yoshifumi Arisaka, Kyoichi Takaori, Michiyo Higashi, Suguru Yonezawa

Human chorionic gonadotropin and its relation to grade, stage and patient survival in ovarian cancer

Open Access
Research article

Miriam Lenhard, Alexandra Tsvilina, Lan Schumacher, Markus Kupka, Nina Ditsch, Doris Mayr, Klaus Friese, Udo Jeschke

The association between Toll-like receptor 2 single-nucleotide polymorphisms and hepatocellular carcinoma susceptibility

Open Access
Research article

Xie Junjie, Jiang Songyao, Shi Minmin, Song Yanyan, Shen Baiyong, Deng Xiaxing, Jin Jiabin, Zhan Xi, Chen Hao

Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells

Open Access
Research article

Peter S Harris, Sujatha Venkataraman, Irina Alimova, Diane K Birks, Andrew M Donson, Jeffrey Knipstein, Adrian Dubuc, Michael D Taylor, Michael H Handler, Nicholas K Foreman, Rajeev Vibhakar

The predictive value of microRNA-126 in relation to first line treatment with capecitabine and oxaliplatin in patients with metastatic colorectal cancer

Open Access
Research article

Torben Frøstrup Hansen, Flemming Brandt Sørensen, Jan Lindebjerg, Anders Jakobsen

KAI1 suppresses HIF-1α and VEGF expression by blocking CDCP1-enhanced Src activation in prostate cancer

Open Access
Research article

Jung-Jin Park, Yeung Bae Jin, Yoon-Jin Lee, Jae-Seon Lee, Yun-Sil Lee, Young-Gyu Ko, Minyoung Lee

Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors

Open Access
Research article

Anne-Katrine Bonde, Verena Tischler, Sushil Kumar, Alex Soltermann, Reto A Schwendener

Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells

Open Access
Research article

Benjamin Blaser, Laurent Waselle, Anne Dormond-Meuwly, Marc Dufour, Didier Roulin, Nicolas Demartines, Olivier Dormond

Pneumatosis intestinalis and portal venous gas secondary to Gefitinib therapy for lung adenocarcinoma

Open Access
Case report

Joo Young Lee, Hye-Suk Han, Sung-Nam Lim, Young Kwang Shim, Yong Hyeok Choi, Ok-Jun Lee, Ki Hyeong Lee, Seung Taik Kim

A population-based cohort study of chest x-ray screening in smokers: lung cancer detection findings and follow-up

Open Access
Research article

Lorenzo Dominioni, Nicola Rotolo, William Mantovani, Albino Poli, Salvatore Pisani, Valentina Conti, Massimo Paolucci, Fausto Sessa, Antonio Paddeu, Vincenzo D'Ambrosio, Andrea Imperatori

Analysis of SLX4/FANCP in non-BRCA1/2-mutated breast cancer families

Open Access
Research article

Juana Fernández-Rodríguez, Francisco Quiles, Ignacio Blanco, Alex Teulé, Lídia Feliubadaló, Jesús del Valle, Mónica Salinas, Àngel Izquierdo, Esther Darder, Detlev Schindler, Gabriel Capellá, Joan Brunet, Conxi Lázaro, Miguel Angel Pujana

Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases

Open Access
Research article

Hidekazu Kuramochi, Go Nakajima, Yuka Kaneko, Ayako Nakamura, Yuji Inoue, Masakazu Yamamoto, Kazuhiko Hayashi

Identification of a biomarker panel for colorectal cancer diagnosis

Open Access
Research article

Amaia García-Bilbao, Rubén Armañanzas, Ziortza Ispizua, Begoña Calvo, Ana Alonso-Varona, Iñaki Inza, Pedro Larrañaga, Guillermo López-Vivanco, Blanca Suárez-Merino, Mónica Betanzos

Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance

Open Access
Research article

Michael Heise, Anja Lautem, Johanna Knapstein, Jörn M Schattenberg, Maria Hoppe-Lotichius, Daniel Foltys, Nina Weiler, Anca Zimmermann, Arno Schad, Dirk Gründemann, Gerd Otto, Peter R Galle, Marcus Schuchmann, Tim Zimmermann

Clinical phase I/II trial to investigate neoadjuvant intensity-modulated short term radiation therapy (5 × 5 gy) and intraoperative radiation therapy (15 gy) in patients with primarily resectable pancreatic cancer - NEOPANC

Open Access
Study protocol

Falk Roeder, Carmen Timke, Ladan Saleh-Ebrahimi, Lutz Schneider, Thilo Hackert, Werner Hartwig, Annette Kopp-Schneider, Frank W Hensley, Markus W Buechler, Juergen Debus, Peter E Huber, Jens Werner

The mediterranean dietary pattern and breast cancer risk in Greek-Cypriot women: a case-control study

Open Access
Research article

Christiana A Demetriou, Andreas Hadjisavvas, Maria A Loizidou, Giorgos Loucaides, Ioanna Neophytou, Sabina Sieri, Eleni Kakouri, Nicos Middleton, Paolo Vineis, Kyriacos Kyriacou

Systematic review: conservative treatments for secondary lymphedema

Open Access
Research article

Mark Oremus, Ian Dayes, Kathryn Walker, Parminder Raina

The TERT rs2736100 Polymorphism and Cancer Risk: A Meta-analysis Based on 25 Case-Control Studies

Open Access
Research article

Peng Zou, Aihua Gu, Guixiang Ji, Lin Zhao, Peng Zhao, Ailin Lu

Fascin overexpression promotes neoplastic progression in oral squamous cell carcinoma

Open Access
Research article

Hunain Alam, Amruta V Bhate, Prakash Gangadaran, Sharda S Sawant, Shimul Salot, Lalit Sehgal, Prerana P Dange, Devendra A Chaukar, Anil K D'cruz, Sadhna Kannanl, Rajiv Gude, Shubhada Kane, Sorab N Dalal, Milind M Vaidya

Anticipating implementation of colorectal cancer screening in The Netherlands: a nation wide survey on endoscopic supply and demand

Open Access
Research article

Sietze T van Turenhout, Jochim S Terhaar sive Droste, Gerrit A Meijer, Ad A Masclée, Chris JJ Mulder

Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion

Open Access
Research article

Zheng-sheng Wu, Chao-qun Wang, Ru Xiang, Xue Liu, Shan Ye, Xue-qing Yang, Gui-hong Zhang, Xiao-chun Xu, Tao Zhu, Qiang Wu

aThe dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer

Open Access
Research article

Gustaf Rosin, Ulf Hannelius, Linda Lindström, Per Hall, Jonas Bergh, Johan Hartman, Juha Kere

Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy

Open Access
Research article

Wenyi Qin, Gerald Gui, Ke Zhang, Dominique Twelves, Beth Kliethermes, Edward R Sauter

Mortality in cancer patients with a history of cutaneous squamous cell carcinoma - a nationwide population-based cohort study

Open Access
Research article

Sigrun Alba Johannesdottir, Timothy L Lash, Annette Østergaard Jensen, Dóra Körmendiné Farkas, Anne Braae Olesen

Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer

Open Access
Research article

Bang Hu, Donglin Ren, Dan Su, Hongcheng Lin, Zhenyu Xian, Xingyang Wan, Junxiao Zhang, Xinhui Fu, Li Jiang, Dechan Diao, Xinjuan Fan, Lei Wang, Jianping Wang

Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells

Open Access
Research article

Miguel A Mendoza-Catalán, Gema R Cristóbal-Mondragón, Jesús Adame-Gómez, Heidi N del Valle-Flores, José Fco Coppe, Laura Sierra-López, Mirna A Romero-Hernández, Luz del Carmen Alarcón-Romero, Berenice Illades-Aguiar, Eduardo Castañeda-Saucedo

Prognostic significance of anti-p53 and anti-KRas circulating antibodies in esophageal cancer patients treated with chemoradiotherapy

Open Access
Research article

Pierre Blanchard, Laurent Quero, Vincent Pacault, Marie-Helene Schlageter, Valerie Baruch-Hennequin, Christophe Hennequin

A mouse model for triple-negative breast cancer tumor-initiating cells (TNBC-TICs) exhibits similar aggressive phenotype to the human disease

Open Access
Research article

Punit Kaur, Ganachari M Nagaraja, Hongying Zheng, Dawit Gizachew, Moses Galukande, Sunil Krishnan, Alexzander Asea

Breast cancer stage at diagnosis and area-based socioeconomic status: a multicenter 10-year retrospective clinical epidemiological study in China

Open Access
Research article

Qiong Wang, Jing Li, Shan Zheng, Jia-Yuan Li, Yi Pang, Rong Huang, Bao-Ning Zhang, Bin Zhang, Hong-Jian Yang, Xiao-Ming Xie, Zhong-Hua Tang, Hui Li, Jian-Jun He, Jin-Hu Fan, You-Lin Qiao

AAV-mediated human PEDF inhibits tumor growth and metastasis in murine colorectal peritoneal carcinomatosis model

Open Access
Research article

Qin Jie Wu, Chang Yang Gong, Shun Tao Luo, Dong Mei Zhang, Shuang Zhang, Hua Shan Shi, Lian Lu, Heng Xiu Yan, Sha Sha He, Dan Dan Li, Li Yang, Xia Zhao, Yu Quan Wei

Promising treatment outcomes of intensity-modulated radiation therapy for nasopharyngeal carcinoma patients with N0 disease according to the seventh edition of the AJCC staging system

Open Access
Research article

Ying Sun, Ling-Long Tang, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Li-Zhi Liu, Ai-Hua Lin, Li Li, Jun Ma

Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased disease-free survival

Open Access
Research article

Ana Slipicevic, Ruth Holm, Elisabeth Emilsen, Anne Katrine Ree Rosnes, Danny R Welch, Gunhild M Mælandsmo, Vivi Ann Flørenes

A randomized controlled trial on the effectiveness of strength training on clinical and muscle cellular outcomes in patients with prostate cancer during androgen deprivation therapy: rationale and design

Open Access
Study protocol

Lene Thorsen, Tormod S Nilsen, Truls Raastad, Kerry S Courneya, Eva Skovlund, Sophie D Fosså

Report on emerging technologies for translational bioinformatics: a symposium on gene expression profiling for archival tissues

Open Access
Correspondence

Levi Waldron, Peter Simpson, Giovanni Parmigiani, Curtis Huttenhower

Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

Open Access
Research article

Luísa Pereira, Pedro Soares, Valdemar Máximo, David C Samuels

Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells

Open Access
Research article

Gustavo A Acuña Sanhueza, Leonie Faller, Babitha George, Jennifer Koffler, Vinko Misetic, Christa Flechtenmacher, Gerhard Dyckhoff, Peter P Plinkert, Peter Angel, Christian Simon, Jochen Hess

Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer

Open Access
Research article

Roxana Schillaci, Pablo Guzmán, Florencia Cayrol, Wendy Beguelin, María C Díaz Flaqué, Cecilia J Proietti, Viviana Pineda, Jorge Palazzi, Isabel Frahm, Eduardo H Charreau, Esteban Maronna, Juan C Roa, Patricia V Elizalde

EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer

Open Access
Research article

Alexandria M Haslehurst, Madhuri Koti, Moyez Dharsee, Paulo Nuin, Ken Evans, Joseph Geraci, Timothy Childs, Jian Chen, Jieran Li, Johanne Weberpals, Scott Davey, Jeremy Squire, Paul C Park, Harriet Feilotter

KRAS rs61764370 is associated with HER2-overexpressed and poorly-differentiated breast cancer in hormone replacement therapy users: a case control study

Open Access
Research article

Jasmina-Ziva Cerne, Vida Stegel, Ksenija Gersak, Srdjan Novakovic

EMMPRIN/CD147 up-regulates urokinase-type plasminogen activator: implications in oral tumor progression

Open Access
Research article

Géraldine Lescaille, Suzanne Menashi, Bénédicte Cavelier-Balloy, Farah Khayati, Cathy Quemener, Marie Pierre Podgorniak, Benyoussef Naïmi, Fabien Calvo, Céleste Lebbe, Samia Mourah

The clinical significance of tumor infiltrating lymphoctyes in breast cancer: does subtype matter?

Open Access
Commentary

Jonathan Krell, Adam E Frampton, Justin Stebbing

Phase I/II trial evaluating carbon ion radiotherapy for the treatment of recurrent rectal cancer: the PANDORA-01 trial

Open Access
Study protocol

Stephanie E Combs, Meinhard Kieser, Daniel Habermehl, Jürgen Weitz, Dirk Jäger, Piero Fossati, Roberto Orrechia, Rita Engenhart-Cabillic, Richard Pötter, Manjit Dosanjh, Oliver Jäkel, Markus W Büchler, Jürgen Debus

LICC: L-BLP25 in patients with colorectal carcinoma after curative resection of hepatic metastases--a randomized, placebo-controlled, multicenter, multinational, double-blinded phase II trial

Open Access
Study protocol

Carl Christoph Schimanski, Markus Möhler, Michael Schön, Eric van Cutsem, Richard Greil, Wolf Otto Bechstein, Susanna Hegewisch-Becker, Götz von Wichert, Matthias Vöhringer, Michael Heike, Volker Heinemann, Marc Peeters, Stephan Kanzler, Stefan Kasper, Friedrich Overkamp, Jan Schröder, Daniel Seehofer, Frank Kullmann, Bernhard Linz, Irene Schmidtmann, Victoria Smith-Machnow, Ines Gockel, Hauke Lang, Peter R Galle

Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics

Open Access
Research article

Armin Haupt, Gerard Joberty, Marcus Bantscheff, Holger Fröhlich, Henning Stehr, Michal R Schweiger, Axel Fischer, Martin Kerick, Stefan T Boerno, Andreas Dahl, Michael Lappe, Hans Lehrach, Cayetano Gonzalez, Gerard Drewes, Bodo MH Lange

Relevance of activated leukocyte cell adhesion molecule (ALCAM) in tumor tissue and sera of cervical cancer patients

Open Access
Research article

Maike Ihnen, Kerstin Kress, Jan Felix Kersten, Ergin Kilic, Matthias Choschzick, Hilke Zander, Volkmar Müller, Sven Mahner, Fritz Jänicke, Linn Woelber, Karin Milde-Langosch

Resection of the primary tumour versus no resection prior to systemic therapy in patients with colon cancer and synchronous unresectable metastases (UICC stage IV): SYNCHRONOUS - a randomised controlled multicentre trial (ISRCTN30964555)

Open Access
Study protocol

Nuh N Rahbari, Florian Lordick, Christine Fink, Ulrich Bork, Annika Stange, Dirk Jäger, Steffen P Luntz, Stefan Englert, Inga Rossion, Moritz Koch, Markus W Büchler, Meinhard Kieser, Jürgen Weitz

Androgen receptor expression predicts breast cancer survival: the role of genetic and epigenetic events

Open Access
Research article

Kate M Peters, Stacey L Edwards, Shalima S Nair, Juliet D French, Peter J Bailey, Kathryn Salkield, Sandra Stein, Sarah Wagner, Glenn D Francis, Susan J Clark, Melissa A Brown

REGγ is associated with multiple oncogenic pathways in human cancers

Open Access
Research article

Jing He, Long Cui, Yu Zeng, Guangqiang Wang, Ping Zhou, Yuanyuan Yang, Lei Ji, Yanyan Zhao, Jiwu Chen, Zhuo Wang, Tieliu Shi, Pei Zhang, Rui Chen, Xiaotao Li

Addition of bevacizumab to first-line chemotherapy in advanced colorectal cancer: a systematic review and meta-analysis, with emphasis on chemotherapy subgroups

Open Access
Research article

Ligia Traldi Macedo, Andre Bacellar da Costa Lima, Andre Deeke Sasse

Tri-Modality therapy with I-125 brachytherapy, external beam radiation therapy, and short- or long-term hormone therapy for high-risk localized prostate cancer (TRIP): study protocol for a phase III, multicenter, randomized, controlled trial

Open Access
Study protocol

Hiroyuki Konaka, Shin Egawa, Shiro Saito, Atsunori Yorozu, Hiroyuki Takahashi, Keiko Miyakoda, Masanori Fukushima, Takushi Dokiya, Hidetoshi Yamanaka, Nelson N Stone, Mikio Namiki

miRNA-135a promotes breast cancer cell migration and invasion by targeting HOXA10

Open Access
Research article

Yating Chen, Jin Zhang, Huijun Wang, Jiayi Zhao, Cheng Xu, Yingying Du, Xin Luo, Fengyun Zheng, Rui Liu, Hongwei Zhang, Duan Ma

Genetic polymorphisms in MMP 2, 9 and 3genes modify lung cancer risk and survival

Open Access
Research article

Patricia González-Arriaga, Teresa Pascual, Arturo García-Alvarez, Ana Fernández-Somoano, M Felicitas López-Cima, Adonina Tardón

Monitoring of patients treated with particle therapy using positron-emission-tomography (PET): the MIRANDA study

Open Access
Study protocol

Stephanie E Combs, Julia Bauer, Daniel Unholtz, Christopher Kurz, Thomas Welzel, Daniel Habermehl, Thomas Haberer, Jürgen Debus, Katia Parodi

Improving quality of breast cancer surgery through development of a national breast cancer surgical outcomes (BRCASO) research database

Open Access
Correspondence

Erin J Aiello Bowles, Heather Spencer Feigelson, Tom Barney, Katherine Broecker, Andrew Sterrett, Kimberly Bischoff, Jessica Engel, Gabrielle Gundersen, Johanna Sheehey-Jones, Richard Single, Adedayo Onitilo, Ted A James, Laurence E McCahill

Significant evidence for a heritable contribution to cancer predisposition: a review of cancer familiality by site

Open Access
Research article

Frederick Albright, Craig Teerlink, Theresa L Werner, Lisa A Cannon-Albright

HOXA1 is overexpressed in oral squamous cell carcinomas and its expression is correlated with poor prognosis

Open Access
Research article

Carolina Cavalcante Bitu, Maria Fernanda de Souza Setúbal Destro, Manoela Carrera, Sabrina Daniela da Silva, Edgard Graner, Luiz Paulo Kowalski, Fernando Augusto Soares, Ricardo D Coletta

Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line

Open Access
Research article

Sara R Martins-Neves, Áurio O Lopes, Anália do Carmo, Artur A Paiva, Paulo C Simões, Antero J Abrunhosa, Célia MF Gomes

Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines

Open Access
Research article

Ji Eun Kim, Clare Stones, Wayne R Joseph, Euphemia Leung, Graeme J Finlay, Andrew N Shelling, Wayne A Phillips, Peter R Shepherd, Bruce C Baguley

Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C

Open Access
Research article

Kyu Kwang Kim, Thilo S Lange, Rakesh K Singh, Laurent Brard, Richard G Moore

Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial

Open Access
Study protocol

Takuma Higurashi, Hirokazu Takahashi, Hiroki Endo, Kunihiro Hosono, Eiji Yamada, Hidenori Ohkubo, Eiji Sakai, Takashi Uchiyama, Yasuo Hata, Nobutaka Fujisawa, Shiori Uchiyama, Akiko Ezuka, Hajime Nagase, Takaomi Kessoku, Nobuyuki Matsuhashi, Shoji Yamanaka, Yoshiaki Inayama, Satoshi Morita, Atsushi Nakajima

PRAF3 induces apoptosis and inhibits migration and invasion in human esophageal squamous cell carcinoma

Open Access
Research article

Guo-Zhen Shi, Yang Yuan, Guo-Jun Jiang, Zhi-Jun Ge, Jian Zhou, De-Jun Gong, Jing Tao, Yong-Fei Tan, Sheng-Dong Huang

Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: A meta-analysis of clinical evidence

Open Access
Research article

Francis CH Ho, Ivan WK Tham, Arul Earnest, Khai Mun Lee, Jiade J Lu

Increased serum sTRAIL levels were correlated with survival in bevacizumab-treated metastatic colon cancer

Open Access
Research article

Atil Bisgin, Aysegul Kargi, Arzu D Yalcin, Cigdem Aydin, Deniz Ekinci, Burhan Savas, Salih Sanlioglu

Fibronectin matrix-mediated cohesion suppresses invasion of prostate cancer cells

Open Access
Research article

Dongxuan Jia, Ildiko Entersz, Christine Butler, Ramsey A Foty

The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure - one institution study

Open Access
Research article

Piotr Rutkowski, Elżbieta Bylina, Anna Klimczak, Tomasz Świtaj, Sławomir Falkowski, Jacek Kroc, Iwona Ługowska, Magdalena Brzeskwiniewicz, Wojciech Melerowicz, Czesław Osuch, Ewa Mierzejewska, Kacper Wasielewski, Agnieszka Woźniak, Urszula Grzesiakowska, Zbigniew I Nowecki, Janusz A Siedlecki, Janusz Limon

A pilot study of exercise in men with prostate cancer receiving androgen deprivation therapy

Open Access
Study protocol

C Ellen Lee, William D Leslie, YK James Lau

Differential pattern and prognostic significance of CD4+, FOXP3+ and IL-17+tumor infiltrating lymphocytes in ductal and lobular breast cancers

Open Access
Research article

Raoul Droeser, Inti Zlobec, Ergin Kilic, Uwe Güth, Michael Heberer, Giulio Spagnoli, Daniel Oertli, Coya Tapia

The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action

Open Access
Research article

Laurie Hamtiaux, Julien Masquelier, Giulio G Muccioli, Caroline Bouzin, Olivier Feron, Bernard Gallez, Didier M Lambert

Peritumoral vascular invasion and NHERF1 expression define an immunophenotype of grade 2 invasive breast cancer associated with poor prognosis

Open Access
Research article

Andrea Malfettone, Concetta Saponaro, Angelo Paradiso, Giovanni Simone, Annita Mangia

Methylation profiling of Epstein-Barr virus immediate-early gene promoters, BZLF1 and BRLF1in tumors of epithelial, NK- and B-cell origins

Open Access
Research article

Lili Li, Xianwei Su, Gigi Ching Gee Choi, Ya Cao, Richard F Ambinder, Qian Tao

Survival of endometrial cancer patients in Germany in the early 21st century: a period analysis by age, histology, and stage

Open Access
Research article

Tianhui Chen, Lina Jansen, Adam Gondos, Meike Ressing, Bernd Holleczek, Alexander Katalinic, Hermann Brenner

Survival of gastrointestinal stromal tumor patients in the imatinib era: life raft group observational registry

Open Access
Research article

Jerry Call, Christopher D Walentas, Jens C Eickhoff, Norman Scherzer

Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors

Open Access
Research article

Gargi Ghosh, Xiaojun Lian, Stephen J Kron, Sean P Palecek

Synthetic Lethal Screen Identifies NF-κB as a Target for Combination Therapy with Topotecan for patients with Neuroblastoma

Open Access
Research article

Patricia S Tsang, Adam T Cheuk, Qing-Rong Chen, Young K Song, Thomas C Badgett, Jun S Wei, Javed Khan

Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?

Open Access
Research article

Matias E Valsecchi, Thomas Holdbrook, Benjamin E Leiby, Edward Pequignot, Susan J Littman, Charles J Yeo, Jonathan R Brody, Agnieszka K Witkiewicz

Mesenchymal and stemness circulating tumor cells in early breast cancer diagnosis

Open Access
Research article

Guislaine Barrière, Alain Riouallon, Joël Renaudie, Michel Tartary, Michel Rigaud

Prognostic impact of mRNA levels of osteopontin splice variants in soft tissue sarcoma patients

Open Access
Research article

Antje Hahnel, Henri Wichmann, Thomas Greither, Matthias Kappler, Peter Würl, Matthias Kotzsch, Helge Taubert, Dirk Vordermark, Matthias Bache

A phase II study for metabolic in vivo response monitoring with sequential 18FDG-PET-CT during treatment with the EGFR-monoclonal-antibody cetuximab in metastatic colorectal cancer: the Heidelberg REMOTUX trial

Open Access
Study protocol

Anne Katrin Berger, Carl von Gall, Ulrich Abel, Stefan Delorme, Matthias Kloor, Jennifer Ose, Tim Frederik Weber, Annika Stange, Georg Martin Haag, Uwe Haberkorn, Florian Lordick, Dirk Jäger

Characterization of colon cancer cells: a functional approach characterizing CD133 as a potential stem cell marker

Open Access
Research article

Meike Schneider, Johannes Huber, Boris Hadaschik, Gabrielle M Siegers, Heinz-Herbert Fiebig, Julia Schüler

Esthesioneuroblastoma in pediatric and adolescent age. A report from the TREP project in cooperation with the Italian Neuroblastoma and Soft Tissue Sarcoma Committees

Open Access
Research article

Gianni Bisogno, Pietro Soloni, Massimo Conte, Marta Podda, Andrea Ferrari, Alberto Garaventa, Roberto Luksch, Giovanni Cecchetto

Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells

Open Access
Research article

Hannah Mak, Alexandra Naba, Sonal Varma, Colleen Schick, Andrew Day, Sandip K SenGupta, Monique Arpin, Bruce E Elliott

TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients

Open Access
Research article

Christian Körner, Katarina Riesner, Benjamin Krämer, Marianne Eisenhardt, Andreas Glässner, Franziska Wolter, Thomas Berg, Tobias Müller, Tilman Sauerbruch, Jacob Nattermann, Ulrich Spengler, Hans Dieter Nischalke

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells

Open Access
Research article

Martin Laschak, Klaus-Dieter Spindler, Andres J Schrader, Andrea Hessenauer, Wolfgang Streicher, Mark Schrader, Marcus V Cronauer

Serial selection for invasiveness increases expression of miR-143/miR-145 in glioblastoma cell lines

Open Access
Research article

Sunwoo Koo, Gail S Martin, Kevin J Schulz, Matthew Ronck, L Gerard Toussaint

Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy

Open Access
Research article

Carlos D Gamarra-Luques, Alicia A Goyeneche, Maria B Hapon, Carlos M Telleria

Isolation and genomic analysis of circulating tumor cells from castration resistant metastatic prostate cancer

Open Access
Technical advance

Mark Jesus M Magbanua, Eduardo V Sosa, Janet H Scott, Jeff Simko, Colin Collins, Dan Pinkel, Charles J Ryan, John W Park

Interleukin-10-819 promoter polymorphism in association with gastric cancer risk

Open Access
Research article

Huiping Xue, Bing Lin, Jianfu An, Yuyuan Zhu, Gang Huang

SULT1A1 rs9282861 polymorphism-a potential modifier of efficacy of the systemic adjuvant therapy in breast cancer?

Open Access
Research article

Maria Tengström, Arto Mannermaa, Veli-Matti Kosma, Ari Hirvonen, Vesa Kataja

Cancer incidence and mortality trends in Australian adolescents and young adults, 1982–2007

Open Access
Research article

Fatima A Haggar, David B Preen, Gavin Pereira, Cashel DJ Holman, Kristjana Einarsdottir

Adeno-associated virus-mediated doxycycline-regulatable TRAIL expression suppresses growth of human breast carcinoma in nude mice

Open Access
Research article

Liu Zheng, Zhang Weilun, Jiang Minghong, Zhang Yaxi, Liu Shilian, Liu Yanxin, Zheng Dexian

Inhibitory effect of Bifidobacterium infantis-mediated sKDR prokaryotic expression system on angiogenesis and growth of Lewis lung cancer in mice

Open Access
Research article

Zhao-Jun Li, Hong Zhu, Bu-Yun Ma, Fen Zhao, Shu-Hua Mao, Tai-Guo Liu, Jian-Ping He, Li-Cong Deng, Cheng Yi, Ying Huang

Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and jnk activation

Open Access
Research article

Cristina Trejo-Solís, Dolores Jimenez-Farfan, Sara Rodriguez-Enriquez, Francisca Fernandez-Valverde, Arturo Cruz-Salgado, Lena Ruiz-Azuara, Julio Sotelo

Adjuvant chemotherapy of pT1a and pT1b breast carcinoma: results from the NEMESI study

Open Access
Research article

Stefania Gori, Matteo Clavarezza, Salvatore Siena, Jennifer Foglietta, Emiliana Tarenzi, Monica Giordano, Annamaria Molino, Claudio Graiff, Vittorio Fusco, Oscar Alabiso, Editta Baldini, Teresa Gamucci, Giuseppe Altavilla, Davide Dondi, Marco Venturini

The prevalence and role of human papillomavirus genotypes in primary cervical screening in the northeast of China

Open Access
Research article

Shizhuo Wang, Heng Wei, Ning Wang, Shulan Zhang, Yao Zhang, Qiang Ruan, Weiguo Jiang, Qian Xiao, Xiaomei Luan, Xiuyan Qian, Lili Zhang, Xiang Gao, Xiaowei Sun

Customized chemotherapy based on epidermal growth factor receptormutation status for elderly patients with advanced non-small-cell lung cancer: a phase II trial

Open Access
Research article

Shiro Fujita, Nobuyuki Katakami, Katsuhiro Masago, Hiroshige Yoshioka, Keisuke Tomii, Toshihiko Kaneda, Masataka Hirabayashi, Kei Kunimasa, Toshio Morizane, Tadashi Mio

Imatinib-induced liver cirrhosis in a patient with advanced gastrointestinal stroma tumor (GIST)

Open Access
Case report

Christoph Seidel, Martin Fenner, Florian Länger, Heike Bantel, Arnold Ganser, Viktor Grünwald

ERCC1 as a biomarker for bladder cancer patients likely to benefit from adjuvant chemotherapy

Open Access
Research article

Jong-Mu Sun, Ji-Youn Sung, Se Hoon Park, Ghee Young Kwon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Jisuk Jo, Han Yong Choi, Ho Yeong Lim

A retrospective study of neoadjuvant FOLFIRINOX in unresectable or borderline-resectable locally advanced pancreatic adenocarcinoma

Open Access
Research article

Peter J Hosein, Jessica Macintyre, Carolina Kawamura, Jennifer Cudris Maldonado, Vinicius Ernani, Arturo Loaiza-Bonilla, Govindarajan Narayanan, Afonso Ribeiro, Lorraine Portelance, Jaime R Merchan, Joe U Levi, Caio M Rocha-Lima

Detection of circulating tumor cells in blood of metastatic breast cancer patients using a combination of cytokeratin and EpCAM antibodies

Open Access
Technical advance

Ulrike Weissenstein, Agnes Schumann, Marcus Reif, Susanne Link, Ulrike D Toffol-Schmidt, Peter Heusser

MGMT, GATA6, CD81, DR4, and CASP8 gene promoter methylation in glioblastoma

Open Access
Research article

Daina Skiriute, Paulina Vaitkiene, Viktoras Saferis, Virginija Asmoniene, Kestutis Skauminas, Vytenis Pranas Deltuva, Arimantas Tamasauskas

Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16

Open Access
Research article

Daniel Weiss, Mario Koopmann, Türker Basel, Claudia Rudack

Plant HDAC inhibitor chrysin arrest cell growth and induce p21 WAF1 by altering chromatin of STAT response element in A375 cells

Open Access
Research article

Manika Pal-Bhadra, M Janaki Ramaiah, T Lakshminarayan Reddy, Anita Krishnan, SNCVL Pushpavalli, K Suresh Babu, Ashok K Tiwari, J Madhusudana Rao, Jhillu S Yadav, Utpal Bhadra

Clinical significance of erythropoietin receptor expression in oral squamous cell carcinoma

Open Access
Research article

Yu-Tsai Lin, Hui-Ching Chuang, Chang-Han Chen, Gian Luca Armas, Han-Ku Chen, Fu-Min Fang, Chao-Cheng Huang, Chih-Yen Chien

Total and individual antioxidant intake and risk of epithelial ovarian cancer

Open Access
Research article

Dina Gifkins, Sara H Olson, Lisa Paddock, Melony King, Kitaw Demissie, Shou-En Lu, Ah-Ng Tony Kong, Lorna Rodriguez-Rodriguez, Elisa V Bandera

Unilateral follicular variant of papillary thyroid carcinoma with unique KRAS mutation in struma ovarii in bilateral ovarian teratoma: a rare case report

Open Access
Case report

Boban Stanojevic, Radan Dzodic, Vladimir Saenko, Zorka Milovanovic, Vesna Krstevski, Petar Radlovic, Marko Buta, Bozidar Rulic, Lidija Todorovic, Bogomir Dimitrijevic, Shunichi Yamashita

The role of cytochrome c oxidase subunit Va in non-small cell lung carcinoma cells: association with migration, invasion and prediction of distant metastasis

Open Access
Research article

Wen-Liang Chen, Kuang-Tai Kuo, Teh-Ying Chou, Chien-Lung Chen, Chih-Hao Wang, Yau-Huei Wei, Liang-Shun Wang

IMRT and carbon ion boost for malignant salivary gland tumors: interim analysis of the COSMIC trial

Open Access
Research article

Alexandra D Jensen, Anna V Nikoghosyan, Karen Lossner, Klaus K Herfarth, Jürgen Debus, Marc W Münter

Cervical cancer screening and adherence to follow-up among Hispanic women study protocol: a randomized controlled trial to increase the uptake of cervical cancer screening in Hispanic women

Open Access
Study protocol

Catherine Duggan, Gloria Coronado, Javiera Martinez, Theresa L Byrd, Elizabeth Carosso, Cathy Lopez, Maria Benavides, Beti Thompson

The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells

Open Access
Research article

Dongming Liang, Yuanyuan Ma, Jian Liu, Claes Goran Trope, Ruth Holm, Jahn M Nesland, Zhenhe Suo

NF-κB2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors

Open Access
Research article

Brian A McCarthy, Liqun Yang, Jane Ding, Mingqiang Ren, William King, Mohammed ElSalanty, Ibrahim Zakhary, Mohamed Sharawy, Hongjuan Cui, Han-Fei Ding

Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib

Open Access
Research article

Rama H Grantab, Ian F Tannock

Experimental in vivo and in vitro treatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer

Open Access
Research article

Dmitriy I Dovzhanskiy, Stefanie M Arnold, Thilo Hackert, Ina Oehme, Olaf Witt, Klaus Felix, Nathalia Giese, Jens Werner

The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein

Open Access
Research article

Joel D Pearson, Zubair Mohammed, Julinor T C Bacani, Raymond Lai, Robert J Ingham

Development of coronary artery stenosis in a patient with metastatic renal cell carcinoma treated with sorafenib

Open Access
Case report

Maria Abbondanza Pantaleo, Anna Mandrioli, Maristella Saponara, Margherita Nannini, Giovanna Erente, Cristian Lolli, Guido Biasco

The application of nonsense-mediated mRNA decay inhibition to the identification of breast cancer susceptibility genes

Open Access
Research article

Julie K Johnson, Nic Waddell, Georgia Chenevix-Trench

Decreased survival among lung cancer patients with co-morbid tuberculosis and diabetes

Open Access
Research article

Shwn-Huey Shieh, Janice C Probst, Fung-Chang Sung, Wen-Chen Tsai, Ya-Shin Li, Chih-Yi Chen

Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer

Open Access
Research article

Nam P Nguyen, Paul Vos, Vincent Vinh-Hung, Misty Ceizyk, Lexie Smith-Raymond, Michelle Stevie, Benjamin Slane, Alexander Chi, Anand Desai, Shane P Krafft, Siyoung Jang, Russ Hamilton, Ulf Karlsson, Dave Abraham

Generation of a new bioluminescent model for visualisation of mammary tumour development in transgenic mice

Open Access
Technical advance

Agnieszka M Zagozdzon, Patrick O’Leary, John J Callanan, John Crown, William M Gallagher, Radoslaw Zagozdzon

Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary

Open Access
Research article

Sarah Douglas, Stefan Huttenlocher, Amira Bajrovic, Volker Rudat, Steven E Schild, Dirk Rades

The efficacy of TACE combined sorafenib in advanced stages hepatocellullar carcinoma

Open Access
Research article

Xu-Dong Qu, Cheng-Shi Chen, Jian-Hua Wang, Zhi-ping Yan, Jie-min Chen, Gao-quan Gong, Qin-xin Liu, Jian-jun Luo, Lin-xiao Liu, Rong Liu, Sheng Qian

Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis

Open Access
Research article

Yanming Zhou, Yanfang Zhao, Bin Li, Jiyi Huang, Lupeng Wu, Donghui Xu, Jiamei Yang, Jia He

ZIC1 modulates cell-cycle distributions and cell migration through regulation of sonic hedgehog, PI3K and MAPK signaling pathways in gastric cancer

Open Access
Research article

Jing Zhong, Shujie Chen, Meng Xue, Qin Du, Jianting Cai, Hongchuan Jin, Jianmin Si, Liangjing Wang

Tumor stromal vascular endothelial growth factor A is predictive of poor outcome in inflammatory breast cancer

Open Access
Research article

Hugo Arias-Pulido, Nabila Chaher, Yun Gong, Clifford Qualls, Jake Vargas, Melanie Royce

The functional and structural characterization of a novel oncogene GIG47 involved in the breast tumorigenesis

Open Access
Research article

Kyou-Hoon Han, Si-Hyung Lee, Seon-Ah Ha, Hyun Kee Kim, CheWook Lee, Do-Hyoung Kim, Kee Hwan Gong, JinAh Yoo, Sanghee Kim, Jin Woo Kim

A validated survival score for patients with metastatic spinal cord compression from non-small cell lung cancer

Open Access
Research article

Dirk Rades, Sarah Douglas, Theo Veninga, Steven E Schild

Differential expression of cancer associated proteins in breast milk based on age at first full term pregnancy

Open Access
Research article

Wenyi Qin, Ke Zhang, Beth Kliethermes, Rachel L Ruhlen, Eva P Browne, Kathleen F Arcaro, Edward R Sauter

Clinical features and outcome of multiple primary malignancies involving hepatocellular carcinoma: A long-term follow-up study

Open Access
Research article

Qing-An Zeng, Jiliang Qiu, Ruhai Zou, Yijie Li, Shengping Li, Binkui Li, Pinzhu Huang, Jian Hong, Yun Zheng, Xiangming Lao, Yunfei Yuan

The association between general practitioners’ attitudes towards breast cancer screening and women’s screening participation

Open Access
Research article

Line Flytkjær Jensen, Thomas Ostersen Mukai, Berit Andersen, Peter Vedsted

Regulation of interferon pathway in 2-methoxyestradiol-treated osteosarcoma cells

Open Access
Research article

Fritz Wimbauer, Caihong Yang, Kristen L Shogren, Minzhi Zhang, Ribu Goyal, Scott M Riester, Michael J Yaszemski, Avudaiappan Maran

CT-Screening for lung cancer does not increase the use of anxiolytic or antidepressant medication

Open Access
Research article

Linda Kaerlev, Maria Iachina, Jesper Holst Pedersen, Anders Green, Bente Mertz Nørgård

Nuclear translocation of the cytoplasmic domain of HB-EGF induces gastric cancer invasion

Open Access
Research article

Takaya Shimura, Michihiro Yoshida, Shinji Fukuda, Masahide Ebi, Yoshikazu Hirata, Tsutomu Mizoshita, Satoshi Tanida, Hiromi Kataoka, Takeshi Kamiya, Shigeki Higashiyama, Takashi Joh

Estimation of groin recurrence risk in patients with squamous cell vulvar carcinoma by the assessment of marker gene expression in the lymph nodes

Open Access
Research article

Magdalena Kowalewska, Jakub Radziszewski, Krzysztof Goryca, Mateusz Bujko, Malgorzata Oczko-Wojciechowska, Michal Jarzab, Janusz Aleksander Siedlecki, Mariusz Bidzinski

Aggressive local treatment containing intraoperative radiation therapy (IORT) for patients with isolated local recurrences of pancreatic cancer: a retrospective analysis

Open Access
Research article

Falk Roeder, Carmen Timke, Matthias Uhl, Gregor Habl, Frank W Hensley, Markus W Buechler, Robert Krempien, Peter E Huber, Juergen Debus, Jens Werner

The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients

Open Access
Research article

Catharina Medrek, Fredrik Pontén, Karin Jirström, Karin Leandersson

Implementation and scientific evaluation of rehabilitative sports groups for prostate cancer patients: study protocol of the ProRehab Study

Open Access
Study protocol

Eva M Zopf, Moritz Braun, Stefan Machtens, Jürgen Zumbé, Wilhelm Bloch, Freerk T Baumann

Risk of second breast cancer in female Hodgkin’s lymphoma survivors: a meta-analysis

Open Access
Research article

Ezzeldin M Ibrahim, Khaled M Abouelkhair, Ghieth A Kazkaz, Osama A Elmasri, Meteb Al-Foheidi

Antitumor activity of zoledronic acid in primary breast cancer cells determined by the ATP tumor chemosensitivity assay

Open Access
Research article

Tanja Fehm, Manfred Zwirner, Diethelm Wallwiener, Harald Seeger, Hans Neubauer

Physiological and neurophysiological determinants of postcancer fatigue: design of a randomized controlled trial

Open Access
Study protocol

Hetty Prinsen, Gijs Bleijenberg, Machiel J Zwarts, Maria T E Hopman, Arend Heerschap, Hanneke W M van Laarhoven

Early assessment by FDG-PET/CT of patients with advanced renal cell carcinoma treated with tyrosine kinase inhibitors is predictive of disease course

Open Access
Research article

Daiki Ueno, Masahiro Yao, Ukihide Tateishi, Ryogo Minamimoto, Kazuhide Makiyama, Narihiko Hayashi, Futoshi Sano, Takayuki Murakami, Takeshi Kishida, Takeshi Miura, Kazuki Kobayashi, Sumio Noguchi, Ichiro Ikeda, Yoshiharu Ohgo, Tomio Inoue, Yoshinobu Kubota, Noboru Nakaigawa

Constitutively active c-Met kinase in PC-3 cells is autocrine-independent and can be blocked by the Met kinase inhibitor BMS-777607

Open Access
Research article

Yao Dai, Dietmar W Siemann

A randomised controlled trial of a cognitive behavioural intervention for men who have hot flushes following prostate cancer treatment (MANCAN): trial protocol

Open Access
Study protocol

Omar Yousaf, Evgenia Stefanopoulou, Elizabeth A Grunfeld, Myra S Hunter

Myeloid malignancies: mutations, models and management

Open Access
Review

Anne Murati, Mandy Brecqueville, Raynier Devillier, Marie-Joelle Mozziconacci, Véronique Gelsi-Boyer, Daniel Birnbaum

Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest

Open Access
Research article

Fumihiko Uchida, Katsuhiro Uzawa, Atsushi Kasamatsu, Hiroaki Takatori, Yosuke Sakamoto, Katsunori Ogawara, Masashi Shiiba, Hideki Tanzawa, Hiroki Bukawa

Design of the study: How can health care help female breast cancer patients reduce their stress symptoms? A randomized intervention study with stepped-care

Open Access
Study protocol

Karin Nordin, Ritva Rissanen, Johan Ahlgren, Gunilla Burell, Marie-Louise Fjällskog, Susanne Börjesson, Cecilia Arving

Oxidative DNA damage correlates with cell immortalization and mir-92 expression in hepatocellular carcinoma

Open Access
Research article

Cardin Romilda, Piciocchi Marika, Sinigaglia Alessandro, Lavezzo Enrico, Bortolami Marina, Kotsafti Andromachi, Cillo Umberto, Zanus Giacomo, Mescoli Claudia, Rugge Massimo, Farinati Fabio

Glutathione S-transferase Pi expression predicts response to adjuvant chemotherapy for stage C colon cancer: a matched historical control study

Open Access
Research article

Lucy Jankova, Graham Robertson, Charles Chan, King L Tan, Maija Kohonen-Corish, Caroline L-S Fung, Candice Clarke, Betty P C Lin, Mark Molloy, Pierre H Chapuis, Les Bokey, Owen F Dent, Stephen J Clarke

Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors

Open Access
Research article

Chia-Lin Hsu, Kuan-Yu Chen, Jin-Yuan Shih, Chao-Chi Ho, Chih-Hsin Yang, Chong-Jen Yu, Pan-Chyr Yang

Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer

Open Access
Research article

Line L Haugan Moi, Marianne Hauglid Flågeng, Jennifer Gjerde, Andre Madsen, Therese Halvorsen Røst, Oddrun Anita Gudbrandsen, Ernst A Lien, Gunnar Mellgren

Atypical primary meningioma in the nasal septum with malignant transformation and distant metastasis

Open Access
Case report

Byoung Joon Baek, Jae–Min Shin, Chi Kyou Lee, Ji Hye Lee, Koen Hyeong Lee

Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol

Open Access
Study protocol

Karsten Geletneky, Johannes Huesing, Jean Rommelaere, Joerg R Schlehofer, Barbara Leuchs, Michael Dahm, Ottheinz Krebs, Magnus von Knebel Doeberitz, Bernard Huber, Jacek Hajda

Prevalence and correlates of cancer survivors’ supportive care needs 6 months after diagnosis: a population-based cross-sectional study

Open Access
Research article

Allison W Boyes, Afaf Girgis, Catherine D’Este, Alison C Zucca

Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck

Open Access
Research article

Ziyuan Zhou, Erich M Sturgis, Zhensheng Liu, Li-E Wang, Qingyi Wei, Guojun Li

Immunophenotyping invasive breast cancer: paving the road for molecular imaging

Open Access
Research article

Jeroen F Vermeulen, Aram SA van Brussel, Petra van der Groep, Folkert HM Morsink, Peter Bult, Elsken van der Wall, Paul J van Diest

Biological characterization and selection criteria of adjuvant chemotherapy for early breast cancer: experience from the Italian observational NEMESI study

Open Access
Research article

Matteo Clavarezza, Giorgio Mustacchi, Andrea Casadei Gardini, Lucia Del Mastro, Andrea De Matteis, Ferdinando Riccardi, Vincenzo Adamo, Enrico Aitini, Domenico Amoroso, Paolo Marchetti, Stefania Gori, Francesco Carrozza, Evaristo Maiello, Francesco Giotta, Davide Dondi, Marco Venturini

Menin and p53 have non-synergistic effects on tumorigenesis in mice

Open Access
Research article

Kelly A Loffler, Arne W Mould, Paul M Waring, Nicholas K Hayward, Graham F Kay

Stereotactic ablative radiotherapy for comprehensive treatment of oligometastatic tumors (SABR-COMET): Study protocol for a randomized phase II trial

Open Access
Study protocol

David A Palma, Cornelis J A Haasbeek, George B Rodrigues, Max Dahele, Michael Lock, Brian Yaremko, Robert Olson, Mitchell Liu, Jason Panarotto, GwendolynHMJ Griffioen, Stewart Gaede, Ben Slotman, Suresh Senan

Survival in patients with stage IV noncardia gastric cancer - the influence of DNA ploidy and Helicobacter Pyloriinfection

Open Access
Research article

John Syrios, Stavros Sougioultzis, Ioannis D Xynos, Nikolaos Kavantzas, Christos Kosmas, George Agrogiannis, John Griniatsos, Ioannis Karavokyros, Emmanouil Pikoulis, Efstratios S Patsouris, Nikolas Tsavaris

Hornerin, an S100 family protein, is functional in breast cells and aberrantly expressed in breast cancer

Open Access
Research article

Jodie M Fleming, Erika Ginsburg, Shannon D Oliver, Paul Goldsmith, Barbara K Vonderhaar

Prospective evaluation of quality of life effects in patients undergoing palliative radiotherapy for brain metastases

Open Access
Research article

Diana Steinmann, Yvonne Paelecke-Habermann, Hans Geinitz, Raimund Aschoff, Anja Bayerl, Tobias Bölling, Elisabeth Bosch, Frank Bruns, Ute Eichenseder-Seiss, Johanna Gerstein, Nadine Gharbi, Juliane Hagg, Matthias Hipp, Irmgard Kleff, Axel Müller, Christof Schäfer, Ursula Schleicher, Susanne Sehlen, Marilena Theodorou, Hans-Joachim Wypior, Franz Zehentmayr, Birgitt van Oorschot, Dirk Vordermark

Methylation signature of lymph node metastases in breast cancer patients

Open Access
Research article

Zeinab Barekati, Ramin Radpour, Qing Lu, Johannes Bitzer, Hong Zheng, Paolo Toniolo, Per Lenner, Xiao Yan Zhong

Circulating endothelial cells and other angiogenesis factors in pancreatic carcinoma patients receiving gemcitabine chemotherapy

Open Access
Research article

Shunsuke Kondo, Hideki Ueno, Jun Hashimoto, Chigusa Morizane, Fumiaki Koizumi, Takuji Okusaka, Kenji Tamura

Small-area analyses of bone cancer diagnosed in Great Britain provide clues to aetiology

Open Access
Research article

Richard J Q McNally, Karen Blakey, Roger C Parslow, Peter W James, Basilio Gómez Pozo, Charles Stiller, Tim J Vincent, Paul Norman, Patricia A McKinney, Michael F Murphy, Alan W Craft, Richard G Feltbower

Combination chemotherapy with intermittent erlotinib and pemetrexed for pretreated patients with advanced non-small cell lung cancer: a phase I dose-finding study

Open Access
Research article

Seigo Minami, Takashi Kijima, Ryo Takahashi, Hiroshi Kida, Takeshi Nakatani, Masanari Hamaguchi, Yoshiko Takeuchi, Izumi Nagatomo, Suguru Yamamoto, Isao Tachibana, Kiyoshi Komuta, Ichiro Kawase

Snail transcription factor negatively regulates maspin tumor suppressor in human prostate cancer cells

Open Access
Research article

Corey L Neal, Veronica Henderson, Bethany N Smith, Danielle McKeithen, Tisheeka Graham, Baohan T Vo, Valerie A Odero-Marah

Expression of Bim, Noxa, and Puma in non-small cell lung cancer

Open Access
Research article

Jun Sakakibara-Konishi, Satoshi Oizumi, Junko Kikuchi, Eiki Kikuchi, Hidenori Mizugaki, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, Masaharu Nishimura

ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways

Open Access
Research article

Guohui Wang, Gang Liu, Xiaogang Wang, Seema Sethi, Rouba Ali-Fehmi, Judith Abrams, Ze Zheng, Kezhong Zhang, Stephen Ethier, Zeng-Quan Yang

EnROL: A multicentre randomised trial of conventional versus laparoscopic surgery for colorectal cancer within an enhanced recovery programme

Open Access
Study protocol

Robin H Kennedy, Anne Francis, Susan Dutton, Sharon Love, Sarah Pearson, Jane M Blazeby, Philip Quirke, Peter J Franks, David J Kerr

Weekly paclitaxel plus trastuzumab in metastatic breast cancer pretreated with anthracyclines-a phase II multipractice study

Open Access
Research article

Matthias John, Axel Hinke, Martina Stauch, Heiner Wolf, Benno Mohr, Hans-Joachim Hindenburg, Jens Papke, Joachim Schlosser

Persistent tumor cells in bone marrow of non-metastatic breast cancer patients after primary surgery are associated with inferior outcome

Open Access
Research article

Kjersti Tjensvoll, Satu Oltedal, Reino Heikkilä, Jan Terje Kvaløy, Bjørnar Gilje, James M Reuben, Rune Smaaland, Oddmund Nordgård

Role of plasma EBV DNA levels in predicting recurrence of nasopharyngeal carcinoma in a western population

Open Access
Research article

Daris Ferrari, Carla Codecà, Cecilia Bertuzzi, Francesca Broggio, Francesca Crepaldi, Andrea Luciani, Irene Floriani, Mohssen Ansarin, Fausto Chiesa, Daniela Alterio, Paolo Foa

Expression of proto-oncogene KIT is up-regulated in subset of human meningiomas

Open Access
Research article

Masum Saini, Ajaya Nand Jha, Andleeb Abrari, Sher Ali

Does risk for ovarian malignancy algorithm excel human epididymis protein 4 and ca125 in predicting epithelial ovarian cancer: A meta-analysis

Open Access
Research article

Fake Li, Ruxiu Tie, Kai Chang, Feng Wang, Shaoli Deng, Weiping Lu, Lili Yu, Ming Chen

Do Couple-Based Interventions Make a Difference for Couples Affected by Cancer?: A Systematic Review

Open Access
Research article

Tim W Regan, Sylvie D Lambert, Afaf Girgis, Brian Kelly, Karen Kayser, Jane Turner

Is there a role for consolidative radiotherapy in the treatment of aggressive and localized Non-Hodgkin Lymphoma? A systematic review with meta-analysis

Open Access
Research article

Lucas Vieira dos Santos, JoãoPaulodaSilveiraNogueira Lima, Carmens Sílvia Passos Lima, Emma Chen Sasse, André Deeke Sasse

The development of a supportive care needs assessment tool for Indigenous people with cancer

Open Access
Research article

Gail Garvey, Vanessa L Beesley, Monika Janda, Catherine Jacka, Adèle C Green, Peter O’Rourke, Patricia C Valery

Nutrition deficiency increases the risk of stomach cancer mortality

Open Access
Research article

Qing Da Li, Hao Li, Fu Ji Li, Mei Shu Wang, Zhuo Jian Li, Jing Han, Qing Hui Li, Xiang Ji Ma, Da Nan Wang

Is there a role of whole-body bone scan in patients with esophageal squamous cell carcinoma

Open Access
Research article

Shau-Hsuan Li, Yung-Cheng Huang, Wan-Ting Huang, Wei-Che Lin, Chien-Ting Liu, Wan-Yu Tien, Hung-I Lu

Conspicuity of breast lesions at different b values on diffusion-weighted imaging

Open Access
Research article

Xin Chen, Xi-Jing He, Rui Jin, You-Min Guo, Xian Zhao, Hua-Feng Kang, Li-Ping Mo, Qian Wu

Health-related quality of life among colorectal cancer patients in Malaysia: a study protocol

Open Access
Study protocol

Bello Arkilla Magaji, Foong Ming Moy, April Camilla Roslani, Ismail Sagap, Jasiah Zakaria, Jane M Blazeby, Chee Wei Law

Body mass index and survival after breast cancer diagnosis in Japanese women

Open Access
Research article

Masaaki Kawai, Yuko Minami, Yoshikazu Nishino, Kayoko Fukamachi, Noriaki Ohuchi, Yoichiro Kakugawa

Estimates of cancer incidence, mortality and survival in aboriginal people from NSW, Australia

Open Access
Research article

Stephen Morrell, Hui You, Deborah Baker

Effect of KRAS codon13 mutations in patients with advanced colorectal cancer (advanced CRC) under oxaliplatin containing chemotherapy. Results from a translational study of the AIO colorectal study group

Open Access
Research article

Anke Reinacher-Schick, Karsten Schulmann, Dominik P Modest, Nina Bruns, Ulrich Graeven, Malgorzata Jaworska, Richard Greil, Rainer Porschen, Dirk Arnold, Wolff Schmiegel, Andrea Tannapfel

Longitudinal MRI contrast enhanced monitoring of early tumour development with manganese chloride (MnCl2) and superparamagnetic iron oxide nanoparticles (SPIOs) in a CT1258 based in vivo model of prostate cancer

Open Access
Research article

Katharina A Sterenczak, Martin Meier, Silke Glage, Matthias Meyer, Saskia Willenbrock, Patrick Wefstaedt, Martina Dorsch, Jörn Bullerdiek, Hugo Murua Escobar, Hans Hedrich, Ingo Nolte

Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR–dependent motility in alveolar rhabdomyosarcoma cells

Open Access
Research article

Lingling Liu, Yong-Dong Wang, Jing Wu, Jimmy Cui, Taosheng Chen

Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures

Open Access
Research article

Yu-Ting Saw, Junzheng Yang, Shu-Kay Ng, Shubai Liu, Surendra Singh, Margit Singh, William R Welch, Hiroshi Tsuda, Wing-Ping Fong, David Thompson, Vasilis Vasiliou, Ross S Berkowitz, Shu-Wing Ng

Expression of S100A4, ephrin-A1 and osteopontin in non-small cell lung cancer

Open Access
Research article

Ane Kongsgaard, Marius Lund-Iversen, Gisle Berge, Odd Terje Brustugun, Steinar K Solberg, Gunhild M Mælandsmo, Kjetil Boye

Study protocol of the SACURA trial: a randomized phase III trial of efficacy and safety of UFT as adjuvant chemotherapy for stage II colon cancer

Open Access
Study protocol

Megumi Ishiguro, Hidetaka Mochizuki, Naohiro Tomita, Yasuhiro Shimada, Keiichi Takahashi, Kenjiro Kotake, Masahiko Watanabe, Yukihide Kanemitsu, Hideki Ueno, Toshiaki Ishikawa, Hiroyuki Uetake, Shigeyuki Matsui, Satoshi Teramukai, Kenichi Sugihara

Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: A randomized double-blind placebo controlled trial

Open Access
Research article

Zohreh Ghoreishi, Ali Esfahani, Abolghasem Djazayeri, Mahmoud Djalali, Banafsheh Golestan, Hormoz Ayromlou, Shahriar Hashemzade, Mohammad Asghari Jafarabadi, Vahid Montazeri, Seyed Ali Keshavarz, Masoud Darabi

DcR3 binds to ovarian cancer via heparan sulfate proteoglycans and modulates tumor cells response to platinum with corresponding alteration in the expression of BRCA1

Open Access
Research article

Joseph P Connor, Mildred Felder, Arvinder Kapur, Nonyem Onujiogu

The mitochondrial transporter SLC25A43 is frequently deleted and may influence cell proliferation in HER2-positive breast tumors

Open Access
Research article

Elisabet Tina, Breezy Malakkaran Lindqvist, Marike Gabrielson, Zelmina Lubovac, Pia Wegman, Sten Wingren

Real-imaging cDNA-AFLP transcript profiling of pancreatic cancer patients: Egr-1 as a potential key regulator of muscle cachexia

Open Access
Research article

Alexander Skorokhod, Jeannine Bachmann, Nathalia A Giese, Marc E Martignoni, Holger Krakowski-Roosen

XELIRI-bevacizumab versus FOLFIRI-bevacizumab as first-line treatment in patients with metastatic colorectal cancer: a Hellenic Cooperative Oncology Group phase III trial with collateral biomarker analysis

Open Access
Research article

Dimitrios Pectasides, George Papaxoinis, Konstantine T Kalogeras, Anastasia G Eleftheraki, Ioannis Xanthakis, Thomas Makatsoris, Epaminondas Samantas, Ioannis Varthalitis, Pavlos Papakostas, Nikitas Nikitas, Christos N Papandreou, George Pentheroudakis, Eleni Timotheadou, Angelos Koutras, Joseph Sgouros, Dimitrios Bafaloukos, George Klouvas, Theofanis Economopoulos, Konstantinos N Syrigos, George Fountzilas

Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition

Open Access
Research article

Sreenivasulu Chintala, Tanbir Najrana, Karoly Toth, Shousong Cao, Farukh A Durrani, Roberto Pili, Youcef M Rustum

Novel synergistic antitumor effects of rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor model

Open Access
Research article

Cun Wang, Dongmei Gao, Kun Guo, Xiaonan Kang, Kai Jiang, Chun Sun, Yan Li, Lu Sun, Hong Shu, Guangzhi Jin, Haiyan Sun, Weizhong Wu, Yinkun Liu

Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cells

Open Access
Research article

Cornel J Phillip, Christopher K Giardina, Birdal Bilir, David J Cutler, Yu-Heng Lai, Omer Kucuk, Carlos S Moreno

Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study

Open Access
Research article

Vibeke Andersen, Rikke Egeberg, Anne Tjønneland, Ulla Vogel

Promoter hypermethylation-induced transcriptional down-regulation of the gene MYCT1in laryngeal squamous cell carcinoma

Open Access
Research article

Min Yang, Wei Li, Yi-Ying Liu, Shuang Fu, Guang-Bin Qiu, Kai-Lai Sun, Wei-Neng Fu

Expression of human Piwi-likegenes is associated with prognosis for soft tissue sarcoma patients

Open Access
Research article

Thomas Greither, Franziska Koser, Matthias Kappler, Matthias Bache, Christine Lautenschläger, Steffen Göbel, Hans-Jürgen Holzhausen, Sven Wach, Peter Würl, Helge Taubert

Association of estrogen receptor betavariants and serum levels of estradiol with risk of colorectal cancer: a case control study

Open Access
Research article

Huanlei Wu, Li Xu, Jigui Chen, Junbo Hu, Shiying Yu, Guangyuan Hu, Liu Huang, Xiaoping Chen, Xianglin Yuan, Guojun Li

How should we discuss genetic testing with women newly diagnosed with breast cancer? Design and implementation of a randomized controlled trial of two models of delivering education about treatment-focused genetic testing to younger women newly diagnosed with breast cancer

Open Access
Study protocol

Kaaren J Watts, Bettina Meiser, Gillian Mitchell, Judy Kirk, Christobel Saunders, Michelle Peate, Jessica Duffy, Patrick J Kelly, Margaret Gleeson, Kristine Barlow-Stewart, Belinda Rahman, Michael Friedlander, Kathy Tucker

Additional diagnostic value of tumor markers in cytological fluid for diagnosis of non-small-cell lung cancer

Open Access
Research article

Jin Hur, Hye-Jeong Lee, Ji Eun Nam, Young Jin Kim, Yoo Jin Hong, Hee Yeong Kim, Se Kyu Kim, Joon Chang, Joo-Hang Kim, Kyung Young Chung, Hye Sun Lee, Byoung Wook Choi

Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells

Open Access
Research article

Anping Gui, Akira Kobayashi, Hiroaki Motoyama, Masato Kitazawa, Michiko Takeoka, Shinichi Miyagawa

Intraneural metastasis of gastric carcinoma leads to sciatic nerve palsy

Open Access
Case report

Jiro Ichikawa, Seiichi Matsumoto, Takashi Shimoji, Taisuke Tanizawa, Tabu Gokita, Keiko Hayakawa, Kaoru Aoki, Saori Ina, Hiroaki Kanda

Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer

Open Access
Research article

Biao Fan, Lian-Hai Zhang, Yong-ning Jia, Xi-Yao Zhong, Yi-Qiang Liu, Xiao-Jing Cheng, Xiao-Hong Wang, Xiao-Fang Xing, Ying Hu, Ying-Ai Li, Hong Du, Wei Zhao, Zhao-Jian Niu, Ai-Ping Lu, Ji-You Li, Jia-Fu Ji

For patients with breast cancer, geographic and social disparities are independent determinants of access to specialized surgeons. A eleven-year population-based multilevel analysis

Open Access
Research article

Julie Gentil, Tienhan Sandrine Dabakuyo, Samiratou Ouedraogo, Marie-Laure Poillot, Olivier Dejardin, Patrick Arveux

A randomized, phase 2 study comparing pemetrexed plus best supportive care versus best supportive care as maintenance therapy after first-line treatment with pemetrexed and cisplatin for advanced, non-squamous, non-small cell lung cancer

Open Access
Research article

Nabil Mubarak, Rabab Gaafar, Samir Shehata, Tarek Hashem, Dani Abigeres, Hamdy A Azim, Gamal El-Husseiny, Hamed Al-Husaini, Zhixin Liu

Detection of cervical lymph node metastasis in head and neck cancer patients with clinically N0 neck—a meta-analysis comparing different imaging modalities

Open Access
Research article

Li-Jen Liao, Wu-Chia Lo, Wan-Lun Hsu, Chi-Te Wang, Mei-Shu Lai

The influence of the combined treatment with Vadimezan (ASA404) and taxol on the growth of U251 glioblastoma xenografts

Open Access
Research article

Dušan Milanović, Friederike Braun, Wolfgang Weber, Anca Ligia Grosu, Martin Behe, Gabriele Niedermann

Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome

Open Access
Research article

Jia Xu, Priya B Shetty, Weiwei Feng, Carol Chenault, Robert C Bast Jr, Jean-Pierre J Issa, Susan G Hilsenbeck, Yinhua Yu

Ligand-free estrogen receptor activity complements IGF1R to induce the proliferation of the MCF-7 breast cancer cells

Open Access
Research article

Anne-Marie Gaben, Michèle Sabbah, Gérard Redeuilh, Monique Bedin, Jan Mester

The association between the preoperative serum levels of lipocalin-2 and matrix metalloproteinase-9 (MMP-9) and prognosis of breast cancer

Open Access
Research article

Hyuna Sung, Ji-Yeob Choi, Sang-Ah Lee, Kyoung-Mu Lee, Sohee Han, Sujee Jeon, Minkyo Song, Yunhee Lee, Sue K Park, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, Daehee Kang

MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells

Open Access
Research article

Lea H Gregersen, Anders Jacobsen, Lisa B Frankel, Jiayu Wen, Anders Krogh, Anders H Lund

Effect of inhibition of the Ubiquitin-Proteasome System and Hsp90 on growth and survival of Rhabdomyosarcoma cells in vitro

Open Access
Research article

Marica Peron, Paolo Bonvini, Angelo Rosolen

The role of TGFBI in mesothelioma and breast cancer: association with tumor suppression

Open Access
Research article

Bingyan Li, Gengyun Wen, Yongliang Zhao, Jian Tong, Tom K Hei

SOXs in human prostate cancer: implication as progression and prognosis factors

Open Access
Research article

Wei-de Zhong, Guo-qiang Qin, Qi-shan Dai, Zhao-dong Han, Shan-ming Chen, Xiao-hui Ling, Xin Fu, Chao Cai, Jia-hong Chen, Xi-bin Chen, Zhuo-yuan Lin, Ye-han Deng, Shu-lin Wu, Hui-chan He, Chin-lee Wu

Clinical outcomes of HER2-positive metastatic breast cancer patients with brain metastasis treated with lapatinib and capecitabine: an open-label expanded access study in Korea

Open Access
Research article

Jungsil Ro, Sohee Park, Sung- Bae Kim, Tae You Kim, Young Hyuk Im, Sun Young Rha, Joo Seop Chung, Hanlim Moon, Sergio Santillana

Low or undetectable TPO receptor expression in malignant tissue and cell lines derived from breast, lung, and ovarian tumors

Open Access
Research article

Connie L Erickson-Miller, Kodandaram Pillarisetti, Jennifer Kirchner, David J Figueroa, Lone Ottesen, Anne-Marie Martin, Yuan Liu, Yasser Mostafa Kamel, Conrad Messam

Association of postmenopausal endogenous sex hormones with global methylation level of leukocyte DNA among Japanese women

Open Access
Research article

Motoki Iwasaki, Hiroe Ono, Aya Kuchiba, Yoshio Kasuga, Shiro Yokoyama, Hiroshi Onuma, Hideki Nishimura, Ritsu Kusama, Teruhiko Yoshida, Shoichiro Tsugane

Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone

Open Access
Research article

Jolieke G van Oosterwijk, Danielle de Jong, Maayke AJH van Ruler, Pancras CW Hogendoorn, PD Sander Dijkstra, Carla SP van Rijswijk, Isidro Machado, Antonio Llombart-Bosch, Karoly Szuhai, Judith VMG Bovée

Common genetic polymorphisms of microRNA biogenesis pathway genes and breast cancer survival

Open Access
Research article

Hyuna Sung, Sujee Jeon, Kyoung-Mu Lee, Sohee Han, Minkyo Song, Ji-Yeob Choi, Sue K Park, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, Daehee Kang

Late onset Li-Fraumeni Syndrome with bilateral breast cancer and other malignancies: case report and review of the literature

Open Access
Case report

Karin Kast, Mechthild Krause, Markus Schuler, Katrin Friedrich, Barbara Thamm, Andrea Bier, Wolfgang Distler, Stefan Krüger

Ovarian metastases resection from extragenital primary sites: outcome and prognostic factor analysis of 147 patients

Open Access
Research article

Wenhua Li, Huaying Wang, Jian Wang, Fangfang LV, Xiaodong Zhu, Zhonghua Wang

Bax expression measured by AQUAnalysis is an independent prognostic marker in oral squamous cell carcinoma

Open Access
Research article

Pinaki Bose, Alexander C Klimowicz, Elizabeth Kornaga, Stephanie K Petrillo, T Wayne Matthews, Shamir Chandarana, Anthony M Magliocco, Nigel T Brockton, Joseph C Dort

An association between hOGG1Ser326Cys polymorphism and the risk of bladder cancer in non-smokers: a meta-analysis

Open Access
Research article

Changwei Ji, Zhao Liu, Huimei Chen, Hongqian Guo, Changjian Liu

C-reactive protein in patients with advanced metastatic renal cell carcinoma: Usefulness in identifying patients most likely to benefit from initial nephrectomy

Open Access
Research article

Hiroki Ito, Koichi Shioi, Takayuki Murakami, Akitoshi Takizawa, Futoshi Sano, Takashi Kawahara, Nobuhiko Mizuno, Kazuhide Makiyama, Noboru Nakaigawa, Takeshi Kishida, Takeshi Miura, Yoshinobu Kubota, Masahiro Yao

Inhibition of DNA methyltransferase activity and expression by treatment with the pan-deacetylase inhibitor panobinostat in hepatocellular carcinoma cell lines

Open Access
Research article

Steffen Zopf, Matthias Ocker, Daniel Neureiter, Beate Alinger, Susanne Gahr, Markus F Neurath, Pietro Di Fazio

Impact of Salinomycin on human cholangiocarcinoma: induction of apoptosis and impairment of tumor cell proliferation in vitro

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Research article

Thorsten Lieke, Wolf Ramackers, Sabine Bergmann, Jürgen Klempnauer, Michael Winkler, Johannes Klose

Reversible Posterior Leukoencephalopathy Syndrome Induced by Pazopanib

Open Access
Case report

Leonidas Chelis, Vasilios Souftas, Kiriakos Amarantidis, Nikolaos Xenidis, Eleni Chamalidou, Prokopios Dimopoulos, Prodromos Michailidis, Evagelos Christakidis, Panagiotis Prassopoulos, Stylianos Kakolyris

Effect of the pringle maneuver on tumor recurrence of hepatocellular carcinoma after curative resection (EPTRH): a randomized, prospective, controlled multicenter trial

Open Access
Study protocol

Feng Xiaobin, Zheng Shuguo, Zhou Jian, Qiu Yudong, Liang Lijian, Ma Kuansheng, Li Xiaowu, Xia Feng, Yi Dong, Wang Shuguang, Bie Ping, Dong Jiahong

Indirubin derivative E804 inhibits angiogenesis

Open Access
Research article

Eun-Kyung Shin, Jin-Kyung Kim

Vitamin D3receptor is highly expressed in Hodgkin’s lymphoma

Open Access
Research article

Christoph Renné, Alexander H Benz, Martin L Hansmann

The database of chromosome imbalance regions and genes resided in lung cancer from Asian and Caucasian identified by array-comparative genomic hybridization

Open Access
Research article

Fang-Yi Lo, Jer-Wei Chang, I-Shou Chang, Yann-Jang Chen, Han-Shui Hsu, Shiu-Feng Kathy Huang, Fang-Yu Tsai, Shih Sheng Jiang, Rajani Kanteti, Suvobroto Nandi, Ravi Salgia, Yi-Ching Wang

A randomized phase II trial to elucidate the efficacy of capecitabine plus cisplatin (XP) and S-1 plus cisplatin (SP) as a first-line treatment for advanced gastric cancer: XP ascertainment vs. SP randomized PII trial (XParTS II)

Open Access
Study protocol

Akira Tsuburaya, Satoshi Morita, Yasuhiro Kodera, Michiya Kobayashi, Kohei Shitara, Kensei Yamaguchi, Takaki Yoshikawa, Kazuhiro Yoshida, Shigefumi Yoshino, Jun-ichi Sakamoto

Ephrin-A1 inhibits NSCLC tumor growth via induction of Cdx-2 a tumor suppressor gene

Open Access
Research article

Bhagyalaxmi Sukka-Ganesh, Kamal A Mohammed, Frederic Kaye, Eugene P Goldberg, Najmunnisa Nasreen

Integrative genome-wide expression profiling identifies three distinct molecular subgroups of renal cell carcinoma with different patient outcome

Open Access
Research article

Manfred Beleut, Philip Zimmermann, Michael Baudis, Nicole Bruni, Peter Bühlmann, Oliver Laule, Van-Duc Luu, Wilhelm Gruissem, Peter Schraml, Holger Moch

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Open Access
Research article

Lina Y Dimberg, Anna Dimberg, Karolina Ivarsson, Mårten Fryknäs, Linda Rickardson, Gerard Tobin, Simon Ekman, Rolf Larsson, Urban Gullberg, Kenneth Nilsson, Fredrik Öberg, Helena Jernberg Wiklund

AB0 blood group and prognosis in patients with pancreatic cancer

Open Access
Research article

Nuh N Rahbari, Ulrich Bork, Ulf Hinz, Albrecht Leo, Johanna Kirchberg, Moritz Koch, Markus W Büchler, Jürgen Weitz

LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival

Open Access
Research article

Jan Dominik Kuhlmann, Heidi Schwarzenbach, Pauline Wimberger, Micaela Poetsch, Rainer Kimmig, Sabine Kasimir-Bauer

Different metastatic pattern according to the KRAS mutational status and site-specific discordance of KRAS status in patients with colorectal cancer

Open Access
Research article

Mi-Jung Kim, Hye Seung Lee, Jee Hyun Kim, Yu Jung Kim, Ji Hyun Kwon, Jeong-Ok Lee, Soo-Mee Bang, Kyoung Un Park, Duck-Woo Kim, Sung-Bum Kang, Jae-Sung Kim, Jong Seok Lee, Keun-Wook Lee

BAC CGH-array identified specific small-scale genomic imbalances in diploid DMBA-induced rat mammary tumors

Open Access
Research article

Emma Samuelson, Sara Karlsson, Karolina Partheen, Staffan Nilsson, Claude Szpirer, Afrouz Behboudi

Economic costs of chemotherapy-induced febrile neutropenia among patients with non-Hodgkin’s lymphoma in European and Australian clinical practice

Open Access
Research article

Derek Weycker, Aurelie Danel, Anne Marciniak, Kate Bendall, Michael Lipsitz, Ruth Pettengell

Diabetes, glucose control, glucose lowering medications, and cancer risk: A 10-year population-based historical cohort

Open Access
Study protocol

Rachel Dankner, Ran Balicer, Paolo Boffetta, Lital Keinan Boker, Sylvan Wallenstein, Laurence Freedman, Margalit Goldfracht, Jesse Roth, Ronald Tamler, Derek LeRoith

The contribution of the ABCG2 C421A polymorphism to cancer susceptibility: a meta-analysis of the current literature

Open Access
Research article

Pin Chen, Lin Zhao, Peng Zou, Haitao Xu, Ailin Lu, Peng Zhao

Natural resistance to cancers: a Darwinian hypothesis to explain Peto’s paradox

Open Access
Debate

Benjamin Roche, Michael E Hochberg, Aleah F Caulin, Carlo C Maley, Robert A Gatenby, Dorothée Misse, Frédéric Thomas

Quality of life across chemotherapy lines in patients with cancers of the pancreas and biliary tract

Open Access
Research article

August Zabernigg, Johannes M Giesinger, Georg Pall, Eva-Maria Gamper, Klaus Gattringer, Lisa M Wintner, Monika J Sztankay, Bernhard Holzner

Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesis

Open Access
Research article

Mina Waraya, Keishi Yamashita, Hiroshi Katoh, Akira Ooki, Hiroshi Kawamata, Hiroshi Nishimiya, Kazunori Nakamura, Akira Ema, Masahiko Watanabe

HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issues

Open Access
Correspondence

Margaret A Stanley, David M Winder, Jane C Sterling, Peter KC Goon

Analysis of and prognostic information from disseminated tumour cells in bone marrow in primary breast cancer: a prospective observational study

Open Access
Research article

Anna-Karin Falck, Pär-Ola Bendahl, Christian Ingvar, Jorma Isola, Per-Ebbe Jönsson, Pia Lindblom, Kristina Lövgren, Karin Rennstam, Mårten Fernö, Lisa Rydén

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I

Open Access
Research article

Afsar Ali Mian, Anna Metodieva, Susanne Badura, Mamduh Khateb, Nili Ruimi, Yousef Najajreh, Oliver Gerhard Ottmann, Jamal Mahajna, Martin Ruthardt

The changes of Th17 cells and the related cytokines in the progression of human colorectal cancers

Open Access
Research article

Jiansheng Wang, Kaiyu Xu, Jing Wu, Chenghua Luo, Yuchen Li, Xuebin Wu, Hong Gao, Guosheng Feng, Bao-Zhu Yuan

Hypoxic enhancement of exosome release by breast cancer cells

Open Access
Research article

Hamish W King, Michael Z Michael, Jonathan M Gleadle

Targeting of CD34+CD38-cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in acute Myeloid Leukaemia

Open Access
Research article

Mays Jawad, Ning Yu, Claire Seedhouse, Karuna Tandon, Nigel H Russell, Monica Pallis

Breast density as indicator for the use of mammography or MRI to screen women with familial risk for breast cancer (FaMRIsc): a multicentre randomized controlled trial

Open Access
Study protocol

Sepideh Saadatmand, Emiel J T Rutgers, RobAEM Tollenaar, Hermien M Zonderland, MargreetGEM Ausems, KristienBMI Keymeulen, Margreet S Schlooz-Vries, Linetta B Koppert, Eveline A M Heijnsdijk, Caroline Seynaeve, Cees Verhoef, Jan C Oosterwijk, Inge-Marie Obdeijn, Harry J de Koning, Madeleine M A Tilanus-Linthorst

Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: Increased expression of a CD44 variant isoform after chemotherapy

Open Access
Case report

Go J Yoshida, Yasushi Fuchimoto, Tomoo Osumi, Hiroyuki Shimada, Seiichi Hosaka, Hideo Morioka, Makio Mukai, Yohei Masugi, Michiie Sakamoto, Tatsuo Kuroda

Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis

Open Access
Research article

Jie Chen, Dehuan Shi, Xiaoyan Liu, Shuang Fang, Jie Zhang, Yueran Zhao

Phase I trial of split-dose induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1)

Open Access
Research article

Katrin Oertel, Karin Spiegel, Harald Schmalenberg, Andreas Dietz, Georg Maschmeyer, Thomas Kuhnt, Holger Sudhoff, Thomas G Wendt, Orlando Guntinas-Lichius

Sorafenib modulates the radio sensitivity of hepatocellular carcinoma cells in vitro in a schedule-dependent manner

Open Access
Research article

Qiaoqiao Li, Yonghong Hu, Mian Xi, Liru He, Lei Zhao, Mengzhong Liu

Measuring the quality of MDT working: an observational approach

Open Access
Research article

Cath Taylor, Louise Atkins, Alison Richardson, Ruth Tarrant, Amanda-Jane Ramirez

Effects on human transcriptome of mutated BRCA1 BRCT domain: A microarray study

Open Access
Research article

Caterina Iofrida, Erika Melissari, Veronica Mariotti, Chiara Guglielmi, Lucia Guidugli, Maria Adelaide Caligo, Silvia Pellegrini

Has the time to come leave the “watch-and-wait” strategy in newly diagnosed asymptomatic follicular lymphoma patients?

Open Access
Debate

Antonio Rueda, María Casanova, Maximino Redondo, Elisabeth Pérez-Ruiz, Ángeles Medina-Pérez

Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia

Open Access
Research article

Evgeny A Moskalev, Katrin Luckert, Ivan A Vorobjev, Sergey E Mastitsky, Aleena A Gladkikh, Achim Stephan, Marita Schrenk, Kamil D Kaplanov, Olga B Kalashnikova, Oliver Pötz, Thomas O Joos, Jörg D Hoheisel

Effectiveness of prophylactic retropharyngeal lymph node irradiation in patients with locally advanced head and neck cancer

Open Access
Research article

Nam P Nguyen, Jacqueline Vock, Vincent Vinh-Hung, Fabio Almeida, Lars Ewell, Michael Betz, Siyoung Jang, Richard A Vo, Suresh Dutta, Juan Godinez, Ulf Karlsson, Alexander Chi

The role of versican G3 domain in regulating breast cancer cell motility including effects on osteoblast cell growth and differentiation in vitro– evaluation towards understanding breast cancer cell bone metastasis

Open Access
Research article

William Weidong Du, Ling Fang, Weining Yang, Wang Sheng, Yaou Zhang, Arun Seth, Burton B Yang, Albert J Yee

Simultaneous copy number gains of NUPR1 and ERBB2 predicting poor prognosis in early-stage breast cancer

Open Access
Research article

Seung-Hyun Jung, Ahwon Lee, Seon-Hee Yim, Hae-Jin Hu, Chungyoul Choe, Yeun-Jun Chung

Sunitinib treatment does not improve blood supply but induces hypoxia in human melanoma xenografts

Open Access
Research article

Jon-Vidar Gaustad, Trude G Simonsen, Marit N Leinaas, Einar K Rofstad

Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa

Open Access
Research article

Adriana C Vidal, Pauline Kay Lund, Cathrine Hoyo, Joseph Galanko, Lauren Burcal, Rachel Holston, Berri Massa, Oluwaseun Omofoye, Robert S Sandler, Temitope O Keku

Design and rationale of FOCUS (PX-171-011): A randomized, open-label, phase 3 study of carfilzomib versus best supportive care regimen in patients with relapsed and refractory multiple myeloma (R/R MM)

Open Access
Study protocol

Roman Hájek, Richard Bryce, Sunhee Ro, Barbara Klencke, Heinz Ludwig

Intracranial melanocytic meningeal tumours and melanosis oculi: case report and literature review

Open Access
Case report

Francesco Doglietto, Cesare Colosimo, Libero Lauriola, Mario Balducci, Pasquale De Bonis, Nicola Montano, Gelareh Zadeh, Giulio Maira, Roberto Pallini

MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma

Open Access
Research article

Jian Wang, Jingwu Li, Junling Shen, Chen Wang, Lili Yang, Xinwei Zhang

Risk of tobacco-related multiple primary cancers in Bavaria, Germany

Open Access
Research article

Ulrike Braisch, Martin Meyer, Martin Radespiel-Tröger

Phosphorylation of transglutaminase 2 (TG2) at serine-216 has a role in TG2 mediated activation of nuclear factor-kappa B and in the downregulation of PTEN

Open Access
Research article

Yi Wang, Sudharsana R Ande, Suresh Mishra

Tumor response and survival in patients with advanced non-small-cell lung cancer: the predictive value of chemotherapy-induced changes in fibrinogen

Open Access
Research article

Jun Zhao, Mingfang Zhao, Bo Jin, Ping Yu, Xuejun Hu, Yuee Teng, Jingdong Zhang, Ying Luo, Lingyun Zhang, Shuang Zheng, Qiyin Zhou, Heming Li, Yunpeng Liu, Xiujuan Qu

Interstitial magnetic resonance lymphography is an effective diagnostic tool for the detection of lymph node metastases in patients with cervical cancer

Open Access
Research article

Ying Hong, Luojun Xiang, Yali Hu, Zhengyang Zhou, Haiping Yu, Bing Zhu

The T-box transcription factor Brachyury regulates epithelial–mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cells

Open Access
Research article

Miyuki Shimoda, Tsuyoshi Sugiura, Ikumi Imajyo, Kotaro Ishii, Satomi Chigita, Katsuhiro Seki, Yousuke Kobayashi, Kanemitsu Shirasuna

Engineered measles virus Edmonston strain used as a novel oncolytic viral system against human hepatoblastoma

Open Access
Research article

Shu-Cheng Zhang, Wei-Lin Wang, Wei-Song Cai, Kai-Lei Jiang, Zheng-Wei Yuan

Cost-effectiveness of a 21-gene recurrence score assay versus Canadian clinical practice in women with early-stage estrogen- or progesterone-receptor-positive, axillary lymph-node negative breast cancer

Open Access
Research article

Malek B Hannouf, Bin Xie, Muriel Brackstone, Gregory S Zaric

Maintenance bevacizumab beyond first-line paclitaxel plus bevacizumab in patients with Her2-negative hormone receptor-positive metastatic breast cancer: efficacy in combination with hormonal therapy

Open Access
Research article

Alessandra Fabi, Michelangelo Russillo, Gianluigi Ferretti, Giulio Metro, Cecilia Nisticò, Paola Papaldo, Ferdinando De Vita, Giuliana D’Auria, Antonello Vidiri, Diana Giannarelli, Francesco Cognetti

Lipocalin 2 expression is associated with aggressive features of endometrial cancer

Open Access
Research article

Monica Mannelqvist, Ingunn M Stefansson, Elisabeth Wik, Kanthida Kusonmano, Maria B Raeder, Anne M Øyan, Karl-Henning Kalland, Marsha A Moses, Helga B Salvesen, Lars A Akslen

Cost effectivenes of erlotinib versus chemotherapy for first-line treatment of non small cell lung cancer (NSCLC) in fit elderly patients participating in a prospective phase 2 study (GFPC 0504)

Open Access
Research article

Chouaid Christos, Le Caer Hervé, Locher Chrystelle, Dujon Cecile, Thomas Pascal, Auliac Jean Bernard, Monnet Isabelle, Vergnenegre Alain

Double-blind, placebo-controlled first in human study to investigate an oral vaccine aimed to elicit an immune reaction against the VEGF-Receptor 2 in patients with stage IV and locally advanced pancreatic cancer

Open Access
Study protocol

Andreas G Niethammer, Heinz Lubenau, Gerd Mikus, Philipp Knebel, Nicolas Hohmann, Christine Leowardi, Philipp Beckhove, Mustafa Akhisaroglu, Yingzi Ge, Marco Springer, Lars Grenacher, Markus W Buchler, Moritz Koch, Jürgen Weitz, Walter E Haefeli, Friedrich H Schmitz-Winnenthal

Elevated levels of serum amyloid A indicate poor prognosis in patients with esophageal squamous cell carcinoma

Open Access
Research article

Jun-Ye Wang, Yu-Zhen Zheng, Juan Yang, Yue-Hao Lin, Shu-Qin Dai, Ge Zhang, Wan-Li Liu

Knock-down of NDRG2 sensitizes cervical cancer Hela cells to cisplatin through suppressing Bcl-2 expression

Open Access
Research article

Junye Liu, Le Yang, Jian Zhang, Jing Zhang, Yongbin Chen, Kangchu Li, Yurong Li, Yan Li, Libo Yao, Guozhen Guo

Health-related quality of life in survivors of stage I-II breast cancer: randomized trial of post-operative conventional radiotherapy and hypofractionated tomotherapy

Open Access
Research article

Harijati Versmessen, Vincent Vinh-Hung, Hilde Van Parijs, Geertje Miedema, Mia Voordeckers, Nele Adriaenssens, Guy Storme, Mark De Ridder

Validation of podocalyxin-like protein as a biomarker of poor prognosis in colorectal cancer

Open Access
Research article

Anna Larsson, Marie Fridberg, Alexander Gaber, Björn Nodin, Per Levéen, Göran Jönsson, Mathias Uhlén, Helgi Birgisson, Karin Jirström

Dynamic tumor modeling of the dose–response relationship for everolimus in metastatic renal cell carcinoma using data from the phase 3 RECORD-1 trial

Open Access
Research article

Andrew Stein, Wenping Wang, Alison A Carter, Ovidiu Chiparus, Norbert Hollaender, Hyewon Kim, Robert J Motzer, Celine Sarr

Prognostic impact of detecting viable circulating tumour cells in gastric cancer patients using a telomerase-specific viral agent: a prospective study

Open Access
Research article

Hiroaki Ito, Haruhiro Inoue, Norimasa Sando, Satoshi Kimura, Keigo Gohda, Jun Sato, Katsuhiro Murakami, Shun Ito, Noriko Odaka, Hitoshi Satodate, Shin-ei Kudo

Reverse translation of phase I biomarker findings links the activity of angiotensin-(1–7) to repression of hypoxia inducible factor-1α in vascular sarcomas

Open Access
Research article

W Jeffrey Petty, Mebea Aklilu, Victor A Varela, James Lovato, Paul D Savage, Antonius A Miller

First case of isolated vaginal metastasis from breast cancer treated by surgery

Open Access
Case report

Filippo Bellati, Innocenza Palaia, Maria Luisa Gasparri, Angela Musella, Pierluigi Benedetti Panici

L-DOPA decarboxylase mRNA expression is associated with tumor stage and size in head and neck squamous cell carcinoma: a retrospective cohort study

Open Access
Research article

Panagiota-Aikaterini Geomela, Christos K Kontos, Ioannis Yiotakis, Emmanuel G Fragoulis, Andreas Scorilas

Hypofractionated helical intensity-modulated radiotherapy of the prostate bed after prostatectomy with or without the pelvic lymph nodes - the PRIAMOS trial

Open Access
Study protocol

Sonja Krause, Florian Sterzing, Dirk Neuhof, Lutz Edler, Juergen Debus, Klaus Herfarth

Cancer and non-cancer brain and eye effects of chronic low-dose ionizing radiation exposure

Open Access
Review

Eugenio Picano, Eliseo Vano, Luciano Domenici, Matteo Bottai, Isabelle Thierry-Chef

Does access to a colorectal cancer screening website and/or a nurse-managed telephone help line provided to patients by their family physician increase fecal occult blood test uptake?: A pragmatic cluster randomized controlled trial study protocol

Open Access
Study protocol

Kathleen Clouston, Alan Katz, Patricia J Martens, Jeff Sisler, Donna Turner, Michelle Lobchuk, Susan McClement

Necdin modulates proliferative cell survival of human cells in response to radiation-induced genotoxic stress

Open Access
Research article

Julie Lafontaine, Guergana Tchakarska, Francis Rodier, Anne-Marie Mes-Masson

Expanded clinical and experimental use of SOX11 - using a monoclonal antibody

Open Access
Technical advance

Lena Nordström, Ulrika Andréasson, Mats Jerkeman, Michael Dictor, Carl Borrebaeck, Sara Ek

Identification of BIRC6 as a novel intervention target for neuroblastoma therapy

Open Access
Research article

Fieke Lamers, Linda Schild, Jan Koster, Frank Speleman, Ingrid Øra, Ellen M Westerhout, Peter van Sluis, Rogier Versteeg, Huib N Caron, Jan J Molenaar

A Clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcoma

Open Access
Study protocol

Falk Roeder, Daniela Schulz-Ertner, Anna V Nikoghosyan, Peter E Huber, Lutz Edler, Gregor Habl, Robert Krempien, Susanne Oertel, Ladan Saleh-Ebrahimi, Frank W Hensley, Markus W Buechler, Juergen Debus, Moritz Koch, Juergen Weitz, Marc Bischof

Vaccinia virus-mediated intra-tumoral expression of matrix metalloproteinase 9 enhances oncolysis of PC-3 xenograft tumors

Open Access
Research article

Simon Schäfer, Stephanie Weibel, Ulrike Donat, Qian Zhang, Richard J Aguilar, Nanhai G Chen, Aladar A Szalay

Deregulation of miR-100, miR-99a and miR-199b in tissues and plasma coexists with increased expression of mTOR kinase in endometrioid endometrial carcinoma

Open Access
Research article

Anna Torres, Kamil Torres, Anna Pesci, Marcello Ceccaroni, Tomasz Paszkowski, Paola Cassandrini, Giuseppe Zamboni, Ryszard Maciejewski

High incidence of microsatellite instability and loss of heterozygosity in three loci in breast cancer patients receiving chemotherapy: a prospective study

Open Access
Research article

Nasir Kamat, Mohammed A Khidhir, Mohammed Jaloudi, Sabir Hussain, Mouied M Alashari, Khaled H Al Qawasmeh, Ulf Rannug

Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization

Open Access
Research article

Allan D Heibein, Baoqing Guo, Jason A Sprowl, David A MacLean, Amadeo M Parissenti

Loss-of-heterozygosity on chromosome 19q in early-stage serous ovarian cancer is associated with recurrent disease

Open Access
Research article

Ingiridur Skirnisdottir, Markus Mayrhofer, Maria Rydåker, Helena Åkerud, Anders Isaksson

Pleural fluid cell-free DNA integrity index to identify cytologically negative malignant pleural effusions including mesotheliomas

Open Access
Research article

Krishna B Sriram, Vandana Relan, Belinda E Clarke, Edwina E Duhig, Morgan N Windsor, Kevin S Matar, Rishendran Naidoo, Linda Passmore, Elizabeth McCaul, Deborah Courtney, Ian A Yang, Rayleen V Bowman, Kwun M Fong

A closed-tube methylation-sensitive high resolution melting assay (MS-HRMA) for the semi-quantitative determination of CST6 promoter methylation in clinical samples

Open Access
Research article

Lampros Dimitrakopoulos, Panagiotis A Vorkas, Vasilis Georgoulias, Evi S Lianidou

BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors

Open Access
Research article

Stephane Boeuf, Judith VMG Bovée, Burkhard Lehner, Brendy van den Akker, Maayke van Ruler, Anne-Marie Cleton-Jansen, Wiltrud Richter

LFA-1 and ICAM-1 expression induced during melanoma-endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro

Open Access
Research article

Stephanie Ghislin, Dorian Obino, Sandrine Middendorp, Nicole Boggetto, Catherine Alcaide-Loridan, Frederique Deshayes

PR-104 a bioreductive pre-prodrug combined with gemcitabine or docetaxel in a phase Ib study of patients with advanced solid tumours

Open Access
Research article

Mark J McKeage, Michael B Jameson, Ramesh K Ramanathan, Joseph Rajendran, Yongchuan Gu, William R Wilson, Teresa J Melink, N Simon Tchekmedyian

Different fatty acid metabolism effects of (−)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer

Open Access
Research article

Joana Relat, Adriana Blancafort, Glòria Oliveras, Sílvia Cufí, Diego Haro, Pedro F Marrero, Teresa Puig

Impact of treatment with bevacizumab beyond disease progression: a randomized phase II study of docetaxel with or without bevacizumab after platinum-based chemotherapy plus bevacizumab in patients with advanced nonsquamous non–small cell lung cancer (WJOG 5910L)

Open Access
Study protocol

Masayuki Takeda, Isamu Okamoto, Takeharu Yamanaka, Kazuhiko Nakagawa, Yoichi Nakanishi

DEXA measures of body fat percentage and acute phase proteins among breast cancer survivors: a Cross-Sectional Analysis

Open Access
Research article

Anne Dee, Roberta McKean-Cowdin, Marian L Neuhouser, Cornelia Ulrich, Richard N Baumgartner, Anne McTiernan, Kathy Baumgartner, Catherine M Alfano, Rachel Ballard-Barbash, Leslie Bernstein

Human pancreatic adenocarcinoma contains a side population resistant to gemcitabine

Open Access
Research article

Anke Van den broeck, Lies Gremeaux, Baki Topal, Hugo Vankelecom

Expression of ERBB3 binding protein 1 (EBP1) in salivary adenoid cystic carcinoma and its clinicopathological relevance

Open Access
Research article

Jian Sun, Yixi Luo, Zhen Tian, Liang Gu, Shu Chi Xia, Youcheng Yu

Increased financial burden among patients with chronic myelogenous leukaemia receiving imatinib in Japan: a retrospective survey

Open Access
Research article

Yuko Kodama, Ryoko Morozumi, Tomoko Matsumura, Yukiko Kishi, Naoko Murashige, Yuji Tanaka, Morihito Takita, Nobuyo Hatanaka, Eiji Kusumi, Masahiro Kami, Akihiko Matsui

Stepped care targeting psychological distress in head and neck and lung cancer patients: a randomized clinical trial

Open Access
Study protocol

Anne-Marie H Krebber, C René Leemans, Remco de Bree, Annemieke van Straten, Filip Smit, Egbert F Smit, Annemarie Becker, Guus M Eeckhout, Aartjan TF Beekman, Pim Cuijpers, Irma M Verdonck-de Leeuw

Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition

Open Access
Research article

Tobias M Gorges, Ingeborg Tinhofer, Michael Drosch, Lars Röse, Thomas M Zollner, Thomas Krahn, Oliver von Ahsen

Li-Fraumeni-like syndrome associated with a large BRCA1 intragenic deletion

Open Access
Research article

Amanda Gonçalves Silva, Ingrid Petroni Ewald, Marina Sapienza, Manuela Pinheiro, Ana Peixoto, Amanda França de Nóbrega, Dirce M Carraro, Manuel R Teixeira, Patricia Ashton-Prolla, Maria Isabel W Achatz, Carla Rosenberg, Ana C V Krepischi

Options for early breast cancer follow-up in primary and secondary care - a systematic review

Open Access
Research article

Frances Taggart, Peter Donnelly, Janet Dunn

Predictors of competing mortality to invasive breast cancer incidence in the Canadian National Breast Screening study

Open Access
Research article

Sharareh Taghipour, Dragan Banjevic, Joanne Fernandes, Anthony B Miller, Neil Montgomery, Andrew K S Jardine, Bart J Harvey

Do children with central venous line (CVL) dysfunction have increased risk of symptomatic thromboembolism compared to those without CVL-dysfunction, while on cancer therapy?

Open Access
Study protocol

Jacqueline Halton, Kim Nagel, Leonardo R Brandão, Mariana Silva, Paul Gibson, Anthony Chan, Kay Blyth, Kim Hicks, Nagina Parmar, Leslie Paddock, Stephanie Willing, Lehana Thabane, Uma Athale

A case–control study of occupation/industry and renal cell carcinoma risk

Open Access
Research article

Sara Karami, Joanne S Colt, Kendra Schwartz, Faith G Davis, Julie J Ruterbusch, Stella S Munuo, Sholom Wacholder, Patricia A Stewart, Barry I Graubard, Nathanial Rothman, Wong-Ho Chow, Mark P Purdue

Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells

Open Access
Research article

Massimiliano Monticone, Antonio Daga, Simona Candiani, Francesco Romeo, Valentina Mirisola, Silvia Viaggi, Ilaria Melloni, Simona Pedemonte, Gianluigi Zona, Walter Giaretti, Ulrich Pfeffer, Patrizio Castagnola

Effects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis

Open Access
Research article

Herta H Chao, Edward Uchio, Sheng Zhang, Sien Hu, Sarah R Bednarski, Xi Luo, Michal Rose, John Concato, Chiang-shan R Li

Thrombospondin-1-derived 4N1K peptide expression is negatively associated with malignant aggressiveness and prognosis in urothelial carcinoma of the upper urinary tract

Open Access
Research article

Yasuyoshi Miyata, Shin-ichi Watanabe, Hiroshi Kanetake, Hideki Sakai

A novel multiplex-protein array for serum diagnostics of colon cancer: a case–control study

Open Access
Research article

Stefanie Bünger, Ulrike Haug, Maria Kelly, Nicole Posorski, Katja Klempt-Giessing, Andrew Cartwright, Stephen P Fitzgerald, Vicki Toner, Damien McAleer, Timo Gemoll, Tilman Laubert, Jürgen Büning, Klaus Fellermann, Hans-Peter Bruch, Uwe J Roblick, Hermann Brenner, Ferdinand von Eggeling, Jens K Habermann

Validation of CRP as prognostic marker for renal cell carcinoma in a large series of patients

Open Access
Research article

Sandra Steffens, Astrid Köhler, Raphael Rudolph, Hendrik Eggers, Christoph Seidel, Martin Janssen, Gerd Wegener, Mark Schrader, Markus A Kuczyk, Andres J Schrader

Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway

Open Access
Research article

Lili Jiang, Jueheng Wu, Yi Yang, Liping Liu, Libing Song, Jun Li, Mengfeng Li

A comparison of survival outcomes and side effects of toremifene or tamoxifen therapy in premenopausal estrogen and progesterone receptor positive breast cancer patients: a retrospective cohort study

Open Access
Research article

Ran Gu, Weijuan Jia, Yunjie Zeng, Nanyan Rao, Yue Hu, Shunrong Li, Jiannan Wu, Liang Jin, Lijuan Chen, Meijun Long, Kai Chen, Lili Chen, Qiaozhen Xiao, Mei Wu, Erwei Song, Fengxi Su

Insulin-like growth factors in endometrioid adenocarcinoma: Correlation with clinico-pathological features and estrogen receptor expression

Open Access
Research article

Yuan-Jiao Liang, Qun Hao, Hui-Ming Zhang, Yuan-Zhe Wu, Jian-Dong Wang

Online group-based cognitive-behavioural therapy for adolescents and young adults after cancer treatment: A multicenter randomised controlled trial of Recapture Life-AYA

Open Access
Study protocol

Ursula M Sansom-Daly, Claire E Wakefield, Richard A Bryant, Phyllis Butow, Susan Sawyer, Pandora Patterson, Antoinette Anazodo, Kate Thompson, Richard J Cohn

Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)

Open Access
Research article

Vassiliki Kotoula, Dimitrios Krikelis, Vasilios Karavasilis, Triantafillia Koletsa, Anastasia G Eleftheraki, Despina Televantou, Christos Christodoulou, Stefanos Dimoudis, Ippokratis Korantzis, Dimitrios Pectasides, Konstantinos N Syrigos, Paris A Kosmidis, George Fountzilas

MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5

Open Access
Research article

Xiang-hua Liu, Kai-hua Lu, Ke-ming Wang, Ming Sun, Er-bao Zhang, Jin-song Yang, Dan-dan Yin, Zhi-li Liu, Jing Zhou, Zhi-jun Liu, Wei De, Zhao-xia Wang

Treatment with bevacizumab and FOLFOXIRI in patients with advanced colorectal cancer: presentation of two novel trials (CHARTA and PERIMAX) and review of the literature

Open Access
Study protocol

Alexander Stein, Gabriel Glockzin, Andreas Wienke, Dirk Arnold, Thomas Edelmann, Bert Hildebrandt, Stephan Hollerbach, Gerald Illerhaus, Alfred Königsrainer, Michael Richter, Hans J Schlitt, Hans-Joachim Schmoll

Correlation between Duffy blood group phenotype and breast cancer incidence

Open Access
Research article

Xiao-feng Liu, Lian-fang Li, Zhou-luo Ou, Rong Shen, Zhi-min Shao

A molecular computational model improves the preoperative diagnosis of thyroid nodules

Open Access
Research article

Sara Tomei, Ivo Marchetti, Katia Zavaglia, Francesca Lessi, Alessandro Apollo, Paolo Aretini, Giancarlo Di Coscio, Generoso Bevilacqua, Chiara Mazzanti

EXERCISE in pediatric autologous stem cell transplant patients: a randomized controlled trial protocol

Open Access
Study protocol

Carolina Chamorro-Viña, Gregory MT Guilcher, Faisal M Khan, Karen Mazil, Fiona Schulte, Amanda Wurz, Tanya Williamson, Raylene A Reimer, S Nicole Culos-Reed

SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors

Open Access
Research article

Antoine Italiano, Chun-Liang Chen, Yun-Shao Sung, Samuel Singer, Ronald P DeMatteo, Michael P LaQuaglia, Peter Besmer, Nicholas Socci, Cristina R Antonescu

WRAP53 is an independent prognostic factor in rectal cancer- a study of Swedish clinical trial of preoperative radiotherapy in rectal cancer patients

Open Access
Research article

Hong Zhang, Da-Wei Wang, Gunnar Adell, Xiao-Feng Sun

Generation of a selectively cytotoxic fusion protein against p53 mutated cancers

Open Access
Research article

Christina A Kousparou, Efthymia Yiacoumi, Mahendra P Deonarain, Agamemnon A Epenetos

Systematic review with meta-analysis of the epidemiological evidence in the 1900s relating smoking to lung cancer

Open Access
Research article

Peter N Lee, Barbara A Forey, Katharine J Coombs

A comparative population-based study of prostate cancer incidence and mortality rates in Singapore, Sweden and Geneva, Switzerland from 1973 to 2006

Open Access
Research article

Cynthia Chen, Nasheen Naidoo, Qian Yang, Mikael Hartman, Helena M Verkooijen, En Yun Loy, Christine Bouchardy, Kee Seng Chia, Sin Eng Chia

Rationale and design of a multicenter prospective cohort study for the eVALuation and monitoring of HPV infections and relATEd cervical diseases in high-risk women (VALHIDATE study)

Open Access
Study protocol

Giovanna Orlando, Elisabetta Tanzi, Liliane Chatenoud, Maria Gramegna, Giuliano Rizzardini

Beyond KRAS mutation status: influence of KRAScopy number status and microRNAs on clinical outcome to cetuximab in metastatic colorectal cancer patients

Open Access
Research article

Leonie JM Mekenkamp, Jolien Tol, Jeroen R Dijkstra, Inge de Krijger, M Elisa Vink-Börger, Shannon van Vliet, Steven Teerenstra, Eveline Kamping, Eugène Verwiel, Miriam Koopman, Gerrit A Meijer, J Han JM van Krieken, Roland Kuiper, Cornelis JA Punt, Iris D Nagtegaal

A randomised trial of robotic and open prostatectomy in men with localised prostate cancer

Open Access
Study protocol

Robert A Gardiner, John Yaxley, Geoff Coughlin, Nigel Dunglison, Stefano Occhipinti, Sandra Younie, Rob Carter, Scott Williams, Robyn J Medcraft, Nigel Bennett, Martin F Lavin, Suzanne Kathleen Chambers

Eicosapentaenoic acid (EPA) efficacy for colorectal aberrant crypt foci (ACF): a double-blind randomized controlled trial

Open Access
Study protocol

Takuma Higurashi, Kunihiro Hosono, Hiroki Endo, Hirokazu Takahashi, Hiroshi Iida, Takashi Uchiyama, Akiko Ezuka, Shiori Uchiyama, Eiji Yamada, Hidenori Ohkubo, Eiji Sakai, Shin Maeda, Satoshi Morita, Yutaka Natsumeda, Hajime Nagase, Atsushi Nakajima

A case of lung adenocarcinoma harboring EGFR mutation and EML4-ALKfusion gene

Open Access
Case report

Hisashi Tanaka, Akihito Hayashi, Takeshi Morimoto, Kageaki Taima, Yoshihito Tanaka, Michiko Shimada, Akira Kurose, Shingo Takanashi, Ken Okumura

A systematic review of the impact of stigma and nihilism on lung cancer outcomes

Open Access
Research article

Suzanne K Chambers, Jeffrey Dunn, Stefano Occhipinti, Suzanne Hughes, Peter Baade, Sue Sinclair, Joanne Aitken, Pip Youl, Dianne L O’Connell

Methylseleninic acid restricts tumor growth in nude mice model of metastatic breast cancer probably via inhibiting angiopoietin-2

Open Access
Research article

Xiaojing Wu, Yidi Zhang, Zengyang Pei, Si Chen, Xu Yang, Yin Chen, Degui Lin, Runlin Z Ma

Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo

Open Access
Research article

Yantao Du, Zhaojun Liu, Liankun Gu, Jing Zhou, Bu-dong Zhu, Jiafu Ji, Dajun Deng

Efficacy of walking exercise in promoting cognitive-psychosocial functions in men with prostate cancer receiving androgen deprivation therapy

Open Access
Study protocol

C Ellen Lee, Andrea Kilgour, YK James Lau

miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma

Open Access
Research article

Jelena Põlajeva, Fredrik J Swartling, Yiwen Jiang, Umashankar Singh, Kristian Pietras, Lene Uhrbom, Bengt Westermark, Pernilla Roswall

Time to follow up after an abnormal finding in organized gastric cancer screening in Korea

Open Access
Research article

Hoo-Yeon Lee, Kui Son Choi, Jae Kwan Jun, Myung-Il Hahm, Eun-Cheol Park

Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines

Open Access
Research article

Fatima Rangwala, Kevin P Williams, Ginger R Smith, Zainab Thomas, Jennifer L Allensworth, H Kim Lyerly, Anna Mae Diehl, Michael A Morse, Gayathri R Devi

The effect of metformin and thiazolidinedione use on lung cancer in diabetics

Open Access
Research article

Peter J Mazzone, Hardeep Rai, Mary Beukemann, Meng Xu, Anil Jain, Madhu Sasidhar

Postmenopausal breast cancer in Iran; risk factors and their population attributable fractions

Open Access
Research article

Reza Ghiasvand, Shahram Bahmanyar, Kazem Zendehdel, Sedigheh Tahmasebi, Abdolrasoul Talei, Hans-Olov Adami, Sven Cnattingius

Blastomatoid pulmonary carcinosarcoma: report of a case with a review of the literature

Open Access
Case report

Inga-Marie Schaefer, Carsten-Oliver Sahlmann, Tobias Overbeck, Stefan Schweyer, Jan Menke

A new score predicting the survival of patients with spinal cord compression from myeloma

Open Access
Research article

Sarah Douglas, Steven E Schild, Dirk Rades

Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs

Open Access
Research article

Laia Trigueros-Motos, Sandra Pérez-Torras, F Javier Casado, Míriam Molina-Arcas, Marçal Pastor-Anglada

Up-regulation of platelet-derived growth factor-A is responsible for the failure of re-initiated interferon alpha treatment in hepatocellular carcinoma

Open Access
Research article

Ju-Bo Zhang, Hui-Chuan Sun, Wei-Dong Jia, Peng-Yuan Zhuang, Yong-Bing Qian, Xiao-Dong Zhu, Ling-Qun Kong, Lu Wang, Wei-Zhong Wu, Zhao-You Tang

Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassay

Open Access
Research article

Kazuto Yoshimi, Takao Hashimoto, Yusuke Niwa, Kazuya Hata, Tadao Serikawa, Takuji Tanaka, Takashi Kuramoto

A Phase II study of pulse dose imatinib mesylate and weekly paclitaxel in patients aged 70 and over with advanced non-small cell lung cancer

Open Access
Research article

Julie E Bauman, Keith D Eaton, Sarah G Wallace, Laurie L Carr, Sang-Joon Lee, Dennie V Jones, Hugo Arias-Pulido, Lisa A Cerilli, Renato G Martins

Novel anti-HER2 monoclonal antibodies: synergy and antagonism with tumor necrosis factor-α

Open Access
Research article

Ceyhan Ceran, Murat Cokol, Sultan Cingoz, Ipek Tasan, Mehmet Ozturk, Tamer Yagci

Monocytes and the 38kDa-antigen of mycobacterium tuberculosis modulate natural killer cell activity and their cytolysis directed against ovarian cancer cell lines

Open Access
Research article

Nina Gottschalk, Stephan Lang, Rainer Kimmig, Mahavir Singh, Sven Brandau

Involvement of Akt/NF-κB pathway in antitumor effects of parthenolide on glioblastoma cells in vitro and in vivo

Open Access
Research article

Hiromichi Nakabayashi, Keiji Shimizu

Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan

Open Access
Research article

Stephen Hiscox, Bedanta Baruah, Chris Smith, Rebecca Bellerby, Lindy Goddard, Nicola Jordan, Zaruhi Poghosyan, Robert I Nicholson, Peter Barrett-Lee, Julia Gee

Loss of aquaporin 3 protein expression constitutes an independent prognostic factor for progression-free survival: an immunohistochemical study on stage pT1 urothelial bladder cancer

Open Access
Research article

Wolfgang Otto, Peter C Rubenwolf, Maximilian Burger, Hans-Martin Fritsche, Wolfgang Rößler, Matthias May, Arndt Hartmann, Ferdinand Hofstädter, Wolf F Wieland, Stefan Denzinger

Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck

Open Access
Research article

Hanneke Stegeman, Johannes H Kaanders, Deric L Wheeler, Albert J van der Kogel, Marieke M Verheijen, Stijn J Waaijer, Mari Iida, Reidar Grénman, Paul N Span, Johan Bussink

Population-based study of breast cancer in older women: prognostic factors of relative survival and predictors of treatment

Open Access
Research article

Pegdwende Olivia Dialla, Tienhan Sandrine Dabakuyo, Sophie Marilier, Julie Gentil, Patrick Roignot, Ariane Darut-Jouve, Marie-Laure Poillot, Valérie Quipourt, Patrick Arveux

Anal cytological abnormalities and epidemiological correlates among men who have sex with men at risk for HIV-1 infection

Open Access
Research article

Maria Gabriella Donà, Maria Benevolo, Amina Vocaturo, Guido Palamara, Alessandra Latini, Amalia Giglio, Domenico Moretto, Francesca Rollo, Giampaolo Impara, Fabrizio Ensoli, Fulvia Pimpinelli, Aldo Di Carlo, Massimo Giuliani

Genetic polymorphisms in the osteopontin promoter increases the risk of distance metastasis and death in Chinese patients with gastric cancer

Open Access
Research article

Fujun Zhao, Xiaoyi Chen, Tingting Meng, Bo Hao, Zhihong Zhang, Guoxin Zhang

Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma

Open Access
Research article

Durmus Burgucu, Kenan Guney, Duygu Sahinturk, Irem Hicran Ozbudak, Deniz Ozel, Gulay Ozbilim, Ugur Yavuzer

Treatment of medulloblastoma using an oncolytic measles virus encoding the thyroidal sodium iodide symporter shows enhanced efficacy with radioiodine

Open Access
Research article

Brian Hutzen, Christopher R Pierson, Stephen J Russell, Evanthia Galanis, Corey Raffel, Adam W Studebaker

Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cells

Open Access
Research article

Neka A K Simms, Ashwani Rajput, Elizabeth A Sharratt, Melanie Ongchin, Carol A Teggart, Jing Wang, Michael G Brattain

Protein markers of cancer-associated fibroblasts and tumor-initiating cells reveal subpopulations in freshly isolated ovarian cancer ascites

Open Access
Research article

My Wintzell, Elisabet Hjerpe, Elisabeth Åvall Lundqvist, Maria Shoshan

Low BRMS1 expression promotes nasopharyngeal carcinoma metastasis in vitro and in vivo and is associated with poor patient survival

Open Access
Research article

Rui-Xue Cui, Na Liu, Qing-Mei He, Wen-Fei Li, Bi-Jun Huang, Ying Sun, Ling-Long Tang, Mo Chen, Ning Jiang, Lei Chen, Jing-Ping Yun, Jing Zeng, Ying Guo, Hui-Yun Wang, Jun Ma

Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients

Open Access
Research article

Siv K Bøhn, Kjell M Russnes, Amrit K Sakhi, Magne Thoresen, Marit Holden, JanØ Moskaug, Mari C Myhrstad, Ole K Olstad, Sigbjørn Smeland, Rune Blomhoff

Wnt5a promotes ewing sarcoma cell migration through upregulating CXCR4 expression

Open Access
Research article

Zhe Jin, Chenghai Zhao, Xiaorui Han, Yaxin Han

Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses

Open Access
Research article

D Alan Anthoney, Jay Naik, Iain RJ MacPherson, Donna Crawford, John M Hartley, Janet A Hartley, Tomohisa Saito, Masaichi Abe, Keith Jones, Masanori Miwa, Christopher Twelves, TRJ Evans

Competitive amplification of differentially melting amplicons (CADMA) improves KRAS hotspot mutation testing in colorectal cancer

Open Access
Research article

Lasse Sommer Kristensen, Tina Ellegaard Kjeldsen, Henrik Hager, Lise Lotte Hansen

Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape

Open Access
Technical advance

Suzanne Snellenberg, Lise MA De Strooper, Albertus T Hesselink, Chris JLM Meijer, Peter JF Snijders, Daniëlle AM Heideman, Renske DM Steenbergen

A retrospective study investigating the rate of HER2 discordance between primary breast carcinoma and locoregional or metastatic disease

Open Access
Research article

Arlene Chan, Adrienne Morey, Belinda Brown, Diana Hastrich, Peter Willsher, David Ingram

Mode of primary cancer detection as an indicator of screening practice for second primary cancer in cancer survivors: a nationwide survey in Korea

Open Access
Research article

Beomseok Suh, Dong Wook Shin, So Young Kim, Jae-Hyun Park, Weon Young Chang, Seung Pyung Lim, Chang-Yeol Yim, Be-Long Cho, Eun-Cheol Park, Jong-Hyock Park

Complement activation in astrocytomas: deposition of C4d and patient outcome

Open Access
Research article

Katri Mäkelä, Pauli Helén, Hannu Haapasalo, Timo Paavonen

Expression profile and prognostic role of sex hormone receptors in gastric cancer

Open Access
Research article

Lu Gan, Jian He, Xia Zhang, Yong-Jie Zhang, Guan-Zhen Yu, Ying Chen, Jun Pan, Jie-Jun Wang, Xi Wang

Move more for life: the protocol for a randomised efficacy trial of a tailored-print physical activity intervention for post-treatment breast cancer survivors

Open Access
Study protocol

Camille E Short, Erica L James, Afaf Girgis, Patrick Mcelduff, Ronald C Plotnikoff

Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications

Open Access
Research article

Cuilan Li, Vincent WS Liu, Pui M Chiu, David W Chan, Hextan YS Ngan

Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma

Open Access
Research article

Toshihito Suda, Takanori Hama, Shu Kondo, Yuki Yuza, Mamoru Yoshikawa, Mitsuyoshi Urashima, Takakuni Kato, Hiroshi Moriyama

A systematic review of symptom assessment scales in children with cancer

Open Access
Research article

L Lee Dupuis, Marie-Chantal Ethier, Deborah Tomlinson, Tanya Hesser, Lillian Sung

Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1metabolic genes and risk of lung cancer in Asturias

Open Access
Research article

M Felicitas López-Cima, Sara M Álvarez-Avellón, Teresa Pascual, Ana Fernández-Somoano, Adonina Tardón

Downregulation of Cyclophilin A by siRNA diminishes non-small cell lung cancer cell growth and metastasis via the regulation of matrix metallopeptidase 9

Open Access
Research article

Zhe Qian, Xiaoting Zhao, Mei Jiang, Wenyun Jia, Chunyan Zhang, Yue Wang, Baolan Li, Wentao Yue

Time trends of cancer mortality among elderly in Italy, 1970–2008: an observational study

Open Access
Research article

Ettore Bidoli, Lucia Fratino, Silvia Bruzzone, Marilena Pappagallo, Paolo De Paoli, Umberto Tirelli, Diego Serraino

Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers

Open Access
Research article

Merete Bjørnslett, Stian Knappskog, Per Eystein Lønning, Anne Dørum

Deletion of the TNFAIP3/A20gene detected by FICTION analysis in classical Hodgkin lymphoma

Open Access
Research article

Junko Nomoto, Nobuhiro Hiramoto, Motohiro Kato, Masashi Sanada, Akiko Miyagi Maeshima, Hirokazu Taniguchi, Fumie Hosoda, Yoshitaka Asakura, Wataru Munakata, Naohiro Sekiguchi, Dai Maruyama, Takashi Watanabe, Hitoshi Nakagama, Kengo Takeuchi, Kensei Tobinai, Seishi Ogawa, Yukio Kobayashi

Conditional survival of cancer patients: an Australian perspective

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Research article

Xue Qin Yu, Peter D Baade, Dianne L O’Connell

Human α-defensin (DEFA) gene expression helps to characterise benign and malignant salivary gland tumours

Open Access
Research article

Jochen Winter, Annette Pantelis, Dominik Kraus, Jan Reckenbeil, Rudolf Reich, Soeren Jepsen, Hans-Peter Fischer, Jean-Pierre Allam, Natalija Novak, Matthias Wenghoefer

Adherence evaluation of endocrine treatment in breast cancer: methodological aspects

Open Access
Research article

Anne S Oberguggenberger, Monika Sztankay, Beate Beer, Birthe Schubert, Verena Meraner, Herbert Oberacher, Georg Kemmler, Johannes Giesinger, Eva Gamper, Barbara Sperner-Unterweger, Christian Marth, Bernhard Holzner, Michael Hubalek

Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma

Open Access
Research article

Egil S Blix, Jonathan M Irish, Anne Husebekk, Jan Delabie, Lise Forfang, Anne M Tierens, June H Myklebust, Arne Kolstad

miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells

Open Access
Research article

Ai-Yu Gong, Alex N Eischeid, Jing Xiao, Jian Zhao, Dongqing Chen, Zhao-Yi Wang, Charles YF Young, Xian-Ming Chen

Phenotype-dependent effects of EpCAM expression on growth and invasion of human breast cancer cell lines

Open Access
Research article

Agnieszka Martowicz, Gilbert Spizzo, Guenther Gastl, Gerold Untergasser

Junction region of EWS-FLI1 fusion protein has a dominant negative effect in Ewing’s Sarcoma in vitro

Open Access
Research article

Babu Jully, Ramshankar Vijayalakshmi, Gopisetty Gopal, Kesavan Sabitha, Thangarajan Rajkumar

In vitro and in vivoanti-tumor effect of metformin as a novel therapeutic agent in human oral squamous cell carcinoma

Open Access
Research article

Qingqiong Luo, Dan Hu, Shuiqing Hu, Ming Yan, Zujun Sun, Fuxiang Chen

Immunohistochemical analysis based Ep-ICD subcellular localization index (ESLI) is a novel marker for metastatic papillary thyroid microcarcinoma

Open Access
Research article

Tada Kunavisarut, Ipshita Kak, Christina MacMillan, Ranju Ralhan, Paul G Walfish

Genotype distribution of human papillomavirus (HPV) in histological sections of cervical intraepithelial neoplasia and invasive cervical carcinoma in Madrid, Spain

Open Access
Research article

Benjamín García-Espinosa, Ernesto Moro-Rodríguez, Emilio Álvarez-Fernández

Aberrant expression of CD133 in non-small cell lung cancer and its relationship to vasculogenic mimicry

Open Access
Research article

Shiwu Wu, Lan Yu, Danna Wang, Lei Zhou, Zenong Cheng, Damin Chai, Li Ma, Yisheng Tao

Long-term bresults of radiotherapy combined with nedaplatin and 5-fluorouracil for postoperative loco-regional recurrent esophageal cancer: update on a phase II study

Open Access
Research article

Keiichi Jingu, Haruo Matsushita, Ken Takeda, Rei Umezawa, Chiaki Takahashi, Toshiyuki Sugawara, Masaki Kubozono, Keiko Abe, Takaya Tanabe, Yuko Shirata, Takaya Yamamoto, Youjirou Ishikawa, Kenji Nemoto

Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231

Open Access
Research article

Arturo Aguilar-Rojas, Maira Huerta-Reyes, Guadalupe Maya-Núñez, Fabián Arechavaleta-Velásco, P Michael Conn, Alfredo Ulloa-Aguirre, Jesús Valdés

Patterns and timing of sunlight exposure and risk of basal cell and squamous cell carcinomas of the skin – a case–control study

Open Access
Research article

Michelle R Iannacone, Wei Wang, Heather G Stockwell, Kathleen O’Rourke, Anna R Giuliano, Vernon K Sondak, Jane L Messina, Richard G Roetzheim, Basil S Cherpelis, Neil A Fenske, Dana E Rollison

The oncoprotein and stem cell renewal factor BMI1 associates with poor clinical outcome in oesophageal cancer patients undergoing preoperative chemoradiotherapy

Open Access
Research article

Reigetsu Yoshikawa, Tohru Tsujimura, Lihua Tao, Norihiko Kamikonya, Yoshinori Fujiwara

Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer

Open Access
Research article

Kristina Schee, Kjetil Boye, Torveig Weum Abrahamsen, Øystein Fodstad, Kjersti Flatmark

A rare case of primary clear cell sarcoma of the pubic bone resembling small round cell tumor: an unusual morphological variant

Open Access
Case report

Shoko Nakayama, Taiji Yokote, Kazuki Iwaki, Toshikazu Akioka, Takuji Miyoshi, Yuji Hirata, Ayami Takayama, Uta Nishiwaki, Yuki Masuda, Motomu Tsuji, Toshiaki Hanafusa

Detection of Lipid-Rich Prostate Circulating Tumour Cells with Coherent Anti-Stokes Raman Scattering Microscopy

Open Access
Research article

Ranjana Mitra, Olivia Chao, Yasuyo Urasaki, Oscar B Goodman, Thuc T Le

TARGIT-E(lderly)—Prospective phase II study of intraoperative radiotherapy (IORT) in elderly patients with small breast cancer

Open Access
Study protocol

Christian Neumaier, Sperk Elena, Welzel Grit, Abo-Madyan Yasser, Kraus-Tiefenbacher Uta, Keller Anke, Gerhardt Axel, Sütterlin Marc, Wenz Frederik

TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells

Open Access
Research article

Lionel Flamant, Edith Roegiers, Michael Pierre, Aurélie Hayez, Christiane Sterpin, Olivier De Backer, Thierry Arnould, Yves Poumay, Carine Michiels

Can exercise ameliorate treatment toxicity during the initial phase of testosterone deprivation in prostate cancer patients? Is this more effective than delayed rehabilitation?

Open Access
Study protocol

Robert U Newton, Dennis R Taaffe, Nigel Spry, Prue Cormie, Suzanne K Chambers, Robert A Gardiner, David HK Shum, David Joseph, Daniel A Galvão

Skin toxicity and quality of life in patients with metastatic colorectal cancer during first-line panitumumab plus FOLFIRI treatment in a single-arm phase II study

Open Access
Research article

Josef Thaler, Meinolf Karthaus, Laurent Mineur, Richard Greil, Henry Letocha, Ralf Hofheinz, Eva Fernebro, Erick Gamelin, Ana Baños, Claus-Henning Köhne

Multiplicative synergistic risk of hepatocellular carcinoma development among hepatitis B and C co-infected subjects in HBV endemic area: a community-based cohort study

Open Access
Research article

Jin-Kyoung Oh, Hai-Rim Shin, Min Kyung Lim, Heeyoun Cho, Dong-Il Kim, Youngmee Jee, Haesun Yun, Keun-Young Yoo

Expression and significance of histone H3K27 demethylases in renal cell carcinoma

Open Access
Research article

Yongqing Shen, Xiaoqiang Guo, Yuejia Wang, Wei Qiu, Yanzhong Chang, Aili Zhang, Xianglin Duan

Statin use and association with colorectal cancer survival and risk: case control study with prescription data linkage

Open Access
Research article

Fatim Lakha, Evropi Theodoratou, Susan M Farrington, Albert Tenesa, Roseanne Cetnarskyj, Farhat V N Din, Mary E Porteous, Malcolm G Dunlop, Harry Campbell

MicroRNA-99a induces G1-phase cell cycle arrest and suppresses tumorigenicity in renal cell carcinoma

Open Access
Research article

Li Cui, Hua Zhou, Hu Zhao, Yaojun Zhou, Renfang Xu, Xianlin Xu, Lu Zheng, Zhong Xue, Wei Xia, Bo Zhang, Tao Ding, Yunjie Cao, Zinong Tian, Qianqian Shi, Xiaozhou He

Efficacy of psychodynamic short-term psychotherapy for depressed breast cancer patients: study protocol for a randomized controlled trial

Open Access
Study protocol

Rüdiger Zwerenz, Manfred E Beutel, Barbara H Imruck, Jörg Wiltink, Antje Haselbacher, Christian Ruckes, Heinz Schmidberger, Gerald Hoffmann, Marcus Schmidt, Uwe Köhler, Dagmar Langanke, Rolf-Dieter Kortmann, Susanne Kuhnt, Gregor Weißflog, Yvette Barthel, Katja Leuteritz, Elmar Brähler

MicroRNA-100 is a potential molecular marker of non-small cell lung cancer and functions as a tumor suppressor by targeting polo-like kinase 1

Open Access
Research article

Jing Liu, Kai-Hua Lu, Zhi-Li Liu, Ming Sun, Wei De, Zhao-Xia Wang

Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs

Open Access
Research article

Shruti U Gandhy, KyoungHyun Kim, Lesley Larsen, Rhonda J Rosengren, Stephen Safe

Breast ductal lavage for biomarker assessment in high risk women: rationale, design and methodology of a randomized phase II clinical trial with nimesulide, simvastatin and placebo

Open Access
Study protocol

Matteo Lazzeroni, Aliana Guerrieri-Gonzaga, Davide Serrano, Massimiliano Cazzaniga, Serena Mora, Chiara Casadio, Costantino Jemos, Maria Pizzamiglio, Laura Cortesi, Davide Radice, Bernardo Bonanni

Impact of partial versus whole breast radiation therapy on fatigue, perceived stress, quality of life and natural killer cell activity in women with breast cancer

Open Access
Research article

Kevin Albuquerque, Dina Tell, Philip Lobo, Linda Millbrandt, Herbert L Mathews, Linda Witek Janusek

Trends of population-based breast cancer survival in Germany and the US: Decreasing discrepancies, but persistent survival gap of elderly patients in Germany

Open Access
Research article

Bernd Holleczek, Hermann Brenner

Hepatitis B virus X protein suppresses caveolin-1 expression in hepatocellular carcinoma by regulating DNA methylation

Open Access
Research article

Jun Yan, Qian Lu, Jiahong Dong, Xiaowu Li, Kuansheng Ma, Lei Cai

Rationale of the BREAst cancer e-healTH [BREATH] multicentre randomised controlled trial: An Internet-based self-management intervention to foster adjustment after curative breast cancer by decreasing distress and increasing empowerment

Open Access
Study protocol

Sanne W van den Berg, Marieke F M Gielissen, Petronella B Ottevanger, Judith B Prins

Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis

Open Access
Research article

Anna Goc, Samith T Kochuparambil, Belal Al-Husein, Ahmad Al-Azayzih, Shuaib Mohammad, Payaningal R Somanath

Prognostic significance of 5-fluorouracil metabolism-relating enzymes and enhanced chemosensitivity to 5-fluorouracil by 5-chloro 2,4-dihydroxy-pyridine in urothelial carcinoma

Open Access
Research article

Hiroki Ide, Eiji Kikuchi, Masanori Hasegawa, Norihide Kozakai, Takeo Kosaka, Akira Miyajima, Mototsugu Oya

Tumor size as measured at initial X-ray examination, not length of bile duct stricture, predicts survival in patients with unresectable pancreatic cancer

Open Access
Research article

Henrik Forssell, Katrin Pröh, Michael Wester, Hans Krona

Evidence for different mechanisms of ‘unhooking’ for melphalan and cisplatin-induced DNA interstrand cross-links in vitroand in clinical acquired resistant tumour samples

Open Access
Research article

Victoria J Spanswick, Helen L Lowe, Claire Newton, John P Bingham, Alessia Bagnobianchi, Konstantinos Kiakos, Charles Craddock, Jonathan A Ledermann, Daniel Hochhauser, John A Hartley

PEGylated liposome IHL-305 markedly improved the survival of ovarian cancer peritoneal metastasis in mouse

Open Access
Research article

Hiroaki Konishi, Akimitsu Takagi, Akinobu Kurita, Norimasa Kaneda, Takeshi Matsuzaki

Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China

Open Access
Research article

Felipe A Castro, Jill Koshiol, Ann W Hsing, Yu-Tang Gao, Asif Rashid, Lisa W Chu, Ming-Chang Shen, Bing-Shen Wang, Tian-Qua Han, Bai-He Zhang, Shelley Niwa, Kai Yu, Hong Zhang, Stephen Chanock, Gabriella Andreotti

Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells

Open Access
Research article

Masato Eitaki, Tohru Yamamori, Shunsuke Meike, Hironobu Yasui, Osamu Inanami

Increased frequency of single base substitutions in a population of transcripts expressed in cancer cells

Open Access
Research article

Laurent Bianchetti, David Kieffer, Rémi Féderkeil, Olivier Poch

Serological identification of Tektin5 as a cancer/testis antigen and its immunogenicity

Open Access
Research article

Tadashi Hanafusa, Ali Eldib Ali Mohamed, Shohei Domae, Eiichi Nakayama, Toshiro Ono

Fractionated radiosurgery for painful spinal metastases: DOSIS - a phase II trial

Open Access
Study protocol

Matthias Guckenberger, Maria Hawkins, Michael Flentje, Reinhart A Sweeney

Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese patients compared to healthy controls

Open Access
Research article

Andreas Hillenbrand, Juliane Fassler, Nadine Huber, Pengfei Xu, Doris Henne-Bruns, Markus Templin, Hubert Schrezenmeier, Anna Maria Wolf, Uwe Knippschild

Screening of Finnish RAD51Cfounder mutations in prostate and colorectal cancer patients

Open Access
Research article

Liisa M Pelttari, Riikka Nurminen, Alexandra Gylfe, Lauri A Aaltonen, Johanna Schleutker, Heli Nevanlinna

Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt

Open Access
Research article

Selena Z Kuo, Katherine J Blair, Elham Rahimy, Alan Kiang, Eric Abhold, Jian-Bing Fan, Jessica Wang-Rodriguez, Xabier Altuna, Weg M Ongkeko

Phosphorylation of p90RSK is associated with increased response to neoadjuvant chemotherapy in ER-positive breast cancer

Open Access
Research article

Hyeong-Gon Moon, Jae Kyo Yi, Hee Sung Kim, Hea Young Lee, Kyung-Min Lee, Minju Yi, Sookyung Ahn, Hee-Chul Shin, Ji-hyun Ju, Incheol Shin, Wonshik Han, Dong-Young Noh

The role of MMP-1 in breast cancer growth and metastasis to the brain in a xenograft model

Open Access
Research article

Hui Liu, Yukinari Kato, Stephanie A Erzinger, Galina M Kiriakova, Yongzhen Qian, Diane Palmieri, Patricia S Steeg, Janet E Price

Alcohol consumption and risk of gastric cancer: a cohort study of men in Kaunas, Lithuania, with up to 30 years follow-up

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Research article

Ruta Everatt, Abdonas Tamosiunas, Irena Kuzmickiene, Dalia Virviciute, Ricardas Radisauskas, Regina Reklaitiene, Egle Milinaviciene

Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin

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Yandong Shi, Emanuela Felley-Bosco, Thomas M Marti, Katrin Orlowski, Martin Pruschy, Rolf A Stahel

Yoga for breast cancer patients and survivors: a systematic review and meta-analysis

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Holger Cramer, Silke Lange, Petra Klose, Anna Paul, Gustav Dobos

Impact of modern chemotherapy on the survival of women presenting with de novo metastatic breast cancer

Open Access
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Sumanta K Pal, Mary Dehaven, Rebecca A Nelson, Susan Onami, JoAnn Hsu, Sarah Waliany, Laura Kruper, Joanne Mortimer

Identifying specific non-attending groups in breast cancer screening - population-based registry study of participation and socio-demography

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Line Flytkjær Jensen, Anette Fischer Pedersen, Berit Andersen, Peter Vedsted

CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies

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Research article

Hongge Wang, Zhi Zhang, Sugui Han, Yujuan Lu, Fumin Feng, Juxiang Yuan

Let-7 miRNA-binding site polymorphism in the KRAS 3′UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin +/− cetuximab

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Research article

Janne B Kjersem, Tone Ikdahl, Tormod Guren, Eva Skovlund, Halfdan Sorbye, Julian Hamfjord, Per Pfeiffer, Bengt Glimelius, Christian Kersten, Hiroko Solvang, Kjell M Tveit, Elin H Kure

PTENgenomic deletion predicts prostate cancer recurrence and is associated with low AR expression and transcriptional activity

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Khalil Choucair, Joshua Ejdelman, Fadi Brimo, Armen Aprikian, Simone Chevalier, Jacques Lapointe

Association of p21 SNPs and risk of cervical cancer among Chinese women

Open Access
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Ning Wang, Shizhuo Wang, Qiao Zhang, Yanming Lu, Heng Wei, Wei Li, Shulan Zhang, Duo Yin, Yangling Ou

Quality indicators for colorectal cancer surgery and care according to patient-, tumor-, and hospital-related factors

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Research article

Simone Mathoulin-Pélissier, Yves Bécouarn, Geneviève Belleannée, Elodie Pinon, Anne Jaffré, Gaëlle Coureau, Dominique Auby, Jean-Louis Renaud-Salis, Eric Rullier

Screening for distress, the 6th vital sign: common problems in cancer outpatients over one year in usual care: associations with marital status, sex, and age

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Janine Giese-Davis, Amy Waller, Linda E Carlson, Shannon Groff, Lihong Zhong, Eric Neri, Sacha M Bachor, Jassandre Adamyk-Simpson, Kate MS Rancourt, Bernie Dunlop, Barry D Bultz

Influence of oral glutamine supplementation on survival outcomes of patients treated with concurrent chemoradiotherapy for locally advanced non-small cell lung cancer

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Research article

Erkan Topkan, Cem Parlak, Savas Topuk, Berrin Pehlivan

Assessing risk of breast cancer in an ethnically South-East Asia population (results of a multiple ethnic groups study)

Open Access
Research article

Fei Gao, David Machin, Khuan-Yew Chow, Yu-Fan Sim, Stephen W Duffy, David B Matchar, Chien-Hui Goh, Kee-Seng Chia

Mammographic density and inter-observer variability of pathologic evaluation of core biopsies among women with mammographic abnormalities

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Research article

Pietro Trocchi, Giske Ursin, Oliver Kuss, Kathrin Ruschke, Andrea Schmidt-Pokrzywniak, Hans-Jürgen Holzhausen, Thomas Löning, Christoph Thomssen, Werner Böcker, Alexander Kluttig, Andreas Stang

Tumorigenic potential of pituitary tumor transforming gene (PTTG) in vivoinvestigated using a transgenic mouse model, and effects of cross breeding with p53 (+/−) transgenic mice

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Research article

Miranda Y Fong, Hanan Farghaly, Sham S Kakar

Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients

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Research article

Wulf Siggelkow, Daniel Boehm, Susanne Gebhard, Marco Battista, Isabel Sicking, Antje Lebrecht, Christine Solbach, Birte Hellwig, Jörg Rahnenführer, Heinz Koelbl, Mathias Gehrmann, Rosemarie Marchan, Cristina Cadenas, Jan G Hengstler, Marcus Schmidt

Neurofeedback to improve neurocognitive functioning of children treated for a brain tumor: design of a randomized controlled double-blind trial

Open Access
Study protocol

Marieke A de Ruiter, Antoinette YN Schouten-Van Meeteren, Rosa van Mourik, Tieme WP Janssen, Juliette EM Greidanus, Jaap Oosterlaan, Martha A Grootenhuis

The role of chemoprevention by selective cyclooxygenase-2 inhibitors in colorectal cancer patients - a population-based study

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Research article

Yi-Hsin Yang, Yea-Huei Kao Yang, Ching-Lan Cheng, Pei-Shan Ho, Ying-Chin Ko

Hypofractionated stereotactic radiotherapy of limited brain metastases: a single-centre individualized treatment approach

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Research article

Bettina Märtens, Stefan Janssen, Martin Werner, Jörg Frühauf, Hans Christiansen, Michael Bremer, Diana Steinmann

Herpes zoster is associated with an increased risk of subsequent lymphoid malignancies - A nationwide population-based matched-control study in Taiwan

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Research article

Yi-Chang Liu, Yi-Hsin Yang, Hui-Hua Hsiao, Wen-Chi Yang, Ta-Chih Liu, Chao-Sung Chang, Ming-Yu Yang, Pai-Mei Lin, Jui-Feng Hsu, Pi-Yu Chang, Sheng-Fung Lin

PDGFRα/β and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome

Open Access
Research article

Purificacion Estevez-Garcia, Angel Castaño, Ana C Martin, Fernando Lopez-Rios, Joaquin Iglesias, Sandra Muñoz-Galván, Iker Lopez-Calderero, Sonia Molina-Pinelo, Maria D Pastor, Amancio Carnero, Luis Paz-Ares, Rocio Garcia-Carbonero

Pyloric gland adenoma of the cystic duct with malignant transformation: report of a case with a review of the literature

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Case report

Inga-Marie Schaefer, Silke Cameron, Peter Middel, Kia Homayounfar, Harald Schwörer, Michael Vieth, Lothar Veits

Prognostic role of CD133 expression in colorectal cancer: a meta-analysis

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Research article

Ke Wang, Jianjun Xu, Junshu Zhang, Jian Huang

Designing an intervention to help people with colorectal adenomas reduce their intake of red and processed meat and increase their levels of physical activity: a qualitative study

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Research article

George Dowswell, Angela Ryan, Aliki Taylor, Amanda Daley, Nick Freemantle, Matthew Brookes, Janet Jones, Richard Haslop, Chloe Grimmett, Kar-Keung Cheng, Wilson Sue

A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: design and methodological challenges

Open Access
Study protocol

Annelies Overbeek, Marleen H van den Berg, Leontien CM Kremer, Marry M van den Heuvel-Eibrink, Wim JE Tissing, Jacqueline J Loonen, Birgitta Versluys, Dorine Bresters, Gertjan JL Kaspers, Cornelis B Lambalk, Flora E van Leeuwen, Eline van Dulmen-den Broeder

Derivation and characterization of matched cell lines from primary and recurrent serous ovarian cancer

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Research article

Isabelle J Létourneau, Michael CJ Quinn, Lu-Lin Wang, Lise Portelance, Katia Y Caceres, Louis Cyr, Nathalie Delvoye, Liliane Meunier, Manon de Ladurantaye, Zhen Shen, Suzanna L Arcand, Patricia N Tonin, Diane M Provencher, Anne-Marie Mes-Masson

RON is not a prognostic marker for resectable pancreatic cancer

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Research article

Carole M Tactacan, David K Chang, Mark J Cowley, Emily S Humphrey, Jianmin Wu, Anthony J Gill, Angela Chou, Katia Nones, Sean M Grimmond, Robert L Sutherland, Andrew V Biankin, Roger J Daly

Risk factors for nasal malignancies in German men: the South-German Nasal cancer study

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Research article

Eberhard M Greiser, Karin Halina Greiser, Wolfgang Ahrens, Rudolf Hagen, Roland Lazszig, Heinz Maier, Bernhard Schick, Hans Peter Zenner

The prognostic impact of epidermal growth factor receptor in patients with metastatic gastric cancer

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Research article

Akin Atmaca, Dominique Werner, Claudia Pauligk, Kristina Steinmetz, Ralph Wirtz, Hans-Michael Altmannsberger, Elke Jäger, Salah-Eddin Al-Batran

CanPrevent: a telephone-delivered intervention to reduce multiple behavioural risk factors for colorectal cancer

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Research article

Anna L Hawkes, Tania A Patrao, Anita Green, Joanne F Aitken

Phase I study of imatinib, cisplatin and 5-fluoruracil or capecitabine in advanced esophageal and gastric adenocarcinoma

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Research article

Martina Mayr, Karen Becker, Nadine Schulte, Sebastian Belle, Ralf Hofheinz, Annekatrin Krause, Roland M Schmid, Christoph Röcken, Matthias P Ebert

Microtubule S-glutathionylation as a potential approach for antimitotic agents

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Research article

Wei Chen, Teresa Seefeldt, Alan Young, Xiaoying Zhang, Yong Zhao, John Ruffolo, Radhey S Kaushik, Xiangming Guan

Correlation between Slug transcription factor and miR-221 in MDA-MB-231 breast cancer cells

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Research article

Elisabetta Lambertini, Andrea Lolli, Federica Vezzali, Letizia Penolazzi, Roberto Gambari, Roberta Piva

Decentral gene expression analysis: analytical validation of the Endopredict genomic multianalyte breast cancer prognosis test

Open Access
Technical advance

Ralf Kronenwett, Kerstin Bohmann, Judith Prinzler, Bruno V Sinn, Franziska Haufe, Claudia Roth, Manuela Averdick, Tanja Ropers, Claudia Windbergs, Jan C Brase, Karsten E Weber, Karin Fisch, Berit M Müller, Marcus Schmidt, Martin Filipits, Peter Dubsky, Christoph Petry, Manfred Dietel, Carsten Denkert

Application of the Western-based adjuvant online model to Korean colon cancer patients; a single institution experience

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Research article

Minkyu Jung, Geon Woo Kim, Inkyung Jung, Joong Bae Ahn, Jae Kyung Roh, Sun Young Rha, Hyun Cheol Chung, Nam Kyu Kim, Tae Il Kim, Sang Joon Shin

Clinical procedure for colon carcinoma tissue sampling directly affects the cancer marker-capacity of VEGF family members

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Research article

Sarah Pringels, Nancy Van Damme, Bram De Craene, Piet Pattyn, Wim Ceelen, Marc Peeters, Johan Grooten

The Alberta moving beyond breast cancer (AMBER) cohort study: a prospective study of physical activity and health-related fitness in breast cancer survivors

Open Access
Study protocol

Kerry S Courneya, Jeff K Vallance, S Nicole Culos-Reed, Margaret L McNeely, Gordon J Bell, John R Mackey, Yutaka Yasui, Yan Yuan, Charles E Matthews, David CW Lau, Diane Cook, Christine M Friedenreich

The impact of physical activity on fatigue and quality of life in lung cancer patients: a randomised controlled trial protocol

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Study protocol

Haryana M Dhillon, Hidde P van der Ploeg, Melanie L Bell, Michael Boyer, Stephen Clarke, Janette Vardy

Patient-tailored modulation of the immune system may revolutionize future lung cancer treatment

Open Access
Review

Marlies E Heuvers, Joachim G Aerts, Robin Cornelissen, Harry Groen, Henk C Hoogsteden, Joost P Hegmans

Impact of stem cell marker expression on recurrence of TACE-treated hepatocellular carcinoma post liver transplantation

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Research article

Zhen Zeng, Jinyu Ren, Maura O’Neil, Jie Zhao, Brian Bridges, Josiah Cox, Bashar Abdulkarim, Timothy M Schmitt, Sean C Kumer, Steven A Weinman

Occupational exposure to asbestos and lung cancer in men: evidence from a population-based case-control study in eight Canadian provinces

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Research article

Paul J Villeneuve, Marie-Élise Parent, Shelley A Harris, Kenneth C Johnson

SNP microarray analyses reveal copy number alterations and progressive genome reorganization during tumor development in SVT/t driven mice breast cancer

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Research article

Christoph Standfuß, Heike Pospisil, Andreas Klein

LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer

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Research article

Aika Matsunoki, Kazuyuki Kawakami, Masanori Kotake, Mami Kaneko, Hirotaka Kitamura, Akishi Ooi, Go Watanabe, Toshinari Minamoto

Normal tissue complication probability model parameter estimation for xerostomia in head and neck cancer patients based on scintigraphy and quality of life assessments

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Research article

Tsair-Fwu Lee, Pei-Ju Chao, Hung-Yu Wang, Hsuan-Chih Hsu, PaoShu Chang, Wen-Cheng Chen

Reduced CYP2D6 function is associated with gefitinib-induced rash in patients with non-small cell lung cancer

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Research article

Tomohiro Suzumura, Tatsuo Kimura, Shinzoh Kudoh, Kanako Umekawa, Misato Nagata, Kuniomi Matsuura, Hidenori Tanaka, Shigeki Mitsuoka, Naruo Yoshimura, Yukimi Kira, Toshiyuki Nakai, Kazuto Hirata

Wnt/β-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia

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Research article

Stephany Corrêa, Renata Binato, Bárbara Du Rocher, Morgana TL Castelo-Branco, Luciana Pizzatti, Eliana Abdelhay

Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway

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Research article

Katie Twigger, Victoria Roulstone, Joan Kyula, Eleni M Karapanagiotou, Konstantinos N Syrigos, Richard Morgan, Christine White, Shreerang Bhide, Gerard Nuovo, Matt Coffey, Brad Thompson, Adel Jebar, Fiona Errington, Alan A Melcher, Richard G Vile, Hardev S Pandha, Kevin J Harrington

A case–control study on the effect of Apolipoprotein E genotypes on gastric cancer risk and progression

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Research article

Emma De Feo, Benedetto Simone, Roberto Persiani, Ferdinando Cananzi, Alberto Biondi, Dario Arzani, Rosarita Amore, Domenico D’Ugo, Gualtiero Ricciardi, Stefania Boccia

Testing of human papillomavirus in lung cancer and non-tumor lung tissue

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Research article

Antonella Galvan, Sara Noci, Francesca Taverna, Claudia Lombardo, Silvia Franceschi, Ugo Pastorino, Tommaso A Dragani

Spatial morphological and molecular differences within solid tumors may contribute to the failure of vascular disruptive agent treatments

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Research article

Linh Nguyen, Theodora Fifis, Caterina Malcontenti-Wilson, Lie Sam Chan, Patricia Nunes Luiza Costa, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Christopher Christophi

Germline truncating-mutations in BRCA1 and MSH6 in a patient with early onset endometrial cancer

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Case report

Karin Kast, Teresa M Neuhann, Heike Görgens, Kerstin Becker, Katja Keller, Barbara Klink, Daniela Aust, Wolfgang Distler, Evelin Schröck, Hans K Schackert

Profound tumor-specific Th2 bias in patients with malignant glioma

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Research article

Shinji Shimato, Lisa M Maier, Richard Maier, Jeffrey N Bruce, Richard CE Anderson, David E Anderson

Alterations in epidermal growth factor receptors 1 and 2 in esophageal squamous cell carcinomas

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Research article

Isabela Martins Gonzaga, Sheila Coelho Soares-Lima, Paulo Thiago Souza de Santos, Tania Cristina Moita Blanco, Bruno Souza Bianchi de Reis, Danielle Carvalho Quintella, Ivanir Martins de Oliveira, Paulo Antonio Silvestre de Faria, Cleber Dario Pinto Kruel, Nelson Adami Andreollo, Tatiana Almeida de Simão, Luis Felipe Ribeiro Pinto

Comparison of tai chi vs. strength training for fall prevention among female cancer survivors: study protocol for the GET FIT trial

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Study protocol

Kerri M Winters-Stone, Fuzhong Li, Fay Horak, Shiuh-Wen Luoh, Jill A Bennett, Lillian Nail, Nathan Dieckmann

GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers

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Research article

Sylvia Hartmann, Claudio Agostinelli, Jürgen Diener, Claudia Döring, Stefano Fanti, Pier Luigi Zinzani, Andrea Gallamini, Lothar Bergmann, Stefano Pileri, Martin-Leo Hansmann

The clinical significance of Psoriasin for non-small cell lung cancer patients and its biological impact on lung cancer cell functions

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Research article

Mu Hu, Lin Ye, Fiona Ruge, Xiuyi Zhi, Lijian Zhang, Wen G Jiang

Role of emmprin in endometrial cancer

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Research article

Keiichiro Nakamura, Junichi Kodama, Atsushi Hongo, Yuji Hiramatsu

Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells

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Research article

Anne-Laure Papa, Sudipta Basu, Poulomi Sengupta, Deboshri Banerjee, Shiladitya Sengupta, Rania Harfouche

The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition

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Research article

Chander Peddaboina, Daniel Jupiter, Steven Fletcher, Jeremy L Yap, Arun Rai, Richard P Tobin, Weihua Jiang, Philip Rascoe, M Karen Newell Rogers, W Roy Smythe, Xiaobo Cao

Epidermal growth factor receptor (EGFR) mutations and expression in squamous cell carcinoma of the esophagus in central Asia

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Research article

Behnoush Abedi-Ardekani, Nazir Ahmad Dar, Mohammad Muzaffar Mir, Showkat Ahmad Zargar, M Muqbool Lone, Ghyslaine Martel-Planche, Stéphanie Villar, Mounia Mounawar, Farrokh Saidi, Reza Malekzadeh, Pierre Hainaut

Development and validation of a questionnaire to assess delay in treatment for breast cancer

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Research article

Karla Unger-Saldaña, Ingris Peláez-Ballestas, Claudia Infante-Castañeda

Peri-operative chemotherapy in the management of resectable colorectal cancer pulmonary metastases

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Research article

Eliza A Hawkes, George Ladas, David Cunningham, Andrew G Nicholson, Katharina Wassilew, Yolanda Barbachano, Gihan Ratnayake, Sheela Rao, Ian Chau

A systems biology approach to the global analysis of transcription factors in colorectal cancer

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Research article

Meeta P Pradhan, Nagendra KA Prasad, Mathew J Palakal

Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla

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Research article

Sarah J Storr, Abed M Zaitoun, Arvind Arora, Lindy G Durrant, Dileep N Lobo, Srinivasan Madhusudan, Stewart G Martin

Doxorubicin-enriched, ALDHbr mouse breast cancer stem cells are treatable to oncolytic herpes simplex virus type 1

Open Access
Research article

Xiufen Zhuang, Wen Zhang, Yatong Chen, Xiangping Han, Jie Li, Yu Zhang, Youhui Zhang, Shuren Zhang, Binlei Liu

Blood vessel hyperpermeability and pathophysiology in human tumour xenograft models of breast cancer: a comparison of ectopic and orthotopic tumours

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Research article

Karyn S Ho, Peter C Poon, Shawn C Owen, Molly S Shoichet

“Iron-saturated” bovine lactoferrin improves the chemotherapeutic effects of tamoxifen in the treatment of basal-like breast cancer in mice

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Research article

Xueying Sun, Ruohan Jiang, Aneta Przepiorski, Shiva Reddy, Kate P Palmano, Geoffrey W Krissansen

Statins and the risk of gastric cancer in diabetes patients

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Research article

Jeeyun Lee, Soo Hyeon Lee, Kyu Yeon Hur, Sook Young Woo, Sun Woo Kim, Won Ki Kang

Overexpression of SERBP1 (Plasminogen activator inhibitor 1 RNA binding protein) in human breast cancer is correlated with favourable prognosis

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Research article

Nuran Bektas Serce, Andreas Boesl, Irina Klaman, Sonja von Serényi, Erik Noetzel, Michael F Press, Arno Dimmler, Arndt Hartmann, Jalid Sehouli, Ruth Knuechel, Matthias W Beckmann, Peter A Fasching, Edgar Dahl

Detection methods predict differences in biology and survival in breast cancer patients

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Research article

Maximino Redondo, Rafael Funez, Francisco Medina-Cano, Isabel Rodrigo, Mercedes Acebal, Teresa Tellez, M Jose Roldan, M Luisa Hortas, Ana Bellinvia, Teresa Pereda, Laia Domingo, María Morales-Suarez Varela, Maria Sala, Antonio Rueda

Molecular pathways undergoing dramatic transcriptomic changes during tumor development in the human colon

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Research article

Rosalia Maglietta, Vania Cosma Liuzzi, Elisa Cattaneo, Endre Laczko, Ada Piepoli, Anna Panza, Massimo Carella, Orazio Palumbo, Teresa Staiano, Federico Buffoli, Angelo Andriulli, Giancarlo Marra, Nicola Ancona

Functioning glucagonoma associated with primary hyperparathyroidism: multiple endocrine neoplasia type 1 or incidental association?

Open Access
Case report

Enrico Erdas, Nicola Aste, Luca Pilloni, Angelo Nicolosi, Sergio Licheri, Antonello Cappai, Marco Mastinu, Filomena Cetani, Elena Pardi, Stefano Mariotti, Mariano Pomata

Survivin selective inhibitor YM155 induce apoptosis in SK-NEP-1 Wilms tumor cells

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Research article

Yan-Fang Tao, Jun Lu, Xiao-Juan Du, Li-Chao Sun, Xuan Zhao, Liang Peng, Lan Cao, Pei-Fang Xiao, Li Pang, Dong Wu, Na Wang, Xing Feng, Yan-Hong Li, Jian Ni, Jian Wang, Jian Pan

α-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial

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Research article

Yasuto Akiyama, Chie Oshita, Akiko Kume, Akira Iizuka, Haruo Miyata, Masaru Komiyama, Tadashi Ashizawa, Mika Yagoto, Yoshiaki Abe, Koichi Mitsuya, Reiko Watanabe, Takashi Sugino, Ken Yamaguchi, Yoko Nakasu

Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer

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Research article

Casina WS Kan, Michael A Hahn, Gregory B Gard, Jayne Maidens, Jung Yoon Huh, Deborah J Marsh, Viive M Howell

Case–control study of HLA-G promoter methylation status, HPV infection and cervical neoplasia in Curitiba, Brazil: a pilot analysis

Open Access
Research article

Anna Gillio-Tos, Maria da Graça Bicalho, Valentina Fiano, Chiara Grasso, Valentina Tarallo, Laura De Marco, Morena Trevisan, MarinaBarbaradeSousa Xavier, Renata Slowik, Newton S Carvalho, Carlos A Maestri, Hadriano M Lacerda, Daniela Zugna, Lorenzo Richiardi, Franco Merletti

PCA3 noncoding RNA is involved in the control of prostate-cancer cell survival and modulates androgen receptor signaling

Open Access
Research article

Luciana Bueno Ferreira, Antonio Palumbo, Kivvi Duarte de Mello, Cinthya Sternberg, Mauricio S Caetano, Felipe Leite de Oliveira, Adriana Freitas Neves, Luiz Eurico Nasciutti, Luiz Ricardo Goulart, Etel Rodrigues Pereira Gimba

Histone demethylase GASC1 - a potential prognostic and predictive marker in invasive breast cancer

Open Access
Research article

Bozena Berdel, Kaisa Nieminen, Ylermi Soini, Maria Tengström, Marjo Malinen, Veli-Matti Kosma, Jorma J Palvimo, Arto Mannermaa

Salvage chemoradiotherapy after primary chemotherapy for locally advanced pancreatic cancer: a single-institution retrospective analysis

Open Access
Research article

Hiroshi Mayahara, Yoshinori Ito, Chigusa Morizane, Hideki Ueno, Takuji Okusaka, Shunsuke Kondo, Naoya Murakami, Madoka Morota, Minako Sumi, Jun Itami

The clinical features of papillary thyroid cancer in Hashimoto’s thyroiditis patients from an area with a high prevalence of Hashimoto’s disease

Open Access
Research article

Ling Zhang, Hui Li, Qing-hai Ji, Yong-xue Zhu, Zhuo-ying Wang, Yu Wang, Cai-ping Huang, Qiang Shen, Duan-shu Li, Yi Wu

Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case–control study

Open Access
Research article

Peng Zhao, Lin Zhao, Peng Zou, Ailin Lu, Ning Liu, Wei Yan, Chunsheng Kang, Zhen Fu, Yongping You, Tao Jiang

Benefits of hyperthermic intraperitoneal chemotherapy for patients with serosal invasion in gastric cancer: a meta-analysis of the randomized controlled trials

Open Access
Research article

Jingxu Sun, Yongxi Song, Zhenning Wang, Peng Gao, Xiaowan Chen, Yingying Xu, Jiwang Liang, Huimian Xu

Immediate in vivo target-specific cancer cell death after near infrared photoimmunotherapy

Open Access
Research article

Makoto Mitsunaga, Takahito Nakajima, Kohei Sano, Gabriela Kramer-Marek, Peter L Choyke, Hisataka Kobayashi

Characterization of genetic rearrangements in esophageal squamous carcinoma cell lines by a combination of M-FISH and array-CGH: further confirmation of some split genomic regions in primary tumors

Open Access
Research article

Jia-Jie Hao, Zhi-Zhou Shi, Zhi-Xin Zhao, Yu Zhang, Ting Gong, Chun-Xiang Li, Ting Zhan, Yan Cai, Jin-Tang Dong, Song-Bin Fu, Qi-Min Zhan, Ming-Rong Wang

CHD1L Protein is overexpressed in human ovarian carcinomas and is a novel predictive biomarker for patients survival

Open Access
Research article

Wei-Peng He, Juan Zhou, Mu-Yan Cai, Xiang-Shen Xiao, Yi-Ji Liao, Hsiang-Fu Kung, Xin-Yuan Guan, Dan Xie, Guo-Fen Yang

Exercise and nutrition for head and neck cancer patients: a patient oriented, clinic-supported randomized controlled trial

Open Access
Study protocol

Lauren C Capozzi, Harold Lau, Raylene A Reimer, Margaret McNeely, Janine Giese-Davis, S Nicole Culos-Reed

Overexpression of Snail is associated with lymph node metastasis and poor prognosis in patients with gastric cancer

Open Access
Research article

Na Ri Shin, Eun Hui Jeong, Chang In Choi, Hyun Jung Moon, Chae Hwa Kwon, In Sun Chu, Gwang Ha Kim, Tae Yong Jeon, Dae Hwan Kim, Jae Hyuk Lee, Do Youn Park

The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714predict adverse outcome for breast cancer patients

Open Access
Research article

Eydis Th Gudmundsdottir, Rosa B Barkardottir, Adalgeir Arason, Haukur Gunnarsson, Laufey Th Amundadottir, Bjarni A Agnarsson, Oskar Th Johannsson, Inga Reynisdottir

Autophagy-independent enhancing effects of Beclin 1 on cytotoxicity of ovarian cancer cells mediated by proteasome inhibitors

Open Access
Research article

Chuan Liu, Xu Yan, Hua-Qin Wang, Yan-Yan Gao, Juanjuan Liu, Zhenhua Hu, Dawo Liu, Jian Gao, Bei Lin

Androgen receptors and serum testosterone levels identify different subsets of postmenopausal breast cancers

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Research article

Giorgio Secreto, Elisabetta Venturelli, Elisabetta Meneghini, Maria Luisa Carcangiu, Biagio Paolini, Roberto Agresti, Cristina Pellitteri, Franco Berrino, Massimo Gion, Patrizia Cogliati, Giuseppina Saragò, Andrea Micheli

External validation of the Bayesian Estimated Tools for Survival (BETS) models in patients with surgically treated skeletal metastases

Open Access
Research article

Jonathan Agner Forsberg, Rikard Wedin, Henrik CF Bauer, Bjarne H Hansen, Minna Laitinen, Clement S Trovik, Johnny Ø Keller, Patrick J Boland, John H Healey

Prognostic value of stromal and epithelial periostin expression in human prostate cancer: correlation with clinical pathological features and the risk of biochemical relapse or death

Open Access
Research article

Pier Vitale Nuzzo, Alessandra Rubagotti, Linda Zinoli, Francesco Ricci, Sandra Salvi, Simona Boccardo, Francesco Boccardo

Intraoperative Electron Radiation Therapy (IOERT) in the management of locally recurrent rectal cancer

Open Access
Research article

Falk Roeder, Joerg-Michael Goetz, Gregor Habl, Marc Bischof, Robert Krempien, Markus W Buechler, Frank W Hensley, Peter E Huber, Juergen Weitz, Juergen Debus

Enhanced expression of G-protein coupled estrogen receptor (GPER/GPR30) in lung cancer

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Research article

Venkatakrishna Rao Jala, Brandie N Radde, Bodduluri Haribabu, Carolyn M Klinge

Genotypic and phenotypic analysis of familial male breast cancer shows under representation of the HER2 and basal subtypes in BRCA-associated carcinomas

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Research article

Siddhartha Deb, Nicholas Jene, kConFab investigators, Stephen B Fox

Preclinical evaluation of Gd-DTPA and gadomelitol as contrast agents in DCE-MRI of cervical carcinoma interstitial fluid pressure

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Research article

Tord Hompland, Christine Ellingsen, Einar K Rofstad

Aberrant methylation of the M-type phospholipase A2 receptor gene in leukemic cells

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Research article

Mario Menschikowski, Uwe Platzbecker, Albert Hagelgans, Margot Vogel, Christian Thiede, Claudia Schönefeldt, Renate Lehnert, Graeme Eisenhofer, Gabriele Siegert

Dynamics of circulating endothelial cells and endothelial progenitor cells in breast cancer patients receiving cytotoxic chemotherapy

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Research article

Yu-Hsuan Kuo, Ching-Hung Lin, Wen-Yi Shau, Te-Jung Chen, Shih-Hung Yang, Shu-Min Huang, Chun Hsu, Yen-Shen Lu, Ann-Lii Cheng

Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism

Open Access
Research article

Mamduh Khateb, Nili Ruimi, Hazem Khamisie, Yousef Najajreh, Afsar Mian, Anna Metodieva, Martin Ruthardt, Jamal Mahajna

Alternative dosing of dual PI3K and MEK inhibition in cancer therapy

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Elina Jokinen, Niina Laurila, Jussi P Koivunen

Colon cancer molecular subtypes identified by expression profiling and associatedto stroma, mucinous type and different clinical behavior

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Laurien M Buffart, Jannique GZ van Uffelen, Ingrid I Riphagen, Johannes Brug, Willem van Mechelen, Wendy J Brown, Mai JM Chinapaw

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Peir-In Liang, Wei-Ming Li, Yu-Hui Wang, Ting-Feng Wu, Wen-Ren Wu, Alex C Liao, Kun-Hung Shen, Yu-Ching Wei, Chung-Hsi Hsing, Yow-Ling Shiue, Hsuan-Ying Huang, Han-Ping Hsu, Li-Tzon Chen, Ching-Yih Lin, Chein Tai, Chun-Mao Lin, Chien-Feng Li

Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study

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Nifang Niu, Daniel J Schaid, Ryan P Abo, Krishna Kalari, Brooke L Fridley, Qiping Feng, Gregory Jenkins, Anthony Batzler, Abra G Brisbin, Julie M Cunningham, Liang Li, Zhifu Sun, Ping Yang, Liewei Wang

The association of DNA Repair with breast cancer risk in women. A comparative observational study

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Jaime Matta, Miguel Echenique, Esperanza Negron, Luisa Morales, Wanda Vargas, Felipe Sánchez Gaetan, Eduardo Ramírez Lizardi, Aníbal Torres, Jose Ortiz Rosado, Guillermo Bolaños, Juan González Cruz, Joaquín Laboy, Ricardo Barnes, Santos Santiago Medina, Ángel Romero, Rosendo Martinez, Julie Dutil, Erick Suarez, Carolina Alvarez-Garriga, Manuel Bayona

Impact of organised cervical screening on cervical cancer incidence and mortality in migrant women in Australia

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Nayyereh Aminisani, Bruce K Armstrong, Sam Egger, Karen Canfell

Systematic review with meta-analysis of the epidemiological evidence relating FEV1decline to lung cancer risk

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John S Fry, Jan S Hamling, Peter N Lee

Unique perception of clinical trials by Korean cancer patients

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Su Jin Lee, Lee Chun Park, Jeeyun Lee, Seonwoo Kim, Moon Ki Choi, Jung Yong Hong, Sylvia Park, Chi Hoon Maeng, Wonjin Chang, Young Saing Kim, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Young Suk Park

Up-regulated expression of l-caldesmon associated with malignancy of colorectal cancer

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Kyung-Hee Kim, Seung-Gu Yeo, Won Ki Kim, Dae Yong Kim, Hyun Yang Yeo, Jun Pyu Hong, Hee Jin Chang, Ji Won Park, Sun Young Kim, Byung Chang Kim, Byong Chul Yoo

Development of a gene therapy strategy to target hepatocellular carcinoma based inhibition of protein phosphatase 2A using the α-fetoprotein promoter enhancer and pgk promoter: an in vitro and in vivo study

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Wei Li, Dao-Ming Li, Kai Chen, Zheng Chen, Yang Zong, Hong Yin, Ze-Kuan Xu, Yi Zhu, Fei-Ran Gong, Min Tao

Steroid hormone receptor expression in ovarian cancer: progesterone receptor B as prognostic marker for patient survival

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Miriam Lenhard, Lennerová Tereza, Sabine Heublein, Nina Ditsch, Isabelle Himsl, Doris Mayr, Klaus Friese, Udo Jeschke

Fatal case of sorafenib-associated idiosyncratic hepatotoxicity in the adjuvant treatment of a patient with renal cell carcinoma

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BP Fairfax, S Pratap, ISD Roberts, J Collier, R Kaplan, AM Meade, AW Ritchie, T Eisen, VM Macaulay, A Protheroe

Stat3 is a positive regulator of gap junctional intercellular communication in cultured, human lung carcinoma cells

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Mulu Geletu, Rozanne Arulanandam, Samantha Greer, Aaron Trotman-Grant, Evangelia Tomai, Leda Raptis

The role of brevican in glioma: promoting tumor cell motility in vitro and in vivo

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Renquan Lu, Chengsheng Wu, Lin Guo, Yingchao Liu, Wei Mo, Huijie Wang, Jianbo Ding, Eric T Wong, Min Yu

Epidemiology and outcomes of previously undiagnosed diabetes in older women with breast cancer: an observational cohort study based on SEER-Medicare

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Robert I Griffiths, Mark D Danese, Michelle L Gleeson, José M Valderas

Arachidonic acid and cancer risk: a systematic review of observational studies

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Mai Sakai, Saki Kakutani, Chika Horikawa, Hisanori Tokuda, Hiroshi Kawashima, Hiroshi Shibata, Hitomi Okubo, Satoshi Sasaki

PTPRZ1 regulates calmodulin phosphorylation and tumor progression in small-cell lung carcinoma

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Hideki Makinoshima, Genichiro Ishii, Motohiro Kojima, Satoshi Fujii, Youichi Higuchi, Takeshi Kuwata, Atsushi Ochiai

Disseminated tumor cells as selection marker and monitoring tool for secondary adjuvant treatment in early breast cancer. Descriptive results from an intervention study

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Marit Synnestvedt, Elin Borgen, Erik Wist, Gro Wiedswang, Kjetil Weyde, Terje Risberg, Christian Kersten, Ingvil Mjaaland, Lise Vindi, Cecilie Schirmer, Jahn Martin Nesland, Bjørn Naume

Integrative oncology for breast cancer patients: introduction of an expert-based model

Open Access
Debate

Gustav J Dobos, Petra Voiss, Ilka Schwidde, Kyung-Eun Choi, Anna Paul, Barbara Kirschbaum, Felix J Saha, Sherko Kuemmel

Mucin-1 and its relation to grade, stage and survival in ovarian carcinoma patients

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Verena Engelstaedter, Sabine Heublein, Anamur Lan Schumacher, Miriam Lenhard, Helen Engelstaedter, Ulrich Andergassen, Margit Guenthner-Biller, Christina Kuhn, Brigitte Rack, Markus Kupka, Doris Mayr, Udo Jeschke

The STAR trial protocol: a randomised multi-stage phase II/III study of Sunitinib comparing temporary cessation with allowing continuation, at the time of maximal radiological response, in the first-line treatment of locally advanced/metastatic Renal Cancer

Open Access
Study protocol

Fiona J Collinson, Walter M Gregory, Chris McCabe, Helen Howard, Catherine Lowe, DrBarbara Potrata, Sandy Tubeuf, Pat Hanlon, Lucy McParland, T Wah, Peter J Selby, Jenny Hewison, Julia Brown, Janet Brown

Snake venom toxin from vipera lebetina turanicainduces apoptosis of colon cancer cells via upregulation of ROS- and JNK-mediated death receptor expression

Open Access
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Mi Hee Park, MiRan Jo, Dohee Won, Ho Sueb Song, Sang Bae Han, Min Jong Song, Jin Tae Hong

Can treatment with Cocculine improve the control of chemotherapy-induced emesis in early breast cancer patients? A randomized, multi-centered, double-blind, placebo-controlled Phase III trial

Open Access
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David Pérol, Jocelyne Provençal, Anne-claire Hardy-Bessard, David Coeffic, Jean-Phillipe Jacquin, Cécile Agostini, Thomas Bachelot, Jean-Paul Guastalla, Xavier Pivot, Jean-Pierre Martin, Agathe Bajard, Isabelle Ray-Coquard

Tumor suppressor BLU inhibits proliferation of nasopharyngeal carcinoma cells by regulation of cell cycle, c-Jun N-terminal kinase and the cyclin D1 promoter

Open Access
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Xiangning Zhang, Hui Liu, Binbin Li, Peichun Huang, Jianyong Shao, Zhiwei He

The association between MTHFR 677C>T polymorphism and cervical cancer: evidence from a meta-analysis

Open Access
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Qiang Mei, Daijun Zhou, Jinyu Gao, Shu Shen, Jinlin Wu, Linna Guo, Zhiqing Liang

Re-directed T cells for the treatment of fibroblast activation protein (FAP)-positive malignant pleural mesothelioma (FAPME-1)

Open Access
Study protocol

Ulf Petrausch, Petra C Schuberth, Christian Hagedorn, Alex Soltermann, Sandra Tomaszek, Rolf Stahel, Walter Weder, Christoph Renner

Tissue Tolerable Plasma (TTP) induces apoptosis in pancreatic cancer cells in vitro and in vivo

Open Access
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Lars Ivo Partecke, Katja Evert, Jan Haugk, Friderike Doering, Lars Normann, Stephan Diedrich, Frank-Ulrich Weiss, Matthias Evert, Nils Olaf Huebner, Cristin Guenther, Claus Dieter Heidecke, Axel Kramer, René Bussiahn, Klaus-Dieter Weltmann, Onur Pati, Claudia Bender, Wolfram von Bernstorff

Pancreatic cancer circulating tumour cells express a cell motility gene signature that predicts survival after surgery

Open Access
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Gregory Sergeant, Rudy van Eijsden, Tania Roskams, Victor Van Duppen, Baki Topal

Neural protein gamma-synuclein interacting with androgen receptor promotes human prostate cancer progression

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Neu im Fachgebiet Onkologie

Adnexläsion zufällig im CT entdeckt? Die Befundung fällt selbst Fachleuten schwer!

06.03.2026
Gynäkologische Radiologie
Nachrichten

Ist eine Läsion benigne oder maligne? Und um welche Art handelt es sich genau? Ergebnisse einer kleinen US-Studie zu inzidentellen CT-Befunden sprechen dafür, dass sich auch Expertinnen und Experten bei Adnex-Auffälligkeiten häufig uneins sind – und einige maligne Läsionen verkennen.

Real-World Daten bestätigen Nivolumab bei Kopf-Hals-Tumoren

06.03.2026
DKK 2026
Kongressbericht

In der nicht-interventionellen Real-World-Studie HANNA wurde Nivolumab bei Menschen mit rezidiviertem oder metastasiertem Plattenepithelkarzinom der Kopf-Hals-Region in verschiedenen Therapielinien geprüft. Ein Kollege präsentierte auf dem diesjährigen Krebskongress in Berlin die finalen Daten.

Wie Mikrobiom und Komedikation Immuntherapien beeinflussen

06.03.2026
DKK 2026
Kongressbericht

Die Effektivität von Checkpoint-Inhibitoren wird unter anderem durch das Mikrobiom und Komedikationen beeinflusst. Wie Ballaststoffe wirken und welche Medikamente man nicht zusammen mit der Immuntherapie geben sollte, zeigten eine Kollegin und ein Kollege auf dem DKK in Berlin auf.

Mehr molekulare Diagnostik bei Krebs ist nicht immer besser

06.03.2026
DKK 2026
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Neue molekularpathologische Methoden erhöhen die diagnostische Sensitivität bei Tumorerkrankungen. Aber verfeinert ein stetiges Mehr an molekularer Diagnostik auch die therapeutische Präzision? Diese Frage wurde im Rahmen des Deutschen Krebskongresses (DKK) 2026 in Berlin diskutiert.

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Radiologie-Assistent bereitet Frau für CT vor/© Peakstock/stock.adobe.com (Symbolbild mit Fotomodellen), Plattenepithelkarzinom/© Springer Medizin Verlag GmbH, Frau bereitet Müsli auf Waage zu/© DragonImages / Stock.adobe.com (Symbolbild mit Fotomodell), 3D Illustration einer DNA Sequenzierung/© undefined / Getty Images / iStock