Skip to main content
main-content

Zeitschrift

BMC Cancer

BMC Cancer 1/2018

Ausgabe 1/2018

Inhaltsverzeichnis ( 1299 Artikel )

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Feasibility and acceptability of combining cognitive behavioural therapy techniques with swallowing therapy in head and neck cancer dysphagia

J. M. Patterson, M. Fay, C. Exley, E. McColl, M. Breckons, V. Deary

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Identification of fluorescence in situ hybridization assay markers for prediction of disease progression in prostate cancer patients on active surveillance

Katerina Pestova, Adam J. Koch, Charles P. Quesenberry, Jun Shan, Ying Zhang, Amethyst D. Leimpeter, Beth Blondin, Svetlana Sitailo, Lela Buckingham, Jing Du, Huixin Fei, Stephen K. Van Den Eeden

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool

Pablo Cabezas-Sainz, Jorge Guerra-Varela, María J. Carreira, Javier Mariscal, María Roel, Juan A. Rubiolo, Andrés A. Sciara, Miguel Abal, Luis M. Botana, Rafael López, Laura Sánchez

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Heterogeneity of PD-L1 expression in primary tumors and paired lymph node metastases of triple negative breast cancer

Ming Li, Anqi Li, Shuling Zhou, Yan Xu, Yaoxing Xiao, Rui Bi, Wentao Yang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

An inflammation-based cumulative prognostic score system in patients with diffuse large B cell lymphoma in rituximab era

Feifei Sun, Jia Zhu, Suying Lu, Zijun Zhen, Juan Wang, Junting Huang, Zonghui Ding, Musheng Zeng, Xiaofei Sun

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Differential efficacy of cisplatin plus pemetrexed between L858R and Del-19 in advanced EGFR-mutant non-squamous non-small cell lung cancer

Toshihiko Kaneda, Hiroshige Yoshioka, Motohiro Tamiya, Akihiro Tamiya, Akito Hata, Asukaka Okada, Takashi Niwa, Takayuki Shiroyama, Masaki Kanazu, Tadashi Ishida, Nobuyuki Katakami

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Pathological and molecular diagnosis of bilateral inguinal lymph nodes metastases from low-grade endometrial adenocarcinoma: a case report with review of the literature

Anna Myriam Perrone, Giulia Girolimetti, Simona Cima, Ivana Kurelac, Alessandra Livi, Giacomo Caprara, Donatella Santini, Paolo Castellucci, Alessio Giuseppe Morganti, Giuseppe Gasparre, Pierandrea De Iaco

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cribriform and intraductal prostate cancer are associated with increased genomic instability and distinct genomic alterations

René Böttcher, Charlotte F. Kweldam, Julie Livingstone, Emilie Lalonde, Takafumi N. Yamaguchi, Vincent Huang, Fouad Yousif, Michael Fraser, Robert G. Bristow, Theodorus van der Kwast, Paul C. Boutros, Guido Jenster, Geert J. L. H. van Leenders

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Chemokine CCL27 is a novel plasma biomarker for identification the nasopharyngeal carcinoma patients from the Epstein-Barr virus capsid antigen-specific IgA seropositive population

Min-jie Mao, Ning Xue, Xue-ping Wang, Pei-dong Chi, Yi-jun Liu, Qi Huang, Shu-qin Dai, Wan-li Liu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Crizotinib in patients with anaplastic lymphoma kinase-positive advanced non-small cell lung cancer versus chemotherapy as a first-line treatment

Jianya Zhou, Jing Zheng, Xiaochen Zhang, Jing Zhao, Yanping Zhu, Qian Shen, Yuehong Wang, Ke Sun, Zeying Zhang, Zhijie Pan, Yihong Shen, Jianying Zhou

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Sidedness and TP53 mutations impact OS in anti-EGFR but not anti-VEGF treated mCRC - an analysis of the KRAS registry of the AGMT (Arbeitsgemeinschaft Medikamentöse Tumortherapie)

Florian Huemer, Josef Thaler, Gudrun Piringer, Hubert Hackl, Lisa Pleyer, Clemens Hufnagl, Lukas Weiss, Richard Greil

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Analysis of microarrays of miR-34a and its identification of prospective target gene signature in hepatocellular carcinoma

Fang-Hui Ren, Hong Yang, Rong-quan He, Jing-ning Lu, Xing-gu Lin, Hai-Wei Liang, Yi-Wu Dang, Zhen-Bo Feng, Gang Chen, Dian-Zhong Luo

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

IMMUNEPOTENT CRP induces cell cycle arrest and caspase-independent regulated cell death in HeLa cells through reactive oxygen species production

Ana Carolina Martínez-Torres, Alejandra Reyes-Ruiz, Milena Benítez-Londoño, Moises Armides Franco-Molina, Cristina Rodríguez-Padilla

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Availability of anticancer medicines in public and private sectors, and their affordability by low, middle and high-income class patients in Pakistan

Muhammad Rehan Sarwar, Sadia Iftikhar, Anum Saqib

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Adjuvant stereotactic fractionated radiotherapy to the resection cavity in recurrent glioblastoma – the GlioCave study (NOA 17 – ARO 2016/3 – DKTK ROG trial)

Christoph Straube, Hagen Scherb, Jens Gempt, Jan Kirschke, Claus Zimmer, Friederike Schmidt-Graf, Bernhard Meyer, Stephanie E. Combs

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinomas harbouring BRCA1 and BRCA2 aberrations

Robert L. Hollis, Alison M. Meynert, Michael Churchman, Tzyvia Rye, Melanie Mackean, Fiona Nussey, Mark J. Arends, Andrew H. Sims, Colin A. Semple, C. Simon Herrington, Charlie Gourley

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Preoperative serum immunoglobulin G and A antibodies to Porphyromonas gingivalis are potential serum biomarkers for the diagnosis and prognosis of esophageal squamous cell carcinoma

She-Gan Gao, Jun-Qiang Yang, Zhi-Kun Ma, Xiang Yuan, Chen Zhao, Guang-Chao Wang, Hua Wei, Xiao-Shan Feng, Yi-Jun Qi

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

The Brainfit study: efficacy of cognitive training and exergaming in pediatric cancer survivors – a randomized controlled trial

Valentin Benzing, Noëmi Eggenberger, Janine Spitzhüttl, Valerie Siegwart, Manuela Pastore-Wapp, Claus Kiefer, Nedelina Slavova, Michael Grotzer, Theda Heinks, Mirko Schmidt, Achim Conzelmann, Maja Steinlin, Regula Everts, Kurt Leibundgut

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Development of the body image self-rating questionnaire for breast cancer (BISQ-BC) for Chinese mainland patients

Kaina Zhou, Xiaole He, Lanting Huo, Jinghua An, Minjie Li, Wen Wang, Xiaomei Li

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

Ildar V. Gainetdinov, Yulia V. Skvortsova, Sofia A. Kondratieva, Alexey Klimov, Alexey A. Tryakin, Tatyana L. Azhikina

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Testicular self examination among Bahir Dar University students: application of integrated behavioral model

Hordofa Gutema, Yamrot Debela, Bizuayehu Walle, Kidist Reba, Habtamu Wondiye

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The exploration of contrasting pathways in Triple Negative Breast Cancer (TNBC)

Shavira Narrandes, Shujun Huang, Leigh Murphy, Wayne Xu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Coordinated expression and genetic polymorphisms in Grainyhead-like genes in human non-melanoma skin cancers

Agnieszka Kikulska, Tobias Rausch, Ewa Krzywinska, Magdalena Pawlak, Bartek Wilczynski, Vladimir Benes, Piotr Rutkowski, Tomasz Wilanowski

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Nine primary malignant neoplasms-involving the esophagus, stomach, colon, rectum, prostate, and external ear canal-without microsatellite instability: a case report

Keiichi Arakawa, Keisuke Hata, Yoko Yamamoto, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Hiroaki Nozawa, Masafumi Yoshida, Hiroshi Fukuhara, Mitsuhiro Fujishiro, Teppei Morikawa, Tatsuya Yamasoba, Kazuhiko Koike, Masashi Fukayama, Toshiaki Watanabe

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Incidence, socioeconomic deprivation, volume-outcome and survival in adult patients with acute lymphoblastic leukaemia in England

Ravi Maheswaran, Nick Morley

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A quantitative multimodal metabolomic assay for colorectal cancer

Farshad Farshidfar, Karen A. Kopciuk, Robert Hilsden, S. Elizabeth McGregor, Vera C. Mazurak, W. Donald Buie, Anthony MacLean, Hans J. Vogel, Oliver F. Bathe

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells

Ting-ting Qu, Fei Chen, Jing Wang, Yan-jun Zhang, Mo-bin Cheng, Wen-zheng Sun, Yu-fei Shen, Ye Zhang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Optimising the chick chorioallantoic membrane xenograft model of neuroblastoma for drug delivery

Rasha Swadi, Grace Mather, Barry L. Pizer, Paul D. Losty, Violaine See, Diana Moss

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Using Resistin, glucose, age and BMI to predict the presence of breast cancer

Miguel Patrício, José Pereira, Joana Crisóstomo, Paulo Matafome, Manuel Gomes, Raquel Seiça, Francisco Caramelo

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Inhibition of neddylation facilitates cell migration through enhanced phosphorylation of caveolin-1 in PC3 and U373MG cells

Sung Yeon Park, Jong-Wan Park, Gun-Woo Lee, Lan Li, Yang-Sook Chun

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Evaluation of Endoglin (CD105) expression in pediatric rhabdomyosarcoma

Virginia Di Paolo, Ida Russo, Renata Boldrini, Lucilla Ravà, Marco Pezzullo, Maria Chiara Benedetti, Angela Galardi, Marta Colletti, Rossella Rota, Domenico Orlando, Alessandro Crocoli, Hector Peinado, Giuseppe Maria Milano, Angela Di Giannatale

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Evolutionary aspects of non-metastatic breast cancer after primary treatment in a sub-Saharan African setting: a 16-year retrospective review at the Douala general hospital, Cameroon

Bibiana Ateh Nzeangung, Martin Essomba Biwole, Benjamin Momo Kadia, Ndemazie Nkafu Bechem, Christian Akem Dimala, Albert Mouelle Sone

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comparison of cancer incidence in Australian farm residents 45 years and over, compared to rural non-farm and urban residents - a data linkage study

Julie Depczynski, Timothy Dobbins, Bruce Armstrong, Tony Lower

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

MiR-199a/b-3p inhibits gastric cancer cell proliferation via down-regulating PAK4/MEK/ERK signaling pathway

Bin Zeng, Wei Shi, Gao Tan

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

MLH1–93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation

Lochlan J. Fennell, Saara Jamieson, Diane McKeone, Tracie Corish, Megan Rohdmann, Tori Furner, Mark Bettington, Cheng Liu, Futoshi Kawamata, Catherine Bond, Jolieke Van De Pols, Barbara Leggett, Vicki Whitehall

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Regulation of pancreatic stellate cell activation by Notch3

Haiyan Song, Yuxiang Zhang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

High BCAR1 expression is associated with early PSA recurrence in ERG negative prostate cancer

Asmus Heumann, Nina Heinemann, Claudia Hube-Magg, Dagmar S. Lang, Katharina Grupp, Martina Kluth, Sarah Minner, Christina Möller-Koop, Markus Graefen, Hans Heinzer, Maria Christina Tsourlakis, Waldemar Wilczak, Corinna Wittmer, Frank Jacobsen, Hartwig Huland, Ronald Simon, Thorsten Schlomm, Guido Sauter, Stefan Steurer, Patrick Lebok, Andrea Hinsch

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Attributable causes of colorectal cancer in China

Meng-Jia Gu, Qiu-Chi Huang, Cheng-Zhen Bao, Ying-Jun Li, Xiao-Qin Li, Ding Ye, Zhen-Hua Ye, Kun Chen, Jian-Bing Wang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A novel lncRNA-focus expression signature for survival prediction in endometrial carcinoma

Meng Zhou, Zhaoyue Zhang, Hengqiang Zhao, Siqi Bao, Jie Sun

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A systematic review of clinic and community intervention to increase fecal testing for colorectal cancer in rural and low-income populations in the United States – How, what and when?

Melinda M. Davis, Michele Freeman, Jackilen Shannon, Gloria D. Coronado, Kurt C. Stange, Jeanne-Marie Guise, Stephanie B. Wheeler, David I. Buckley

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins

Carrie J. Lovitt, Todd B. Shelper, Vicky M. Avery

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Breast carcinoma with 21-gene recurrence score lower than 18: rate of locoregional recurrence in a large series with clinical follow-up

Gulisa Turashvili, Edi Brogi, Monica Morrow, Maura Dickler, Larry Norton, Clifford Hudis, Hannah Y. Wen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness

Charles S. Goldsmith, Sam Moon Kim, Nirmala Karunarathna, Nichole Neuendorff, L. Gerard Toussaint, David J. Earnest, Deborah Bell-Pedersen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Incidence of bone metastases in patients with solid tumors: analysis of oncology electronic medical records in the United States

Rohini K. Hernandez, Sally W. Wade, Adam Reich, Melissa Pirolli, Alexander Liede, Gary H. Lyman

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A train the trainer program for healthcare professionals tasked with providing psychosocial support to breast cancer survivors

Eunyoung Park, Junghee Yoon, Eun-kyung Choi, Im Ryung Kim, Danbee Kang, Se-Kyung Lee, Jeong Eon Lee, Seok Jin Nam, Jin Seok Ahn, Adriaan Visser, Juhee Cho

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer

Akhileshwar Namani, Md. Matiur Rahaman, Ming Chen, Xiuwen Tang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Mechanism of recipient cell-dependent differences in exosome uptake

Sayo Horibe, Toshihito Tanahashi, Shoji Kawauchi, Yoshiki Murakami, Yoshiyuki Rikitake

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Relationship between the extent of resection and the survival of patients with low-grade gliomas: a systematic review and meta-analysis

Liang Xia, Chenyan Fang, Gao Chen, Caixing Sun

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Stromal CD10 expression in breast cancer correlates with tumor invasion and cancer stem cell phenotype

Tahani Louhichi, Hanene Saad, Myriam Ben Dhiab, Sonia Ziadi, Mounir Trimeche

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A modified TNM staging system for non-metastatic colorectal cancer based on nomogram analysis of SEER database

Xiangxing Kong, Jun Li, Yibo Cai, Yu Tian, Shengqiang Chi, Danyang Tong, Yeting Hu, Qi Yang, Jingsong Li, Graeme Poston, Ying Yuan, Kefeng Ding

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Trastuzumab without chemotherapy in the adjuvant treatment of breast cancer: subgroup results from a large observational study

Peter Dall, Thorsten Koch, Thomas Göhler, Johannes Selbach, Andreas Ammon, Jochen Eggert, Nidal Gazawi, Daniela Rezek, Arthur Wischnik, Carsten Hielscher, Nicolas Schleif, Ursula Cirrincione, Axel Hinke, Gabriele Feisel-Schwickardi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Epoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway

Dhiraj Kumar, Saikat Haldar, Mahadeo Gorain, Santosh Kumar, Fayaj A. Mulani, Amit S. Yadav, Lucio Miele, Hirekodathakallu V. Thulasiram, Gopal C. Kundu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Moesin expression by tumor cells is an unfavorable prognostic biomarker for oral cancer

Francisco Bárbara Abreu Barros, Agnes Assao, Natália Galvão Garcia, Suely Nonogaki, André Lopes Carvalho, Fernando Augusto Soares, Luiz Paulo Kowalski, Denise Tostes Oliveira

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Health services research in patients with breast cancer (CAMISS-prospective): study protocol for an observational prospective study

Susana García-Gutierrez, Miren Orive, Cristina Sarasqueta, Maria Jose Legarreta, Nerea Gonzalez, Maximino Redondo, Amado Rivero, Pedro Serrano-Aguilar, Xavier Castells, Jose Maria Quintana, Maria Sala, on behalf of REDISSEC-CaMISS group

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

A randomized controlled trial of a skills training for oncologists and a communication aid for patients to stimulate shared decision making about palliative systemic treatment (CHOICE): study protocol

I. Henselmans, E. M. A. Smets, J. C. J. M. de Haes, M. G. W. Dijkgraaf, F. Y. de Vos, H. W. M. van Laarhoven

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Clinical and pathological factors influencing survival in a large cohort of triple-negative breast cancer patients

Silvana Anna Maria Urru, Silvano Gallus, Cristina Bosetti, Tiziana Moi, Ricardo Medda, Elisabetta Sollai, Alma Murgia, Francesca Sanges, Giovanna Pira, Alessandra Manca, Dolores Palmas, Matteo Floris, Anna Maria Asunis, Francesco Atzori, Ciriaco Carru, Maurizio D’Incalci, Massimo Ghiani, Vincenzo Marras, Daniela Onnis, Maria Cristina Santona, Giuseppina Sarobba, Enrichetta Valle, Luisa Canu, Sergio Cossu, Alessandro Bulfone, Paolo Cossu Rocca, Maria Rosaria De Miglio, Sandra Orrù

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Study protocol of a phase II clinical trial (KSCC1501A) examining oxaliplatin + S-1 for treatment of HER2-negative advanced/recurrent gastric cancer previously untreated with chemotherapy

Hiroshi Saeki, Yasunori Emi, Eiji Oki, Shoji Tokunaga, Yoshihiro Kakeji, Yoshito Akagi, Hideo Baba, Eishi Baba, Yoshihiko Maehara, Kyushu Study group of Clinical Cancer (KSCC)

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Ethnic disparities in breast cancer survival in New Zealand: which factors contribute?

Sandar Tin Tin, J. Mark Elwood, Charis Brown, Diana Sarfati, Ian Campbell, Nina Scott, Reena Ramsaroop, Sanjeewa Seneviratne, Vernon Harvey, Ross Lawrenson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Efficacy of a telephone outcall program to reduce caregiver burden among caregivers of cancer patients [PROTECT]: a randomised controlled trial

Leila Heckel, Kate M. Fennell, John Reynolds, Anna Boltong, Mari Botti, Richard H. Osborne, Cathrine Mihalopoulos, Jacquie Chirgwin, Melinda Williams, Cadeyrn J. Gaskin, David M. Ashley, Patricia M. Livingston

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

MGAT1 is a novel transcriptional target of Wnt/β-catenin signaling pathway

Izzet Akiva, Necla Birgül Iyison

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Serum miR-486-5p as a diagnostic marker in cervical cancer: with investigation of potential mechanisms

Chunmei Li, Xiaojiao Zheng, Wei Li, Fumao Bai, Jianxin Lyu, Qing H. Meng

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

The preventive effect of sensorimotor- and vibration exercises on the onset of Oxaliplatin- or vinca-alkaloid induced peripheral neuropathies - STOP

Fiona Streckmann, Maryam Balke, Helmar C. Lehmann, Vanessa Rustler, Christina Koliamitra, Thomas Elter, Michael Hallek, Michael Leitzmann, Tilman Steinmetz, Petra Heinen, Freerk T. Baumann, Wilhelm Bloch

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Staging laparoscopy for locally advanced gastric cancer in Chinese patients: a multicenter prospective registry study

Ziyu Li, Zhemin Li, Lianhai Zhang, Qian Liu, Zhenjun Wang, Zhongtao Zhang, Gang Xiao, Wei Fu, Xin Wang, Yingjiang Ye, Jianchun Yu, Fei Li, Lin Chen, Shibin Wang, Jiafu Ji

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Effects of concentrated long-chain omega-3 polyunsaturated fatty acid supplementation before radical prostatectomy on prostate cancer proliferation, inflammation, and quality of life: study protocol for a phase IIb, randomized, double-blind, placebo-controlled trial

Marie-Hélène Guertin, Karine Robitaille, Jean-François Pelletier, Thierry Duchesne, Pierre Julien, Josée Savard, Isabelle Bairati, Vincent Fradet

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Metformin, Asian ethnicity and risk of prostate cancer in type 2 diabetes: a systematic review and meta-analysis

Christopher B. Chen, Maxim Eskin, Dean T. Eurich, Sumit R. Majumdar, Jeffrey A. Johnson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The quality of working life questionnaire for cancer survivors (QWLQ-CS): factorial structure, internal consistency, construct validity and reproducibility

Merel de Jong, Sietske J. Tamminga, Robert J. J. van Es, Monique H. W. Frings-Dresen, Angela G. E. M. de Boer

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation

Nan Wu, Dong Ren, Su Li, Wenli Ma, Shaoyan Hu, Yan Jin, Sheng Xiao

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension

Ricardo Celestino, Torfinn Nome, Ana Pestana, Andreas M. Hoff, A. Pedro Gonçalves, Luísa Pereira, Bruno Cavadas, Catarina Eloy, Trine Bjøro, Manuel Sobrinho-Simões, Rolf I. Skotheim, Paula Soares

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation

Jeffrey J. Heard, Ivy Phung, Mark I. Potes, Fuyuhiko Tamanoi

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer

Xiao Wang, Jian Chen, Jingtao Wang, Fudong Yu, Senlin Zhao, Yu Zhang, Huamei Tang, Zhihai Peng

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effects of physical activity on colorectal cancer risk among family history and body mass index subgroups: a systematic review and meta-analysis

Eileen Shaw, Megan S. Farris, Chelsea R. Stone, Jeroen W. G. Derksen, Rhys Johnson, Robert J. Hilsden, Christine M. Friedenreich, Darren R. Brenner

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Adjuvant treatment of resectable biliary tract cancer with cisplatin plus gemcitabine: A prospective single center phase II study

Alexander R. Siebenhüner, Heike Seifert, Helga Bachmann, Burkhardt Seifert, Thomas Winder, Jonas Feilchenfeldt, Stefan Breitenstein, Pierre-Alain Clavien, Roger Stupp, Alexander Knuth, Bernhard Pestalozzi, Panagiotis Samaras

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effect of total number of harvested lymph nodes on survival outcomes after curative resection for gastric adenocarcinoma: findings from an eastern high-volume gastric cancer center

Shiela S. Macalindong, Kwang Hee Kim, Byung-Ho Nam, Keun Won Ryu, Norihito Kubo, Ja Yeon Kim, Bang Wool Eom, Hong Man Yoon, Myeong-Cherl Kook, Il Ju Choi, Young Woo Kim

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

MicroRNA-200a confers chemoresistance by antagonizing TP53INP1 and YAP1 in human breast cancer

San-Jian Yu, Liu Yang, Qi Hong, Xia-Ying Kuang, Gen-Hong Di, Zhi-Ming Shao

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prospective longitudinal quality of life and survival outcomes in patients with advanced infiltrative hepatocellular carcinoma and portal vein thrombosis treated with Yttrium-90 radioembolization

Minzhi Xing, Nima Kokabi, Juan C. Camacho, Hyun S. Kim

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Obesity and breast cancer outcomes in chemotherapy patients in New Zealand – a population-based cohort study

J. Mark Elwood, Sandar Tin Tin, Marion Kuper-Hommel, Ross Lawrenson, Ian Campbell

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Monitoring the responsiveness of T and antigen presenting cell compartments in breast cancer patients is useful to predict clinical tumor response to neoadjuvant chemotherapy

David A. Bernal-Estévez, Oscar García, Ramiro Sánchez, Carlos A. Parra-López

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Colorectal cancer liver metastases – a population-based study on incidence, management and survival

Jennie Engstrand, Henrik Nilsson, Cecilia Strömberg, Eduard Jonas, Jacob Freedman

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Treatment selection of early stage non-small cell lung cancer: the role of the patient in clinical decision making

S. Mokhles, J. J. M. E. Nuyttens, M. de Mol, J. G. J. V. Aerts, A. P. W. M. Maat, Ö. Birim, A. J. J. C. Bogers, J. J. M. Takkenberg

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: A systematic comparison of copy number alterations in four types of female cancer

Fatemeh Kaveh, Lars O. Baumbusch, Daniel Nebdal, Anne-Lise Børresen-Dale, Ole Christian Lingjærde, Hege Edvardsen, Vessela N. Kristensen, Hiroko K. Solvang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Additional dexamethasone in chemotherapies with carboplatin and paclitaxel could reduce the impaired glycometabolism in rat models

Yanxiu Guo, Haoxia Zeng, Xiaohong Chang, Chaohua Wang, Heng Cui

01.12.2018 | Technical advance | Ausgabe 1/2018 Open Access

Diagnostic accuracy and prediction increment of markers of epithelial-mesenchymal transition to assess cancer cell detachment from primary tumors

Evan L. Busch, Prabhani Kuruppumullage Don, Haitao Chu, David B. Richardson, Temitope O. Keku, David A. Eberhard, Christy L. Avery, Robert S. Sandler

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Variants of cancer susceptibility genes in Korean BRCA1/2 mutation-negative patients with high risk for hereditary breast cancer

Ji Soo Park, Seung-Tae Lee, Eun Ji Nam, Jung Woo Han, Jung-Yun Lee, Jieun Kim, Tae Il Kim, Hyung Seok Park

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cost-effectiveness of prostate cancer screening: a systematic review of decision-analytical models

Sabina Sanghera, Joanna Coast, Richard M. Martin, Jenny L. Donovan, Syed Mohiuddin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Somatic evolutionary timings of driver mutations

Karen Gomez, Sayaka Miura, Louise A. Huuki, Brianna S. Spell, Jeffrey P. Townsend, Sudhir Kumar

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

What is it about a cancer diagnosis that would worry people? A population-based survey of adults in England

Philippa J. Murphy, Laura A. V. Marlow, Jo Waller, Charlotte Vrinten

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer

Timothy O’Donnell, Elizabeth L. Christie, Arun Ahuja, Jacqueline Buros, B. Arman Aksoy, David D. L. Bowtell, Alexandra Snyder, Jeff Hammerbacher

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma

Guang-hua Xu, Ning Lou, Hang-chuan Shi, Yu-chen Xu, Hai-long Ruan, Wen Xiao, Lei Liu, Xiang Li, Hai-bing Xiao, Bin Qiu, Lin Bao, Chang-fei Yuan, Ya-li Zhou, Wen-jun Hu, Ke Chen, Hong-mei Yang, Xiao-ping Zhang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

AZGP1 inhibits soft tissue sarcoma cells invasion and migration

Jiayong Liu, Haibo Han, Zhengfu Fan, Marc El Beaino, Zhiwei Fang, Shu Li, Jiafu Ji

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

FAM3B/PANDER inhibits cell death and increases prostate tumor growth by modulating the expression of Bcl-2 and Bcl-XL cell survival genes

Paula Maciel-Silva, Izabela Caldeira, Icaro de Assis Santos, Ana Claudia Oliveira Carreira, Flavia Ramos Siqueira, Eliane Antonioli, Anna Carla Goldberg, José Ernesto Belizário, Humberto Miguel Garay-Malpartida

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Breast magnetic resonance imaging for surveillance of women with a personal history of breast cancer: outcomes stratified by interval between definitive surgery and surveillance MR imaging

Vivian Youngjean Park, Eun-Kyung Kim, Min Jung Kim, Hee Jung Moon, Jung Hyun Yoon

01.12.2018 | Gynäkologische Sarkome | Case report | Ausgabe 1/2018 Open Access

A remarkable response to pazopanib, despite recurrent liver toxicity, in a patient with a high grade endometrial stromal sarcoma, a case report

Arie J. Verschoor, Fabiënne A. R. M. Warmerdam, Tjalling Bosse, Judith V. M. G. Bovée, Hans Gelderblom

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Assessment of cancers’ diagnostic stage in a Deaf community - survey about 4363 Deaf patients recorded in French units

Vladimir Druel, Hélène Hayet, Laetitia Esman, Marie Clavel, Marie-Eve Rougé Bugat

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Testes-specific protease 50 (TSP50) promotes invasion and metastasis by inducing EMT in gastric cancer

Qing-Hua Cao, Fang Liu, Chang-Zhao Li, Ni Liu, Man Shu, Yuan Lin, Li Ding, Ling Xue

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Neuromyelitis optica spectrum disorder secondary to treatment with anti-PD-1 antibody nivolumab: the first report

Yoshitsugu Narumi, Ryohei Yoshida, Yoshinori Minami, Yasushi Yamamoto, Shiori Takeguchi, Kohei Kano, Kae Takahashi, Tsukasa Saito, Jun Sawada, Hiroya Terui, Takayuki Katayama, Takaaki Sasaki, Yoshinobu Ohsaki

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Shifting breast cancer surveillance from current hospital setting to a community based setting: a cost-effectiveness study

Kelly M. de Ligt, Annemieke Witteveen, Sabine Siesling, Lotte M. G. Steuten

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Efficacy of T-DM1 for leptomeningeal and brain metastases in a HER2 positive metastatic breast cancer patient: new directions for systemic therapy - a case report and literature review

Giuseppina Rosaria Rita Ricciardi, Alessandro Russo, Tindara Franchina, Silvia Schifano, Giampiero Mastroeni, Anna Santacaterina, Vincenzo Adamo

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

The PANDA study: a randomized phase II study of first-line FOLFOX plus panitumumab versus 5FU plus panitumumab in RAS and BRAF wild-type elderly metastatic colorectal cancer patients

Francesca Battaglin, Marta Schirripa, Federica Buggin, Filippo Pietrantonio, Federica Morano, Giorgia Boscolo, Giuseppe Tonini, Eufemia Stefania Lutrino, Jessica Lucchetti, Lisa Salvatore, Alessandro Passardi, Chiara Cremolini, Ermenegildo Arnoldi, Mario Scartozzi, Nicoletta Pella, Luca Boni, Francesca Bergamo, Vittorina Zagonel, Fotios Loupakis, Sara Lonardi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Leptin-induced ER-α-positive breast cancer cell viability and migration is mediated by suppressing CCN5-signaling via activating JAK/AKT/STAT-pathway

Inamul Haque, Arnab Ghosh, Seth Acup, Snigdha Banerjee, Kakali Dhar, Amitabha Ray, Sandipto Sarkar, Suman Kambhampati, Sushanta K. Banerjee

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma

Timothy Budden, Andre van der Westhuizen, Nikola A. Bowden

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Intra-arterial ethanol embolization augments response to TACE for treatment of HCC with portal venous tumor thrombus

Biao Yang, Chun-Lin Li, Wen-hao Guo, Tian-qiang Qin, He Jiao, Ze-jun Fei, Xuan Zhou, Lin-jia Duan, Zheng-yin Liao

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Variations of circulating cardiac biomarkers during and after anthracycline-containing chemotherapy in breast cancer patients

Pierre Frères, Nassim Bouznad, Laurence Servais, Claire Josse, Stéphane Wenric, Aurélie Poncin, Jérôme Thiry, Marie Moonen, Cécile Oury, Patrizio Lancellotti, Vincent Bours, Guy Jerusalem

01.12.2018 | Technical advance | Ausgabe 1/2018 Open Access

An advanced glioma cell invasion assay based on organotypic brain slice cultures

Tanja Eisemann, Barbara Costa, Jens Strelau, Michel Mittelbronn, Peter Angel, Heike Peterziel

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Vertebral fractures among breast cancer survivors in China: a cross-sectional study of prevalence and health services gaps

Evelyn Hsieh, Qin Wang, Renzhi Zhang, Xin Niu, Weibo Xia, Liana Fraenkel, Karl L. Insogna, Jing Li, Jennifer S. Smith, Chunwu Zhou, You-lin Qiao, Pin Zhang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Galectin-1 is a poor prognostic factor in patients with glioblastoma multiforme after radiotherapy

Shang-Yu Chou, Shao-Lun Yen, Chao-Cheng Huang, Eng-Yen Huang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Clinical management and outcome of patients with advanced NSCLC carrying EGFR mutations in Spain

Edurne Arriola, Ramón García Gómez, Pilar Diz, Margarita Majem, Maite Martínez Aguillo, Javier Valdivia, Alfredo Paredes, José Miguel Sánchez-Torres, Sergio Peralta Muñoz, Isidoro Barneto, Vanesa Gutierrez, Jesús Manuel Andrade Santiago, Francisco Aparisi, Dolores Isla, Santiago Ponce, David Vicente Baz, Angel Artal, Mariluz Amador, Mariano Provencio

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Genetic variation of the gene coding for microRNA-204 (miR-204) is a risk factor in acute myeloid leukaemia

Aleksandra Butrym, Piotr Łacina, Kazimierz Kuliczkowski, Katarzyna Bogunia-Kubik, Grzegorz Mazur

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Venous invasion as a risk factor for recurrence after gastrectomy followed by chemotherapy for stage III gastric cancer

Keiji Nishibeppu, Shuhei Komatsu, Daisuke Ichikawa, Taisuke Imamura, Toshiyuki Kosuga, Kazuma Okamoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Eigo Otsuji

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Evolution of quality of life in patients with breast cancer during the first year of follow-up in Morocco

B. M. Traore, S. El Fakir, H. Charaka, N. Benaicha, A. Najdi, A. Zidouh, M. Bennani, H. Errihani, N. Mellass, A. Benider, R. Bekkali, C. Nejjari

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Impact of new generation hormone-therapy on cognitive function in elderly patients treated for a metastatic prostate cancer: Cog-Pro trial protocol

Marie Lange, Heidi Laviec, Hélène Castel, Natacha Heutte, Alexandra Leconte, Isabelle Léger, Bénédicte Giffard, Aurélie Capel, Martine Dubois, Bénédicte Clarisse, Elodie Coquan, Frédéric Di Fiore, Sophie Gouérant, Philippe Bartélémy, Laure Pierard, Karim Fizazi, Florence Joly

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Cancer associated fibroblasts (CAFs) are activated in cutaneous basal cell carcinoma and in the peritumoural skin

Silje Haukali Omland, Erika Elgstrand Wettergren, Sarah Mollerup, Maria Asplund, Tobias Mourier, Anders Johannes Hansen, Robert Gniadecki

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prevalence of high-risk HPV genotypes, categorised by their quadrivalent and nine-valent HPV vaccination coverage, and the genotype association with high-grade lesions

María Paz-Zulueta, Ledicia Álvarez-Paredes, Juan Carlos Rodríguez Díaz, Paula Parás-Bravo, Ma. Encarnación Andrada Becerra, José María Rodríguez Ingelmo, María Montserrat Ruiz García, Joaquín Portilla, Miguel Santibañez

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Variant isoforms of CD44 involves acquisition of chemoresistance to cisplatin and has potential as a novel indicator for identifying a cisplatin-resistant population in urothelial cancer

Masayuki Hagiwara, Eiji Kikuchi, Nobuyuki Tanaka, Takeo Kosaka, Shuji Mikami, Hideyuki Saya, Mototsugu Oya

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Pretreatment quality of life as a predictor of survival for patients with nasopharyngeal carcinoma treated with IMRT

Shan-Shan Guo, Wen Hu, Qiu-Yan Chen, Jian-Mei Li, Shi-Heng Zhu, Yan He, Jia-Wen Li, Le Xia, Lu Ji, Cui-Ying Lin, Li-Ting Liu, Lin-Quan Tang, Ling Guo, Hao-Yuan Mo, Chong Zhao, Xiang Guo, Ka-Jia Cao, Chao-Nan Qian, Mu-Sheng Zeng, Ming-Huang Hong, Jian-Yong Shao, Ying Sun, Jun Ma, Yu-Ying Fan, Hai-Qiang Mai

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A statewide investigation of geographic lung cancer incidence patterns and radon exposure in a low-smoking population

Judy Y. Ou, Brynn Fowler, Qian Ding, Anne C. Kirchhoff, Lisa Pappas, Kenneth Boucher, Wallace Akerley, Yelena Wu, Kimberly Kaphingst, Garrett Harding, Deanna Kepka

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

An elevated expression of serum exosomal microRNA-191, − 21, −451a of pancreatic neoplasm is considered to be efficient diagnostic marker

Takuma Goto, Mikihiro Fujiya, Hiroaki Konishi, Junpei Sasajima, Shugo Fujibayashi, Akihiro Hayashi, Tatsuya Utsumi, Hiroki Sato, Takuya Iwama, Masami Ijiri, Aki Sakatani, Kazuyuki Tanaka, Yoshiki Nomura, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Yusuke Mizukami, Yutaka Kohgo, Toshikatsu Okumura

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Screening for immune-potentiating antigens from hepatocellular carcinoma patients after radiofrequency ablation by serum proteomic analysis

Shunli Shen, Hong Peng, Ye Wang, Ming Xu, Manxia Lin, Xiaoyan Xie, Baogang Peng, Ming Kuang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effect of neoadjuvant chemotherapy in patients with gastric cancer: a PRISMA-compliant systematic review and meta-analysis

Zhi-Feng Miao, Xing-Yu Liu, Zhen-Ning Wang, Ting-Ting Zhao, Ying-Ying Xu, Yong-Xi Song, Jin-Yu Huang, Hao Xu, Hui-Mian Xu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Longitudinal autoantibody responses against tumor-associated antigens decrease in breast cancer patients according to treatment modality

Rick L. Evans, James V. Pottala, Satoshi Nagata, Kristi A. Egland

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A retrospective study of the safety and efficacy of paclitaxel plus ramucirumab in patients with advanced or recurrent gastric cancer with ascites

Hiroshi Matsumoto, Akihito Kawazoe, Kaoru Shimada, Shota Fukuoka, Yasutoshi Kuboki, Hideaki Bando, Takashi Kojima, Atsushi Ohtsu, Takayuki Yoshino, Toshihiko Doi, Kohei Shitara

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Selective oestrogen receptor antagonists inhibit oesophageal cancer cell proliferation in vitro

Waleed Al-Khyatt, Cristina Tufarelli, Raheela Khan, Syed Yousef Iftikhar

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Phase I clinical study of brentuximab vedotin (SGN-35) involving children with recurrent or refractory CD30-positive Hodgkin’s lymphoma or systemic anaplastic large cell lymphoma: rationale, design and methods of BV-HLALCL study: study protocol

Masahiro Sekimizu, Akihiro Iguchi, Tetsuya Mori, Yuhki Koga, Akiko Kada, Akiko M. Saito, Keizo Horibe

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC): the crucial contribution of immune cells (effector, regulatory) and cytokines (Th1, Th2) to immune-mediated tumour cell death induced by NAC

Viriya Kaewkangsadan, Chandan Verma, Jennifer M. Eremin, Gerard Cowley, Mohammad Ilyas, Oleg Eremin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Screening for distress in patients with primary brain tumor using distress thermometer: a systematic review and meta-analysis

Fangkun Liu, Jing Huang, Liyang Zhang, Fan Fan, Jindong Chen, Kun Xia, Zhixiong Liu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A simple filter model to guide the allocation of healthcare resources for improving the treatment of depression among cancer patients

Robert W. Sanson-Fisher, Natasha E. Noble, Andrew M. Searles, Simon Deeming, Rochelle E. Smits, Christopher J. Oldmeadow, Jamie Bryant

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Trend analysis of the quality indicators for the Brazilian cervical cancer screening programme by region and state from 2006 to 2013

Ricardo Filipe Alves Costa, Adhemar Longatto-Filho, Fabiana de Lima Vazquez, Céline Pinheiro, Luiz Carlos Zeferino, José Humberto Tavares Guerreiro Fregnani

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Nc886 is epigenetically repressed in prostate cancer and acts as a tumor suppressor through the inhibition of cell growth

Rafael Sebastián Fort, Cecilia Mathó, Murilo Vieira Geraldo, María Carolina Ottati, Alex Shimura Yamashita, Kelly Cristina Saito, Katia Ramos Moreira Leite, Manuel Méndez, Noemí Maedo, Laura Méndez, Beatriz Garat, Edna Teruko Kimura, José Roberto Sotelo-Silveira, María Ana Duhagon

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Elevated systemic levels of the matrix metalloproteinase inhibitor TIMP-1 correlate with clinical markers of cachexia in patients with chronic pancreatitis and pancreatic cancer

Olga Prokopchuk, Barbara Grünwald, Ulrich Nitsche, Carsten Jäger, Oleksii L. Prokopchuk, Elaine C. Schubert, Helmut Friess, Marc E. Martignoni, Achim Krüger

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Analysis of tumour-infiltrating lymphocytes reveals two new biologically different subgroups of breast ductal carcinoma in situ

Marie Beguinot, Marie-Melanie Dauplat, Fabrice Kwiatkowski, Guillaume Lebouedec, Lucie Tixier, Christophe Pomel, Frederique Penault-Llorca, Nina Radosevic-Robin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Performance of a prognostic 31-gene expression profile in an independent cohort of 523 cutaneous melanoma patients

Jonathan S. Zager, Brian R. Gastman, Sancy Leachman, Rene C. Gonzalez, Martin D. Fleming, Laura K. Ferris, Jonhan Ho, Alexander R. Miller, Robert W. Cook, Kyle R. Covington, Kristen Meldi-Plasseraud, Brooke Middlebrook, Lewis H. Kaminester, Anthony Greisinger, Sarah I. Estrada, David M. Pariser, Lee D. Cranmer, Jane L. Messina, John T. Vetto, Jeffrey D. Wayne, Keith A. Delman, David H. Lawson, Pedram Gerami

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil

Manuel B. Braga-Neto, Jessica Gomes Carneiro, Alzira M. de Castro Barbosa, Igor S. Silva, Danielle C. Maia, Felipe S. Maciel, Rafael Jorge Alves de Alcântara, Paulo Roberto L. Vasconscelos, Lucia L. B. C. Braga

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Randomised controlled trial protocol (GRIP study): examining the effect of involvement of a general practitioner and home care oncology nurse after a cancer diagnosis on patient reported outcomes and healthcare utilization

I. A. A. Perfors, C. W. Helsper, E. A. Noteboom, E. van der Wall, N. J. de Wit, A. M. May

01.12.2018 | Software | Ausgabe 1/2018 Open Access

A web tool for designing and conducting phase I trials using the continual reassessment method

Nolan A. Wages, Gina R. Petroni

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review

Vincenzo Dario Mandato, Federica Torricelli, Valentina Mastrofilippo, Riccardo Valli, Lorenzo Aguzzoli, Giovanni Battista La Sala

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Treatment decisions, clinical outcomes, and pharmacoeconomics in the treatment of patients with EGFR mutated stage III/IV NSCLC in Germany: an observational study

Wolfgang Schuette, Peter Schirmacher, Wilfried E. E. Eberhardt, Manfred Dietel, Ute Zirrgiebel, Lars Muehlenhoff, Michael Thomas

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer

Peter J. Klauck, Stacey M. Bagby, Anna Capasso, Erica L. Bradshaw-Pierce, Heather M. Selby, Anna Spreafico, John J. Tentler, Aik Choon Tan, Jihye Kim, John J. Arcaroli, Alicia Purkey, Wells A. Messersmith, Keisuke Kuida, S. Gail Eckhardt, Todd M. Pitts

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Pre-operative and intra-operative detection of axillary lymph node metastases in 108 patients with invasive lobular breast cancer undergoing mastectomy

Jerica Novak, Nikola Besic, Radan Dzodic, Barbara Gazic, Andrej Vogrin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Changes in CT morphology can be an independent response marker for patients receiving regorafenib for colorectal liver metastases: retrospective pilot study

Yukinori Ozaki, Junichi Shindoh, Wataru Gonoi, Yujiro Nishioka, Chihiro Kondoh, Yuko Tanabe, Shuichiro Matoba, Hiroya Kuroyanagi, Masaji Hashimoto, Toshimi Takano

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

The FREGAT biobank: a clinico-biological database dedicated to esophageal and gastric cancers

Christophe Mariette, Florence Renaud, Guillaume Piessen, Patrick Gele, Marie-Christine Copin, Emmanuelle Leteurtre, Christine Delaeter, Malek Dib, Stéphanie Clisant, Valentin Harter, Franck Bonnetain, Alain Duhamel, Véronique Christophe, Antoine Adenis, Fregat Working Group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

CK1α overexpression correlates with poor survival in colorectal cancer

Julia Richter, Anna-Laura Kretz, Johannes Lemke, Michael Fauler, Jens-Uwe Werner, Stephan Paschke, Frank Leithäuser, Doris Henne-Bruns, Andreas Hillenbrand, Uwe Knippschild

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Whole blood microRNAs as potential biomarkers in post-operative early breast cancer patients

Marianna Alunni-Fabbroni, Leonie Majunke, Elisabeth K. Trapp, Marie Tzschaschel, Sven Mahner, Peter A. Fasching, Tanja Fehm, Andreas Schneeweiss, Thomas Beck, Ralf Lorenz, Thomas W. P. Friedl, Wolfgang Janni, Brigitte Rack, on behalf of the SUCCESS Study Group

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Neoadjuvant chemoradiotherapy plus surgery versus active surveillance for oesophageal cancer: a stepped-wedge cluster randomised trial

Bo Jan Noordman, Bas P. L. Wijnhoven, Sjoerd M. Lagarde, Jurjen J. Boonstra, Peter Paul L. O. Coene, Jan Willem T. Dekker, Michael Doukas, Ate van der Gaast, Joos Heisterkamp, Ewout A. Kouwenhoven, Grard A. P. Nieuwenhuijzen, Jean-Pierre E. N. Pierie, Camiel Rosman, Johanna W. van Sandick, Maurice J. C. van der Sangen, Meindert N. Sosef, Manon C. W. Spaander, Roelf Valkema, Edwin S. van der Zaag, Ewout W. Steyerberg, J. Jan B. van Lanschot, on behalf of the SANO-study group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

HtrA1 as a promising tissue marker in cancer: a meta-analysis

Emma Altobelli, Paolo Matteo Angeletti, Manrico Morroni, Valerio Filippo Profeta

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The potential predictive value of DEK expression for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer

J. Martinez-Useros, I. Moreno, M. J. Fernandez-Aceñero, M. Rodriguez-Remirez, A. Borrero-Palacios, A. Cebrian, T. Gomez del Pulgar, L. del Puerto-Nevado, W. Li, A. Puime-Otin, N. Perez, M. S. Soengas, J. Garcia-Foncillas

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Autoimmune comorbidities in patients with metastatic melanoma: a retrospective analysis of us claims data

Qiufei Ma, Mark Shilkrut, Zhongyun Zhao, Minming Li, Nicolas Batty, Beth Barber

01.12.2018 | Mammakarzinom | Case report | Ausgabe 1/2018 Open Access

It is no longer the time to disregard thyroid metastases from breast cancer: a case report and review of the literature

Matilde Pensabene, Brigida Stanzione, Ivana Cerillo, Giuseppe Ciancia, Immacolata Cozzolino, Raffaella Ruocco, Caterina Condello, Giuseppe Di Lorenzo, Mario Giuliano, Valeria Forestieri, Grazia Arpino, Sabino De Placido, Rossella Lauria

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A three-lncRNA signature predicts overall survival and disease-free survival in patients with esophageal squamous cell carcinoma

Guo-Wei Huang, Yu-Jie Xue, Zhi-Yong Wu, Xiu-E Xu, Jian-Yi Wu, Hui-Hui Cao, Ying Zhu, Jian-Zhong He, Chun-Quan Li, En-Min Li, Li-Yan Xu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Frequency of the acquired resistant mutation T790 M in non-small cell lung cancer patients with active exon 19Del and exon 21 L858R: a systematic review and meta-analysis

Zan-Feng Wang, Sheng-Xiang Ren, Wei Li, Guang-Hui Gao

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells

Chunwan Lu, Dafeng Yang, Maria E. Sabbatini, Aaron H. Colby, Mark W. Grinstaff, Nicholas H. Oberlies, Cedric Pearce, Kebin Liu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Arsenic trioxide attenuates STAT-3 activity and epithelial-mesenchymal transition through induction of SHP-1 in gastric cancer cells

Sung Ho Kim, Hyo Soon Yoo, Moon Kyung Joo, Taehyun Kim, Jong-Jae Park, Beom Jae Lee, Hoon Jai Chun, Sang Woo Lee, Young-Tae Bak

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Impact of body mass index on surgical outcomes of gastric cancer

Fan Feng, Gaozan Zheng, Xiaohua Guo, Zhen Liu, Guanghui Xu, Fei Wang, Qiao Wang, Man Guo, Xiao Lian, Hongwei Zhang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Germline BRCA1/BRCA2 mutations among high risk breast cancer patients in Jordan

Hikmat Abdel-Razeq, Amal Al-Omari, Farah Zahran, Banu Arun

01.12.2018 | Debate | Ausgabe 1/2018 Open Access

The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1)

Marthe-Susanna Wegner, Lisa Gruber, Peter Mattjus, Gerd Geisslinger, Sabine Grösch

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?

Suhas Vasaikar, Giorgos Tsipras, Natalia Landázuri, Helena Costa, Vanessa Wilhelmi, Patrick Scicluna, Huanhuan L. Cui, Abdul-Aleem Mohammad, Belghis Davoudi, Mingmei Shang, Sharan Ananthaseshan, Klas Strååt, Giuseppe Stragliotto, Afsar Rahbar, Kum Thong Wong, Jesper Tegner, Koon-Chu Yaiw, Cecilia Söderberg-Naucler

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Association of rs2282679 A>C polymorphism in vitamin D binding protein gene with colorectal cancer risk and survival: effect modification by dietary vitamin D intake

Yun Zhu, Peizhong Peter Wang, Guangju Zhai, Bharati Bapat, Sevtap Savas, Jennifer R. Woodrow, Peter T. Campbell, Yuming Li, Ning Yang, Xin Zhou, Elizabeth Dicks, John R. Mclaughlin, Patrick S. Parfrey

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

PD-L1 expression in malignant salivary gland tumors

Koji Harada, Tarannum Ferdous, Yoshiya Ueyama

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Diethylnitrosamine induces lung adenocarcinoma in FVB/N mouse

Zsolt Mervai, Krisztina Egedi, Ilona Kovalszky, Kornélia Baghy

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prognostic implications of polycomb proteins ezh2, suz12, and eed1 and histone modification by H3K27me3 in sarcoma

Yong Jin Cho, Soo Hee Kim, Eun Kyung Kim, Jung Woo Han, Kyoo-Ho Shin, Hyuk Hu, Kyung Sik Kim, Young Deuk Choi, Sunghoon Kim, Young Han Lee, Jin-Suck Suh, Joong Bae Ahn, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha, Sung-Taek Jung, Hyo Song Kim

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The effect of propofol and sevoflurane on cancer cell, natural killer cell, and cytotoxic T lymphocyte function in patients undergoing breast cancer surgery: an in vitro analysis

Jeong-Ae Lim, Chung-Sik Oh, Tae-Gyoon Yoon, Ji Yeon Lee, Seung-Hyun Lee, Young-Bum Yoo, Jung-Hyun Yang, Seong-Hyop Kim

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Smoking and prostate cancer: a life course analysis

Evelyn Jiménez-Mendoza, Ruth A. Vázquez-Salas, Tonatiuh Barrientos-Gutierrez, Luz Myriam Reynales-Shigematsu, Isaac Roberto Labra-Salgado, Hugo A. Manzanilla-García, Luisa E. Torres-Sánchez

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Trends in molecular subtypes of breast cancer: description of incidence rates between 2007 and 2012 from three French registries

Marion Cortet, Aurélie Bertaut, Florence Molinié, Simona Bara, Françoise Beltjens, Charles Coutant, Patrick Arveux

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Factors predicting patient satisfaction in women with advanced breast cancer: a prospective study

Wendy W. T. Lam, Ava Kwong, Dacita Suen, Janice Tsang, Inda Soong, Tze Kok Yau, Winnie Yeo, Joyce Suen, Wing Ming Ho, Ka Yan Wong, Wing Kin Sze, Alice W. Y. Ng, Richard Fielding

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Incidence and histological patterns of thyroid cancer in Sri Lanka 2001-2010: an analysis of national cancer registry data

Umesh Jayarajah, Ashan Fernando, Saumyakala Prabashani, Eshani A. Fernando, Sanjeewa A. Seneviratne

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells

Carlos M. Galmarini, Maud Martin, Benjamin Pierre Bouchet, María José Guillen-Navarro, Marta Martínez-Diez, Juan Fernando Martinez-Leal, Anna Akhmanova, Pablo Aviles

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Is RNASEL:p.Glu265* a modifier of early-onset breast cancer risk for carriers of high-risk mutations?

Tú Nguyen-Dumont, Zhi L. Teo, Fleur Hammet, Alexis Roberge, Maryam Mahmoodi, Helen Tsimiklis, Daniel J. Park, Bernard J. Pope, Andrew Lonie, Miroslav K. Kapuscinski, Khalid Mahmood, David E. Goldgar, Graham G. Giles, Ingrid Winship, John L. Hopper, Melissa C. Southey, ABCFR

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Assessing the performance of a Loop Mediated Isothermal Amplification (LAMP) assay for the detection and subtyping of high-risk suptypes of Human Papilloma Virus (HPV) for Oropharyngeal Squamous Cell Carcinoma (OPSCC) without DNA purification

Mitchell G. Rohatensky, Devon M. Livingstone, Paul Mintchev, Heather K. Barnes, Steven C. Nakoneshny, Douglas J. Demetrick, Joseph C. Dort, Guido van Marle

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM

Lina Mörén, Richard Perryman, Tim Crook, Julia K. Langer, Kevin Oneill, Nelofer Syed, Henrik Antti

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro

Ozlem Aslan, Mattia Cremona, Clare Morgan, Lydia W. Cheung, Gordon B. Mills, Bryan T. Hennessy

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Characteristics of people living in Italy after a cancer diagnosis in 2010 and projections to 2020

Stefano Guzzinati, Saverio Virdone, Roberta De Angelis, Chiara Panato, Carlotta Buzzoni, Riccardo Capocaccia, Silvia Francisci, Anna Gigli, Manuel Zorzi, Giovanna Tagliabue, Diego Serraino, Fabio Falcini, Claudia Casella, Antonio Giampiero Russo, Fabrizio Stracci, Bianca Caruso, Maria Michiara, Anna Luisa Caiazzo, Marine Castaing, Stefano Ferretti, Lucia Mangone, Giuseppa Rudisi, Flavio Sensi, Guido Mazzoleni, Fabio Pannozzo, Rosario Tumino, Mario Fusco, Paolo Ricci, Gemma Gola, Adriano Giacomin, Francesco Tisano, Giuseppa Candela, Anna Clara Fanetti, Filomena Pala, Antonella Sutera Sardo, Massimo Rugge, Laura Botta, Luigino Dal Maso

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prevalence of Mouse Mammary Tumor Virus (MMTV)-like sequences in human breast cancer tissues and adjacent normal breast tissues in Saudi Arabia

Reem Al Dossary, Khaled R. Alkharsah, Haitham Kussaibi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Factors associated with breast cancer recurrences or mortality and dynamic prediction of death using history of cancer recurrences: the French E3N cohort

Alexandre Lafourcade, Mathilde His, Laura Baglietto, Marie-Christine Boutron-Ruault, Laure Dossus, Virginie Rondeau

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comparison of first-line chemotherapy regimens for ovarian carcinosarcoma: a single institution case series and review of the literature

Melissa Brackmann, Marina Stasenko, Shitanshu Uppal, Jake Erba, R. Kevin Reynolds, Karen McLean

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case report

Min-joo Ahn, Kanghan Lee, Kyung Hwa Lee, Jin Woong Kim, In-Young Kim, Woo Kyun Bae

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)

Una Kjällquist, Rikard Erlandsson, Nicholas P. Tobin, Amjad Alkodsi, Ikram Ullah, Gustav Stålhammar, Eva Karlsson, Thomas Hatschek, Johan Hartman, Sten Linnarsson, Jonas Bergh

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

NBS1 rs2735383 polymorphism is associated with an increased risk of laryngeal carcinoma

Xinmei Hu, Juan Liao, Huiliu Zhao, Feng Chen, Xuefeng Zhu, Jiangheng Li, Qingqing Nong

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prognostic impact of presumed breast or ovarian cancer among patients with unfavorable-subset cancer of unknown primary site

Makoto Kodaira, Kan Yonemori, Tatsunori Shimoi, Akihiko Yoshida, Masayuki Yoshida, Atsuko Kitano, Akihiko Shimomura, Mayu Yunokawa, Chikako Shimizu, Yuichi Takiguchi, Yasuhiro Fujiwara, Kenji Tamura

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

High-dose thiotepa-related neurotoxicity and the role of tramadol in children

Christophe Maritaz, Francois Lemare, Agnes Laplanche, Sylvie Demirdjian, Dominique Valteau-Couanet, Christelle Dufour

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Real-life feasibility of home-based pulmonary rehabilitation in chemotherapy-treated patients with thoracic cancers: a pilot study

Cecile Olivier, Jean-Marie Grosbois, Alexis B. Cortot, Sophie Peres, Christophe Heron, Julie Delourme, Marianne Gierczynski, Anne Hoorelbeke, Arnaud Scherpereel, Olivier Le Rouzic

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Male BRCA mutation carriers: clinical characteristics and cancer spectrum

Mohammed Ibrahim, Siddhartha Yadav, Foluso Ogunleye, Dana Zakalik

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Genetic determinants of sporadic breast cancer in Sri Lankan women

Nirmala Dushyanthi Sirisena, Adebowale Adeyemo, Anchala I. Kuruppu, Nilaksha Neththikumara, Nilakshi Samaranayake, Vajira H. W. Dissanayake

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Serum and blood based biomarkers for lung cancer screening: a systematic review

Gavin C. W. Chu, Kim Lazare, Frank Sullivan

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A novel miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry contributes to leukemogenesis in acute myeloid leukemia

Laixi Bi, Bin Zhou, Haiying Li, Licai He, Chunjing Wang, Zhonggai Wang, Liqing Zhu, Mengqian Chen, Shenmeng Gao

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

HIPECT4: multicentre, randomized clinical trial to evaluate safety and efficacy of Hyperthermic intra-peritoneal chemotherapy (HIPEC) with Mitomycin C used during surgery for treatment of locally advanced colorectal carcinoma

A. Arjona-Sánchez, P. Barrios, E. Boldo-Roda, B. Camps, J. Carrasco-Campos, V. Concepción Martín, A. García-Fadrique, A. Gutiérrez-Calvo, R. Morales, G. Ortega-Pérez, E. Pérez-Viejo, A. Prada-Villaverde, J. Torres-Melero, E. Vicente, P. Villarejo-Campos, J. M. Sánchez-Hidalgo, A. Casado-Adam, Ruben García-Martin, Manuel Medina, T. Caro, C. Villar, Enrique Aranda, M. T. Cano-Osuna, C. Díaz-López, E. Torres-Tordera, F. J. Briceño-Delgado, S. Rufián-Peña

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study

Masanori Nojima, Motoki Iwasaki, Yoshio Kasuga, Shiro Yokoyama, Hiroshi Onuma, Hideki Nishimura, Ritsu Kusama, Teruhiko Yoshida, Shoichiro Tsugane

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Impact of PKCε downregulation on autophagy in glioblastoma cells

Ewa Toton, Aleksandra Romaniuk, Natalia Konieczna, Johann Hofmann, Jan Barciszewski, Maria Rybczynska

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Treatment using oxaliplatin and S-1 adjuvant chemotherapy for pathological stage III gastric cancer: a multicenter phase II study (TOSA trial) protocol

Tsutomu Namikawa, Hiromichi Maeda, Hiroyuki Kitagawa, Koji Oba, Akihito Tsuji, Takaki Yoshikawa, Michiya Kobayashi, Kazuhiro Hanazaki

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Phase I study of an active immunotherapy for asymptomatic phase Lymphoplasmacytic lymphoma with DNA vaccines encoding antigen-chemokine fusion: study protocol

Sheeba K. Thomas, Soung-chul Cha, D. Lynne Smith, Kun Hwa Kim, Sapna R. Parshottam, Sheetal Rao, Michael Popescu, Vincent Y. Lee, Sattva S. Neelapu, Larry W. Kwak

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Transarterial chemoembolization (TACE) using mitomycin and lipiodol with or without degradable starch microspheres for hepatocellular carcinoma: comparative study

Tatjana Gruber-Rouh, Cornelia Schmitt, Nagy N. N. Naguib, N. A. Nour-Eldin, Katrin Eichler, Martin Beeres, Thomas J. Vogl

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Physical activity and risk of testicular cancer: a systematic review

Stephanie Huang, Virginia Signal, Diana Sarfati, Caroline Shaw, James Stanley, Katherine McGlynn, Jason Gurney

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Lack of association between cigarette smoking and Epstein Barr virus reactivation in the nasopharynx in people with elevated EBV IgA antibody titres

Yufeng Chen, Yifei Xu, Weilin Zhao, Xue Xiao, Xiaoying Zhou, Longde Lin, Tingting Huang, Jian Liao, Yancheng Li, Xiaoyun Zeng, Guangwu Huang, Weimin Ye, Zhe Zhang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The T790M resistance mutation in EGFR is only found in cfDNA from erlotinib-treated NSCLC patients that harbored an activating EGFR mutation before treatment

Christina Demuth, Anne Tranberg Madsen, Britta Weber, Lin Wu, Peter Meldgaard, Boe Sandahl Sorensen

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Fertility preservation healthcare circuit and networks in cancer patients worldwide: what are the issues?

Kathleen Melan, Frederic Amant, Jacqueline Veronique-Baudin, Clarisse Joachim, Eustase Janky

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

In vitro and in silico validation of CA3 and FHL1 downregulation in oral cancer

Cláudia Maria Pereira, Ana Carolina de Carvalho, Felipe Rodrigues da Silva, Matias Eliseo Melendez, Roberta Cardim Lessa, Valéria Cristina C. Andrade, Luiz Paulo Kowalski, André L. Vettore, André Lopes Carvalho

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Safety and efficacy of temsirolimus as second line treatment for patients with recurrent bladder cancer

Marina Pulido, Guilhem Roubaud, Anne-Laure Cazeau, Hakim Mahammedi, Lionel Vedrine, Florence Joly, Loic Mourey, Christian Pfister, Alejandro Goberna, Barbara Lortal, Carine Bellera, Philippe Pourquier, Nadine Houédé

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

RECORD-4 multicenter phase 2 trial of second-line everolimus in patients with metastatic renal cell carcinoma: Asian versus non-Asian population subanalysis

Lin Yang, Anna Alyasova, Dingwei Ye, Antonia Ridolfi, Luca Dezzani, Robert J. Motzer

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Treatment of upper tract urothelial carcinoma with ureteroscopy and thulium laser: a retrospective single center study

Jin Wen, Zhi G. Ji, Han Z. Li

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Radiotherapy related skin toxicity (RAREST-01): Mepitel® film versus standard care in patients with locally advanced head-and-neck cancer

Carlos Narvaez, Claudia Doemer, Christian Idel, Cornelia Setter, Denise Olbrich, Zaza Ujmajuridze, Jesper Hansen Carl, Dirk Rades

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Oxidative damage and response to Bacillus Calmette-Guérin in bladder cancer cells expressing sialyltransferase ST3GAL1

Paulo F. Severino, Mariana Silva, Mylene Carrascal, Nadia Malagolini, Mariella Chiricolo, Giulia Venturi, Roberto Barbaro Forleo, Annalisa Astolfi, Mariangela Catera, Paula A. Videira, Fabio Dall’Olio

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A prospective study to investigate the role of serial serum mesothelin in monitoring mesothelioma

Duneesha de Fonseka, David T. Arnold, Louise Stadon, Anna Morley, Emma Keenan, Michael Darby, Lynne Armstrong, Paul Virgo, Nick A. Maskell

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression

Zhikun Liu, Jie Li, Jun Chen, Qiaonan Shan, Haojiang Dai, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Association of differential miRNA expression with hepatic vs. peritoneal metastatic spread in colorectal cancer

Sabine Heublein, Markus Albertsmeier, David Pfeifer, Lisa Loehrs, Alexandr V. Bazhin, Thomas Kirchner, Jens Werner, Jens Neumann, Martin Kurt Angele

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Metastatic cardiac tumors: from clinical presentation through diagnosis to treatment

Ivana Burazor, Sarit Aviel-Ronen, Massimo Imazio, Orly Goitein, Marina Perelman, Natalia Shelestovich, Ninoslav Radovanovic, Vladimir Kanjuh, Iris Barshack, Yehuda Adler

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options

Peter F. McAnena, Andrew McGuire, A. Ramli, C. Curran, C. Malone, R. McLaughlin, K. Barry, James A.L. Brown, M. J. Kerin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Filtration based assessment of CTCs and CellSearch® based assessment are both powerful predictors of prognosis for metastatic breast cancer patients

Hanna Huebner, Peter A. Fasching, Walter Gumbrecht, Sebastian Jud, Claudia Rauh, Mark Matzas, Peter Paulicka, Katja Friedrich, Michael P. Lux, Bernhard Volz, Paul Gass, Lothar Häberle, Franziska Meier-Stiegen, Andreas Hartkopf, Hans Neubauer, Katrin Almstedt, Matthias W. Beckmann, Tanja N. Fehm, Matthias Ruebner

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Glucose, lipids and gamma-glutamyl transferase measured before prostate cancer diagnosis and secondly diagnosed primary tumours: a prospective study in the Swedish AMORIS cohort

Cecilia Bosco, Hans Garmo, Niklas Hammar, Göran Walldius, Ingmar Jungner, Håkan Malmström, Lars Holmberg, Mieke Van Hemelrijck

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Rapid symptomatic relief of HER2-positive gastric cancer leptomeningeal carcinomatosis with lapatinib, trastuzumab and capecitabine: a case report

Xiao-Dong Jiao, Chunming Ding, Yuan-Sheng Zang, Guanzhen Yu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Glycolysis is essential for chemoresistance induced by transient receptor potential channel C5 in colorectal cancer

Teng Wang, Kuan Ning, Xu Sun, Chun Zhang, Lin-fang Jin, Dong Hua

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Determinants of cancer screening awareness and participation among Indonesian women

Sumadi L. Anwar, Gindo Tampubolon, Mieke Van Hemelrijck, Susanna H. Hutajulu, Johnathan Watkins, Wahyu Wulaningsih, for the PILAR Research Network

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Evaluating different breast tumor progression models using screening data

Åsbjørn Schumacher Westvik, Harald Weedon-Fekjær, Jan Mæhlen, Knut Liestøl

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy

Antoni Domagala, Joanna Stachura, Magdalena Gabrysiak, Angelika Muchowicz, Radoslaw Zagozdzon, Jakub Golab, Malgorzata Firczuk

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Preliminary qualification of a novel, hypoxic-based radiologic signature for trans-arterial chemoembolization in hepatocellular carcinoma

David J. Pinato, Madhava Pai, Isabella Reccia, Markand Patel, Alexandros Giakoustidis, Georgios Karamanakos, Azelea Rushd, Shiraz Jamshaid, Alberto Oldani, Glenda Grossi, Mario Pirisi, Paul Tait, Rohini Sharma

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Successful treatment with pazopanib plus PD-1 inhibitor and RAK cells for advanced primary hepatic angiosarcoma: a case report

Yu Qiao, Jihong Yang, Lili Liu, Yixin Zeng, Jie Ma, Jing Jia, Li Zhang, Xiaoguang Li, Peihong Wu, Wenchao Wang, Dongge Liu, Huan Chen, Yunbo Zhao, Huan Xi, Yao Wang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients

Marek Kowalczyk, Marcin Orłowski, Piotr Siermontowski, Dariusz Mucha, Krzysztof Zinkiewicz, Waldemar Kurpiewski, Ewa Zieliński, Iwona Kowalczyk, Agnieszka Pedrycz

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Real life patterns of care and progression free survival in metastatic renal cell carcinoma patients: retrospective analysis of cross-sectional data

Rana Maroun, Laura Mitrofan, Laure Benjamin, Gaelle Nachbaur, Franck Maunoury, Philippe Le Jeunne, Isabelle Durand-Zaleski

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Structural and advanced imaging in predicting MGMT promoter methylation of primary glioblastoma: a region of interest based analysis

Yu Han, Lin-Feng Yan, Xi-Bin Wang, Ying-Zhi Sun, Xin Zhang, Zhi-Cheng Liu, Hai-Yan Nan, Yu-Chuan Hu, Yang Yang, Jin Zhang, Ying Yu, Qian Sun, Qiang Tian, Bo Hu, Gang Xiao, Wen Wang, Guang-Bin Cui

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A novel combined systemic inflammation-based score can predict survival of intermediate-to-advanced hepatocellular carcinoma patients undergoing transarterial chemoembolization

Chang Liu, Lei Li, Wu-sheng Lu, Hua Du, Lu-nan Yan, Tian-fu Wen, Wu-ran Wei, Li Jiang, Ming-qing Xu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells

Eleanor M. O’Brien, Joanna L. Selfe, Ana Sofia Martins, Zoë S. Walters, Janet M. Shipley

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

A randomised trial to compare cognitive outcome after gamma knife radiosurgery versus whole brain radiation therapy in patients with multiple brain metastases: research protocol CAR-study B

Wietske C. M. Schimmel, Eline Verhaak, Patrick E. J. Hanssens, Karin Gehring, Margriet M. Sitskoorn

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

LGR5 overexpression confers poor relapse-free survival in breast cancer patients

Ming-Feng Hou, Po-Ming Chen, Pei-Yi Chu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Body mass index and lung cancer risk: a pooled analysis based on nested case-control studies from four cohort studies

Harinakshi Sanikini, Jian-Min Yuan, Lesley M. Butler, Woon-Puay Koh, Yu-Tang Gao, Annika Steffen, Mattias Johansson, Paolo Vineis, Gary E. Goodman, Matt J. Barnett, Rayjean J. Hung, Chu Chen, Isabelle Stücker

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Gap junctions contribute to anchorage-independent clustering of breast cancer cells

Fabien Gava, Lise Rigal, Odile Mondesert, Elise Pesce, Bernard Ducommun, Valérie Lobjois

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Microenvironment dependent gene expression signatures in reprogrammed human colon normal and cancer cell lines

Egle Strainiene, Mindaugas Binkis, Silvija Urnikyte, Vaidotas Stankevicius, Ausra Sasnauskiene, Gabrielis Kundrotas, Andrius Kazlauskas, Kestutis Suziedelis

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

High-level cytoplasmic claudin 3 expression is an independent predictor of poor survival in triple-negative breast cancer

Anniina Jääskeläinen, Ylermi Soini, Arja Jukkola-Vuorinen, Päivi Auvinen, Kirsi-Maria Haapasaari, Peeter Karihtala

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors

Heleen K. Bronsveld, Marie L. De Bruin, Jelle Wesseling, Joyce Sanders, Ingrid Hofland, Vibeke Jensen, Marloes T. Bazelier, Bas ter Braak, Anthonius de Boer, Peter Vestergaard, Marjanka K. Schmidt

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy

Kim A. Brogden, Deepak Parashar, Andrea R. Hallier, Terry Braun, Fang Qian, Naiyer A. Rizvi, Aaron D. Bossler, Mohammed M. Milhem, Timothy A. Chan, Taher Abbasi, Shireen Vali

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Centralising specialist cancer surgery services in England: survey of factors that matter to patients and carers and health professionals

Mariya Melnychuk, Cecilia Vindrola-Padros, Michael Aitchison, Caroline S. Clarke, Naomi J. Fulop, Claire Levermore, Satish B. Maddineni, Caroline M. Moore, Muntzer M. Mughal, Catherine Perry, Kathy Pritchard-Jones, Angus I. G. Ramsay, David Shackley, Jonathan Vickers, Stephen Morris

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Positive expression of Midkine predicts early recurrence and poor prognosis of initially resectable combined hepatocellular cholangiocarcinoma

Ming-Chun Ma, Yi-Ju Chen, Tai-Jan Chiu, Jui Lan, Chien-Ting Liu, Yi-Ching Chen, Hsin-Ho Tien, Yen-Yang Chen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Low-dose aspirin use and survival in colorectal cancer: results from a population-based cohort study

Ronan T. Gray, Helen G. Coleman, Carmel Hughes, Liam J. Murray, Chris R. Cardwell

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Development and evaluation of a risk assessment tool to improve clinical triage accuracy for colonoscopic investigations

Anton R. Lord, Lisa A. Simms, Allison Brown, Katherine Hanigan, Krupa Krishnaprasad, Belinda Schouten, Anthony R. Croft, Mark N. Appleyard, Graham L. Radford-Smith

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Stellate cells and mesenchymal stem cells in benign mammary stroma are associated with risk factors for breast cancer – an observational study

Björn Logi Isfoss, Bo Holmqvist, Elin Sand, Johan Forsell, Helena Jernström, Håkan Olsson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Compound A attenuates toll-like receptor 4-mediated paclitaxel resistance in breast cancer and melanoma through suppression of IL-8

Rochanawan Sootichote, Peti Thuwajit, Ekapot Singsuksawat, Malee Warnnissorn, Pa-thai Yenchitsomanus, Suthinee Ithimakin, Jomjit Chantharasamee, Chanitra Thuwajit

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Palliative external beam radiotherapy for the treatment of tumor bleeding in inoperable advanced gastric cancer

Yun Hee Lee, Jeong Won Lee, Hong Seok Jang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Dairy products and colorectal cancer in middle eastern and north African countries: a systematic review

K. El kinany, M. Deoula, Z. Hatime, B. Bennani, K. El Rhazi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Impact of timing of adjuvant chemotherapy on survival in stage III colon cancer: a population-based study

Peng Gao, Xuan-zhang Huang, Yong-xi Song, Jing-xu Sun, Xiao-wan Chen, Yu Sun, Yu-meng Jiang, Zhen-ning Wang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effect of surgery and radiotherapy on complete blood count, lymphocyte subsets and inflammatory response in patients with advanced oral cancer

Tadej Dovšak, Alojz Ihan, Vojko Didanovič, Andrej Kansky, Miha Verdenik, Nataša Ihan Hren

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comparative oesophageal cancer risk assessment of hot beverage consumption (coffee, mate and tea): the margin of exposure of PAH vs very hot temperatures

Alex O. Okaru, Anke Rullmann, Adriana Farah, Elvira Gonzalez de Mejia, Mariana C. Stern, Dirk W. Lachenmeier

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies

Marilia Takada, Maciej Parys, Emmalena Gregory-Bryson, Paulo Vilar Saavedra, Matti Kiupel, Vilma Yuzbasiyan-Gurkan

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2

Hamid Maadi, Babak Nami, Junfeng Tong, Gina Li, Zhixiang Wang

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Clinical decision making in the era of immunotherapy for high grade-glioma: report of four cases

Surabhi Ranjan, Martha Quezado, Nancy Garren, Lisa Boris, Christine Siegel, Osorio Lopes Abath Neto, Brett J. Theeler, Deric M. Park, Edjah Nduom, Kareem A. Zaghloul, Mark R. Gilbert, Jing Wu

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Oncology practitioners’ perspectives and practice patterns of post-treatment cancer survivorship care in the Asia-Pacific region: results from the STEP study

Raymond Javan Chan, Patsy Yates, Qiuping Li, Hiroko Komatsu, Violeta Lopez, Myat Thandar, Selva Titus Chacko, Winnie Kwok Wei So, Kanaungnit Pongthavornkamol, Myungsun Yi, Pongpak Pittayapan, Jesson Butcon, David Wyld, Alex Molassiotis, on behalf of the STEP study collaborators

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Phase II study of bevacizumab, cisplatin, and docetaxel plus maintenance bevacizumab as first-line treatment for patients with advanced non-squamous non-small-cell lung cancer combined with exploratory analysis of circulating endothelial cells: Thoracic Oncology Research Group (TORG)1016

Satoshi Ikeda, Terufumi Kato, Takashi Ogura, Akimasa Sekine, Tsuneyuki Oda, Noriyuki Masuda, Satoshi Igawa, Ken Katono, Sakiko Otani, Kouzo Yamada, Haruhiro Saito, Tetsuro Kondo, Yukio Hosomi, Yoshiro Nakahara, Masanori Nishikawa, Keiko Utumi, Yuki Misumi, Takeharu Yamanaka, Kentaro Sakamaki, Hiroaki Okamoto

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Patients’ experiences of diagnosis and management of papillary thyroid microcarcinoma: a qualitative study

Brooke Nickel, Juan P. Brito, Ray Moynihan, Alexandra Barratt, Susan Jordan, Kirsten McCaffery

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

High CD8+ and absence of Foxp3+ T lymphocytes infiltration in gallbladder tumors correlate with prolonged patients survival

Paula Fluxá, Daniel Rojas-Sepúlveda, María Alejandra Gleisner, Andrés Tittarelli, Pablo Villegas, Loreto Tapia, María Teresa Rivera, Mercedes Natalia López, Felipe Catán, Mario Uribe, Flavio Salazar-Onfray

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Feasibility, useability and acceptability of technology-based interventions for informal cancer carers: a systematic review

Natalie Heynsbergh, Leila Heckel, Mari Botti, Patricia M. Livingston

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

New paste for severe stomatitis in patients undergoing head-and-neck cancer radiotherapy and/or chemotherapy with oral appliance

Ayumi Sakuramoto, Yoko Hasegawa, Kazuma Sugahara, Yoshiyuki Komoda, Kana Hasegawa, Shinichi Hikasa, Mai Kurashita, Junya Sakai, Masahiro Arita, Kazuhiro Yasukawa, Hiromitsu Kishimoto

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Systematic reviews and cancer research: a suggested stepwise approach

George A. Kelley, Kristi S. Kelley

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Safety assessment of sorafenib in Chinese patients with unresectable hepatocellular carcinoma: subgroup analysis of the GIDEON study

Sheng-Long Ye, Jiamei Yang, Ping Bie, Shuijun Zhang, Xiaoping Chen, Fengyong Liu, Luming Liu, Jie Zhou, Kefeng Dou, Chunyi Hao, Guoliang Shao, Qiang Xia, Yajin Chen, Jijin Yang, Xiaxing Deng, Yunpeng Liu, Yunfei Yuan, Zhiren Fu, Keiko Nakajima, Zhengguang Lv

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Identification of novel enriched recurrent chimeric COL7A1-UCN2 in human laryngeal cancer samples using deep sequencing

Ye Tao, Neil Gross, Xiaojiao Fan, Jianming Yang, Maikun Teng, Xu Li, Guojun Li, Yang Zhang, Zhigang Huang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity

Sanja Brolih, Scott K. Parks, Valérie Vial, Jérôme Durivault, Livio Mostosi, Jacques Pouysségur, Gilles Pagès, Vincent Picco

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Threat of biographical disruption: the gendered construction and experience of infertility following cancer for women and men

Jane M. Ussher, Janette Perz, The Australian Cancer and Fertility Study Team (ACFST)

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma

Hongyang Lu, Shifeng Yang, Huineng Zhu, Xiaoling Tong, Fajun Xie, Jing Qin, Na Han, Xue Wu, Yun Fan, Yang W. Shao, Weimin Mao

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A phase II trial of S-1 and oxaliplatin in patients with advanced hepatocellular carcinoma

Dae-Won Lee, Kyung-Hun Lee, Hee-Jun Kim, Tae-Yong Kim, Jin-Soo Kim, Sae-Won Han, Do-Youn Oh, Jee Hyun Kim, Seock-Ah Im, Tae-You Kim

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Mixed response on regorafenib treatment for GIST (gastro-intestinal stromal tumor) according to 18F–FDG-PET/CT

Donatienne Van Weehaeghe, Olivier Gheysens, Vincent Vandecaveye, Patrick Schöffski, Koen Van Laere, Christophe M. Deroose

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A population-based analysis of germline BRCA1 and BRCA2 testing among ovarian cancer patients in an era of histotype-specific approaches to ovarian cancer prevention

Gillian E. Hanley, Jessica N. McAlpine, Dianne Miller, David Huntsman, Kasmintan A. Schrader, C. Blake Gilks, Gillian Mitchell

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

ATF-3/miR-590/GOLPH3 signaling pathway regulates proliferation of breast cancer

Qiong Song, Qiu Chen, Qimin Wang, Longqiu Yang, Dongdong Lv, Guangli Jin, Jiaying Liu, Baolin Li, Xuejie Fei

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Detection and interval cancer rates during the transition from screen-film to digital mammography in population-based screening

Valérie D. V. Sankatsing, Jacques Fracheboud, Linda de Munck, Mireille J. M. Broeders, Nicolien T. van Ravesteyn, Eveline A. M. Heijnsdijk, André L. M. Verbeek, Johannes D. M. Otten, Ruud M. Pijnappel, Sabine Siesling, Harry J. de Koning, National Evaluation Team for Breast cancer screening, NETB

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Case report: 8 years after liver transplantation: de novo hepatocellular carcinoma 8 months after HCV clearance through IFN-free antiviral therapy

Giuliano Ramadori, Patrizia Bosio, Federico Moriconi, Ihtzaz A. Malik

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Temporal and geographic variation in the systemic treatment of advanced prostate cancer

Megan E. V. Caram, Jason P. Estes, Jennifer J. Griggs, Paul Lin, Bhramar Mukherjee

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Signaling protein signature predicts clinical outcome of non-small-cell lung cancer

Bao-Feng Jin, Fan Yang, Xiao-Min Ying, Lin Gong, Shuo-Feng Hu, Qing Zhao, Yi-Da Liao, Ke-Zhong Chen, Teng Li, Yan-Hong Tai, Yuan Cao, Xiao Li, Yan Huang, Xiao-Yan Zhan, Xuan-He Qin, Jin Wu, Shuai Chen, Sai-Sai Guo, Yu-Cheng Zhang, Jing Chen, Dan-Hua Shen, Kun-Kun Sun, Lu Chen, Wei-Hua Li, Ai-Ling Li, Na Wang, Qing Xia, Jun Wang, Tao Zhou

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

TIPE3 differentially modulates proliferation and migration of human non-small-cell lung cancer cells via distinct subcellular location

Guannan Wang, Chun Guo, Hui Zhao, Zhenzhen Pan, Faliang Zhu, Lining Zhang, Qun Wang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Quality assurance target for community-based breast cancer screening in China: a model simulation

Lan Yang, Jing Wang, Juan Cheng, Yuan Wang, Wenli Lu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Burden of early, advanced and metastatic breast cancer in The Netherlands

G. T. Vondeling, G. L. Menezes, E. P. Dvortsin, F. G. A. Jansman, I. R. Konings, M. J. Postma, M. H. Rozenbaum

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

GABAB receptor regulates proliferation in the high-grade chondrosarcoma cell line OUMS-27 via apoptotic pathways

Kiyoto Kanbara, Yoshinori Otsuki, Masahito Watanabe, Syunichi Yokoe, Yoshiaki Mori, Michio Asahi, Masashi Neo

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Exploration for novel inhibitors showing back-to-front approach against VEGFR-2 kinase domain (4AG8) employing molecular docking mechanism and molecular dynamics simulations

Shailima Rampogu, Ayoung Baek, Amir Zeb, Keun Woo Lee

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prevalence of pathogenic BRCA1/2 germline mutations among 802 women with unilateral triple-negative breast cancer without family cancer history

Christoph Engel, Kerstin Rhiem, Eric Hahnen, Sibylle Loibl, Karsten E. Weber, Sabine Seiler, Silke Zachariae, Jan Hauke, Barbara Wappenschmidt, Anke Waha, Britta Blümcke, Marion Kiechle, Alfons Meindl, Dieter Niederacher, Claus R. Bartram, Dorothee Speiser, Brigitte Schlegelberger, Norbert Arnold, Peter Wieacker, Elena Leinert, Andrea Gehrig, Susanne Briest, Karin Kast, Olaf Riess, Günter Emons, Bernhard H. F. Weber, Jutta Engel, Rita K. Schmutzler, on behalf of the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC)

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Scar site metastasis of renal cell carcinoma diagnosed on-site cytology: a case report

Santosh Tummidi, Pragati Sathe, Prachi Gholap, Manoj Patil, Kanchan Kothari

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comprehensive evaluation of NT5E/CD73 expression and its prognostic significance in distinct types of cancers

Tao Jiang, Xiaofeng Xu, Meng Qiao, Xuefei Li, Chao Zhao, Fei Zhou, Guanghui Gao, Fengying Wu, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Changyun Zhai, Caicun Zhou

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM

Lina Mörén, Richard Perryman, Tim Crook, Julia K. Langer, Kevin Oneill, Nelofer Syed, Henrik Antti

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

NSCLC molecular testing in Central and Eastern European countries

Ales Ryska, Peter Berzinec, Luka Brcic, Tanja Cufer, Rafal Dziadziuszko, Maya Gottfried, Ilona Kovalszky, Włodzimierz Olszewski, Buge Oz, Lukas Plank, Jozsef Timar

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Co-expression of TIMP-1 and its cell surface binding partner CD63 in glioblastomas

Charlotte Aaberg-Jessen, Mia D. Sørensen, Ana L. S. A. Matos, José M. Moreira, Nils Brünner, Arnon Knudsen, Bjarne W. Kristensen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Androgen deprivation therapy during and after post-prostatectomy radiotherapy in patients with prostate cancer: a case control study

Myong Kim, Cheryn Song, In Gab Jeong, Seung-Kwon Choi, Myungchan Park, Myungsun Shim, Young Seok Kim, Dalsan You, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

CD31 and VEGF are prognostic biomarkers in early-stage, but not in late-stage, laryngeal squamous cell carcinoma

Anke Schlüter, Patrick Weller, Oliver Kanaan, Ivonne Nel, Lukas Heusgen, Benedikt Höing, Pia Haßkamp, Sebastian Zander, Magis Mandapathil, Nina Dominas, Judith Arnolds, Boris A. Stuck, Stephan Lang, Agnes Bankfalvi, Sven Brandau

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Preventing cervical cancer using HPV self-sampling: direct mailing of test-kits increases screening participation more than timely opt-in procedures - a randomized controlled trial

Mette Tranberg, Bodil Hammer Bech, Jan Blaakær, Jørgen Skov Jensen, Hans Svanholm, Berit Andersen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

MYC amplification in subtypes of breast cancers in African American women

Tammey J. Naab, Anita Gautam, Luisel Ricks-Santi, Ashwini K. Esnakula, Yasmine M. Kanaan, Robert L. DeWitty, Girmay Asgedom, Khepher H. Makambi, Massih Abawi, Jan K. Blancato

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Diagnostic and prognostic implications of ribosomal protein transcript expression patterns in human cancers

James M. Dolezal, Arie P. Dash, Edward V. Prochownik

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Time to diagnosis and associated costs of an outpatient vs inpatient setting in the diagnosis of lymphoma: a retrospective study of a large cohort of major lymphoma subtypes in Spain

Xavier Bosch, Carmen Sanclemente-Ansó, Ona Escoda, Esther Monclús, Jonathan Franco-Vanegas, Pedro Moreno, Mar Guerra-García, Neus Guasch, Alfons López-Soto

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Sepsis increases perioperative metastases in a murine model

Lee-Hwa Tai, Abhirami A. Ananth, Rashmi Seth, Almohanad Alkayyal, Jiqing Zhang, Christiano Tanese de Souza, Phillip Staibano, Michael A. Kennedy, Rebecca C. Auer

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The prognostic value of microvascular invasion in early-intermediate stage hepatocelluar carcinoma: a propensity score matching analysis

Junyi Shen, Jun Wen, Chuan Li, Tianfu Wen, Lvnan Yan, Bo Li, Jiayin Yang, Changli Lu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Possible association between androgenic alopecia and risk of prostate cancer and testicular germ cell tumor: a systematic review and meta-analysis

Weijun Liang, Liuying Song, Zheng Peng, Yan Zou, Shengming Dai

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

Trinidad Dierssen-Sotos, Camilo Palazuelos-Calderón, José-Juan Jiménez-Moleón, Nuria Aragonés, Jone M. Altzibar, Gemma Castaño-Vinyals, Vicente Martín-Sanchez, Inés Gómez-Acebo, Marcela Guevara, Adonina Tardón, Beatriz Pérez-Gómez, Pilar Amiano, Victor Moreno, Antonio J. Molina, Jéssica Alonso-Molero, Conchi Moreno-Iribas, Manolis Kogevinas, Marina Pollán, Javier Llorca

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Clinical and misdiagnosed analysis of primary pulmonary lymphoma: a retrospective study

D. Yao, L. Zhang, P. L. Wu, X. L. Gu, Y. F. Chen, L. X. Wang, X. Y. Huang

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options

Peter F. McAnena, Andrew McGuire, A. Ramli, C. Curran, C. Malone, R. McLaughlin, K. Barry, James A. L. Brown, M. J. Kerin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The SBRT database initiative of the German Society for Radiation Oncology (DEGRO): patterns of care and outcome analysis of stereotactic body radiotherapy (SBRT) for liver oligometastases in 474 patients with 623 metastases

N. Andratschke, H. Alheid, M. Allgäuer, G. Becker, O. Blanck, J. Boda-Heggemann, T. Brunner, M. Duma, S. Gerum, M. Guckenberger, G. Hildebrandt, R. J. Klement, V. Lewitzki, C. Ostheimer, A. Papachristofilou, C. Petersen, T. Schneider, R. Semrau, S. Wachter, D. Habermehl

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression

Diana David, Arun Surendran, Jissa V. Thulaseedharan, Asha S. Nair

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prognostic nutritional index as a predictor of survival in resectable gastric cancer patients with normal preoperative serum carcinoembryonic antigen levels: a propensity score matching analysis

Noriyuki Hirahara, Yoshitsugu Tajima, Yusuke Fujii, Shunsuke Kaji, Tetsu Yamamoto, Ryoji Hyakudomi, Takahito Taniura, Yasunari Kawabata

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

A novel splicing site IRP1 somatic mutation in a patient with pheochromocytoma and JAK2V617F positive polycythemia vera: a case report

Ying Pang, Garima Gupta, Chunzhang Yang, Herui Wang, Thanh-Truc Huynh, Ziedulla Abdullaev, Svetlana D. Pack, Melanie J. Percy, Terence R. J. Lappin, Zhengping Zhuang, Karel Pacak

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Integrated genomic analysis identifies clinically relevant subtypes of renal clear cell carcinoma

Peng Wu, Jia-Li Liu, Shi-Mei Pei, Chang-Peng Wu, Kai Yang, Shu-Peng Wang, Song Wu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

Yan Qiao, Tingting Yang, Yong Gan, Wenzhen Li, Chao Wang, Yanhong Gong, Zuxun Lu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Using nomogram of the Barcelona Clinic Liver Cancer system for treatment selection in patients with stage C hepatocellular carcinoma

Chia-Yang Hsu, Po-Hong Liu, Shu-Yein Ho, Cheng-Yuan Hsia, Praneeth Kudaravalli, Yun-Hsuan Lee, Yi-You Chiou, Ya-Ju Tsai, Yi-Hsiang Huang, Teh-Ia Huo

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A comparison of nephrotoxicity between patients with a solitary-functioning kidney and those with bilateral-functioning kidneys in cisplatin-based chemotherapy for advanced urothelial carcinoma: a Japanese retrospective multi-institutional study

Takamitsu Inoue, Jun Miyazaki, Daishi Ichioka, Shintaro Narita, Susumu Kageyama, Mikio Sugimoto, Koji Mitsuzuka, Yusuke Shiraishi, Hidefumi Kinoshita, Hironobu Wakeda, Takeshi Nomoto, Eiji Kikuchi, Yoshiyuki Matsui, Keiko Fujie, Tomonori Habuchi, Hiroyuki Nishiyama

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Thyroid cancer: trends in incidence, mortality and clinical-pathological patterns in Zhejiang Province, Southeast China

Lingbin Du, Youqing Wang, Xiaohui Sun, Huizhang Li, Xinwei Geng, Minghua Ge, Yimin Zhu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study

Hanaa Hardi, Rahma Melki, Zouhour Boughaleb, Tijani El Harroudi, Souria Aissaoui, Noureddine Boukhatem

01.12.2018 | Debate | Ausgabe 1/2018 Open Access

The curious case of Gαs gain-of-function in neoplasia

Giulio Innamorati, Thomas M. Wilkie, Havish S. Kantheti, Maria Teresa Valenti, Luca Dalle Carbonare, Luca Giacomello, Marco Parenti, Davide Melisi, Claudio Bassi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Knowledge, attitudes, and practices toward cervical cancer prevention among women in Kampong Speu Province, Cambodia

Sothy Touch, Jin-Kyoung Oh

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Long-term trastuzumab (Herceptin®) treatment in a continuation study of patients with HER2-positive breast cancer or HER2-positive gastric cancer

Volkmar Müller, Michael Clemens, Jacek Jassem, Nedal Al-Sakaff, Petra Auclair, Eveline Nüesch, Debbie Holloway, Mona Shing, Yung-Jue Bang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Dose escalation can maximize therapeutic potential of sunitinib in patients with metastatic renal cell carcinoma

Anikó Maráz, Adrienn Cserháti, Gabriella Uhercsák, Éva Szilágyi, Zoltán Varga, János Révész, Renáta Kószó, Linda Varga, Zsuzsanna Kahán

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Phase II trial to investigate the safety and efficacy of orally applied niclosamide in patients with metachronous or sychronous metastases of a colorectal cancer progressing after therapy: the NIKOLO trial

Susen Burock, Severin Daum, Ulrich Keilholz, Konrad Neumann, Wolfgang Walther, Ulrike Stein

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Health seeking behavior and its determinants for cervical cancer among women of childbearing age in Hossana Town, Hadiya zone, Southern Ethiopia: community based cross sectional study

Yitagesu Habtu, Samuel Yohannes, Tariku Laelago

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cancer awareness among community pharmacist: a systematic review

Kofi Boamah Mensah, Frasia Oosthuizen, Adwoa Bemah Bonsu

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Acantholytic squamous cell carcinoma of the lung with marked lymphogenous metastases and high titers of myeloperoxidase-antineutrophil cytoplasmic antibodies: a case report

Kenji Yorita, Kazuya Tsuji, Yoko Takano, Naoto Kuroda, Kei Sakamoto, Kaoru Arii, Yukio Yoshimoto, Kimiko Nakatani, Satoshi Ito

01.12.2018 | Gastrointestinale Tumoren | Case report | Ausgabe 1/2018 Open Access

Unusual bilateral ovarian metastases from ileal gastrointestinal stromal tumor (GIST): a case report

Antonio De Leo, Margherita Nannini, Giulia Dondi, Donatella Santini, Milena Urbini, Elisa Gruppioni, Pierandrea De Iaco, Anna Myriam Perrone, Maria Abbondanza Pantaleo

01.12.2018 | NSCLC | Case report | Ausgabe 1/2018 Open Access

Re-challenging immune checkpoint inhibitor in a patient with advanced non-small cell lung cancer: a case report

Taiki Hakozaki, Yusuke Okuma, Jumpei Kashima

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

CircRNAs as biomarkers of cancer: a meta-analysis

Miao Wang, Yuxi Yang, Jian Xu, Wen Bai, Xueli Ren, Huijian Wu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Myxoid liposarcoma: local relapse and metastatic pattern in 43 patients

Hans Roland Dürr, Jessica Rauh, Andrea Baur-Melnyk, Thomas Knösel, Lars Lindner, Falk Roeder, Volkmar Jansson, Alexander Klein

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Relationship between time elapsed since completion of radiotherapy and quality of life of patients with breast cancer

Jing-Jie Zhang, Hang Shu, Shuai-Shuai Hu, Yang Yu, Yi Sun, Yin Lv

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Underutilization and disparities in access to EGFR testing among Medicare patients with lung cancer from 2010 – 2013

Julie A. Lynch, Brygida Berse, Merry Rabb, Paul Mosquin, Rob Chew, Suzanne L. West, Nicole Coomer, Daniel Becker, John Kautter

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Novel biomarker-based model for the prediction of sorafenib response and overall survival in advanced hepatocellular carcinoma: a prospective cohort study

Hwi Young Kim, Dong Hyeon Lee, Jeong-Hoon Lee, Young Youn Cho, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The effect of surgery on the survival status of patients with locally advanced cervical cancer after radiotherapy/chemoradiotherapy: a meta-analysis

Dan Shi, Zhenzhen Liang, Cheng Zhang, Huaiyu Zhang, Xiaodong Liu

01.12.2018 | Review article | Ausgabe 1/2018 Open Access

Impact of RUNX2 on drug-resistant human pancreatic cancer cells with p53 mutations

Toshinori Ozaki, Meng Yu, Danjing Yin, Dan Sun, Yuyan Zhu, Youquan Bu, Meixiang Sang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The serum-based VeriStrat® test is associated with proinflammatory reactants and clinical outcome in non-small cell lung cancer patients

Mary Jo Fidler, Cristina L. Fhied, Joanna Roder, Sanjib Basu, Selina Sayidine, Ibtihaj Fughhi, Mark Pool, Marta Batus, Philip Bonomi, Jeffrey A. Borgia

01.12.2018 | Bronchialkarzinome | Case report | Ausgabe 1/2018 Open Access

Efficacy and safety of everolimus treatment in a hemodialysis patient with metastatic atypical bronchial carcinoid: case report and literature review

M. P. Brizzi, A. La Salvia, M. Tampellini, C. Sonetto, M. Volante, G. V. Scagliotti

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

From symptom discovery to treatment - women's pathways to breast cancer care: a cross-sectional study

Jennifer Moodley, Lydia Cairncross, Thurandrie Naiker, Deborah Constant

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Tumor-infiltrating mast cells predict prognosis and gemcitabine-based adjuvant chemotherapeutic benefit in biliary tract cancer patients

Xiaobo Bo, Jie Wang, Tao Suo, Xiaoling Ni, Han Liu, Sheng Shen, Min Li, Yueqi Wang, Houbao Liu, Jiejie Xu

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Effective osimertinib treatment in a patient with discordant T790 M mutation detection between liquid biopsy and tissue biopsy

Isa Mambetsariev, Lalit Vora, Kim Wai Yu, Ravi Salgia

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Germline breast cancer susceptibility gene mutations and breast cancer outcomes

Yong Alison Wang, Jhih-Wei Jian, Chen-Fang Hung, Hung-Pin Peng, Chi-Fan Yang, Hung-Chun Skye Cheng, An-Suei Yang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Age greater than 60 years portends a worse prognosis in patients with papillary thyroid cancer: should there be three age categories for staging?

Rondi M. Kauffmann, J. Blair Hamner, Philip H. G. Ituarte, John H. Yim

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

Junya Matsushita, Kazuyuki Okamura, Kazuhiko Nakabayashi, Takehiro Suzuki, Yu Horibe, Tomoko Kawai, Toshihiro Sakurai, Satoshi Yamashita, Yoshikazu Higami, Gaku Ichihara, Kenichiro Hata, Keiko Nohara

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Punch biopsies shorten time to clearance of high-risk human papillomavirus infections of the uterine cervix

K. U. Petry, J. Horn, A. Luyten, R. T. Mikolajczyk

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The characteristics of ctDNA reveal the high complexity in matching the corresponding tumor tissues

Nong Yang, Yi Li, Zhidong Liu, Hao Qin, Duanming Du, Xinkai Cao, Xiaoqing Cao, Jun Li, Dongge Li, Bo Jiang, Lincan Duan, Haiyan Yang, Zhenghua Zhang, Hao Lin, Jianying Li, Zhenhua Yang, Lei Xiong, Hua Shen, Lizhu Lin, Fugen Li

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comparisons of tumor-infiltrating lymphocyte levels and the 21-gene recurrence score in ER-positive/HER2-negative breast cancer

Sung Gwe Ahn, Yoon Jin Cha, Soon June Bae, Chanik Yoon, Hak Woo Lee, Joon Jeong

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Carcinoembryonic antigen as a marker of radioresistance in colorectal cancer: a potential role of macrophages

Eng-Yen Huang, Jen-Chieh Chang, Hong-Hwa Chen, Chieh-Ying Hsu, Hsuan-Chih Hsu, Keng-Liang Wu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Mental disorders around cancer diagnosis and increased hospital admission rate - a nationwide cohort study of Swedish cancer patients

Jianwei Zhu, Arvid Sjölander, Katja Fall, Unnur Valdimarsdottir, Fang Fang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Anti-EGFR targeted therapy delivered before versus during radiotherapy in locoregionally advanced nasopharyngeal carcinoma: a big-data, intelligence platform-based analysis

Hao Peng, Ling-Long Tang, Xu Liu, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Yuan Zhang, Li-Zhi Liu, Li Tian, Ying Guo, Ying Sun, Jun Ma

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Frequency of HPV in oral cavity squamous cell carcinoma

Priscila Marinho de Abreu, Anna Clara Gregório Có, Pedro Leite Azevedo, Isabella Bittencourt do Valle, Karine Gadioli de Oliveira, Sônia Alves Gouvea, Melissa Freitas Cordeiro-Silva, Iúri Drummond Louro, José Roberto Vasconcelos de Podestá, Jeferson Lenzi, Agenor Sena, Elismauro Francisco Mendonça, Sandra Lúcia Ventorin von Zeidler

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cells

Elisa M. Vuorinen, Nina K. Rajala, Teemu O. Ihalainen, Anne Kallioniemi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Outcomes of Pemetrexed-based chemotherapies in HER2-mutant lung cancers

Yan Wang, Shijia Zhang, Fengying Wu, Jing Zhao, Xuefei Li, Chao Zhao, Shengxiang Ren, Caicun Zhou

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Nomograms predict long-term survival for patients with periampullary adenocarcinoma after pancreatoduodenectomy

Chaobin He, Yize Mao, Jun Wang, Fangting Duan, Xiaojun Lin, Shengping Li

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

GDF15 predict platinum response during first-line chemotherapy and can act as a complementary diagnostic serum biomarker with CA125 in epithelial ovarian cancer

Dan Zhao, Xiaobing Wang, Wei Zhang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in locally advanced nasopharyngeal carcinoma

Jiraporn Setakornnukul, Kullathorn Thephamongkhol

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-γ-linolenic acid peroxidation dependent mechanism

Yi Xu, Xiaoyu Yang, Tao Wang, Liu Yang, Yu-Ying He, Keith Miskimins, Steven Y. Qian

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The prognostic significance of topoisomerase II alpha protein in early stage luminal breast cancer

Xin An, Fei Xu, Rongzhen Luo, Qiufan Zheng, Jiabin Lu, Yanhua Yang, Tao Qin, Zhongyu Yuan, Yanxia Shi, Wenqi Jiang, Shusen Wang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A phase I/Ib study of OTSGC-A24 combined peptide vaccine in advanced gastric cancer

Raghav Sundar, Sun Young Rha, Hiroki Yamaue, Masahiro Katsuda, Koji Kono, Hyo Song Kim, Chan Kim, Kousaku Mimura, Ley-Fang Kua, Wei Peng Yong

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Erlotinib treatment after platinum-based therapy in elderly patients with non-small-cell lung cancer in routine clinical practice – results from the ElderTac study

Wolfgang M. Brueckl, H. Jost Achenbach, Joachim H. Ficker, Wolfgang Schuette

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Shorter survival in adolescent and young adult patients, compared to adult patients, with stage IV colorectal cancer in Japan

Dai Shida, Yuka Ahiko, Taro Tanabe, Takefumi Yoshida, Shunsuke Tsukamoto, Hiroki Ochiai, Atsuo Takashima, Narikazu Boku, Yukihide Kanemitsu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models

Susan Tsai, Laura McOlash, Katie Palen, Bryon Johnson, Christine Duris, Qiuhui Yang, Michael B. Dwinell, Bryan Hunt, Douglas B. Evans, Jill Gershan, Michael A. James

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Detection of circulating tumor cells in patients with pituitary tumors

Gao Hua, He Yanjiao, Liu Qian, Wang Jichao, Zhang Yazhuo

01.12.2018 | Debate | Ausgabe 1/2018 Open Access

To fast, or not to fast before chemotherapy, that is the question

Riccardo Caccialanza, Emanuele Cereda, Francesco De Lorenzo, Gabriella Farina, Paolo Pedrazzoli, on behalf of the AIOM-SINPE-FAVO Working Group

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Effective treatment of apatinib in desmoplastic small round cell tumor: a case report and literature review

Chunyu Shi, Ye Feng, Lei Chao Zhang, Da Yong Ding, Ming Yu Yan, Lu Pan

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Patterns of follow up and survivorship care for people with colorectal cancer in new South Wales, Australia: a population-based survey

Jane M. Young, Ivana Durcinoska, Katie DeLoyde, Michael J. Solomon

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Randomized clinical trial testing the efficacy and safety of 0.5% colchicine cream versus photodynamic therapy with methyl aminolevulinate in the treatment of skin field cancerization: study protocol

Anna Carolina Miola, Eliane Roio Ferreira, Luciana Patricia Fernandes Abbade, Juliano Vilaverde Schmitt, Helio Amante Miot

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Activated innate lymphoid cell populations accumulate in human tumour tissues

Maryam Salimi, Ruozheng Wang, Xuan Yao, Xi Li, Xiyan Wang, Yuhui Hu, Xumei Chang, Peiwen Fan, Tao Dong, Graham Ogg

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Delphinidin induced protective autophagy via mTOR pathway suppression and AMPK pathway activation in HER-2 positive breast cancer cells

Jingyao Chen, Yanfeng Zhu, Weiwei Zhang, Xiaoli Peng, Jie Zhou, Fei Li, Bin Han, Xin Liu, Yu Ou, Xiaoping Yu

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Coexisting of bone marrow fibrosis, dysplasia and an X chromosomal abnormality in chronic neutrophilic leukemia with CSF3R mutation: a case report and literature review

Xue Bin Wu, Wei Wei Wu, Yue Zhou, Xuan Wang, Jia Li, Yang Yu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Expression of Reg IV and SOX9 and their correlation in human gastric cancer

Na Zhang, Dandan Chai, Huifen Du, Kesheng Li, Wenguang Xie, Xingwen Li, Rong Yang, Xiaowen Lian, Yang Xu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Association between age factors and strategies for promoting participation in gastric and colorectal cancer screenings

Chisato Hamashima, Hiroshi Sano

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A national cross-sectional study of adherence to timely mammography use in Malta

Danika Marmarà, Vincent Marmarà, Gill Hubbard

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers

Cécile Le Page, Kurosh Rahimi, Martin Köbel, Patricia N. Tonin, Liliane Meunier, Lise Portelance, Monique Bernard, Brad H. Nelson, Marcus Q. Bernardini, John M. S. Bartlett, Dimcho Bachvarov, Walter H. Gotlieb, Blake Gilks, Jessica N. McAlpine, Mark W. Nachtigal, Alain Piché, Peter H. Watson, Barbara Vanderhyden, David G. Huntsman, Diane M. Provencher, Anne-Marie Mes-Masson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Androgen receptor in advanced breast cancer: is it useful to predict the efficacy of anti-estrogen therapy?

Giuseppe Bronte, Andrea Rocca, Sara Ravaioli, Maurizio Puccetti, Maria Maddalena Tumedei, Emanuela Scarpi, Daniele Andreis, Roberta Maltoni, Samanta Sarti, Lorenzo Cecconetto, Anna Fedeli, Elisabetta Pietri, Valeria De Simone, Silvia Asioli, Dino Amadori, Sara Bravaccini

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Ezrin and E-cadherin expression profile in cervical cytology: a prognostic marker for tumor progression in cervical cancer

Ana E. Zacapala-Gómez, Napoleón Navarro-Tito, Luz del C. Alarcón-Romero, Carlos Ortuño-Pineda, Berenice Illades-Aguiar, Eduardo Castañeda-Saucedo, Julio Ortiz-Ortiz, Olga L. Garibay-Cerdenares, Marco A. Jiménez-López, Miguel A. Mendoza-Catalán

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Quality of life of survivors of malignant pleural mesothelioma in Japan: a cross sectional study

Yasuko Nagamatsu, Isao Oze, Keisuke Aoe, Katsuyuki Hotta, Katsuya Kato, Junko Nakagawa, Keiko Hara, Takumi Kishimoto, Nobukazu Fujimoto

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Impact of a behaviorally-based weight loss intervention on parameters of insulin resistance in breast cancer survivors

Kim L. Dittus, Jean R. Harvey, Janice Y. Bunn, Nathan D. Kokinda, Karen M. Wilson, Jeff Priest, Richard E. Pratley

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cost effectiveness analysis of afatinib versus pemetrexed-cisplatin for first-line treatment of locally advanced or metastatic EGFR mutation positive non-small-cell lung cancer from the Singapore healthcare payer’s perspective

Ping-Tee Tan, Mohamed Ismail Abdul Aziz, Fiona Pearce, Wan-Teck Lim, David Bin-Chia Wu, Kwong Ng

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Validation of the Taiwan Chinese version of the EORTC QLQ-CR29 to assess quality of life in colorectal cancer patients

Ming-Hung Shen, Ling-Ping Chen, Thien-Fiew Ho, Ying-Yih Shih, Ching-Shui Huang, Wei-Chu Chie, Chi-Cheng Huang

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Neoadjuvant degarelix with or without apalutamide followed by radical prostatectomy for intermediate and high-risk prostate cancer: ARNEO, a randomized, double blind, placebo-controlled trial

Lorenzo Tosco, Annouschka Laenen, Thomas Gevaert, Isabelle Salmon, Christine Decaestecker, Elai Davicioni, Christine Buerki, Frank Claessens, Johan Swinnen, Karolien Goffin, Raymond Oyen, Wouter Everaerts, Lisa Moris, Gert De Meerleer, Karin Haustermans, Steven Joniau, P.E.A.R.L. (ProstatE cAncer Research Leuven)

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

Elizabeth Bowler, Sean Porazinski, Simon Uzor, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Kasper M. A. Rouschop, John Hancock, Ian Wilson, Michael Ladomery

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The alterations of cytokeratin and vimentin protein expressions in primary esophageal spindle cell carcinoma

Xin Min Li, Xin Song, Xue Ke Zhao, Shou Jia Hu, Rang Cheng, Shuang Lv, Dan Feng Du, Xiang Yang Zhang, Jian Liang Lu, Jian Wei Ku, Dong Yun Zhang, Yao Zhang, Zong Min Fan, Li Dong Wang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Significance of CD133 positive cells in four novel HPV-16 positive cervical cancer-derived cell lines and biopsies of invasive cervical cancer

Shifa Javed, Bal Krishan Sharma, Swati Sood, Sanjeev Sharma, Rashmi Bagga, Shalmoli Bhattacharyya, Charan Singh Rayat, Lakhbir Dhaliwal, Radhika Srinivasan

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The identification of H3F3A mutation in giant cell tumour of the clivus and the histological diagnostic algorithm of other clival lesions permit the differential diagnosis in this location

Federica Scotto di Carlo, Giuseppina Divisato, Maurizio Iacoangeli, Teresa Esposito, Fernando Gianfrancesco

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Design and rationale for the life after stopping tyrosine kinase inhibitors (LAST) study, a prospective, single-group longitudinal study in patients with chronic myeloid leukemia

Ehab Atallah, Charles A. Schiffer, Kevin P. Weinfurt, Mei-Jie Zhang, Jerald P. Radich, Vivian G. Oehler, Javier Pinilla-Ibarz, Michael W. N. Deininger, Li Lin, Richard A. Larson, Michael J. Mauro, Joseph O. Moore, Ellen K. Ritchie, Neil P. Shah, Richard T. Silver, Martha Wadleigh, Jorge Cortes, James Thompson, Jessica Guhl, Mary M. Horowitz, Kathryn E. Flynn

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The Warburg effect in human pancreatic cancer cells triggers cachexia in athymic mice carrying the cancer cells

Feng Wang, Hongyi Liu, Lijuan Hu, Yunfei Liu, Yijie Duan, Rui Cui, Wencong Tian

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma

Chengsheng Wu, Nidhi Gupta, Yung-Hsing Huang, Hai-Feng Zhang, Abdulraheem Alshareef, Alexandra Chow, Raymond Lai

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A study on volatile organic compounds emitted by in-vitro lung cancer cultured cells using gas sensor array and SPME-GCMS

Reena Thriumani, Ammar Zakaria, Yumi Zuhanis Has-Yun Hashim, Amanina Iymia Jeffree, Khaled Mohamed Helmy, Latifah Munirah Kamarudin, Mohammad Iqbal Omar, Ali Yeon Md Shakaff, Abdul Hamid Adom, Krishna C. Persaud

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Negative cancer beliefs, recognition of cancer symptoms and anticipated time to help-seeking: an international cancer benchmarking partnership (ICBP) study

Anette Fischer Pedersen, Lindsay Forbes, Kate Brain, Line Hvidberg, Christian Nielsen Wulff, Magdalena Lagerlund, Senada Hajdarevic, Samantha L. Quaife, Peter Vedsted

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Internet-based self-help smoking cessation and alcohol moderation interventions for cancer survivors: a study protocol of two RCTs

Ajla Mujcic, Matthijs Blankers, Brigitte Boon, Rutger Engels, Margriet van Laar

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Higher satisfaction with an alternative collection device for stool sampling in colorectal cancer screening with fecal immunochemical test: a cross-sectional study

Hye Young Shin, Mina Suh, Kui Son Choi, Sang-Hyun Hwang, Jae Kwan Jun, Dong Soo Han, You Kyoung Lee, Jae Hwan Oh, Chan Wha Lee, Do-Hoon Lee

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Altered monocyte differentiation and macrophage polarization patterns in patients with breast cancer

Chih-Hsing Hung, Fang-Ming Chen, Yi-Ching Lin, Mei-Lan Tsai, Shih-Ling Wang, Yen-Chun Chen, Yi-Ting Chen, Ming-Feng Hou

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Up-regulation of ceRNA TINCR by SP1 contributes to tumorigenesis in breast cancer

Yun Liu, Yaying Du, Xiaopeng Hu, Lu Zhao, Wenfei Xia

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Impact of resistance training on body composition and metabolic syndrome variables during androgen deprivation therapy for prostate cancer: a pilot randomized controlled trial

Jacqueline K. Dawson, Tanya B. Dorff, E. Todd Schroeder, Christianne J. Lane, Mitchell E. Gross, Christina M. Dieli-Conwright

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Influence of complete administration of adjuvant chemotherapy cycles on overall and disease-free survival in locally advanced rectal cancer: post hoc analysis of a randomized, multicenter, non-inferiority, phase 3 trial

Flavius Sandra-Petrescu, Florian Herrle, Iris Burkholder, Peter Kienle, Ralf-Dieter Hofheinz

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Laparoscopy-assisted colectomy as an Oncologically safe alternative for patients with stage T4 Colon Cancer: a propensity-matched cohort study

Hao Wang, Xiaoyu Chen, Hao Liu, Tingyu Mou, Haijun Deng, Liying Zhao, Guoxin Li

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A comparison of the local immune status between the primary and metastatic tumor in colorectal cancer: a retrospective study

Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Shinichiro Kashiwagi, Hiroaki Tanaka, Kosei Hirakawa, Masaichi Ohira

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Compared characteristics of current vs. past smokers at the time of diagnosis of a first-time lung or head and neck cancer: a cross-sectional study

Corinne Vannimenus, Hélène Bricout, Olivier Le Rouzic, François Mouawad, Dominique Chevalier, Eric Dansin, Laurence Rotsaert, Gautier Lefebvre, Olivier Cottencin, Henri Porte, Arnaud Scherpereel, Asmaa El Fahsi, Florence Richard, Benjamin Rolland, The ALTAK Study Group

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Epstein-Barr virus positive peripheral T cell lymphoma with novel variants in STAT5B of a pediatric patient: a case report

Zihang Chen, Limin Gao, Mi Wang, Yuan Tang, Sha Zhao, Weiping Liu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Role of cytarabine in paediatric acute promyelocytic leukemia treated with the combination of all-trans retinoic acid and arsenic trioxide: a randomized controlled trial

Li Zhang, Yao Zou, Yumei Chen, Ye Guo, Wenyu Yang, Xiaojuan Chen, Shuchun Wang, Xiaoming Liu, Min Ruan, Jiayuan Zhang, Tianfeng Liu, Fang Liu, Benquan Qi, Wenbin An, Yuanyuan Ren, Lixian Chang, Xiaofan Zhu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Gynecologic cancer survivor preferences for long-term surveillance

Matthew Schlumbrecht, Charlotte Sun, Marilyn Huang, Andrea Milbourne, Diane Bodurka

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Modeling treatment-dependent glioma growth including a dormant tumor cell subpopulation

Marvin A. Böttcher, Janka Held-Feindt, Michael Synowitz, Ralph Lucius, Arne Traulsen, Kirsten Hattermann

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer

Azeez A. Fatai, Junaid Gamieldien

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Chemoradiotherapy versus chemotherapy as adjuvant treatment for localized gastric cancer: a propensity score-matched analysis

Daniel M. Girardi, Mariana A. de Lima, Gabriel C. B. Pereira, Marcelo V. Negrão, Rossana V. M. López, Fernanda C. Capareli, Jorge Sabbaga, Paulo Marcelo G. Hoff

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells

Chung-Ching Chio, Kung-Yen Chen, Cheng-Kuei Chang, Jian-Ying Chuang, Chih-Chung Liu, Shing-Hwa Liu, Ruei-Ming Chen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts – a systematic review and meta-analysis

Xuan-Anh Phi, Alberto Tagliafico, Nehmat Houssami, Marcel J. W. Greuter, Geertruida H. de Bock

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cancer patients’ knowledge about their disease and treatment before, during and after treatment: a prospective, longitudinal study

Ola Berger, Bjørn Henning Grønberg, Jon Håvard Loge, Stein Kaasa, Kari Sand

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model

Patricia Luiza Nunes da Costa, David Wynne, Theodora Fifis, Linh Nguyen, Marcos Perini, Christopher Christophi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Pretreatment neutrophil to lymphocyte ratio in determining the prognosis of head and neck cancer: a meta-analysis

Yalian Yu, Hongbo Wang, Aihui Yan, Hailong Wang, Xinyao Li, Jiangtao Liu, Wei Li

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Sequential tests for monitoring methods to detect elevated incidence – a simulation study

Tammo Konstantin Reinders, Joachim Kieschke, Antje Timmer, Verena Jürgens

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma

Frank K. Leusink, Eleftherios Koudounarakis, Michael H. Frank, Ronald Koole, Paul J. van Diest, Stefan M. Willems

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Breast density and breast cancer-specific survival by detection mode

Daniëlle van der Waal, André L. M. Verbeek, Mireille J. M. Broeders

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Histo-epidemiological profile of breast cancers among women in the Central African Republic: about 174 cases

Augustin Balekouzou, Ping Yin, Cavin Epi Bekolo, Christian Maucler Pamatika, Marceline Djeintote, Sylvain Wilfrid Nambei, Bertrand Ba-Mpoutou, Dieubeni Rawago Mandjiza, Chang Shu, Minghui Yin, Tingting Qing, Boniface Koffi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study

Christine Barul, Matthieu Carton, Loredana Radoï, Gwenn Menvielle, Corinne Pilorget, Simona Bara, Isabelle Stücker, Danièle Luce, ICARE study group

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

The PiGeOn project: protocol for a longitudinal study examining psychosocial, behavioural and ethical issues and outcomes in cancer tumour genomic profiling

Megan Best, Ainsley J. Newson, Bettina Meiser, Ilona Juraskova, David Goldstein, Kathy Tucker, Mandy L. Ballinger, Dominique Hess, Timothy E. Schlub, Barbara Biesecker, Richard Vines, Kate Vines, David Thomas, Mary-Anne Young, Jacqueline Savard, Chris Jacobs, Phyllis Butow

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Using a nomogram based on preoperative serum fibrinogen levels to predict recurrence of papillary thyroid carcinoma

Lei Jianyong, Li Zhihui, Gong Rixiang, Zhu Jingqiang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Adjuvant trastuzumab duration trials in HER2 positive breast cancer – what results would be practice-changing? Persephone investigator questionnaire prior to primary endpoint results

Louise Hiller, Janet A. Dunn, Shrushma Loi, Anne-Laure Vallier, Donna L. Howe, David A. Cameron, David Miles, Andrew M. Wardley, Helena M. Earl

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Sorafenib versus Transarterial chemoembolization for advanced-stage hepatocellular carcinoma: a cost-effectiveness analysis

Shuling Chen, Zhenwei Peng, Mengchao Wei, Weifeng Liu, Zihao Dai, Haibo Wang, Jie Mei, Mingfong Cheong, Hanmei Zhang, Ming Kuang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Aggressive primary treatments with favourable 5-year survival for screen-interval breast cancers

Gautier Defossez, Alexandre Quillet, Pierre Ingrand

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

What is the impact of rerouting a cancer diagnosis from emergency presentation to GP referral on resource use and survival? Evidence from a population-based study

Mauro Laudicella, Brendan Walsh, Elaine Burns, Paolo Li Donni, Peter C. Smith

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Radiotherapy-induced anti-tumor immune response and immune-related adverse events in a case of recurrent nasopharyngeal carcinoma undergoing anti-PD-1 immunotherapy

T. Finazzi, T. Rordorf, K. Ikenberg, G. F. Huber, M. Guckenberger, H. I. Garcia Schueler

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Apatinib for advanced sarcoma: results from multiple institutions’ off-label use in China

Lu Xie, Wei Guo, Ye Wang, Taiqiang Yan, Tao Ji, Jie Xu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Dynamic imaging and pathological changes in pig liver after MR-guided microwave ablation

Jun Dong, Xiaojing Geng, Yadi Yang, Xiuyu Cai, Pili Hu, Liangping Xia, Bei Zhang, Peihong Wu

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

The first case of SMARCB1 (INI1) - deficient squamous cell carcinoma of the pleura: a case report

Kazushi Yoshida, Yutaka Fujiwara, Yasushi Goto, Takashi Kohno, Akihiko Yoshida, Koji Tsuta, Yuichiro Ohe

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comparative analysis of histologically classified oligodendrogliomas reveals characteristic molecular differences between subgroups

Chris Lauber, Barbara Klink, Michael Seifert

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

CTHRC1 induces non-small cell lung cancer (NSCLC) invasion through upregulating MMP-7/MMP-9

Weiling He, Hui Zhang, Yuefeng Wang, Yanbin Zhou, Yifeng Luo, Yongmei Cui, Neng Jiang, Wenting Jiang, Han Wang, Di Xu, Shuhua Li, Zhuo Wang, Yangshan Chen, Yu Sun, Yang Zhang, Hsian-Rong Tseng, Xuenong Zou, Liantang Wang, Zunfu Ke

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in chemoprevention of hepatocellular carcinoma: a nationwide high-risk cohort study

Cheng-Maw Ho, Chih-Hsin Lee, Ming-Chia Lee, Jun-Fu Zhang, Jann-Yuan Wang, Rey-Heng Hu, Po-Huang Lee

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Trends in the contemporary incidence of colorectal cancer and patient characteristics in the United Kingdom: a population-based cohort study using The Health Improvement Network

Lucía Cea Soriano, Montse Soriano-Gabarró, Luis A. García Rodríguez

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Survival analysis of patients with invasive extramammary Paget disease: implications of anatomic sites

Haijun Yao, Minkai Xie, Shibo Fu, Jianhua Guo, Yubing Peng, Zhikang Cai, Yueqing Jiang, Dachao Zheng, Zhong Wang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

MiR-30a-5p confers cisplatin resistance by regulating IGF1R expression in melanoma cells

Yuxia Li, Jie Zhang, Yajing Liu, Bingyue Zhang, Fubo Zhong, Shubin Wang, Zhengyu Fang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Identification of methylation sites and signature genes with prognostic value for luminal breast cancer

Bin Xiao, Lidan Chen, Yongli Ke, Jianfeng Hang, Ling Cao, Rong Zhang, Weiyun Zhang, Yang Liao, Yang Gao, Jianyun Chen, Li Li, Wenbo Hao, Zhaohui Sun, Linhai Li

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Serum leucine-rich alpha-2-glycoprotein-1 with fucosylated triantennary N-glycan: a novel colorectal cancer marker

Eiji Shinozaki, Kazuhiro Tanabe, Takashi Akiyoshi, Tomohiro Tsuchida, Yuko Miyazaki, Nozomi Kojima, Masahiro Igarashi, Masashi Ueno, Mitsukuni Suenaga, Nobuyuki Mizunuma, Kensei Yamaguchi, Konosuke Nakayama, Sadayo Iijima, Toshiharu Yamaguchi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Bexarotene inhibits the viability of non-small cell lung cancer cells via slc10a2/PPARγ/PTEN/mTOR signaling pathway

Xinghao Ai, Feng Mao, Shengping Shen, Yang Shentu, Jiejun Wang, Shun Lu

01.12.2018 | Debate | Ausgabe 1/2018 Open Access

In silico cancer research towards 3R

Claire Jean-Quartier, Fleur Jeanquartier, Igor Jurisica, Andreas Holzinger

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Bile acids at neutral and acidic pH induce apoptosis and gene cleavages in nasopharyngeal epithelial cells: implications in chromosome rearrangement

Sang-Nee Tan, Sai-Peng Sim

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The incidence of acute oxaliplatin-induced neuropathy and its impact on treatment in the first cycle: a systematic review

Endale Gebreegziabher Gebremedhn, Peter John Shortland, David Anthony Mahns

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Evaluation of efficacy and safety for Brucea javanica oil emulsion in the control of the malignant pleural effusions via thoracic perfusion

Dai Fuhong, Gao Xiang, Li Haiying, Wang Jiangye, Gao Xueming, Chai Wenxiao

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway

Melissa M. Ledet, Robyn Anderson, Rebecca Harman, Aaron Muth, Paul R. Thompson, Scott A. Coonrod, Gerlinde R. Van de Walle

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Genomics of NSCLC patients both affirm PD-L1 expression and predict their clinical responses to anti-PD-1 immunotherapy

Kim A. Brogden, Deepak Parashar, Andrea R. Hallier, Terry Braun, Fang Qian, Naiyer A. Rizvi, Aaron D. Bossler, Mohammed M. Milhem, Timothy A. Chan, Taher Abbasi, Shireen Vali

01.12.2018 | Technical advance | Ausgabe 1/2018 Open Access

Population-level distribution and putative immunogenicity of cancer neoepitopes

Mary A. Wood, Mayur Paralkar, Mihir P. Paralkar, Austin Nguyen, Adam J. Struck, Kyle Ellrott, Adam Margolin, Abhinav Nellore, Reid F. Thompson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer

Hai-Ning Liu, Hao Wu, Yu-Jen Tseng, Yan-Jie Chen, Dan-Ying Zhang, Lin Zhu, Ling Dong, Xi-Zhong Shen, Tao-Tao Liu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Stereotactic body radiation therapy using a respiratory-gated volumetric-modulated arc therapy technique for small hepatocellular carcinoma

Yuri Jeong, Jinhong Jung, Byungchul Cho, Jungwon Kwak, Chiyoung Jeong, Jong Hoon Kim, Jin-hong Park, So Yeon Kim, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Sang Min Yoon

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prognostic value of serum CYFRA 21-1 1 in patients with anal canal squamous cell carcinoma treated with radio(chemo)therapy

Mathieu Gauthé, Marion Richard-Molard, Eugénie Rigault, Bruno Buecher, Pascale Mariani, Dominique Bellet, Wulfran Cacheux, Astrid Lièvre

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Non-endometrioid and high-grade endometrioid endometrial cancers show DNA fragmentation factor 40 (DFF40) and B-cell lymphoma 2 protein (BCL2) underexpression, which predicts disease-free and overall survival, but not DNA fragmentation factor 45 (DFF45) underexpression

Tomasz Banas, Kazimierz Pitynski, Krzysztof Okon, Aleksandra Winiarska

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

ZBP-89 and Sp1 contribute to Bak expression in hepatocellular carcinoma cells

Xia Kong, Pin Xu, Wei-Jie Cai, Huai-Gao Wang, Bin-Bin Li, Guo-Liang Huang, Zhi-Wei He, George Chen, Cai-Guo Ye

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Impact of Myeloproliferative neoplasms on patients’ employment status and work productivity in the United States: results from the living with MPNs survey

Jingbo Yu, Shreekant Parasuraman, Dilan Paranagama, Andrew Bai, Ahmad Naim, David Dubinski, Ruben Mesa

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Micro-RNA-186-5p inhibition attenuates proliferation, anchorage independent growth and invasion in metastatic prostate cancer cells

Dominique Z. Jones, M. Lee Schmidt, Suman Suman, Katharine R. Hobbing, Shirish S. Barve, Leila Gobejishvili, Guy Brock, Carolyn M. Klinge, Shesh N. Rai, Jong Park, Geoffrey J. Clark, Rajesh Agarwal, LaCreis R. Kidd

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Diabetes mellitus and the risk of gastrointestinal cancer in women compared with men: a meta-analysis of cohort studies

Hong-juan FANG, Shao-bo SHAN, Yu-hao ZHOU, Li-yong ZHONG

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?

Hussein H. K. Abbas, Kheloud M. H. Alhamoudi, Mark D. Evans, George D. D. Jones, Steven S. Foster

01.12.2018 | Debate | Ausgabe 1/2018 Open Access

Working to improve the management of sarcoma patients across Europe: a policy checklist

Bernd Kasper, Estelle Lecointe-Artzner, Suzanne Wait, Shannon Boldon, Roger Wilson, Alessandro Gronchi, Claudia Valverde, Mikael Eriksson, Sarah Dumont, Nora Drove, Athanasia Kanli, Markus Wartenberg

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

High OX40 expression in recurrent ovarian carcinoma is indicative for response to repeated chemotherapy

Michaela Ramser, Simone Eichelberger, Silvio Däster, Benjamin Weixler, Marko Kraljević, Robert Mechera, Athanasios Tampakis, Tarik Delko, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano, Raoul A. Droeser, Gad Singer

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Active DNA end processing in micronuclei of ovarian cancer cells

Zizhi Tang, Juan Yang, Xin Wang, Ming Zeng, Jing Wang, Ao Wang, Mingcai Zhao, Liandi Guo, Cong Liu, Dehua Li, Jie Chen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Outcomes of pathologic stage T3a renal cell carcinoma up-staged from small renal tumor: emphasis on partial nephrectomy

Hakmin Lee, Minseung Lee, Sang Eun Lee, Seok-Soo Byun, Hyeon Hoe Kim, Cheol Kwak, Sung Kyu Hong

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Predictive value of dynamic change of haemoglobin levels during therapy on treatment outcomes in patients with Enneking stage IIB extremity osteosarcoma

Jian Tu, Lili Wen, Zijun Huo, Bo Wang, Yongqian Wang, Hongyi Liao, Weihai Liu, Xian Zhong, Jianqiu Kong, Mengqi Wang, Gang Huang, Junqiang Yin, Xianbiao Xie, Jingnan Shen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Helicase-like transcription factor expression is associated with a poor prognosis in Non-Small-Cell Lung Cancer (NSCLC)

Ludovic Dhont, Melania Pintilie, Ethan Kaufman, Roya Navab, Shirley Tam, Arsène Burny, Frances Shepherd, Alexandra Belayew, Ming-Sound Tsao, Céline Mascaux

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas

Pilar López-Nieva, Pablo Fernández-Navarro, Concepción Vaquero-Lorenzo, María Villa-Morales, Osvaldo Graña-Castro, María Ángeles Cobos-Fernández, José Luis López-Lorenzo, Pilar Llamas, Laura González-Sanchez, Isabel Sastre, Marina Pollan, Marcos Malumbres, Javier Santos, José Fernández-Piqueras

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

EP3 (prostaglandin E2 receptor 3) expression is a prognostic factor for progression-free and overall survival in sporadic breast cancer

Anna Semmlinger, Viktoria von Schoenfeldt, Verena Wolf, Alexandra Meuter, Theresa Maria Kolben, Thomas Kolben, Christine Zeder-Goess, Florian Weis, Julia Gallwas, Rachel Wuerstlein, Kerstin Hermelink, Elisa Schmoeckel, Nadia Harbeck, Doris Mayr, Sven Mahner, Udo Jeschke, Nina Ditsch

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The regulation of combined treatment-induced cell death with recombinant TRAIL and bortezomib through TRAIL signaling in TRAIL-resistant cells

Sunhyo Ryu, Yun Jeong Ahn, Chakeong Yoon, Jeong Hwan Chang, Yoonkyung Park, Tae-Hyoung Kim, Amanda R. Howland, Cheryl A. Armstrong, Peter I. Song, Ae Ran Moon

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Loss of ZG16 is associated with molecular and clinicopathological phenotypes of colorectal cancer

Hui Meng, Wencai Li, Lisa A. Boardman, Liang Wang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Valproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal

Muyun Wei, Shaowei Mao, Guoliang Lu, Liang Li, Xiaopeng Lan, Zhongxian Huang, Yougen Chen, Miaoqing Zhao, Yueran Zhao, Qinghua Xia

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Medical expenses of urban Chinese patients with stomach cancer during 2002–2011: a hospital-based multicenter retrospective study

Xiao-Jie Sun, Ju-Fang Shi, Lan-Wei Guo, Hui-Yao Huang, Neng-Liang Yao, Ji-Yong Gong, Ya-Wen Sun, Guo-Xiang Liu, A-Yan Mao, Xian-Zhen Liao, Ya-Na Bai, Jian-Song Ren, Xin-Yu Zhu, Jin-Yi Zhou, Ling Mai, Bing-Bing Song, Yu-Qin Liu, Lin Zhu, Ling-Bin Du, Qi Zhou, Xiao-Jing Xing, Pei-An Lou, Xiao-Hua Sun, Xiao Qi, Yuanzheng Wang, Rong Cao, Ying Ren, Li Lan, Kai Zhang, Jie He, Jia-Lin Wang, Min Dai, The listed authors are on behalf of the Health Economic Evaluation Working Group, Cancer Screening Program in Urban China (CanSPUC)

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The oncogenic effects of HES1 on salivary adenoid cystic carcinoma cell growth and metastasis

Xiao-Yu Huang, Rui-Huan Gan, Jian Xie, Lin She, Yong Zhao, Lin-Can Ding, Bo-Hua Su, Da-Li Zheng, You-Guang Lu

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Sepsis increases perioperative metastases in a murine model

Lee-Hwa Tai, Abhirami A. Ananth, Rashmi Seth, Almohanad Alkayyal, Jiqing Zhang, Christiano Tanese de Souza, Phillip Staibano, Michael A. Kennedy, Rebecca C. Auer

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effect of metformin use on the risk and prognosis of endometrial cancer: a systematic review and meta-analysis

Danxia Chu, Jie Wu, Kaili Wang, Mengling Zhao, Chunfang Wang, Liuxia Li, Ruixia Guo

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Salivary extracellular vesicle-associated miRNAs as potential biomarkers in oral squamous cell carcinoma

Chiara Gai, Francesco Camussi, Roberto Broccoletti, Alessio Gambino, Marco Cabras, Luca Molinaro, Stefano Carossa, Giovanni Camussi, Paolo G. Arduino

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Predictive values of upper gastrointestinal cancer alarm symptoms in the general population: a nationwide cohort study

Sanne Rasmussen, Peter Fentz Haastrup, Kirubakaran Balasubramaniam, René DePont Christensen, Jens Søndergaard, Dorte Ejg Jarbøl

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Small cell and non small cell lung cancer form metastasis on cellular 4D lung model

Dhruva K. Mishra, Ross A. Miller, Kristi A. Pence, Min P. Kim

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for the treatment of malignant mesothelioma

Urs Giger-Pabst, Cédric Demtröder, Thomas A. Falkenstein, Mehdi Ouaissi, Thorsten O. Götze, Günther A. Rezniczek, Clemens B. Tempfer

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prognostic value of systemic inflammatory markers in ovarian Cancer: a PRISMA-compliant meta-analysis and systematic review

Ying Zhu, Sanqin Zhou, Yang Liu, Lingyun Zhai, Xiwen Sun

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Improving quality of life through the routine use of the patient concerns inventory for head and neck cancer patients: a cluster preference randomized controlled trial

Simon N. Rogers, Derek Lowe, Cher Lowies, Seow Tien Yeo, Christine Allmark, Dominic Mcavery, Gerald M. Humphris, Robert Flavel, Cherith Semple, Steven J. Thomas, Anastasios Kanatas

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Dietary patterns, BCMO1 polymorphisms, and primary lung cancer risk in a Han Chinese population: a case-control study in Southeast China

Fei He, Ren-dong Xiao, Tao Lin, Wei-min Xiong, Qiu-ping Xu, Xu Li, Zhi-qiang Liu, Bao-chang He, Zhi-jian Hu, Lin Cai

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Incidence, pattern and prognosis of brain metastases in patients with metastatic triple negative breast cancer

Jia Jin, Yu Gao, Jian Zhang, Leiping Wang, Biyun Wang, Jun Cao, Zhimin Shao, Zhonghua Wang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre study

Veronika Seebacher, Stephan Polterauer, Alexander Reinthaller, Heinz Koelbl, Regina Achleitner, Astrid Berger, Nicole Concin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Radiosensitization of clioquinol and zinc in human cancer cell lines

Shan Lu, Yuan Ke, Chaoyan Wu, Yahua Zhong, Conghua Xie, Yunfeng Zhou, Fuxiang Zhou, Haijun Yu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Survival after recurrence in patients with gastric cancer who receive S-1 adjuvant chemotherapy: exploratory analysis of the ACTS-GC trial

Seiji Ito, Yasuo Ohashi, Mitsuru Sasako

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Evaluation of PET and laparoscopy in STagIng advanced gastric cancer: a multicenter prospective study (PLASTIC-study)

H. J. F. Brenkman, E. C. Gertsen, E. Vegt, R. van Hillegersberg, M. I. van Berge Henegouwen, S. S. Gisbertz, M. D. P. Luyer, G. A. P. Nieuwenhuijzen, J. J. B. van Lanschot, S. M. Lagarde, W. O. de Steur, H. H. Hartgrink, J. H. M. B. Stoot, K. W. E. Hulsewe, E. J. Spillenaar Bilgen, M. J. van Det, E. A. Kouwenhoven, D. L. van der Peet, F. Daams, J. W. van Sandick, N. C. T. van Grieken, J. Heisterkamp, B. van Etten, J. W. Haveman, J. P. Pierie, F. Jonker, A. Y. Thijssen, E. J. T. Belt, P. van Duijvendijk, E. Wassenaar, H. W. M. van Laarhoven, F. J. Wessels, N. Haj Mohammad, H. F. van Stel, G. W. J. Frederix, P. D. Siersema, J. P. Ruurda, on behalf of the PLASTIC Study Group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Stereotactic body radiation therapy as an effective and safe treatment for small hepatocellular carcinoma

Tao Zhang, Jing Sun, Weiping He, Huan Li, Junjie Piao, Huijun Xu, Xuezhang Duan

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Genetic variants in ATM, H2AFX and MRE11 genes and susceptibility to breast cancer in the polish population

Marta Podralska, Iwona Ziółkowska-Suchanek, Magdalena Żurawek, Agnieszka Dzikiewicz-Krawczyk, Ryszard Słomski, Jerzy Nowak, Agnieszka Stembalska, Karolina Pesz, Maria Mosor

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Retrospective analysis of the impact of anthracycline dose reduction and chemotherapy delays on the outcomes of early breast cancer molecular subtypes

Sigita Liutkauskiene, Saulius Grizas, Kristina Jureniene, Jorune Suipyte, Akvile Statnickaite, Elona Juozaityte

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

The PiGeOn project: protocol of a longitudinal study examining psychosocial and ethical issues and outcomes in germline genomic sequencing for cancer

Megan Best, Ainsley J. Newson, Bettina Meiser, Ilona Juraskova, David Goldstein, Kathy Tucker, Mandy L. Ballinger, Dominique Hess, Timothy E. Schlub, Barbara Biesecker, Richard Vines, Kate Vines, David Thomas, Mary-Anne Young, Jacqueline Savard, Chris Jacobs, Phyllis Butow

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Chemotherapy for metastatic colon cancer: No effect on survival when the dose is reduced due to side effects

Stefan Munker, Michael Gerken, Petra Fest, Claudia Ott, Elisabeth Schnoy, Stefan Fichtner-Feigl, Philipp Wiggermann, Martin Vogelhuber, Wolfgang Herr, Christian Stroszczynski, Hans Jürgen Schlitt, Matthias Evert, Michael Reng, Monika Klinkhammer-Schalke, Andreas Teufel

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

The COSMAM TRIAL a prospective cohort study of quality of life and cosmetic outcome in patients undergoing breast conserving surgery

Coriene J. L. M. Catsman, Martinus A. Beek, Adri C. Voogd, Paul G. H. Mulder, Ernest J. T. Luiten

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Treatment of pancreatic ductal adenocarcinoma with tumor antigen specific-targeted delivery of paclitaxel loaded PLGA nanoparticles

Shu-ta Wu, Anthony J. Fowler, Corey B. Garmon, Adam B. Fessler, Joshua D. Ogle, Kajal R. Grover, Bailey C. Allen, Chandra D. Williams, Ru Zhou, Mahboubeh Yazdanifar, Craig A. Ogle, Pinku Mukherjee

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

First case of AML with rare chromosome translocations: a case report of twins

Lin Wang, Yanhua Sun, Yanli Sun, Lingbin Meng, Xin Xu

01.12.2018 | Study protocol | Ausgabe 1/2018 Open Access

Cost of Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS): prospective cohort study protocol

Irene Teo, Ratna Singh, Chetna Malhotra, Semra Ozdemir, Rebecca A. Dent, Nesaretnam Barr Kumarakulasinghe, Wee Lee Yeo, Yin Bun Cheung, Rahul Malhotra, Ravindran Kanesvaran, Alethea Chung Pheng Yee, Noreen Chan, Huei Yaw Wu, Soh Mun Chin, Hum Yin Mei Allyn, Grace Meijuan Yang, Patricia Soek Hui Neo, Nivedita V. Nadkarni, Richard Harding, Eric A. Finkelstein

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Low expression of c-Myc protein predicts poor outcomes in patients with hepatocellular carcinoma after resection

Fei Ji, Zhi-heng Zhang, Yi Zhang, Shun-Li Shen, Qing-Hua Cao, Long-Juan Zhang, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang, Yun-Peng Hua

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Oncological and reproductive outcomes of adenocarcinoma in situ of the cervix managed with the loop electrosurgical excision procedure

Huimin Bai, Jun Liu, Qiuxi Wang, Ying Feng, Tong Lou, Shuzhen Wang, Yue Wang, Mulan Jin, Zhenyu Zhang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer

Chenlu Zhang, Zhi Li, Ling Xu, Xiaofang Che, Ti Wen, Yibo Fan, Ce Li, Shuo Wang, Yu Cheng, Xiaoxun Wang, Xiujuan Qu, Yunpeng Liu

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Radiogenic angiosarcoma of the breast: case report and systematic review of the literature

Askin Dogan, Peter Kern, Beate Schultheis, Günther Häusler, Günther A. Rezniczek, Clemens B. Tempfer

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cost-effectiveness and budget impact analyses of a colorectal cancer screening programme in a high adenoma prevalence scenario using MISCAN-Colon microsimulation model

Arantzazu Arrospide, Isabel Idigoras, Javier Mar, Harry de Koning, Miriam van der Meulen, Myriam Soto-Gordoa, Jose Miguel Martinez-Llorente, Isabel Portillo, Eunate Arana-Arri, Oliver Ibarrondo, Iris Lansdorp-Vogelaar

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Impact of differences in adenoma and proximal serrated polyp detection rate on the long-term effectiveness of FIT-based colorectal cancer screening

Maxime E. S. Bronzwaer, Marjolein J. E. Greuter, Arne G. C. Bleijenberg, Joep E. G. IJspeert, Evelien Dekker, Veerle M. H. Coupé

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity

Catja Freiburghaus, Venera Kuci Emruli, Angelica Johansson, Christian Winther Eskelund, Kirsten Grønbæk, Roger Olsson, Fredrik Ek, Mats Jerkeman, Sara Ek

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Amphotericin B suppresses M2 phenotypes and B7-H1 expression in macrophages to prevent Raji cell proliferation

Jing Zhang, Dongqing Cao, Shuangquan Yu, Lingchao Chen, Daolin Wei, Chang Shen, Lin Zhuang, Qian Wang, Xiaoping Xu, Yin Tong

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Impact of clinical trial participation on survival in patients with castration-resistant prostate cancer: a multi-center analysis

Kyo Chul Koo, Jong Soo Lee, Jong Won Kim, Kyung Suk Han, Kwang Suk Lee, Do Kyung Kim, Yoon Soo Ha, Koon Ho Rha, Sung Joon Hong, Byung Ha Chung

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Reduction of MHC-I expression limits T-lymphocyte-mediated killing of Cancer-initiating cells

Brian J. Morrison, Jason C. Steel, John C. Morris

01.12.2018 | Kolorektales Karzinom | Case report | Ausgabe 1/2018 Open Access

FOLFOX activity in a rare case of metastatic colonic adenocarcinoma of the tongue: a case report

Clizia Zichi, Marco Tampellini, Marcello Tucci, Cristina Sonetto, Chiara Baratelli, Maria P. Brizzi, Giorgio V. Scagliotti

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Putative cancer stem cells may be the key target to inhibit cancer cell repopulation between the intervals of chemoradiation in murine mesothelioma

Licun Wu, Walter Blum, Chang-Qi Zhu, Zhihong Yun, Laszlo Pecze, Mikihiro Kohno, Mei-Lin Chan, Yidan Zhao, Emanuela Felley-Bosco, Beat Schwaller, Marc de Perrot

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comprehensive gene expression analysis of canine invasive urothelial bladder carcinoma by RNA-Seq

Shingo Maeda, Hirotaka Tomiyasu, Masaya Tsuboi, Akiko Inoue, Genki Ishihara, Takao Uchikai, James K. Chambers, Kazuyuki Uchida, Tomohiro Yonezawa, Naoaki Matsuki

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Genes and functions from breast cancer signatures

Shujun Huang, Leigh Murphy, Wayne Xu

01.12.2018 | Case report | Ausgabe 1/2018 Open Access

Computerized tomography findings in calcified signet-ring gastric cancer receiving chemotherapy: a case report

Ting Wang, Zhi-Yong Lu, Xin-Fei Tu, Shui-Hong Zhang, Fang Huang, Long Huang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter

Walter Blum, László Pecze, Janine Wörthmüller Rodriguez, Martine Steinauer, Beat Schwaller

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study

Stephan P. Bauersfeld, Christian S. Kessler, Manfred Wischnewsky, Annette Jaensch, Nico Steckhan, Rainer Stange, Barbara Kunz, Barbara Brückner, Jalid Sehouli, Andreas Michalsen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Investigation of the SLC22A23 gene in laryngeal squamous cell carcinoma

Seda Ekizoglu, Didem Seven, Turgut Ulutin, Jalal Guliyev, Nur Buyru

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized

Morten Beck Rye, Helena Bertilsson, Maria K. Andersen, Kjersti Rise, Tone F. Bathen, Finn Drabløs, May-Britt Tessem

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

SMAD4 and NF1 mutations as potential biomarkers for poor prognosis to cetuximab-based therapy in Chinese metastatic colorectal cancer patients

Zhu Mei, Yang W. Shao, Peinan Lin, Xiaomin Cai, Biao Wang, Yan Ding, Xiangyuan Ma, Xue Wu, Yewei Xia, Dongqin Zhu, Yongqian Shu, Zan Fu, Yanhong Gu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Development of a computational promoter with highly efficient expression in tumors

Shu-Yi Ho, Bo-Hau Chang, Chen-Han Chung, Yu-Ling Lin, Cheng-Hsun Chuang, Pei-Jung Hsieh, Wei-Chih Huang, Nu-Man Tsai, Sheng-Chieh Huang, Yen-Ku Liu, Yu-Chih Lo, Kuang-Wen Liao

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The accuracy of chemotherapy ascertainment among colorectal cancer patients in the surveillance, epidemiology, and end results registry program

Mark A. Healy, Arden M. Morris, Paul Abrahamse, Kevin C. Ward, Ikuko Kato, Christine M. Veenstra

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Incidence trends and patterns of breast cancer in Sri Lanka: an analysis of the national cancer database

Ashan Fernando, Umesh Jayarajah, Saumyakala Prabashani, Eshani A. Fernando, Sanjeewa A. Seneviratne

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Extra-capsular growth of lymph node metastasis correlates with poor prognosis and high SOX9 expression in gastric cancer

Helena Link, Martin Angele, Miriam Schüller, Petra Ganschow, Lena Machetanz, Markus Guba, Jens Werner, Thomas Kirchner, Jens Neumann