BMC Cancer

Feasibility and acceptability of combining cognitive behavioural therapy techniques with swallowing therapy in head and neck cancer dysphagia

• Open Access
• Research article

J. M. Patterson, M. Fay, C. Exley, E. McColl, M. Breckons, V. Deary

Identification of fluorescence in situ hybridization assay markers for prediction of disease progression in prostate cancer patients on active surveillance

• Open Access
• Research article

Katerina Pestova, Adam J. Koch, Charles P. Quesenberry, Jun Shan, Ying Zhang, Amethyst D. Leimpeter, Beth Blondin, Svetlana Sitailo, Lela Buckingham, Jing Du, Huixin Fei, Stephen K. Van Den Eeden

Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool

• Open Access
• Research article

Pablo Cabezas-Sainz, Jorge Guerra-Varela, María J. Carreira, Javier Mariscal, María Roel, Juan A. Rubiolo, Andrés A. Sciara, Miguel Abal, Luis M. Botana, Rafael López, Laura Sánchez

Heterogeneity of PD-L1 expression in primary tumors and paired lymph node metastases of triple negative breast cancer

• Open Access
• Research article

Ming Li, Anqi Li, Shuling Zhou, Yan Xu, Yaoxing Xiao, Rui Bi, Wentao Yang

An inflammation-based cumulative prognostic score system in patients with diffuse large B cell lymphoma in rituximab era

• Open Access
• Research article

Feifei Sun, Jia Zhu, Suying Lu, Zijun Zhen, Juan Wang, Junting Huang, Zonghui Ding, Musheng Zeng, Xiaofei Sun

Differential efficacy of cisplatin plus pemetrexed between L858R and Del-19 in advanced EGFR-mutant non-squamous non-small cell lung cancer

• Open Access
• Research article

Toshihiko Kaneda, Hiroshige Yoshioka, Motohiro Tamiya, Akihiro Tamiya, Akito Hata, Asukaka Okada, Takashi Niwa, Takayuki Shiroyama, Masaki Kanazu, Tadashi Ishida, Nobuyuki Katakami

Pathological and molecular diagnosis of bilateral inguinal lymph nodes metastases from low-grade endometrial adenocarcinoma: a case report with review of the literature

• Open Access
• Case report

Anna Myriam Perrone, Giulia Girolimetti, Simona Cima, Ivana Kurelac, Alessandra Livi, Giacomo Caprara, Donatella Santini, Paolo Castellucci, Alessio Giuseppe Morganti, Giuseppe Gasparre, Pierandrea De Iaco

Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations

• Open Access
• Research article

René Böttcher, Charlotte F. Kweldam, Julie Livingstone, Emilie Lalonde, Takafumi N. Yamaguchi, Vincent Huang, Fouad Yousif, Michael Fraser, Robert G. Bristow, Theodorus van der Kwast, Paul C. Boutros, Guido Jenster, Geert J. L. H. van Leenders

Chemokine CCL27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the Epstein-Barr virus capsid antigen-specific IgA seropositive population

• Open Access
• Research article

Min-jie Mao, Ning Xue, Xue-ping Wang, Pei-dong Chi, Yi-jun Liu, Qi Huang, Shu-qin Dai, Wan-li Liu

Crizotinib in patients with anaplastic lymphoma kinase-positive advanced non-small cell lung cancer versus chemotherapy as a first-line treatment

• Open Access
• Research article

Jianya Zhou, Jing Zheng, Xiaochen Zhang, Jing Zhao, Yanping Zhu, Qian Shen, Yuehong Wang, Ke Sun, Zeying Zhang, Zhijie Pan, Yihong Shen, Jianying Zhou

Sidedness and TP53 mutations impact OS in anti-EGFR but not anti-VEGF treated mCRC - an analysis of the KRAS registry of the AGMT (Arbeitsgemeinschaft Medikamentöse Tumortherapie)

• Open Access
• Research article

Florian Huemer, Josef Thaler, Gudrun Piringer, Hubert Hackl, Lisa Pleyer, Clemens Hufnagl, Lukas Weiss, Richard Greil

Analysis of microarrays of miR-34a and its identification of prospective target gene signature in hepatocellular carcinoma

• Open Access
• Research article

Fang-Hui Ren, Hong Yang, Rong-quan He, Jing-ning Lu, Xing-gu Lin, Hai-Wei Liang, Yi-Wu Dang, Zhen-Bo Feng, Gang Chen, Dian-Zhong Luo

IMMUNEPOTENT CRP induces cell cycle arrest and caspase-independent regulated cell death in HeLa cells through reactive oxygen species production

• Open Access
• Research article

Ana Carolina Martínez-Torres, Alejandra Reyes-Ruiz, Milena Benítez-Londoño, Moises Armides Franco-Molina, Cristina Rodríguez-Padilla

Availability of anticancer medicines in public and private sectors, and their affordability by low, middle and high-income class patients in Pakistan

• Open Access
• Research article

Muhammad Rehan Sarwar, Sadia Iftikhar, Anum Saqib

Adjuvant stereotactic fractionated radiotherapy to the resection cavity in recurrent glioblastoma – the GlioCave study (NOA 17 – ARO 2016/3 – DKTK ROG trial)

• Open Access
• Study protocol

Christoph Straube, Hagen Scherb, Jens Gempt, Jan Kirschke, Claus Zimmer, Friederike Schmidt-Graf, Bernhard Meyer, Stephanie E. Combs

Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinomas harbouring BRCA1 and BRCA2 aberrations

• Open Access
• Research article

Robert L. Hollis, Alison M. Meynert, Michael Churchman, Tzyvia Rye, Melanie Mackean, Fiona Nussey, Mark J. Arends, Andrew H. Sims, Colin A. Semple, C. Simon Herrington, Charlie Gourley

Preoperative serum immunoglobulin G and A antibodies to Porphyromonas gingivalis are potential serum biomarkers for the diagnosis and prognosis of esophageal squamous cell carcinoma

• Open Access
• Research article

She-Gan Gao, Jun-Qiang Yang, Zhi-Kun Ma, Xiang Yuan, Chen Zhao, Guang-Chao Wang, Hua Wei, Xiao-Shan Feng, Yi-Jun Qi

The Brainfit study: efficacy of cognitive training and exergaming in pediatric cancer survivors – a randomized controlled trial

• Open Access
• Study protocol

Valentin Benzing, Noëmi Eggenberger, Janine Spitzhüttl, Valerie Siegwart, Manuela Pastore-Wapp, Claus Kiefer, Nedelina Slavova, Michael Grotzer, Theda Heinks, Mirko Schmidt, Achim Conzelmann, Maja Steinlin, Regula Everts, Kurt Leibundgut

Development of the body image self-rating questionnaire for breast cancer (BISQ-BC) for Chinese mainland patients

• Open Access
• Research article

Kaina Zhou, Xiaole He, Lanting Huo, Jinghua An, Minjie Li, Wen Wang, Xiaomei Li

Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

• Open Access
• Research article

Ildar V. Gainetdinov, Yulia V. Skvortsova, Sofia A. Kondratieva, Alexey Klimov, Alexey A. Tryakin, Tatyana L. Azhikina

Testicular self examination among Bahir Dar University students: application of integrated behavioral model

• Open Access
• Research article

Hordofa Gutema, Yamrot Debela, Bizuayehu Walle, Kidist Reba, Habtamu Wondiye

The exploration of contrasting pathways in Triple Negative Breast Cancer (TNBC)

• Open Access
• Research article

Shavira Narrandes, Shujun Huang, Leigh Murphy, Wayne Xu

Coordinated expression and genetic polymorphisms in Grainyhead-like genes in human non-melanoma skin cancers

• Open Access
• Research article

Agnieszka Kikulska, Tobias Rausch, Ewa Krzywinska, Magdalena Pawlak, Bartek Wilczynski, Vladimir Benes, Piotr Rutkowski, Tomasz Wilanowski

Nine primary malignant neoplasms-involving the esophagus, stomach, colon, rectum, prostate, and external ear canal-without microsatellite instability: a case report

• Open Access
• Case report

Keiichi Arakawa, Keisuke Hata, Yoko Yamamoto, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Hiroaki Nozawa, Masafumi Yoshida, Hiroshi Fukuhara, Mitsuhiro Fujishiro, Teppei Morikawa, Tatsuya Yamasoba, Kazuhiko Koike, Masashi Fukayama, Toshiaki Watanabe

Incidence, socioeconomic deprivation, volume-outcome and survival in adult patients with acute lymphoblastic leukaemia in England

• Open Access
• Research article

Ravi Maheswaran, Nick Morley

A quantitative multimodal metabolomic assay for colorectal cancer

• Open Access
• Research article

Farshad Farshidfar, Karen A. Kopciuk, Robert Hilsden, S. Elizabeth McGregor, Vera C. Mazurak, W. Donald Buie, Anthony MacLean, Hans J. Vogel, Oliver F. Bathe

PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells

• Open Access
• Research article

Ting-ting Qu, Fei Chen, Jing Wang, Yan-jun Zhang, Mo-bin Cheng, Wen-zheng Sun, Yu-fei Shen, Ye Zhang

Optimising the chick chorioallantoic membrane xenograft model of neuroblastoma for drug delivery

• Open Access
• Research article

Rasha Swadi, Grace Mather, Barry L. Pizer, Paul D. Losty, Violaine See, Diana Moss

Using Resistin, glucose, age and BMI to predict the presence of breast cancer

• Open Access
• Research article

Miguel Patrício, José Pereira, Joana Crisóstomo, Paulo Matafome, Manuel Gomes, Raquel Seiça, Francisco Caramelo

Inhibition of neddylation facilitates cell migration through enhanced phosphorylation of caveolin-1 in PC3 and U373MG cells

• Open Access
• Research article

Sung Yeon Park, Jong-Wan Park, Gun-Woo Lee, Lan Li, Yang-Sook Chun

Evaluation of Endoglin (CD105) expression in pediatric rhabdomyosarcoma

• Open Access
• Research article

Virginia Di Paolo, Ida Russo, Renata Boldrini, Lucilla Ravà, Marco Pezzullo, Maria Chiara Benedetti, Angela Galardi, Marta Colletti, Rossella Rota, Domenico Orlando, Alessandro Crocoli, Hector Peinado, Giuseppe Maria Milano, Angela Di Giannatale

Evolutionary aspects of non-metastatic breast cancer after primary treatment in a sub-Saharan African setting: a 16-year retrospective review at the Douala general hospital, Cameroon

• Open Access
• Research article

Bibiana Ateh Nzeangung, Martin Essomba Biwole, Benjamin Momo Kadia, Ndemazie Nkafu Bechem, Christian Akem Dimala, Albert Mouelle Sone

Comparison of cancer incidence in Australian farm residents 45 years and over, compared to rural non-farm and urban residents - a data linkage study

• Open Access
• Research article

Julie Depczynski, Timothy Dobbins, Bruce Armstrong, Tony Lower

MiR-199a/b-3p inhibits gastric cancer cell proliferation via down-regulating PAK4/MEK/ERK signaling pathway

• Open Access
• Research article

Bin Zeng, Wei Shi, Gao Tan

MLH1–93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation

• Open Access
• Research article

Lochlan J. Fennell, Saara Jamieson, Diane McKeone, Tracie Corish, Megan Rohdmann, Tori Furner, Mark Bettington, Cheng Liu, Futoshi Kawamata, Catherine Bond, Jolieke Van De Pols, Barbara Leggett, Vicki Whitehall

Regulation of pancreatic stellate cell activation by Notch3

• Open Access
• Research article

Haiyan Song, Yuxiang Zhang

High BCAR1 expression is associated with early PSA recurrence in ERG negative prostate cancer

• Open Access
• Research article

Asmus Heumann, Nina Heinemann, Claudia Hube-Magg, Dagmar S. Lang, Katharina Grupp, Martina Kluth, Sarah Minner, Christina Möller-Koop, Markus Graefen, Hans Heinzer, Maria Christina Tsourlakis, Waldemar Wilczak, Corinna Wittmer, Frank Jacobsen, Hartwig Huland, Ronald Simon, Thorsten Schlomm, Guido Sauter, Stefan Steurer, Patrick Lebok, Andrea Hinsch

Attributable causes of colorectal cancer in China

• Open Access
• Research article

Meng-Jia Gu, Qiu-Chi Huang, Cheng-Zhen Bao, Ying-Jun Li, Xiao-Qin Li, Ding Ye, Zhen-Hua Ye, Kun Chen, Jian-Bing Wang

A novel lncRNA-focus expression signature for survival prediction in endometrial carcinoma

• Open Access
• Research article

Meng Zhou, Zhaoyue Zhang, Hengqiang Zhao, Siqi Bao, Jie Sun

A systematic review of clinic and community intervention to increase fecal testing for colorectal cancer in rural and low-income populations in the United States – How, what and when?

• Open Access
• Research article

Melinda M. Davis, Michele Freeman, Jackilen Shannon, Gloria D. Coronado, Kurt C. Stange, Jeanne-Marie Guise, Stephanie B. Wheeler, David I. Buckley

Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins

• Open Access
• Research article

Carrie J. Lovitt, Todd B. Shelper, Vicky M. Avery

Breast carcinoma with 21-gene recurrence score lower than 18: rate of locoregional recurrence in a large series with clinical follow-up

• Open Access
• Research article

Gulisa Turashvili, Edi Brogi, Monica Morrow, Maura Dickler, Larry Norton, Clifford Hudis, Hannah Y. Wen

Inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness

• Open Access
• Research article

Charles S. Goldsmith, Sam Moon Kim, Nirmala Karunarathna, Nichole Neuendorff, L. Gerard Toussaint, David J. Earnest, Deborah Bell-Pedersen

Incidence of bone metastases in patients with solid tumors: analysis of oncology electronic medical records in the United States

• Open Access
• Research article

Rohini K. Hernandez, Sally W. Wade, Adam Reich, Melissa Pirolli, Alexander Liede, Gary H. Lyman

A train the trainer program for healthcare professionals tasked with providing psychosocial support to breast cancer survivors

• Open Access
• Research article

Eunyoung Park, Junghee Yoon, Eun-kyung Choi, Im Ryung Kim, Danbee Kang, Se-Kyung Lee, Jeong Eon Lee, Seok Jin Nam, Jin Seok Ahn, Adriaan Visser, Juhee Cho

Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer

• Open Access
• Research article

Akhileshwar Namani, Md. Matiur Rahaman, Ming Chen, Xiuwen Tang

Mechanism of recipient cell-dependent differences in exosome uptake

• Open Access
• Research article

Sayo Horibe, Toshihito Tanahashi, Shoji Kawauchi, Yoshiki Murakami, Yoshiyuki Rikitake

Relationship between the extent of resection and the survival of patients with low-grade gliomas: a systematic review and meta-analysis

• Open Access
• Research article

Liang Xia, Chenyan Fang, Gao Chen, Caixing Sun

Stromal CD10 expression in breast cancer correlates with tumor invasion and cancer stem cell phenotype

• Open Access
• Research article

Tahani Louhichi, Hanene Saad, Myriam Ben Dhiab, Sonia Ziadi, Mounir Trimeche

A modified TNM staging system for non-metastatic colorectal cancer based on nomogram analysis of SEER database

• Open Access
• Research article

Kong Xiangxing, Li Jun, Cai Yibo, Tian Yu, Chi Shengqiang, Tong Danyang, Hu Yeting, Yang Qi, Li Jingsong, Graeme Poston, Yuan Ying, Ding Kefeng

Trastuzumab without chemotherapy in the adjuvant treatment of breast cancer: subgroup results from a large observational study

• Open Access
• Research article

Peter Dall, Thorsten Koch, Thomas Göhler, Johannes Selbach, Andreas Ammon, Jochen Eggert, Nidal Gazawi, Daniela Rezek, Arthur Wischnik, Carsten Hielscher, Nicolas Schleif, Ursula Cirrincione, Axel Hinke, Gabriele Feisel-Schwickardi

Epoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway

• Open Access
• Research article

Dhiraj Kumar, Saikat Haldar, Mahadeo Gorain, Santosh Kumar, Fayaj A. Mulani, Amit S. Yadav, Lucio Miele, Hirekodathakallu V. Thulasiram, Gopal C. Kundu

Moesin expression by tumor cells is an unfavorable prognostic biomarker for oral cancer

• Open Access
• Research article

Francisco Bárbara Abreu Barros, Agnes Assao, Natália Galvão Garcia, Suely Nonogaki, André Lopes Carvalho, Fernando Augusto Soares, Luiz Paulo Kowalski, Denise Tostes Oliveira

Health services research in patients with breast cancer (CAMISS-prospective): study protocol for an observational prospective study

• Open Access
• Study protocol

Susana García-Gutierrez, Miren Orive, Cristina Sarasqueta, Maria Jose Legarreta, Nerea Gonzalez, Maximino Redondo, Amado Rivero, Pedro Serrano-Aguilar, Xavier Castells, Jose Maria Quintana, Maria Sala, Xavier Castells, Mercè Comas, Laia Domingo, Francesc Macià, Marta Roman, Anabel Romero, María Sala, Teresa Barata, Isabel Diez de la Lastra, Mariola de la Vega, Marisa Bare, Núria Torà, Joana Ferrer, Francesc Castanyer, Carmen Carmona, Susana García, Maximina Martín, Nerea Gonzalez, Miren Orive, Maria Amparo Valverde, Alberto Saez, Inma Barredo, Manuel de Toro, Josefa Ferreiro, Jose María Quintana, Jeanette Pérez, Amado Rivero, Cristina Valcárcel, María del Carmen Padilla, Maximino Redondo, Teresa Téllez, Irene Zarcos, Cristina Churruca, Amaia Perales, Javier Recio, Irune Ruiz, Cristina Sarasqueta, Jose María Urraca, Ma Jesús Michelena, Julio Moreno, Gaizka Mallabiabarrena, Patricia Cobos, Borja Otero, Javier Gorostiaga, Itsaso Troya

A randomized controlled trial of a skills training for oncologists and a communication aid for patients to stimulate shared decision making about palliative systemic treatment (CHOICE): study protocol

• Open Access
• Study protocol

I. Henselmans, E. M. A. Smets, J. C. J. M. de Haes, M. G. W. Dijkgraaf, F. Y. de Vos, H. W. M. van Laarhoven

Clinical and pathological factors influencing survival in a large cohort of triple-negative breast cancer patients

• Open Access
• Research article

Silvana Anna Maria Urru, Silvano Gallus, Cristina Bosetti, Tiziana Moi, Ricardo Medda, Elisabetta Sollai, Alma Murgia, Francesca Sanges, Giovanna Pira, Alessandra Manca, Dolores Palmas, Matteo Floris, Anna Maria Asunis, Francesco Atzori, Ciriaco Carru, Maurizio D’Incalci, Massimo Ghiani, Vincenzo Marras, Daniela Onnis, Maria Cristina Santona, Giuseppina Sarobba, Enrichetta Valle, Luisa Canu, Sergio Cossu, Alessandro Bulfone, Paolo Cossu Rocca, Maria Rosaria De Miglio, Sandra Orrù

Study protocol of a phase II clinical trial (KSCC1501A) examining oxaliplatin + S-1 for treatment of HER2-negative advanced/recurrent gastric cancer previously untreated with chemotherapy

• Open Access
• Study protocol

Hiroshi Saeki, Yasunori Emi, Eiji Oki, Shoji Tokunaga, Yoshihiro Kakeji, Yoshito Akagi, Hideo Baba, Eishi Baba, Yoshihiko Maehara

Ethnic disparities in breast cancer survival in New Zealand: which factors contribute?

• Open Access
• Research article

Sandar Tin Tin, J. Mark Elwood, Charis Brown, Diana Sarfati, Ian Campbell, Nina Scott, Reena Ramsaroop, Sanjeewa Seneviratne, Vernon Harvey, Ross Lawrenson

Efficacy of a telephone outcall program to reduce caregiver burden among caregivers of cancer patients [PROTECT]: a randomised controlled trial

• Open Access
• Research article

Leila Heckel, Kate M. Fennell, John Reynolds, Anna Boltong, Mari Botti, Richard H. Osborne, Cathrine Mihalopoulos, Jacquie Chirgwin, Melinda Williams, Cadeyrn J. Gaskin, David M. Ashley, Patricia M. Livingston

MGAT1 is a novel transcriptional target of Wnt/β-catenin signaling pathway

• Open Access
• Research article

Izzet Akiva, Necla Birgül Iyison

Serum miR-486-5p as a diagnostic marker in cervical cancer: with investigation of potential mechanisms

• Open Access
• Research article

Chunmei Li, Xiaojiao Zheng, Wei Li, Fumao Bai, Jianxin Lyu, Qing H. Meng

The preventive effect of sensorimotor- and vibration exercises on the onset of Oxaliplatin- or vinca-alkaloid induced peripheral neuropathies - STOP

• Open Access
• Study protocol

Fiona Streckmann, Maryam Balke, Helmar C. Lehmann, Vanessa Rustler, Christina Koliamitra, Thomas Elter, Michael Hallek, Michael Leitzmann, Tilman Steinmetz, Petra Heinen, Freerk T. Baumann, Wilhelm Bloch

Staging laparoscopy for locally advanced gastric cancer in Chinese patients: a multicenter prospective registry study

• Open Access
• Study protocol

Ziyu Li, Zhemin Li, Lianhai Zhang, Qian Liu, Zhenjun Wang, Zhongtao Zhang, Gang Xiao, Wei Fu, Xin Wang, Yingjiang Ye, Jianchun Yu, Fei Li, Lin Chen, Shibin Wang, Jiafu Ji

Effects of concentrated long-chain omega-3 polyunsaturated fatty acid supplementation before radical prostatectomy on prostate cancer proliferation, inflammation, and quality of life: study protocol for a phase IIb, randomized, double-blind, placebo-controlled trial

• Open Access
• Study protocol

Marie-Hélène Guertin, Karine Robitaille, Jean-François Pelletier, Thierry Duchesne, Pierre Julien, Josée Savard, Isabelle Bairati, Vincent Fradet

Metformin, Asian ethnicity and risk of prostate cancer in type 2 diabetes: a systematic review and meta-analysis

• Open Access
• Research article

Christopher B. Chen, Maxim Eskin, Dean T. Eurich, Sumit R. Majumdar, Jeffrey A. Johnson

The quality of working life questionnaire for cancer survivors (QWLQ-CS): factorial structure, internal consistency, construct validity and reproducibility

• Open Access
• Research article

Merel de Jong, Sietske J. Tamminga, Robert J. J. van Es, Monique H. W. Frings-Dresen, Angela G. E. M. de Boer

RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation

• Open Access
• Research article

Nan Wu, Dong Ren, Su Li, Wenli Ma, Shaoyan Hu, Yan Jin, Sheng Xiao

CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension

• Open Access
• Research article

Ricardo Celestino, Torfinn Nome, Ana Pestana, Andreas M. Hoff, A. Pedro Gonçalves, Luísa Pereira, Bruno Cavadas, Catarina Eloy, Trine Bjøro, Manuel Sobrinho-Simões, Rolf I. Skotheim, Paula Soares

An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation

• Open Access
• Research article

Jeffrey J. Heard, Ivy Phung, Mark I. Potes, Fuyuhiko Tamanoi

Correction to: Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer

• Open Access
• Correction

Xiao Wang, Jian Chen, Jingtao Wang, Fudong Yu, Senlin Zhao, Yu Zhang, Huamei Tang, Zhihai Peng

Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis

• Open Access
• Research article

Eileen Shaw, Megan S. Farris, Chelsea R. Stone, Jeroen W. G. Derksen, Rhys Johnson, Robert J. Hilsden, Christine M. Friedenreich, Darren R. Brenner

Adjuvant treatment of resectable biliary tract cancer with cisplatin plus gemcitabine: A prospective single center phase II study

• Open Access
• Research article

Alexander R. Siebenhüner, Heike Seifert, Helga Bachmann, Burkhardt Seifert, Thomas Winder, Jonas Feilchenfeldt, Stefan Breitenstein, Pierre-Alain Clavien, Roger Stupp, Alexander Knuth, Bernhard Pestalozzi, Panagiotis Samaras

Effect of total number of harvested lymph nodes on survival outcomes after curative resection for gastric adenocarcinoma: findings from an eastern high-volume gastric cancer center

• Open Access
• Research article

Shiela S. Macalindong, Kwang Hee Kim, Byung-Ho Nam, Keun Won Ryu, Norihito Kubo, Ja Yeon Kim, Bang Wool Eom, Hong Man Yoon, Myeong-Cherl Kook, Il Ju Choi, Young Woo Kim

MicroRNA-200a confers chemoresistance by antagonizing TP53INP1 and YAP1 in human breast cancer

• Open Access
• Research article

San-Jian Yu, Liu Yang, Qi Hong, Xia-Ying Kuang, Gen-Hong Di, Zhi-Ming Shao

Prospective longitudinal quality of life and survival outcomes in patients with advanced infiltrative hepatocellular carcinoma and portal vein thrombosis treated with Yttrium-90 radioembolization

• Open Access
• Research article

Minzhi Xing, Nima Kokabi, Juan C. Camacho, Hyun S. Kim

Obesity and breast cancer outcomes in chemotherapy patients in New Zealand – a population-based cohort study

• Open Access
• Research article

J. Mark Elwood, Sandar Tin Tin, Marion Kuper-Hommel, Ross Lawrenson, Ian Campbell

Monitoring the responsiveness of T and antigen presenting cell compartments in breast cancer patients is useful to predict clinical tumor response to neoadjuvant chemotherapy

• Open Access
• Research article

David A. Bernal-Estévez, Oscar García, Ramiro Sánchez, Carlos A. Parra-López

Colorectal cancer liver metastases – a population-based study on incidence, management and survival

• Open Access
• Research article

Jennie Engstrand, Henrik Nilsson, Cecilia Strömberg, Eduard Jonas, Jacob Freedman

Treatment selection of early stage non-small cell lung cancer: the role of the patient in clinical decision making

• Open Access
• Research article

S. Mokhles, J. J. M. E. Nuyttens, M. de Mol, J. G. J. V. Aerts, A. P. W. M. Maat, Ö. Birim, A. J. J. C. Bogers, J. J. M. Takkenberg

Correction to: A systematic comparison of copy number alterations in four types of female cancer

• Open Access
• Correction

Fatemeh Kaveh, Lars O. Baumbusch, Daniel Nebdal, Anne-Lise Børresen-Dale, Ole Christian Lingjærde, Hege Edvardsen, Vessela N. Kristensen, Hiroko K. Solvang

Additional dexamethasone in chemotherapies with carboplatin and paclitaxel could reduce the impaired glycometabolism in rat models

• Open Access
• Research article

Yanxiu Guo, Haoxia Zeng, Xiaohong Chang, Chaohua Wang, Heng Cui

Diagnostic accuracy and prediction increment of markers of epithelial-mesenchymal transition to assess cancer cell detachment from primary tumors

• Open Access
• Technical advance

Evan L. Busch, Prabhani Kuruppumullage Don, Haitao Chu, David B. Richardson, Temitope O. Keku, David A. Eberhard, Christy L. Avery, Robert S. Sandler

Variants of cancer susceptibility genes in Korean BRCA1/2 mutation-negative patients with high risk for hereditary breast cancer

• Open Access
• Research article

Ji Soo Park, Seung-Tae Lee, Eun Ji Nam, Jung Woo Han, Jung-Yun Lee, Jieun Kim, Tae Il Kim, Hyung Seok Park

Cost-effectiveness of prostate cancer screening: a systematic review of decision-analytical models

• Open Access
• Research article

Sabina Sanghera, Joanna Coast, Richard M. Martin, Jenny L. Donovan, Syed Mohiuddin

Somatic evolutionary timings of driver mutations

• Open Access
• Research article

Karen Gomez, Sayaka Miura, Louise A. Huuki, Brianna S. Spell, Jeffrey P. Townsend, Sudhir Kumar

What is it about a cancer diagnosis that would worry people? A population-based survey of adults in England

• Open Access
• Research article

Philippa J. Murphy, Laura A. V. Marlow, Jo Waller, Charlotte Vrinten

Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer

• Open Access
• Research article

Timothy O’Donnell, Elizabeth L. Christie, Arun Ahuja, Jacqueline Buros, B. Arman Aksoy, David D. L. Bowtell, Alexandra Snyder, Jeff Hammerbacher

Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma

• Open Access
• Research article

Guang-hua Xu, Ning Lou, Hang-chuan Shi, Yu-chen Xu, Hai-long Ruan, Wen Xiao, Lei Liu, Xiang Li, Hai-bing Xiao, Bin Qiu, Lin Bao, Chang-fei Yuan, Ya-li Zhou, Wen-jun Hu, Ke Chen, Hong-mei Yang, Xiao-ping Zhang

AZGP1 inhibits soft tissue sarcoma cells invasion and migration

• Open Access
• Research article

Jiayong Liu, Haibo Han, Zhengfu Fan, Marc El Beaino, Zhiwei Fang, Shu Li, Jiafu Ji

FAM3B/PANDER inhibits cell death and increases prostate tumor growth by modulating the expression of Bcl-2 and Bcl-XL cell survival genes

• Open Access
• Research article

Paula Maciel-Silva, Izabela Caldeira, Icaro de Assis Santos, Ana Claudia Oliveira Carreira, Flavia Ramos Siqueira, Eliane Antonioli, Anna Carla Goldberg, José Ernesto Belizário, Humberto Miguel Garay-Malpartida

Breast magnetic resonance imaging for surveillance of women with a personal history of breast cancer: outcomes stratified by interval between definitive surgery and surveillance MR imaging

• Open Access
• Research article

Vivian Youngjean Park, Eun-Kyung Kim, Min Jung Kim, Hee Jung Moon, Jung Hyun Yoon

A remarkable response to pazopanib, despite recurrent liver toxicity, in a patient with a high grade endometrial stromal sarcoma, a case report

• Open Access
• Sarkome in der Gynäkologie
• Case report

Arie J. Verschoor, Fabiënne A. R. M. Warmerdam, Tjalling Bosse, Judith V. M. G. Bovée, Hans Gelderblom

Assessment of cancers’ diagnostic stage in a Deaf community - survey about 4363 Deaf patients recorded in French units

• Open Access
• Research article

Vladimir Druel, Hélène Hayet, Laetitia Esman, Marie Clavel, Marie-Eve Rougé Bugat

Testes-specific protease 50 (TSP50) promotes invasion and metastasis by inducing EMT in gastric cancer

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Qing-Hua Cao, Fang Liu, Chang-Zhao Li, Ni Liu, Man Shu, Yuan Lin, Li Ding, Ling Xue

Neuromyelitis optica spectrum disorder secondary to treatment with anti-PD-1 antibody nivolumab: the first report

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• Case report

Yoshitsugu Narumi, Ryohei Yoshida, Yoshinori Minami, Yasushi Yamamoto, Shiori Takeguchi, Kohei Kano, Kae Takahashi, Tsukasa Saito, Jun Sawada, Hiroya Terui, Takayuki Katayama, Takaaki Sasaki, Yoshinobu Ohsaki

Shifting breast cancer surveillance from current hospital setting to a community based setting: a cost-effectiveness study

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Kelly M. de Ligt, Annemieke Witteveen, Sabine Siesling, Lotte M. G. Steuten

Efficacy of T-DM1 for leptomeningeal and brain metastases in a HER2 positive metastatic breast cancer patient: new directions for systemic therapy - a case report and literature review

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• Case report

Giuseppina Rosaria Rita Ricciardi, Alessandro Russo, Tindara Franchina, Silvia Schifano, Giampiero Mastroeni, Anna Santacaterina, Vincenzo Adamo

The PANDA study: a randomized phase II study of first-line FOLFOX plus panitumumab versus 5FU plus panitumumab in RAS and BRAF wild-type elderly metastatic colorectal cancer patients

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• Study protocol

Francesca Battaglin, Marta Schirripa, Federica Buggin, Filippo Pietrantonio, Federica Morano, Giorgia Boscolo, Giuseppe Tonini, Eufemia Stefania Lutrino, Jessica Lucchetti, Lisa Salvatore, Alessandro Passardi, Chiara Cremolini, Ermenegildo Arnoldi, Mario Scartozzi, Nicoletta Pella, Luca Boni, Francesca Bergamo, Vittorina Zagonel, Fotios Loupakis, Sara Lonardi

Leptin-induced ER-α-positive breast cancer cell viability and migration is mediated by suppressing CCN5-signaling via activating JAK/AKT/STAT-pathway

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Inamul Haque, Arnab Ghosh, Seth Acup, Snigdha Banerjee, Kakali Dhar, Amitabha Ray, Sandipto Sarkar, Suman Kambhampati, Sushanta K. Banerjee

Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma

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Timothy Budden, Andre van der Westhuizen, Nikola A. Bowden

Intra-arterial ethanol embolization augments response to TACE for treatment of HCC with portal venous tumor thrombus

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Biao Yang, Chun-Lin Li, Wen-hao Guo, Tian-qiang Qin, He Jiao, Ze-jun Fei, Xuan Zhou, Lin-jia Duan, Zheng-yin Liao

Variations of circulating cardiac biomarkers during and after anthracycline-containing chemotherapy in breast cancer patients

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Pierre Frères, Nassim Bouznad, Laurence Servais, Claire Josse, Stéphane Wenric, Aurélie Poncin, Jérôme Thiry, Marie Moonen, Cécile Oury, Patrizio Lancellotti, Vincent Bours, Guy Jerusalem

An advanced glioma cell invasion assay based on organotypic brain slice cultures

• Open Access
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Tanja Eisemann, Barbara Costa, Jens Strelau, Michel Mittelbronn, Peter Angel, Heike Peterziel

Vertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps

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Evelyn Hsieh, Qin Wang, Renzhi Zhang, Xin Niu, Weibo Xia, Liana Fraenkel, Karl L. Insogna, Jing Li, Jennifer S. Smith, Chunwu Zhou, You-lin Qiao, Pin Zhang

Galectin-1 is a poor prognostic factor in patients with glioblastoma multiforme after radiotherapy

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Shang-Yu Chou, Shao-Lun Yen, Chao-Cheng Huang, Eng-Yen Huang

Clinical management and outcome of patients with advanced NSCLC carrying EGFR mutations in Spain

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Edurne Arriola, Ramón García Gómez, Pilar Diz, Margarita Majem, Maite Martínez Aguillo, Javier Valdivia, Alfredo Paredes, José Miguel Sánchez-Torres, Sergio Peralta Muñoz, Isidoro Barneto, Vanesa Gutierrez, Jesús Manuel Andrade Santiago, Francisco Aparisi, Dolores Isla, Santiago Ponce, David Vicente Baz, Angel Artal, Mariluz Amador, Mariano Provencio

Genetic variation of the gene coding for microRNA-204 (miR-204) is a risk factor in acute myeloid leukaemia

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Aleksandra Butrym, Piotr Łacina, Kazimierz Kuliczkowski, Katarzyna Bogunia-Kubik, Grzegorz Mazur

Venous invasion as a risk factor for recurrence after gastrectomy followed by chemotherapy for stage III gastric cancer

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Keiji Nishibeppu, Shuhei Komatsu, Daisuke Ichikawa, Taisuke Imamura, Toshiyuki Kosuga, Kazuma Okamoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Eigo Otsuji

Evolution of quality of life in patients with breast cancer during the first year of follow-up in Morocco

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B. M. Traore, S. El Fakir, H. Charaka, N. Benaicha, A. Najdi, A. Zidouh, M. Bennani, H. Errihani, N. Mellass, A. Benider, R. Bekkali, C. Nejjari

Correction to: Impact of new generation hormone-therapy on cognitive function in elderly patients treated for a metastatic prostate cancer: Cog-Pro trial protocol

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• Correction

Marie Lange, Heidi Laviec, Hélène Castel, Natacha Heutte, Alexandra Leconte, Isabelle Léger, Bénédicte Giffard, Aurélie Capel, Martine Dubois, Bénédicte Clarisse, Elodie Coquan, Frédéric Di Fiore, Sophie Gouérant, Philippe Bartélémy, Laure Pierard, Karim Fizazi, Florence Joly

Correction to: Cancer associated fibroblasts (CAFs) are activated in cutaneous basal cell carcinoma and in the peritumoural skin

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• Correction

Silje Haukali Omland, Erika Elgstrand Wettergren, Sarah Mollerup, Maria Asplund, Tobias Mourier, Anders Johannes Hansen, Robert Gniadecki

Prevalence of high-risk HPV genotypes, categorised by their quadrivalent and nine-valent HPV vaccination coverage, and the genotype association with high-grade lesions

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María Paz-Zulueta, Ledicia Álvarez-Paredes, Juan Carlos Rodríguez Díaz, Paula Parás-Bravo, Ma. Encarnación Andrada Becerra, José María Rodríguez Ingelmo, María Montserrat Ruiz García, Joaquín Portilla, Miguel Santibañez

Variant isoforms of CD44 involves acquisition of chemoresistance to cisplatin and has potential as a novel indicator for identifying a cisplatin-resistant population in urothelial cancer

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Masayuki Hagiwara, Eiji Kikuchi, Nobuyuki Tanaka, Takeo Kosaka, Shuji Mikami, Hideyuki Saya, Mototsugu Oya

Pretreatment quality of life as a predictor of survival for patients with nasopharyngeal carcinoma treated with IMRT

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Shan-Shan Guo, Wen Hu, Qiu-Yan Chen, Jian-Mei Li, Shi-Heng Zhu, Yan He, Jia-Wen Li, Le Xia, Lu Ji, Cui-Ying Lin, Li-Ting Liu, Lin-Quan Tang, Ling Guo, Hao-Yuan Mo, Chong Zhao, Xiang Guo, Ka-Jia Cao, Chao-Nan Qian, Mu-Sheng Zeng, Ming-Huang Hong, Jian-Yong Shao, Ying Sun, Jun Ma, Yu-Ying Fan, Hai-Qiang Mai

A statewide investigation of geographic lung cancer incidence patterns and radon exposure in a low-smoking population

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Judy Y. Ou, Brynn Fowler, Qian Ding, Anne C. Kirchhoff, Lisa Pappas, Kenneth Boucher, Wallace Akerley, Yelena Wu, Kimberly Kaphingst, Garrett Harding, Deanna Kepka

An elevated expression of serum exosomal microRNA-191, − 21, −451a of pancreatic neoplasm is considered to be efficient diagnostic marker

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Takuma Goto, Mikihiro Fujiya, Hiroaki Konishi, Junpei Sasajima, Shugo Fujibayashi, Akihiro Hayashi, Tatsuya Utsumi, Hiroki Sato, Takuya Iwama, Masami Ijiri, Aki Sakatani, Kazuyuki Tanaka, Yoshiki Nomura, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Yusuke Mizukami, Yutaka Kohgo, Toshikatsu Okumura

Screening for immune-potentiating antigens from hepatocellular carcinoma patients after radiofrequency ablation by serum proteomic analysis

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Shunli Shen, Hong Peng, Ye Wang, Ming Xu, Manxia Lin, Xiaoyan Xie, Baogang Peng, Ming Kuang

Effect of neoadjuvant chemotherapy in patients with gastric cancer: a PRISMA-compliant systematic review and meta-analysis

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Zhi-Feng Miao, Xing-Yu Liu, Zhen-Ning Wang, Ting-Ting Zhao, Ying-Ying Xu, Yong-Xi Song, Jin-Yu Huang, Hao Xu, Hui-Mian Xu

Longitudinal autoantibody responses against tumor-associated antigens decrease in breast cancer patients according to treatment modality

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Rick L. Evans, James V. Pottala, Satoshi Nagata, Kristi A. Egland

A retrospective study of the safety and efficacy of paclitaxel plus ramucirumab in patients with advanced or recurrent gastric cancer with ascites

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Hiroshi Matsumoto, Akihito Kawazoe, Kaoru Shimada, Shota Fukuoka, Yasutoshi Kuboki, Hideaki Bando, Takashi Kojima, Atsushi Ohtsu, Takayuki Yoshino, Toshihiko Doi, Kohei Shitara

Selective oestrogen receptor antagonists inhibit oesophageal cancer cell proliferation in vitro

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Waleed Al-Khyatt, Cristina Tufarelli, Raheela Khan, Syed Yousef Iftikhar

Phase I clinical study of brentuximab vedotin (SGN-35) involving children with recurrent or refractory CD30-positive Hodgkin’s lymphoma or systemic anaplastic large cell lymphoma: rationale, design and methods of BV-HLALCL study: study protocol

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• Study protocol

Masahiro Sekimizu, Akihiro Iguchi, Tetsuya Mori, Yuhki Koga, Akiko Kada, Akiko M. Saito, Keizo Horibe

Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (Th1, Th2) to immune-mediated tumour cell death induced by NAC

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Viriya Kaewkangsadan, Chandan Verma, Jennifer M. Eremin, Gerard Cowley, Mohammad Ilyas, Oleg Eremin

Screening for distress in patients with primary brain tumor using distress thermometer: a systematic review and meta-analysis

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Fangkun Liu, Jing Huang, Liyang Zhang, Fan Fan, Jindong Chen, Kun Xia, Zhixiong Liu

A simple filter model to guide the allocation of healthcare resources for improving the treatment of depression among cancer patients

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Robert W. Sanson-Fisher, Natasha E. Noble, Andrew M. Searles, Simon Deeming, Rochelle E. Smits, Christopher J. Oldmeadow, Jamie Bryant

Trend analysis of the quality indicators for the Brazilian cervical cancer screening programme by region and state from 2006 to 2013

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Ricardo Filipe Alves Costa, Adhemar Longatto-Filho, Fabiana de Lima Vazquez, Céline Pinheiro, Luiz Carlos Zeferino, José Humberto Tavares Guerreiro Fregnani

Nc886 is epigenetically repressed in prostate cancer and acts as a tumor suppressor through the inhibition of cell growth

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Rafael Sebastián Fort, Cecilia Mathó, Murilo Vieira Geraldo, María Carolina Ottati, Alex Shimura Yamashita, Kelly Cristina Saito, Katia Ramos Moreira Leite, Manuel Méndez, Noemí Maedo, Laura Méndez, Beatriz Garat, Edna Teruko Kimura, José Roberto Sotelo-Silveira, María Ana Duhagon

Elevated systemic levels of the matrix metalloproteinase inhibitor TIMP-1 correlate with clinical markers of cachexia in patients with chronic pancreatitis and pancreatic cancer

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Olga Prokopchuk, Barbara Grünwald, Ulrich Nitsche, Carsten Jäger, Oleksii L. Prokopchuk, Elaine C. Schubert, Helmut Friess, Marc E. Martignoni, Achim Krüger

Analysis of tumour-infiltrating lymphocytes reveals two new biologically different subgroups of breast ductal carcinoma in situ

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Marie Beguinot, Marie-Melanie Dauplat, Fabrice Kwiatkowski, Guillaume Lebouedec, Lucie Tixier, Christophe Pomel, Frederique Penault-Llorca, Nina Radosevic-Robin

Performance of a prognostic 31-gene expression profile in an independent cohort of 523 cutaneous melanoma patients

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Jonathan S. Zager, Brian R. Gastman, Sancy Leachman, Rene C. Gonzalez, Martin D. Fleming, Laura K. Ferris, Jonhan Ho, Alexander R. Miller, Robert W. Cook, Kyle R. Covington, Kristen Meldi-Plasseraud, Brooke Middlebrook, Lewis H. Kaminester, Anthony Greisinger, Sarah I. Estrada, David M. Pariser, Lee D. Cranmer, Jane L. Messina, John T. Vetto, Jeffrey D. Wayne, Keith A. Delman, David H. Lawson, Pedram Gerami

Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil

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Manuel B. Braga-Neto, Jessica Gomes Carneiro, Alzira M. de Castro Barbosa, Igor S. Silva, Danielle C. Maia, Felipe S. Maciel, Rafael Jorge Alves de Alcântara, Paulo Roberto L. Vasconscelos, Lucia L. B. C. Braga

Randomised controlled trial protocol (GRIP study): examining the effect of involvement of a general practitioner and home care oncology nurse after a cancer diagnosis on patient reported outcomes and healthcare utilization

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• Study protocol

I. A. A. Perfors, C. W. Helsper, E. A. Noteboom, E. van der Wall, N. J. de Wit, A. M. May

A web tool for designing and conducting phase I trials using the continual reassessment method

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Nolan A. Wages, Gina R. Petroni

Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review

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• Case report

Vincenzo Dario Mandato, Federica Torricelli, Valentina Mastrofilippo, Riccardo Valli, Lorenzo Aguzzoli, Giovanni Battista La Sala

Treatment decisions, clinical outcomes, and pharmacoeconomics in the treatment of patients with EGFR mutated stage III/IV NSCLC in Germany: an observational study

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Wolfgang Schuette, Peter Schirmacher, Wilfried E. E. Eberhardt, Manfred Dietel, Ute Zirrgiebel, Lars Muehlenhoff, Michael Thomas

Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer

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Peter J. Klauck, Stacey M. Bagby, Anna Capasso, Erica L. Bradshaw-Pierce, Heather M. Selby, Anna Spreafico, John J. Tentler, Aik Choon Tan, Jihye Kim, John J. Arcaroli, Alicia Purkey, Wells A. Messersmith, Keisuke Kuida, S. Gail Eckhardt, Todd M. Pitts

Pre-operative and intra-operative detection of axillary lymph node metastases in 108 patients with invasive lobular breast cancer undergoing mastectomy

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Jerica Novak, Nikola Besic, Radan Dzodic, Barbara Gazic, Andrej Vogrin

Changes in CT morphology can be an independent response marker for patients receiving regorafenib for colorectal liver metastases: retrospective pilot study

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Yukinori Ozaki, Junichi Shindoh, Wataru Gonoi, Yujiro Nishioka, Chihiro Kondoh, Yuko Tanabe, Shuichiro Matoba, Hiroya Kuroyanagi, Masaji Hashimoto, Toshimi Takano

The FREGAT biobank: a clinico-biological database dedicated to esophageal and gastric cancers

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Christophe Mariette, Florence Renaud, Guillaume Piessen, Patrick Gele, Marie-Christine Copin, Emmanuelle Leteurtre, Christine Delaeter, Malek Dib, Stéphanie Clisant, Valentin Harter, Franck Bonnetain, Alain Duhamel, Véronique Christophe, Antoine Adenis, Olivier Glehen, Nicolas Carrere, Jacques Jougon, Denis Collet, François Paye, Denis Pezet, Bernard Meunier, Frédéric Di Fiore, Xavier Benoît D’journo, Olivier Bouché, Marie-Pierre Galais, Gil Lebreton, Nicolas Regenet, Frédéric Borie, Diane Goere, Jean-Michel Fabre, Emmanuelle Samalin, Jean Marc Sabate, Christophe Penna, Marc Pocard, Jack Porcheron, Olivier Tiffet, Cécile Brigand, Jean-Marc Regimbeau, Muriel Mathonnet, Pierre-Yves Brichon, Simon Msika, Adeline Germain, Thierry Conroy, Côme Lepage, Philippe Maingon, Jean-Philippe Metges, Medhi Ouaissi, Anne Berger, Frédérique Peschaud, Eric François, Jérôme Mouroux, Bertrand Dousset, Jean Marc Gornet, Brice Paquette, Jean-Christophe Vaillant, Janick Selves, Alexandra Traverse-Glehen, Genevieve Belleannée, Jean-François Fléjou, Pierre Dechelotte, Bruno Turlin, Christèle Moulin, Dominique Figarella-Branger, Doriane Barets, Marie-Danièle Diebold, Frederic Bibeau, Cécile Blanc Fournier, Jean-François Mosnier, Pascal Roger, Jean-Yves Scoazec, Patrick Bruneval, Valerie Rigau, Antoine Martin, Catherine Guettier, Rachid Kaci, Michel Péoc’h, Marie-Pierre Chenard, Henri Sevestre, François Labrousse, Marie-Hélène Laverriere, Maggy Grossin, Jacqueline Champigneulle, Agnès Leroux, Alain Bonnin, Marie-Cécile Nicot, Jean-François Emile, Natacha Chereau, Paul Hofman, Jean-François Michiels, Serge Guyétant, Benoît Terris, Philippe Bertheau, Severine Valmary-Degano, Blandine Massemin, Wacrenier Agnès, Crinquette Marie

CK1α overexpression correlates with poor survival in colorectal cancer

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Julia Richter, Anna-Laura Kretz, Johannes Lemke, Michael Fauler, Jens-Uwe Werner, Stephan Paschke, Frank Leithäuser, Doris Henne-Bruns, Andreas Hillenbrand, Uwe Knippschild

Whole blood microRNAs as potential biomarkers in post-operative early breast cancer patients

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Marianna Alunni-Fabbroni, Leonie Majunke, Elisabeth K. Trapp, Marie Tzschaschel, Sven Mahner, Peter A. Fasching, Tanja Fehm, Andreas Schneeweiss, Thomas Beck, Ralf Lorenz, Thomas W. P. Friedl, Wolfgang Janni, Brigitte Rack

Neoadjuvant chemoradiotherapy plus surgery versus active surveillance for oesophageal cancer: a stepped-wedge cluster randomised trial

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Bo Jan Noordman, Bas P. L. Wijnhoven, Sjoerd M. Lagarde, Jurjen J. Boonstra, Peter Paul L. O. Coene, Jan Willem T. Dekker, Michael Doukas, Ate van der Gaast, Joos Heisterkamp, Ewout A. Kouwenhoven, Grard A. P. Nieuwenhuijzen, Jean-Pierre E. N. Pierie, Camiel Rosman, Johanna W. van Sandick, Maurice J. C. van der Sangen, Meindert N. Sosef, Manon C. W. Spaander, Roelf Valkema, Edwin S. van der Zaag, Ewout W. Steyerberg, J. Jan B. van Lanschot, B. J. Noordman, J. J. B. van Lanschot, S. M. Lagarde, B. P. L. Wijnhoven, K. Biermann, A. van der Gaast, E. Ista, N. C. Krak, J. J. M. E. Nuyttens, S. Polinder, M. C. W. Spaander, E. W. Steyerberg, R. Valkema, A. Agool, J. van Baarlen, E. M. Hendriksen, R. Hoekstra, E. A. Kouwenhoven, A. van der Linde, A. Bartels-Rutten, J. van Dieren, J. van Sandick, P. Snaebjornsson, E. Vegt, F. E. M. Voncken, H. Doornewaard, G. W. Erkelens, G. S. Madretsma, E. S. van der Zaag, M. R. J. ten Broek, R. J. Dallinga, J. W. T. Dekker, V. O. Dezentjé, R. R. de Krijger, K. J. Neelis, R. Quispel, G. J. Creemers, G. A. P. Nieuwenhuijzen, M. C. van der Sangen, E. J. Schoon, D. N. J. Wyndaele, J. Buijsen, R. G. Riedl, W. M. J. Schreurs, M. N. Sosef, L. E. Oostenbrug, F. A. R. M. Warmerdam, J. J. Boonstra, M. Slingerland, W. O. de Steur, I. M. Lips, W. E. Fiets, K. van der Linde, J. Nieken, V. Oppedijk, J. P. E. N. Pierie, R. Wolf, P. P. L. O. Coene, I. Al Butaihi, M. Kliffen, E. M. M. Kuiper, E. F. Courrech Staal, M. J. R. Janssen, M. H. Liedenbaum, C. van der Post, S. A. Radema, C. Rosman, H. Rütten, P. D. Siersema, L. V. Beerepoot, W. L. Hazen, J. Heisterkamp, J. C. van Oord, T. Rozema, I. A. C. Vermeltfoort, A. A. M. van der Wurff

HtrA1 as a promising tissue marker in cancer: a meta-analysis

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Emma Altobelli, Paolo Matteo Angeletti, Manrico Morroni, Valerio Filippo Profeta

The potential predictive value of DEK expression for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer

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J. Martinez-Useros, I. Moreno, M. J. Fernandez-Aceñero, M. Rodriguez-Remirez, A. Borrero-Palacios, A. Cebrian, T. Gomez del Pulgar, L. del Puerto-Nevado, W. Li, A. Puime-Otin, N. Perez, M. S. Soengas, J. Garcia-Foncillas

Autoimmune comorbidities in patients with metastatic melanoma: a retrospective analysis of us claims data

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Qiufei Ma, Mark Shilkrut, Zhongyun Zhao, Minming Li, Nicolas Batty, Beth Barber

It is no longer the time to disregard thyroid metastases from breast cancer: a case report and review of the literature

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• Mammakarzinom
• Case report

Matilde Pensabene, Brigida Stanzione, Ivana Cerillo, Giuseppe Ciancia, Immacolata Cozzolino, Raffaella Ruocco, Caterina Condello, Giuseppe Di Lorenzo, Mario Giuliano, Valeria Forestieri, Grazia Arpino, Sabino De Placido, Rossella Lauria

A three-lncRNA signature predicts overall survival and disease-free survival in patients with esophageal squamous cell carcinoma

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Guo-Wei Huang, Yu-Jie Xue, Zhi-Yong Wu, Xiu-E Xu, Jian-Yi Wu, Hui-Hui Cao, Ying Zhu, Jian-Zhong He, Chun-Quan Li, En-Min Li, Li-Yan Xu

Frequency of the acquired resistant mutation T790 M in non-small cell lung cancer patients with active exon 19Del and exon 21 L858R: a systematic review and meta-analysis

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Zan-Feng Wang, Sheng-Xiang Ren, Wei Li, Guang-Hui Gao

Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells

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Chunwan Lu, Dafeng Yang, Maria E. Sabbatini, Aaron H. Colby, Mark W. Grinstaff, Nicholas H. Oberlies, Cedric Pearce, Kebin Liu

Arsenic trioxide attenuates STAT-3 activity and epithelial-mesenchymal transition through induction of SHP-1 in gastric cancer cells

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Sung Ho Kim, Hyo Soon Yoo, Moon Kyung Joo, Taehyun Kim, Jong-Jae Park, Beom Jae Lee, Hoon Jai Chun, Sang Woo Lee, Young-Tae Bak

Impact of body mass index on surgical outcomes of gastric cancer

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Fan Feng, Gaozan Zheng, Xiaohua Guo, Zhen Liu, Guanghui Xu, Fei Wang, Qiao Wang, Man Guo, Xiao Lian, Hongwei Zhang

Germline BRCA1/BRCA2 mutations among high risk breast cancer patients in Jordan

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Hikmat Abdel-Razeq, Amal Al-Omari, Farah Zahran, Banu Arun

The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1)

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Marthe-Susanna Wegner, Lisa Gruber, Peter Mattjus, Gerd Geisslinger, Sabine Grösch

Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?

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Suhas Vasaikar, Giorgos Tsipras, Natalia Landázuri, Helena Costa, Vanessa Wilhelmi, Patrick Scicluna, Huanhuan L. Cui, Abdul-Aleem Mohammad, Belghis Davoudi, Mingmei Shang, Sharan Ananthaseshan, Klas Strååt, Giuseppe Stragliotto, Afsar Rahbar, Kum Thong Wong, Jesper Tegner, Koon-Chu Yaiw, Cecilia Söderberg-Naucler

Association of rs2282679 A>C polymorphism in vitamin D binding protein gene with colorectal cancer risk and survival: effect modification by dietary vitamin D intake

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Yun Zhu, Peizhong Peter Wang, Guangju Zhai, Bharati Bapat, Sevtap Savas, Jennifer R. Woodrow, Peter T. Campbell, Yuming Li, Ning Yang, Xin Zhou, Elizabeth Dicks, John R. Mclaughlin, Patrick S. Parfrey

PD-L1 expression in malignant salivary gland tumors

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Koji Harada, Tarannum Ferdous, Yoshiya Ueyama

Diethylnitrosamine induces lung adenocarcinoma in FVB/N mouse

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Zsolt Mervai, Krisztina Egedi, Ilona Kovalszky, Kornélia Baghy

Prognostic implications of polycomb proteins ezh2, suz12, and eed1 and histone modification by H3K27me3 in sarcoma

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Yong Jin Cho, Soo Hee Kim, Eun Kyung Kim, Jung Woo Han, Kyoo-Ho Shin, Hyuk Hu, Kyung Sik Kim, Young Deuk Choi, Sunghoon Kim, Young Han Lee, Jin-Suck Suh, Joong Bae Ahn, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha, Sung-Taek Jung, Hyo Song Kim

The effect of propofol and sevoflurane on cancer cell, natural killer cell, and cytotoxic T lymphocyte function in patients undergoing breast cancer surgery: an in vitro analysis

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Jeong-Ae Lim, Chung-Sik Oh, Tae-Gyoon Yoon, Ji Yeon Lee, Seung-Hyun Lee, Young-Bum Yoo, Jung-Hyun Yang, Seong-Hyop Kim

Smoking and prostate cancer: a life course analysis

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Evelyn Jiménez-Mendoza, Ruth A. Vázquez-Salas, Tonatiuh Barrientos-Gutierrez, Luz Myriam Reynales-Shigematsu, Isaac Roberto Labra-Salgado, Hugo A. Manzanilla-García, Luisa E. Torres-Sánchez

Trends in molecular subtypes of breast cancer: description of incidence rates between 2007 and 2012 from three French registries

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Marion Cortet, Aurélie Bertaut, Florence Molinié, Simona Bara, Françoise Beltjens, Charles Coutant, Patrick Arveux

Factors predicting patient satisfaction in women with advanced breast cancer: a prospective study

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Wendy W. T. Lam, Ava Kwong, Dacita Suen, Janice Tsang, Inda Soong, Tze Kok Yau, Winnie Yeo, Joyce Suen, Wing Ming Ho, Ka Yan Wong, Wing Kin Sze, Alice W. Y. Ng, Richard Fielding

Incidence and histological patterns of thyroid cancer in Sri Lanka 2001-2010: an analysis of national cancer registry data

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Umesh Jayarajah, Ashan Fernando, Saumyakala Prabashani, Eshani A. Fernando, Sanjeewa A. Seneviratne

Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells

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Carlos M. Galmarini, Maud Martin, Benjamin Pierre Bouchet, María José Guillen-Navarro, Marta Martínez-Diez, Juan Fernando Martinez-Leal, Anna Akhmanova, Pablo Aviles

Is RNASEL:p.Glu265* a modifier of early-onset breast cancer risk for carriers of high-risk mutations?

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Tú Nguyen-Dumont, Zhi L. Teo, Fleur Hammet, Alexis Roberge, Maryam Mahmoodi, Helen Tsimiklis, Daniel J. Park, Bernard J. Pope, Andrew Lonie, Miroslav K. Kapuscinski, Khalid Mahmood, David E. Goldgar, Graham G. Giles, Ingrid Winship, John L. Hopper, Melissa C. Southey

Assessing the performance of a Loop Mediated Isothermal Amplification (LAMP) assay for the detection and subtyping of high-risk suptypes of Human Papilloma Virus (HPV) for Oropharyngeal Squamous Cell Carcinoma (OPSCC) without DNA purification

• Open Access
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Mitchell G. Rohatensky, Devon M. Livingstone, Paul Mintchev, Heather K. Barnes, Steven C. Nakoneshny, Douglas J. Demetrick, Joseph C. Dort, Guido van Marle

Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM

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Lina Mörén, Richard Perryman, Tim Crook, Julia K. Langer, Kevin Oneill, Nelofer Syed, Henrik Antti

Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro

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Ozlem Aslan, Mattia Cremona, Clare Morgan, Lydia W. Cheung, Gordon B. Mills, Bryan T. Hennessy

Characteristics of people living in Italy after a cancer diagnosis in 2010 and projections to 2020

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Stefano Guzzinati, Saverio Virdone, Roberta De Angelis, Chiara Panato, Carlotta Buzzoni, Riccardo Capocaccia, Silvia Francisci, Anna Gigli, Manuel Zorzi, Giovanna Tagliabue, Diego Serraino, Fabio Falcini, Claudia Casella, Antonio Giampiero Russo, Fabrizio Stracci, Bianca Caruso, Maria Michiara, Anna Luisa Caiazzo, Marine Castaing, Stefano Ferretti, Lucia Mangone, Giuseppa Rudisi, Flavio Sensi, Guido Mazzoleni, Fabio Pannozzo, Rosario Tumino, Mario Fusco, Paolo Ricci, Gemma Gola, Adriano Giacomin, Francesco Tisano, Giuseppa Candela, Anna Clara Fanetti, Filomena Pala, Antonella Sutera Sardo, Massimo Rugge, Laura Botta, Luigino Dal Maso

Prevalence of Mouse Mammary Tumor Virus (MMTV)-like sequences in human breast cancer tissues and adjacent normal breast tissues in Saudi Arabia

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Reem Al Dossary, Khaled R. Alkharsah, Haitham Kussaibi

Factors associated with breast cancer recurrences or mortality and dynamic prediction of death using history of cancer recurrences: the French E3N cohort

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Alexandre Lafourcade, Mathilde His, Laura Baglietto, Marie-Christine Boutron-Ruault, Laure Dossus, Virginie Rondeau

Comparison of first-line chemotherapy regimens for ovarian carcinosarcoma: a single institution case series and review of the literature

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Melissa Brackmann, Marina Stasenko, Shitanshu Uppal, Jake Erba, R. Kevin Reynolds, Karen McLean

Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case report

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• Case report

Min-joo Ahn, Kanghan Lee, Kyung Hwa Lee, Jin Woong Kim, In-Young Kim, Woo Kyun Bae

Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)

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Una Kjällquist, Rikard Erlandsson, Nicholas P. Tobin, Amjad Alkodsi, Ikram Ullah, Gustav Stålhammar, Eva Karlsson, Thomas Hatschek, Johan Hartman, Sten Linnarsson, Jonas Bergh

NBS1 rs2735383 polymorphism is associated with an increased risk of laryngeal carcinoma

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Xinmei Hu, Juan Liao, Huiliu Zhao, Feng Chen, Xuefeng Zhu, Jiangheng Li, Qingqing Nong

Prognostic impact of presumed breast or ovarian cancer among patients with unfavorable-subset cancer of unknown primary site

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Makoto Kodaira, Kan Yonemori, Tatsunori Shimoi, Akihiko Yoshida, Masayuki Yoshida, Atsuko Kitano, Akihiko Shimomura, Mayu Yunokawa, Chikako Shimizu, Yuichi Takiguchi, Yasuhiro Fujiwara, Kenji Tamura

High-dose thiotepa-related neurotoxicity and the role of tramadol in children

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Christophe Maritaz, Francois Lemare, Agnes Laplanche, Sylvie Demirdjian, Dominique Valteau-Couanet, Christelle Dufour

Real-life feasibility of home-based pulmonary rehabilitation in chemotherapy-treated patients with thoracic cancers: a pilot study

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Cecile Olivier, Jean-Marie Grosbois, Alexis B. Cortot, Sophie Peres, Christophe Heron, Julie Delourme, Marianne Gierczynski, Anne Hoorelbeke, Arnaud Scherpereel, Olivier Le Rouzic

Male BRCA mutation carriers: clinical characteristics and cancer spectrum

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Mohammed Ibrahim, Siddhartha Yadav, Foluso Ogunleye, Dana Zakalik

Genetic determinants of sporadic breast cancer in Sri Lankan women

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Nirmala Dushyanthi Sirisena, Adebowale Adeyemo, Anchala I. Kuruppu, Nilaksha Neththikumara, Nilakshi Samaranayake, Vajira H. W. Dissanayake

Serum and blood based biomarkers for lung cancer screening: a systematic review

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Gavin C. W. Chu, Kim Lazare, Frank Sullivan

A novel miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry contributes to leukemogenesis in acute myeloid leukemia

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Laixi Bi, Bin Zhou, Haiying Li, Licai He, Chunjing Wang, Zhonggai Wang, Liqing Zhu, Mengqian Chen, Shenmeng Gao

HIPECT4: multicentre, randomized clinical trial to evaluate safety and efficacy of Hyperthermic intra-peritoneal chemotherapy (HIPEC) with Mitomycin C used during surgery for treatment of locally advanced colorectal carcinoma

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• Study protocol

A. Arjona-Sánchez, P. Barrios, E. Boldo-Roda, B. Camps, J. Carrasco-Campos, V. Concepción Martín, A. García-Fadrique, A. Gutiérrez-Calvo, R. Morales, G. Ortega-Pérez, E. Pérez-Viejo, A. Prada-Villaverde, J. Torres-Melero, E. Vicente, P. Villarejo-Campos, J. M. Sánchez-Hidalgo, A. Casado-Adam, Ruben García-Martin, Manuel Medina, T. Caro, C. Villar, Enrique Aranda, M. T. Cano-Osuna, C. Díaz-López, E. Torres-Tordera, F. J. Briceño-Delgado, S. Rufián-Peña

Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study

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Masanori Nojima, Motoki Iwasaki, Yoshio Kasuga, Shiro Yokoyama, Hiroshi Onuma, Hideki Nishimura, Ritsu Kusama, Teruhiko Yoshida, Shoichiro Tsugane

Impact of PKCε downregulation on autophagy in glioblastoma cells

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Ewa Toton, Aleksandra Romaniuk, Natalia Konieczna, Johann Hofmann, Jan Barciszewski, Maria Rybczynska

Treatment using oxaliplatin and S-1 adjuvant chemotherapy for pathological stage III gastric cancer: a multicenter phase II study (TOSA trial) protocol

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• Study protocol

Tsutomu Namikawa, Hiromichi Maeda, Hiroyuki Kitagawa, Koji Oba, Akihito Tsuji, Takaki Yoshikawa, Michiya Kobayashi, Kazuhiro Hanazaki

Phase I study of an active immunotherapy for asymptomatic phase Lymphoplasmacytic lymphoma with DNA vaccines encoding antigen-chemokine fusion: study protocol

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• Study protocol

Sheeba K. Thomas, Soung-chul Cha, D. Lynne Smith, Kun Hwa Kim, Sapna R. Parshottam, Sheetal Rao, Michael Popescu, Vincent Y. Lee, Sattva S. Neelapu, Larry W. Kwak

Transarterial chemoembolization (TACE) using mitomycin and lipiodol with or without degradable starch microspheres for hepatocellular carcinoma: comparative study

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Tatjana Gruber-Rouh, Cornelia Schmitt, Nagy N. N. Naguib, N. A. Nour-Eldin, Katrin Eichler, Martin Beeres, Thomas J. Vogl

Physical activity and risk of testicular cancer: a systematic review

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Stephanie Huang, Virginia Signal, Diana Sarfati, Caroline Shaw, James Stanley, Katherine McGlynn, Jason Gurney

Lack of association between cigarette smoking and Epstein Barr virus reactivation in the nasopharynx in people with elevated EBV IgA antibody titres

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Yufeng Chen, Yifei Xu, Weilin Zhao, Xue Xiao, Xiaoying Zhou, Longde Lin, Tingting Huang, Jian Liao, Yancheng Li, Xiaoyun Zeng, Guangwu Huang, Weimin Ye, Zhe Zhang

The T790M resistance mutation in EGFR is only found in cfDNA from erlotinib-treated NSCLC patients that harbored an activating EGFR mutation before treatment

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Christina Demuth, Anne Tranberg Madsen, Britta Weber, Lin Wu, Peter Meldgaard, Boe Sandahl Sorensen

Fertility preservation healthcare circuit and networks in cancer patients worldwide: what are the issues?

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Kathleen Melan, Frederic Amant, Jacqueline Veronique-Baudin, Clarisse Joachim, Eustase Janky

In vitro and in silico validation of CA3 and FHL1 downregulation in oral cancer

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Cláudia Maria Pereira, Ana Carolina de Carvalho, Felipe Rodrigues da Silva, Matias Eliseo Melendez, Roberta Cardim Lessa, Valéria Cristina C. Andrade, Luiz Paulo Kowalski, André L. Vettore, André Lopes Carvalho

Safety and efficacy of temsirolimus as second line treatment for patients with recurrent bladder cancer

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Marina Pulido, Guilhem Roubaud, Anne-Laure Cazeau, Hakim Mahammedi, Lionel Vedrine, Florence Joly, Loic Mourey, Christian Pfister, Alejandro Goberna, Barbara Lortal, Carine Bellera, Philippe Pourquier, Nadine Houédé

RECORD-4 multicenter phase 2 trial of second-line everolimus in patients with metastatic renal cell carcinoma: Asian versus non-Asian population subanalysis

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Lin Yang, Anna Alyasova, Dingwei Ye, Antonia Ridolfi, Luca Dezzani, Robert J. Motzer

Treatment of upper tract urothelial carcinoma with ureteroscopy and thulium laser: a retrospective single center study

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Jin Wen, Zhi G. Ji, Han Z. Li

Radiotherapy related skin toxicity (RAREST-01): Mepitel® film versus standard care in patients with locally advanced head-and-neck cancer

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Carlos Narvaez, Claudia Doemer, Christian Idel, Cornelia Setter, Denise Olbrich, Zaza Ujmajuridze, Jesper Hansen Carl, Dirk Rades

Oxidative damage and response to Bacillus Calmette-Guérin in bladder cancer cells expressing sialyltransferase ST3GAL1

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Paulo F. Severino, Mariana Silva, Mylene Carrascal, Nadia Malagolini, Mariella Chiricolo, Giulia Venturi, Roberto Barbaro Forleo, Annalisa Astolfi, Mariangela Catera, Paula A. Videira, Fabio Dall’Olio

A prospective study to investigate the role of serial serum mesothelin in monitoring mesothelioma

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Duneesha de Fonseka, David T. Arnold, Louise Stadon, Anna Morley, Emma Keenan, Michael Darby, Lynne Armstrong, Paul Virgo, Nick A. Maskell

MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression

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Zhikun Liu, Jie Li, Jun Chen, Qiaonan Shan, Haojiang Dai, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng

Association of differential miRNA expression with hepatic vs. peritoneal metastatic spread in colorectal cancer

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Sabine Heublein, Markus Albertsmeier, David Pfeifer, Lisa Loehrs, Alexandr V. Bazhin, Thomas Kirchner, Jens Werner, Jens Neumann, Martin Kurt Angele

Metastatic cardiac tumors: from clinical presentation through diagnosis to treatment

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Ivana Burazor, Sarit Aviel-Ronen, Massimo Imazio, Orly Goitein, Marina Perelman, Natalia Shelestovich, Ninoslav Radovanovic, Vladimir Kanjuh, Iris Barshack, Yehuda Adler

Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options

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Peter F. McAnena, Andrew McGuire, A. Ramli, C. Curran, C. Malone, R. McLaughlin, K. Barry, James A.L. Brown, M. J. Kerin

Filtration based assessment of CTCs and CellSearch® based assessment are both powerful predictors of prognosis for metastatic breast cancer patients

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Hanna Huebner, Peter A. Fasching, Walter Gumbrecht, Sebastian Jud, Claudia Rauh, Mark Matzas, Peter Paulicka, Katja Friedrich, Michael P. Lux, Bernhard Volz, Paul Gass, Lothar Häberle, Franziska Meier-Stiegen, Andreas Hartkopf, Hans Neubauer, Katrin Almstedt, Matthias W. Beckmann, Tanja N. Fehm, Matthias Ruebner

Glucose, lipids and gamma-glutamyl transferase measured before prostate cancer diagnosis and secondly diagnosed primary tumours: a prospective study in the Swedish AMORIS cohort

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Cecilia Bosco, Hans Garmo, Niklas Hammar, Göran Walldius, Ingmar Jungner, Håkan Malmström, Lars Holmberg, Mieke Van Hemelrijck

Rapid symptomatic relief of HER2-positive gastric cancer leptomeningeal carcinomatosis with lapatinib, trastuzumab and capecitabine: a case report

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• Case report

Xiao-Dong Jiao, Chunming Ding, Yuan-Sheng Zang, Guanzhen Yu

Glycolysis is essential for chemoresistance induced by transient receptor potential channel C5 in colorectal cancer

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Teng Wang, Kuan Ning, Xu Sun, Chun Zhang, Lin-fang Jin, Dong Hua

Determinants of cancer screening awareness and participation among Indonesian women

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Sumadi L. Anwar, Gindo Tampubolon, Mieke Van Hemelrijck, Susanna H. Hutajulu, Johnathan Watkins, Wahyu Wulaningsih

Evaluating different breast tumor progression models using screening data

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Åsbjørn Schumacher Westvik, Harald Weedon-Fekjær, Jan Mæhlen, Knut Liestøl

Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy

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Antoni Domagala, Joanna Stachura, Magdalena Gabrysiak, Angelika Muchowicz, Radoslaw Zagozdzon, Jakub Golab, Malgorzata Firczuk

Preliminary qualification of a novel, hypoxic-based radiologic signature for trans-arterial chemoembolization in hepatocellular carcinoma

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David J. Pinato, Madhava Pai, Isabella Reccia, Markand Patel, Alexandros Giakoustidis, Georgios Karamanakos, Azelea Rushd, Shiraz Jamshaid, Alberto Oldani, Glenda Grossi, Mario Pirisi, Paul Tait, Rohini Sharma

Successful treatment with pazopanib plus PD-1 inhibitor and RAK cells for advanced primary hepatic angiosarcoma: a case report

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• Case report

Yu Qiao, Jihong Yang, Lili Liu, Yixin Zeng, Jie Ma, Jing Jia, Li Zhang, Xiaoguang Li, Peihong Wu, Wenchao Wang, Dongge Liu, Huan Chen, Yunbo Zhao, Huan Xi, Yao Wang

Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients

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Marek Kowalczyk, Marcin Orłowski, Piotr Siermontowski, Dariusz Mucha, Krzysztof Zinkiewicz, Waldemar Kurpiewski, Ewa Zieliński, Iwona Kowalczyk, Agnieszka Pedrycz

Real life patterns of care and progression free survival in metastatic renal cell carcinoma patients: retrospective analysis of cross-sectional data

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Rana Maroun, Laura Mitrofan, Laure Benjamin, Gaelle Nachbaur, Franck Maunoury, Philippe Le Jeunne, Isabelle Durand-Zaleski

Structural and advanced imaging in predicting MGMT promoter methylation of primary glioblastoma: a region of interest based analysis

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Yu Han, Lin-Feng Yan, Xi-Bin Wang, Ying-Zhi Sun, Xin Zhang, Zhi-Cheng Liu, Hai-Yan Nan, Yu-Chuan Hu, Yang Yang, Jin Zhang, Ying Yu, Qian Sun, Qiang Tian, Bo Hu, Gang Xiao, Wen Wang, Guang-Bin Cui

A novel combined systemic inflammation-based score can predict survival of intermediate-to-advanced hepatocellular carcinoma patients undergoing transarterial chemoembolization

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Chang Liu, Lei Li, Wu-sheng Lu, Hua Du, Lu-nan Yan, Tian-fu Wen, Wu-ran Wei, Li Jiang, Ming-qing Xu

The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells

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Eleanor M. O’Brien, Joanna L. Selfe, Ana Sofia Martins, Zoë S. Walters, Janet M. Shipley

A randomised trial to compare cognitive outcome after gamma knife radiosurgery versus whole brain radiation therapy in patients with multiple brain metastases: research protocol CAR-study B

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• Study protocol

Wietske C. M. Schimmel, Eline Verhaak, Patrick E. J. Hanssens, Karin Gehring, Margriet M. Sitskoorn

LGR5 overexpression confers poor relapse-free survival in breast cancer patients

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Ming-Feng Hou, Po-Ming Chen, Pei-Yi Chu

Body mass index and lung cancer risk: a pooled analysis based on nested case-control studies from four cohort studies

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Harinakshi Sanikini, Jian-Min Yuan, Lesley M. Butler, Woon-Puay Koh, Yu-Tang Gao, Annika Steffen, Mattias Johansson, Paolo Vineis, Gary E. Goodman, Matt J. Barnett, Rayjean J. Hung, Chu Chen, Isabelle Stücker

Gap junctions contribute to anchorage-independent clustering of breast cancer cells

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Fabien Gava, Lise Rigal, Odile Mondesert, Elise Pesce, Bernard Ducommun, Valérie Lobjois

Microenvironment dependent gene expression signatures in reprogrammed human colon normal and cancer cell lines

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Egle Strainiene, Mindaugas Binkis, Silvija Urnikyte, Vaidotas Stankevicius, Ausra Sasnauskiene, Gabrielis Kundrotas, Andrius Kazlauskas, Kestutis Suziedelis

High-level cytoplasmic claudin 3 expression is an independent predictor of poor survival in triple-negative breast cancer

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Anniina Jääskeläinen, Ylermi Soini, Arja Jukkola-Vuorinen, Päivi Auvinen, Kirsi-Maria Haapasaari, Peeter Karihtala

The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors

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Heleen K. Bronsveld, Marie L. De Bruin, Jelle Wesseling, Joyce Sanders, Ingrid Hofland, Vibeke Jensen, Marloes T. Bazelier, Bas ter Braak, Anthonius de Boer, Peter Vestergaard, Marjanka K. Schmidt

Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy

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Kim A. Brogden, Deepak Parashar, Andrea R. Hallier, Terry Braun, Fang Qian, Naiyer A. Rizvi, Aaron D. Bossler, Mohammed M. Milhem, Timothy A. Chan, Taher Abbasi, Shireen Vali

Centralising specialist cancer surgery services in England: survey of factors that matter to patients and carers and health professionals

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Mariya Melnychuk, Cecilia Vindrola-Padros, Michael Aitchison, Caroline S. Clarke, Naomi J. Fulop, Claire Levermore, Satish B. Maddineni, Caroline M. Moore, Muntzer M. Mughal, Catherine Perry, Kathy Pritchard-Jones, Angus I. G. Ramsay, David Shackley, Jonathan Vickers, Stephen Morris

Positive expression of Midkine predicts early recurrence and poor prognosis of initially resectable combined hepatocellular cholangiocarcinoma

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Ming-Chun Ma, Yi-Ju Chen, Tai-Jan Chiu, Jui Lan, Chien-Ting Liu, Yi-Ching Chen, Hsin-Ho Tien, Yen-Yang Chen

Low-dose aspirin use and survival in colorectal cancer: results from a population-based cohort study

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Ronan T. Gray, Helen G. Coleman, Carmel Hughes, Liam J. Murray, Chris R. Cardwell

Development and evaluation of a risk assessment tool to improve clinical triage accuracy for colonoscopic investigations

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Anton R. Lord, Lisa A. Simms, Allison Brown, Katherine Hanigan, Krupa Krishnaprasad, Belinda Schouten, Anthony R. Croft, Mark N. Appleyard, Graham L. Radford-Smith

Stellate cells and mesenchymal stem cells in benign mammary stroma are associated with risk factors for breast cancer – an observational study

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Björn Logi Isfoss, Bo Holmqvist, Elin Sand, Johan Forsell, Helena Jernström, Håkan Olsson

Compound A attenuates toll-like receptor 4-mediated paclitaxel resistance in breast cancer and melanoma through suppression of IL-8

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Rochanawan Sootichote, Peti Thuwajit, Ekapot Singsuksawat, Malee Warnnissorn, Pa-thai Yenchitsomanus, Suthinee Ithimakin, Jomjit Chantharasamee, Chanitra Thuwajit

Correction to: Palliative external beam radiotherapy for the treatment of tumor bleeding in inoperable advanced gastric cancer

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• Correction

Yun Hee Lee, Jeong Won Lee, Hong Seok Jang

Dairy products and colorectal cancer in middle eastern and north African countries: a systematic review

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K. El kinany, M. Deoula, Z. Hatime, B. Bennani, K. El Rhazi

Impact of timing of adjuvant chemotherapy on survival in stage III colon cancer: a population-based study

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Peng Gao, Xuan-zhang Huang, Yong-xi Song, Jing-xu Sun, Xiao-wan Chen, Yu Sun, Yu-meng Jiang, Zhen-ning Wang

Effect of surgery and radiotherapy on complete blood count, lymphocyte subsets and inflammatory response in patients with advanced oral cancer

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Tadej Dovšak, Alojz Ihan, Vojko Didanovič, Andrej Kansky, Miha Verdenik, Nataša Ihan Hren

Comparative oesophageal cancer risk assessment of hot beverage consumption (coffee, mate and tea): the margin of exposure of PAH vs very hot temperatures

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Alex O. Okaru, Anke Rullmann, Adriana Farah, Elvira Gonzalez de Mejia, Mariana C. Stern, Dirk W. Lachenmeier

A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies

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Marilia Takada, Maciej Parys, Emmalena Gregory-Bryson, Paulo Vilar Saavedra, Matti Kiupel, Vilma Yuzbasiyan-Gurkan

The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2

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Hamid Maadi, Babak Nami, Junfeng Tong, Gina Li, Zhixiang Wang

Clinical decision making in the era of immunotherapy for high grade-glioma: report of four cases

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• Case report

Surabhi Ranjan, Martha Quezado, Nancy Garren, Lisa Boris, Christine Siegel, Osorio Lopes Abath Neto, Brett J. Theeler, Deric M. Park, Edjah Nduom, Kareem A. Zaghloul, Mark R. Gilbert, Jing Wu

Correction to: Oncology practitioners’ perspectives and practice patterns of post-treatment cancer survivorship care in the Asia-Pacific region: results from the STEP study

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• Correction

Raymond Javan Chan, Patsy Yates, Qiuping Li, Hiroko Komatsu, Violeta Lopez, Myat Thandar, Selva Titus Chacko, Winnie Kwok Wei So, Kanaungnit Pongthavornkamol, Myungsun Yi, Pongpak Pittayapan, Jesson Butcon, David Wyld, Alex Molassiotis

Phase II study of bevacizumab, cisplatin, and docetaxel plus maintenance bevacizumab as first-line treatment for patients with advanced non-squamous non-small-cell lung cancer combined with exploratory analysis of circulating endothelial cells: Thoracic Oncology Research Group (TORG)1016

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Satoshi Ikeda, Terufumi Kato, Takashi Ogura, Akimasa Sekine, Tsuneyuki Oda, Noriyuki Masuda, Satoshi Igawa, Ken Katono, Sakiko Otani, Kouzo Yamada, Haruhiro Saito, Tetsuro Kondo, Yukio Hosomi, Yoshiro Nakahara, Masanori Nishikawa, Keiko Utumi, Yuki Misumi, Takeharu Yamanaka, Kentaro Sakamaki, Hiroaki Okamoto

Patients’ experiences of diagnosis and management of papillary thyroid microcarcinoma: a qualitative study

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Brooke Nickel, Juan P. Brito, Ray Moynihan, Alexandra Barratt, Susan Jordan, Kirsten McCaffery

High CD8+ and absence of Foxp3+ T lymphocytes infiltration in gallbladder tumors correlate with prolonged patients survival

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Paula Fluxá, Daniel Rojas-Sepúlveda, María Alejandra Gleisner, Andrés Tittarelli, Pablo Villegas, Loreto Tapia, María Teresa Rivera, Mercedes Natalia López, Felipe Catán, Mario Uribe, Flavio Salazar-Onfray

Feasibility, useability and acceptability of technology-based interventions for informal cancer carers: a systematic review

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Natalie Heynsbergh, Leila Heckel, Mari Botti, Patricia M. Livingston

New paste for severe stomatitis in patients undergoing head-and-neck cancer radiotherapy and/or chemotherapy with oral appliance

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Ayumi Sakuramoto, Yoko Hasegawa, Kazuma Sugahara, Yoshiyuki Komoda, Kana Hasegawa, Shinichi Hikasa, Mai Kurashita, Junya Sakai, Masahiro Arita, Kazuhiro Yasukawa, Hiromitsu Kishimoto

Systematic reviews and cancer research: a suggested stepwise approach

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• Review

George A. Kelley, Kristi S. Kelley

Safety assessment of sorafenib in Chinese patients with unresectable hepatocellular carcinoma: subgroup analysis of the GIDEON study

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Sheng-Long Ye, Jiamei Yang, Ping Bie, Shuijun Zhang, Xiaoping Chen, Fengyong Liu, Luming Liu, Jie Zhou, Kefeng Dou, Chunyi Hao, Guoliang Shao, Qiang Xia, Yajin Chen, Jijin Yang, Xiaxing Deng, Yunpeng Liu, Yunfei Yuan, Zhiren Fu, Keiko Nakajima, Zhengguang Lv

Identification of novel enriched recurrent chimeric COL7A1-UCN2 in human laryngeal cancer samples using deep sequencing

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Ye Tao, Neil Gross, Xiaojiao Fan, Jianming Yang, Maikun Teng, Xu Li, Guojun Li, Yang Zhang, Zhigang Huang

AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity

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Sanja Brolih, Scott K. Parks, Valérie Vial, Jérôme Durivault, Livio Mostosi, Jacques Pouysségur, Gilles Pagès, Vincent Picco

Threat of biographical disruption: the gendered construction and experience of infertility following cancer for women and men

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Jane M. Ussher, Janette Perz, Annie Miller, Pandora Patterson, Gerard Wain, Kim Hobbs, Catherine Mason, Laura Kirsten, Edith Weisberg, Alison Butt, Joanne Cummings, Kathryn Nattress, Chloe Parton

Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma

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Hongyang Lu, Shifeng Yang, Huineng Zhu, Xiaoling Tong, Fajun Xie, Jing Qin, Na Han, Xue Wu, Yun Fan, Yang W. Shao, Weimin Mao

A phase II trial of S-1 and oxaliplatin in patients with advanced hepatocellular carcinoma

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Dae-Won Lee, Kyung-Hun Lee, Hee-Jun Kim, Tae-Yong Kim, Jin-Soo Kim, Sae-Won Han, Do-Youn Oh, Jee Hyun Kim, Seock-Ah Im, Tae-You Kim

Mixed response on regorafenib treatment for GIST (gastro-intestinal stromal tumor) according to 18F–FDG-PET/CT

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• Case report

Donatienne Van Weehaeghe, Olivier Gheysens, Vincent Vandecaveye, Patrick Schöffski, Koen Van Laere, Christophe M. Deroose

A population-based analysis of germline BRCA1 and BRCA2 testing among ovarian cancer patients in an era of histotype-specific approaches to ovarian cancer prevention

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Gillian E. Hanley, Jessica N. McAlpine, Dianne Miller, David Huntsman, Kasmintan A. Schrader, C. Blake Gilks, Gillian Mitchell

ATF-3/miR-590/GOLPH3 signaling pathway regulates proliferation of breast cancer

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Qiong Song, Qiu Chen, Qimin Wang, Longqiu Yang, Dongdong Lv, Guangli Jin, Jiaying Liu, Baolin Li, Xuejie Fei

Detection and interval cancer rates during the transition from screen-film to digital mammography in population-based screening

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Valérie D. V. Sankatsing, Jacques Fracheboud, Linda de Munck, Mireille J. M. Broeders, Nicolien T. van Ravesteyn, Eveline A. M. Heijnsdijk, André L. M. Verbeek, Johannes D. M. Otten, Ruud M. Pijnappel, Sabine Siesling, Harry J. de Koning

Case report: 8 years after liver transplantation: de novo hepatocellular carcinoma 8 months after HCV clearance through IFN-free antiviral therapy

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• Case report

Giuliano Ramadori, Patrizia Bosio, Federico Moriconi, Ihtzaz A. Malik

Temporal and geographic variation in the systemic treatment of advanced prostate cancer

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Megan E. V. Caram, Jason P. Estes, Jennifer J. Griggs, Paul Lin, Bhramar Mukherjee

Signaling protein signature predicts clinical outcome of non-small-cell lung cancer

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Bao-Feng Jin, Fan Yang, Xiao-Min Ying, Lin Gong, Shuo-Feng Hu, Qing Zhao, Yi-Da Liao, Ke-Zhong Chen, Teng Li, Yan-Hong Tai, Yuan Cao, Xiao Li, Yan Huang, Xiao-Yan Zhan, Xuan-He Qin, Jin Wu, Shuai Chen, Sai-Sai Guo, Yu-Cheng Zhang, Jing Chen, Dan-Hua Shen, Kun-Kun Sun, Lu Chen, Wei-Hua Li, Ai-Ling Li, Na Wang, Qing Xia, Jun Wang, Tao Zhou

TIPE3 differentially modulates proliferation and migration of human non-small-cell lung cancer cells via distinct subcellular location

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Guannan Wang, Chun Guo, Hui Zhao, Zhenzhen Pan, Faliang Zhu, Lining Zhang, Qun Wang

Quality assurance target for community-based breast cancer screening in China: a model simulation

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Lan Yang, Jing Wang, Juan Cheng, Yuan Wang, Wenli Lu

Burden of early, advanced and metastatic breast cancer in The Netherlands

• Open Access
• Research article

G. T. Vondeling, G. L. Menezes, E. P. Dvortsin, F. G. A. Jansman, I. R. Konings, M. J. Postma, M. H. Rozenbaum

GABAB receptor regulates proliferation in the high-grade chondrosarcoma cell line OUMS-27 via apoptotic pathways

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Kiyoto Kanbara, Yoshinori Otsuki, Masahito Watanabe, Syunichi Yokoe, Yoshiaki Mori, Michio Asahi, Masashi Neo

Exploration for novel inhibitors showing back-to-front approach against VEGFR-2 kinase domain (4AG8) employing molecular docking mechanism and molecular dynamics simulations

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Shailima Rampogu, Ayoung Baek, Amir Zeb, Keun Woo Lee

Prevalence of pathogenic BRCA1/2 germline mutations among 802 women with unilateral triple-negative breast cancer without family cancer history

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Christoph Engel, Kerstin Rhiem, Eric Hahnen, Sibylle Loibl, Karsten E. Weber, Sabine Seiler, Silke Zachariae, Jan Hauke, Barbara Wappenschmidt, Anke Waha, Britta Blümcke, Marion Kiechle, Alfons Meindl, Dieter Niederacher, Claus R. Bartram, Dorothee Speiser, Brigitte Schlegelberger, Norbert Arnold, Peter Wieacker, Elena Leinert, Andrea Gehrig, Susanne Briest, Karin Kast, Olaf Riess, Günter Emons, Bernhard H. F. Weber, Jutta Engel, Rita K. Schmutzler

Scar site metastasis of renal cell carcinoma diagnosed on-site cytology: a case report

• Open Access
• Case report

Santosh Tummidi, Pragati Sathe, Prachi Gholap, Manoj Patil, Kanchan Kothari

Comprehensive evaluation of NT5E/CD73 expression and its prognostic significance in distinct types of cancers

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Tao Jiang, Xiaofeng Xu, Meng Qiao, Xuefei Li, Chao Zhao, Fei Zhou, Guanghui Gao, Fengying Wu, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Changyun Zhai, Caicun Zhou

Correction to: Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM

• Open Access
• Correction

Lina Mörén, Richard Perryman, Tim Crook, Julia K. Langer, Kevin Oneill, Nelofer Syed, Henrik Antti

NSCLC molecular testing in Central and Eastern European countries

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Ales Ryska, Peter Berzinec, Luka Brcic, Tanja Cufer, Rafal Dziadziuszko, Maya Gottfried, Ilona Kovalszky, Włodzimierz Olszewski, Buge Oz, Lukas Plank, Jozsef Timar

Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas

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Charlotte Aaberg-Jessen, Mia D. Sørensen, Ana L. S. A. Matos, José M. Moreira, Nils Brünner, Arnon Knudsen, Bjarne W. Kristensen

Androgen deprivation therapy during and after post-prostatectomy radiotherapy in patients with prostate cancer: a case control study

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Myong Kim, Cheryn Song, In Gab Jeong, Seung-Kwon Choi, Myungchan Park, Myungsun Shim, Young Seok Kim, Dalsan You, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn

CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma

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Anke Schlüter, Patrick Weller, Oliver Kanaan, Ivonne Nel, Lukas Heusgen, Benedikt Höing, Pia Haßkamp, Sebastian Zander, Magis Mandapathil, Nina Dominas, Judith Arnolds, Boris A. Stuck, Stephan Lang, Agnes Bankfalvi, Sven Brandau

Preventing cervical cancer using HPV self-sampling: direct mailing of test-kits increases screening participation more than timely opt-in procedures - a randomized controlled trial

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Mette Tranberg, Bodil Hammer Bech, Jan Blaakær, Jørgen Skov Jensen, Hans Svanholm, Berit Andersen

MYC amplification in subtypes of breast cancers in African American women

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Tammey J. Naab, Anita Gautam, Luisel Ricks-Santi, Ashwini K. Esnakula, Yasmine M. Kanaan, Robert L. DeWitty, Girmay Asgedom, Khepher H. Makambi, Massih Abawi, Jan K. Blancato

Diagnostic and prognostic implications of ribosomal protein transcript expression patterns in human cancers

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James M. Dolezal, Arie P. Dash, Edward V. Prochownik

Time to diagnosis and associated costs of an outpatient vs inpatient setting in the diagnosis of lymphoma: a retrospective study of a large cohort of major lymphoma subtypes in Spain

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Xavier Bosch, Carmen Sanclemente-Ansó, Ona Escoda, Esther Monclús, Jonathan Franco-Vanegas, Pedro Moreno, Mar Guerra-García, Neus Guasch, Alfons López-Soto

Sepsis increases perioperative metastases in a murine model

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Lee-Hwa Tai, Abhirami A. Ananth, Rashmi Seth, Almohanad Alkayyal, Jiqing Zhang, Christiano Tanese de Souza, Phillip Staibano, Michael A. Kennedy, Rebecca C. Auer

The prognostic value of microvascular invasion in early-intermediate stage hepatocelluar carcinoma: a propensity score matching analysis

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Junyi Shen, Jun Wen, Chuan Li, Tianfu Wen, Lvnan Yan, Bo Li, Jiayin Yang, Changli Lu

Possible association between androgenic alopecia and risk of prostate cancer and testicular germ cell tumor: a systematic review and meta-analysis

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Weijun Liang, Liuying Song, Zheng Peng, Yan Zou, Shengming Dai

Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

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Trinidad Dierssen-Sotos, Camilo Palazuelos-Calderón, José-Juan Jiménez-Moleón, Nuria Aragonés, Jone M. Altzibar, Gemma Castaño-Vinyals, Vicente Martín-Sanchez, Inés Gómez-Acebo, Marcela Guevara, Adonina Tardón, Beatriz Pérez-Gómez, Pilar Amiano, Victor Moreno, Antonio J. Molina, Jéssica Alonso-Molero, Conchi Moreno-Iribas, Manolis Kogevinas, Marina Pollán, Javier Llorca

Clinical and misdiagnosed analysis of primary pulmonary lymphoma: a retrospective study

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D. Yao, L. Zhang, P. L. Wu, X. L. Gu, Y. F. Chen, L. X. Wang, X. Y. Huang

Correction to: Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options

• Open Access
• Correction

Peter F. McAnena, Andrew McGuire, A. Ramli, C. Curran, C. Malone, R. McLaughlin, K. Barry, James A. L. Brown, M. J. Kerin

The SBRT database initiative of the German Society for Radiation Oncology (DEGRO): patterns of care and outcome analysis of stereotactic body radiotherapy (SBRT) for liver oligometastases in 474 patients with 623 metastases

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N. Andratschke, H. Alheid, M. Allgäuer, G. Becker, O. Blanck, J. Boda-Heggemann, T. Brunner, M. Duma, S. Gerum, M. Guckenberger, G. Hildebrandt, R. J. Klement, V. Lewitzki, C. Ostheimer, A. Papachristofilou, C. Petersen, T. Schneider, R. Semrau, S. Wachter, D. Habermehl

Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression

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Diana David, Arun Surendran, Jissa V. Thulaseedharan, Asha S. Nair

Prognostic nutritional index as a predictor of survival in resectable gastric cancer patients with normal preoperative serum carcinoembryonic antigen levels: a propensity score matching analysis

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Noriyuki Hirahara, Yoshitsugu Tajima, Yusuke Fujii, Shunsuke Kaji, Tetsu Yamamoto, Ryoji Hyakudomi, Takahito Taniura, Yasunari Kawabata

A novel splicing site IRP1 somatic mutation in a patient with pheochromocytoma and JAK2V617F positive polycythemia vera: a case report

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• Case report

Ying Pang, Garima Gupta, Chunzhang Yang, Herui Wang, Thanh-Truc Huynh, Ziedulla Abdullaev, Svetlana D. Pack, Melanie J. Percy, Terence R. J. Lappin, Zhengping Zhuang, Karel Pacak

Integrated genomic analysis identifies clinically relevant subtypes of renal clear cell carcinoma

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Peng Wu, Jia-Li Liu, Shi-Mei Pei, Chang-Peng Wu, Kai Yang, Shu-Peng Wang, Song Wu

Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

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Yan Qiao, Tingting Yang, Yong Gan, Wenzhen Li, Chao Wang, Yanhong Gong, Zuxun Lu

Using nomogram of the Barcelona Clinic Liver Cancer system for treatment selection in patients with stage C hepatocellular carcinoma

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Chia-Yang Hsu, Po-Hong Liu, Shu-Yein Ho, Cheng-Yuan Hsia, Praneeth Kudaravalli, Yun-Hsuan Lee, Yi-You Chiou, Ya-Ju Tsai, Yi-Hsiang Huang, Teh-Ia Huo

A comparison of nephrotoxicity between patients with a solitary-functioning kidney and those with bilateral-functioning kidneys in cisplatin-based chemotherapy for advanced urothelial carcinoma: a Japanese retrospective multi-institutional study

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Takamitsu Inoue, Jun Miyazaki, Daishi Ichioka, Shintaro Narita, Susumu Kageyama, Mikio Sugimoto, Koji Mitsuzuka, Yusuke Shiraishi, Hidefumi Kinoshita, Hironobu Wakeda, Takeshi Nomoto, Eiji Kikuchi, Yoshiyuki Matsui, Keiko Fujie, Tomonori Habuchi, Hiroyuki Nishiyama

Thyroid cancer: trends in incidence, mortality and clinical-pathological patterns in Zhejiang Province, Southeast China

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Lingbin Du, Youqing Wang, Xiaohui Sun, Huizhang Li, Xinwei Geng, Minghua Ge, Yimin Zhu

Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study

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Hanaa Hardi, Rahma Melki, Zouhour Boughaleb, Tijani El Harroudi, Souria Aissaoui, Noureddine Boukhatem

The curious case of Gαs gain-of-function in neoplasia

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• Debate

Giulio Innamorati, Thomas M. Wilkie, Havish S. Kantheti, Maria Teresa Valenti, Luca Dalle Carbonare, Luca Giacomello, Marco Parenti, Davide Melisi, Claudio Bassi

Knowledge, attitudes, and practices toward cervical cancer prevention among women in Kampong Speu Province, Cambodia

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Sothy Touch, Jin-Kyoung Oh

Long-term trastuzumab (Herceptin®) treatment in a continuation study of patients with HER2-positive breast cancer or HER2-positive gastric cancer

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Volkmar Müller, Michael Clemens, Jacek Jassem, Nedal Al-Sakaff, Petra Auclair, Eveline Nüesch, Debbie Holloway, Mona Shing, Yung-Jue Bang

Dose escalation can maximize therapeutic potential of sunitinib in patients with metastatic renal cell carcinoma

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Anikó Maráz, Adrienn Cserháti, Gabriella Uhercsák, Éva Szilágyi, Zoltán Varga, János Révész, Renáta Kószó, Linda Varga, Zsuzsanna Kahán

Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial

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• Study protocol

Susen Burock, Severin Daum, Ulrich Keilholz, Konrad Neumann, Wolfgang Walther, Ulrike Stein

Health seeking behavior and its determinants for cervical cancer among women of childbearing age in Hossana Town, Hadiya zone, Southern Ethiopia: community based cross sectional study

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Yitagesu Habtu, Samuel Yohannes, Tariku Laelago

Cancer awareness among community pharmacist: a systematic review

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Kofi Boamah Mensah, Frasia Oosthuizen, Adwoa Bemah Bonsu

Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report

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• Case report

Kenji Yorita, Kazuya Tsuji, Yoko Takano, Naoto Kuroda, Kei Sakamoto, Kaoru Arii, Yukio Yoshimoto, Kimiko Nakatani, Satoshi Ito

Unusual bilateral ovarian metastases from ileal gastrointestinal stromal tumor (GIST): a case report

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• Gastrointestinale Tumoren
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Antonio De Leo, Margherita Nannini, Giulia Dondi, Donatella Santini, Milena Urbini, Elisa Gruppioni, Pierandrea De Iaco, Anna Myriam Perrone, Maria Abbondanza Pantaleo

Re-challenging immune checkpoint inhibitor in a patient with advanced non-small cell lung cancer: a case report

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• NSCLC
• Case report

Taiki Hakozaki, Yusuke Okuma, Jumpei Kashima

CircRNAs as biomarkers of cancer: a meta-analysis

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Miao Wang, Yuxi Yang, Jian Xu, Wen Bai, Xueli Ren, Huijian Wu

Myxoid liposarcoma: local relapse and metastatic pattern in 43 patients

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Hans Roland Dürr, Jessica Rauh, Andrea Baur-Melnyk, Thomas Knösel, Lars Lindner, Falk Roeder, Volkmar Jansson, Alexander Klein

Relationship between time elapsed since completion of radiotherapy and quality of life of patients with breast cancer

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Jing-Jie Zhang, Hang Shu, Shuai-Shuai Hu, Yang Yu, Yi Sun, Yin Lv

Underutilization and disparities in access to EGFR testing among Medicare patients with lung cancer from 2010 – 2013

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Julie A. Lynch, Brygida Berse, Merry Rabb, Paul Mosquin, Rob Chew, Suzanne L. West, Nicole Coomer, Daniel Becker, John Kautter

Novel biomarker-based model for the prediction of sorafenib response and overall survival in advanced hepatocellular carcinoma: a prospective cohort study

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Hwi Young Kim, Dong Hyeon Lee, Jeong-Hoon Lee, Young Youn Cho, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon

The effect of surgery on the survival status of patients with locally advanced cervical cancer after radiotherapy/chemoradiotherapy: a meta-analysis

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Dan Shi, Zhenzhen Liang, Cheng Zhang, Huaiyu Zhang, Xiaodong Liu

Impact of RUNX2 on drug-resistant human pancreatic cancer cells with p53 mutations

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Toshinori Ozaki, Meng Yu, Danjing Yin, Dan Sun, Yuyan Zhu, Youquan Bu, Meixiang Sang

The serum-based VeriStrat® test is associated with proinflammatory reactants and clinical outcome in non-small cell lung cancer patients

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Mary Jo Fidler, Cristina L. Fhied, Joanna Roder, Sanjib Basu, Selina Sayidine, Ibtihaj Fughhi, Mark Pool, Marta Batus, Philip Bonomi, Jeffrey A. Borgia

Efficacy and safety of everolimus treatment in a hemodialysis patient with metastatic atypical bronchial carcinoid: case report and literature review

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• Lungenkarzinome
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M. P. Brizzi, A. La Salvia, M. Tampellini, C. Sonetto, M. Volante, G. V. Scagliotti

From symptom discovery to treatment - women's pathways to breast cancer care: a cross-sectional study

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Jennifer Moodley, Lydia Cairncross, Thurandrie Naiker, Deborah Constant

Tumor-infiltrating mast cells predict prognosis and gemcitabine-based adjuvant chemotherapeutic benefit in biliary tract cancer patients

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Xiaobo Bo, Jie Wang, Tao Suo, Xiaoling Ni, Han Liu, Sheng Shen, Min Li, Yueqi Wang, Houbao Liu, Jiejie Xu

Effective osimertinib treatment in a patient with discordant T790 M mutation detection between liquid biopsy and tissue biopsy

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• Case report

Isa Mambetsariev, Lalit Vora, Kim Wai Yu, Ravi Salgia

Germline breast cancer susceptibility gene mutations and breast cancer outcomes

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Yong Alison Wang, Jhih-Wei Jian, Chen-Fang Hung, Hung-Pin Peng, Chi-Fan Yang, Hung-Chun Skye Cheng, An-Suei Yang

Age greater than 60 years portends a worse prognosis in patients with papillary thyroid cancer: should there be three age categories for staging?

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Rondi M. Kauffmann, J. Blair Hamner, Philip H. G. Ituarte, John H. Yim

The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

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Junya Matsushita, Kazuyuki Okamura, Kazuhiko Nakabayashi, Takehiro Suzuki, Yu Horibe, Tomoko Kawai, Toshihiro Sakurai, Satoshi Yamashita, Yoshikazu Higami, Gaku Ichihara, Kenichiro Hata, Keiko Nohara

Punch biopsies shorten time to clearance of high-risk human papillomavirus infections of the uterine cervix

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K. U. Petry, J. Horn, A. Luyten, R. T. Mikolajczyk

The characteristics of ctDNA reveal the high complexity in matching the corresponding tumor tissues

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Nong Yang, Yi Li, Zhidong Liu, Hao Qin, Duanming Du, Xinkai Cao, Xiaoqing Cao, Jun Li, Dongge Li, Bo Jiang, Lincan Duan, Haiyan Yang, Zhenghua Zhang, Hao Lin, Jianying Li, Zhenhua Yang, Lei Xiong, Hua Shen, Lizhu Lin, Fugen Li

Comparisons of tumor-infiltrating lymphocyte levels and the 21-gene recurrence score in ER-positive/HER2-negative breast cancer

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Sung Gwe Ahn, Yoon Jin Cha, Soon June Bae, Chanik Yoon, Hak Woo Lee, Joon Jeong

Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages

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Eng-Yen Huang, Jen-Chieh Chang, Hong-Hwa Chen, Chieh-Ying Hsu, Hsuan-Chih Hsu, Keng-Liang Wu

Mental disorders around cancer diagnosis and increased hospital admission rate - a nationwide cohort study of Swedish cancer patients

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Jianwei Zhu, Arvid Sjölander, Katja Fall, Unnur Valdimarsdottir, Fang Fang

Anti-EGFR targeted therapy delivered before versus during radiotherapy in locoregionally advanced nasopharyngeal carcinoma: a big-data, intelligence platform-based analysis

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Hao Peng, Ling-Long Tang, Xu Liu, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Yuan Zhang, Li-Zhi Liu, Li Tian, Ying Guo, Ying Sun, Jun Ma

Frequency of HPV in oral cavity squamous cell carcinoma

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Priscila Marinho de Abreu, Anna Clara Gregório Có, Pedro Leite Azevedo, Isabella Bittencourt do Valle, Karine Gadioli de Oliveira, Sônia Alves Gouvea, Melissa Freitas Cordeiro-Silva, Iúri Drummond Louro, José Roberto Vasconcelos de Podestá, Jeferson Lenzi, Agenor Sena, Elismauro Francisco Mendonça, Sandra Lúcia Ventorin von Zeidler

Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cells

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Elisa M. Vuorinen, Nina K. Rajala, Teemu O. Ihalainen, Anne Kallioniemi

Outcomes of Pemetrexed-based chemotherapies in HER2-mutant lung cancers

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Yan Wang, Shijia Zhang, Fengying Wu, Jing Zhao, Xuefei Li, Chao Zhao, Shengxiang Ren, Caicun Zhou

Nomograms predict long-term survival for patients with periampullary adenocarcinoma after pancreatoduodenectomy

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Chaobin He, Yize Mao, Jun Wang, Fangting Duan, Xiaojun Lin, Shengping Li

GDF15 predict platinum response during first-line chemotherapy and can act as a complementary diagnostic serum biomarker with CA125 in epithelial ovarian cancer

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Dan Zhao, Xiaobing Wang, Wei Zhang

Neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in locally advanced nasopharyngeal carcinoma

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Jiraporn Setakornnukul, Kullathorn Thephamongkhol

Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-γ-linolenic acid peroxidation dependent mechanism

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Yi Xu, Xiaoyu Yang, Tao Wang, Liu Yang, Yu-Ying He, Keith Miskimins, Steven Y. Qian

The prognostic significance of topoisomerase II alpha protein in early stage luminal breast cancer

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Xin An, Fei Xu, Rongzhen Luo, Qiufan Zheng, Jiabin Lu, Yanhua Yang, Tao Qin, Zhongyu Yuan, Yanxia Shi, Wenqi Jiang, Shusen Wang

A phase I/Ib study of OTSGC-A24 combined peptide vaccine in advanced gastric cancer

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Raghav Sundar, Sun Young Rha, Hiroki Yamaue, Masahiro Katsuda, Koji Kono, Hyo Song Kim, Chan Kim, Kousaku Mimura, Ley-Fang Kua, Wei Peng Yong

Erlotinib treatment after platinum-based therapy in elderly patients with non-small-cell lung cancer in routine clinical practice – results from the ElderTac study

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Wolfgang M. Brueckl, H. Jost Achenbach, Joachim H. Ficker, Wolfgang Schuette

Shorter survival in adolescent and young adult patients, compared to adult patients, with stage IV colorectal cancer in Japan

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Dai Shida, Yuka Ahiko, Taro Tanabe, Takefumi Yoshida, Shunsuke Tsukamoto, Hiroki Ochiai, Atsuo Takashima, Narikazu Boku, Yukihide Kanemitsu

Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models

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Susan Tsai, Laura McOlash, Katie Palen, Bryon Johnson, Christine Duris, Qiuhui Yang, Michael B. Dwinell, Bryan Hunt, Douglas B. Evans, Jill Gershan, Michael A. James

Detection of circulating tumor cells in patients with pituitary tumors

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• Case report

Gao Hua, He Yanjiao, Liu Qian, Wang Jichao, Zhang Yazhuo

To fast, or not to fast before chemotherapy, that is the question

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• Debate

Riccardo Caccialanza, Emanuele Cereda, Francesco De Lorenzo, Gabriella Farina, Paolo Pedrazzoli

Effective treatment of apatinib in desmoplastic small round cell tumor: a case report and literature review

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Chunyu Shi, Ye Feng, Lei Chao Zhang, Da Yong Ding, Ming Yu Yan, Lu Pan

Patterns of follow up and survivorship care for people with colorectal cancer in new South Wales, Australia: a population-based survey

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Jane M. Young, Ivana Durcinoska, Katie DeLoyde, Michael J. Solomon

Randomized clinical trial testing the efficacy and safety of 0.5% colchicine cream versus photodynamic therapy with methyl aminolevulinate in the treatment of skin field cancerization: study protocol

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• Study protocol

Anna Carolina Miola, Eliane Roio Ferreira, Luciana Patricia Fernandes Abbade, Juliano Vilaverde Schmitt, Helio Amante Miot

Activated innate lymphoid cell populations accumulate in human tumour tissues

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Maryam Salimi, Ruozheng Wang, Xuan Yao, Xi Li, Xiyan Wang, Yuhui Hu, Xumei Chang, Peiwen Fan, Tao Dong, Graham Ogg

Delphinidin induced protective autophagy via mTOR pathway suppression and AMPK pathway activation in HER-2 positive breast cancer cells

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Jingyao Chen, Yanfeng Zhu, Weiwei Zhang, Xiaoli Peng, Jie Zhou, Fei Li, Bin Han, Xin Liu, Yu Ou, Xiaoping Yu

Coexisting of bone marrow fibrosis, dysplasia and an X chromosomal abnormality in chronic neutrophilic leukemia with CSF3R mutation: a case report and literature review

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• Case report

Xue Bin Wu, Wei Wei Wu, Yue Zhou, Xuan Wang, Jia Li, Yang Yu

Expression of Reg IV and SOX9 and their correlation in human gastric cancer

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Na Zhang, Dandan Chai, Huifen Du, Kesheng Li, Wenguang Xie, Xingwen Li, Rong Yang, Xiaowen Lian, Yang Xu

Association between age factors and strategies for promoting participation in gastric and colorectal cancer screenings

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Chisato Hamashima, Hiroshi Sano

A national cross-sectional study of adherence to timely mammography use in Malta

• Open Access
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Danika Marmarà, Vincent Marmarà, Gill Hubbard

Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers

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Cécile Le Page, Kurosh Rahimi, Martin Köbel, Patricia N. Tonin, Liliane Meunier, Lise Portelance, Monique Bernard, Brad H. Nelson, Marcus Q. Bernardini, John M. S. Bartlett, Dimcho Bachvarov, Walter H. Gotlieb, Blake Gilks, Jessica N. McAlpine, Mark W. Nachtigal, Alain Piché, Peter H. Watson, Barbara Vanderhyden, David G. Huntsman, Diane M. Provencher, Anne-Marie Mes-Masson

Androgen receptor in advanced breast cancer: is it useful to predict the efficacy of anti-estrogen therapy?

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Giuseppe Bronte, Andrea Rocca, Sara Ravaioli, Maurizio Puccetti, Maria Maddalena Tumedei, Emanuela Scarpi, Daniele Andreis, Roberta Maltoni, Samanta Sarti, Lorenzo Cecconetto, Anna Fedeli, Elisabetta Pietri, Valeria De Simone, Silvia Asioli, Dino Amadori, Sara Bravaccini

Ezrin and E-cadherin expression profile in cervical cytology: a prognostic marker for tumor progression in cervical cancer

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Ana E. Zacapala-Gómez, Napoleón Navarro-Tito, Luz del C. Alarcón-Romero, Carlos Ortuño-Pineda, Berenice Illades-Aguiar, Eduardo Castañeda-Saucedo, Julio Ortiz-Ortiz, Olga L. Garibay-Cerdenares, Marco A. Jiménez-López, Miguel A. Mendoza-Catalán

Quality of life of survivors of malignant pleural mesothelioma in Japan: a cross sectional study

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Yasuko Nagamatsu, Isao Oze, Keisuke Aoe, Katsuyuki Hotta, Katsuya Kato, Junko Nakagawa, Keiko Hara, Takumi Kishimoto, Nobukazu Fujimoto

Impact of a behaviorally-based weight loss intervention on parameters of insulin resistance in breast cancer survivors

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Kim L. Dittus, Jean R. Harvey, Janice Y. Bunn, Nathan D. Kokinda, Karen M. Wilson, Jeff Priest, Richard E. Pratley

Cost effectiveness analysis of afatinib versus pemetrexed-cisplatin for first-line treatment of locally advanced or metastatic EGFR mutation positive non-small-cell lung cancer from the Singapore healthcare payer’s perspective

• Open Access
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Ping-Tee Tan, Mohamed Ismail Abdul Aziz, Fiona Pearce, Wan-Teck Lim, David Bin-Chia Wu, Kwong Ng

Validation of the Taiwan Chinese version of the EORTC QLQ-CR29 to assess quality of life in colorectal cancer patients

• Open Access
• Research article

Ming-Hung Shen, Ling-Ping Chen, Thien-Fiew Ho, Ying-Yih Shih, Ching-Shui Huang, Wei-Chu Chie, Chi-Cheng Huang

Neoadjuvant degarelix with or without apalutamide followed by radical prostatectomy for intermediate and high-risk prostate cancer: ARNEO, a randomized, double blind, placebo-controlled trial

• Open Access
• Study protocol

Lorenzo Tosco, Annouschka Laenen, Thomas Gevaert, Isabelle Salmon, Christine Decaestecker, Elai Davicioni, Christine Buerki, Frank Claessens, Johan Swinnen, Karolien Goffin, Raymond Oyen, Wouter Everaerts, Lisa Moris, Gert De Meerleer, Karin Haustermans, Steven Joniau

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

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Elizabeth Bowler, Sean Porazinski, Simon Uzor, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Kasper M. A. Rouschop, John Hancock, Ian Wilson, Michael Ladomery

The alterations of cytokeratin and vimentin protein expressions in primary esophageal spindle cell carcinoma

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Xin Min Li, Xin Song, Xue Ke Zhao, Shou Jia Hu, Rang Cheng, Shuang Lv, Dan Feng Du, Xiang Yang Zhang, Jian Liang Lu, Jian Wei Ku, Dong Yun Zhang, Yao Zhang, Zong Min Fan, Li Dong Wang

Significance of CD133 positive cells in four novel HPV-16 positive cervical cancer-derived cell lines and biopsies of invasive cervical cancer

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Shifa Javed, Bal Krishan Sharma, Swati Sood, Sanjeev Sharma, Rashmi Bagga, Shalmoli Bhattacharyya, Charan Singh Rayat, Lakhbir Dhaliwal, Radhika Srinivasan

The identification of H3F3A mutation in giant cell tumour of the clivus and the histological diagnostic algorithm of other clival lesions permit the differential diagnosis in this location

• Open Access
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Federica Scotto di Carlo, Giuseppina Divisato, Maurizio Iacoangeli, Teresa Esposito, Fernando Gianfrancesco

Design and rationale for the life after stopping tyrosine kinase inhibitors (LAST) study, a prospective, single-group longitudinal study in patients with chronic myeloid leukemia

• Open Access
• Study protocol

Ehab Atallah, Charles A. Schiffer, Kevin P. Weinfurt, Mei-Jie Zhang, Jerald P. Radich, Vivian G. Oehler, Javier Pinilla-Ibarz, Michael W. N. Deininger, Li Lin, Richard A. Larson, Michael J. Mauro, Joseph O. Moore, Ellen K. Ritchie, Neil P. Shah, Richard T. Silver, Martha Wadleigh, Jorge Cortes, James Thompson, Jessica Guhl, Mary M. Horowitz, Kathryn E. Flynn

The Warburg effect in human pancreatic cancer cells triggers cachexia in athymic mice carrying the cancer cells

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Feng Wang, Hongyi Liu, Lijuan Hu, Yunfei Liu, Yijie Duan, Rui Cui, Wencong Tian

Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma

• Open Access
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Chengsheng Wu, Nidhi Gupta, Yung-Hsing Huang, Hai-Feng Zhang, Abdulraheem Alshareef, Alexandra Chow, Raymond Lai

A study on volatile organic compounds emitted by in-vitro lung cancer cultured cells using gas sensor array and SPME-GCMS

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Reena Thriumani, Ammar Zakaria, Yumi Zuhanis Has-Yun Hashim, Amanina Iymia Jeffree, Khaled Mohamed Helmy, Latifah Munirah Kamarudin, Mohammad Iqbal Omar, Ali Yeon Md Shakaff, Abdul Hamid Adom, Krishna C. Persaud

Negative cancer beliefs, recognition of cancer symptoms and anticipated time to help-seeking: an international cancer benchmarking partnership (ICBP) study

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Anette Fischer Pedersen, Lindsay Forbes, Kate Brain, Line Hvidberg, Christian Nielsen Wulff, Magdalena Lagerlund, Senada Hajdarevic, Samantha L. Quaife, Peter Vedsted

Internet-based self-help smoking cessation and alcohol moderation interventions for cancer survivors: a study protocol of two RCTs

• Open Access
• Study protocol

Ajla Mujcic, Matthijs Blankers, Brigitte Boon, Rutger Engels, Margriet van Laar

Higher satisfaction with an alternative collection device for stool sampling in colorectal cancer screening with fecal immunochemical test: a cross-sectional study

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Hye Young Shin, Mina Suh, Kui Son Choi, Sang-Hyun Hwang, Jae Kwan Jun, Dong Soo Han, You Kyoung Lee, Jae Hwan Oh, Chan Wha Lee, Do-Hoon Lee

Altered monocyte differentiation and macrophage polarization patterns in patients with breast cancer

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Chih-Hsing Hung, Fang-Ming Chen, Yi-Ching Lin, Mei-Lan Tsai, Shih-Ling Wang, Yen-Chun Chen, Yi-Ting Chen, Ming-Feng Hou

Up-regulation of ceRNA TINCR by SP1 contributes to tumorigenesis in breast cancer

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Yun Liu, Yaying Du, Xiaopeng Hu, Lu Zhao, Wenfei Xia

Impact of resistance training on body composition and metabolic syndrome variables during androgen deprivation therapy for prostate cancer: a pilot randomized controlled trial

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Jacqueline K. Dawson, Tanya B. Dorff, E. Todd Schroeder, Christianne J. Lane, Mitchell E. Gross, Christina M. Dieli-Conwright

Influence of complete administration of adjuvant chemotherapy cycles on overall and disease-free survival in locally advanced rectal cancer: post hoc analysis of a randomized, multicenter, non-inferiority, phase 3 trial

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Flavius Sandra-Petrescu, Florian Herrle, Iris Burkholder, Peter Kienle, Ralf-Dieter Hofheinz

Laparoscopy-assisted colectomy as an Oncologically safe alternative for patients with stage T4 Colon Cancer: a propensity-matched cohort study

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Hao Wang, Xiaoyu Chen, Hao Liu, Tingyu Mou, Haijun Deng, Liying Zhao, Guoxin Li

A comparison of the local immune status between the primary and metastatic tumor in colorectal cancer: a retrospective study

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Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Shinichiro Kashiwagi, Hiroaki Tanaka, Kosei Hirakawa, Masaichi Ohira

Compared characteristics of current vs. past smokers at the time of diagnosis of a first-time lung or head and neck cancer: a cross-sectional study

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Corinne Vannimenus, Hélène Bricout, Olivier Le Rouzic, François Mouawad, Dominique Chevalier, Eric Dansin, Laurence Rotsaert, Gautier Lefebvre, Olivier Cottencin, Henri Porte, Arnaud Scherpereel, Asmaa El Fahsi, Florence Richard, Benjamin Rolland, Corinne Vannimenus, Françoise Weingertner, Hélène Bricout, Olivier Le Rouzic, François Mouawad, Dominique Chevalier, Eric Dansin, Stéphanie Clisant, Laurence Rotsaert, Gautier Lefebvre, Olivier Cottencin, Henri Porte, Arnaud Scherpereel, Asmaa El Fahsi, Dienabou Sylla, Florence RICHARD, Benjamin Rolland

Epstein-Barr virus positive peripheral T cell lymphoma with novel variants in STAT5B of a pediatric patient: a case report

• Open Access
• Case report

Zihang Chen, Limin Gao, Mi Wang, Yuan Tang, Sha Zhao, Weiping Liu

Role of cytarabine in paediatric acute promyelocytic leukemia treated with the combination of all-trans retinoic acid and arsenic trioxide: a randomized controlled trial

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Li Zhang, Yao Zou, Yumei Chen, Ye Guo, Wenyu Yang, Xiaojuan Chen, Shuchun Wang, Xiaoming Liu, Min Ruan, Jiayuan Zhang, Tianfeng Liu, Fang Liu, Benquan Qi, Wenbin An, Yuanyuan Ren, Lixian Chang, Xiaofan Zhu

Gynecologic cancer survivor preferences for long-term surveillance

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Matthew Schlumbrecht, Charlotte Sun, Marilyn Huang, Andrea Milbourne, Diane Bodurka

Modeling treatment-dependent glioma growth including a dormant tumor cell subpopulation

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Marvin A. Böttcher, Janka Held-Feindt, Michael Synowitz, Ralph Lucius, Arne Traulsen, Kirsten Hattermann

A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer

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Azeez A. Fatai, Junaid Gamieldien

Chemoradiotherapy versus chemotherapy as adjuvant treatment for localized gastric cancer: a propensity score-matched analysis

• Open Access
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Daniel M. Girardi, Mariana A. de Lima, Gabriel C. B. Pereira, Marcelo V. Negrão, Rossana V. M. López, Fernanda C. Capareli, Jorge Sabbaga, Paulo Marcelo G. Hoff

Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells

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Chung-Ching Chio, Kung-Yen Chen, Cheng-Kuei Chang, Jian-Ying Chuang, Chih-Chung Liu, Shing-Hwa Liu, Ruei-Ming Chen

Digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts – a systematic review and meta-analysis

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Xuan-Anh Phi, Alberto Tagliafico, Nehmat Houssami, Marcel J. W. Greuter, Geertruida H. de Bock

Cancer patients’ knowledge about their disease and treatment before, during and after treatment: a prospective, longitudinal study

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Ola Berger, Bjørn Henning Grønberg, Jon Håvard Loge, Stein Kaasa, Kari Sand

The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model

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Patricia Luiza Nunes da Costa, David Wynne, Theodora Fifis, Linh Nguyen, Marcos Perini, Christopher Christophi

Pretreatment neutrophil to lymphocyte ratio in determining the prognosis of head and neck cancer: a meta-analysis

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Yalian Yu, Hongbo Wang, Aihui Yan, Hailong Wang, Xinyao Li, Jiangtao Liu, Wei Li

Sequential tests for monitoring methods to detect elevated incidence – a simulation study

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Tammo Konstantin Reinders, Joachim Kieschke, Antje Timmer, Verena Jürgens

Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma

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Frank K. Leusink, Eleftherios Koudounarakis, Michael H. Frank, Ronald Koole, Paul J. van Diest, Stefan M. Willems

Breast density and breast cancer-specific survival by detection mode

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Daniëlle van der Waal, André L. M. Verbeek, Mireille J. M. Broeders

Histo-epidemiological profile of breast cancers among women in the Central African Republic: about 174 cases

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Augustin Balekouzou, Ping Yin, Cavin Epi Bekolo, Christian Maucler Pamatika, Marceline Djeintote, Sylvain Wilfrid Nambei, Bertrand Ba-Mpoutou, Dieubeni Rawago Mandjiza, Chang Shu, Minghui Yin, Tingting Qing, Boniface Koffi

Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study

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Christine Barul, Matthieu Carton, Loredana Radoï, Gwenn Menvielle, Corinne Pilorget, Simona Bara, Isabelle Stücker, Danièle Luce, Anne-Valérie Guizard, Arlette Danzon, Anne-Sophie Woronoff, Michel Velten, Antoine Buemi, Émilie Marrer, Brigitte Trétarre, Marc Colonna, Patricia Delafosse, Paolo Bercelli, Florence Molinié, Simona Bara, Bénédicte Lapotre-Ledoux, Nicole Raverdy, Sylvie Cénée, Oumar Gaye, Florence Guida, Farida Lamkarkach, Loredana Radoï, Marie Sanchez, Isabelle Stücker, Matthieu Carton, Diane Cyr, Annie Schmaus, Joëlle Févotte, Corinne Pilorget, Gwenn Menvielle, Danièle Luce

The PiGeOn project: protocol for a longitudinal study examining psychosocial, behavioural and ethical issues and outcomes in cancer tumour genomic profiling

• Open Access
• Study protocol

Megan Best, Ainsley J. Newson, Bettina Meiser, Ilona Juraskova, David Goldstein, Kathy Tucker, Mandy L. Ballinger, Dominique Hess, Timothy E. Schlub, Barbara Biesecker, Richard Vines, Kate Vines, David Thomas, Mary-Anne Young, Jacqueline Savard, Chris Jacobs, Phyllis Butow

Using a nomogram based on preoperative serum fibrinogen levels to predict recurrence of papillary thyroid carcinoma

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Lei Jianyong, Li Zhihui, Gong Rixiang, Zhu Jingqiang

Adjuvant trastuzumab duration trials in HER2 positive breast cancer – what results would be practice-changing? Persephone investigator questionnaire prior to primary endpoint results

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Louise Hiller, Janet A. Dunn, Shrushma Loi, Anne-Laure Vallier, Donna L. Howe, David A. Cameron, David Miles, Andrew M. Wardley, Helena M. Earl

Sorafenib versus Transarterial chemoembolization for advanced-stage hepatocellular carcinoma: a cost-effectiveness analysis

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Shuling Chen, Zhenwei Peng, Mengchao Wei, Weifeng Liu, Zihao Dai, Haibo Wang, Jie Mei, Mingfong Cheong, Hanmei Zhang, Ming Kuang

Aggressive primary treatments with favourable 5-year survival for screen-interval breast cancers

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Gautier Defossez, Alexandre Quillet, Pierre Ingrand

What is the impact of rerouting a cancer diagnosis from emergency presentation to GP referral on resource use and survival? Evidence from a population-based study

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Mauro Laudicella, Brendan Walsh, Elaine Burns, Paolo Li Donni, Peter C. Smith

Radiotherapy-induced anti-tumor immune response and immune-related adverse events in a case of recurrent nasopharyngeal carcinoma undergoing anti-PD-1 immunotherapy

• Open Access
• Case report

T. Finazzi, T. Rordorf, K. Ikenberg, G. F. Huber, M. Guckenberger, H. I. Garcia Schueler

Apatinib for advanced sarcoma: results from multiple institutions’ off-label use in China

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Lu Xie, Wei Guo, Ye Wang, Taiqiang Yan, Tao Ji, Jie Xu

Dynamic imaging and pathological changes in pig liver after MR-guided microwave ablation

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Jun Dong, Xiaojing Geng, Yadi Yang, Xiuyu Cai, Pili Hu, Liangping Xia, Bei Zhang, Peihong Wu

The first case of SMARCB1 (INI1) - deficient squamous cell carcinoma of the pleura: a case report

• Open Access
• Case report

Kazushi Yoshida, Yutaka Fujiwara, Yasushi Goto, Takashi Kohno, Akihiko Yoshida, Koji Tsuta, Yuichiro Ohe

Comparative analysis of histologically classified oligodendrogliomas reveals characteristic molecular differences between subgroups

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Chris Lauber, Barbara Klink, Michael Seifert

CTHRC1 induces non-small cell lung cancer (NSCLC) invasion through upregulating MMP-7/MMP-9

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Weiling He, Hui Zhang, Yuefeng Wang, Yanbin Zhou, Yifeng Luo, Yongmei Cui, Neng Jiang, Wenting Jiang, Han Wang, Di Xu, Shuhua Li, Zhuo Wang, Yangshan Chen, Yu Sun, Yang Zhang, Hsian-Rong Tseng, Xuenong Zou, Liantang Wang, Zunfu Ke

Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in chemoprevention of hepatocellular carcinoma: a nationwide high-risk cohort study

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Cheng-Maw Ho, Chih-Hsin Lee, Ming-Chia Lee, Jun-Fu Zhang, Jann-Yuan Wang, Rey-Heng Hu, Po-Huang Lee

Trends in the contemporary incidence of colorectal cancer and patient characteristics in the United Kingdom: a population-based cohort study using The Health Improvement Network

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Lucía Cea Soriano, Montse Soriano-Gabarró, Luis A. García Rodríguez

Survival analysis of patients with invasive extramammary Paget disease: implications of anatomic sites

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Haijun Yao, Minkai Xie, Shibo Fu, Jianhua Guo, Yubing Peng, Zhikang Cai, Yueqing Jiang, Dachao Zheng, Zhong Wang

MiR-30a-5p confers cisplatin resistance by regulating IGF1R expression in melanoma cells

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Yuxia Li, Jie Zhang, Yajing Liu, Bingyue Zhang, Fubo Zhong, Shubin Wang, Zhengyu Fang

Identification of methylation sites and signature genes with prognostic value for luminal breast cancer

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Bin Xiao, Lidan Chen, Yongli Ke, Jianfeng Hang, Ling Cao, Rong Zhang, Weiyun Zhang, Yang Liao, Yang Gao, Jianyun Chen, Li Li, Wenbo Hao, Zhaohui Sun, Linhai Li

Serum leucine-rich alpha-2-glycoprotein-1 with fucosylated triantennary N-glycan: a novel colorectal cancer marker

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Eiji Shinozaki, Kazuhiro Tanabe, Takashi Akiyoshi, Tomohiro Tsuchida, Yuko Miyazaki, Nozomi Kojima, Masahiro Igarashi, Masashi Ueno, Mitsukuni Suenaga, Nobuyuki Mizunuma, Kensei Yamaguchi, Konosuke Nakayama, Sadayo Iijima, Toshiharu Yamaguchi

Bexarotene inhibits the viability of non-small cell lung cancer cells via slc10a2/PPARγ/PTEN/mTOR signaling pathway

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Xinghao Ai, Feng Mao, Shengping Shen, Yang Shentu, Jiejun Wang, Shun Lu

In silico cancer research towards 3R

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• Debate

Claire Jean-Quartier, Fleur Jeanquartier, Igor Jurisica, Andreas Holzinger

Bile acids at neutral and acidic pH induce apoptosis and gene cleavages in nasopharyngeal epithelial cells: implications in chromosome rearrangement

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Sang-Nee Tan, Sai-Peng Sim

The incidence of acute oxaliplatin-induced neuropathy and its impact on treatment in the first cycle: a systematic review

• Open Access
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Endale Gebreegziabher Gebremedhn, Peter John Shortland, David Anthony Mahns

Evaluation of efficacy and safety for Brucea javanica oil emulsion in the control of the malignant pleural effusions via thoracic perfusion

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Dai Fuhong, Gao Xiang, Li Haiying, Wang Jiangye, Gao Xueming, Chai Wenxiao

BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway

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Melissa M. Ledet, Robyn Anderson, Rebecca Harman, Aaron Muth, Paul R. Thompson, Scott A. Coonrod, Gerlinde R. Van de Walle

Correction to: Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy

• Open Access
• Correction

Kim A. Brogden, Deepak Parashar, Andrea R. Hallier, Terry Braun, Fang Qian, Naiyer A. Rizvi, Aaron D. Bossler, Mohammed M. Milhem, Timothy A. Chan, Taher Abbasi, Shireen Vali

Population-level distribution and putative immunogenicity of cancer neoepitopes

• Open Access
• Technical advance

Mary A. Wood, Mayur Paralkar, Mihir P. Paralkar, Austin Nguyen, Adam J. Struck, Kyle Ellrott, Adam Margolin, Abhinav Nellore, Reid F. Thompson

Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer

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Hai-Ning Liu, Hao Wu, Yu-Jen Tseng, Yan-Jie Chen, Dan-Ying Zhang, Lin Zhu, Ling Dong, Xi-Zhong Shen, Tao-Tao Liu

Stereotactic body radiation therapy using a respiratory-gated volumetric-modulated arc therapy technique for small hepatocellular carcinoma

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Yuri Jeong, Jinhong Jung, Byungchul Cho, Jungwon Kwak, Chiyoung Jeong, Jong Hoon Kim, Jin-hong Park, So Yeon Kim, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Sang Min Yoon

Prognostic value of serum CYFRA 21-1 1 in patients with anal canal squamous cell carcinoma treated with radio(chemo)therapy

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Mathieu Gauthé, Marion Richard-Molard, Eugénie Rigault, Bruno Buecher, Pascale Mariani, Dominique Bellet, Wulfran Cacheux, Astrid Lièvre

Non-endometrioid and high-grade endometrioid endometrial cancers show DNA fragmentation factor 40 (DFF40) and B-cell lymphoma 2 protein (BCL2) underexpression, which predicts disease-free and overall survival, but not DNA fragmentation factor 45 (DFF45) underexpression

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Tomasz Banas, Kazimierz Pitynski, Krzysztof Okon, Aleksandra Winiarska

ZBP-89 and Sp1 contribute to Bak expression in hepatocellular carcinoma cells

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Xia Kong, Pin Xu, Wei-Jie Cai, Huai-Gao Wang, Bin-Bin Li, Guo-Liang Huang, Zhi-Wei He, George Chen, Cai-Guo Ye

Impact of Myeloproliferative neoplasms on patients’ employment status and work productivity in the United States: results from the living with MPNs survey

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Jingbo Yu, Shreekant Parasuraman, Dilan Paranagama, Andrew Bai, Ahmad Naim, David Dubinski, Ruben Mesa

Micro-RNA-186-5p inhibition attenuates proliferation, anchorage independent growth and invasion in metastatic prostate cancer cells

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Dominique Z. Jones, M. Lee Schmidt, Suman Suman, Katharine R. Hobbing, Shirish S. Barve, Leila Gobejishvili, Guy Brock, Carolyn M. Klinge, Shesh N. Rai, Jong Park, Geoffrey J. Clark, Rajesh Agarwal, LaCreis R. Kidd

Diabetes mellitus and the risk of gastrointestinal cancer in women compared with men: a meta-analysis of cohort studies

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Hong-juan FANG, Shao-bo SHAN, Yu-hao ZHOU, Li-yong ZHONG

MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?

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Hussein H. K. Abbas, Kheloud M. H. Alhamoudi, Mark D. Evans, George D. D. Jones, Steven S. Foster

Working to improve the management of sarcoma patients across Europe: a policy checklist

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• Debate

Bernd Kasper, Estelle Lecointe-Artzner, Suzanne Wait, Shannon Boldon, Roger Wilson, Alessandro Gronchi, Claudia Valverde, Mikael Eriksson, Sarah Dumont, Nora Drove, Athanasia Kanli, Markus Wartenberg

High OX40 expression in recurrent ovarian carcinoma is indicative for response to repeated chemotherapy

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Michaela Ramser, Simone Eichelberger, Silvio Däster, Benjamin Weixler, Marko Kraljević, Robert Mechera, Athanasios Tampakis, Tarik Delko, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano, Raoul A. Droeser, Gad Singer

Active DNA end processing in micronuclei of ovarian cancer cells

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Zizhi Tang, Juan Yang, Xin Wang, Ming Zeng, Jing Wang, Ao Wang, Mingcai Zhao, Liandi Guo, Cong Liu, Dehua Li, Jie Chen

Outcomes of pathologic stage T3a renal cell carcinoma up-staged from small renal tumor: emphasis on partial nephrectomy

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Hakmin Lee, Minseung Lee, Sang Eun Lee, Seok-Soo Byun, Hyeon Hoe Kim, Cheol Kwak, Sung Kyu Hong

Predictive value of dynamic change of haemoglobin levels during therapy on treatment outcomes in patients with Enneking stage IIB extremity osteosarcoma

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Jian Tu, Lili Wen, Zijun Huo, Bo Wang, Yongqian Wang, Hongyi Liao, Weihai Liu, Xian Zhong, Jianqiu Kong, Mengqi Wang, Gang Huang, Junqiang Yin, Xianbiao Xie, Jingnan Shen

Helicase-like transcription factor expression is associated with a poor prognosis in Non-Small-Cell Lung Cancer (NSCLC)

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Ludovic Dhont, Melania Pintilie, Ethan Kaufman, Roya Navab, Shirley Tam, Arsène Burny, Frances Shepherd, Alexandra Belayew, Ming-Sound Tsao, Céline Mascaux

RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas

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Pilar López-Nieva, Pablo Fernández-Navarro, Concepción Vaquero-Lorenzo, María Villa-Morales, Osvaldo Graña-Castro, María Ángeles Cobos-Fernández, José Luis López-Lorenzo, Pilar Llamas, Laura González-Sanchez, Isabel Sastre, Marina Pollan, Marcos Malumbres, Javier Santos, José Fernández-Piqueras

EP3 (prostaglandin E2 receptor 3) expression is a prognostic factor for progression-free and overall survival in sporadic breast cancer

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Anna Semmlinger, Viktoria von Schoenfeldt, Verena Wolf, Alexandra Meuter, Theresa Maria Kolben, Thomas Kolben, Christine Zeder-Goess, Florian Weis, Julia Gallwas, Rachel Wuerstlein, Kerstin Hermelink, Elisa Schmoeckel, Nadia Harbeck, Doris Mayr, Sven Mahner, Udo Jeschke, Nina Ditsch

The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

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Sunhyo Ryu, Yun Jeong Ahn, Chakeong Yoon, Jeong Hwan Chang, Yoonkyung Park, Tae-Hyoung Kim, Amanda R. Howland, Cheryl A. Armstrong, Peter I. Song, Ae Ran Moon

Loss of ZG16 is associated with molecular and clinicopathological phenotypes of colorectal cancer

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Hui Meng, Wencai Li, Lisa A. Boardman, Liang Wang

Valproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal

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Muyun Wei, Shaowei Mao, Guoliang Lu, Liang Li, Xiaopeng Lan, Zhongxian Huang, Yougen Chen, Miaoqing Zhao, Yueran Zhao, Qinghua Xia

Medical expenses of urban Chinese patients with stomach cancer during 2002–2011: a hospital-based multicenter retrospective study

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Xiao-Jie Sun, Ju-Fang Shi, Lan-Wei Guo, Hui-Yao Huang, Neng-Liang Yao, Ji-Yong Gong, Ya-Wen Sun, Guo-Xiang Liu, A-Yan Mao, Xian-Zhen Liao, Ya-Na Bai, Jian-Song Ren, Xin-Yu Zhu, Jin-Yi Zhou, Ling Mai, Bing-Bing Song, Yu-Qin Liu, Lin Zhu, Ling-Bin Du, Qi Zhou, Xiao-Jing Xing, Pei-An Lou, Xiao-Hua Sun, Xiao Qi, Yuanzheng Wang, Rong Cao, Ying Ren, Li Lan, Kai Zhang, Jie He, Jia-Lin Wang, Min Dai

The oncogenic effects of HES1 on salivary adenoid cystic carcinoma cell growth and metastasis

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Xiao-Yu Huang, Rui-Huan Gan, Jian Xie, Lin She, Yong Zhao, Lin-Can Ding, Bo-Hua Su, Da-Li Zheng, You-Guang Lu

Correction to: Sepsis increases perioperative metastases in a murine model

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• Correction

Lee-Hwa Tai, Abhirami A. Ananth, Rashmi Seth, Almohanad Alkayyal, Jiqing Zhang, Christiano Tanese de Souza, Phillip Staibano, Michael A. Kennedy, Rebecca C. Auer

Effect of metformin use on the risk and prognosis of endometrial cancer: a systematic review and meta-analysis

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Danxia Chu, Jie Wu, Kaili Wang, Mengling Zhao, Chunfang Wang, Liuxia Li, Ruixia Guo

Salivary extracellular vesicle-associated miRNAs as potential biomarkers in oral squamous cell carcinoma

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Chiara Gai, Francesco Camussi, Roberto Broccoletti, Alessio Gambino, Marco Cabras, Luca Molinaro, Stefano Carossa, Giovanni Camussi, Paolo G. Arduino

Predictive values of upper gastrointestinal cancer alarm symptoms in the general population: a nationwide cohort study

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Sanne Rasmussen, Peter Fentz Haastrup, Kirubakaran Balasubramaniam, René DePont Christensen, Jens Søndergaard, Dorte Ejg Jarbøl

Small cell and non small cell lung cancer form metastasis on cellular 4D lung model

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Dhruva K. Mishra, Ross A. Miller, Kristi A. Pence, Min P. Kim

Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for the treatment of malignant mesothelioma

• Open Access
• Research article

Urs Giger-Pabst, Cédric Demtröder, Thomas A. Falkenstein, Mehdi Ouaissi, Thorsten O. Götze, Günther A. Rezniczek, Clemens B. Tempfer

Prognostic value of systemic inflammatory markers in ovarian Cancer: a PRISMA-compliant meta-analysis and systematic review

• Open Access
• Research article

Ying Zhu, Sanqin Zhou, Yang Liu, Lingyun Zhai, Xiwen Sun

Improving quality of life through the routine use of the patient concerns inventory for head and neck cancer patients: a cluster preference randomized controlled trial

• Open Access
• Study protocol

Simon N. Rogers, Derek Lowe, Cher Lowies, Seow Tien Yeo, Christine Allmark, Dominic Mcavery, Gerald M. Humphris, Robert Flavel, Cherith Semple, Steven J. Thomas, Anastasios Kanatas

Dietary patterns, BCMO1 polymorphisms, and primary lung cancer risk in a Han Chinese population: a case-control study in Southeast China

• Open Access
• Research article

Fei He, Ren-dong Xiao, Tao Lin, Wei-min Xiong, Qiu-ping Xu, Xu Li, Zhi-qiang Liu, Bao-chang He, Zhi-jian Hu, Lin Cai

Incidence, pattern and prognosis of brain metastases in patients with metastatic triple negative breast cancer

• Open Access
• Research article

Jia Jin, Yu Gao, Jian Zhang, Leiping Wang, Biyun Wang, Jun Cao, Zhimin Shao, Zhonghua Wang

AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre study

• Open Access
• Research article

Veronika Seebacher, Stephan Polterauer, Alexander Reinthaller, Heinz Koelbl, Regina Achleitner, Astrid Berger, Nicole Concin

Radiosensitization of clioquinol and zinc in human cancer cell lines

• Open Access
• Research article

Shan Lu, Yuan Ke, Chaoyan Wu, Yahua Zhong, Conghua Xie, Yunfeng Zhou, Fuxiang Zhou, Haijun Yu

Survival after recurrence in patients with gastric cancer who receive S-1 adjuvant chemotherapy: exploratory analysis of the ACTS-GC trial

• Open Access
• Research article

Seiji Ito, Yasuo Ohashi, Mitsuru Sasako

Evaluation of PET and laparoscopy in STagIng advanced gastric cancer: a multicenter prospective study (PLASTIC-study)

• Open Access
• Study protocol

H. J. F. Brenkman, E. C. Gertsen, E. Vegt, R. van Hillegersberg, M. I. van Berge Henegouwen, S. S. Gisbertz, M. D. P. Luyer, G. A. P. Nieuwenhuijzen, J. J. B. van Lanschot, S. M. Lagarde, W. O. de Steur, H. H. Hartgrink, J. H. M. B. Stoot, K. W. E. Hulsewe, E. J. Spillenaar Bilgen, M. J. van Det, E. A. Kouwenhoven, D. L. van der Peet, F. Daams, J. W. van Sandick, N. C. T. van Grieken, J. Heisterkamp, B. van Etten, J. W. Haveman, J. P. Pierie, F. Jonker, A. Y. Thijssen, E. J. T. Belt, P. van Duijvendijk, E. Wassenaar, H. W. M. van Laarhoven, F. J. Wessels, N. Haj Mohammad, H. F. van Stel, G. W. J. Frederix, P. D. Siersema, J. P. Ruurda

Stereotactic body radiation therapy as an effective and safe treatment for small hepatocellular carcinoma

• Open Access
• Research article

Tao Zhang, Jing Sun, Weiping He, Huan Li, Junjie Piao, Huijun Xu, Xuezhang Duan

Genetic variants in ATM, H2AFX and MRE11 genes and susceptibility to breast cancer in the polish population

• Open Access
• Research article

Marta Podralska, Iwona Ziółkowska-Suchanek, Magdalena Żurawek, Agnieszka Dzikiewicz-Krawczyk, Ryszard Słomski, Jerzy Nowak, Agnieszka Stembalska, Karolina Pesz, Maria Mosor

Retrospective analysis of the impact of anthracycline dose reduction and chemotherapy delays on the outcomes of early breast cancer molecular subtypes

• Open Access
• Research article

Sigita Liutkauskiene, Saulius Grizas, Kristina Jureniene, Jorune Suipyte, Akvile Statnickaite, Elona Juozaityte

The PiGeOn project: protocol of a longitudinal study examining psychosocial and ethical issues and outcomes in germline genomic sequencing for cancer

• Open Access
• Study protocol

Megan Best, Ainsley J. Newson, Bettina Meiser, Ilona Juraskova, David Goldstein, Kathy Tucker, Mandy L. Ballinger, Dominique Hess, Timothy E. Schlub, Barbara Biesecker, Richard Vines, Kate Vines, David Thomas, Mary-Anne Young, Jacqueline Savard, Chris Jacobs, Phyllis Butow

Chemotherapy for metastatic colon cancer: No effect on survival when the dose is reduced due to side effects

• Open Access
• Research article

Stefan Munker, Michael Gerken, Petra Fest, Claudia Ott, Elisabeth Schnoy, Stefan Fichtner-Feigl, Philipp Wiggermann, Martin Vogelhuber, Wolfgang Herr, Christian Stroszczynski, Hans Jürgen Schlitt, Matthias Evert, Michael Reng, Monika Klinkhammer-Schalke, Andreas Teufel

The COSMAM TRIAL a prospective cohort study of quality of life and cosmetic outcome in patients undergoing breast conserving surgery

• Open Access
• Study protocol

Coriene J. L. M. Catsman, Martinus A. Beek, Adri C. Voogd, Paul G. H. Mulder, Ernest J. T. Luiten

Treatment of pancreatic ductal adenocarcinoma with tumor antigen specific-targeted delivery of paclitaxel loaded PLGA nanoparticles

• Open Access
• Research article

Shu-ta Wu, Anthony J. Fowler, Corey B. Garmon, Adam B. Fessler, Joshua D. Ogle, Kajal R. Grover, Bailey C. Allen, Chandra D. Williams, Ru Zhou, Mahboubeh Yazdanifar, Craig A. Ogle, Pinku Mukherjee

First case of AML with rare chromosome translocations: a case report of twins

• Open Access
• Case report

Lin Wang, Yanhua Sun, Yanli Sun, Lingbin Meng, Xin Xu

Cost of Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS): prospective cohort study protocol

• Open Access
• Study protocol

Irene Teo, Ratna Singh, Chetna Malhotra, Semra Ozdemir, Rebecca A. Dent, Nesaretnam Barr Kumarakulasinghe, Wee Lee Yeo, Yin Bun Cheung, Rahul Malhotra, Ravindran Kanesvaran, Alethea Chung Pheng Yee, Noreen Chan, Huei Yaw Wu, Soh Mun Chin, Hum Yin Mei Allyn, Grace Meijuan Yang, Patricia Soek Hui Neo, Nivedita V. Nadkarni, Richard Harding, Eric A. Finkelstein

Low expression of c-Myc protein predicts poor outcomes in patients with hepatocellular carcinoma after resection

• Open Access
• Research article

Fei Ji, Zhi-heng Zhang, Yi Zhang, Shun-Li Shen, Qing-Hua Cao, Long-Juan Zhang, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang, Yun-Peng Hua

Oncological and reproductive outcomes of adenocarcinoma in situ of the cervix managed with the loop electrosurgical excision procedure

• Open Access
• Research article

Huimin Bai, Jun Liu, Qiuxi Wang, Ying Feng, Tong Lou, Shuzhen Wang, Yue Wang, Mulan Jin, Zhenyu Zhang

CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

• Open Access
• Research article

Chenlu Zhang, Zhi Li, Ling Xu, Xiaofang Che, Ti Wen, Yibo Fan, Ce Li, Shuo Wang, Yu Cheng, Xiaoxun Wang, Xiujuan Qu, Yunpeng Liu

Radiogenic angiosarcoma of the breast: case report and systematic review of the literature

• Open Access
• Case report

Askin Dogan, Peter Kern, Beate Schultheis, Günther Häusler, Günther A. Rezniczek, Clemens B. Tempfer

Cost-effectiveness and budget impact analyses of a colorectal cancer screening programme in a high adenoma prevalence scenario using MISCAN-Colon microsimulation model

• Open Access
• Research article

Arantzazu Arrospide, Isabel Idigoras, Javier Mar, Harry de Koning, Miriam van der Meulen, Myriam Soto-Gordoa, Jose Miguel Martinez-Llorente, Isabel Portillo, Eunate Arana-Arri, Oliver Ibarrondo, Iris Lansdorp-Vogelaar

Impact of differences in adenoma and proximal serrated polyp detection rate on the long-term effectiveness of FIT-based colorectal cancer screening

• Open Access
• Research article

Maxime E. S. Bronzwaer, Marjolein J. E. Greuter, Arne G. C. Bleijenberg, Joep E. G. IJspeert, Evelien Dekker, Veerle M. H. Coupé

Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity

• Open Access
• Research article

Catja Freiburghaus, Venera Kuci Emruli, Angelica Johansson, Christian Winther Eskelund, Kirsten Grønbæk, Roger Olsson, Fredrik Ek, Mats Jerkeman, Sara Ek

Amphotericin B suppresses M2 phenotypes and B7-H1 expression in macrophages to prevent Raji cell proliferation

• Open Access
• Research article

Jing Zhang, Dongqing Cao, Shuangquan Yu, Lingchao Chen, Daolin Wei, Chang Shen, Lin Zhuang, Qian Wang, Xiaoping Xu, Yin Tong

Impact of clinical trial participation on survival in patients with castration-resistant prostate cancer: a multi-center analysis

• Open Access
• Research article

Kyo Chul Koo, Jong Soo Lee, Jong Won Kim, Kyung Suk Han, Kwang Suk Lee, Do Kyung Kim, Yoon Soo Ha, Koon Ho Rha, Sung Joon Hong, Byung Ha Chung

Reduction of MHC-I expression limits T-lymphocyte-mediated killing of Cancer-initiating cells

• Open Access
• Research article

Brian J. Morrison, Jason C. Steel, John C. Morris

FOLFOX activity in a rare case of metastatic colonic adenocarcinoma of the tongue: a case report

• Open Access
• Kolorektales Karzinom
• Case report

Clizia Zichi, Marco Tampellini, Marcello Tucci, Cristina Sonetto, Chiara Baratelli, Maria P. Brizzi, Giorgio V. Scagliotti

Putative cancer stem cells may be the key target to inhibit cancer cell repopulation between the intervals of chemoradiation in murine mesothelioma

• Open Access
• Research article

Licun Wu, Walter Blum, Chang-Qi Zhu, Zhihong Yun, Laszlo Pecze, Mikihiro Kohno, Mei-Lin Chan, Yidan Zhao, Emanuela Felley-Bosco, Beat Schwaller, Marc de Perrot

Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq

• Open Access
• Research article

Shingo Maeda, Hirotaka Tomiyasu, Masaya Tsuboi, Akiko Inoue, Genki Ishihara, Takao Uchikai, James K. Chambers, Kazuyuki Uchida, Tomohiro Yonezawa, Naoaki Matsuki

Genes and functions from breast cancer signatures

• Open Access
• Research article

Shujun Huang, Leigh Murphy, Wayne Xu

Computerized tomography findings in calcified signet-ring gastric cancer receiving chemotherapy: a case report

• Open Access
• Case report

Ting Wang, Zhi-Yong Lu, Xin-Fei Tu, Shui-Hong Zhang, Fang Huang, Long Huang

Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter

• Open Access
• Research article

Walter Blum, László Pecze, Janine Wörthmüller Rodriguez, Martine Steinauer, Beat Schwaller

The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study

• Open Access
• Research article

Stephan P. Bauersfeld, Christian S. Kessler, Manfred Wischnewsky, Annette Jaensch, Nico Steckhan, Rainer Stange, Barbara Kunz, Barbara Brückner, Jalid Sehouli, Andreas Michalsen

Investigation of the SLC22A23 gene in laryngeal squamous cell carcinoma

• Open Access
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Seda Ekizoglu, Didem Seven, Turgut Ulutin, Jalal Guliyev, Nur Buyru

Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized

• Open Access
• Research article

Morten Beck Rye, Helena Bertilsson, Maria K. Andersen, Kjersti Rise, Tone F. Bathen, Finn Drabløs, May-Britt Tessem

SMAD4 and NF1 mutations as potential biomarkers for poor prognosis to cetuximab-based therapy in Chinese metastatic colorectal cancer patients

• Open Access
• Research article

Zhu Mei, Yang W. Shao, Peinan Lin, Xiaomin Cai, Biao Wang, Yan Ding, Xiangyuan Ma, Xue Wu, Yewei Xia, Dongqin Zhu, Yongqian Shu, Zan Fu, Yanhong Gu

Development of a computational promoter with highly efficient expression in tumors

• Open Access
• Research article

Shu-Yi Ho, Bo-Hau Chang, Chen-Han Chung, Yu-Ling Lin, Cheng-Hsun Chuang, Pei-Jung Hsieh, Wei-Chih Huang, Nu-Man Tsai, Sheng-Chieh Huang, Yen-Ku Liu, Yu-Chih Lo, Kuang-Wen Liao

The accuracy of chemotherapy ascertainment among colorectal cancer patients in the surveillance, epidemiology, and end results registry program

• Open Access
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Mark A. Healy, Arden M. Morris, Paul Abrahamse, Kevin C. Ward, Ikuko Kato, Christine M. Veenstra

Incidence trends and patterns of breast cancer in Sri Lanka: an analysis of the national cancer database

• Open Access
• Research article

Ashan Fernando, Umesh Jayarajah, Saumyakala Prabashani, Eshani A. Fernando, Sanjeewa A. Seneviratne

Extra-capsular growth of lymph node metastasis correlates with poor prognosis and high SOX9 expression in gastric cancer

• Open Access
• Research article

Helena Link, Martin Angele, Miriam Schüller, Petra Ganschow, Lena Machetanz, Markus Guba, Jens Werner, Thomas Kirchner, Jens Neumann

Microsatellite instability testing in colorectal cancer using the QiaXcel advanced platform

• Open Access
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Isabel Förster, Michael Brockmann, Oliver Schildgen, Verena Schildgen

HPV-16 E7 expression up-regulates phospholipase D activity and promotes rapamycin resistance in a pRB-dependent manner

• Open Access
• Research article

Tatiana Rabachini, Enrique Boccardo, Rubiana Andrade, Katia Regina Perez, Suely Nonogaki, Iolanda Midea Cuccovia, Luisa Lina Villa

Comparison between intravenous chemotherapy and intra-arterial chemotherapy for retinoblastoma: a meta-analysis

• Open Access
• Research article

Qiuying Chen, Bin Zhang, Yuhao Dong, Xiaokai Mo, Lu Zhang, Wenhui Huang, Hua Jiang, Jiejun Xia, Shuixing Zhang

Distribution of human papilloma virus genotype prevalence in invasive cervical carcinomas and precancerous lesions in the Yangtze River Delta area, China

• Open Access
• Research article

Hongyun WANG, Xiaodong CHENG, Jing YE, Xiuyun XU, Ying HONG, Long SUI, Zhixue YOU, Xing XIE

Race is an independent predictor of survival in patients with soft tissue sarcoma of the extremities

• Open Access
• Research article

Alexander L. Lazarides, Julia D. Visgauss, Daniel P. Nussbaum, Cindy L. Green, Dan G. Blazer III, Brian E. Brigman, William C. Eward

Validation of the SNACOR clinical scoring system after transarterial chemoembolisation in patients with hepatocellular carcinoma

• Open Access
• Research article

Aline Mähringer-Kunz, Arndt Weinmann, Irene Schmidtmann, Sandra Koch, Sebastian Schotten, Daniel Pinto dos Santos, Michael Bernhard Pitton, Christoph Dueber, Peter Robert Galle, Roman Kloeckner

Survival and clinical outcomes of patients with melanoma brain metastasis in the era of checkpoint inhibitors and targeted therapies

• Open Access
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Elham Vosoughi, Jee Min Lee, James R. Miller, Mehdi Nosrati, David R. Minor, Roy Abendroth, John W. Lee, Brian T. Andrews, Lewis Z. Leng, Max Wu, Stanley P. Leong, Mohammed Kashani-Sabet, Kevin B. Kim

Assessment of the quality of patient-oriented information over internet on testicular cancer

• Open Access
• Research article

Anton S. Prasanth, Umesh Jayarajah, Ranganathan Mohanappirian, Sanjeewa A. Seneviratne

Characteristics of patients with missing information on stage: a population-based study of patients diagnosed with colon, lung or breast cancer in England in 2013

• Open Access
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Chiara Di Girolamo, Sarah Walters, Sara Benitez Majano, Bernard Rachet, Michel P. Coleman, Edmund Njeru Njagi, Melanie Morris

Clinically significant association of elevated expression of nuclear factor E2-related factor 2 expression with higher glucose uptake and progression of upper urinary tract cancer

• Open Access
• Research article

Akinori Nukui, Takahiro Narimatsu, Tsunehito Kambara, Hideyuki Abe, Setsu Sakamoto, Ken-Ichiro Yoshida, Takao Kamai

LYL1 gene amplification predicts poor survival of patients with uterine corpus endometrial carcinoma: analysis of the Cancer genome atlas data

• Open Access
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Se Ik Kim, Ji Won Lee, Nara Lee, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song, Jeong-Sun Seo

Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue

• Open Access
• Technical advance

Mylène A. Carrascal, Catarina Talina, Paula Borralho, A. Gonçalo Mineiro, Ana Raquel Henriques, Cláudia Pen, Manuela Martins, Sofia Braga, Robert Sackstein, Paula A. Videira

Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress

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Beate Hegge, Eva Sjøttem, Ingvild Mikkola

Smokers’ interest in a lung cancer screening programme: a national survey in England

• Open Access
• Research article

Samantha L. Quaife, Charlotte Vrinten, Mamta Ruparel, Samuel M. Janes, Rebecca J. Beeken, Jo Waller, Andy McEwen

NKX2.5 is expressed in papillary thyroid carcinomas and regulates differentiation in thyroid cells

• Open Access
• Research article

Ricardo Cortez Cardoso Penha, Luisa Aguirre Buexm, Fabiana Resende Rodrigues, Taciana Padilha de Castro, Maria Carolina S. Santos, Rodrigo Soares Fortunato, Denise P. Carvalho, Luciene C. Cardoso-Weide, Andrea C. F. Ferreira

PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways

• Open Access
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Dong-Dong Wu, Ying-Ran Gao, Tao Li, Da-Yong Wang, Dan Lu, Shi-Yu Liu, Ya Hong, Hui-Bin Ning, Jun-Ping Liu, Jia Shang, Jun-Feng Shi, Jian-She Wei, Xin-Ying Ji

NLRP3 promotes tumor growth and metastasis in human oral squamous cell carcinoma

• Open Access
• Research article

Han Wang, Qingqiong Luo, Xiaodong Feng, Ruiyang Zhang, Jiang Li, Fuxiang Chen

Prognostic value of an automated bone scan index for men with metastatic castration-resistant prostate cancer treated with cabazitaxel

• Open Access
• Research article

Koichi Uemura, Yasuhide Miyoshi, Takashi Kawahara, Jikuya Ryosuke, Daisuke Yamashita, Shuko Yoneyama, Yumiko Yokomizo, Kazuki Kobayashi, Takeshi Kishida, Masahiro Yao, Hiroji Uemura

Laterally spreading tumour of the distal stomach: a case report

• Open Access
• Magenkarzinom
• Case report

Samiullah Khan, Lan-ping Zhu, Yujie Zhang, Xin Chen, Bang-mao Wang

Limb saving surgery for Ewing’s sarcoma of the distal tibia: a case report

• Open Access
• Case report

Naoki Mizoshiri, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Yuki Mori, Yusei Katsuyama, Daichi Hayashi, Yoshinobu Oka, Toshikazu Kubo

Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation

• Open Access
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Mark Barok, Maija Puhka, Gyorgy Vereb, Janos Szollosi, Jorma Isola, Heikki Joensuu

Rupture of a subungual glomus tumor of the finger

• Open Access
• Case report

Hui Lu, Li Feng Chen, Qiang Chen

Prognostic value of Dickkopf-1 and ß-catenin expression in advanced gastric cancer

• Open Access
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Soon Auck Hong, Su Hyun Yoo, Han Hong Lee, Der Sheng Sun, Hye Sung Won, Okran Kim, Yoon Ho Ko

C-Cbl reverses HER2-mediated tamoxifen resistance in human breast cancer cells

• Open Access
• Research article

Wei Li, Ling Xu, Xiaofang Che, Haizhou Li, Ye Zhang, Na Song, Ti Wen, Kezuo Hou, Yi Yang, Lu Zhou, Xing Xin, Lu Xu, Xue Zeng, Sha Shi, Yunpeng Liu, Xiujuan Qu, Yuee Teng

Upregulation of bone morphogenetic protein 1 is associated with poor prognosis of late-stage gastric Cancer patients

• Open Access
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Yung-Yu Hsieh, Shui-Yi Tung, Hung-Yu Pan, Chih-Wei Yen, Huang-Wei Xu, Yi-Fang Deng, Ying-Jhen Lin, Wan-Ting Hsu, Cheng-Shyong Wu, Chin Li

Performance of a quantitative fecal immunochemical test for detecting advanced colorectal neoplasia: a prospective cohort study

• Open Access
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Elizabeth G. Liles, Nancy Perrin, Ana G. Rosales, David H. Smith, Adrianne C. Feldstein, David M. Mosen, Theodore R. Levin

A randomized open-label study of guideline-driven antiemetic therapy versus single agent antiemetic therapy in patients with advanced cancer and nausea not related to anticancer treatment

• Open Access
• Research article

Janet Hardy, Helen Skerman, Paul Glare, Jennifer Philip, Peter Hudson, Geoffrey Mitchell, Peter Martin, Odette Spruyt, David Currow, Patsy Yates

VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

• Open Access
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Ming Zhang, Hua-Jin Pang, Wei Zhao, Yu-Fa Li, Li-Xu Yan, Zhong-Yi Dong, Xiao-Feng He

Primary cardiac myxofibrosarcoma: case report, literature review and pooled analysis

• Open Access
• Case report

Dandan Sun, Yupeng Wu, Yan Liu, Jun Yang

Telomere length differences between colorectal polyp subtypes: a colonoscopy-based case-control study

• Open Access
• Research article

Sheetal Hardikar, Andrea N. Burnett-Hartman, Amanda I. Phipps, Melissa P. Upton, Lee-Ching Zhu, Polly A. Newcomb

CRBP-1 over-expression is associated with poor prognosis in tongue squamous cell carcinoma

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Yue Chen, Tian Tian, Min-Jie Mao, Wei-Ye Deng, Hao Li

Combined neutrophil/platelet/lymphocyte/differentiation score predicts chemosensitivity in advanced gastric cancer

• Open Access
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Zhenhua Huang, Yantan Liu, Chen Yang, Xiaoyin Li, Changqie Pan, Jinjun Rao, Nailin Li, Wangjun Liao, Li Lin

Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?

• Open Access
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Hong Zhou, Lei Li, Peng Yang, Lin Yang, Jin E. Zheng, Ying Zhou, Yong Han

microRNA-451a regulates colorectal cancer proliferation in response to radiation

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Rebecca Ruhl, Shushan Rana, Katherine Kelley, Cristina Espinosa-Diez, Clayton Hudson, Christian Lanciault, Charles R. Thomas Jr, V. Liana Tsikitis, Sudarshan Anand

Emotional predictors of bowel screening: the avoidance-promoting role of fear, embarrassment, and disgust

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Lisa M. Reynolds, Ian P. Bissett, Nathan S. Consedine

The role of vimentin in the tumor marker Nup88-dependent multinucleated phenotype

• Open Access
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Masaki Makise, Hideaki Nakamura, Akihiko Kuniyasu

Vemurafenib in Chinese patients with BRAFV600 mutation–positive unresectable or metastatic melanoma: an open-label, multicenter phase I study

• Open Access
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Lu Si, Xiaoshi Zhang, Zhen Xu, Qiudi Jiang, Lilian Bu, Xuan Wang, Lili Mao, Weijiang Zhang, Nicole Richie, Jun Guo

Pretherapeutic FDG-PET total metabolic tumor volume predicts response to induction therapy in pediatric Hodgkin’s lymphoma

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Julian M. M. Rogasch, Patrick Hundsdoerfer, Frank Hofheinz, Florian Wedel, Imke Schatka, Holger Amthauer, Christian Furth

In vitro antineoplastic effects of auranofin in canine lymphoma cells

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Hong Zhang, Barbara J. Rose, Alex A. Pyuen, Douglas H. Thamm

Development and evaluation of oral Cancer quality-of-life questionnaire (QOL-OC)

• Open Access
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Min Nie, Chang Liu, Yi-Chen Pan, Chen-Xi Jiang, Bao-Ru Li, Xi-Jie Yu, Xin-Yu Wu, Shu-Ning Zheng

Chronophin regulates active vitamin B6 levels and transcriptomic features of glioblastoma cell lines cultured under non-adherent, serum-free conditions

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Markus Schulze, Maria Hutterer, Anja Sabo, Sabine Hoja, Julia Lorenz, Tanja Rothhammer-Hampl, Christel Herold-Mende, Lucia Floßbach, Camelia Monoranu, Markus J. Riemenschneider

Association of genetic polymorphisms CYP2A6*2 rs1801272 and CYP2A6*9 rs28399433 with tobacco-induced lung Cancer: case-control study in an Egyptian population

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• Research article

Nada Ezzeldin, Dalia El-Lebedy, Amira Darwish, Ahmed El Bastawisy, Shereen Hamdy Abd Elaziz, Mirhane Mohamed Hassan, Amal Saad-Hussein

The 21-gene Recurrence Score® assay predicts distant recurrence in lymph node-positive, hormone receptor-positive, breast cancer patients treated with adjuvant sequential epirubicin- and docetaxel-based or epirubicin-based chemotherapy (PACS-01 trial)

• Open Access
• Research article

Frédérique Penault-Llorca, Thomas Filleron, Bernard Asselain, Frederick L. Baehner, Pierre Fumoleau, Magali Lacroix-Triki, Joseph M. Anderson, Carl Yoshizawa, Diana B. Cherbavaz, Steven Shak, Lise Roca, Christine Sagan, Jérôme Lemonnier, Anne-Laure Martin, Henri Roché

Update on the types and usage of liquid biopsies in the clinical setting: a systematic review

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Borros Arneth

Cytoreductive treatment patterns among US veterans with polycythemia vera

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Shreekant Parasuraman, Jingbo Yu, Dilan Paranagama, Sulena Shrestha, Li Wang, Onur Baser, Robyn Scherber

Pancreatic ductal adenocarcinoma can be detected by analysis of volatile organic compounds (VOCs) in alveolar air

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Andrea Princivalle, Lorenzo Monasta, Giovanni Butturini, Claudio Bassi, Luigi Perbellini

Neuroendocrine carcinoma of the cervix: a systematic review of the literature

• Open Access
• Research article

Clemens B. Tempfer, Iris Tischoff, Askin Dogan, Ziad Hilal, Beate Schultheis, Peter Kern, Günther A. Rezniczek

PET/CT incidental detection of second tumor in patients investigated for pancreatic neoplasms

• Open Access
• Research article

Lucia Moletta, Sergio Bissoli, Alberto Fantin, Nicola Passuello, Michele Valmasoni, Cosimo Sperti

Metabolomic profiles in breast cancer:a pilot case-control study in the breast cancer family registry

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• Research article

Marcelle M. Dougan, Yuqing Li, Lisa W. Chu, Robert W. Haile, Alice S. Whittemore, Summer S. Han, Steven C. Moore, Joshua N. Sampson, Irene L. Andrulis, Esther M. John, Ann W. Hsing

Neuropilin-1 promotes the oncogenic Tenascin-C/integrin β3 pathway and modulates chemoresistance in breast cancer cells

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• Research article

Adviti Naik, Aida Al-Yahyaee, Nada Abdullah, Juda-El Sam, Noura Al-Zeheimi, Mahmoud W. Yaish, Sirin A. Adham

Impact of the treatment of pancreatic exocrine insufficiency on survival of patients with unresectable pancreatic cancer: a retrospective analysis

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Juan Enrique Domínguez-Muñoz, Laura Nieto-Garcia, Javier López-Díaz, Jose Lariño-Noia, Ihab Abdulkader, Julio Iglesias-Garcia

M1 macrophage recruitment correlates with worse outcome in SHH Medulloblastomas

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Chanhee Lee, Joongyub Lee, Seung Ah Choi, Seung-Ki Kim, Kyu-Chang Wang, Sung-Hye Park, Se Hoon Kim, Ji Yeoun Lee, Ji Hoon Phi

Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis

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• Research article

T. Zhang, A. Kastrenopoulou, Q. Larrouture, N. A. Athanasou, H. J. Knowles

Incidence of breast and colorectal cancer among immigrants in Ontario, Canada: a retrospective cohort study from 2004-2014

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Jennifer Shuldiner, Ying Liu, Aisha Lofters

Korean Society of Coloproctology (KSCP) trial of cONsolidation Chemotherapy for Locally advanced mid or low rectal cancer after neoadjUvant concurrent chemoraDiothErapy: a multicenter, randomized controlled trial (KONCLUDE)

• Open Access
• Study protocol

Chang Woo Kim, Byung Mo Kang, Ik Yong Kim, Ji Yeon Kim, Sun Jin Park, Won Cheol Park, Ki Beom Bae, Byung-Noe Bae, Seong Kyu Baek, Seung Hyuk Baik, Gyung Mo Son, Yoon Suk Lee, Suk-Hwan Lee

Histone methyltransferase SETDB1 promotes cells proliferation and migration by interacting withTiam1 in hepatocellular carcinoma

• Open Access
• Research article

Yuqin Zhang, Jing Huang, Qisheng Li, Keli Chen, Yonghao Liang, Zetao Zhan, Feng Ye, Wen Ni, Longhua Chen, Yi Ding

Cancer incidence in Yemen from 1997 to 2011: a report from the Aden cancer registry

• Open Access
• Research article

Amen Ahmed Bawazir

Elevated serum RAS p21 is an independent prognostic factor in metastatic breast cancer

• Open Access
• Research article

Malgorzata Banys-Paluchowski, Tanja Fehm, Wolfgang Janni, Bahriye Aktas, Peter A. Fasching, Sabine Kasimir-Bauer, Karin Milde-Langosch, Klaus Pantel, Brigitte Rack, Sabine Riethdorf, Erich-Franz Solomayer, Isabell Witzel, Volkmar Müller

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

• Open Access
• Research article

Eszter Molnár, Dominika Rittler, Marcell Baranyi, Michael Grusch, Walter Berger, Balázs Döme, József Tóvári, Clemens Aigner, József Tímár, Tamás Garay, Balázs Hegedűs

Spontaneous renal hemorrhage secondary to choriocarcinoma in a man with congenital hypospadias and cryptorchidism: a case report and literature review

• Open Access
• Case report

Yi Li, Gang Chen, Han Chen, Shuang Wen, Chao-yu Xiong, Zi-yi Yang, Yun-xiao Zhu, Nathan Jeffreys

Two successful pregnancies following fertility preservation in a patient with anaplastic astrocytoma: a case report

• Open Access
• Astrozytom
• Case report

Alexandra Peyser, Sara L. Bristow, Avner Hershlag

Predictors of adverse pathologic features after radical prostatectomy in low-risk prostate cancer

• Open Access
• Research article

Jae Won Park, Dong Hoon Koh, Won Sik Jang, Kang Su Cho, Won Sik Ham, Koon Ho Rha, Sung Joon Hong, Young Deuk Choi

Clinical decision making in cancer care: a review of current and future roles of patient age

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Eirik Joakim Tranvåg, Ole Frithjof Norheim, Trygve Ottersen

Phase II study of adjuvant chemotherapy with S1 plus oxaliplatin for Chinese patients with gastric cancer

• Open Access
• Research article

Guoxiu Wang, Jiuda Zhao, Yan Song, Wen Zhang, Yongkun Sun, Aiping Zhou, Jing Huang, Feng Du, Lin Yang

18FDG-PET-CT identifies histopathological non-responders after neoadjuvant chemotherapy in locally advanced gastric and cardia cancer: cohort study

• Open Access
• Research article

Paul M. Schneider, Dilmurodjon Eshmuminov, Tamara Rordorf, Diana Vetter, Patrick Veit-Haibach, Achim Weber, Peter Bauerfeind, Panagiotis Samaras, Kuno Lehmann

Unmasking of intracranial metastatic melanoma during ipilimumab/nivolumab therapy: case report and literature review

• Open Access
• Case report

Marin A. McDonald, Parag Sanghvi, Julie Bykowski, Gregory A. Daniels

PDXliver: a database of liver cancer patient derived xenograft mouse models

• Open Access
• Database

Sheng He, Bo Hu, Chao Li, Ping Lin, Wei-Guo Tang, Yun-Fan Sun, Fang-You-Min Feng, Wei Guo, Jia Li, Yang Xu, Qian-Lan Yao, Xin Zhang, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Yi-Xue Li, Hong Li, Xin-Rong Yang

Predicting multi-level drug response with gene expression profile in multiple myeloma using hierarchical ordinal regression

• Open Access
• Research article

Xinyan Zhang, Bingzong Li, Huiying Han, Sha Song, Hongxia Xu, Yating Hong, Nengjun Yi, Wenzhuo Zhuang

The search for a melanoma-tailored chemotherapy in the new era of personalized therapy: a phase II study of chemo-modulating temozolomide followed by fotemustine and a cooperative study of GOIM (Gruppo Oncologico Italia Meridionale)

• Open Access
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Michele Guida, Stefania Tommasi, Sabino Strippoli, Maria Iole Natalicchio, Simona De Summa, Rosamaria Pinto, Antonio Cramarossa, Anna Albano, Salvatore Pisconti, Michele Aieta, Ruggiero Ridolfi, Amalia Azzariti, Gabriella Guida, Vito Lorusso, Giusepe Colucci

VEGF-121 plasma level as biomarker for response to anti-angiogenetic therapy in recurrent glioblastoma

• Open Access
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Maurizio Martini, Ivana de Pascalis, Quintino Giorgio D’Alessandris, Vincenzo Fiorentino, Francesco Pierconti, Hany El-Sayed Marei, Lucia Ricci-Vitiani, Roberto Pallini, Luigi Maria Larocca

The acceptability of high resolution anoscopy examination in patients attending a tertiary referral centre

• Open Access
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Anke De-Masi, Esther Davis, Tamzin Cuming, Noreen Chindawi, Francesca Pesola, Carmelina Cappello, Susan Chambers, Julie Bowring, Adam N. Rosenthal, Peter Sasieni, Mayura Nathan

Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy

• Open Access
• Research article

Vachiranee Limviphuvadh, Chee Seng Tan, Fumikazu Konishi, Piroon Jenjaroenpun, Joy Shengnan Xiang, Yuliya Kremenska, Yar Soe Mu, Syn Nicholas, Lee Soo Chin, Ross A. Soo, Frank Eisenhaber, Sebastian Maurer-Stroh, Wei Peng Yong

Mechanisms of immune evasion in breast cancer

• Open Access
• Debate

Joshua P. Bates, Roshanak Derakhshandeh, Laundette Jones, Tonya J. Webb

Uptake of three doses of HPV vaccine by primary school girls in Eldoret, Kenya; a prospective cohort study in a malaria endemic setting

• Open Access
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Hillary Mabeya, Sonia Menon, Steven Weyers, Violet Naanyu, Emily Mwaliko, Elijah Kirop, Omenge Orango, Heleen Vermandere, Davy Vanden Broeck

Prognostic value of total number of lymph nodes retrieved differs between left-sided colon cancer and right-sided colon cancer in stage III patients with colon cancer

• Open Access
• Research article

Lin Yang, Zhenchong Xiong, Qiankun Xie, Wenzhuo He, Shousheng Liu, Pengfei Kong, Chang Jiang, Guifang Guo, Liangping Xia

Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose

• Open Access
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Xiaoshan Zhou, Sophie Curbo, Fuqiang Li, Shuba Krishnan, Anna Karlsson

Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro

• Open Access
• Research article

Selvi Kunnimalaiyaan, Victoriana K. Schwartz, Iris Alao Jackson, T. Clark Gamblin, Muthusamy Kunnimalaiyaan

Advanced sporadic renal epithelioid angiomyolipoma: case report of an extraordinary response to sirolimus linked to TSC2 mutation

• Open Access
• Case report

Marta Espinosa, Juan Maria Roldán-Romero, Ignacio Duran, Enrique de Álava, María Apellaniz-Ruiz, Alberto Cascón, Carmen Garrigos, Mercedes Robledo, Cristina Rodriguez-Antona

Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala

• Open Access
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Hong Lou, Eduardo Gharzouzi, Sarita Polo Guerra, Joël Fokom Domgue, Julie Sawitzke, Guillermo Villagran, Lisa Garland, Joseph F. Boland, Sarah Wagner, Héctor Rosas, Jami Troxler, Heidi McMillen, Bailey Kessing, Enrique Alvirez, Miriam Castillo, Hesler Morales, Victor Argueta, Andert Rosingh, Femke J. H. B. van Aerde-van Nunen, Griselda Lopez, Herbert M. Pinedo, Mark Schiffman, Michael Dean, Roberto Orozco

Clinicopathological features, surgical strategy and prognosis of duodenal gastrointestinal stromal tumors: a series of 300 patients

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Zhen Liu, Gaozan Zheng, Jinqiang Liu, Shushang Liu, Guanghui Xu, Qiao Wang, Man Guo, Xiao Lian, Hongwei Zhang, Fan Feng

γ-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport

• Open Access
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Victoria E. Palau, Kanishka Chakraborty, Daniel Wann, Janet Lightner, Keely Hilton, Marianne Brannon, William Stone, Koyamangalath Krishnan

Knowledge towards cervical cancer prevention and screening practices among women who attended reproductive and child health clinic at Magu district hospital, Lake Zone Tanzania: a cross-sectional study

• Open Access
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Mabula M. Mabelele, John Materu, Faraja D. Ng’ida, Michael J. Mahande

BioPro-RCMI-1505 trial: multicenter study evaluating the use of a biodegradable balloon for the treatment of intermediate risk prostate cancer by intensity modulated radiotherapy; study protocol

• Open Access
• Study protocol

David Pasquier, Emilie Bogart, François Bonodeau, Thomas Lacornerie, Eric Lartigau, Igor Latorzeff

Patterns of care for anal cancer in the United States - a comparison between academic and community cancer centers

• Open Access
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Victor E. Pricolo, Matteo Bonvini, Carlo F. Abelli

A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain study

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Ersilia Lucenteforte, Laura Vagnoli, Alessandra Pugi, Giada Crescioli, Niccolò Lombardi, Roberto Bonaiuti, Maurizio Aricò, Sabrina Giglio, Andrea Messeri, Alessandro Mugelli, Alfredo Vannacci, Valentina Maggini

A computational study of hedgehog signalling involved in basal cell carcinoma reveals the potential and limitation of combination therapy

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Antoine Buetti-Dinh, Rebecca Jensen, Ran Friedman

ADAM-17 is a poor prognostic indicator for patients with hilar cholangiocarcinoma and is regulated by FoxM1

• Open Access
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Xiaodong Jiao, Wenlong Yu, Jianxin Qian, Ying Chen, Peilian Wei, Wenzheng Fang, Guanzhen Yu

The clinical implications of G1-G6 transcriptomic signature and 5-gene score in Korean patients with hepatocellular carcinoma

• Open Access
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Sung-Min Ahn, Farhan Haq, Inkeun Park, Jean-Charles Nault, Jessica Zucman-Rossi, Eunsil Yu

Increased systemic zonula occludens 1 associated with inflammation and independent biomarker in patients with hepatocellular carcinoma

• Open Access
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Amit Kumar Ram, Biju Pottakat, Balasubramaniyan Vairappan

Risk factors for esophageal fistula in thoracic esophageal squamous cell carcinoma invading adjacent organs treated with definitive chemoradiotherapy: a monocentric case-control study

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Takeshi Kawakami, Takahiro Tsushima, Katsuhiro Omae, Hirofumi Ogawa, Hiromichi Shirasu, Yosuke Kito, Yukio Yoshida, Satoshi Hamauchi, Akiko Todaka, Nozomu Machida, Tomoya Yokota, Kentaro Yamazaki, Akira Fukutomi, Yusuke Onozawa, Hirofumi Yasui

DNA methylation signatures of breast cancer in peripheral T-cells

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Surabhi Parashar, David Cheishvili, Niaz Mahmood, Ani Arakelian, Imrana Tanvir, Haseeb Ahmed Khan, Richard Kremer, Catalin Mihalcioiu, Moshe Szyf, Shafaat A. Rabbani

Development of a normal tissue complication probability (NTCP) model for radiation-induced hypothyroidism in nasopharyngeal carcinoma patients

• Open Access
• Research article

Ren Luo, Vincent W. C. Wu, Binghui He, Xiaoying Gao, Zhenxi Xu, Dandan Wang, Zhining Yang, Mei Li, Zhixiong Lin

Lynch syndrome-associated endometrial carcinoma with MLH1 germline mutation and MLH1 promoter hypermethylation: a case report and literature review

• Open Access
• Case report

Takanori Yokoyama, Kazuhiro Takehara, Nao Sugimoto, Keika Kaneko, Etsuko Fujimoto, Mika Okazawa-Sakai, Shinichi Okame, Yuko Shiroyama, Takashi Yokoyama, Norihiro Teramoto, Shozo Ohsumi, Shinya Saito, Kazuho Imai, Kokichi Sugano

The impact of pharmacokinetic gene profiles across human cancers

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Michael T. Zimmermann, Terry M. Therneau, Jean-Pierre A. Kocher

Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

• Open Access
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Xianling Gong, Zhihong Chen, Qinrui Han, Chunhui Chen, Linlin Jing, Yawei Liu, Liang Zhao, Xueqing Yao, Xuegang Sun

Modulation the crosstalk between tumor-associated macrophages and non-small cell lung cancer to inhibit tumor migration and invasion by ginsenoside Rh2

• Open Access
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Honglin Li, Nan Huang, Weikang Zhu, Jianchun Wu, Xiaohui Yang, Wenjing Teng, Jianhui Tian, Zhihong Fang, Yingbin Luo, Min Chen, Yan Li

Galectin-3 activates TLR4/NF-κB signaling to promote lung adenocarcinoma cell proliferation through activating lncRNA-NEAT1 expression

• Open Access
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Wu Zhou, Xing Chen, Qinghua Hu, Xuliang Chen, Yingji Chen, Lingjin Huang

Resveratrol induces autophagy-dependent apoptosis in HL-60 cells

• Open Access
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Yingying Fan, Jen-Fu Chiu, Jing Liu, Yan Deng, Cheng Xu, Jun Zhang, Guanwu Li

Alterations in NO- and PGI2- dependent function in aorta in the orthotopic murine model of metastatic 4T1 breast cancer: relationship with pulmonary endothelial dysfunction and systemic inflammation

• Open Access
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E. Buczek, A. Denslow, L. Mateuszuk, B. Proniewski, T. Wojcik, B. Sitek, A. Fedorowicz, A. Jasztal, E. Kus, A. Chmura- Skirlinska, R. Gurbiel, J. Wietrzyk, S. Chlopicki

Involvement of the CB2 cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212–2 in renal cell carcinoma

• Open Access
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Mohammed I. Khan, Anna A. Sobocińska, Klaudia K. Brodaczewska, Katarzyna Zielniok, Malgorzata Gajewska, Claudine Kieda, Anna M. Czarnecka, Cezary Szczylik

Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors

• Open Access
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Sini L. Karjalainen, Hannu K. Haapasalo, Ashok Aspatwar, Harlan Barker, Seppo Parkkila, Joonas A. Haapasalo

Pulse actinomycin D as first-line treatment of low-risk post-molar non-choriocarcinoma gestational trophoblastic neoplasia

• Open Access
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Lei Li, Xirun Wan, Fengzhi Feng, Tong Ren, Junjun Yang, Jun Zhao, Fang Jiang, Yang Xiang

The PDGFRβ/ERK1/2 pathway regulates CDCP1 expression in triple-negative breast cancer

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Luca Forte, Federica Turdo, Cristina Ghirelli, Piera Aiello, Patrizia Casalini, Marilena Valeria Iorio, Elvira D’Ippolito, Patrizia Gasparini, Roberto Agresti, Beatrice Belmonte, Gabriella Sozzi, Lucia Sfondrini, Elda Tagliabue, Manuela Campiglio, Francesca Bianchi

Predictive equation of metastasis in patients with malignant ovarian epithelial tumors with the Ca-125 marker

• Open Access
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Juan Fernando Sánchez Vega, Magdali del Rocío Murillo Bacilio, Adrián Santiago Vintimilla Condoy, Araceli Miroslava Palta González, José Alfredo Crespo Astudillo, Franklin Geovany Mora-Bravo

PROstate Multicentre External beam radioTHErapy Using a Stereotactic boost: the PROMETHEUS study protocol

• Open Access
• Study protocol

Matthew Richardson, Mark Sidhom, Sarah Gallagher, Mel Grand, David Pryor, Joseph Bucci, Lee Wilton, Sankar Arumugam, Sarah Keats, Jarad M. Martin

KIBRA; a novel biomarker predicting recurrence free survival of breast cancer patients receiving adjuvant therapy

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Lakmini Mudduwa, Harshini Peiris, Shania Gunasekara, Deepthika Abeysiriwardhana, Nimsha Liyanage, Suresh K. Rayala, Thusharie Liyanage

B4GALT1 expression predicts prognosis and adjuvant chemotherapy benefits in muscle-invasive bladder cancer patients

• Open Access
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Huyang Xie, Yu Zhu, Junyu Zhang, Zheng Liu, Hangcheng Fu, Yifan Cao, Gaoxiang Li, Yijun Shen, Bo Dai, Jiejie Xu, Dingwei Ye

Endogenous H2S producing enzymes are involved in apoptosis induction in clear cell renal cell carcinoma

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Jan Breza Jr, Andrea Soltysova, Sona Hudecova, Adela Penesova, Ivan Szadvari, Petr Babula, Barbora Chovancova, Lubomira Lencesova, Ondrej Pos, Jan Breza, Karol Ondrias, Olga Krizanova

Using high throughput microtissue culture to study the difference in prostate cancer cell behavior and drug response in 2D and 3D co-cultures

• Open Access
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Eman Mosaad, Karen Chambers, Kathryn Futrega, Judith Clements, Michael Robert Doran

Repurposing existing medications as cancer therapy: design and feasibility of a randomized pilot investigating propranolol administration in patients receiving hematopoietic cell transplantation

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Jennifer M. Knight, Stephanie A. Kerswill, Parameswaran Hari, Steve W. Cole, Brent R. Logan, Anita D’Souza, Nirav N. Shah, Mary M. Horowitz, Melinda R. Stolley, Erica K. Sloan, Karen E. Giles, Erin S. Costanzo, Mehdi Hamadani, Saurabh Chhabra, Binod Dhakal, J. Douglas Rizzo

Identification of genes inducing resistance to ionizing radiation in human rectal cancer cell lines: re-sensitization of radio-resistant rectal cancer cells through down regulating NDRG1

• Open Access
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Soon-Chan Kim, Young-Kyoung Shin, Ye-Ah Kim, Sang-Geun Jang, Ja-Lok Ku

IΚΚε cooperates with either MEK or non-canonical NF-kB driving growth of triple-negative breast cancer cells in different contexts

• Open Access
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Carrie D. House, Valentina Grajales, Michelle Ozaki, Elizabeth Jordan, Helmae Wubneh, Danielle C. Kimble, Jana M. James, Marianne K. Kim, Christina M. Annunziata

A Phase I clinical trial of EUS-guided intratumoral injection of the oncolytic virus, HF10 for unresectable locally advanced pancreatic cancer

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Yoshiki Hirooka, Hideki Kasuya, Takuya Ishikawa, Hiroki Kawashima, Eizaburo Ohno, Itzel B. Villalobos, Yoshinori Naoe, Toru Ichinose, Nobuto Koyama, Maki Tanaka, Yasuhiro Kodera, Hidemi Goto

High expression of forkhead box protein C2 is associated with aggressive phenotypes and poor prognosis in clinical hepatocellular carcinoma

• Open Access
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Yuki Shimoda, Yasunari Ubukata, Tadashi Handa, Takehiko Yokobori, Takayoshi Watanabe, Dolgormaa Gantumur, Kei Hagiwara, Takahiro Yamanaka, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Norifumi Harimoto, Ayaka Katayama, Toshiaki Hikino, Takaaki Sano, Kyoichi Ogata, Hiroyuki Kuwano, Ken Shirabe, Tetsunari Oyama

Erlotinib as single agent first line treatment in locally advanced or metastatic activating EGFR mutation-positive lung adenocarcinoma (CEETAC): an open-label, non-randomized, multicenter, phase IV clinical trial

• Open Access
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Zsolt Markóczy, Veronika Sárosi, Iveta Kudaba, Gabriella Gálffy, Ülkü Yilmaz Turay, Ahmet Demirkazik, Gunta Purkalne, Attila Somfay, Zsolt Pápai-Székely, Erzsébet Rásó, Gyula Ostoros

ARL2 overexpression inhibits glioma proliferation and tumorigenicity via down-regulating AXL

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Yulin Wang, Gefei Guan, Wen Cheng, Yang Jiang, Fengping Shan, Anhua Wu, Peng Cheng, Zongze Guo

GMDS knockdown impairs cell proliferation and survival in human lung adenocarcinoma

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Xing Wei, Kun Zhang, Haifeng Qin, Jinlong Zhu, Qiaoxi Qin, Yang Yu, Hong Wang

Changes in ovarian cancer survival during the 20 years before the era of targeted therapy

• Open Access
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Jung-Yun Lee, Sunghoon Kim, Young Tae Kim, Myong Cheol Lim, Boram Lee, Kyu-Won Jung, Jae Weon Kim, Sang-Yoon Park, Young-Joo Won

Knock-down of LRP/LR promotes apoptosis in early and late stage colorectal carcinoma cells via caspase activation

• Open Access
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Leila Vania, Thalia M. Rebelo, Eloise Ferreira, Stefan F. T. Weiss

Gene expression profiling of 1200 pancreatic ductal adenocarcinoma reveals novel subtypes

• Open Access
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Lan Zhao, Hongya Zhao, Hong Yan

Haemophagocytic lymphohistiocytosis occurred during induction chemotherapy in an acute monocytic leukemia patient with FLT3-ITD and DNMT3A mutations

• Open Access
• Case report

Fei Li, Xiaojie Zhang, Yunyun Wang, Ailin Yang, Zhanglin Zhang, Weiping Tang, Nan Zhong, Huidong Shi

MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT

• Open Access
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Jung-Yoon Yoo, Hee-Bum Kang, Russell R. Broaddus, John I. Risinger, Kyung-Chul Choi, Tae Hoon Kim

Comparison of the seventh and eighth editions of the UICC/AJCC staging system for nasopharyngeal carcinoma: analysis of 1317 patients treated with intensity-modulated radiotherapy at two centers

• Open Access
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Xing-Li Yang, Yan Wang, Shao-Bo Liang, Sha-Sha He, Dan-Ming Chen, Hai-Yang Chen, Li-Xia Lu, Yong Chen

Estrogen receptor α dependent regulation of estrogen related receptor β and its role in cell cycle in breast cancer

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B. Madhu Krishna, Sanjib Chaudhary, Dipti Ranjan Mishra, Sanoj K. Naik, S. Suklabaidya, A. K. Adhya, Sandip K. Mishra

Evaluation of metastatic niches in distant organs after surgical removal of tumor-bearing lymph nodes

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Jinhua Zheng, Limin Jia, Shiro Mori, Tetsuya Kodama

IFI44L is a novel tumor suppressor in human hepatocellular carcinoma affecting cancer stemness, metastasis, and drug resistance via regulating met/Src signaling pathway

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Wei-Chieh Huang, Shiao-Lin Tung, Yao-Li Chen, Po-Ming Chen, Pei-Yi Chu

Quantitative nuclear histomorphometry predicts oncotype DX risk categories for early stage ER+ breast cancer

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Jon Whitney, German Corredor, Andrew Janowczyk, Shridar Ganesan, Scott Doyle, John Tomaszewski, Michael Feldman, Hannah Gilmore, Anant Madabhushi

Aggregation of lipid rafts activates c-met and c-Src in non-small cell lung cancer cells

• Open Access
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Juan Zeng, Heying Zhang, Yonggang Tan, Cheng Sun, Yusi Liang, Jinyang Yu, Huawei Zou

PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer

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Marie-Christine Heinrich, Cosima Göbel, Martina Kluth, Christian Bernreuther, Charlotte Sauer, Cornelia Schroeder, Christina Möller-Koop, Claudia Hube-Magg, Patrick Lebok, Eike Burandt, Guido Sauter, Ronald Simon, Hartwig Huland, Markus Graefen, Hans Heinzer, Thorsten Schlomm, Asmus Heumann

ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination

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Ying Zhang, Yelong Chen, Zhaoyong Liu, Raymond Lai

The outcomes and prognostic factors in patients with osteosarcoma according to age: a Japanese nationwide study with focusing on the age differences

• Open Access
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Yusuke Tsuda, Koichi Ogura, Yusuke Shinoda, Hiroshi Kobayashi, Sakae Tanaka, Akira Kawai

Trends in lung cancer emergency presentation in England, 2006–2013: is there a pattern by general practice?

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Camille Maringe, Nora Pashayan, Francisco Javier Rubio, George Ploubidis, Stephen W. Duffy, Bernard Rachet, Rosalind Raine

Obesity as risk factor for subtypes of breast cancer: results from a prospective cohort study

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Cina J. Nattenmüller, Mark Kriegsmann, Disorn Sookthai, Renée Turzanski Fortner, Annika Steffen, Britta Walter, Theron Johnson, Jutta Kneisel, Verena Katzke, Manuela Bergmann, Hans Peter Sinn, Peter Schirmacher, Esther Herpel, Heiner Boeing, Rudolf Kaaks, Tilman Kühn

Risk of second primary Cancer among bladder Cancer patients: a population-based cohort study in Korea

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Whi-An Kwon, Jae Young Joung, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee, Young-Joo Won

Apatinib treatment for KIT- and KDR-amplified angiosarcoma: a case report

• Open Access
• Case report

Lishu Yang, Lizhu Liu, Bo Han, Wei Han, Meng Zhao

Usefulness of combined androgen blockade therapy with gonadotropin-releasing hormone antagonist for bone metastatic prostate cancer with pretreatment prostate-specific antigen level ≥ 50 ng/mL

• Open Access
• Research article

Takeshi Kashiwabara, Sayo Suda

A case of pulmonary adenocarcinoma showing rapid progression of peritoneal dissemination after immune checkpoint inhibitor therapy

• Open Access
• Case report

Taro Shinozaki, Eri Iwami, Shinnosuke Ikemura, Tatsu Matsuzaki, Takahiro Nakajima, Kazuhiko Hashimoto, Takeshi Terashima

Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway

• Open Access
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Lui Ng, Ariel K. M. Chow, Johnny H. W. Man, Thomas C. C. Yau, Timothy M. H. Wan, Deepak N. Iyer, Virginia H. T. Kwan, Ronnie T. P. Poon, Roberta W. C. Pang, Wai-Lun Law

Compressed collagen and decellularized tissue – novel components in a pipeline approach for the study of cancer metastasis

• Open Access
• Technical advance

Shirley Jean Keeton, Jean Marie Delalande, Mark Cranfield, Alan Burns, Philip Richard Dash

Reconsideration of the optimal minimum lymph node count for young colon cancer patients: a population-based study

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Xu Guan, Yuliuming Wang, Hanqing Hu, Zhixun Zhao, Zheng Jiang, Zheng Liu, Yinggang Chen, Guiyu Wang, Xishan Wang

Differences in LC3B expression and prognostic implications in oropharyngeal and oral cavity squamous cell carcinoma patients

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Kenneth Lai, Slade Matthews, James S. Wilmott, Murray C. Killingsworth, Jim L. Yong, Nicole J. Caixeiro, James Wykes, Allan Samakeh, Dion Forstner, Mark Lee, John McGuinness, Navin Niles, Angela Hong, Ardalan Ebrahimi, Cheok Soon Lee

Long-term trends in pancreatic cancer mortality in Spain (1952–2012)

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Daniel Seoane-Mato, Olivier Nuñez, Nerea Fernández-de-Larrea, Beatriz Pérez-Gómez, Marina Pollán, Gonzalo López-Abente, Nuria Aragonés

Effects of indole-3-carbinol on steroid hormone profile and tumor progression in a mice model of canine inflammatory mammarycancer

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Asunción Martín-Ruiz, Laura Peña, Alfredo González-Gil, Lucía Teresa Díez-Córdova, Sara Cáceres, Juan Carlos Illera

Solitary metastasis to a superior mediastinal lymph node after distal gastrectomy for gastric cancer: a case report

• Open Access
• Case report

Naoki Kubo, Junichi Yoshizawa, Takaomi Hanaoka

One-year mortality and Periprosthetic infection rates after Total knee Arthroplasty in Cancer patients: a population-based cohort study

• Open Access
• Research article

Feng-Chen Kao, Yao-Chun Hsu, Pang-Yu Lai, Chang-Bi Wang, Yuan-Kun Tu, Wen-Kang Chen

Perceptions of and decision making about clinical trials in adolescent and young adults with Cancer: a qualitative analysis

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Jennifer A.H. Bell, Victoria Forcina, Laura Mitchell, Seline Tam, Kate Wang, Abha A. Gupta, Jeremy Lewin

Itraconazole treatment of primary malignant melanoma of the vagina evaluated using positron emission tomography and tissue cDNA microarray: a case report

• Open Access
• Melanom
• Case report

Kayo Inoue, Hiroshi Tsubamoto, Roze Isono-Nakata, Kazuko Sakata, Nami Nakagomi

MiR-199a-3p affects the multi-chemoresistance of osteosarcoma through targeting AK4

• Open Access
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Wang Lei, Chen Yan, Jiang Ya, Dai Yong, Bian Yujun, Liu Kai

Survival after the diagnosis of breast or colorectal cancer in the GAZA Strip from 2005 to 2014

• Open Access
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Chiara Panato, Khaled Abusamaan, Ettore Bidoli, Mokhtar Hamdi-Cherif, Daniela Pierannunzio, Stefano Ferretti, Mahmoud Daher, Fouad Elissawi, Diego Serraino

Hepatic arterial infusion chemotherapy followed by sorafenib in patients with advanced hepatocellular carcinoma (HICS 55): an open label, non-comparative, phase II trial

• Open Access
• Research article

Masahiro Hatooka, Tomokazu Kawaoka, Hiroshi Aikata, Yuki Inagaki, Kei Morio, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Kazuo Awai, Keiichi Masaki, Koji Waki, Hirotaka Kohno, Hiroshi Kohno, Takashi Moriya, Yuko Nagaoki, Toru Tamura, Hajime Amano, Yoshio Katamura, Kazuaki Chayama

Pregnancy-associated breast cancer in rural Rwanda: the experience of the Butaro Cancer Center of Excellence

• Open Access
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Jean Marie Vianney Dusengimana, Vedaste Hategekimana, Ryan Borg, Bethany Hedt-Gauthier, Neil Gupta, Susan Troyan, Lawrence N. Shulman, Ignace Nzayisenga, Temidayo Fadelu, Tharcisse Mpunga, Lydia E. Pace

Body mass index and lung cancer risk in never smokers: a meta-analysis

• Open Access
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Hongjun Zhu, Shuanglin Zhang

Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment

• Open Access
• Research article

Chrysi Xintaropoulou, Carol Ward, Alan Wise, Suzanna Queckborner, Arran Turnbull, Caroline O. Michie, Alistair R. W. Williams, Tzyvia Rye, Charlie Gourley, Simon P. Langdon

A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women

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Nicole C. Deziel, Huangdi Yi, Heather M. Stapleton, Huang Huang, Nan Zhao, Yawei Zhang

An implementation of normal distribution based segmentation and entropy controlled features selection for skin lesion detection and classification

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M. Attique Khan, Tallha Akram, Muhammad Sharif, Aamir Shahzad, Khursheed Aurangzeb, Musaed Alhussein, Syed Irtaza Haider, Abdualziz Altamrah

Projected cervical Cancer incidence in Swaziland using three methods and local survey estimates

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Themba G. Ginindza, Benn Sartorius

Deep sequencing of human papillomavirus positive loco-regionally advanced oropharyngeal squamous cell carcinomas reveals novel mutational signature

• Open Access
• Research article

Christian Grønhøj, David H. Jensen, Tina Agander, Katalin Kiss, Estrid Høgdall, Lena Specht, Frederik Otzen Bagger, Finn Cilius Nielsen, Christian von Buchwald

RETRACTED ARTICLE: p300 promotes proliferation, migration, and invasion via inducing epithelial-mesenchymal transition in non-small cell lung cancer cells

• Open Access
• Research article

Xue Hou, Run Gong, Jianhua Zhan, Ting Zhou, Yuxiang Ma, Yuanyuan Zhao, Yaxiong Zhang, Gang Chen, Zhonghan Zhang, Shuxiang Ma, Xi Chen, Fangfang Gao, Shaodong Hong, Fan Luo, Wenfeng Fang, Yunpeng Yang, Yan Huang, Likun Chen, Haoxian Yang, Li Zhang

Decreased expression of SRY-box containing gene 30 is related to malignant phenotypes of human bladder cancer and correlates with poor prognosis

• Open Access
• Research article

Yang Liu, Han Wang, Jianhua Zhong, Chenglong Wu, Gang Yang, Yuantang Zhong, Jinghua Zhang, Aifa Tang

Comparison of hepatic resection and transarterial chemoembolization for UICC stage T3 hepatocellular carcinoma: a propensity score matching study

• Open Access
• Research article

Chong Zhong, Yong-Fa Zhang, Jun-Hai Huang, Cheng-Ming Xiong, Zi-Yu Wang, Qing-Lian Chen, Rong-Ping Guo

Efficacy and safety profile of drug-eluting beads transarterial chemoembolization by CalliSpheres® beads in Chinese hepatocellular carcinoma patients

• Open Access
• Research article

Guan-Hui Zhou, Jun Han, Jun-Hui Sun, Yue-Lin Zhang, Tan-Yang Zhou, Chun-Hui Nie, Tong-Yin Zhu, Sheng-Qun Chen, Bao-Quan Wang, Zi-Niu Yu, Hong-Liang Wang, Li-Ming Chen, Wei-Lin Wang, Shu-Sen Zheng

A patient with plasmablastic lymphoma achieving long-term complete remission after thalidomide-dexamethasone induction and double autologous stem cell transplantation: a case report

• Open Access
• Non-Hodgkin-Lymphome
• Case report

Alessandro Broccoli, Laura Nanni, Vittorio Stefoni, Claudio Agostinelli, Lisa Argnani, Michele Cavo, Pier Luigi Zinzani

A first-in-human study investigating biodistribution, safety and recommended dose of a new radiolabeled MAb targeting FZD10 in metastatic synovial sarcoma patients

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• Research article

Anne-Laure Giraudet, Philippe Alexandre Cassier, Chicaco Iwao-Fukukawa, Gwenaelle Garin, Jean-Noël Badel, David Kryza, Sylvie Chabaud, Laurence Gilles-Afchain, Gilles Clapisson, Claude Desuzinges, David Sarrut, Adrien Halty, Antoine Italiano, Masaharu Mori, Takuya Tsunoda, Toyomasa Katagiri, Yusuke Nakamura, Laurent Alberti, Claire Cropet, Simon Baconnier, Sandrine Berge-Montamat, David Pérol, Jean-Yves Blay

Hereditary breast and ovarian cancer in Andalusian families: a genetic population study

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Bella Pajares, Javier Porta, Jose María Porta, Cristina Fernández-de Sousa, Ignacio Moreno, Daniel Porta, Gema Durán, Tamara Vega, Inmaculada Ortiz, Carolina Muriel, Emilio Alba, Antonia Márquez

Dynamic Hyaluronan drives liver endothelial cells towards angiogenesis

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Sampa Ghose, Subhrajit Biswas, Kasturi Datta, Rakesh K. Tyagi

Effect of perioperative blood transfusion on prognosis of patients with gastric cancer: a retrospective analysis of a single center database

• Open Access
• Research article

Xiaowen Liu, Mingze Ma, Hua Huang, Yanong Wang

Detection of intracellular IgD using flow cytometry could be a novel and supplementary method to diagnose IgD multiple myeloma

• Open Access
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Wei Wang, Chun-Xia Zhang, Zhen-Ling Li, Ming Gong, Yi-Gai Ma

Observational study on the prognostic value of testosterone and adiposity in postmenopausal estrogen receptor positive breast cancer patients

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• Research article

Elisabetta Venturelli, Annalisa Orenti, Aline S. C. Fabricio, Giulia Garrone, Roberto Agresti, Biagio Paolini, Chiara Bonini, Massimo Gion, Franco Berrino, Christine Desmedt, Danila Coradini, Elia Biganzoli

PD-L1 assessment in pediatric rhabdomyosarcoma: a pilot study

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Giulia Bertolini, Luca Bergamaschi, Andrea Ferrari, Salvatore L. Renne, Paola Collini, Cecilia Gardelli, Marta Barisella, Giovanni Centonze, Stefano Chiaravalli, Cinzia Paolino, Massimo Milione, Maura Massimino, Michela Casanova, Patrizia Gasparini

Increasing incidence of central nervous system (CNS) tumors (2000–2012): findings from a population based registry in Gironde (France)

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Camille Pouchieu, Anne Gruber, Emilie Berteaud, Patrice Ménégon, Pascal Monteil, Aymeri Huchet, Jean-Rodolphe Vignes, Anne Vital, Hugues Loiseau, Isabelle Baldi

Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes

• Open Access
• Research article

Trygve Lofterød, Elin S. Mortensen, Hawa Nalwoga, Tom Wilsgaard, Hanne Frydenberg, Terje Risberg, Anne Elise Eggen, Anne McTiernan, Sura Aziz, Erik A. Wist, Andreas Stensvold, Jon B. Reitan, Lars A. Akslen, Inger Thune

TOPical Imiquimod treatment of residual or recurrent cervical intraepithelial neoplasia (TOPIC-2 trial): a study protocol for a randomized controlled trial

• Open Access
• Study protocol

A. J. M. van de Sande, M. M. Koeneman, C. G. Gerestein, A. J. Kruse, F. J. van Kemenade, H. J. van Beekhuizen

ALDH1A inhibition sensitizes colon cancer cells to chemotherapy

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Z. Kozovska, A. Patsalias, V. Bajzik, E. Durinikova, L. Demkova, S. Jargasova, B. Smolkova, J. Plava, L. Kucerova, M. Matuskova

Expression of the glucagon-like peptide-1 receptor and its role in regulating autophagy in endometrial cancer

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Ranka Kanda, Haruko Hiraike, Osamu Wada-Hiraike, Takayuki Ichinose, Kazunori Nagasaka, Yuko Sasajima, Eiji Ryo, Tomoyuki Fujii, Yutaka Osuga, Takuya Ayabe

A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk

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Qin Xiao, Lianzhou Chen, Haiqing Luo, Hongmei Li, Qingming Kong, Fei Jiao, Shifeng Pang, Ming Zhang, Feifei Lan, Wenguo Fan, Hui Luo, Tao Tao, Xiao Zhu

MALBAC-based chromosomal imbalance analysis: a novel technique enabling effective non-invasive diagnosis and monitoring of bladder cancer

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Hao Liu, Wang He, Bo Wang, Kewei Xu, Jinli Han, Junjiong Zheng, Jun Ren, Lin Shao, Shiping Bo, Sijia Lu, Tianxin Lin, Jian Huang

Long non-coding RNA RUNXOR accelerates MDSC-mediated immunosuppression in lung cancer

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Xinyu Tian, Jie Ma, Ting Wang, Jie Tian, Yu Zheng, Rongrong Peng, Yungang Wang, Yue Zhang, Lingxiang Mao, Huaxi Xu, Shengjun Wang

Golgi phosphoprotein 3 (GOLPH3) promotes hepatocellular carcinoma progression by activating mTOR signaling pathway

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Hongying Liu, Xieqi Wang, Bing Feng, Lipeng Tang, Weiping Li, Xirun Zheng, Ying Liu, Yan Peng, Guangjuan Zheng, Qinglian He

Low expression of RECQL is associated with poor prognosis in Chinese breast cancer patients

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Huiying Xu, Ye Xu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB

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David M. Cordas dos Santos, Juliane Eilers, Alfonso Sosa Vizcaino, Elena Orlova, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Kathleen Börner, Dirk Grimm, Martina U. Muckenthaler, Andreas E. Kulozik, Joachim B. Kunz

Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas

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Mari Valkonen, Hannu Haapasalo, Kirsi Rilla, Kristiina Tyynelä-Korhonen, Ylermi Soini, Sanna Pasonen-Seppänen

Gallbladder cancer: review of a rare orphan gastrointestinal cancer with a focus on populations of New Mexico

• Open Access
• Review

Jacklyn M. Nemunaitis, Ursa Brown-Glabeman, Heloisa Soares, Jessica Belmonte, Ben Liem, Itzhak Nir, Victor Phuoc, Rama R. Gullapalli

Effects of local anesthetics on breast cancer cell viability and migration

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• Research article

Ru Li, Chunyun Xiao, Hengrui Liu, Yujie Huang, James P. Dilger, Jun Lin

Treatment in the STAMPEDE era for castrate resistant prostate cancer in the UK: ongoing challenges and underappreciated clinical problems

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Rosa U. Greasley, Rebecca Turner, Karen Collins, Janet Brown, Liam Bourke, Derek J. Rosario

Which approach is preferred in left hepatocellular carcinoma? Laparoscopic versus open hepatectomy using propensity score matching

• Open Access
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Jong Man Kim, Choon Hyuck David Kwon, Heejin Yoo, Kyeung-Sik Kim, Jisoo Lee, Kyunga Kim, Gyu-Seong Choi, Jae-Won Joh

PD-1 blockade in combination with zoledronic acid to enhance the antitumor efficacy in the breast cancer mouse model

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Yuan Li, Yang Du, Ting Sun, Huadan Xue, Zhengyu Jin, Jie Tian

TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association

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• Research article

Justin Zonneville, Alfiya Safina, Alexander M. Truskinovsky, Carlos L. Arteaga, Andrei V. Bakin

Induction therapy with paclitaxel and bevacizumab followed by switch maintenance therapy with eribulin in Japanese patients with HER2-negative metastatic breast cancer: a multicenter, collaborative, open-label, phase II clinical study for the SBCCSG 35 investigators

• Open Access
• Research article

Kenichi Inoue, Jun Ninomiya, Tsuyoshi Saito, Kei Kimizuka, Masafumi Kurosumi

Treatment outcomes in metastatic and localized high-grade salivary gland cancer: high chance of cure with surgery and post-operative radiation in T1–2 N0 high-grade salivary gland cancer

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• Research article

Jeon Yeob Jang, Nayeon Choi, Young-Hyeh Ko, Man Ki Chung, Young-Ik Son, Chung-Hwan Baek, Kwan-Hyuck Baek, Han-Sin Jeong

WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage

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Beth K. Neilsen, Binita Chakraborty, Jamie L. McCall, Danielle E. Frodyma, Richard L. Sleightholm, Kurt W. Fisher, Robert E. Lewis

HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells

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Hannah Harrison, Henry J. Pegg, Jamie Thompson, Christian Bates, Paul Shore

Differential expression of ABCB5 in BRAF inhibitor-resistant melanoma cell lines

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Jingjing Xiao, Michael E. Egger, Kelly M. McMasters, Hongying Hao

Droplet digital PCR-based circulating microRNA detection serve as a promising diagnostic method for gastric cancer

• Open Access
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Gaoping Zhao, Tao Jiang, Yanzhuo Liu, Guoli Huai, Chunbin Lan, Guiquan Li, Guiqing Jia, Kang Wang, Maozhu Yang

Efficacy of a hypnosis-based intervention to improve well-being during cancer: a comparison between prostate and breast cancer patients

• Open Access
• Research article

C. Grégoire, H. Nicolas, I. Bragard, F. Delevallez, I. Merckaert, D. Razavi, D. Waltregny, M.-E. Faymonville, A. Vanhaudenhuyse

Chloroquine reduces hypercoagulability in pancreatic cancer through inhibition of neutrophil extracellular traps

• Open Access
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Brian A. Boone, Pranav Murthy, Jennifer Miller-Ocuin, W. Reed Doerfler, Jarrod T. Ellis, Xiaoyan Liang, Mark A. Ross, Callen T. Wallace, Jason L. Sperry, Michael T. Lotze, Matthew D. Neal, Herbert J. Zeh III

Serum MMP-8 and TIMP-1 predict prognosis in colorectal cancer

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Camilla Böckelman, Ines Beilmann-Lehtonen, Tuomas Kaprio, Selja Koskensalo, Taina Tervahartiala, Harri Mustonen, Ulf-Håkan Stenman, Timo Sorsa, Caj Haglund

Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

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Yuko Murakami, Kazuo Sugiyama, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Keisuke Ojiro, Po-sung Chu, Nobuhito Taniki, Yoshimasa Saito, Toshiaki Teratani, Yuzo Koda, Takahiro Suzuki, Kyoko Saito, Masayoshi Fukasawa, Masanori Ikeda, Nobuyuki Kato, Takanori Kanai, Hidetsugu Saito

MicroRNA-29b-2-5p inhibits cell proliferation by directly targeting Cbl-b in pancreatic ductal adenocarcinoma

• Open Access
• Research article

Ce Li, Qian Dong, Xiaofang Che, Ling Xu, Zhi Li, Yibo Fan, Kezuo Hou, Shuo Wang, Jinglei Qu, Lu Xu, Ti Wen, Xianghong Yang, Xiujuan Qu, Yunpeng Liu

Gene expression profile and cancer-associated pathways linked to progesterone receptor isoform a (PRA) predominance in transgenic mouse mammary glands

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• Research article

María José Carlini, María Sol Recouvreux, Marina Simian, Maria Aparecida Nagai

The effect of low insurance reimbursement on quality of care for non-small cell lung cancer in China: a comprehensive study covering diagnosis, treatment, and outcomes

• Open Access
• Research article

Xi Li, Qi Zhou, Xinyu Wang, Shaofei Su, Meiqi Zhang, Hao Jiang, Jiaying Wang, Meina Liu

High expression of the p53 isoform γ is associated with reduced progression-free survival in uterine serous carcinoma

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• Research article

Katharina Bischof, Stian Knappskog, Ingunn Stefansson, Emmet Martin McCormack, Jone Trovik, Henrica Maria Johanna Werner, Kathrine Woie, Bjorn Tore Gjertsen, Line Bjorge

Replacing sedentary time with physical activity or sleep: effects on cancer-related cognitive impairment in breast cancer survivors

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• Research article

Diane K. Ehlers, Jason Fanning, Elizabeth A. Salerno, Susan Aguiñaga, Josh Cosman, Joan Severson, Arthur F. Kramer, Edward McAuley

Oral cancer incidence in Shanghai ---- a temporal trend analysis from 2003 to 2012

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Jin-Ye Fu, Chun-Xiao Wu, Chen-Ping Zhang, Jing Gao, Jian-Feng Luo, Shu-Kun Shen, Ying Zheng, Zhi-Yuan Zhang

Heparan sulfate proteoglycans undergo differential expression alterations in left sided colorectal cancer, depending on their metastatic character

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Ainara Crespo, Olivia García-Suárez, Iván Fernández-Vega, María Pilar Solis-Hernandez, Beatriz García, Sonia Castañón, Luis M. Quirós

Trends in pancreatic adenocarcinoma incidence and mortality in the United States in the last four decades; a SEER-based study

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Anas M. Saad, Tarek Turk, Muneer J. Al-Husseini, Omar Abdel-Rahman

Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways

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Michelle van Geldermalsen, Lake-Ee Quek, Nigel Turner, Natasha Freidman, Angel Pang, Yi Fang Guan, James R. Krycer, Renae Ryan, Qian Wang, Jeff Holst

Estrogen-related receptors alpha, beta and gamma expression and function is associated with transcriptional repressor EZH2 in breast carcinoma

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• Research article

Kanchan Kumari, Amit K. Adhya, Arabinda Kumar Rath, P. B. Reddy, Sandip K. Mishra

Loss of expression and prognosis value of alpha-internexin in gastroenteropancreatic neuroendocrine neoplasm

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• Research article

Yuhong Wang, Yuanjia Chen, Xiaoxing Li, Wanming Hu, Yu Zhang, Luohai Chen, Minhu Chen, Jie Chen

An inflammation-related nomogram for predicting the survival of patients with non-small cell lung cancer after pulmonary lobectomy

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• Research article

Ying Wang, Xiao Qu, Ngar-Woon Kam, Kai Wang, Hongchang Shen, Qi Liu, Jiajun Du

Nanoliposomal irinotecan with fluorouracil for the treatment of advanced pancreatic cancer, a single institution experience

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• Research article

Danielle C. Glassman, Randze L. Palmaira, Christina M. Covington, Avni M. Desai, Geoffrey Y. Ku, Jia Li, James J. Harding, Anna M. Varghese, Eileen M. O’Reilly, Kenneth H. Yu

Estimates and predictors of health care costs of esophageal adenocarcinoma: a population-based cohort study

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Hla-Hla Thein, Nathaniel Jembere, Kednapa Thavorn, Kelvin K. W. Chan, Peter C. Coyte, Claire de Oliveira, Chin Hur, Craig C. Earle

Gene promoter and exon DNA methylation changes in colon cancer development – mRNA expression and tumor mutation alterations

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Béla Molnár, Orsolya Galamb, Bálint Péterfia, Barnabás Wichmann, István Csabai, András Bodor, Alexandra Kalmár, Krisztina Andrea Szigeti, Barbara Kinga Barták, Zsófia Brigitta Nagy, Gábor Valcz, Árpád V. Patai, Péter Igaz, Zsolt Tulassay

MicroRNAs as markers of progression in cervical cancer: a systematic review

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Barbara Pardini, Daniela De Maria, Antonio Francavilla, Cornelia Di Gaetano, Guglielmo Ronco, Alessio Naccarati

Pancreatic cancer as a sentinel for hereditary cancer predisposition

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Erin L. Young, Bryony A. Thompson, Deborah W. Neklason, Matthew A. Firpo, Theresa Werner, Russell Bell, Justin Berger, Alison Fraser, Amanda Gammon, Cathryn Koptiuch, Wendy K. Kohlmann, Leigh Neumayer, David E. Goldgar, Sean J. Mulvihill, Lisa A. Cannon-Albright, Sean V. Tavtigian

Long-term efficacy of lenvatinib for recurrent papillary thyroid carcinoma after multimodal treatment and management of complications: a case report

• Open Access
• Schilddrüsenkarzinome
• Case report

Masayuki Tori, Toshirou Shimo

Preoperative controlling nutritional status (CONUT) score as a predictor of long-term outcome after curative resection followed by adjuvant chemotherapy in stage II-III gastric Cancer

• Open Access
• Research article

Xuechao Liu, Deyao Zhang, Enzi Lin, Yongming Chen, Wei Li, Yingbo Chen, Xiaowei Sun, Zhiwei Zhou

Comprehensive transcriptomic analysis of heat shock proteins in the molecular subtypes of human breast cancer

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• Research article

Felipe C. M. Zoppino, Martin E. Guerrero-Gimenez, Gisela N. Castro, Daniel R. Ciocca

Phase II trial of eribulin mesylate as a first- or second-line treatment for locally advanced or metastatic breast cancer: a multicenter, single-arm trial

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Tetsu Hayashida, Hiromitsu Jinno, Katsuaki Mori, Hiroki Sato, Akira Matsui, Takashi Sakurai, Hiroaki Hattori, Shin Takayama, Masahiro Wada, Maiko Takahashi, Hirohito Seki, Tomoko Seki, Aiko Nagayama, Akiko Matsumoto, Yuko Kitagawa

Efficacy after preoperative capecitabine and oxaliplatin (XELOX) versus docetaxel, oxaliplatin and S1 (DOS) in patients with locally advanced gastric adenocarcinoma: a propensity score matching analysis

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Yan Wang, Xi Cheng, Yue-hong Cui, Jun Hou, Yuan Ji, Yi-hong Sun, Zhen-bin Shen, Feng-lin Liu, Tian-shu Liu

FOXA1 and AR in invasive breast cancer: new findings on their co-expression and impact on prognosis in ER-positive patients

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Nelson Rangel, Nicoletta Fortunati, Simona Osella-Abate, Laura Annaratone, Claudio Isella, Maria Graziella Catalano, Letizia Rinella, Jasna Metovic, Renzo Boldorini, Davide Balmativola, Pietro Ferrando, Francesca Marano, Paola Cassoni, Anna Sapino, Isabella Castellano

Possible roles of genetic variations in chemotherapy related cardiotoxicity in pediatric acute lymphoblastic leukemia and osteosarcoma

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Judit C. Sági, Bálint Egyed, Andrea Kelemen, Nóra Kutszegi, Márta Hegyi, András Gézsi, Martina Ayaka Herlitschke, Andrea Rzepiel, Lili E. Fodor, Gábor Ottóffy, Gábor T. Kovács, Dániel J. Erdélyi, Csaba Szalai, Ágnes F. Semsei

Ineffective anti PD-1 therapy after BRAF inhibitor failure in advanced melanoma

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M. Amini-Adle, N. Khanafer, M. Le-Bouar, G. Duru, S. Dalle, L. Thomas

Improvements to the gastric cancer tumor-node-metastasis staging system based on computer-aided unsupervised clustering

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• Research article

Zhiqiong Wang, Mo Li, Zhen Xu, Yanlin Jiang, Huizi Gu, Ying Yu, Haitao Zhu, Hao Zhang, Ping Lu, Junchang Xin, Hong Xu, Caigang Liu

Effect of early and intensive nutrition care, delivered via telephone or mobile application, on quality of life in people with upper gastrointestinal cancer: study protocol of a randomised controlled trial

• Open Access
• Study protocol

Lauren Hanna, Catherine E. Huggins, Kate Furness, Mary Anne Silvers, June Savva, Helena Frawley, Daniel Croagh, Paul Cashin, Liang Low, Judith Bauer, Helen Truby, Terrence Haines

Kaposi’s sarcoma of the conjunctiva and the eyelid leads to the diagnosis of human immunodeficiency virus infection – a case report

• Open Access
• Case report

Filipe Sousa Neves, Joana Braga, João Cardoso da Costa, Joaquim Sequeira, Sandra Prazeres

Mutant p53 gain of function induces HER2 over-expression in cancer cells

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• Research article

A. A. Román-Rosales, E. García-Villa, L. A. Herrera, P. Gariglio, J. Díaz-Chávez

Nm23-H1 is involved in the repair of ionizing radiation-induced DNA double-strand breaks in the A549 lung cancer cell line

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Ya Sheng, Mingfang Xu, Chongyi Li, Yanli Xiong, Yi Yang, Xunjie Kuang, Dong Wang, Xueqin Yang

Aberrant Promoter Methylation of YAP Gene and its Subsequent Downregulation in Indian Breast Cancer Patients

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Sumayya Abdul Sattar Real, Farah Parveen, Asad Ur Rehman, Mohammad Aasif Khan, Sankaravamasam Venkata Suryanarayan Deo, Nootan Kumar Shukla, Syed Akhtar Husain

Cancer incidence and mortality rates and trends in Trinidad and Tobago

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Wayne A. Warner, Tammy Y. Lee, Kimberly Badal, Tanisha M. Williams, Smriti Bajracharya, Vasavi Sundaram, Nigel A. Bascombe, Ravi Maharaj, Marjorie Lamont-Greene, Allana Roach, Melissa Bondy, Matthew J. Ellis, Timothy R. Rebbeck, Simeon Slovacek, Jingqin Luo, Adetunji T. Toriola, Adana A. M. Llanos

Outcome of inflammatory breast cancer in Moroccan patients: clinical, molecular and pathological characteristics of 219 cases from the National Oncology Institute (INO)

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Meriem Slaoui, Abdou Azaque Zoure, Fatima Zahra Mouh, Youssef Bensouda, Mohammed El Mzibri, Youssef Bakri, Mariam Amrani

3-O-Acetyloleanolic acid inhibits VEGF-A-induced lymphangiogenesis and lymph node metastasis in an oral cancer sentinel lymph node animal model

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Jeon Hwang-Bo, Mun Gyeong Bae, Jong-Hwa Park, In Sik Chung

MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells

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Yi Na Yoon, Min Ho Choe, Kwan-Young Jung, Sang-Gu Hwang, Jeong Su Oh, Jae-Sung Kim

Trans-arterial radioembolization for intermediate-advanced hepatocellular carcinoma: a budget impact analysis

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• Research article

Carla Rognoni, Oriana Ciani, Silvia Sommariva, Irene Bargellini, Sherrie Bhoori, Roberto Cioni, Antonio Facciorusso, Rita Golfieri, Annagiulia Gramenzi, Vincenzo Mazzaferro, Cristina Mosconi, Francesca Ponziani, Rodolfo Sacco, Franco Trevisani, Rosanna Tarricone

Bulk tumour cell migration in lung carcinomas might be more common than epithelial-mesenchymal transition and be differently regulated

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Martin Zacharias, Luka Brcic, Sylvia Eidenhammer, Helmut Popper

Docetaxel facilitates lymphatic-tumor crosstalk to promote lymphangiogenesis and cancer progression

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• Research article

Alexandra R. Harris, Matthew J. Perez, Jennifer M. Munson

Validation of a high performance functional assay for individual radiosensitivity in pediatric oncology: a prospective cohort study (ARPEGE)

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• Study protocol

Valérie Bernier-chastagner, Liza Hettal, Véronique Gillon, Laurinda Fernandes, Cécile Huin-schohn, Marion Vazel, Priscillia Tosti, Julia Salleron, Aurélie François, Elise Cérimèle, Sandrine Perreira, Didier Peiffert, Pascal Chastagner, Guillaume Vogin

Study protocol of the RaPS study: novel risk adapted prevention strategies for people with a family history of colorectal cancer

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• Study protocol

Kaja Tikk, Korbinian Weigl, Michael Hoffmeister, Svitlana Igel, Matthias Schwab, Jochen Hampe, Stefanie J. Klug, Ulrich Mansmann, Frank Kolligs, Hermann Brenner

Differential expression of hsa-miR-221, hsa-miR-21, hsa-miR-135b, and hsa-miR-29c suggests a field effect in oral cancer

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• Research article

Camile B. Lopes, Leandro L. Magalhães, Carolina R. Teófilo, Ana Paula N. N. Alves, Raquel C. Montenegro, Massimo Negrini, Ândrea Ribeiro-dos-Santos

LIM and SH3 protein 1 regulates cell growth and chemosensitivity of human glioblastoma via the PI3K/AKT pathway

• Open Access
• Research article

Chuanhong Zhong, Yitian Chen, Bei Tao, Lilei Peng, Tangming Peng, Xiaobo Yang, Xiangguo Xia, Ligang Chen

Targeting HOX-PBX interactions causes death in oral potentially malignant and squamous carcinoma cells but not normal oral keratinocytes

• Open Access
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Christopher Platais, Raghu Radhakrishnan, Sven Niklander Ebensperger, Richard Morgan, Daniel W. Lambert, Keith D. Hunter

MAFb protein confers intrinsic resistance to proteasome inhibitors in multiple myeloma

• Open Access
• Research article

Ya-Wei Qiang, Shiqiao Ye, Yuhua Huang, Yu Chen, Frits Van Rhee, Joshua Epstein, Brian A. Walker, Gareth J. Morgan, Faith E. Davies

Thoracic injection of low-dose interleukin-2 as an adjuvant therapy improves the control of the malignant pleural effusions: a systematic review and meta-analysis base on Chinese patients

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Liping Han, Qiufang Jiang, Wei Yao, Tian Fu, Qingdi Zeng

Correlation between circulating tumour DNA and metabolic tumour burden in metastatic melanoma patients

• Open Access
• Research article

Ashleigh C. McEvoy, Lydia Warburton, Zeyad Al-Ogaili, Liesl Celliers, Leslie Calapre, Michelle R. Pereira, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Melanie Ziman, Elin S. Gray

Improving medication adherence with adjuvant aromatase inhibitor in women with breast cancer: study protocol of a randomised controlled trial to evaluate the effect of short message service (SMS) reminder

• Open Access
• Study protocol

Yunxin He, Eng Hooi Tan, Andrea Li Ann Wong, Chuan Chien Tan, Patrick Wong, Soo Chin Lee, Bee Choo Tai

Characterization of primary normal and malignant breast cancer cell and their response to chemotherapy and immunostimulatory agents

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• Research article

Anna A. Nushtaeva, Grigory A. Stepanov, Dmitry V. Semenov, Evgeny S. Juravlev, Evgenia A. Balahonova, Alexey V. Gerasimov, Sergey V. Sidorov, Eugeniy I. Savelyev, Elena V. Kuligina, Vladimir A. Richter, Olga A. Koval

Clinical response and pharmacokinetics of bendamustine as a component of salvage R-B(O)AD therapy for the treatment of primary central nervous system lymphoma (PCNSL)

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Therasa Kim, He Yun Choi, Hyun-Seo Lee, Sung-Hoon Jung, Jae-Sook Ahn, Hyeoung-Joon Kim, Je-Jung Lee, Hee-Doo Yoo, Deok-Hwan Yang

Interleukin 8 is a biomarker of telomerase inhibition in cancer cells

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Peter Solomon, Yuying Dong, Shaillay Dogra, Romi Gupta

BET Bromodomain inhibition promotes De-repression of TXNIP and activation of ASK1-MAPK pathway in acute myeloid leukemia

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Yafeng Zhou, Jianbiao Zhou, Xiao Lu, Tuan-Zea Tan, Wee-Joo Chng

Understanding adjuvant endocrine therapy persistence in breast Cancer survivors

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Leah K. Lambert, Lynda G. Balneaves, A. Fuchsia Howard, Stephen K. Chia, Carolyn C. Gotay

Quality indicators of clinical cancer care for prostate cancer: a population-based study in southern Switzerland

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Laura Ortelli, Alessandra Spitale, Luca Mazzucchelli, Andrea Bordoni

A pilot study to profile salivary angiogenic factors to detect head and neck cancers

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L. van der Merwe, Y. Wan, H. J. Cheong, C. Perry, C. Punyadeera

Distribution patterns of foot and ankle tumors: a university tumor institute experience

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Andreas Toepfer, Norbert Harrasser, Maximiliane Recker, Ulrich Lenze, Florian Pohlig, Ludger Gerdesmeyer, Rüdiger von Eisenhart-Rothe

Prognostic and clinicopathological significance of MLKL expression in cancer patients: a meta-analysis

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Binwu Hu, Deyao Shi, Xiao Lv, Songfeng Chen, Qin Huang, Mao Xie, Zengwu Shao

Diagnostic value of intraoperative ultrasonography in assessing thoracic recurrent laryngeal nerve lymph nodes in patients with esophageal cancer

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Jianwei Wang, Min Liu, Jingxian Shen, Haichao Ouyang, Xiuying Xie, Ting Lin, Anhua Li, Hong Yang

Chromoanasynthesis is a common mechanism that leads to ERBB2 amplifications in a cohort of early stage HER2+ breast cancer samples

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George Vasmatzis, Xue Wang, James B. Smadbeck, Stephen J. Murphy, Katherine B. Geiersbach, Sarah H. Johnson, Athanasios G. Gaitatzes, Yan W. Asmann, Farhad Kosari, Mitesh J. Borad, Daniel J. Serie, Sarah A. McLaughlin, Jennifer M. Kachergus, Brian M. Necela, E. Aubrey Thompson

Levels and prognostic impact of circulating markers of inflammation, endothelial activation and extracellular matrix remodelling in patients with lung cancer and chronic obstructive pulmonary disease

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Janna Berg, Ann Rita Halvorsen, May-Bente Bengtson, Kristin A. Taskén, Gunhild M. Mælandsmo, Arne Yndestad, Bente Halvorsen, Odd Terje Brustugun, Pål Aukrust, Thor Ueland, Åslaug Helland

The detrimental effects of radiotherapy interruption on local control after concurrent chemoradiotherapy for advanced T-stage nasopharyngeal carcinoma: an observational, prospective analysis

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Ji-Jin Yao, Ya-Nan Jin, Si-Yang Wang, Fan Zhang, Guan-Qun Zhou, Wang-Jian Zhang, Zhi-Bin, Cheng, Jun Ma, Zhen-Yu Qi, Ying Sun

CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors

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Cláudia S. Marques, Ana Rita Santos, Andreia Gameiro, Jorge Correia, Fernando Ferreira

AKT isoform-specific expression and activation across cancer lineages

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Jue Wang, Wei Zhao, Huifang Guo, Yong Fang, Sarah Elizabeth Stockman, Shanshan Bai, Patrick Kwok-Shing Ng, Yang Li, Qinghua Yu, Yiling Lu, Kang Jin Jeong, Xiaohua Chen, Meng Gao, Jiyong Liang, Wentao Li, Xingsong Tian, Eric Jonasch, Gordon B. Mills, Zhiyong Ding

Correction to: the impact of pharmacokinetic gene profiles across human cancers

• Open Access
• Correction

Michael T. Zimmermann, Terry M. Therneau, Jean-Pierre A. Kocher

The Promoting Activity in Cancer Survivors (PACES) trial: a multiphase optimization of strategy approach to increasing physical activity in breast cancer survivors

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• Study protocol

Chad D. Rethorst, Heidi A. Hamann, Thomas J. Carmody, Kendall J. Sharp, Keith E. Argenbright, Barbara B. Haley, Celette Sugg Skinner, Madhukar H. Trivedi

Women’s knowledge and attitudes related to cervical cancer and cervical cancer screening in Isiolo and Tharaka Nithi counties, Kenya: a cross-sectional study

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Murithi Gatumo, Susan Gacheri, Abdul-Rauf Sayed, Andrew Scheibe

Recombinant oncolytic Newcastle disease virus displays antitumor activities in anaplastic thyroid cancer cells

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Ke Jiang, Cuiping Song, Lingkai Kong, Lulu Hu, Guibin Lin, Tian Ye, Gang Yao, Yupeng Wang, Haibo Chen, Wei Cheng, Martin P. Barr, Quentin Liu, Guirong Zhang, Chan Ding, Songshu Meng

A multicenter phase 4 geriatric assessment directed trial to evaluate gemcitabine +/− nab-paclitaxel in elderly pancreatic cancer patients (GrantPax)

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• Study protocol

Johannes Betge, Jing Chi-Kern, Nadine Schulte, Sebastian Belle, Tobias Gutting, Elke Burgermeister, Ralf Jesenofsky, Martin Maenz, Ulrich Wedding, Matthias P. Ebert, Nicolai Haertel

Study protocol of the CORRECT multicenter trial: the efficacy of blended cognitive behavioral therapy for reducing psychological distress in colorectal cancer survivors

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• Study protocol

L. Leermakers, S. Döking, B. Thewes, A. M. J. Braamse, M. F. M. Gielissen, J. H. W. de Wilt, E. H. Collette, J. Dekker, J. B. Prins

Correction to: Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer

• Open Access
• Correction

Jessica A. Gibbons, Jagat R. Kanwar, Rupinder K. Kanwar

Tumoral BRD4 expression in lymph node-negative breast cancer: association with T-bet+ tumor-infiltrating lymphocytes and disease-free survival

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Minji Lee, Farnoosh Tayyari, Dushanthi Pinnaduwage, Jane Bayani, John M. S. Bartlett, Anna Marie Mulligan, Shelley B. Bull, Irene L. Andrulis

Return to work in prostate cancer survivors – findings from a prospective study on occupational reintegration following a cancer rehabilitation program

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Anneke Ullrich, Hilke Maria Rath, Ullrich Otto, Christa Kerschgens, Martin Raida, Christa Hagen-Aukamp, Corinna Bergelt

Genomic alterations accompanying tumour evolution in colorectal cancer: tracking the differences between primary tumours and synchronous liver metastases by whole-exome sequencing

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M. B. Mogensen, M. Rossing, O. Østrup, P. N. Larsen, P. J. Heiberg Engel, L. N. Jørgensen, E. V. Hogdall, J. Eriksen, P. Ibsen, P. Jess, M. Grauslund, H. J. Nielsen, F. C. Nielsen, B. Vainer, K. Osterlind

Investigation of the key chemical structures involved in the anticancer activity of disulfiram in A549 non-small cell lung cancer cell line

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Kate Butcher, Vinodh Kannappan, Rajagopal Sharada Kilari, Mark R. Morris, Christopher McConville, Angel L. Armesilla, Weiguang Wang

The LEAD study protocol: a mixed-method cohort study evaluating the lung cancer diagnostic and pre-treatment pathways of patients from Culturally and Linguistically Diverse (CALD) backgrounds compared to patients from Anglo-Australian backgrounds

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• Study protocol

Danielle Mazza, Xiaoping Lin, Fiona M. Walter, Jane M. Young, David J. Barnes, Paul Mitchell, Bianca Brijnath, Andrew Martin, Jon D. Emery

Influence of pre-transplant minimal residual disease on prognosis after Allo-SCT for patients with acute lymphoblastic leukemia: systematic review and meta-analysis

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Zhenglei Shen, Xuezhong Gu, Wenwen Mao, Liefen Yin, Ling Yang, Zhe Zhang, Kunmei Liu, Lilan Wang, Yunchao Huang

Rapidly declining skeletal muscle mass predicts poor prognosis of hepatocellular carcinoma treated with transcatheter intra-arterial therapies

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Takamasa Kobayashi, Hirokazu Kawai, Oki Nakano, Satoshi Abe, Hiroteru Kamimura, Akira Sakamaki, Kenya Kamimura, Atsunori Tsuchiya, Masaaki Takamura, Satoshi Yamagiwa, Shuji Terai

Tailored exercise interventions to reduce fatigue in cancer survivors: study protocol of a randomized controlled trial

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• Study protocol

Rosie Twomey, Tristan Martin, John Temesi, S. Nicole Culos-Reed, Guillaume Y. Millet

Mutation allele frequency threshold does not affect prognostic analysis using next-generation sequencing in oral squamous cell carcinoma

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Jie Ma, Yong Fu, Yao-yao Tu, Ying Liu, Yi-ran Tan, Wu-tong Ju, Curtis R. Pickering, Jeffrey N. Myers, Zhi-yuan Zhang, Lai-ping Zhong

Regulation of the oncogenic phenotype by the nuclear body protein ZC3H8

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John A. Schmidt, Keith G. Danielson, Emily R. Duffner, Sara G. Radecki, Gerard T. Walker, Amber Shelton, Tianjiao Wang, Janice E. Knepper

Moving targets in 4D-CTs versus MIP and AIP: comparison of patients data to phantom data

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Kai Joachim Borm, Markus Oechsner, Moritz Wiegandt, Andreas Hofmeister, Stephanie E. Combs, Marciana Nona Duma

Mitotic count can predict tamoxifen benefit in postmenopausal breast cancer patients while Ki67 score cannot

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Karin Beelen, Mark Opdam, Tesa Severson, Rutger Koornstra, Andrew Vincent, Jelle Wesseling, Joyce Sanders, Jan Vermorken, Paul van Diest, Sabine Linn

Resectable pancreatic adenocarcinoma neo-adjuvant FOLF(IRIN)OX-based chemotherapy - a multicenter, non-comparative, randomized, phase II trial (PANACHE01-PRODIGE48 study)

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• Study protocol

Lilian Schwarz, Dewi Vernerey, Jean-Baptiste Bachet, Jean-Jacques Tuech, Fabienne Portales, Pierre Michel, Antonio Sa Cunha

S100A4 suppresses cancer stem cell proliferation via interaction with the IKK/NF-κB signaling pathway

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Yongtong Zhu, Yao Zhou, Xuan Zhou, Yangchun Guo, Daxiong Huang, Jialin Zhang, Chunyan Wang, Longmei Cai

Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors

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Elham Barazeghi, Surendra Prabhawa, Olov Norlén, Per Hellman, Peter Stålberg, Gunnar Westin

Incidence and risk factors of subsyndromal delirium after curative resection of gastric cancer

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Heesung Hwang, Kwang-Min Lee, Kyung-Lak Son, Dooyoung Jung, Won-Hyoung Kim, Joo-Young Lee, Seong-Ho Kong, Yun-Suhk Suh, Hyuk-Joon Lee, Han-Kwang Yang, Bong-Jin Hahm

Classification of gallbladder cancer by assessment of CD8+ TIL and PD-L1 expression

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Jianzhen Lin, Junyu Long, Xueshuai Wan, Jingci Chen, Yi Bai, Anqiang Wang, Xiaobo Yang, Yan Wu, Simon C. Robson, Xinting Sang, Haitao Zhao

Prognosis of ovarian cancer in women with type 2 diabetes using metformin and other forms of antidiabetic medication or statins: a retrospective cohort study

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Elina Urpilainen, Mikko Marttila, Ari Hautakoski, Martti Arffman, Reijo Sund, Pirjo Ilanne-Parikka, Reetta Arima, Jenni Kangaskokko, Ulla Puistola, Marianne Hinkula, Esa Läärä

Cumulative smoking dose affects the clinical outcomes of EGFR-mutated lung adenocarcinoma patients treated with EGFR-TKIs: a retrospective study

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In Ae Kim, Jong Sik Lee, Hee Joung Kim, Wan Seop Kim, Kye Young Lee

Pancreatic adenocarcinoma: insights into patterns of recurrence and disease behavior

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Ibrahim H. Sahin, Harold Elias, Joanne F. Chou, Marinela Capanu, Eileen M. O’Reilly

Impact of vitamin D on pathological complete response and survival following neoadjuvant chemotherapy for breast cancer: a retrospective study

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Marie Viala, Akiko Chiba, Simon Thezenas, Laure Delmond, Pierre-Jean Lamy, Sarah L. Mott, Mary C. Schroeder, Alexandra Thomas, William Jacot

An open-label, randomized, phase II trial evaluating the efficacy and safety of standard of care with or without bevacizumab in platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer patients previously treated with bevacizumab for front-line or platinum-sensitive ovarian cancer: rationale, design, and methods of the Japanese Gynecologic Oncology Group study JGOG3023

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• Study protocol

Tadahiro Shoji, Shinichi Komiyama, Junzo Kigawa, Hiroshi Tanabe, Kazuyoshi Kato, Hiroaki Itamochi, Hiroyuki Fujiwara, Shoji Kamiura, Tetsutaro Hamano, Toru Sugiyama

Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells

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Dandan Li, John E. Mullinax, Taylor Aiken, Hongwu Xin, Gordon Wiegand, Andrew Anderson, Snorri Thorgeirsson, Itzhak Avital, Udo Rudloff

Clinical significance of FBXO17 gene expression in high-grade glioma

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Di Du, Jian Yuan, Wencai Ma, Jing Ning, John N. Weinstein, Xianrui Yuan, Greg N. Fuller, Yuexin Liu

Validation of insulin-like growth factor-1 as a prognostic parameter in patients with hepatocellular carcinoma in a European cohort

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Yvonne Huber, Franziska Bierling, Christian Labenz, Sandra Koch, Irene Schmidtmann, Roman Kloeckner, Sebastian Schotten, Tobias Huber, Hauke Lang, Marcus A. Woerns, Peter R. Galle, Arndt Weinmann, Julia Weinmann-Menke

Once weekly paclitaxel associated with a fixed dose of oral metronomic cyclophosphamide: a dose-finding phase 1 trial

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Diane Pannier, Antoine Adenis, Emilie Bogart, Eric Dansin, Stéphanie Clisant-Delaine, Emilie Decoupigny, Anne Lesoin, Eric Amela, Sandrine Ducornet, Jean-Pierre Meurant, Marie-Cécile Le Deley, Nicolas Penel

Long-term outcomes and recurrence pattern of 18F-FDG PET-CT complete metabolic response in the first-line treatment of metastatic colorectal cancer: a lesion-based and patient-based analysis

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Keith W. H. Chiu, Ka-On Lam, H. An, Gavin T. C. Cheung, Johnny K. S. Lau, Tim-Shing Choy, Victor H. F. Lee

Cytoplasmic TRAIL-R1 is a positive prognostic marker in PDAC

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Jan-Paul Gundlach, Charlotte Hauser, Franka Maria Schlegel, Christine Böger, Christian Röder, Christoph Röcken, Thomas Becker, Jan-Hendrik Egberts, Holger Kalthoff, Anna Trauzold

Removal of pectoral muscle based on topographic map and shape-shifting silhouette

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Bushra Mughal, Nazeer Muhammad, Muhammad Sharif, Amjad Rehman, Tanzila Saba

Non-traumatic splenic rupture - a rare first presentation of diffuse large B-cell lymphoma and a review of the literature

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• Case report

Kogulakrishnan Kaniappan, Christopher Thiam Seong Lim, Pek Woon Chin

Gefitinib provides similar effectiveness and improved safety than erlotinib for east Asian populations with advanced non–small cell lung cancer: a meta-analysis

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Wenxiong Zhang, Yiping Wei, Dongliang Yu, Jianjun Xu, Jinhua Peng

Trends in incidence, mortality and survival in women with breast cancer from 1985 to 2012 in Granada, Spain: a population-based study

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José Antonio Baeyens-Fernández, Elena Molina-Portillo, Marina Pollán, Miguel Rodríguez-Barranco, Rosario Del Moral, Lorenzo Arribas-Mir, Emilio Sánchez-Cantalejo Ramírez, María-José Sánchez

Achieving optimal response at 12 months is associated with a better health-related quality of life in patients with chronic myeloid leukemia: a prospective, longitudinal, single center study

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Lu Yu, Haibo Wang, Darko Milijkovic, Xiaojun Huang, Qian Jiang

Enrichment of cancer stem cells via β-catenin contributing to the tumorigenesis of hepatocellular carcinoma

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Harshul Pandit, Yan Li, Xuanyi Li, Weizhong Zhang, Suping Li, Robert C. G. Martin

Barrett’s oESophagus trial 3 (BEST3): study protocol for a randomised controlled trial comparing the Cytosponge-TFF3 test with usual care to facilitate the diagnosis of oesophageal pre-cancer in primary care patients with chronic acid reflux

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• Study protocol

Judith Offman, Beth Muldrew, Maria O’Donovan, Irene Debiram-Beecham, Francesca Pesola, Irene Kaimi, Samuel G. Smith, Ashley Wilson, Zohrah Khan, Pierre Lao-Sirieix, Benoit Aigret, Fiona M. Walter, Greg Rubin, Steve Morris, Christopher Jackson, Peter Sasieni, Rebecca C. Fitzgerald

Prediction of three lipid derivatives for postoperative gastric cancer mortality: the Fujian prospective investigation of cancer (FIESTA) study

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Dan Hu, Feng Peng, Xiandong Lin, Gang Chen, Binying Liang, Ying Chen, Chao Li, Hejun Zhang, Guohui Fan, Guodong Xu, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu

TRH site-specific methylation in oral and oropharyngeal squamous cell carcinoma

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C. Puttipanyalears, A. Arayataweegool, K. Chalertpet, P. Rattanachayoto, P. Mahattanasakul, N. Tangjaturonsasme, V. Kerekhanjanarong, A. Mutirangura, N. Kitkumthorn

Postoperative hepatic arterial chemotherapy in high-risk patients as adjuvant treatment after resection of colorectal liver metastases - a randomized phase II/III trial – PACHA-01 (NCT02494973)

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• Study protocol

Diane Goéré, Jean-Pierre Pignon, Maximiliano Gelli, Dominique Elias, Léonor Benhaim, Frédéric Deschamps, Caroline Caramella, Valérie Boige, Michel Ducreux, Thierry de Baere, David Malka

The comparative effectiveness of decision aids in diverse populations with early stage prostate cancer: a study protocol for a cluster-randomized controlled trial in the NCI Community Oncology Research Program (NCORP), Alliance A191402CD

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• Study protocol

Joel E. Pacyna, Simon Kim, Kathleen Yost, Hillary Sedlacek, Daniel Petereit, Judith Kaur, Bruce Rapkin, Robert Grubb, Electra Paskett, George J. Chang, Jeff Sloan, Ethan Basch, Brittny Major, Paul Novotny, John Taylor, Jan Buckner, J. Kellogg Parsons, Michael Morris, Jon C. Tilburt

A multicenter study investigating the molecular fingerprint of psychological resilience in breast cancer patients: study protocol of the SCAN-B resilience study

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• Study protocol

Ulrika Axelsson, Lisa Rydén, Per Johnsson, Patrik Edén, Johanna Månsson, Ingalill Rahm Hallberg, Carl A. K. Borrebaeck

Safety and tolerability of quizartinib, a FLT3 inhibitor, in advanced solid tumors: a phase 1 dose-escalation trial

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Kyriakos P. Papadopoulos, Eytan Ben-Ami, Amita Patnaik, Denise Trone, Jianke Li, George D. Demetri

Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines

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Tomohiro Kozako, Paolo Mellini, Takeo Ohsugi, Akiyoshi Aikawa, Yu-ichiro Uchida, Shin-ichiro Honda, Takayoshi Suzuki

Favorable mortality-to-incidence ratios of kidney Cancer are associated with advanced health care systems

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Wen-Wei Sung, Shao-Chuan Wang, Tzuo-Yi Hsieh, Cheng-Ju Ho, Cheng-Yu Huang, Yu-Lin Kao, Wen-Jung Chen, Sung-Lang Chen

Bcl-2-associated athanogene 3(BAG3) is associated with tumor cell proliferation, migration, invasion and chemoresistance in colorectal cancer

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Ning Li, Minghong Chen, Yansha Cao, Hua Li, Jinping Zhao, Zhenhua Zhai, Fu Ren, Keyan Li

RandomiSed clinical trial assessing Use of an anti-inflammatoRy aGent in attenUating peri-operatiVe inflAmmatioN in non-meTastatic colon cancer – the S.U.R.G.U.V.A.N.T. trial

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H. Paul Redmond, Peter M. Neary, Marcel Jinih, Emer O’Connell, Niamh Foley, Rolf W. Pfirrmann, Jiang H. Wang, D. Peter O’Leary

Body mass index and cancer risk among Chinese patients with type 2 diabetes mellitus

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Hui-lin Xu, Min-lu Zhang, Yu-jie Yan, Fang Fang, Qi Guo, Dong-li Xu, Zuo-feng Zhang, Fen Zhang, Nai-qing Zhao, Wang-hong Xu, Guo-you Qin

Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers

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Felix Kordowski, Julia Kolarova, Clemens Schafmayer, Stephan Buch, Torsten Goldmann, Sebastian Marwitz, Christian Kugler, Swetlana Scheufele, Volker Gassling, Christopher G. Németh, Mario Brosch, Jochen Hampe, Ralph Lucius, Christian Röder, Holger Kalthoff, Reiner Siebert, Ole Ammerpohl, Karina Reiss

Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice

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Mu Xu, Hui-Hua Chang, Xiaoman Jung, Aune Moro, Caroline Ei Ne Chou, Jonathan King, O. Joe Hines, James Sinnett-Smith, Enrique Rozengurt, Guido Eibl

Liver cancer mortality trends in South Africa: 1999–2015

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Daniel Mak, Mazvita Sengayi, Wenlong C. Chen, Chantal Babb de Villiers, Elvira Singh, Anna Kramvis

LC-MS based sphingolipidomic study on A549 human lung adenocarcinoma cell line and its taxol-resistant strain

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Hao Huang, Tian-Tian Tong, Lee-Fong Yau, Cheng-Yu Chen, Jia-Ning Mi, Jing-Rong Wang, Zhi-Hong Jiang

Second primary cancer after primary peritoneal, epithelial ovarian, and fallopian tubal cancer: a retrospective study

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Myong Cheol Lim, Young-Joo Won, Jiwon Lim, Tahereh Salehi, Chong Woo Yoo, Robert E. Bristow

Improved outcome in patients following autologous stem cell transplantation for multiple myeloma in south eastern Norway 2001–2010: a retrospective, population based analysis

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Jon-Magnus Tangen, Geir Erland Tjønnfjord, Nina Gulbrandsen, Tobias Gedde-Dahl, Espen Stormorken, Kristina Anderson, Camilla Dao Vo, Fredrik Hellem Schjesvold

Diffuse parenchymal pulmonary amyloidosis associated with multiple myeloma: a case report and systematic review of the literature

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• Case report

Yin Liu, Zhibin Jin, Haiyan Zhang, Yingwei Zhang, Minke Shi, Fanqing Meng, Qi Sun, Hourong Cai

A prospective phase I study of hypo-fractionated neoadjuvant radiotherapy for locally advanced gastric cancer

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Ning Li, Xin Wang, Yuan Tang, Dongbing Zhao, Yihebali Chi, Lin Yang, Liming Jiang, Jun Jiang, Wenyang Liu, Yu Tang, Hui Fang, Yueping Liu, Yongwen Song, Shulian Wang, Jing Jin, Yexiong Li

International pilot external quality assessment scheme for analysis and reporting of circulating tumour DNA

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Cleo Keppens, Elisabeth M. C. Dequeker, Simon J. Patton, Nicola Normanno, Francesca Fenizia, Rachel Butler, Melanie Cheetham, Jennifer A. Fairley, Hannah Williams, Jacqueline A. Hall, Ed Schuuring, Zandra C. Deans

Fatty acid oxidation is associated with proliferation and prognosis in breast and other cancers

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Aziz Aiderus, Michael A. Black, Anita K. Dunbier

An elderly patient presenting with a primary spinal multifocal intradural extramedullary pilocytic astrocytoma: a case report and review of the literature

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• Astrozytom
• Case report

Devin McBride, Zaid Aljuboori, Eyas M. Hattab, Richard Downs, Shiao Woo, Brian Williams, Joseph Neimat, Eric Burton

Comparison of local tumor control in patients with HCC treated with SBRT or TACE: a propensity score analysis

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Dominik Bettinger, Eleni Gkika, Michael Schultheiss, Nicolas Glaser, Sophie Lange, Lars Maruschke, Nico Buettner, Simon Kirste, Ursula Nestle, Anca-Ligia Grosu, Robert Thimme, Thomas B. Brunner

Irinotecan-platinum combination therapy for previously untreated extensive-stage small cell lung cancer patients: a meta-analysis

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Fei Xu, Xiaoli Ren, Yuan Chen, Qianxia Li, Ruichao Li, Yu Chen, Shu Xia

Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins

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Lan Lan, Hao Liu, Amber R. Smith, Carl Appelman, Jia Yu, Sarah Larsen, Rebecca T. Marquez, Xiaoqing Wu, Frank Y. Liu, Philip Gao, Ragul Gowthaman, John Karanicolas, Roberto N. De Guzman, Steven Rogers, Jeffrey Aubé, Kristi L. Neufeld, Liang Xu

Comparison of cervical cancer screening among women with and without hysterectomies: a nationwide population-based study in Korea

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Ji-Yeon Shin, Kui Son Choi, Mina Suh, Boyoung Park, Jae Kwan Jun

MRI in predicting the response of gastrointestinal stromal tumor to targeted therapy: a patient-based multi-parameter study

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Lei Tang, Jian Li, Zi-Yu Li, Xiao-Ting Li, Ji-Fang Gong, Jia-Fu Ji, Ying-Shi Sun, Lin Shen

Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment

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Diego Tosi, Esther Pérez-Gracia, Salima Atis, Nadia Vié, Eve Combès, Mélissa Gabanou, Christel Larbouret, Marta Jarlier, Caroline Mollevi, Adeline Torro, Maguy Del Rio, Pierre Martineau, Céline Gongora

CREB3L1 as a potential biomarker predicting response of triple negative breast cancer to doxorubicin-based chemotherapy

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Bray Denard, Sharon Jiang, Yan Peng, Jin Ye

Early increase in blood supply (EIBS) is associated with tumor risk in the Azoxymethane model of colon cancer

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Sarah Ruderman, Adam Eshein, Vesta Valuckaite, Urszula Dougherty, Anas Almoghrabi, Andrew Gomes, Ajaypal Singh, Baldeep Pabla, Hemant K. Roy, John Hart, Marc Bissonnette, Vani Konda, Vadim Backman

Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma

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• Research article

Linyan Chen, Hao Zeng, Jiapeng Yang, Yuqing Lu, Dan Zhang, Jinggan Wang, Chienyun Kuang, Sha Zhu, Manni Wang, Xuelei Ma

Hornerin promotes tumor progression and is associated with poor prognosis in hepatocellular carcinoma

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• Research article

Shun-Jun Fu, Shun-Li Shen, Shao-Qiang Li, Yun-Peng Hua, Wen-Jie Hu, BeiChu Guo, Bao-Gang Peng

A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells

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• Research article

Bo Wang, Dongping Li, Rocio Rodriguez-Juarez, Allison Farfus, Quinn Storozynsky, Megan Malach, Emily Carpenter, Jody Filkowski, Anne E. Lykkesfeldt, Olga Kovalchuk

Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes

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Melanie Kucherlapati

Hypoxia promotes acquisition of aggressive phenotypes in human malignant mesothelioma

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• Research article

Myung-Chul Kim, Sung-Hyun Hwang, Na-Yon Kim, Hong-Seok Lee, Sumin Ji, Yeseul Yang, Yongbaek Kim

Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients

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Seyed Hamidreza Mahmoudpour, Obul Reddy Bandapalli, Miguel Inácio da Silva Filho, Chiara Campo, Kari Hemminki, Hartmut Goldschmidt, Maximilian Merz, Asta Försti

Colorectal liver metastases: surgery versus thermal ablation (COLLISION) – a phase III single-blind prospective randomized controlled trial

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• Study protocol

Robbert S. Puijk, Alette H. Ruarus, Laurien G. P. H. Vroomen, Aukje A. J. M. van Tilborg, Hester J. Scheffer, Karin Nielsen, Marcus C. de Jong, Jan J. J. de Vries, Babs M. Zonderhuis, Hasan H. Eker, Geert Kazemier, Henk Verheul, Bram B. van der Meijs, Laura van Dam, Natasha Sorgedrager, Veerle M. H. Coupé, Petrousjka M. P. van den Tol, Martijn R. Meijerink, Warner Prevoo, Niels Kok, Arjen L. Diederik, Gert Jan Spaargaren, Colin Sietses, Tjarda N. van Heek, Gian Piero Serafino, Jurgen J. Futterer, Peter B. van den Boezem, Martijn Stommel, Hans de Wilt, Mark Arntz, Sjoerd Jenniskens, Mark Besselink, Otto M. van Delden, Thomas M. van Gulik, Pieter J. Tanis, Krijn P. van Lienden, Mark C. Burgmans, Rutger-Jan Swijnenburg, Arian R. van Erkel, Henk H. Hartgrink, Jan Peringa, Hendrik Marsman, Peter C. A. Jacobs, Michael F. Gerhards, Christiaan van der Leij, Rutger Brans, Marielle M. E. Coolsen, Kees C. H. C. Dejong, Ronald van Dam, Abbas Millad Solouki, Johan A. Dol, Ted W. F. Vink, Eric R. Manusama, Gijs A. Patijn, Vincent B. Nieuwenhuijs, Mark A. J. Meijer, Hans Torrenga, Eric D. J. A. Sonneveld, Jan-Willem W. D. de Waard, Joris J. A. Joosten, Cees Verhoef, Adriaan Moelker, Dirk Jan Grunhagen, Bas Groot Koerkamp, Jeroen Hagendoorn, I.Q Molenaar, Rutger C. G. Bruijnen, Karin C. M. J. van Nieuwkerk, Peter van de Ven, Astrid de Wind, Han Anema, Jacob de Bakker, Martijn W. H. Leenders, Tessa Hellingman, Nicole van Grieken, Sanne Nieuwenhuizen, Bart Geboers, David J. Breen, Luca Aldrighetti, Francesco De Cobelli, Francesca Ratti, Paolo Marra, Thomas Albrecht, P. D. Muller, Cornelis van Kuijk

Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes

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Mona M. Saber, Abdulaziz M. Al-mahallawi, Noha N. Nassar, Björn Stork, Samia A. Shouman

Galectin 3 expression in regional lymph nodes and lymph node metastases of oral squamous cell carcinomas

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Falk Wehrhan, Maike Büttner-Herold, Luitpold Distel, Jutta Ries, Patrick Moebius, Raimund Preidl, Carol I. Geppert, Friedrich W. Neukam, Marco Kesting, Manuel Weber

Low serum gastrin associated with ER+ breast cancer development via inactivation of CCKBR/ERK/P65 signaling

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Li-Li Meng, Jing-Long Wang, Shu-Ping Xu, Li-Dong Zu, Zhao-Wen Yan, Jian-Bing Zhang, Ya-Qin Han, Guo-Hui Fu

Gefitinib successfully administered in a lung cancer patient with leptomeningeal carcinomatosis after erlotinib-induced pneumatosis intestinalis

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• Lungenkarzinome
• Case report

Hironori Uruga, Shuhei Moriguchi, Yui Takahashi, Kazumasa Ogawa, Kyoko Murase, Sayaka Mochizuki, Shigeo Hanada, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa, Kazuma Kishi

PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue

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Tomoya Yokota, Masakuni Serizawa, Ayumu Hosokawa, Kimihide Kusafuka, Keita Mori, Toshiro Sugiyama, Yasuhiro Tsubosa, Yasuhiro Koh

Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers

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Xiaodong Sun, Tongzhong Ju, Richard D. Cummings

Simultaneous detection of lung fusions using a multiplex RT-PCR next generation sequencing-based approach: a multi-institutional research study

• Open Access
• Technical advance

Cecily P. Vaughn, José Luis Costa, Harriet E. Feilotter, Rosella Petraroli, Varun Bagai, Anna Maria Rachiglio, Federica Zito Marino, Bastiaan Tops, Henriette M. Kurth, Kazuko Sakai, Andrea Mafficini, Roy R. L. Bastien, Anne Reiman, Delphine Le Corre, Alexander Boag, Susan Crocker, Michel Bihl, Astrid Hirschmann, Aldo Scarpa, José Carlos Machado, Hélène Blons, Orla Sheils, Kelli Bramlett, Marjolijn J. L. Ligtenberg, Ian A. Cree, Nicola Normanno, Kazuto Nishio, Pierre Laurent-Puig

Lesions of “uncertain malignant potential” in the breast (B3) identified with mammography screening

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Christiane Richter-Ehrenstein, Katharina Maak, Sonja Röger, Tilman Ehrenstein

A multi-center, double blind randomized controlled trial evaluating flap fixation after mastectomy using sutures or tissue glue versus conventional closure: protocol for the Seroma reduction After Mastectomy (SAM) trial

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• Study protocol

J. van Bastelaar, R. Granzier, L. M. van Roozendaal, G. Beets, C. D. Dirksen, Y. Vissers

Tracing the path of cancer initiation: the AA protein-based model for cancer genesis

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• Debate

Adouda Adjiri

Malignant canine mammary epithelial cells shed exosomes containing differentially expressed microRNA that regulate oncogenic networks

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• Research article

Eric J. Fish, Kristopher J. Irizarry, Patricia DeInnocentes, Connor J. Ellis, Nripesh Prasad, Anthony G. Moss, R. Curt Bird

A novel approach to monitoring the efficacy of anti-tumor treatments in animal models: combining functional MRI and texture analysis

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Ming Meng, Huadan Xue, Jing Lei, Qin Wang, Jingjuan Liu, Yuan Li, Ting Sun, Haiyan Xu, Zhengyu Jin

Circular RNA: new star, new hope in cancer

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• Debate

Zikang Zhang, Qing Xie, Dongmei He, Yuan Ling, Yuchao Li, Jiangbin Li, Hua Zhang

Effect of surgical liver resection on circulating tumor cells in patients with hepatocellular carcinoma

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• Research article

Jing-jing Yu, Wei Xiao, Shui-lin Dong, Hui-fang Liang, Zhi-wei Zhang, Bi-xiang Zhang, Zhi-yong Huang, Yi-fa Chen, Wan-guang Zhang, Hong-ping Luo, Qian Chen, Xiao-ping Chen

Expression of oxidized protein tyrosine phosphatase and γH2AX predicts poor survival of gastric carcinoma patients

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Usama Khamis Hussein, Ho Sung Park, Jun Sang Bae, Kyoung Min Kim, Yun Jo Chong, Chan Young Kim, Keun Sang Kwon, Myoung Ja Chung, Ho Lee, Myoung Jae Kang, Woo Sung Moon, Kyu Yun Jang

The crucial role of blood VEGF kinetics in patients with locally advanced esophageal squamous cell carcinoma receiving curative concurrent chemoradiotherapy

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Yen-Hao Chen, Hung-I Lu, Chien-Ming Lo, Yu-Ming Wang, Shang-Yu Chou, Chang-Chun Hsiao, Chao-Cheng Huang, Li-Hsueh Shih, Su-Wei Chen, Shau-Hsuan Li

Poor prognosis of nucleophosmin overexpression in solid tumors: a meta-analysis

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Siying Chen, Hairong He, Yan Wang, Leichao Liu, Yang Liu, Haisheng You, Yalin Dong, Jun Lyu

Successfully treatment by eribulin in visceral crisis: a case of lymphangitic carcinomatosis from metastatic breast cancer

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• Mammakarzinom
• Case report

Jean-David Fumet, Mark Wickre, Jean-Philippe Jacquot, Marie-Helene Bizollon, Adrien Melis, André Vanoli, Erika Viel

Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model

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Tasuku Kiyuna, Yasunori Tome, Takashi Murakami, Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Masuyo Miyake, Yunfeng Li, Scott D. Nelson, Sarah M. Dry, Arun S. Singh, Tara A. Russell, Irmina Elliott, Shree Ram Singh, Fuminori Kanaya, Fritz C. Eilber, Robert M. Hoffman

Early detection of colorectal adenocarcinoma: a clinical decision support tool based on plasma porphyrin accumulation and risk factors

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Manuela Lualdi, Adalberto Cavalleri, Luigi Battaglia, Ambrogio Colombo, Giulia Garrone, Daniele Morelli, Emanuele Pignoli, Elisa Sottotetti, Ermanno Leo

A primary undifferentiated pleomorphic sarcoma of the lumbosacral region harboring a LMNA-NTRK1 gene fusion with durable clinical response to crizotinib: a case report

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• Case report

Ning Zhou, Reinhold Schäfer, Tao Li, Meiyu Fang, Luying Liu

Impact of viral presence in tumor on gene expression in non-small cell lung cancer

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• Research article

Youngchul Kim, Christine M. Pierce, Lary A. Robinson

Evaluation of postoperative ascites after somatostatin infusion following hepatectomy for hepatocellular carcinoma by laparotomy: a multicenter randomized double-blind controlled trial (SOMAPROTECT)

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• Study protocol

Kayvan Mohkam, Michel Rayar, Jean-Philippe Adam, Fabrice Muscari, Agnès Rode, Philippe Merle, Pierre Pradat, Stéphanie Bauler, Isabelle Delfour, Laurence Chiche, Christian Ducerf, Karim Boudjema, Mickaël Lesurtel, Christophe Laurent, Jean-Yves Mabrut

Study protocol for a controlled trial of an eHealth system utilising patient reported outcome measures for personalised treatment and care: PROMPT-Care 2.0

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• Study protocol

Afaf Girgis, Ivana Durcinoska, Martha Gerges, Nasreen Kaadan, Anthony Arnold, Joseph Descallar, Geoff P. Delaney, Sandra Avery, Martin Carolan, Stephen Della-Fiorentina, Kenneth Masters, Andrew Miller, Weng Ng, Tiffany Sandell, Thomas T. Tran, Janelle V. Levesque

Opisthorchiasis with proinflammatory cytokines (IL-1β and TNF-α) polymorphisms influence risk of intrahepatic cholangiocarcinoma in Thailand: a nested case-control study

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• Research article

Supannee Promthet, Nopparat Songserm, Somkiattiyos Woradet, Chamsai Pientong, Tipaya Ekalaksananan, Surapon Wiangnon, Akhtar Ali

Association between cyclooxygenase-2 (COX-2) 8473 T > C polymorphism and cancer risk: a meta-analysis and trial sequential analysis

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• Research article

Qiuping Li, Chao Ma, Zhihui Zhang, Suhua Chen, Weiguo Zhi, Lei Zhang, Guoyao Zhang, Lei Shi, Fei Cao, Tianjiang Ma

ALDH1A3 upregulation and spontaneous metastasis formation is associated with acquired chemoresistance in colorectal cancer cells

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Erika Durinikova, Zuzana Kozovska, Martina Poturnajova, Jana Plava, Zuzana Cierna, Andrea Babelova, Roman Bohovic, Silvia Schmidtova, Miroslav Tomas, Lucia Kucerova, Miroslava Matuskova

Survival and prognostic factors in conventional central chondrosarcoma

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Julian Fromm, Alexander Klein, Andrea Baur-Melnyk, Thomas Knösel, Lars Lindner, Christof Birkenmaier, Falk Roeder, Volkmar Jansson, Hans Roland Dürr

Association of tamoxifen resistance and lipid reprogramming in breast cancer

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Susanne Hultsch, Matti Kankainen, Lassi Paavolainen, Ruusu-Maaria Kovanen, Elina Ikonen, Sara Kangaspeska, Vilja Pietiäinen, Olli Kallioniemi

RESPONDER – diagnosis of pathological complete response by vacuum-assisted biopsy after neoadjuvant chemotherapy in breast Cancer - a multicenter, confirmative, one-armed, intra-individually-controlled, open, diagnostic trial

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• Study protocol

Joerg Heil, Peter Sinn, Hannah Richter, André Pfob, Benedikt Schaefgen, André Hennigs, Fabian Riedel, Bettina Thomas, Marc Thill, Markus Hahn, Jens-Uwe Blohmer, Sherko Kuemmel, Maria Margarete Karsten, Mattea Reinisch, John Hackmann, Toralf Reimer, Geraldine Rauch, Michael Golatta

Low level of isocitrate dehydrogenase 1 predicts unfavorable postoperative outcomes in patients with clear cell renal cell carcinoma

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Pingcuo Laba, Jianfeng Wang, Jin Zhang

Contribution of KCTD12 to esophageal squamous cell carcinoma

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Mohammad Reza Abbaszadegan, Negin Taghehchian, Liping Li, Azadeh Aarabi, Meysam Moghbeli

Protocol for the P3BEP trial (ANZUP 1302): an international randomised phase 3 trial of accelerated versus standard BEP chemotherapy for adult and paediatric male and female patients with intermediate and poor-risk metastatic germ cell tumours

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• Study protocol

Nicola J. Lawrence, Howard Chan, Guy Toner, Martin R. Stockler, Andrew Martin, Sonia Yip, Nicole Wong, Annie Yeung, Danish Mazhar, Farzana Pashankar, Lindsay Frazier, Ray McDermott, Roderick Walker, Hsiang Tan, Ian D. Davis, Peter Grimison

An in-silico study examining the induction of apoptosis by Cryptotanshinone in metastatic melanoma cell lines

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Radhika S. Saraf, Aniruddha Datta, Chao Sima, Jianping Hua, Rosana Lopes, Michael Bittner

Daphnane diterpenes inhibit the metastatic potential of B16F10 murine melanoma cells in vitro and in vivo

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Myra O. Villareal, Yuki Sato, Kyoko Matsuyama, Hiroko Isoda

Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells

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Wenming Liu, Yanyun Fan, Ying Shi, Zhenhe Lin, Xiaoxiao Huang, Wei Huang, Dongyan Shen, Zhongquan Qi

Using hospital registries in Australia to extend data availability on vulval cancer treatment and survival

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David Roder, Margaret Davy, Sid Selva-Nayagam, Sellvakumaram Paramasivam, Jacqui Adams, Dorothy Keefe, Ian Olver, Caroline Miller, Elizabeth Buckley, Kate Powell, Kellie Fusco, Dianne Buranyi-Trevarton, Martin K. Oehler

Local response and pathologic fractures following stereotactic body radiotherapy versus three-dimensional conformal radiotherapy for spinal metastases - a randomized controlled trial

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Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Katharina Hees, Thomas Bruckner, Tilman Bostel, Rami Ateyah El Shafie, Thomas Welzel, Nils Henrik Nicolay, Jürgen Debus, Harald Rief

The impact of mammography screening programmes on incidence of advanced breast cancer in Europe: a literature review

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M. J. M. Broeders, P. Allgood, S. W. Duffy, S. Hofvind, I. D. Nagtegaal, E. Paci, S. M. Moss, L. Bucchi

Robot assisted radical cystectomy versus open radical cystectomy in bladder cancer (RACE): study protocol of a non-randomized comparative effectiveness study

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• Study protocol

C. J. Wijburg, C. T. J. Michels, J. R. Oddens, J. P. C. Grutters, J. A. Witjes, M. M. Rovers

Angiogenesis and radiological tumor growth in patients with glioblastoma

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Vilde Elisabeth Mikkelsen, Anne Line Stensjøen, Unn Sophie Granli, Erik Magnus Berntsen, Øyvind Salvesen, Ole Solheim, Sverre Helge Torp

A prospective cohort examination of haematological parameters in relation to cancer death and incidence: the Busselton Health Study

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Niwansa Adris, Anita Chai Geik Chua, Matthew William Knuiman, Mark Laurence Divitini, Debbie Trinder, John Kevin Olynyk

Rationale and design of the Caloric Restriction and Exercise protection from Anthracycline Toxic Effects (CREATE) study: a 3-arm parallel group phase II randomized controlled trial in early breast cancer

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• Study protocol

Amy A. Kirkham, D. Ian Paterson, Carla M. Prado, John M. Mackey, Kerry S. Courneya, Edith Pituskin, Richard B. Thompson

Prognostic value of differentiation status in gastric cancer

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Fan Feng, Jinqiang Liu, Fei Wang, Gaozan Zheng, Qiao Wang, Shushang Liu, Guanghui Xu, Man Guo, Xiao Lian, Hongwei Zhang

Impact of breast cancer on prospective memory functioning assessed by virtual reality and influence of sleep quality and hormonal therapy: PROSOM-K study

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• Study protocol

Mylène Duivon, Joy Perrier, Florence Joly, Idlir Licaj, Jean-Michel Grellard, Bénédicte Clarisse, Christelle Lévy, Philippe Fleury, Sophie Madeleine, Nicolas Lefèvre, Géraldine Rauchs, Grégory Lecouvey, Florence Fraisse, Fausto Viader, Francis Eustache, Béatrice Desgranges, Bénédicte Giffard

Relationship between the Ki67 index and its area based approximation in breast cancer

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Muhammad Khalid Khan Niazi, Caglar Senaras, Michael Pennell, Vidya Arole, Gary Tozbikian, Metin N. Gurcan

The plasma glutamate concentration as a complementary tool to differentiate benign PET-positive lung lesions from lung cancer

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K. Vanhove, P. Giesen, O. E. Owokotomo, L. Mesotten, E. Louis, Z. Shkedy, M. Thomeer, P. Adriaensens

Tumor necrosis as a prognostic variable for the clinical outcome in patients with renal cell carcinoma: a systematic review and meta-analysis

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Lijin Zhang, Zhenlei Zha, Wei Qu, Hu Zhao, Jun Yuan, Yejun Feng, Bin Wu

Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

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Vincent Ho, Liping Chung, Amandeep Singh, Vivienne Lea, Askar Abubakar, Stephanie H. Lim, Weng Ng, Mark Lee, Paul de Souza, Joo-Shik Shin, Cheok Soon Lee

Postoperative resveratrol administration improves prognosis of rat orthotopic glioblastomas

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Xue Song, Xiao-Hong Shu, Mo-Li Wu, Xu Zheng, Bin Jia, Qing-You Kong, Jia Liu, Hong Li

Increased insulin-like growth factor 1 production by polyploid adipose stem cells promotes growth of breast cancer cells

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Roberta Fajka-Boja, Annamária Marton, Anna Tóth, Péter Blazsó, Vilmos Tubak, Balázs Bálint, István Nagy, Zoltán Hegedűs, Csaba Vizler, Robert L. Katona

Topical steroid versus placebo for the prevention of radiation dermatitis in head and neck cancer patients receiving chemoradiotherapy: the study protocol of J-SUPPORT 1602 (TOPICS study), a randomized double-blinded phase 3 trial

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• Study protocol

Sadamoto Zenda, Takuhiro Yamaguchi, Tomoya Yokota, Tempei Miyaji, Tomoe Mashiko, Mari Tanaka, Masahito Yonemura, Misaki Takeno, Tomoka Okano, Toshikatsu Kawasaki, Yuko Nakamori, Shinobu Ishii, Sanae Shimada, Miyuki Kanamaru, Yosuke Uchitomi

Determinants of fertility issues experienced by young women diagnosed with breast or gynaecological cancer – a quantitative, cross-cultural study

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• Research article

Aleksandra Sobota, Gozde Ozakinci

Decreased methylation in the SNAI2 and ADAM23 genes associated with de-differentiation and haematogenous dissemination in breast cancers

• Open Access
• Research article

Lenka Kalinkova, Iveta Zmetakova, Bozena Smolkova, Gabriel Minarik, Tatiana Sedlackova, Viera Horvathova Kajabova, Zuzana Cierna, Michal Mego, Ivana Fridrichova

Correction to: Observational study on the prognostic value of testosterone and adiposity in postmenopausal estrogen receptor positive breast cancer patients

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• Correction

Elisabetta Venturelli, Annalisa Orenti, Aline S. C. Fabricio, Giulia Garrone, Roberto Agresti, Biagio Paolini, Chiara Bonini, Massimo Gion, Franco Berrino, Christine Desmedt, Danila Coradini, Elia Biganzoli

CRITICS-II: a multicentre randomised phase II trial of neo-adjuvant chemotherapy followed by surgery versus neo-adjuvant chemotherapy and subsequent chemoradiotherapy followed by surgery versus neo-adjuvant chemoradiotherapy followed by surgery in resectable gastric cancer

• Open Access
• Study protocol

Astrid E. Slagter, Edwin P. M. Jansen, Hanneke W. M. van Laarhoven, Johanna W. van Sandick, Nicole C. T. van Grieken, Karolina Sikorska, Annemieke Cats, Pietje Muller-Timmermans, Maarten C. C. M. Hulshof, Henk Boot, Maartje Los, Laurens V. Beerepoot, Frank P. J. Peters, Geke A. P. Hospers, Boudewijn van Etten, Henk H. Hartgrink, Mark I. van Berge Henegouwen, Grard A. P. Nieuwenhuijzen, Richard van Hillegersberg, Donald L. van der Peet, Heike I. Grabsch, Marcel Verheij

Basal cell adenocarcinoma of the nasopharyngeal minor salivary glands: a case report and review of the literature

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• Case report