BMC Cancer

A novel ferroptosis-related gene signature associated with cell cycle for prognosis prediction in patients with clear cell renal cell carcinoma

• Open Access
• Research

Siteng Chen, Encheng Zhang, Tuanjie Guo, Jialiang Shao, Tao Wang, Ning Zhang, Xiang Wang, Junhua Zheng

Alteration in glycolytic/cholesterogenic gene expression is associated with bladder cancer prognosis and immune cell infiltration

• Open Access
• Research

Yuying Zhang, Baoyi Zhu, Yi Cai, Sihua Zhu, Hongjun Zhao, Xiaoling Ying, Chonghe Jiang, Jianwen Zeng

Metastatic gastroesophageal cancer in older patients – is this patient cohort represented in clinical trials?

• Open Access
• Research

Maeve A. Hennessy, Munzir Hamid, Niamh M. Keegan, Lynda Corrigan, Caitriona Goggin, Nay Myo Oo, Marie Carrigan, David Mockler, Anita O’Donovan, Anne M. Horgan

Construction and validation of the prognostic model for patients with neuroendocrine cervical carcinoma: a competing risk nomogram analysis

• Open Access
• Research

Ai-Guo Jiang, Xu Cai

A2M is a potential core gene in intrahepatic cholangiocarcinoma

• Open Access
• Research

Guanran Zhang, Xuyue Liu, Zhengyang Sun, Xiaoning Feng, Haiyan Wang, Jing Hao, Xiaoli Zhang

Plasma circN4BP2L2 is a promising novel diagnostic biomarker for epithelial ovarian cancer

• Open Access
• Research

Li Ning, Jinghe Lang, Lingying Wu

Serum apolipoprotein B to apolipoprotein A-I ratio is an independent predictor of liver metastasis from locally advanced rectal cancer in patients receiving neoadjuvant chemoradiotherapy plus surgery

• Open Access
• Research

Chen Chen, Wei Yi, Zhi-fan Zeng, Qiao-xuan Wang, Wu Jiang, Yuan-hong Gao, Hui Chang

Mapping psychosocial interventions in familial colorectal cancer: a rapid systematic review

• Open Access
• Research

Andrada Ciucă, Ramona Moldovan, Adriana Băban

High efficacy of PD-1 inhibitor after initial failure of PD-L1 inhibitor in Relapsed/Refractory classical Hodgkin Lymphoma

• Open Access
• Research

Xi Chen, Haiying Kong, Linxiang Luo, Shuiyun Han, Tao Lei, Haifeng Yu, Na Guo, Cong Li, Shuailing Peng, Xiaowu Dong, Haiyan Yang, Meijuan Wu

Prognostic effect of lncRNA SNHG7 on cancer outcome: a meta and bioinformatic analysis

• Open Access
• Research

Yunyuan Zhang, Qingwu Tian, Shifeng Huang, Qing Wang, Hongmei Wu, Qian Dong, Xian Chen

Monitoring of post-transplant MLL-PTD as minimal residual disease can predict relapse after allogeneic HSCT in patients with acute myeloid leukemia and myelodysplastic syndrome

• Open Access
• Research

Jun Kong, Meng-Ge Gao, Ya-Zhen Qin, Yu Wang, Chen-Hua Yan, Yu-Qian Sun, Ying-Jun Chang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang, Xiao-Su Zhao

The blood level of thioredoxin 1 as a supporting biomarker in the detection of breast cancer

• Open Access
• Research article

Youn Ju Lee, Young Kim, Bo Bae Choi, Je Ryong Kim, Hye Mi Ko, Kyoung Hoon Suh, Jin Sun Lee

Landscape of homologous recombination deficiencies in solid tumours: analyses of two independent genomic datasets

• Open Access
• Research

Zhongwu Lai, Matthew Brosnan, Ethan S. Sokol, Mingchao Xie, Jonathan R. Dry, Elizabeth A. Harrington, J. Carl Barrett, Darren Hodgson

PIONEER-Panc: a platform trial for phase II randomized investigations of new and emerging therapies for localized pancreatic cancer

• Open Access
• Study protocol

Julia E. Douglas, Suyu Liu, Junsheng Ma, Robert A. Wolff, Shubham Pant, Anirban Maitra, Eric P. Tamm, Priya Bhosale, Matthew H. G. Katz, Gauri R. Varadhachary, Eugene J. Koay

Optimal surgical treatment for paratesticular leiomyosarcoma: retrospective analysis of 217 reported cases

• Open Access
• Research

Rei Kamitani, Kazuhiro Matsumoto, Toshikazu Takeda, Ryuichi Mizuno, Mototsugu Oya

Fatigue in breast cancer patients on chemotherapy: a cross-sectional study exploring clinical, biological, and genetic factors

• Open Access
• Research

Aline Hajj, Rami Chamoun, Pascale Salameh, Rita Khoury, Roula Hachem, Hala Sacre, Georges Chahine, Joseph Kattan, Lydia Rabbaa Khabbaz

Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and response-adaptive treatment

• Open Access
• Study protocol

Ari J. Rosenberg, Evgeny Izumchenko, Alexander Pearson, Zhen Gooi, Elizabeth Blair, Theodore Karrison, Aditya Juloori, Daniel Ginat, Nicole Cipriani, Mark Lingen, Hillary Sloane, Daniel L. Edelstein, Kirsten Keyser, Johannes Fredebohm, Frank Holtrup, Frederick S. Jones, Daniel Haraf, Nishant Agrawal, Everett E. Vokes

Assessing frequency and clinical outcomes of BRCA mutated ovarian cancer in Saudi women

• Open Access
• Research article

Naela Agha, Bader Alshamsan, Sharifa Al-Farsi, Heba Aly Ateya, Fahad A. Almugbel, Hazem Abdullah Alotaibi, Ayman Omar, Amgad Shahin Mohamed, Hanan Alharthy, Tusneem Elhassan, Hany Salem, Hamed Alhusaini

Prognostic nomogram for patients with unresectable pancreatic cancer treated with gemcitabine plus nab–paclitaxel or FOLFIRINOX: A post–hoc analysis of a multicenter retrospective study in Japan (NAPOLEON study)

• Open Access
• Research article

Taro Shibuki, Toshihiko Mizuta, Mototsugu Shimokawa, Futa Koga, Yujiro Ueda, Junichi Nakazawa, Azusa Komori, Satoshi Otsu, Shiho Arima, Masaru Fukahori, Akitaka Makiyama, Hiroki Taguchi, Takuya Honda, Kenji Mitsugi, Kenta Nio, Yasushi Ide, Norio Ureshino, Tsuyoshi Shirakawa, Taiga Otsuka

Prognostic value of preoperative high-sensitivity modified Glasgow prognostic score in advanced colon cancer: a retrospective observational study

• Open Access
• Research

Kenta Kasahara, Masanobu Enomoto, Ryutaro Udo, Tomoya Tago, Junichi Mazaki, Tetsuo Ishizaki, Tesshi Yamada, Yuichi Nagakawa, Kenji Katsumata, Akihiko Tsuchida

Application of protection motivation theory (PMT) on skin cancer preventive behaviors amongst primary school students in rural areas of Fasa city-Iran

• Open Access
• Research

Ali Khani Jeihooni, Somayeh Bashti, Bahareh Erfanian, Jeyran Ostovarfar, Pooyan Afzali Hasirini

Clinical features as potential prognostic factors in patients treated with nivolumab for highly pretreated metastatic gastric cancer: a multicenter retrospective study

• Open Access
• Research article

Akihiko Sano, Makoto Sohda, Nobuhiro Nakazawa, Yasunari Ubukata, Kengo Kuriyama, Akiharu Kimura, Norimichi Kogure, Hisashi Hosaka, Atsushi Naganuma, Masanori Sekiguchi, Kana Saito, Kyoichi Ogata, Makoto Sakai, Hiroomi Ogawa, Ken Shirabe, Hiroshi Saeki

Pancreatic fibrosis, acinar atrophy and chronic inflammation in surgical specimens associated with survival in patients with resectable pancreatic ductal adenocarcinoma

• Open Access
• Research

Taija Korpela, Ari Ristimäki, Marianne Udd, Tiina Vuorela, Harri Mustonen, Caj Haglund, Leena Kylänpää, Hanna Seppänen

Targeting CD33 for acute myeloid leukemia therapy

• Open Access
• Research article

Jingjing Liu, Jiayin Tong, Haiping Yang

Factors associated with response to compression-based physical therapy for secondary lower limb lymphedema after gynecologic cancer treatment: a multicenter retrospective study

• Open Access
• Research

Masato Yoshihara, Kaoru Kitamura, Satoko Tsuru, Ryoko Shimono, Hiromi Sakuda, Michinori Mayama, Sho Tano, Kaname Uno, Mayu Ohno Ukai, Yasuyuki Kishigami, Hidenori Oguchi, Akio Hirota

Integration of breast cancer care in a middle-income country: learning from Suandok Breast Cancer Network (SBCN)

• Open Access
• Research article

Imjai Chitapanarux, Wimrak Onchan, Panchaporn Wongmaneerung, Areewan Somwangprasert, Nongnuch Bunyoo, Chagkrit Ditsatham, Kirati Watcharachan, Chaiyut Charoentum, Patumrat Sripan, Ausreeya Chumachote, Puttachart Maneesai

The impact of young age (< 40 years) on the outcome of a cohort of patients with primary non-metastatic breast cancer: analysis of 10-year survival of a prospective study

• Open Access
• Research

Youssef Bouferraa, Yolla Haibe, Andrea Chedid, Elio Jabra, Maya Charafeddine, Sally Temraz, Deborah Mukherji, Nagi El Saghir, Ali Shamseddine

A phase IA dose-escalation study of PHI-101, a new checkpoint kinase 2 inhibitor, for platinum-resistant recurrent ovarian cancer

• Open Access
• Study protocol

Soo Jin Park, Suk-Joon Chang, Dong Hoon Suh, Tae Wook Kong, Heekyoung Song, Tae Hun Kim, Jae-Weon Kim, Hee Seung Kim, Sung-Jong Lee

High score of LDH plus dNLR predicts poor survival in patients with HER2-positive advanced breast cancer treated with trastuzumab emtansine

• Open Access
• Research

Liru Li, Lin Ai, Lin Jia, Lei Zhang, Boya Lei, Qingyuan Zhang

Microbiome composition indicate dysbiosis and lower richness in tumor breast tissues compared to healthy adjacent paired tissue, within the same women

• Open Access
• Research article

Maria Valeria Esposito, Bruno Fosso, Marcella Nunziato, Giorgio Casaburi, Valeria D’Argenio, Alessandra Calabrese, Massimiliano D’Aiuto, Gerardo Botti, Graziano Pesole, Francesco Salvatore

Eribulin improved the overall survival from the initiation of first-line chemotherapy for HER2-negative advanced breast cancer: a multicenter retrospective study

• Open Access
• Research article

Shogo Nakamoto, Junichiro Watanabe, Shoichiro Ohtani, Satoshi Morita, Masahiko Ikeda

Significance of the neutrophil-to-lymphocyte ratio in predicting the response to neoadjuvant chemotherapy in extremity osteosarcoma: a multicentre retrospective study

• Open Access
• Research

Haijun Tang, Dehuai Liu, Jili Lu, Juliang He, Shuyu Ji, Shijie Liao, Qingjun Wei, Shenglin Lu, Yun Liu

Correction to: No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter

• Open Access
• Correction

Shiva Sabazade, Christina Herrspiegel, Viktor Gill, Gustav Stålhammar

Secretion of BMP-2 by tumor-associated macrophages (TAM) promotes microcalcifications in breast cancer

• Open Access
• Research

Shuo Wang, Haiyang Jiang, Caiwei Zheng, Ming Gu, Xinyu Zheng

Optimizing the treatment mode for de novo metastatic nasopharyngeal carcinoma with bone-only metastasis

• Open Access
• Research

Cheng Lin, Sheng Lin, Lili Zhu, Shaojun Lin, Jianji Pan, Yun Xu

Trastuzumab and fulvestrant combination therapy for women with advanced breast cancer positive for hormone receptor and human epidermal growth factor receptor 2: a retrospective single-center study

• Open Access
• Research

Yukinori Ozaki, Yosuke Aoyama, Jun Masuda, Lina Inagaki, Saori Kawai, Tomoko Shibayama, Tetsuyo Maeda, Mami Kurata, Kazuyo Yoshida, Sumito Saeki, Mari Hosonaga, Ippei Fukada, Fumikata Hara, Takayuki Kobayashi, Kokoro Kobayashi, Satoshi Miyake, Toshimi Takano, Takayuki Ueno, Shinji Ohno

Mediators of screening uptake in a colorectal cancer screening intervention among Hispanics

• Open Access
• Research

Navkiran K. Shokar, Jennifer Salinas, Alok Dwivedi

The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma

• Open Access
• Research

Georgia Sofia Karachaliou, Rached Alkallas, Sarah B. Carroll, Chongshan Caressi, Danny Zakria, Nirali M. Patel, Dimitri G. Trembath, Jennifer A. Ezzell, Guillaume J. Pegna, Paul B. Googe, Jonathan P. Galeotti, Fatih Ayvali, Frances A. Collichio, Carrie B. Lee, David W. Ollila, Margaret L. Gulley, Douglas B. Johnson, Kevin B. Kim, Ian R. Watson, Stergios J. Moschos

Restricting tumor lactic acid metabolism using dichloroacetate improves T cell functions

• Open Access
• Research

Hosein Rostamian, Mohammad Khakpoor-Koosheh, Leila Jafarzadeh, Elham Masoumi, Keyvan Fallah-Mehrjardi, Mohammad Javad Tavassolifar, John M. Pawelek, Hamid Reza Mirzaei, Jamshid Hadjati

Local detection of microvessels in IDH-wildtype glioblastoma using relative cerebral blood volume: an imaging marker useful for astrocytoma grade 4 classification

• Open Access
• Research article

María del Mar Álvarez-Torres, Elies Fuster-García, Javier Juan-Albarracín, Gaspar Reynés, Fernando Aparici-Robles, Jaime Ferrer-Lozano, Juan Miguel García-Gómez

OncoSNIPE® Study Protocol, a study of molecular profiles associated with development of resistance in solid cancer patients

• Open Access
• Study protocol

Sébastien Vachenc, Jessica Gobbo, Sarah El Moujarrebe, Isabelle Desmoulins, Marine Gilabert, Michelle Beau-Faller, Emmanuel Mitry, Nicolas Girard, Aurélie Bertaut, Nelson Dusetti, Juan L. Iovanna, Rahima Yousfi, Fabien Pierrat, Roman Bruno, Adèle Cueff, Romain Boidot, Philippe Genne

Roles of extended human papillomavirus genotyping and multiple infections in early detection of cervical precancer and cancer and HPV vaccination

• Open Access
• Research

Fangbin Song, Peisha Yan, Xia Huang, Chun Wang, Hui Du, Xinfeng Qu, Ruifang Wu

Validation of the efficacy of the NUTRISCORE for the nutritional screening of cancer patients in China

• Open Access
• Research article

Junren Kang, Hailong Li, Xiaodong Shi, Enling Ma, Wei Chen

Identification of an at-risk subpopulation with high immune infiltration based on the peroxisome pathway and TIM3 in colorectal cancer

• Open Access
• Research

Jinwen Yin, Hao Wang, Yuntian Hong, Anli Ren, Haizhou Wang, Lan Liu, Qiu Zhao

A novel prognostic index for sporadic Burkitt lymphoma in adult patients: a real-word multicenter study

• Open Access
• Research

Mei-ting Chen, Fei Pan, Yung-chang Chen, Wei Zhang, Hui-juan Lv, Zhao Wang, Huang-ming Hong, Xiao-jie Fang, Ya-wen Wang, Tao Pan, Li-qun Zou, Hong-qiang Guo, Ke Xie, Li-min Chen, Xiao-qian Li, Yu-yi Yao, Ze-geng Chen, Hua-wei Weng, Xu-dong Li, Yuan-yuan Shen, Hui Zhou, Hong-wei Xue, Hui-lai Zhang, He Huang, Tong-yu Lin

Digital gene expression analysis of NSCLC-patients reveals strong immune pressure, resulting in an immune escape under immunotherapy

• Open Access
• Research

Michael Wessolly, Susann Stephan-Falkenau, Anna Streubel, Marcel Wiesweg, Sabrina Borchert, Elena Mairinger, Jens Kollmeier, Henning Reis, Torsten Bauer, Kurt Werner Schmid, Thomas Mairinger, Martin Schuler, Fabian D. Mairinger

Preemptive pharmacogenetic testing to guide chemotherapy dosing in patients with gastrointestinal malignancies: a qualitative study of barriers to implementation

• Open Access
• Research

Kelsey S. Lau-Min, Lisa A. Varughese, Maria N. Nelson, Christine Cambareri, Nandi J. Reddy, Randall A. Oyer, Ursina R. Teitelbaum, Sony Tuteja

Colorectal Cancer in North-Eastern Iran: a retrospective, comparative study of early-onset and late-onset cases based on data from the Iranian hereditary colorectal cancer registry

• Open Access
• Research

Benyamin Hoseini, Zahra Rahmatinejad, Ladan Goshayeshi, Robert Bergquist, Amin Golabpour, Kamran Ghaffarzadegan, Fatemeh Rahmatinejad, Reza Darrudi, Saeid Eslami

Iodine-125 seed represses the growth and facilitates the apoptosis of colorectal cancer cells by suppressing the methylation of miR-615 promoter

• Open Access
• Research

Fenghai Ren, Baojun Li, Chao Wang, Yanbo Wang, Binbin Cui

Characterization of surface markers on extracellular vesicles isolated from lymphatic exudate from patients with breast cancer

• Open Access
• Research

Karin Ekström, Rossella Crescitelli, Hafsteinn Ingi Pétursson, Junko Johansson, Cecilia Lässer, Roger Olofsson Bagge

Checkpoint inhibitors in metastatic gastric and GEJ cancer: a multi-institutional retrospective analysis of real-world data in a Western cohort

• Open Access
• Research article

Verena Schlintl, Florian Huemer, Gabriel Rinnerthaler, Thomas Melchardt, Thomas Winder, Patrick Reimann, Jakob Riedl, Arno Amann, Wolfgang Eisterer, Franz Romeder, Gudrun Piringer, Aysegül Ilhan-Mutlu, Ewald Wöll, Richard Greil, Lukas Weiss

Meta-analysis of health state utility values measured by EuroQol 5-dimensions (EQ5D) questionnaire in Chinese women with breast cancer

• Open Access
• Research article

Tamlyn Rautenberg, Brent Hodgkinson, Ute Zerwes, Martin Downes

Exercise-based dysphagia rehabilitation for adults with oesophageal cancer: a systematic review

• Open Access
• Research article

Anna Gillman, Michelle Hayes, Greg Sheaf, Margaret Walshe, John V. Reynolds, Julie Regan

Variable roles of interleukin-17F in different cancers

• Open Access
• Research

Tiina Mikkola, Rabeia Almahmoudi, Tuula Salo, Ahmed Al-Samadi

Anti-PD-1 combined sorafenib versus anti-PD-1 alone in the treatment of advanced hepatocellular cell carcinoma: a propensity score-matching study

• Open Access
• Research

San-Chi Chen, Yi-Hsiang Huang, Ming-Huang Chen, Yi-Ping Hung, Rheun-Chuan Lee, Yu-Yun Shao, Yee Chao

Nanoparticle albumin-bound paclitaxel and PD-1 inhibitor (sintilimab) combination therapy for soft tissue sarcoma: a retrospective study

• Open Access
• Research

Zhichao Tian, Shuping Dong, Yang Yang, Shilei Gao, Yonghao Yang, Jinpo Yang, Peng Zhang, Xin Wang, Weitao Yao

The mediator role of resilience between psychological predictors and health-related quality of life in breast cancer survivors: a cross-sectional study

• Open Access
• Research

Kaina Zhou, Fan Ning, Wen Wang, Xiaomei Li

The non-fatal burden of cancer in Belgium, 2004–2019: a nationwide registry-based study

• Open Access
• Research

Vanessa Gorasso, Geert Silversmit, Marc Arbyn, Astrid Cornez, Robby De Pauw, Delphine De Smedt, Ian Grant, Grant M. A. Wyper, Brecht Devleesschauwer, Niko Speybroeck

Clinical significance of metabolism-related genes and FAK activity in ovarian high-grade serous carcinoma

• Open Access
• Research

Masakazu Sato, Sho Sato, Daisuke Shintani, Mieko Hanaoka, Aiko Ogasawara, Maiko Miwa, Akira Yabuno, Akira Kurosaki, Hiroyuki Yoshida, Keiichi Fujiwara, Kosei Hasegawa

Routine use of low-dose glucarpidase following high-dose methotrexate in adult patients with CNS lymphoma: an open-label, multi-center phase I study

• Open Access
• Research

Lauren R. Schaff, Mina Lobbous, Dean Carlow, Ryan Schofield, Igor T. Gavrilovic, Alexandra M. Miller, Jacqueline B. Stone, Anna F. Piotrowski, Ugur Sener, Anna Skakodub, Edward P. Acosta, Kevin J. Ryan, Ingo K. Mellinghoff, Lisa M. DeAngelis, Louis B. Nabors, Christian Grommes

Prognostic significance of long non-coding RNA five prime to XIST in various cancers

• Open Access
• Research

Jian Zhou, Junjie Chen, Ziyuan Chen, Gen Wu, Zhen Zhou, Tong Wu, Wanchun Wang, Yingquan Luo, Tang Liu

An exploration of immunohistochemistry-based prognostic markers in patients undergoing curative resections for colon cancer

• Open Access
• Research

Astrid Louise Bjørn Bennedsen, Luyi Cai, Rune Petring Hasselager, Aysun Avci Özcan, Khadra Bashir Mohamed, Jens Ole Eriksen, Susanne Eiholm, Michael Bzorek, Anne-Marie Kanstrup Fiehn, Thomas Vauvert F. Hviid, Ismail Gögenur

Inflammation-scores as prognostic markers of overall survival in lung cancer: a register-based study of 6,210 Danish lung cancer patients

• Open Access
• Research

Anne Winther-Larsen, Ninna Aggerholm-Pedersen, Birgitte Sandfeld-Paulsen

Neutrophil-to-lymphocyte ratio as a prognostic factor for patients with metastatic or recurrent breast cancer treated using capecitabine: a retrospective study

• Open Access
• Research

Shigemasa Takamizawa, Tatsunori Shimoi, Natsuko Satomi-Tsushita, Shu Yazaki, Toshihiro Okuya, Yuki Kojima, Hitomi Sumiyoshi-Okuma, Tadaaki Nishikawa, Maki Tanioka, Kazuki Sudo, Emi Noguchi, Kan Yonemori

Polygenic risk prediction models for colorectal cancer: a systematic review

• Open Access
• Research

Michele Sassano, Marco Mariani, Gianluigi Quaranta, Roberta Pastorino, Stefania Boccia

Health-related quality of life in women with breast cancer: a review of measures

• Open Access
• Research article

Maribel Salas, Margaret Mordin, Colleen Castro, Zahidul Islam, Nora Tu, Michelle D. Hackshaw

THUNDER 2: THeragnostic Utilities for Neoplastic DisEases of the Rectum by MRI guided radiotherapy

• Open Access
• Study protocol

Giuditta Chiloiro, Davide Cusumano, Luca Boldrini, Angela Romano, Lorenzo Placidi, Matteo Nardini, Elisa Meldolesi, Brunella Barbaro, Claudio Coco, Antonio Crucitti, Roberto Persiani, Lucio Petruzziello, Riccardo Ricci, Lisa Salvatore, Luigi Sofo, Sergio Alfieri, Riccardo Manfredi, Vincenzo Valentini, Maria Antonietta Gambacorta

Core promoter mutation contributes to abnormal gene expression in bladder cancer

• Open Access
• Research

Teng Huang, Jiaheng Li, San Ming Wang

Women’s health behaviour change after receiving breast cancer risk estimates with tailored screening and prevention recommendations

• Open Access
• Research

Linda Rainey, Daniëlle van der Waal, Louise S. Donnelly, Jake Southworth, David P. French, D. Gareth Evans, Mireille J. M. Broeders

An estimate of rate of deviation from NCCN guideline recommendations for central nervous system imaging in trials forming basis for drug approval in first line advanced non-small cell lung cancer (NSCLC)

• Open Access
• Research

John Sharp, Vinay Prasad

Comparison of surgical outcomes and prognosis between wedge resection and simple Segmentectomy for GGO diameter between 2 cm and 3 cm in non-small cell lung cancer: a multicenter and propensity score matching analysis

• Open Access
• Research

Yaodong Zhou, Tao Yu, Yixin Zhang, Liqiang Qian, Qing Xia

SMAD4–201 transcript as a putative biomarker in colorectal cancer

• Open Access
• Research

Tamara Babic, Sandra Dragicevic, Marko Miladinov, Zoran Krivokapic, Aleksandra Nikolic

Microsatellite instability is biased in Amsterdam II-defined Lynch-related cancer cases with family history but is rare in other cancers: a summary of 1000 analyses

• Open Access
• Research

Hiroyuki Matsubayashi, Satomi Higashigawa, Yoshimi Kiyozumi, Takuma Oishi, Keiko Sasaki, Hirotoshi Ishiwatari, Kenichiro Imai, Kinichi Hotta, Yohei Yabuuchi, Kazuma Ishikawa, Tatsunori Satoh, Hiroyuki Ono, Akiko Todaka, Takeshi Kawakami, Hiromichi Shirasu, Hirofumi Yasui, Teichi Sugiura, Katsuhiko Uesaka, Hiroyasu Kagawa, Akio Shiomi, Nobuhiro Kado, Yasuyuki Hirashima, Yoshio Kiyohara, Etsuro Bando, Masashi Niwakawa, Seiichiro Nishimura, Takeshi Aramaki, Nobuaki Mamesaya, Hirotsugu Kenmotsu, Yasue Horiuchi, Masakuni Serizawa

Two novel prognostic models for ovarian cancer respectively based on ferroptosis and necroptosis

• Open Access
• Research

Yang Li, Xiaojin Gong, Tongxiu Hu, Yurong Chen

NSAID use and unnatural deaths after cancer diagnosis: a nationwide cohort study in Sweden

• Open Access
• Research

Qing Shen, Arvid Sjölander, Erica K. Sloan, Adam K. Walker, Katja Fall, Unnur Valdimarsdottir, Pär Sparén, Karin E. Smedby, Fang Fang

The role of liver resection in metastatic nephroblastoma: a systematic review and Meta-regression analysis

• Open Access
• Research

Juri Fuchs, Anastasia Murtha-Lemekhova, Markus Kessler, Patrick Günther, Katrin Hoffmann

High expression of S100A2 predicts poor prognosis in patients with endometrial carcinoma

• Open Access
• Research

Qinzhen Zhang, Tianxiang Xia, Chenxiang Qi, Jun Du, Chunping Ye

HoSAGE: sarcopenia in older patient with intermediate / high-risk prostate cancer, prevalence and incidence after androgen deprivation therapy: study protocol for a cohort trial

• Open Access
• Study protocol

Anne-Laure Couderc, Patrick Villani, Julie Berbis, Emilie Nouguerède, Dominique Rey, Dominique Rossi, Éric Lechevallier, Delphine Badinand, Cyrille Bastide, Gilles Karsenty, Romain Boissier, Kahena Amichi, Xavier Muracciole

Radiosynthesis of a novel antisense imaging probe targeting LncRNA HOTAIR in malignant glioma

• Open Access
• Research

Jiongyu Ren, Xiyuan Zhang, Jiang Cao, Jiali Tian, Jin Luo, Yaping Yu, Fengkui Wang, Qian Zhao

Modulation of chemoimmunotherapy efficacy in non-small cell lung cancer by sex and histology: a real-world, patient-level analysis

• Open Access
• Research

Stephanie Tuminello, Naomi Alpert, Rajwanth R. Veluswamy, Arvind Kumar, Jorge E. Gomez, Raja Flores, Emanuela Taioli

Alpha-1 antitrypsin deficiency and risk of lung cancer in never-smokers: a multicentre case–control study

• Open Access
• Research

Ramón Antonio Tubío-Pérez, María Torres-Durán, María Esmeralda García-Rodríguez, Cristina Candal-Pedreira, Julia Rey-Brandariz, Mónica Pérez-Ríos, Juan Barros-Dios, Alberto Fernández-Villar, Alberto Ruano-Raviña

Treatment outcomes of esophageal cancer in Eastern Africa: protocol of a multi-center, prospective, observational, open cohort study

• Open Access
• Study protocol

Geoffrey C. Buckle, Alita Mrema, Michael Mwachiro, Yona Ringo, Msiba Selekwa, Gift Mulima, Fatma F. Some, Blandina T. Mmbaga, Gita N. Mody, Li Zhang, Alan Paciorek, Larry Akoko, Paul Ayuo, Stephen Burgert, Elizabeth Bukusi, Anthony Charles, Winnie Chepkemoi, Gladys Chesumbai, Bongani Kaimila, Aida Kenseko, Kitembo Salum Kibwana, David Koech, Caren Macharia, Ezekiel N. Moirana, Beatrice Paul Mushi, Alex Mremi, Julius Mwaiselage, Ally Mwanga, Jerry Ndumbalo, Gissela Nvakunga, Mamsau Ngoma, Margaret Oduor, Mark Oloo, Jesse Opakas, Robert Parker, Saruni Seno, Ande Salima, Furaha Servent, Andrew Wandera, Kate D. Westmoreland, Russell E. White, Brittney Williams, Elia J. Mmbaga, Katherine Van Loon

Overexpression of PFKFB3 promotes cell glycolysis and proliferation in renal cell carcinoma

• Open Access
• Research

Jun Li, Shiqiang Zhang, Dingzhun Liao, Qian Zhang, Chujie Chen, Xiangwei Yang, Donggen Jiang, Jun Pang

Identification of an ACK1/TNK2-based prognostic signature for colon cancer to predict survival and inflammatory landscapes

• Open Access
• Research

Defeng Kong, Guoliang Li, Zhenrong Yang, Shujun Cheng, Wen Zhang, Lin Feng, Kaitai Zhang

Whole genome deep sequencing analysis of cell-free DNA in samples with low tumour content

• Open Access
• Research article

Devika Ganesamoorthy, Alan James Robertson, Wenhan Chen, Michael B. Hall, Minh Duc Cao, Kaltin Ferguson, Sunil R. Lakhani, Katia Nones, Peter T. Simpson, Lachlan J. M. Coin

Deep learning identified glioblastoma subtypes based on internal genomic expression ranks

• Open Access
• Research

Xing-gang Mao, Xiao-yan Xue, Ling Wang, Wei Lin, Xiang Zhang

Comparative analysis of the value of amide proton transfer-weighted imaging and diffusion kurtosis imaging in evaluating the histological grade of cervical squamous carcinoma

• Open Access
• Research

Mengyan Hou, Kai Song, Jipeng Ren, Kaiyu Wang, Jinxia Guo, Yongchao Niu, Zhenyu Li, Dongming Han

Extracellular vesicles mediated proinflammatory macrophage phenotype induced by radiotherapy in cervical cancer

• Open Access
• Research

Junli Ren, Lili Li, Baofeng Yu, Enwei Xu, Naiping Sun, Xiaoning Li, Zihan Xing, Xiaodong Han, Yaqin Cui, Xiaoyan Wang, Xiaoxue Zhang, Guoliang Wang

Metabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies

• Open Access
• Research

Golnoosh Goodarzi, Hadis Mozaffari, Tahereh Raeisi, Fatemeh Mehravar, Bahman Razi, Maryam Lafzi Ghazi, Nazila Garousi, Shahab Alizadeh, Parisa Janmohammadi

Effects of an oral mucosa protective formulation on chemotherapy- and/or radiotherapy-induced oral mucositis: a prospective study

• Open Access
• Research

Takao Ueno, Wakako Yatsuoka, Hiroto Ishiki, Kanako Miyano, Yasuhito Uezono

Statin use is associated with the reduction in hepatocellular carcinoma recurrence after liver surgery

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Elias Khajeh, Arash Dooghaie Moghadam, Pegah Eslami, Sadeq Ali-Hasan-Al-Saegh, Ali Ramouz, Saeed Shafiei, Omid Ghamarnejad, Sepehr Abbasi Dezfouli, Christian Rupp, Christoph Springfeld, Carlos Carvalho, Pascal Probst, Seyed Mostafa Mousavizadeh, Arianeb Mehrabi

Fibrinogen/albumin ratio as a promising predictor of platinum response and survival in ovarian clear cell carcinoma

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Wei Chen, Boer Shan, Shuling Zhou, Huijuan Yang, Shuang Ye

Serum cholinesterase may independently predict prognosis in non-small-cell lung cancer

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Hailiang Ran, Jie Ma, Le Cai, Hai Zhou, Zhongqin Yuan, Ying Chen, Wei Chang, Yunchao Huang, Yuanyuan Xiao

Standardization of evaluation method and prognostic significance of histological response to preoperative chemotherapy in high-grade non-round cell soft tissue sarcomas

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Yoshinao Oda, Kazuhiro Tanaka, Takanori Hirose, Tadashi Hasegawa, Nobuyuki Hiruta, Masanori Hisaoka, Masato Yoshimoto, Hiroshi Otsuka, Hirofumi Bekki, Takeaki Ishii, Makoto Endo, Toshiyuki Kunisada, Toru Hiruma, Hiroyuki Tsuchiya, Hirohisa Katagiri, Yoshihiro Matsumoto, Akira Kawai, Robert Nakayama, Hiroyuki Kawashima, Satoshi Takenaka, Makoto Emori, Munenori Watanuki, Yukihiro Yoshida, Takeshi Okamoto, Junki Mizusawa, Haruhiko Fukuda, Toshifumi Ozaki, Yukihide Iwamoto, Takayuki Nojima

Dietary patterns and severity of symptom with the risk of esophageal squamous cell carcinoma and its histological precursor lesions in China: a multicenter cross-sectional latent class analysis

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Zhaoping Zang, Yong Liu, Jialin Wang, Yuqin Liu, Shaokai Zhang, Yongzhen Zhang, Liwei Zhang, Deli Zhao, Fugang Liu, Lina Chao, Xinzheng Wang, Chunli Zhang, Guohui Song, Zhiyi Zhang, Youpeng Li, Zheng Yan, Yongxiu Wen, Yinyin Ge, Chen Niu, Wei Feng, Rena Nakyeyune, Yi Shen, Yi Shao, Xiuhua Guo, Aiming Yang, Fen Liu, Guiqi Wang

Dose-escalation by hypofractionated simultaneous integrated boost IMRT in unresectable stage III non-small-cell lung cancer

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Qin Zhang, Xu-Wei Cai, Wen Feng, Wen Yu, Xiao-Long Fu

Correction to: Guy’s and St Thomas NHS Foundation active surveillance prostate cancer cohort: a characterisation of a prostate cancer active surveillance database

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Salonee Shah, Kerri Beckmann, Mieke Van Hemelrijck, Ben Challacombe, Rick Popert, Prokar Dasgupta, Jonah Rusere, Grace Zisengwe, Oussama Elhage, Aida Santaolalla

Adverse effects in hematologic malignancies treated with chimeric antigen receptor (CAR) T cell therapy: a systematic review and Meta-analysis

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Wenjing Luo, Chenggong Li, Yinqiang Zhang, Mengyi Du, Haiming Kou, Cong Lu, Heng Mei, Yu Hu

The MITRE trial protocol: a study to evaluate the microbiome as a biomarker of efficacy and toxicity in cancer patients receiving immune checkpoint inhibitor therapy

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Nicola A. Thompson, Grant D. Stewart, Sarah J. Welsh, Gary J. Doherty, Matthew J. Robinson, B. Anne Neville, Kevin Vervier, Simon R. Harris, David J. Adams, Katy Dalchau, David Bruce, Nikolaos Demiris, Trevor D. Lawley, Pippa G. Corrie

Sequential azacitidine and carboplatin induces immune activation in platinum-resistant high-grade serous ovarian cancer cell lines and primes for checkpoint inhibitor immunotherapy

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Michelle W. Wong-Brown, Andre van der Westhuizen, Nikola A. Bowden

Effect of prior antibiotic or chemotherapy treatment on immunotherapy response in non-small cell lung cancer

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Andrew F. Nyein, Shahla Bari, Stephanie Hogue, Yayi Zhao, Bradley Maller, Sybil Sha, Maria F. Gomez, Dana E. Rollison, Lary A. Robinson

Lympho-vascular invasion impacts the prognosis in breast-conserving surgery: a systematic review and meta-analysis

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Yi-Ming Zhong, Fei Tong, Jun Shen

Effect of tumour size ratio on liver recurrence-free survival of patients undergoing hepatic resection for colorectal liver metastases

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Yana Zhai, Weijun Bai, Jin Zhou, Qian Dong, Jingdong Zhang

The influence of docetaxel schedule on treatment tolerability and efficacy in patients with metastatic breast cancer: a systematic review and meta-analysis of randomized controlled trials

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Maarten van Eijk, Marit A. C. Vermunt, Erik van Werkhoven, Erica A. Wilthagen, Alwin D. R. Huitema, Jos H. Beijnen

The mixed blessing of AMPK signaling in Cancer treatments

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Mehrshad Sadria, Deokhwa Seo, Anita T. Layton

An observational study of workflows to support fecal testing for colorectal cancer screening in primary care practices serving Medicaid enrollees

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Cynthia M. Mojica, Rose Gunn, Robyn Pham, Edward J. Miech, Ann Romer, Stephanie Renfro, Khaya D. Clark, Melinda M. Davis

Identification of TIMELESS and RORA as key clock molecules of non-small cell lung cancer and the comprehensive analysis

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Haocheng Xian, Yuan Li, Boliang Zou, Yajuan Chen, Houqing Yin, Xuejun Li, Yan Pan

The role of SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration

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Jiahua Li, Hui Shi, Zhanyuan Yuan, Zhiheng Wu, Haohao Li, Yuelong Liu, Ming Lu, Ming Lu

The Patient Navigator: Can a systematically developed online health information tool improve patient participation and outcomes related to the consultation in older patients newly diagnosed with colorectal cancer?

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Melanie de Looper, Ellen M. A. Smets, Barbara C. Schouten, Sifra Bolle, Eric H. J. Belgers, Eric H. Eddes, Jeroen W. A. Leijtens, Julia C. M. van Weert

High complement protein C1q levels in pulmonary fibrosis and non-small cell lung cancer associated with poor prognosis

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Wenxin Kou, Bo Li, Yeifei Shi, Yifan Zhao, Qing Yu, Jianhui Zhuang, Yawei Xu, Wenhui Peng

Improving power in PSA response analyses of metastatic castration-resistant prostate cancer trials

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Michael J. Grayling, Martina McMenamin, Robert Chandler, Rakesh Heer, James M. S. Wason

Correction to: Mapping the EORTC QLQ-C30 to EQ-5D-3L in patients with breast cancer

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Laura A. Gray, Monica Hernandez Alava, Allan J. Wailoo

Predictive value of preoperative platelet-to-albumin ratio and apolipoprotein B-to-apolipoprotein A1 ratio for osteosarcoma in children and adolescents: a retrospective study of 118 cases

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Cong Ma, Ruizhen Li, Ronghui Yu, Jingjing Guo, Jianyun Xu, Xuhui Yuan, Jianfeng Guo

Online calculator to predict early mortality in patient with surgically treated recurrent lower-grade glioma

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Ruolun Wei, Chao Zhao, Jianguo Li, Fengdong Yang, Yake Xue, Xinting Wei

Identification of a ZC3H12D-regulated competing endogenous RNA network for prognosis of lung adenocarcinoma at single-cell level

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Wenhan Chen, Zhifeng Guo, Jingyang Wu, Guofu Lin, Shaohua Chen, Qinhui Lin, Jiansheng Yang, Yuan Xu, Yiming Zeng

The expression and survival significance of sodium glucose transporters in pancreatic cancer

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Jiali Du, Jichun Gu, Junyuan Deng, Lei Kong, Yujie Guo, Chen Jin, Yun Bao, Deliang Fu, Ji Li

CANT1 serves as a potential prognostic factor for lung adenocarcinoma and promotes cell proliferation and invasion in vitro

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Qiwei Yao, Yilin Yu, Zhiping Wang, Mengyan Zhang, Jiayu Ma, Yahua Wu, Qunhao Zheng, Jiancheng Li

Postoperative survival effect of the number of examined lymph nodes on esophageal squamous cell carcinoma with pathological stage T1–3N0M0

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Lei-Lei Wu, Jiu-Di Zhong, Jia-Li Zhu, Lu Kang, Yang-Yu Huang, Peng Lin, Hao Long, Lan-Jun Zhang, Qi-Long Ma, Li-Hong Qiu, Guo-Wei Ma

Impact of neoadjuvant intensity-modulated radiation therapy on borderline resectable pancreatic cancer with arterial abutment; a prospective, open-label, phase II study in a single institution

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Toshihiko Masui, Kazuyuki Nagai, Takayuki Anazawa, Asahi Sato, Yuichiro Uchida, Kenzo Nakano, Akitada Yogo, Akihiro Kaneda, Naoto Nakamura, Michio Yoshimura, Takashi Mizowaki, Norimitsu Uza, Akihisa Fukuda, Shigemi Matsumoto, Masashi Kanai, Hiroyoshi Isoda, Masaki Mizumoto, Satoru Seo, Koichiro Hata, Kojiro Taura, Yoshiya Kawaguchi, Kyoichi Takaori, Shinji Uemoto, Etsuro Hatano

Influence of early colorectal cancer component on the positive margins after endoscopic resection: a retrospective study

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Qing-Wei Zhang, Zi-Hao Dai, Xiao-Yi Wang, Yun-Jie Gao, Zhi-Zheng Ge, Xiao-Bo Li

Relationship between insurance status and interhospital transfers among cancer patients in the United States

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Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Sandeep Appunni, Subrina Sundil, Emir Veledar, Peter McGranaghan, Raees Tonse, Sergio Jose Torralbas Fitz, Michael D. Chuong, Yazmin Odia, Ritesh Kotecha, Minesh P. Mehta, Rupesh Kotecha

A risk scoring system to predict the individual incidence of early-onset colorectal cancer

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Jialin Gu, Yan Li, Jialin Yu, Miao Hu, Yi Ji, Lingchang Li, Canhong Hu, Guoli Wei, Jiege Huo

Depletion of C12orf48 inhibits gastric cancer growth and metastasis via up-regulating Poly r(C)-Binding Protein (PCBP) 1

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Lele Lin, Hongbo Li, Dike Shi, Zhiqiang Liu, Yunhai Wei, Wei Wang, Dan Wu, Baozhong Li, Qingqu Guo

RETRACTED ARTICLE: Repression of lncRNA PART1 attenuates ovarian cancer cell viability, migration and invasion through the miR-503-5p/FOXK1 axis

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Bing Li, Ge Lou, Jiahui Zhang, Ning Cao, Xi Yu

Ceftazidime and cefepime antagonize 5-fluorouracil’s effect in colon cancer cells

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Christina Pfab, Anush Abgaryan, Barbara Danzer, Fatme Mourtada, Weaam Ali, André Gessner, Nahed El-Najjar

Number of negative lymph nodes with a positive impact on survival of stage III colon cancer; a retrospective observation study for right side and left side colon

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Yi-Hung Kuo, Jeng-Fu You, Hsin-Yuan Hung, Chih-Chien Chin, Jy-Ming Chiang, Chia-Hao Chang

Decreased serum apolipoprotein A1 level predicts poor prognosis of patients with de novo myelodysplastic syndromes

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Cong Shi, Shengping Gong, An Wu, Shujun Yang, Duobing Zou, Yi Zhang, Ningning Wu, Chao Ma, Songqiu Shi, Ying Chen, Ying Wu, Xiaojiao Zheng, Zhenya Huang, Jianghua Ding, Guifang Ouyang, Qitian Mu

Baseline blood count levels increase odds of cytopenia among CML patients in Kenya: a case control study

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Angela McLigeyo, Jamilla Rajab, Peter Oyiro, Mohammed Ezzi, Yatich Bett, Matilda Ong’ondi, Andrew Odhiambo, Sitna Mwanzi, Nicholas Othieno-Abinya

Randomized double-blind clinical trial comparing safety and efficacy of the biosimilar BCD-021 with reference bevacizumab

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Daniil L. Stroyakovskiy, Natalya V. Fadeeva, Marina P. Matrosova, Konstantin G. Shelepen, Grigoriy A. Adamchuk, Bodhisatta Roy, Rajnish Nagarkar, Mahesh Kalloli, Daria Zhuravleva, Georgiy D. Voevodin, Mariya S. Shustova, Fedor Kryukov

Initial and ten-year treatment patterns among 11,000 breast cancer patients undergoing breast surgery—an analysis of German claims data

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Miriam Heinig, Franziska Heinze, Sarina Schwarz, Ulrike Haug

Pre-clinical and clinical studies on the role of RBM3 in muscle-invasive bladder cancer: longitudinal expression, transcriptome-level effects and modulation of chemosensitivity

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Sara Wahlin, Karolina Boman, Bruce Moran, Björn Nodin, William M. Gallagher, Emelie Karnevi, Karin Jirström

Acceptability and safety of thermal ablation to prevent cervical cancer in sub-Saharan Africa

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Tania Metaxas, Bruno Kenfack, Jessica Sormani, Eveline Tincho, Sophie Lemoupa Makajio, Ania Wisniak, Pierre Vassilakos, Patrick Petignat

Quantitative proteomic analysis of GnRH agonist treated GBM cell line LN229 revealed regulatory proteins inhibiting cancer cell proliferation

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Priyanka H. Tripathi, Javed Akhtar, Jyoti Arora, Ravindra Kumar Saran, Neetu Mishra, Ravindra Varma Polisetty, Ravi Sirdeshmukh, Poonam Gautam

Depressive and anxiety symptoms among Japanese cancer survivors: Japan cancer survivorship research project

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Motoki Endo, Kentaro Matsui, Rie Akaho, Kiyomi Mitsui, Yan Yan, Yuya Imai, Yuito Ueda, Go Muto, Gautam A. Deshpande, Yasuhisa Terao, Satoru Takeda, Mitsue Saito, Kazuhiko Hayashi, Katsuji Nishimura, Takeshi Tanigawa

Unmet needs of 1210 Chinese breast cancer survivors and associated factors: a multicentre cross-sectional study

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Xiaofan Bu, Cai Jin, Rongrong Fan, Andy S. K. Cheng, Peter H. F. Ng, Yimin Xia, Xiangyu Liu

Prognostic significance of lateral pelvic lymph node dissection for middle-low rectal cancer patients with lateral pelvic lymph node metastasis: a propensity score matching study

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Sicheng Zhou, Yujuan Jiang, Wei Pei, Jianwei Liang, Zhixiang Zhou

Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes

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Helena Olbertova, Karla Plevova, Sarka Pavlova, Jitka Malcikova, Jana Kotaskova, Kamila Stranska, Michaela Spunarova, Martin Trbusek, Veronika Navrkalova, Barbara Dvorackova, Nikola Tom, Karol Pal, Marie Jarosova, Yvona Brychtova, Anna Panovska, Michael Doubek, Sarka Pospisilova

Uncovering potential genes in colorectal cancer based on integrated and DNA methylation analysis in the gene expression omnibus database

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Guanglin Wang, Feifei Wang, Zesong Meng, Na Wang, Chaoxi Zhou, Juan Zhang, Lianmei Zhao, Guiying Wang, Baoen Shan

Somatic mutations in collagens are associated with a distinct tumor environment and overall survival in gastric cancer

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Alexander S. Brodsky, Jay Khurana, Kevin S. Guo, Elizabeth Y. Wu, Dongfang Yang, Ayesha S. Siddique, Ian Y. Wong, Ece D. Gamsiz Uzun, Murray B. Resnick

FCER1G positively relates to macrophage infiltration in clear cell renal cell carcinoma and contributes to unfavorable prognosis by regulating tumor immunity

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Keqin Dong, Wenjin Chen, Xiuwu Pan, Hongru Wang, Ye Sun, Cheng Qian, Weijie Chen, Chao Wang, Fu Yang, Xingang Cui

Facilitators and barriers to reducing chemotherapy for early-stage breast cancer: a qualitative analysis of interviews with patients and patient advocates

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Courtney Andrews, Timothy C. Childers, Kimberly D. Wiseman, Valerie Lawhon, Stacey Ingram, Mary Lou Smith, Antonio C. Wolff, Lynne Wagner, Gabrielle B. Rocque

Identification of a glycolysis-related gene signature for predicting prognosis in patients with hepatocellular carcinoma

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Junjie Kong, Guangsheng Yu, Wei Si, Guangbing Li, Jiawei Chai, Yong Liu, Jun Liu

Ovarian cancer G protein-coupled receptor 1 inhibits A549 cells migration through casein kinase 2α intronless gene and neutral endopeptidase

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Adhikarimayum Lakhikumar Sharma, Puyam Milan Meitei, Takhellambam Chanu Machathoibi, Naorem Tarundas Singh, Thiyam Ramsing Singh, Lisam Shanjukumar Singh

The ISCON-trial protocol: laparoscopic ischemic conditioning prior to esophagectomy in patients with esophageal cancer and arterial calcifications

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A. van der Veen, L. M. Schiffmann, E. M. de Groot, I. Bartella, P. A. de Jong, A. S. Borggreve, L. A. A. Brosens, D. Pinto Dos Santos, H. Fuchs, J. P. Ruurda, C. J. Bruns, R. van Hillegersberg, W. Schröder

Endogenous oestradiol and progesterone as predictors of oncogenic human papillomavirus (HPV) persistence

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Susanne Fischer, Ulrike Kuebler, Elvira Abbruzzese, Christian Breymann, Laura Mernone, Ulrike Ehlert

Polymorphisms in autophagy genes are genetic susceptibility factors in glioblastoma development

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E. Bueno-Martínez, M. Lara-Almunia, C. Rodríguez-Arias, A. Otero-Rodríguez, S. Garfias-Arjona, R. González-Sarmiento

Longitudinal minimal residual disease assessment in multiple myeloma patients in complete remission – results from the NMSG flow-MRD substudy within the EMN02/HO95 MM trial

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Alexander Schmitz, Rasmus Froberg Brøndum, Hans Erik Johnsen, Ulf-Henrik Mellqvist, Anders Waage, Peter Gimsing, Davine Hofste op Bruinink, Vincent van der Velden, Bronno van der Holt, Markus Hansson, Niels Frost Andersen, Ulf Christian Frølund, Carsten Helleberg, Fredrik H. Schjesvold, Lucia Ahlberg, Nina Gulbrandsen, Bjorn Andreasson, Birgitta Lauri, Einar Haukas, Julie Støve Bødker, Anne Stidsholt Roug, Martin Bøgsted, Marianne T. Severinsen, Henrik Gregersen, Niels Abildgaard, Pieter Sonneveld, Karen Dybkær

Real world risk of infusion reactions and effectiveness of front-line obinutuzumab plus chlorambucil compared with other frontline treatments for chronic lymphocytic leukemia

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Nicole Bourrier, Ivan Landego, Oliver Bucher, Mandy Squires, Erin Streu, Irena Hibbert, Theresa Whiteside, Spencer B. Gibson, Marc Geirnaert, James B. Johnston, David E. Dawe, Versha Banerji

Secular trends in incidence and mortality of cervical cancer in India and its states, 1990-2019: data from the Global Burden of Disease 2019 Study

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Mayank Singh, Ravi Prakash Jha, Neha Shri, Krittika Bhattacharyya, Priyanka Patel, Deepak Dhamnetiya

Angiotensin blockade therapy and survival in pancreatic cancer: a population study

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Scott W. Keith, Vittorio Maio, Hwyda A. Arafat, Matthew Alcusky, Thomas Karagiannis, Carol Rabinowitz, Harish Lavu, Daniel Z. Louis

Step-by-step and orderly lowering of the height of inferior vena cava tumor thrombus is the key to robot-assisted thrombectomy for Mayo III/IV tumor thrombus

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Guo-Dong Zhao, Xiu-Ping Zhang, Ming-Gen Hu, Qing-Bao Huang, Shuai Xu, Bao-Jun Wang, Xin Ma, Xu Zhang, Wen-Bo Zou, Xuan Zhang, Zhi-Ming Zhao, Xiang-Long Tan, Sai Chou, Gang Wang, Rong Liu

Clinical characteristics, pregnancy outcomes and ovarian function of pregnancy-associated breast cancer patients: a retrospective age-matched study

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Qiuyue Liao, Dongmei Deng, Qin Xie, Xiaoqin Gong, Xiaolin Meng, Yun Xia, Jihui Ai, Kezhen Li

The short-term and oncologic outcomes of younger VS older colorectal cancer patients undergoing primary surgery: a propensity score matching analysis

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Xiao-Yu Liu, Bing Kang, Yu-Xi Cheng, Chao Yuan, Wei Tao, Bin Zhang, Zheng-Qiang Wei, Dong Peng

Massive digital gene expression analysis reveals different predictive profiles for immune checkpoint inhibitor therapy between adenocarcinoma and squamous cell carcinoma of advanced lung cancer

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Toshihiko Kaneda, Takayasu Kurata, Tomoko Yoshida, Kayoko Kibata, Hiroshige Yoshioka, Hiroaki Yanagimoto, Kazuhiko Takeda, Takao Yoshida, Koji Tsuta

Positive H. pylori status predicts better prognosis of non-cardiac gastric cancer patients: results from cohort study and meta-analysis

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Zhifang Jia, Min Zheng, Jing Jiang, Donghui Cao, Yanhua Wu, Yuzheng Zhang, Yingli Fu, Xueyuan Cao

Lipid-lowering drug adherence and combination therapy effects on gastrointestinal cancer in patients with dyslipidemia without diabetes: a retrospective cohort study in South Korea

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Kyu-Tae Han, Seungju Kim

Low-grade inflammation in survivors of childhood cancer and testicular cancer and its association with hypogonadism and metabolic risk factors

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Henrik Ekedahl, Sigrid Isaksson, Olof Ståhl, Karolina Bogefors, Patrik Romerius, Jakob Eberhard, Aleksander Giwercman

Colorectal cancer community engagement: a qualitative exploration of American Indian voices from North Dakota

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Nicole Redvers, Mia Wilkinson, Courtney Fischer

Perception of information to Swedish melanoma patients in routine clinical practice – a cross-sectional survey

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Helena Tufvesson Stiller, Rasmus Mikiver, Srinivas Uppugunduri, Marcus Schmitt-Egenolf

Genome-wide association study of serum tumor markers in Southern Chinese Han population

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Xiukuan Li, Fenghua Bai, Xingwei Wei, Tianbo Jin, Chen Li, Yutian Zhang, Mei Lin, Xiaoli Zhou, Yufei Xie, Chanyi He, Qi Lin, Ping He, Shuyuan Chu, Yipeng Ding

Knowledge, use and attitudes of healthcare professionals towards patient-reported outcome measures (PROMs) at a comprehensive cancer center

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Cinzia Brunelli, Emanuela Zito, Sara Alfieri, Claudia Borreani, Anna Roli, Augusto Caraceni, Giovanni Apolone

Improved automated early detection of breast cancer based on high resolution 3D micro-CT microcalcification images

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Redona Brahimetaj, Inneke Willekens, Annelien Massart, Ramses Forsyth, Jan Cornelis, Johan De Mey, Bart Jansen

Diagnostic performance of MRI, SPECT, and PET in detecting renal cell carcinoma: a systematic review and meta-analysis

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Qihua Yin, Huiting Xu, Yanqi Zhong, Jianming Ni, Shudong Hu

Transcriptome analysis of cervical cancer exosomes and detection of HPVE6*I transcripts in exosomal RNA

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Anjali Bhat, Joni Yadav, Kulbhushan Thakur, Nikita Aggarwal, Arun Chhokar, Tanya Tripathi, Tejveer Singh, Mohit Jadli, Veeramohan Veerapandian, Alok Chandra Bharti

The prognostic and predictive value of ESR1 fusion gene transcripts in primary breast cancer

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Silvia R. Vitale, Kirsten Ruigrok-Ritstier, A. Mieke Timmermans, Renée Foekens, Anita M. A. C. Trapman-Jansen, Corine M. Beaufort, Paolo Vigneri, Stefan Sleijfer, John W. M. Martens, Anieta M. Sieuwerts, Maurice P. H. M. Jansen

SYT-SSX1 enhances the invasiveness and maintains stem-like cell properties in synovial sarcoma via induction of TGF-β1/Smad signaling

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Yan Qi, Shuang-Shuang Dong, Yong-Lai He, Zi-Han Liu, Ya-Lan Huang, Ning Wang, Zhen Zhang, Zhong Li, Mei Er Tu He Ta Mi Shi, Xiao Feng, Qing Yao, Hong Zou, Jian-Ming Hu, Li-Juan Pang, Feng Li

Relationship between serum lipid levels and the immune microenvironment in breast cancer patients: a retrospective study

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Wataru Goto, Shinichiro Kashiwagi, Yuri Kamei, Chika Watanabe, Naoki Aomatsu, Katsumi Ikeda, Yoshinari Ogawa, Kosei Hirakawa, Masaichi Ohira

Nectin-4 and DNA mismatch repair proteins expression in upper urinary tract urothelial carcinoma (UTUC) as a model for tumor targeting approaches: an ImGO pilot study

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Maria Letizia Calandrella, Simona Francesconi, Cecilia Caprera, Claudia Mosillo, Claudia Caserta, Diana Giannarelli, Matteo Corsi, Serena Macrini, Annalisa Guida, Stefano Ascani, Sergio Bracarda

Rituximab in combination with gemcitabine plus cisplatin in patients with recurrent and metastatic head and neck squamous cell carcinoma: a phase I trial

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Ching-Yun Hsieh, Ming-Yu Lien, Chen-Yuan Lin, Wen-Jyi Lo, Chung-Hung Hua, Wei-Chao Chang, Chang-Fang Chiu, Ching-Chan Lin

Prospective observational study of the efficacy of oral uracil and tegafur plus leucovorin for stage II colon cancer with risk factors for recurrence using propensity score matching (JFMC46-1201)

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Sotaro Sadahiro, Kazuhiro Sakamoto, Takashi Tsuchiya, Takao Takahashi, Hiroki Ohge, Toshihiko Sato, Ken Kondo, Yutaka Ogata, Hideo Baba, Michio Itabashi, Masataka Ikeda, Madoka Hamada, Kiyoshi Maeda, Hiroyuki Masuko, Keiichi Takahashi, Junichi Sakamoto, Mitsuo Kusano, Ichinosuke Hyodo, Masataka Taguri, Satoshi Morita

Serotoninergic receptor ligands improve Tamoxifen effectiveness on breast cancer cells

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Maria Rosaria Ambrosio, Elisa Magli, Giuseppe Caliendo, Rosa Sparaco, Paola Massarelli, Vittoria D’Esposito, Teresa Migliaccio, Giusy Mosca, Ferdinando Fiorino, Pietro Formisano

Lifestyle predictors for inconsistent participation to fecal based colorectal cancer screening

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Markus Dines Knudsen, Ane Sørlie Kvaerner, Edoardo Botteri, Øyvind Holme, Anette Hjartåker, Mingyang Song, Espen Thiis-Evensen, Kristin Ranheim Randel, Geir Hoff, Paula Berstad

Establishment of an orthotopic prostate cancer xenograft mouse model using microscope-guided orthotopic injection of LNCaP cells into the dorsal lobe of the mouse prostate

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Weiyong Liu, Yunkai Zhu, Lei Ye, Yajuan Zhu, Yuhao Wang

Feasibility of administering human pancreatic cancer chemotherapy in a spontaneous pancreatic cancer mouse model

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Abagail M. Delahoussaye, Joseph Abi Jaoude, Morgan Green, Tara N. Fujimoto, Jessica Molkentine, Carolina J. Garcia Garcia, Jason P. Gay, Ningping Feng, Joseph Marszalek, Natalie Fowlkes, Cullen M. Taniguchi

Stereotactic body radiation therapy as a salvage treatment for single viable hepatocellular carcinoma at the site of incomplete transarterial chemoembolization: a retrospective analysis of 302 patients

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Sumin Lee, Jinhong Jung, Jin-hong Park, So Yeon Kim, Jonggi Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Hee Hyun Park, Jong Hoon Kim, Sang Min Yoon

Potential efficacy of weekly low-dose administration of bevacizumab as a combination therapy for platinum-resistant ovarian carcinoma: a retrospective analysis

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Jin Suminokura, Morikazu Miyamoto, Tomoyuki Yoshikawa, Hiroko Kouta, Yoshihiro Kikuchi, Taira Hada, Hiroki Ishibashi, Tsubasa Ito, Hideki Iwahashi, Soichiro Kakimoto, Rie Suzuki, Hiroko Matsuura, Naohisa Kishimoto, Masashi Takano

Efficacy and safety of Androgen Deprivation Therapy (ADT) combined with modified docetaxel chemotherapy versus ADT combined with standard docetaxel chemotherapy in patients with metastatic castration-resistant prostate cancer: study protocol for a multicentre prospective randomized controlled trial

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Xiangwei Yang, Hong Chen, Duanya Xu, Xianju Chen, Yamei Li, Jun Tian, Dongwen Wang, Jun Pang

Dosimetric analysis of radiation-induced brainstem necrosis for nasopharyngeal carcinoma treated with IMRT

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Xigang Fan, Yecai Huang, Peng Xu, Yanmei Min, Jie Li, Mei Feng, Guohui Xu, Jinyi Lang

Sarcopenia as a novel prognostic factor in the patients of primary localized gastrointestinal stromal tumor

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He Song, Xianhao Xiao, Gang Liu, Jianping Zhou

Loss of REST in breast cancer promotes tumor progression through estrogen sensitization, MMP24 and CEMIP overexpression

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Ashley S. Cloud, Aditya M. Vargheese, Sumedha Gunewardena, Raeann M. Shimak, Sornakala Ganeshkumar, Easwari Kumaraswamy, Roy A. Jensen, Vargheese M. Chennathukuzhi

Prognostic significance of KLF4 in solid tumours: an updated meta-analysis

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Xiaoya Luo, Yue Zhang, Ying Meng, Ming Ji, Yongjun Wang

Correction to: Attention to principles of exercise training: an updated systematic review of randomized controlled trials in cancers other than breast and prostate

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Kelcey A. Bland, Sarah E. Neil-Sztramko, Kendra Zadravec, Mary E. Medysky, Jeffrey Kong, Kerri M. Winters-Stone, Kristin L. Campbell

Flemish population-based cancer screening programs: impact of COVID-19 related shutdown on short-term key performance indicators

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• COVID-19
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Svetlana Jidkova, Sarah Hoeck, Eliane Kellen, Saskia le Cessie, Mathijs C. Goossens

Functional interaction between S100A1 and MDM2 may modulate p53 signaling in normal and malignant endometrial cells

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Mayu Nakagawa, Shyoma Higuchi, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Ako Yokoi, Yu Ishibashi, Takashi Ito, Makoto Saegusa

The survival strength of younger patients in BCLC stage 0-B of hepatocellular carcinoma: basing on competing risk model

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Huiwen Yan, Xinhui Wang, Xiaoli Liu, Peng Wang, Lihua Yu, Dongdong Zhou, Zhiyun Yang

The genetic landscape of pancreatic head ductal adenocarcinoma in China and prognosis stratification

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Yefan Yang, Ying Ding, Yuxi Gong, Sha Zhao, Mingna Li, Xiao Li, Guoxin Song, Boya Zhai, Jin Liu, Yang Shao, Liuqing Zhu, Jiaohui Pang, Yutong Ma, Qiuxiang Ou, Xue Wu, Zhihong Zhang

Integrated analysis of the prognostic and oncogenic roles of OPN3 in human cancers

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Wei Zhang, Jianglong Feng, Wen Zeng, Zhi He, Wenxiu Yang, Hongguang Lu

An integrated analysis of the competing endogenous RNA network associated of prognosis of stage I lung adenocarcinoma

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Yuan Xu, Guofu Lin, Yifei Liu, Xianbin Lin, Hai Lin, Zhifeng Guo, Yingxuan Xu, Qinhui Lin, Shaohua Chen, Jiansheng Yang, Yiming Zeng

No axillary surgical treatment for lymph node-negative patients after ultra-sonography [NAUTILUS]: protocol of a prospective randomized clinical trial

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• Study protocol

Ji Gwang Jung, Se Hyun Ahn, Seeyoun Lee, Eun-Kyu Kim, Jai Min Ryu, Seho Park, Woosung Lim, Yong Sik Jung, Il Yong Chung, Joon Jeong, Ji Hyun Chang, Kyung Hwan Shin, Jung Min Chang, Woo Kyung Moon, Wonshik Han

The PI3K/AKT/mTOR signaling pathway is aberrantly activated in primary central nervous system lymphoma and correlated with a poor prognosis

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Xiaowei Zhang, Yuchen Wu, Xuefei Sun, Qu Cui, Xueyan Bai, Gehong Dong, Zifen Gao, Yaming Wang, Chunji Gao, Shengjun Sun, Nan Ji, Yuanbo Liu

Dynamic contrast-enhanced MRI in malignant pleural mesothelioma: prediction of outcome based on DCE-MRI measurements in patients undergoing cytotoxic chemotherapy

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Martina Vivoda Tomšič, Peter Korošec, Viljem Kovač, Sotirios Bisdas, Katarina Šurlan Popovič

Developing a 5-gene prognostic signature for cervical cancer by integrating mRNA and copy number variations

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Wenxin Liu, Qiuying Jiang, Chao Sun, ShiHao Liu, Zhikun Zhao, Dongfang Wu

Four differentially expressed genes can predict prognosis and microenvironment immune infiltration in lung cancer: a study based on data from the GEO

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Shaodi Wen, Weiwei Peng, Yuzhong Chen, Xiaoyue Du, Jingwei Xia, Bo Shen, Guoren Zhou

Correction to: Capsular extension at ultrasound is associated with lateral lymph node metastasis in patients with papillary thyroid carcinoma: a retrospective study

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Lei Ye, Lei Hu, Weiyong Liu, Yuanyuan Luo, Zhe Li, Zuopeng Ding, Chunmei Hu, Lin Wang, Yajuan Zhu, Le Liu, Xiaopeng Ma, Yuan Kong, Liangliang Huang

Holmium laser-assisted laparoscopic partial cystectomy for bladder cancer: a single-institutional pilot study with technical feasibility and short-term oncological outcome

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Kang Sup Kim, Sang Hoon Kim, Hyuk Jin Cho, Hong Jin Sur, Yong Sun Choi

Long non-coding RNA AC087388.1 as a novel biomarker in colorectal cancer

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Arash Poursheikhani, Mohammad Reza Abbaszadegan, Mohammad Amin Kerachian

A Comprehensive Prognostic Analysis of POLD1 in Hepatocellular Carcinoma

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Hui Tang, Tingting You, Zhao Sun, Chunmei Bai

Clinical outcomes of advanced non-small cell lung cancer patients harboring distinct subtypes of EGFR mutations and receiving first-line tyrosine kinase inhibitors: brain metastasis and de novo T790M matters

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Ya Zeng, Tiantian Guo, Yue Zhou, Yang Zhao, Li Chu, Xiao Chu, Xi Yang, Jianjiao Ni, Zhengfei Zhu

Effectiveness of educational intervention on breast cancer knowledge and breast self-examination among female university students in Bangladesh: a pre-post quasi-experimental study

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Rumpa Sarker, Md. Saiful Islam, Mst. Sabrina Moonajilin, Mahmudur Rahman, Hailay Abrha Gesesew, Paul R. Ward

Correction: Establishment of an orthotopic prostate cancer xenograft mouse model using microscope-guided orthotopic injection of LNCaP cells into the dorsal lobe of the mouse prostate

• Open Access
• Correction

Weiyong Liu, Yunkai Zhu, Lei Ye, Yajuan Zhu, Yuhao Wang

Deep learning identifies Acute Promyelocytic Leukemia in bone marrow smears

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Jan-Niklas Eckardt, Tim Schmittmann, Sebastian Riechert, Michael Kramer, Anas Shekh Sulaiman, Katja Sockel, Frank Kroschinsky, Johannes Schetelig, Lisa Wagenführ, Ulrich Schuler, Uwe Platzbecker, Christian Thiede, Friedrich Stölzel, Christoph Röllig, Martin Bornhäuser, Karsten Wendt, Jan Moritz Middeke

Chemotherapy versus chemoradiotherapy for FIGO stages IB1 and IIA1 cervical squamous cancer patients with lymphovascular space invasion: a retrospective study

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Hao Zhang, Rao Yu, Lan Zhang, Rong Wang, Lin Xiao

Breast cancer screening in sub-Saharan Africa: a systematic review and ethical appraisal

• Open Access
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Yehoda M. Martei, Bege Dauda, Verna Vanderpuye

A 10-year retrospective study of lung cancer in Uganda

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Naghib Bogere, Felix Bongomin, Andrew Katende, Blair Andrew Omaido, Elizabeth Namukwaya, Harriet Mayanja-Kizza, Victoria Walusansa

Safety and efficacy of MIKE-1 in patients with advanced pancreatic cancer: a study protocol for an open-label phase I/II investigator-initiated clinical trial based on a drug repositioning approach that reprograms the tumour stroma

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• Study protocol

Yasuyuki Mizutani, Tadashi Iida, Eizaburo Ohno, Takuya Ishikawa, Fumie Kinoshita, Yachiyo Kuwatsuka, Miwa Imai, Shinobu Shimizu, Toshihisa Tsuruta, Atsushi Enomoto, Hiroki Kawashima, Mitsuhiro Fujishiro

Primary versus postoperative gamma knife radiosurgery for intracranial benign meningiomas: a matched cohort retrospective study

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Junyi Fu, Jiamin Zeng, Minyi Huang, Shunyao Liang, Yong He, Longchang Xie, Yinhui Deng, Jinxiu Yu

Risk factors of esophageal fistula induced by re-radiotherapy for recurrent esophageal cancer with local primary site

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Xinran Wang, Bing Hu, Jinhu Chen, Feihong Xie, Dan Han, Qian Zhao, Hongfu Sun, Chengrui Fu, Chengxin Liu, Zhongtang Wang, Haiqun Lin, Wei Huang

Prevalence of specific and recurrent/founder pathogenic variants in BRCA genes in breast and ovarian cancer in North Africa

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Oubaida ElBiad, Abdelilah Laraqui, Fatima El Boukhrissi, Chaimaa Mounjid, Maryame Lamsisi, Tahar Bajjou, Hicham Elannaz, Amine Idriss Lahlou, Jaouad Kouach, Khadija Benchekroune, Mohammed Oukabli, Hafsa Chahdi, Moulay Mustapha Ennaji, Rachid Tanz, Yassir Sbitti, Mohammed Ichou, Khalid Ennibi, Bouabid Badaoui, Yassine Sekhsokh

The Kaiser Permanente Research Bank Cancer Cohort: a collaborative resource to improve cancer care and survivorship

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Heather Spencer Feigelson, Christina L. Clarke, Stephen K. Van Den Eeden, Sheila Weinmann, Andrea N. Burnett-Hartman, Sarah Rowell, Shauna Goldberg Scott, Larissa L. White, Monica Ter-Minassian, Stacey A. A. Honda, Deborah R. Young, Aruna Kamineni, Terrence Chinn, Alexander Lituev, Alan Bauck, Elizabeth A. McGlynn

Deep-learning model for predicting the survival of rectal adenocarcinoma patients based on a surveillance, epidemiology, and end results analysis

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Haohui Yu, Tao Huang, Bin Feng, Jun Lyu

Co-deficiency of B7-H3 and B7-H4 identifies high CD8 + T cell infiltration and better prognosis in pancreatic cancer

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Shuping Si, Lei Wang, Hui Cao, Yuhua Xu, Qiang Zhan

Preoperative versus postoperative chemo-radiotherapy for locally advanced gastric cancer: a multicenter propensity score-matched analysis

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Ning Li, Xiaoyong Xiang, Dongbin Zhao, Xin Wang, Yuan Tang, Yihebali Chi, Lin Yang, Liming Jiang, Jun Jiang, Jinming Shi, Wenyang Liu, Hui Fang, Yu Tang, Bo Chen, Ningning Lu, Hao Jing, Shunan Qi, Shulian Wang, Yueping Liu, Yongwen Song, Yexiong Li, Liyuan Zhang, Jing Jin

Norepinephrine promotes glioma cell migration through up-regulating the expression of Twist1

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Xue Wang, Ying Wang, Fang Xie, Zi-Tian Song, Zi-Qian Zhang, Yun Zhao, Shi-Da Wang, Hui Hu, Yan-Shu Zhang, Ling-Jia Qian

Urinary metabolomics for discovering metabolic biomarkers of bladder cancer by UPLC-MS

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Rui Wang, Huaixing Kang, Xu Zhang, Qing Nie, Hongling Wang, Chaojun Wang, Shujun Zhou

Abundant expression of ferroptosis-related SAT1 is related to unfavorable outcome and immune cell infiltration in low-grade glioma

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Yanhua Mou, Lu Zhang, Zhantao Liu, Xiujun Song

The efficacy and safety of Iodine-131-metaiodobenzylguanidine therapy in patients with neuroblastoma: a meta-analysis

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Huihui He, Qiaoling Xu, Chunjing Yu

Cognitive behavioral therapy for reducing fear of cancer recurrence (FCR) among breast cancer survivors: a systematic review of the literature

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So-Young Park, Jung-Won Lim

Feasibility of a fast-track randomized controlled trial of cell-free and concentrated ascites reinfusion therapy for patients with refractory malignant ascites

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Naosuke Yokomichi, Kengo Imai, Masaki Sakamoto, Masashi Horiki, Toshihiro Yamauchi, Satoru Miwa, Satoshi Inoue, Yu Uneno, Hidekazu Suzuki, Toru Wada, Yuri Ichikawa, Tatsuya Morita

Association of annexin A10 expression with poor prognosis of intrahepatic cholangiocarcinoma

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Yu-Yun Shao, Hung-Yang Kuo, Yung-Ming Jeng, Yao-Ming Wu, Hsiu-Po Wang, Chiun Hsu, Chih-Hung Hsu, Hey-Chi Hsu, Ann-Lii Cheng, Zhong-Zhe Lin

Compliance with recommended cancer patient pathway timeframes and choice of treatment differed by cancer type and place of residence among cancer patients in Norway in 2015–2016

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Yngvar Nilssen, Odd Terje Brustugun, Morten Tandberg Eriksen, Marianne G. Guren, Erik Skaaheim Haug, Bjørn Naume, Ellen Schlichting, Bjørn Møller

Prognostic utility of systemic inflammatory markers and chronic hepatitis C virus infection status in hepatocellular carcinoma patients treated with local ablation

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Mohamed Abdulwahab Mohamed Ali, William Scott Harmsen, Khairy Hammam Morsy, Ghada Moustapha Kamal Galal, Terry M. Therneau, Lewis Rowland Roberts

A longitudinal cohort study of watch and wait in complete clinical responders after chemo-radiotherapy for localised rectal cancer: study protocol

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• Study protocol

Sina Vatandoust, David Wattchow, Luigi Sposato, Michael Z Michael, John Leung, Kirsten Gormly, Gang Chen, Erin L. Symonds, Jeanne Tie, Lito Electra Papanicolas, Susan Woods, Val Gebski, Kelly Mead, Aleksandra Kuruni, Christos S. Karapetis

Patient-reported outcomes associated with cancer screening: a systematic review

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Ashley Kim, Karen C. Chung, Christopher Keir, Donald L. Patrick

Long-term outcomes following 90Y Radioembolization of neuroendocrine liver metastases: evaluation of the radiation-emitting SIR-spheres in non-resectable liver tumor (RESiN) registry

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Thomas Y. Wong, Kevin S. Zhang, Ripal T. Gandhi, Zachary S. Collins, Ryan O’Hara, Eric A. Wang, Kirubahara Vaheesan, Lea Matsuoka, Daniel Y. Sze, Andrew S. Kennedy, Daniel B. Brown

Comprehensive analysis of the autophagy-dependent ferroptosis-related gene FANCD2 in lung adenocarcinoma

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Huikai Miao, Qiannan Ren, Hongmu Li, Mingyue Zeng, Dongni Chen, Chunmei Xu, Youfang Chen, Zhesheng Wen

ZNF703 promotes triple-negative breast cancer cells through cell-cycle signaling and associated with poor prognosis

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Xi Zhang, Xin Mu, Ou Huang, Zhitang Wang, Jialin Chen, Debo Chen, Gen Wang

Incidence and survival in oral and pharyngeal cancers in Finland and Sweden through half century

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Anni I. Koskinen, Otto Hemminki, Asta Försti, Kari Hemminki

Exposure–response analyses of cabozantinib in patients with metastatic renal cell cancer

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Stefanie D. Krens, Nielka P. van Erp, Stefanie L. Groenland, Dirk Jan A. R. Moes, Sasja F. Mulder, Ingrid M. E. Desar, Tom van der Hulle, Neeltje Steeghs, Carla M. L. van Herpen

Combination of ferroptosis and pyroptosis to construct a prognostic classifier and predict immune landscape, chemotherapeutic efficacy and immunosuppressive molecules in hepatocellular carcinoma

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Lijun Xu, Qing Zheng, Wenwen Liu

Natural killer cell-related gene signature predicts malignancy of glioma and the survival of patients

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Chenglong Li, Fangkun Liu, Lunquan Sun, Zhixiong Liu, Yu Zeng

Prognostic mutational subtyping in de novo diffuse large B-cell lymphoma

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Eugene Kim, Yanwen Jiang, Tao Xu, Alexandra Bazeos, Andrea Knapp, Christopher R. Bolen, Kathryn Humphrey, Tina G. Nielsen, Elicia Penuel, Joseph N. Paulson

Body size in early life and the risk of postmenopausal breast cancer

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TienYu Owen Yang, Benjamin J. Cairns, Kirstin Pirie, Jane Green, Valerie Beral, Sarah Floud, Gillian K. Reeves

Prognostic value and immune relevancy of a combined autophagy-, apoptosis- and necrosis-related gene signature in glioblastoma

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Ying Bi, Zeng-Hong Wu, Fei Cao

Prognostic significance of the skeletal muscle index and systemic inflammatory index in patients with lymph node-positive breast cancer after radical mastectomy

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Ru Tang, Jia-Peng Deng, Lei Zhang, Wen-Wen Zhang, Jia-Yuan Sun, Feng Chi, Jun Zhang, San-Gang Wu, Zhen-Yu He

Young people’s perspectives of thyroid cancer screening and its harms after the nuclear accident in Fukushima Prefecture: a questionnaire survey indicating opt-out screening strategy of the thyroid examination as an ethical issue

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Sanae Midorikawa, Akira Ohtsuru

Primary central nervous system lymphoma high incidence and poor survival in Finnish population-based analysis

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Inka Puhakka, Hanne Kuitunen, Pekka Jäkälä, Eila Sonkajärvi, Taina Turpeenniemi-Hujanen, Aino Rönkä, Tuomas Selander, Miika Korhonen, Outi Kuittinen

Improved urine DNA methylation panel for early bladder cancer detection

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Qixun Fang, Xu Zhang, Qing Nie, Jianqiang Hu, Shujun Zhou, Chaojun Wang

Circular RNA hsa_circ_0000277 promotes tumor progression and DDP resistance in esophageal squamous cell carcinoma

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Jiwei Cheng, Ruixiang Zhang, Ming Yan, Yin Li

Predicting biochemical-recurrence-free survival using a three-metabolic-gene risk score model in prostate cancer patients

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Yiqiao Zhao, Zijia Tao, Lei Li, Jianyi Zheng, Xiaonan Chen

Tenascin-C promotes bladder cancer progression and its action depends on syndecan-4 and involves NF-κB signaling activation

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Zhenfeng Guan, Yi Sun, Liang Mu, Yazhuo Jiang, Jinhai Fan

The impact of anti-tumor approaches on the outcomes of cancer patients with COVID-19: a meta-analysis based on 52 cohorts incorporating 9231 participants

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• COVID-19
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Qing Wu, Shuimei Luo, Xianhe Xie

Comparison of tumors with HER2 overexpression versus HER2 amplification in HER2-positive breast cancer patients

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Yoshiya Horimoto, Yumiko Ishizuka, Yuko Ueki, Toru Higuchi, Atsushi Arakawa, Mitsue Saito

Different inflammatory blood markers correlate with specific outcomes in incident HPV-negative head and neck squamous cell carcinoma: a retrospective cohort study

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Paolo Boscolo-Rizzo, Andrea D’Alessandro, Jerry Polesel, Daniele Borsetto, Margherita Tofanelli, Alberto Deganello, Michele Tomasoni, Piero Nicolai, Paolo Bossi, Giacomo Spinato, Anna Menegaldo, Andrea Ciorba, Stefano Pelucchi, Chiara Bianchini, Diego Cazzador, Giulia Ramaciotti, Valentina Lupato, Vittorio Giacomarra, Gabriele Molteni, Daniele Marchioni, Cristoforo Fabbris, Antonio Occhini, Giulia Bertino, Jonathan Fussey, Giancarlo Tirelli

Long-term cognitive, psychosocial, and neurovascular complications of unilateral head and neck irradiation in young to middle-aged adults

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Judith T. Pruijssen, Ashwin Wenmakers, Roy P. C. Kessels, Vitoria Piai, Frederick J. A. Meijer, Sjoert A. H. Pegge, Jacqueline J. Loonen, Anil M. Tuladhar, Hendrik H. G. Hansen, Johannes H. A. M. Kaanders, Joyce Wilbers

Mammary tumors alter the fecal bacteriome and permit enteric bacterial translocation

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Brett R. Loman, Kathryn L. G. Russart, Corena V. Grant, Alexis J. Lynch, Michael T. Bailey, Leah M. Pyter

High Intensity Aerobic exercise training and Immune cell Mobilization in patients with lung cancer (HI AIM)—a randomized controlled trial

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• Study protocol

Gitte Holmen Olofsson, Marta Kramer Mikkelsen, Anne-Mette Ragle, Anne Birgitte Christiansen, Anne Pries Olsen, Lise Heide-Ottosen, Cecilia Bech Horsted, Cia Moon Scharbau Pedersen, Lotte Engell-Noerregaard, Torben Lorentzen, Gitte Fredberg Persson, Anders Vinther, Dorte Lisbet Nielsen, Per thor Straten

Anti-tumor treatment and healthcare consumption near death in the era of novel treatment options for patients with melanoma brain metastases

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Annemarie C. Eggen, Geke A. P. Hospers, Ingeborg Bosma, Miranda C. A. Kramer, Anna K. L. Reyners, Mathilde Jalving

Comparison of comfort and complications of Implantable Venous Access Port (IVAP) with ultrasound guided Internal Jugular Vein (IJV) and Axillary Vein/Subclavian Vein (AxV/SCV) puncture in breast cancer patients: a randomized controlled study

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Yan Bo Chen, Hao Shi Bao, Ting Ting Hu, Zhou He, Biaolin Wen, Feng Tao Liu, Feng Xi Su, He Ran Deng, Jian Nan Wu

Development of nomogram models of inflammatory markers based on clinical database to predict prognosis for hepatocellular carcinoma after surgical resection

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Shuqi Mao, Xi Yu, Jihan Sun, Yong Yang, Yuying Shan, Jiannan Sun, Joseph Mugaanyi, Rui Fan, Shengdong Wu, Caide Lu

Thrombospondin-2 holds prognostic value and is associated with metastasis and the mismatch repair process in gastric cancer

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Xiao-dong Chu, Zheng-bin Lin, Ting Huang, Hui Ding, Yi-ran Zhang, Zhan Zhao, Shu-chen Huangfu, Sheng-hui Qiu, Yan-guan Guo, Xiao-li Chu, Jing-hua Pan, Yun-long Pan

PSMA PET/CT guided intensification of therapy in patients at risk of advanced prostate cancer (PATRON): a pragmatic phase III randomized controlled trial

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• Study protocol

Cynthia Ménard, Sympascho Young, Katherine Zukotynski, Robert J. Hamilton, François Bénard, Steven Yip, Christopher McCabe, Fred Saad, Michael Brundage, Roy Nitulescu, Glenn Bauman

Clinicians’ perceptions of barriers to cervical cancer screening for women living with behavioral health conditions: a focus group study

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Rahma S. Mkuu, Stephanie A. Staras, Sarah M. Szurek, Dalila D’Ingeo, Mary A. Gerend, Dianne L. Goede, Elizabeth A. Shenkman

Biweekly oxaliplatin plus S1 for Chinese elderly patients with advanced gastric or gastroesophageal junction cancer as the first-line therapy: a single-arm, phase 2 study

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Zhichao Jiang, Aiping Zhou, Yongkun Sun, Wen Zhang

Combining gene expression analysis of gastric cancer cell lines and tumor specimens to identify biomarkers for anti-HER therapies—the role of HAS2, SHB and HBEGF

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Karolin Ebert, Ivonne Haffner, Gwen Zwingenberger, Simone Keller, Elba Raimúndez, Robert Geffers, Ralph Wirtz, Elena Barbaria, Vanessa Hollerieth, Rouven Arnold, Axel Walch, Jan Hasenauer, Dieter Maier, Florian Lordick, Birgit Luber

Trends in treatment patterns and survival outcomes in advanced non-small cell lung cancer: a Canadian population-based real-world analysis

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Robert Carroll, Margherita Bortolini, Alan Calleja, Robin Munro, Shiying Kong, Melinda J. Daumont, John R. Penrod, Khalid Lakhdari, Laure Lacoin, Winson Y. Cheung

An integrative gene expression signature analysis identifies CMS4 KRAS-mutated colorectal cancers sensitive to combined MEK and SRC targeted therapy

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Mingli Yang, Thomas B. Davis, Lance Pflieger, Michael V. Nebozhyn, Andrey Loboda, Heiman Wang, Michael J. Schell, Ramya Thota, W. Jack Pledger, Timothy J. Yeatman

Nomograms to predict the prognosis in malignant ovarian germ cell tumors: a large cohort study

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Zixuan Song, Yizi Wang, Yangzi Zhou, Dandan Zhang

Development and validation of a gradient boosting machine to predict prognosis after liver resection for intrahepatic cholangiocarcinoma

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Gu-Wei Ji, Chen-Yu Jiao, Zheng-Gang Xu, Xiang-Cheng Li, Ke Wang, Xue-Hao Wang

Association of early-onset breast cancer with body mass index, menarche, and menopause in Taiwan

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Pei-Jing Yang, Ming-Feng Hou, Fu Ou-Yang, Eing-Mei Tsai, Tsu-Nai Wang

Elevated expression of RAB3B plays important roles in chemoresistance and metastatic potential of hepatoma cells

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Ryouichi Tsunedomi, Kiyoshi Yoshimura, Yuta Kimura, Mitsuo Nishiyama, Nobuyuki Fujiwara, Satoshi Matsukuma, Shinsuke Kanekiyo, Hiroto Matsui, Yoshitaro Shindo, Yusaku Watanabe, Yukio Tokumitsu, Shin Yoshida, Michihisa Iida, Nobuaki Suzuki, Shigeru Takeda, Tatsuya Ioka, Shoichi Hazama, Hiroaki Nagano

Additional capecitabine use in early-stage triple negative breast cancer patients receiving standard chemotherapy: a new era? A meta-analysis of randomized controlled trials

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Feng Ye, Lei Bian, Jiahuai Wen, Ping Yu, Na Li, Xiaoming Xie, Xi Wang

Pedigree investigation, clinical characteristics, and prognosis analysis of haematological disease patients with germline TET2 mutation

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Xia Wu, Jili Deng, Nanchen Zhang, Xiaoyan Liu, Xue Zheng, Tianyou Yan, Wu Ye, Yuping Gong

The targeted SMAC mimetic SW IV-134 augments platinum-based chemotherapy in pre-clinical models of ovarian cancer

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Pratibha S. Binder, Yassar M. Hashim, James Cripe, Tommy Buchanan, Abigail Zamorano, Suwanna Vangveravong, David G. Mutch, William G. Hawkins, Matthew A. Powell, Dirk Spitzer

A novel nine-microRNA-based model to improve prognosis prediction of renal cell carcinoma

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Chen Xu, Hui Zeng, Junli Fan, Wenjie Huang, Xiaosi Yu, Shiqi Li, Fubing Wang, Xinghua Long

Circ_0064288 acts as an oncogene of hepatocellular carcinoma cells by inhibiting miR-335-5p expression and promoting ROCK1 expression

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Yingying Nie, Xuedan Zhu, Nan Bu, Yang Jiang, Yue Su, Keming Pan, Shanshan Li

Overview of adjuvant radiotherapy on survival, failure pattern and toxicity in stage I to II endometrial carcinoma: a long-term multi-institutional analysis in China

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Wenhui Wang, Tiejun Wang, Zi Liu, Jianli He, Xiaoge Sun, Wei Zhong, Fengjv Zhao, Xiaomei Li, Sha Li, Hong Zhu, Zhanshu Ma, Ke Hu, Fuquan Zhang, Xiaorong Hou, Lichun Wei, Lijuan Zou

Late effects of high-dose methotrexate treatment in childhood cancer survivors—a systematic review

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Eveline Daetwyler, Mario Bargetzi, Maria Otth, Katrin Scheinemann

Adverse effects of cell-free and concentrated ascites reinfusion therapy for malignant ascites: a single-institute experience

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Misato Tsubokura, Yuko Adegawa, Minoru Kojima, Ryuji Tanosaki, Ryuzaburo Ohtake, Yuki Kase, Nao Iwashita, Moemi Kasane, Saori Nakabayashi, Sayaka Takeuchi, Ken Kato, Narikazu Boku, Yukihide Kanemitsu, Takuji Okusaka, Hiroyuki Fujimoto, Kan Yonemori, Hiroto Ishiki, Kimihiko Kawamura, Eriko Satomi, Hiromichi Matsushita

Rationale and design of a phase II trial of pyrotinib in combination with nab-paclitaxel as adjuvant therapy for N0/N1mi, HER2 + early breast cancer (PHAEDRA)

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• Study protocol

Changjun Wang, Yidong Zhou, Yan Lin, Feng Mao, Jinghong Guan, Xiaohui Zhang, Songjie Shen, Xuejing Wang, Yanna Zhang, Bo Pan, Ying Zhong, Li Peng, Xi Cao, Ru Yao, Xingtong Zhou, Chi Xu, Ying Xu, Qiang Sun

Transarterial chemoembolization combined with camrelizumab for recurrent hepatocellular carcinoma

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Yusheng Guo, Yanqiao Ren, Lei Chen, Tao Sun, Weihua Zhang, Bo Sun, Licheng Zhu, Fu Xiong, Chuansheng Zheng

The efficacy of human epidermal growth factor receptor 2 (HER2) blockade switching mode in refractory patients with HER2-positive metastatic breast cancer: a phase II, multicenter, single-arm study (SYSUCC-005)

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Fangfang Duan, Muyi Zhong, Yuyu Ma, Chenge Song, Lehong Zhang, Ying Lin, Zhiyong Wu, Yuanqi Zhang, Jiajia Huang, Fei Xu, Yanxia Shi, Shusen Wang, Zhongyu Yuan, Wen Xia, Xiwen Bi

Retraction Note: Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells

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• Retraction Note

Bin Wu, Ji Li, Damao Huang, Weiwei Wang, Yu Chen, Youxiang Liao, Xiaowei Tang, Hongfu Xie, Faqing Tang

Mendelian randomization study of circulating lipids and biliary tract cancer among East Asians

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Jun Wang, Jinke Zhuge, Dongxu Feng, Bo Zhang, Jianying Xu, Dongkang Zhao, Zhewei Fei, Xia Huang, Wenjie Shi

Short-course radiotherapy combined with CAPOX and Toripalimab for the total neoadjuvant therapy of locally advanced rectal cancer: a randomized, prospective, multicentre, double-arm, phase II trial (TORCH)

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• Study protocol

Yaqi Wang, Lijun Shen, Juefeng Wan, Hui Zhang, Ruiyan Wu, Jingwen Wang, Yan Wang, Ye Xu, Sanjun Cai, Zhen Zhang, Fan Xia

Patient-reported outcome (PRO) results from the AGITG DOCTOR trial: a randomised phase 2 trial of tailored neoadjuvant therapy for resectable oesophageal adenocarcinoma

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R. Mercieca-Bebber, E. H. Barnes, K. Wilson, Z. Samoon, E. Walpole, T. Mai, S. Ackland, M. Burge, G. Dickie, D. Watson, J. Leung, T. Wang, R. Bohmer, D. Cameron, J. Simes, V. Gebski, M. Smithers, J. Thomas, J. Zalcberg, A. P. Barbour

Recurrent brain metastases: the role of resection of in a comprehensive multidisciplinary treatment setting

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Nadine Heßler, Stephanie T. Jünger, Anna-Katharina Meissner, Martin Kocher, Roland Goldbrunner, Stefan Grau

Response rate of anticancer drugs approved by the Food and Drug Administration based on a single-arm trial

• Open Access
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Yoshihiro Oda, Mamoru Narukawa

Assessment of transparency and selective reporting of interventional trials studying colorectal cancer

• Open Access
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Anna Pellat, Isabelle Boutron, Philippe Ravaud

Serum exosomal proteomics analysis of lung adenocarcinoma to discover new tumor markers

• Open Access
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Shanshan Liu, Wenjuan Tian, Yuefeng Ma, Jiaji Li, Jun Yang, Burong Li

The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients

• Open Access
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Keisuke Goto, Masaki Morimoto, Mitsuhiko Osaki, Akimitsu Tanio, Runa Izutsu, Yoshiyuki Fujiwara, Futoshi Okada

New method for determining breast cancer recurrence-free survival using routinely collected real-world health data

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Hyunmin Jung, Mingshan Lu, May Lynn Quan, Winson Y. Cheung, Shiying Kong, Sasha Lupichuk, Yuanchao Feng, Yuan Xu

Gene signature associated with resistance to fluvastatin chemoprevention for breast cancer

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Anjana Bhardwaj, Matthew D. Embury, Zhenlin Ju, Jing Wang, Isabelle Bedrosian

Mapping disadvantage: identifying inequities in functional outcomes for prostate cancer survivors based on geography

• Open Access
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Kendrick Koo, Nathan Papa, Melanie Evans, Michael Jefford, Maarten IJzerman, Victoria White, Sue M. Evans, Eli Ristevski, Jon Emery, Jeremy Millar

Clinical significance of Osaka prognostic score based on nutritional and inflammatory status in patients with esophageal squamous cell carcinoma

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Jifeng Feng, Lifen Wang, Liang Wang, Xun Yang, Guangyuan Lou

Peri-tumoural spatial distribution of lipid composition and tubule formation in breast cancer

• Open Access
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Kwok-Shing Chan, Sai Man Cheung, Nicholas Senn, Ehab Husain, Yazan Masannat, Steven Heys, Jiabao He

Quality and efficacy of Multidisciplinary Team (MDT) quality assessment tools and discussion checklists: a systematic review

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George T. F. Brown, Hilary L. Bekker, Alastair L. Young

Risk of hepatocellular carcinoma in antiviral treatment-naïve chronic hepatitis B patients treated with entecavir or tenofovir disoproxil fumarate: a network meta-analysis

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Ze-Hong Huang, Gui-Yang Lu, Ling-Xian Qiu, Guo-Hua Zhong, Yue Huang, Xing-Mei Yao, Xiao-Hui Liu, Shou-Jie Huang, Ting Wu, Quan Yuan, Ying-Bin Wang, Ying-Ying Su, Jun Zhang, Ning-Shao Xia

Osteoclasts differential-related prognostic biomarker for osteosarcoma based on single cell, bulk cell and gene expression datasets

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Haiyu Shao, Meng Ge, Jun Zhang, Tingxiao Zhao, Shuijun Zhang

Increased expression of Nrf2 and elevated glucose uptake in pheochromocytoma and paraganglioma with SDHB gene mutation

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Takao Kamai, Satoshi Murakami, Kyoko Arai, Daisaku Nishihara, Toshitaka Uematsu, Kazuyuki Ishida, Toshiki Kijima

Log odds of positive lymph nodes as a novel prognostic predictor for colorectal cancer: a systematic review and meta-analysis

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Yiding Li, Guiling Wu, Yujie Zhang, Ben Han, Wanli Yang, Xiaoqian Wang, Lili Duan, Liaoran Niu, Junfeng Chen, Wei Zhou, Jinqiang Liu, Daiming Fan, Liu Hong

New diagnosis of cancer in mild and moderate/severe traumatic brain injury patients in a 12-year population-based study

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Chung-Che Lu, Tee-Tau Eric Nyam, Chung-Han Ho, Jinn-Rung Kuo, Chung-Ching Chio, Jhi-Joung Wang, Che-Chuan Wang

Clinical and economic impact of ‘ROS1-testing’ strategy compared to a ‘no-ROS1-testing’ strategy in advanced NSCLC in Spain

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Federico Rojo, Esther Conde, Héctor Torres, Luis Cabezón-Gutiérrez, Dolores Bautista, Inmaculada Ramos, David Carcedo, Natalia Arrabal, J. Francisco García, Raquel Galán, Ernest Nadal

Real-world efficiency of lenvatinib plus PD-1 blockades in advanced hepatocellular carcinoma: an exploration for expanded indications

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Xuqi Sun, Qi Zhang, Jie Mei, Ziliang Yang, Minshan Chen, Tingbo Liang

Rationale and design of a phase II trial of dacomitinib in advanced non-small cell lung cancer patients with uncommon epidermal growth factor receptor mutations: a prospective and single arm study (DANCE study)

• Open Access
• Study protocol

Bo Zhang, Chunlei Shi, Zhiqiang Gao, Hua Zhong, Liwen Xiong, Aiqin Gu, Weimin Wang, Tianqing Chu, Wei Zhang, Huimin Wang, Xueyan Zhang, Runbo Zhong, Baohui Han

Risk of developing depression among breast cancer patients in Palestine

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Dana Sadaqa, Ahlam Farraj, Hani Naseef, Hamza Alsaid, Nimeh Al-Shami, Abdallah Damin AbuKhalil

Rising incidence of HPV positive oropharyngeal cancer in Taiwan between 1999 and 2014 where betel nut chewing is common

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Cheng-Ping Wang, Tseng-Cheng Chen, Wan-Lun Hsu, Jenn-Ren Hsiao, Peir-Rong Chen, Mu-Kuan Chen, Chun-Hung Hua, Ming-Hsui Tsai, Jenq-Yuh Ko, Pei-Jen Lou, Chun-Ju Chiang, Chen-Tu Wu, Yih-Leong Chang

Systematic analysis of the expression and prognostic value of ITPR1 and correlation with tumor infiltrating immune cells in breast cancer

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Bing Han, Fang Zhen, Xiu-Shuang Zheng, Jing Hu, Xue-Song Chen

Correlation of LAGE3 with unfavorable prognosis and promoting tumor development in HCC via PI3K/AKT/mTOR and Ras/RAF/MAPK pathways

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Yun Li, Hui Xiong

Using biological information to analyze potential miRNA-mRNA regulatory networks in the plasma of patients with non-small cell lung cancer

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Wei Zhang, Qian Zhang, Li Che, Zhefan Xie, Xingdong Cai, Ling Gong, Zhu Li, Daishun Liu, Shengming Liu

Expression of the preadipocyte marker ZFP423 is dysregulated between well-differentiated and dedifferentiated liposarcoma

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Thanh N. Dang, Rafael P. Tiongco, Loren M. Brown, Jessica L. Taylor, John M. Lyons, Frank H. Lau, Z. Elizabeth Floyd

Influence of radiation dose and predicted tumor invasion depth on local recurrence after definitive chemoradiotherapy for stage 0–I esophageal squamous cell carcinoma: a propensity score-weighted, retrospective, observational study

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Toshiki Ikawa, Ryu Ishihara, Katsunori Matsueda, Koji Konishi, Sachiko Yamamoto, Masahiro Morimoto, Naoyuki Kanayama, Teruki Teshima

Octogenarian patients with colon cancer – postoperative morbidity and mortality are the major challenges

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Øystein Høydahl, Tom-Harald Edna, Athanasios Xanthoulis, Stian Lydersen, Birger Henning Endreseth

Disparities in healthcare expenditures according to economic status in cancer patients undergoing end-of-life care

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Kyu-Tae Han, Woorim Kim, Seungju Kim

Real-world burden of adverse events for apalutamide- or enzalutamide-treated non-metastatic castration-resistant prostate cancer patients in the United States

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Arif Hussain, Shan Jiang, Della Varghese, Sreevalsa Appukkuttan, Nehemiah Kebede, Kajan Gnanasakthy, Cynthia Macahilig, Reg Waldeck, Shelby Corman

A multicenter prospective cohort study to evaluate feasibility of radio-frequency identification surgical guidance for nonpalpable breast lesions: design and rationale of the RFID Localizer 1 Trial

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Bianca M. den Dekker, Anke Christenhusz, Thijs van Dalen, Lisa M. Jongen, Margreet C. van der Schaaf, Anneriet E. Dassen, Ruud M. Pijnappel

Correction: Breast cancer screening in sub-Saharan Africa: a systematic review and ethical appraisal

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Yehoda M. Martei, Bege Dauda, Verna Vanderpuye

Lack of tumorigenesis and protumorigenic activity of human umbilical cord mesenchymal stem cells in NOD SCID mice

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Jie He, Xiang Yao, Ping Mo, Kai Wang, Zai-ling Yang, Ni-ni Tian, Xiang-qing Zhu, Jing Zhao, Rong-qing Pang, Guang-ping Ruan, Xing-hua Pan

MiR-106b-5p regulates esophageal squamous cell carcinoma progression by binding to HPGD

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Fan Yang, Zhanwen Sun, Dengyun Wang, Tian Du

Understanding breast cancer risk factors: is there any mismatch between laywomen perceptions and expert opinions

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E. Manouchehri, A. Taghipour, A. Ebadi, F. Homaei Shandiz, R. Latifnejad Roudsari

Effects of adding a neurokinin-1 receptor antagonist to 5 mg olanzapine, a 5-hydroxytryptamine-3 receptor antagonist, and dexamethasone for preventing carboplatin-induced nausea and vomiting: a propensity score-matched analysis

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Senri Yamamoto, Hirotoshi Iihara, Ryuji Uozumi, Hitoshi Kawazoe, Kazuki Tanaka, Yukiyoshi Fujita, Masakazu Abe, Hisao Imai, Masato Karayama, Yoh Hayasaki, Chiemi Hirose, Takafumi Suda, Kazuto Nakamura, Akio Suzuki, Yasushi Ohno, Ken-ichirou Morishige, Naoki Inui

A simple CD4+ T cells to FIB-4 ratio for evaluating prognosis of BCLC-B hepatocellular carcinoma: a retrospective cohort study

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Yong Zhao, Ling Xiang Kong, Feng Shi Feng, Jiayin Yang, Guo Wei

PARP inhibitors chemopotentiate and synergize with cisplatin to inhibit bladder cancer cell survival and tumor growth

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Sayani Bhattacharjee, Matthew J. Sullivan, Rebecca R. Wynn, Alex Demagall, Andrew S. Hendrix, Puneet Sindhwani, Firas G. Petros, Nagalakshmi Nadiminty

Circ_0058063 contributes to cisplatin-resistance of bladder cancer cells by upregulating B2M through acting as RNA sponges for miR-335-5p

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Ming Sun, Xuefeng Liu, Wenyan Zhao, Bin Zhang, Peng Deng

Serum untargeted lipidomics by UHPLC-ESI-HRMS aids the biomarker discovery of colorectal adenoma

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Hailin Zhou, Yanying Nong, Yifan Zhu, Yunxiao Liang, Jiahao Zhang, Hongwei Chen, Pingchuan Zhu, Qisong Zhang

Pre-diagnostic faecal calprotectin levels in patients with colorectal cancer: a retrospective study

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Nathalie Blad, Richard Palmqvist, Pontus Karling

Comprehensive analysis of tumor immune microenvironment and prognosis of m6A-related lncRNAs in gastric cancer

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Yi Wang, Gui-Qi Zhu, Di Tian, Chang-Wu Zhou, Na Li, Ying Feng, Meng-Su Zeng

Longitudinal changes of blood parameters and weight in inoperable stage III NSCLC patients treated with concurrent chemoradiotherapy followed by maintenance treatment with durvalumab

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J. Guggenberger, S. Kenndoff, J. Taugner, L. Käsmann, B. Flörsch, C. Belka, C. Eze, F. Manapov

The abdominal-transhiatal surgical approach versus the thoracoabdominal surgical approach in Siewert type II adenocarcinoma of the esophagogastric junction: protocol for a multicenter prospective, open, parallel, and randomized controlled trial

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Qiying Song, Xiongguang Li, Di Wu, Shuo Li, Tianyu Xie, Yixun Lu, Liyu Zhang, Ziyao Xu, Lu Liu, Xin Guo, Xinxin Wang

Routes of administration, reasons for use, and approved indications of medical cannabis in oncology: a scoping review

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Billy Vinette, José Côté, Ali El-Akhras, Hazar Mrad, Gabrielle Chicoine, Karine Bilodeau

Context dependent isoform specific PI3K inhibition confers drug resistance in hepatocellular carcinoma cells

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Kubra Narci, Deniz Cansen Kahraman, Altay Koyas, Tulin Ersahin, Nurcan Tuncbag, Rengul Cetin Atalay

Clinic and genetic similarity assessments of atypical carcinoid, neuroendocrine neoplasm with atypical carcinoid morphology and elevated mitotic count and large cell neuroendocrine carcinoma

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Ying Zhang, Weiya Wang, Qianrong Hu, Zuoyu Liang, Ping Zhou, Yuan Tang, Lili Jiang

Pan-cancer analysis identifies BIRC5 as a prognostic biomarker

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Anna Fäldt Beding, Peter Larsson, Khalil Helou, Zakaria Einbeigi, Toshima Z. Parris

Survival past five years with advanced, EGFR-mutated or ALK-rearranged non-small cell lung cancer—is there a “tail plateau” in the survival curve of these patients?

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Shoko Sonobe Shimamura, Takehito Shukuya, Tetsuhiko Asao, Daisuke Hayakawa, Kana Kurokawa, Shiting Xu, Keita Miura, Yoichiro Mitsuishi, Ken Tajima, Rina Shibayama, Naoko Shimada, Fumiyuki Takahashi, Kazuhisa Takahashi

Retraction Note: Identification of novel signaling components in N,N’-Dinitrosopiperazine-mediated metastasis of nasopharyngeal Carcinoma by quantitative phosphoproteomics

• Open Access
• Retraction Note

Damao Huang, Yuejin Li, Na Liu, Zhenlin Zhang, Zhengke Peng, Chaojun Duan, Xiaowei Tang, Gongjun Tan, Guangrong Yan, Faqing Tang

Protein-based prognostic signature for predicting the survival and immunotherapeutic efficiency of endometrial carcinoma

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Jinzhi Lai, Tianwen Xu, Hainan Yang

Comparison of survival outcomes between squamous cell carcinoma and adenocarcinoma/adenosquamous carcinoma of the cervix after radical radiotherapy and chemotherapy

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Ping Liu, Mei Ji, Yanxiang Kong, Zhifeng Huo, Qiubo Lv, Qinghuang Xie, Danbo Wang, Biliang Chen, Hailin Wang, Zhumei Cui, Qianqing Wang, Xiaonong Bin, Jinghe Lang, Chunlin Chen

Skeletal muscle loss during neoadjuvant chemotherapy predicts poor prognosis in patients with breast cancer

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Masatsugu Amitani, Takaaki Oba, Nami Kiyosawa, Hiroki Morikawa, Tatsunori Chino, Ai Soma, Tadafumi Shimizu, Koichi Ohno, Mayu Ono, Tokiko Ito, Toshiharu Kanai, Kazuma Maeno, Ken-ichi Ito

Efficacy and safety of adjuvant EGFR-TKIs for resected non-small cell lung cancer: a systematic review and meta-analysis based on randomized control trials

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Pengfei Zhao, Hongchao Zhen, Hong Zhao, Lei Zhao, Bangwei Cao

Recurrence and prognosis in intrahepatic cholangiocarcinoma patients with different etiology after radical resection: a multi-institutional study

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Qi Li, Chen Chen, Jingbo Su, Yinghe Qiu, Hong Wu, Tianqiang Song, Xianhai Mao, Yu He, Zhangjun Cheng, Jingdong Li, Wenlong Zhai, Dong Zhang, Zhimin Geng, Zhaohui Tang

Prognostic significance of SNCA and its methylation in bladder cancer

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Zhengcun Wu, Chengxing Xia, Chao Zhang, Delin Yang, Kaili Ma

Safety and efficacy study of laparoscopic or robotic radical surgery using an endoscopic stapler for inhibiting tumour spillage of cervical malignant neoplasms evaluating survival (SOLUTION): a multi-centre, open-label, single-arm, phase II trial protocol

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• Study protocol

Soo Jin Park, Tae Wook Kong, Taehun Kim, Maria Lee, Chel Hun Choi, Seung-Hyuk Shim, Ga Won Yim, Seungmee Lee, Eun Ji Lee, Myong Cheol Lim, Suk-Joon Chang, Sung Jong Lee, San Hui Lee, Taejong Song, Yoo-Young Lee, Hee Seung Kim, Eun Ji Nam

Hsa-miR-181a-5p, hsa-miR-182-5p, and hsa-miR-26a-5p as potential biomarkers for BCR-ABL1 among adult chronic myeloid leukemia treated with tyrosine kinase inhibitors at the molecular response

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Aliza Mohd Yacob, Nor Asiah Muhamad, Kian Meng Chang, Hamidah Akmal Hisham, Yuslina Mat Yusoff, Latifah Ibrahim

Prognostic variables for conditional survival in patients with esophageal squamous cell carcinoma who underwent minimally invasive surgery

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Mingqiang Liang, Jiazhou Xiao, Maohui Chen, Bin Zheng, Chun Chen

N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease

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Lucy K. Shewell, Christopher J. Day, Jamie R. Kutasovic, Jodie L. Abrahams, Jing Wang, Jessica Poole, Colleen Niland, Kaltin Ferguson, Jodi M. Saunus, Sunil R. Lakhani, Mark von Itzstein, James C. Paton, Adrienne W. Paton, Michael P. Jennings

Late combination of transarterial chemoembolization with apatinib and camrelizumab for unresectable hepatocellular carcinoma is superior to early combination

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Shuguang Ju, Chen Zhou, Junwen Hu, Yingliang Wang, Chaoyang Wang, Jiacheng Liu, Chongtu Yang, Songjiang Huang, Tongqiang Li, Yang Chen, Yaowei Bai, Wei Yao, Bin Xiong

The impact of neurological performance and volumetrics on overall survival in brain metastasis in colorectal cancer: a retrospective single-center case series

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Caroline Sander, Clara Frydrychowicz, Gordian Prasse, Sabine Taubenheim, Felix Arlt, Jürgen Meixensberger, Michael Karl Fehrenbach

Feasibility, pitfalls and results of a structured concept-development phase for a randomized controlled phase III trial on radiotherapy in primary prostate cancer patients

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S. K. B. Spohn, S. Adebahr, M. Huber, C. Jenkner, R. Wiehle, B. Nagavci, C. Schmucker, E. G. Carl, R. C. Chen, W. A. Weber, M. Mix, A. Rühle, T. Sprave, N. H. Nicolay, C. Gratzke, M. Benndorf, T. Wiegel, J. Weis, D. Baltas, A. L. Grosu, C. Zamboglou

Biomechanical modelling of the pelvic system: improving the accuracy of the location of neoplasms in MRI-TRUS fusion prostate biopsy

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Muhammad Qasim, Dolors Puigjaner, Joan Herrero, Josep M. López, Carme Olivé, Gerard Fortuny, Josep Garcia-Bennett

NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer

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Xiaohua Zhu, YingYing Xie, Wenyan Huang, Zigui Chen, SuiQun Guo

A pilot study of game-based learning programs for childhood cancer survivors

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Daisuke Masumoto, Etsuko Nakagami-Yamaguchi, Misako Nambu, Miho Maeda, Hideko Uryu, Akira Hayakawa, Zayar Linn, Satoshi Okamura, Kosuke Kurihara, Kentaro Kihira, Takao Deguchi, Hiroki Hori

Suppressive effect of α-mangostin for cancer stem cells in colorectal cancer via the Notch pathway

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Min Kyoung Jo, Chang Mo Moon, Eun Ju Kim, Ji-Hee Kwon, Xiang Fei, Seong-Eun Kim, Sung-Ae Jung, Minsuk Kim, Yeung-Chul Mun, Young-Ho Ahn, Seung-Yong Seo, Tae Il Kim

Efficacy of platinum agents for stage III non-small-cell lung cancer following platinum-based chemoradiotherapy: a retrospective study

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Eriko Miyawaki, Hirotsugu Kenmotsu, Yasushi Shintani, Ikuo Sekine, Takehito Shukuya, Koichi Takayama, Akira Inoue, Isamu Okamoto, Katsuyuki Kiura, Kazuhisa Takahashi, Nobuyuki Yamamoto, Tomoya Kawaguchi, Etsuo Miyaoka, Ichiro Yoshino, Hiroshi Date

Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer

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Jan Bieńkiewicz, Hanna Romanowicz, Bożena Szymańska, Daria Domańska-Senderowska, Miłosz Wilczyński, Anna Stepowicz, Andrzej Malinowski, Beata Smolarz

LncRNA CALML3-AS1 suppresses papillary thyroid cancer progression via sponging miR-20a-5p/RBM38 axis

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Xiaozhou Zhang, Xiaojian Zhang, Qian Jia, Hongqiang Li, Runsheng Ma, Guang Yang, Fengyan Yin, Nannan Jiang, Detao Yin

Synergistic association between underweight and type 2 diabetes on the development of laryngeal cancer: a national population-based retrospective cohort study

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Oh. Hyeong Lee, Yong-Moon Park, Seung-Hyun Ko, Kyuna Lee, Yeonji Kim, Kyungdo Han, Jung-Hae Cho

Bevacizumab versus PARP-inhibitors in women with newly diagnosed ovarian cancer: a network meta-analysis

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Young Ju Suh, Banghyun Lee, Kidong Kim, Yujin Jeong, Hwa Yeon Choi, Sung Ook Hwang, Yong Beom Kim

High expression of p62/SQSTM1 predicts shorter survival for patients with pancreatic cancer

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Eva Philipson, Cecilia Engström, Peter Naredi, Johan Bourghardt Fagman

A preliminary study on the diagnostic value of PSADR, DPC and TSRP in the distinction of prostatitis and prostate cancer

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Minxin He, Li Wang, Hong Wang, Fang Liu, Mingrui Li, Tie Chong, Li Xue

Irinotecan plus temozolomide in relapsed Ewing sarcoma: an integrated analysis of retrospective studies

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Bi-Cheng Wang, Bo-Ya Xiao, Guo-He Lin

Correction: Psychotropic and anti-epileptic drug use, before and after surgery, among patients with low-grade glioma: a nationwide matched cohort study

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• Correction

Isabelle Rydén, Erik Thurin, Louise Carstam, Anja Smits, Sasha Gulati, Roger Henriksson, Øyvind Salvesen, Asgeir Store Jakola

MiR-509-3p is oncogenic, targets the tumor suppressor PHLPP2, and functions as a novel tumor adjacent normal tissue based prognostic biomarker in colorectal cancer

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Deepak Narayanan Iyer, Dominic Chi-Chung Foo, Oswens Siu-Hung Lo, Timothy Ming-Hun Wan, Xue Li, Ryan Wai-Yan Sin, Roberta Wen-Chi Pang, Wai-Lun Law, Lui Ng

Transcriptome analysis reveals the prognostic and immune infiltration characteristics of glycolysis and hypoxia in head and neck squamous cell carcinoma

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Jun Liu, Jianjun Lu, Wenli Li

Causal relationship between genetically predicted depression and cancer risk: a two-sample bi-directional mendelian randomization

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Guang-Li Zhu, Cheng Xu, Kai-bin Yang, Si-Qi Tang, Ling-Long Tang, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Jun Ma

Clinicopathological and ultrasound features as risk stratification predictors of clinical and pathological nodal status in papillary thyroid carcinoma: a study of 748 patients

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Cui Zhang, Baojun Li, Lei Zhang, Fengjiao Chen, Yanhua Zhang, Wen Cheng

Clinicopathological features of HER2 positive metastatic colorectal cancer and survival analysis of anti-HER2 treatment

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Liu Yang, Wenfei Li, Zhihao Lu, Ming Lu, Jun Zhou, Zhi Peng, Xiaotian Zhang, Xicheng Wang, Lin Shen, Jian Li

Long-term survival among colorectal cancer patients in Finland, 1991–2015: a nationwide population-based registry study

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Tobias Olenius, Laura Koskenvuo, Selja Koskensalo, Anna Lepistö, Camilla Böckelman

Application of One-Step Nucleic Acid Amplification (OSNA) in different cancer entities and usefulness in prostate cancer: a systematic review

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Mercè Cuadras, Jacques Planas, Ana Celma, Lucas Regis, Inés M. de Torres, M. Eugenia Semidey, Enrique Trilla, Juan Morote

Single fraction ablative preoperative radiation treatment for early-stage breast cancer: the CRYSTAL study – a phase I/II clinical trial protocol

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• Study protocol

Maria Alessia Zerella, Mattia Zaffaroni, Giuseppe Ronci, Samantha Dicuonzo, Damaris Patricia Rojas, Anna Morra, Cristiana Fodor, Elena Rondi, Sabrina Vigorito, Francesca Botta, Marta Cremonesi, Cristina Garibaldi, Silvia Penco, Viviana Enrica Galimberti, Mattia Intra, Sara Gandini, Massimo Barberis, Giuseppe Renne, Federica Cattani, Paolo Veronesi, Roberto Orecchia, Barbara Alicja Jereczek-Fossa, Maria Cristina Leonardi

FIRE-9 – PORT / AIO-KRK-0418: a prospective, randomized, open, multicenter Phase III trial to investigate the efficacy of adjuvant/additive chemotherapy in patients with definitely-treated metastatic colorectal cancer

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Nathanael Raschzok, Sebastian Stintzing, Volker Heinemann, Geraldine Rauch, Jens Ricke, Matthias Guckenberger, Annika Kurreck, Annabel H. S. Alig, Arndt Stahler, Lars Bullinger, Moritz Schmelzle, Wenzel Schöning, Georg Lurje, Felix Krenzien, Oliver Haase, Beate Rau, Bernhard Gebauer, Igor M. Sauer, Johann Pratschke, Dominik P. Modest

The benefits and acceptability of virtual reality interventions for women with metastatic breast cancer in their homes; a pilot randomised trial

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Lisa M. Reynolds, Alana Cavadino, Stanley Chin, Zoë Little, Amelia Akroyd, Geraldine Tennant, Rosie Dobson, Reuben Broom, Adèle Gautier

Intraepithelial lymphocytes are indicators of better prognosis in surgically resected endometrioid-type endometrial carcinomas at early and advanced stages

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Takako Kono-Sato, Kosuke Miyai, Yoji Yamagishi, Morikazu Miyamoto, Masashi Takano, Susumu Matsukuma, Kimiya Sato, Hitoshi Tsuda

Observation of the cervical microbiome in the progression of cervical intraepithelial neoplasia

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He Wang, Yanming Jiang, Yuejuan Liang, Lingjia Wei, Wei Zhang, Li Li

Downregulation of KRAB zinc finger proteins in 5-fluorouracil resistant colorectal cancer cells

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Anaïs Chauvin, Danny Bergeron, Jean Vencic, Dominique Lévesque, Benoit Paquette, Michelle S. Scott, François-Michel Boisvert

Durvalumab after chemoradiotherapy for locally advanced non-small cell lung cancer prolonged distant metastasis-free survival, progression-free survival and overall survival in clinical practice

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Takaya Yamamoto, Yoko Tsukita, Yu Katagiri, Haruo Matsushita, Rei Umezawa, Yojiro Ishikawa, Noriyoshi Takahashi, Yu Suzuki, Kazuya Takeda, Eisaku Miyauchi, Ryota Saito, Yoshiyuki Katsuta, Noriyuki Kadoya, Keiichi Jingu

A new risk model based on a 11-m6A-related lncRNA signature for predicting prognosis and monitoring immunotherapy for gastric cancer

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Liangliang Lei, Nannan Li, Pengfei Yuan, Dechun Liu

HOXA-AS2 enhances GBM cell malignancy by suppressing miR-2116-3p thereby upregulating SERPINA3

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Jianrui Sun, Lin Wang

Concomitant Temozolomide plus radiotherapy for high-grade and recurrent meningioma: a retrospective chart review

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Katherine Belanger, Timothy H. Ung, Denise Damek, Kevin O. Lillehei, D. Ryan Ormond

Utility of prognostic nutritional index and systemic immune-inflammation index in oral cancer treatment

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Kosei Kubota, Ryohei Ito, Norihiko Narita, Yusuke Tanaka, Ken Furudate, Natsumi Akiyama, Chuang Hao Chih, Shotaro Komatsu, Wataru Kobayashi

Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer

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Lavanya Sivapalan, Graeme J. Thorn, Emanuela Gadaleta, Hemant M. Kocher, Helen Ross-Adams, Claude Chelala

TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway

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Liuyan Chen, Jilin Qing, Yangyang Xiao, Xiaomei Huang, Yanlin Chi, Zhizhong Chen

Age as a potential predictor of acute side effects during chemoradiotherapy in primary cervical cancer patients

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Annica Holmqvist, Gabriel Lindahl, Rasmus Mikivier, Srinivas Uppungunduri

KCNQ1 and lymphovascular invasion are key features in a prognostic classifier for stage II and III colon cancer

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Sjoerd H. Uil, Veerle M. H. Coupé, Herman Bril, Gerrit A. Meijer, Remond J. A. Fijneman, Hein B. A. C. Stockmann

RETRACTED ARTICLE: The circular RNA circFARSA sponges microRNA-330-5p in tumor cells with bladder cancer phenotype

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Chen Fang, Xin Huang, Jun Dai, Wei He, Le Xu, Fukang Sun

Development and validation of polygenic risk scores for prediction of breast cancer and breast cancer subtypes in Chinese women

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Can Hou, Bin Xu, Yu Hao, Daowen Yang, Huan Song, Jiayuan Li

The prognostic potential of alkaline phosphatase and lactic acid dehydrogenase in bmCRPC patients without significant PSA response under enzalutamide

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Renata Poteska, Kambiz Rahbar, Axel Semjonow, Andres Jan Schrader, Martin Boegemann, Katrin Schlack

High ratio of pCXCR4/CXCR4 tumor infiltrating immune cells in primary high grade ovarian cancer is indicative for response to chemotherapy

• Open Access
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Fabio Walther, Jana Ladina Berther, Alexandros Lalos, Michaela Ramser, Simone Eichelberger, Robert Mechera, Savas Soysal, Simone Muenst, Alberto Posabella, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano, Raoul A. Droeser, Jasmin Zeindler, Gad Singer

Safety and efficacy of cabozantinib for patients with advanced hepatocellular carcinoma who advanced to Child–Pugh B liver function at study week 8: a retrospective analysis of the CELESTIAL randomised controlled trial

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Anthony B. El-Khoueiry, Tim Meyer, Ann-Lii Cheng, Lorenza Rimassa, Suvajit Sen, Steven Milwee, Robin Kate Kelley, Ghassan K. Abou-Alfa

Predictive biomarkers for the efficacy of nivolumab as ≥ 3rd-line therapy in patients with advanced gastric cancer: a subset analysis of ATTRACTION-2 phase III trial

• Open Access
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Jwa Hoon Kim, Min-Hee Ryu, Young Soo Park, Jungeun Ma, Sun Young Lee, Deokhoon Kim, Yoon-Koo Kang

A new nomogram model for prognosis of hepatocellular carcinoma based on novel gene signature that regulates cross-talk between immune and tumor cells

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Youpeng Wang, Yeni Yang, Ziyin Zhao, Hongfa Sun, Dingan Luo, Lakshmi Huttad, Bingyuan Zhang, Bing Han

A new finding in the key prognosis-related proto-oncogene FYN in hepatocellular carcinoma based on the WGCNA hub-gene screening trategy

• Open Access
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Chenkai Huang, Juanjuan Zhou, Yuan Nie, Guihai Guo, Anjiang Wang, Xuan Zhu

Tivozanib in renal cell carcinoma: a systematic review of the evidence and its dissemination in the scientific literature

• Open Access
• Research article

Laura Caquelin, Mohamed Gewily, Wendy Mottais, Chloé Tebaldi, Bruno Laviolle, Florian Naudet, Clara Locher

Diagnostic value of circulating genetically abnormal cells to support computed tomography for benign and malignant pulmonary nodules

• Open Access
• Research article

Han Yang, Hongjie Chen, Guorui Zhang, Hongyi Li, Ran Ni, Yali Yu, Yepeng Zhang, Yongjun Wu, Hong Liu

Supportive oncology care at home interventions: protocols for clinical trials to shift the paradigm of care for patients with cancer

• Open Access
• Study protocol

Ryan D. Nipp, Eliza Shulman, Melissa Smith, Patricia M. C. Brown, P. Connor Johnson, Eva Gaufberg, Charu Vyas, Carolyn L. Qian, Isabel Neckermann, Shira B. Hornstein, Mathew J. Reynolds, Joseph Greer, Jennifer S. Temel, Areej El-Jawahri

A multicenter noninferior randomized controlled study comparing the efficacy of laparoscopic versus abdominal radical hysterectomy for cervical cancer (stage IA1 with LVSI, IA2): study protocol of the LAUNCH 1 trial

• Open Access
• Study protocol

Xin Wu, Hao Feng, Shujun Gao, Hua Feng, Wenjing Diao, Hongwei Zhang, Ming Du, Weihua Lou, Xipeng Wang, Tao Zhu, Yuyang Zhang, Weiguo Hu, Xiaohong Xue, Zhiling Zhu, Libing Xiang, Jiarui Li, Xuhong Fang, Yongrui Bai, Yanli Hou, Weili Yan, Ling Qiu, Hailin Yu, Shurong Zhu, Yan Du, Hua Jiang

Association between age at initial diagnosis and post-metastasis mortality among women with recurrent metastatic breast cancer in China

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Yuxin Xie, Qiheng Gou, Yingjie Zhang, Keqi Xie, Dan Zheng, Chuanxu Luo, Jiaojiao Suo, Xiaorong Zhong, Ting Luo

Invadopodia play a role in prostate cancer progression

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Valeria Manuelli, Fidelma Cahill, Harriet Wylie, Cheryl Gillett, Isabel Correa, Susanne Heck, Alex Rimmer, Anna Haire, Mieke Van Hemelrijck, Sarah Rudman, Claire M. Wells

Assessment of the diagnostic and prognostic relevance of ACAT1 and CE levels in plasma, peritoneal fluid and tumor tissue of epithelial ovarian cancer patients - a pilot study

• Open Access
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Vijayalakshmi Ayyagari, Maio Li, Zvi Pasman, Xinjia Wang, Somaja Louis, Paula Diaz-Sylvester, Kathleen Groesch, Teresa Wilson, Laurent Brard

Improving colposcopic accuracy for cervical precancer detection: a retrospective multicenter study in China

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Bingrui Wei, Bo Zhang, Peng Xue, Samuel Seery, Jiaxu Wang, Qing Li, Yu Jiang, Youlin Qiao

LINC00511 enhances LUAD malignancy by upregulating GCNT3 via miR-195-5p

• Open Access
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Youyi Zhang, Ping Xiao, Xiaobo Hu

Risk factors for recurrence in elderly patients with stage II colorectal cancer: a multicenter retrospective study

• Open Access
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Takuki Yagyu, Manabu Yamamoto, Akimitsu Tanio, Kazushi Hara, Ken Sugezawa, Chihiro Uejima, Kyoichi Kihara, Shigeru Tatebe, Yasuro Kurisu, Shunsuke Shibata, Toshio Yamamoto, Hiroshi Nishie, Setsujo Shiota, Hiroaki Saito, Takuji Naka, Kenji Sugamura, Kuniyuki Katano, Yoshiyuki Fujiwara

The oncological safety of autologous fat grafting: a systematic review and meta-analysis

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Rodrigo Goncalves, Bruna Salani Mota, Bruno Sobreira-Lima, Marcos Desidério Ricci, José Maria Soares Jr, Alexandre Mendonça Munhoz, Edmund Chada Baracat, José Roberto Filassi

B4GALT5 high expression associated with poor prognosis of hepatocellular carcinoma

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Yang Han, Zhe Li, Qi Wu, Hui Liu, Zhiqiang Sun, Yong Wu, Judong Luo

Humanized CD19 CAR-T cells in relapsed/refractory B-ALL patients who relapsed after or failed murine CD19 CAR-T therapy

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Lihong An, Yuehui Lin, Biping Deng, Zhichao Yin, Defeng Zhao, Zhuojun Ling, Tong Wu, Yongqiang Zhao, Alex H. Chang, Chunrong Tong, Shuangyou Liu

Serum-based measurements of stromal activation through ADAM12 associate with poor prognosis in colorectal cancer

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Sanne ten Hoorn, Cynthia Waasdorp, Martijn G. H. van Oijen, Helene Damhofer, Anne Trinh, Lan Zhao, Lisanne J. H. Smits, Sanne Bootsma, Gabi W. van Pelt, Wilma E. Mesker, Linda Mol, Kaitlyn K. H. Goey, Miriam Koopman, Jan Paul Medema, Jurriaan B. Tuynman, Inti Zlobec, Cornelis J. A. Punt, Louis Vermeulen, Maarten F. Bijlsma

The effect of mannitol addition to hydration on acute kidney injury event after high dose cisplatin chemotherapy: an ambispective cohort study

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Andhika Rachman, Syahidatul Wafa, Pringgodigdo Nugroho, Sukamto Koesnoe

Genetic and RNA-related molecular markers of trastuzumab-chemotherapy-associated cardiotoxicity in HER2 positive breast cancer: a systematic review

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Mattia Lunardi, Ahmed Al-Habbaa, Mahmoud Abdelshafy, Matthew G. Davey, Ahmed Elkoumy, Sandra Ganly, Hesham Elzomor, Christian Cawley, Faisal Sharif, James Crowley, Michael Kerin, William Wijns, Aoife Lowery, Osama Soliman

Effect of neoadjuvant iodine-125 brachytherapy upon resection of glioma

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Congxiao Wang, Chao Liu, Jun Chen, Han Jiang, Wei Zhang, Lili Yang, Xueda Li, Zixiang Li, Lijing Peng, Xiaokun Hu, Peng Sun

The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature

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Anna Hagström, Ruba Kal Omar, Pete A. Williams, Gustav Stålhammar

Vegetable and fruit consumption and cancer of unknown primary risk: results from the Netherlands cohort study on diet and cancer

• Open Access
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Karlijn E. P. E. Hermans, Piet A. van den Brandt, Caroline Loef, Rob L. H. Jansen, Leo J. Schouten

HOX and PBX gene dysregulation as a therapeutic target in glioblastoma multiforme

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Einthavy Arunachalam, William Rogers, Guy R. Simpson, Carla Möller-Levet, Gemma Bolton, Mohammed Ismael, Christopher Smith, Karl Keegen, Izhar Bagwan, Tim Brend, Susan C. Short, Bangxing Hong, Yoshihiro Otani, Balveen Kaur, Nicola Annels, Richard Morgan, Hardev Pandha

Tumor histology is an independent prognostic factor in locally advanced cervical carcinoma: A retrospective study

• Open Access
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Lenny Gallardo-Alvarado, David Cantú-de León, Rebeca Ramirez-Morales, Gabriel Santiago-Concha, Salim Barquet-Muñoz, Rosa Salcedo-Hernandez, Cinthya Reyes, Sandra Perez-Alvarez, Delia Perez-Montiel, Carlos Perez-Plasencia, Elizabeth Trejo-Duran, Juan Pablo Galicia

Novel pathological predictive factors for extranodal extension in oral squamous cell carcinoma: a retrospective cohort study based on tumor budding, desmoplastic reaction, tumor-infiltrating lymphocytes, and depth of invasion

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Yuri Noda, Mitsuaki Ishida, Yasuhiro Ueno, Takuo Fujisawa, Hiroshi Iwai, Koji Tsuta

Four cycles of R-CHOP followed by two applications of rituximab based on negative interim PET/CT: an analysis of a prospective trial

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Jia Jin, Dongmei Ji, Zuguang Xia, Kai Xue, Qunling Zhang, Yizhen Liu, Junning Cao, Xiaonan Hong, Juan J. Gu, Ye Guo, Fangfang Lv

Molecular signatures of tumor progression in pancreatic adenocarcinoma identified by energy metabolism characteristics

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Cong Tan, Xin Wang, Xu Wang, Weiwei Weng, Shu-juan Ni, Meng Zhang, Hesheng Jiang, Lei Wang, Dan Huang, Weiqi Sheng, Mi-die Xu

Aberrant hydroxymethylation in promoter CpG regions of genes related to the cell cycle and apoptosis characterizes advanced chronic myeloid leukemia disease, poor imatinib respondents and poor survival

• Open Access
• Research article

Sameer Ahmad Guru, Mamta Pervin Sumi, Rashid Mir, Mirza Masroor Ali Beg, Bidhan Chandra koner, Alpana Saxena

SNCA correlates with immune infiltration and serves as a prognostic biomarker in lung adenocarcinoma

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Xiuao Zhang, Zhengcun Wu, Kaili Ma

Association of a novel 27-gene immuno-oncology assay with efficacy of immune checkpoint inhibitors in advanced non-small cell lung cancer

• Open Access
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Harsha Ranganath, Amit L. Jain, Justin R. Smith, Julie Ryder, Amina Chaudry, Emily Miller, Felicia Hare, Poojitha Valasareddy, Robert S. Seitz, David R. Hout, Matthew G. Varga, Brock L. Schweitzer, Tyler J. Nielsen, Janice Mullins, Douglas T. Ross, David R. Gandara, Gregory A. Vidal

Proteomics analysis: inhibiting the expression of P62 protein by chloroquine combined with dacarbazine can reduce the malignant progression of uveal melanoma

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Xifeng Fei, Xiangtong Xie, Ruwei Qin, Anqi Wang, Xuan Meng, Fei Sun, Yifan Zhao, Dongyi Jiang, Hanchun Chen, Qiang Huang, Xiaoyan Ji, Zhimin Wang

Retraction Note: Comparison of minimally invasive Ivor Lewis esophagectomy and left transthoracic esophagectomy in esophageal squamous cell carcinoma patients: a propensity score-matched analysis

• Open Access
• Retraction Note

Qi Wang, Zixiang Wu, Tianwei Zhan, Shuai Fang, Sai Zhang, Gang Shen, Ming Wu

Autophagy modulating therapeutics inhibit ovarian cancer colony generation by polyploid giant cancer cells (PGCCs)

• Open Access
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Robert R. Bowers, Maya F. Andrade, Christian M. Jones, Shai White-Gilbertson, Christina Voelkel-Johnson, Joe R. Delaney

Role of APOA1 in the resistance to platinum-based chemotherapy in squamous cervical cancer

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Yue He, Su-Bin Han, Yang Liu, Jing-Jing Zhang, Yu-Mei Wu

Diagnostic value of tumor markers in identifying favorable or unfavorable subsets in patients with cancer of unknown primary: a retrospective study

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Shigemasa Takamizawa, Tatsunori Shimoi, Masayuki Yoshida, Momoko Tokura, Shu Yazaki, Chiharu Mizoguchi, Ayumi Saito, Shosuke Kita, Kasumi Yamamoto, Yuki Kojima, Hitomi Sumiyoshi-Okuma, Tadaaki Nishikawa, Emi Noguchi, Kazuki Sudo, Kan Yonemori

Clinical application of liquid biopsy in cancer patients

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Chieh-Min Chang, Kuei-Ching Lin, Nien-En Hsiao, Wei-An Hong, Chia-Yu Lin, Ta-Chih Liu, Ya-Sian Chang, Jan-Gowth Chang

Exploring socio-demographic, physical, psychological, and quality of life-related factors related with fear of cancer recurrence in stomach cancer survivors: a cross-sectional study

• Open Access
• Research article

Jinyoung Shin, Dong Wook Shin, Jungkwon Lee, JiHye Hwang, Ji Eun Lee, BeLong Cho, Yun–Mi Song

A single arm phase II study of bone-targeted Sn-117 m-DTPA in symptomatic castration-resistant prostate cancer with skeletal metastases

• Open Access
• Study protocol

Zin W. Myint, Riham El Khouli, Bryan Lemieux, Donglin Yan, William H. St. Clair, Xiaoqi Liu, Charles A. Kunos

Phase III randomised controlled trial on PSMA PET/CT guided hypofractionated salvage prostate bed radiotherapy of biochemical failure after radical prostatectomy for prostate cancer (PERYTON-trial): study protocol

• Open Access
• Study protocol

F. H. E. Staal, J. Janssen, C. L. Brouwer, J. A. Langendijk, K. Ng Wei Siang, E. Schuit, I. J. de Jong, J. F. Verzijlbergen, R. J. Smeenk, S. Aluwini

Phase I study of [131I] ICF01012, a targeted radionuclide therapy, in metastatic melanoma: MELRIV-1 protocol

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• Study protocol

Emilie Thivat, Jacques Rouanet, Philippe Auzeloux, Nicolas Sas, Elodie Jouberton, Sophie Levesque, Tommy Billoux, Sandrine Mansard, Ioana Molnar, Marion Chanchou, Giovanna Fois, Lydia Maigne, Jean-Michel Chezal, Elisabeth Miot-Noirault, Michel D’Incan, Xavier Durando, Florent Cachin

CA19-9 in combination with P-CRP as a predictive marker of immune-related adverse events in patients with recurrent or unresectable advanced gastric cancer treated with nivolumab

• Open Access
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Tomoyuki Matsunaga, Hiroaki Saito, Hirohiko Kuroda, Tomohiro Osaki, Sadamu Takahashi, Akemi Iwamoto, Yoji Fukumoto, Kenjiro Taniguchi, Kenji Fukuda, Wataru Miyauchi, Yuji Shishido, Kozo Miyatani, Yoshiyuki Fujiwara

Disparities in the increases of cervical cancer incidence rates: observations from a city-wide population-based study

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Ke Li, Huan Xu, Suixiang Wang, Pengzhe Qin, Boheng Liang

Machine learning-based multiparametric MRI radiomics for predicting poor responders after neoadjuvant chemoradiotherapy in rectal Cancer patients

• Open Access
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Jia Wang, Jingjing Chen, Ruizhi Zhou, Yuanxiang Gao, Jie Li

Effects of HMGA2 on the epithelial-mesenchymal transition-related genes in ACHN renal cell carcinoma cells-derived xenografts in nude mice

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Ying Liu, Guangyao Lv, Jianxin Bai, Lingling Song, Elizabeth Ding, Lin Liu, Yuqin Tian, Qian Chen, Kai Li, Xianfeng Liu, Yan Ding

Correction: Tumor histology is an independent prognostic factor in locally advanced cervical carcinoma: A retrospective study

• Open Access
• Correction

Lenny Gallardo-Alvarado, David Cantú-de León, Rebeca Ramirez-Morales, Gabriel Santiago-Concha, Salim Barquet-Muñoz, Rosa Salcedo-Hernandez, Cinthya Reyes, Sandra Perez-Alvarez, Delia Perez-Montiel, Carlos Perez-Plasencia, Elizabeth Trejo-Duran, Juan Pablo Galicia

Activated TAZ induces liver cancer in collaboration with EGFR/HER2 signaling pathways

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Hyuk Moon, Hyunjung Park, Min Jee Chae, Hye Jin Choi, Do Young Kim, Simon Weonsang Ro

OLA1 promotes colorectal cancer tumorigenesis by activation of HIF1α/CA9 axis

• Open Access
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Yue Liu, Xiang-Xing Kong, Jin-Jie He, Yan-Bo Xu, Jian-Kun Zhang, Lu-Yang Zou, Ke-Feng Ding, Dong Xu

CT-707 overcomes hypoxia-mediated sorafenib resistance in Hepatocellular carcinoma by inhibiting YAP signaling

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Zibo Chen, Tao Yuan, Fangjie Yan, Song Ye, Qin Xie, Bo Zhang, Nengmin Lin, Qiaojun He, Bo Yang, Hong Zhu

A descriptive systematic review of the relationship between personality traits and quality of life of women with non-metastatic breast cancer

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Veerle Marieke Wintraecken, Sophie Vulik, Sabine de Wild, Carmen Dirksen, Linetta B. Koppert, Jolanda de Vries, Marjolein L. Smidt

Survival outcomes in endometrial cancer patients according to diabetes: a systematic review and meta-analysis

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Lauren McVicker, Christopher R. Cardwell, Lauren Edge, W Glenn McCluggage, Declan Quinn, James Wylie, Úna C. McMenamin

Baseline soluble MICA levels act as a predictive biomarker for the efficacy of regorafenib treatment in colorectal cancer

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Jun Arai, Yumi Otoyama, Ken-ichi Fujita, Kaku Goto, Masayuki Tojo, Atsushi Katagiri, Hisako Nozawa, Yutaro Kubota, Takehiro Takahashi, Hiroo Ishida, Takuya Tsunoda, Natsumi Matsumoto, Keita Ogawa, Ryo Nakagawa, Ryosuke Muroyama, Naoya Kato, Hitoshi Yoshida

Identification of a pyroptosis-related prognostic signature in breast cancer

• Open Access
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Hanghang Chen, Haihua Luo, Jieyan Wang, Jinming Li, Yong Jiang

Prognostic impact of angiotensin-converting enzyme inhibitors and angiotensin receptors blockers in esophageal or gastric cancer patients with hypertension - a real-world study

• Open Access
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Po-Chih Li, Ru-Yu Huang, Yu-Chien Yang, Kun-Pin Hsieh, Yi-Hsin Yang

Serum long non-coding RNA SCARNA10 serves as a potential diagnostic biomarker for hepatocellular carcinoma

• Open Access
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Yawei Han, Wenna Jiang, Yu Wang, Meng Zhao, Yueguo Li, Li Ren

Systemic treatment in patients with malignant pleural mesothelioma – real life experience

• Open Access
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Barbara Ziółkowska, Bożena Cybulska-Stopa, Dimitrios Papantoniou, Rafał Suwiński

Exploration of mRNAs and miRNA classifiers for various ATLL cancer subtypes using machine learning

• Open Access
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Mohadeseh Zarei Ghobadi, Rahman Emamzadeh, Elaheh Afsaneh

Symptoms, problems and quality of life in patients newly diagnosed with oesophageal and gastric cancer – a comparative study of treatment strategy

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Karin Dalhammar, Jimmie Kristensson, Dan Falkenback, Birgit H. Rasmussen, Marlene Malmström

Underdiagnosis of iron deficiency anemia among patients with colorectal cancer: an examination of electronic medical records

• Open Access
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Trishnee Bhurosy, Anika Jishan, Patrick M. Boland, Yen-Han Lee, Carolyn J. Heckman

Modular and mechanistic changes across stages of colorectal cancer

• Open Access
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Sara Rahiminejad, Mano R. Maurya, Kavitha Mukund, Shankar Subramaniam

Association between effector-type regulatory T cells and immune checkpoint expression on CD8+ T cells in malignant ascites from epithelial ovarian cancer

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Sho Sato, Hirokazu Matsushita, Daisuke Shintani, Yukari Kobayashi, Nao Fujieda, Akira Yabuno, Tadaaki Nishikawa, Keiichi Fujiwara, Kazuhiro Kakimi, Kosei Hasegawa

Construction of in vitro 3-D model for lung cancer-cell metastasis study

• Open Access
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Rongrong Jiang, Jiechun Huang, Xiaotian Sun, Xianglin Chu, Fangrui Wang, Jie Zhou, Qihui Fan, Liewen Pang

Correction: Aberrant hydroxymethylation in promoter CpG regions of genes related to the cell cycle and apoptosis characterizes advanced chronic myeloid leukemia disease, poor imatinib respondents and poor survival

• Open Access
• Correction

Sameer Ahmad Guru, Mamta Pervin Sumi, Rashid Mir, Mirza Masroor Ali Beg, Bidhan Chandra koner, Alpana Saxena

Impact of Resistance Exercise and Nutritional Endorsement on physical performance in patients with GvHD (IRENE-G study) – design and rational of a randomized controlled trial

• Open Access
• Study protocol

Janina Bujan Rivera, Rea Kühl, Ulrike Zech, Anne Hendricks, Thomas Luft, Peter Dreger, Birgit Friedmann-Bette, Theresa-Maria Betz, Joachim Wiskemann

Development, implementation and evaluation a palliative care program for colorectal cancer patients: a mixed methods protocol study

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• Study protocol

Masoud Bahrami, Masoumeh Masoumy, Alireza Sadeghi, Rohallah Mosavizadeh

Oral cryotherapy for management of chemotherapy‐induced oral mucositis in haematopoietic cell transplantation: a systematic review

• Open Access
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Faizah Jabr Alsulami, Sadr ul Shaheed

PRehabIlitatiOn with pReoperatIve exercise and educaTion for patients undergoing major abdominal cancer surgerY: protocol for a multicentre randomised controlled TRIAL (PRIORITY TRIAL)

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Daniel Steffens, Jane Young, Bernhard Riedel, Rachael Morton, Linda Denehy, Alexander Heriot, Cherry Koh, Qiang Li, Adrian Bauman, Charbel Sandroussi, Hilmy Ismail, Mbathio Dieng, Nabila Ansari, Neil Pillinger, Sarah O’Shannassy, Sam McKeown, Derek Cunningham, Kym Sheehan, Gino Iori, Jenna Bartyn, Michael Solomon

Association of histological features with laryngeal squamous cell carcinoma recurrences: a population-based study of 1502 patients in the Netherlands

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Lilian N. Ruiter, Boukje A. C. van Dijk, Annette H. Bruggink, Patricia A. H. Doornaert, Marielle E. P. Philippens, Remco de Bree, Carla H. van Gils, Stefan M. Willems

Sentinel lymph node procedure in patients with recurrent vulvar squamous cell carcinoma: a proposed protocol for a multicentre observational study

• Open Access
• Study Protocol

Helena C. van Doorn, Maaike H. M. Oonk, Guus Fons, Katja N. Gaarenstroom, Joanne de Hullu, Joost van Rosmalen, Heleen J. van Beekhuizen

Characterization of SN38-resistant T47D breast cancer cell sublines overexpressing BCRP, MRP1, MRP2, MRP3, and MRP4

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Hee-Jeong Lee, Cheol-Hee Choi

AXL regulates neuregulin1 expression leading to cetuximab resistance in head and neck cancer

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Mari Iida, Nellie K. McDaniel, Kourtney L. Kostecki, Noah B. Welke, Carlene A. Kranjac, Peng Liu, Colin Longhurst, Justine Y. Bruce, Seungpyo Hong, Ravi Salgia, Deric L. Wheeler

BIRC5 regulates inflammatory tumor microenvironment-induced aggravation of penile cancer development in vitro and in vivo

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Yang Zhao, Songlin Liu, Shuhang Li, Gang Zhang, Aimin Tian, Yinxu Wan

The frequency and clinical implication of mismatch repair protein deficiency in Chinese patients with ovarian clear cell carcinoma

• Open Access
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Shuang Ye, Shuling Zhou, Siyuan Zhong, Boer Shan, Wenhua Jiang, Wentao Yang, Xu Cai, Huijuan Yang

Development of a questionnaire to evaluate female fertility care in pediatric oncology, a TREL initiative

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M. E. Madeleine van der Perk, Eglė Stukaitė-Ruibienė, Žana Bumbulienė, Goda Elizabeta Vaitkevičienė, Annelies M. E. Bos, Marry M. van den Heuvel-Eibrink, Jelena Rascon

Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms

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Irene Kleinberger, Ellen Sanders, Katrien Staes, Marleen Van Troys, Shinji Hirano, Tino Hochepied, Kelly Lemeire, Liesbet Martens, Christophe Ampe, Frans van Roy

Association of institutional transition of cancer care with mortality in elderly patients with lung cancer: a retrospective cohort study using national claim data

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Kyu-Tae Han, Jongwha Chang, Dong-Woo Choi, Seungju Kim, Dong Jun Kim, Yoon-Jung Chang, Sun Jung Kim

LINC00022 acts as an oncogene in colorectal cancer progression via sponging miR-375-3p to regulate FOXF1 expression

• Open Access
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Lingling Xu, Hongmei He, Yu Shang, Xiaona Qu, Jinghua Sun

Comparison of five-year survival rates among patients with oral squamous cell carcinoma with and without association with syphilis: a retrospective case-control study

• Open Access
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Moritz Hertel, Leonie Hagedorn, Andrea Maria Schmidt-Westhausen, Henrik Dommisch, Max Heiland, Robert Preissner, Saskia Preissner

The value of preoperative sentinel lymph node contrast-enhanced ultrasound for breast cancer: a large, multicenter trial

• Open Access
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Juan Li, Hui Li, Ling Guan, Yun Lu, Weiwei Zhan, Yijie Dong, Peng Gu, Jian Liu, Wen Cheng, Ziyue Na, Lina Tang, Zhongshi Du, Lichun Yang, Saiping Hai, Chen Yang, Qingqiu Zheng, Yuhua Zhang, Shan Wang, Fang Li, Jing Fu, Man Lu

Cervical, vaginal and vulvar cancer incidence and survival trends in Denmark, Finland, Norway and Sweden with implications to treatment

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Kari Hemminki, Anna Kanerva, Asta Försti, Akseli Hemminki

Tryptophan hydroxylase 1 drives glioma progression by modulating the serotonin/L1CAM/NF-κB signaling pathway

• Open Access
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Jie Zhang, Zhangchao Guo, Qiangli Xie, Chuanhong Zhong, Xiangyu Gao, Qiumei Yang

Can upfront DPYD extended variant testing reduce toxicity and associated hospital costs of fluoropyrimidine chemotherapy? A propensity score matched analysis of 2022 UK patients

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Apostolos Tsiachristas, Grant Vallance, Rositsa Koleva-Kolarova, Harriet Taylor, Luke Solomons, Giovanni Rizzo, Catherine Chaytor, Junel Miah, Sarah Wordsworth, A. Bassim Hassan

Deletion of TRIB3 disrupts the tumor progression induced by integrin αvβ3 in lung cancer

• Open Access
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Wen Zhou, Junjun Ma, Lifeng Meng, Dabei Liu, Jun Chen

Oxaliplatin- versus cisplatin-based regimens for elderly individuals with advanced gastric cancer: a retrospective cohort study

• Open Access
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Takashi Chinen, Yusuke Sasabuchi, Hiroki Matsui, Hironori Yamaguchi, Hideo Yasunaga

Integrating BRAFV600E mutation, ultrasonic and clinicopathologic characteristics for predicting the risk of cervical central lymph node metastasis in papillary thyroid carcinoma

• Open Access
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Zheng Zhang, Xin Zhang, Yifei Yin, Shuangshuang Zhao, Keke Wang, Mengyuan Shang, Baoding Chen, Xincai Wu

Rationale and design of a prospective, multicenter, phase II clinical trial of safety and efficacy evaluation of long course neoadjuvant chemoradiotherapy plus tislelizumab followed by total mesorectal excision for locally advanced rectal cancer (NCRT-PD1-LARC trial)

• Open Access
• Study protocol

Zhengyang Yang, Xiao Zhang, Jie Zhang, Jiale Gao, Zhigang Bai, Wei Deng, Guangyong Chen, Yongbo An, Yishan Liu, Qi Wei, Jiagang Han, Ang Li, Gang Liu, Yi Sun, Dalu Kong, Hongwei Yao, Zhongtao Zhang

The identification of liver metastasis- and prognosis-associated genes in pancreatic ductal adenocarcinoma

• Open Access
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Hong Luan, Ye He, Tuo Zhang, Yanna Su, Liping Zhou

Increased use of diagnostic CT imaging increases the detection of stage IA lung cancer: pathways and patient characteristics

• Open Access
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Charlotte Hyldgaard, Christian Trolle, Stefan Markus Walbom Harders, Henriette Engberg, Torben Riis Rasmussen, Henrik Møller

AQP9 and ZAP70 as immune-related prognostic biomarkers suppress proliferation, migration and invasion of laryngeal cancer cells

• Open Access
• Research

Li Ren, Ping Li, Zhouping Li, Quan Chen

Prognostic biomarker SGSM1 and its correlation with immune infiltration in gliomas

• Open Access
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Junsheng Li, Jia Wang, Yaowei Ding, Jizong Zhao, Wen Wang

Correction: HOXA-AS2 enhances GBM cell malignancy by suppressing miR-2116-3p thereby upregulating SERPINA3

• Open Access
• Correction

Jianrui Sun, Lin Wang

Endoscopic nodal staging in oligometastatic non-small cell lung cancer (NSCLC) being treated with stereotactic ablative radiotherapy (ENDO-SABR)

• Open Access
• Study protocol

Inderdeep Dhaliwal, Shayan Kassirian, Michael A. Mitchell, Mehdi Qiabi, Andrew Warner, Alexander V. Louie, Harvey H. Wong, Christine M. McDonald, Jason Rajchgot, David A. Palma

Prognosis of resected non-small cell lung cancer with pleural plaques on intrathoracic findings

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Atsushi Kagimoto, Takeshi Mimura, Atsushi Kamigaichi, Yoshinori Yamashita

Comprehensive analysis of the associations between clinical factors and outcomes by machine learning, using post marketing surveillance data of cabazitaxel in patients with castration-resistant prostate cancer

• Open Access
• Research

Hirotaka Kazama, Osamu Kawaguchi, Takeshi Seto, Kazuhiro Suzuki, Hideyasu Matsuyama, Nobuaki Matsubara, Yuki Tajima, Taro Fukao

Adapting MultiPLe behavior Interventions that eFfectively Improve (AMPLIFI) cancer survivor health: program project protocols for remote lifestyle intervention and assessment in 3 inter-related randomized controlled trials among survivors of obesity-related cancers

• Open Access
• Study protocol

Dori Pekmezi, Kevin Fontaine, Laura Q. Rogers, Maria Pisu, Michelle Y. Martin, Yu-Mei Schoenberger-Godwin, Robert A. Oster, Kelly Kenzik, Nataliya V. Ivankova, Wendy Demark-Wahnefried

Routes to cancer diagnosis for patients with pre-existing psychiatric disorders: a nationwide register-based cohort study

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• Research

Line Flytkjær Virgilsen, Peter Vedsted, Alina Zalounina Falborg, Anette Fischer Pedersen, Anders Prior, Henry Jensen

Evaluation of CSTB and DMBT1 expression in saliva of gastric cancer patients and controls

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• Research

Maryam Koopaie, Marjan Ghafourian, Soheila Manifar, Shima Younespour, Mansour Davoudi, Sajad Kolahdooz, Mohammad Shirkhoda

LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway

• Open Access
• Research

Yuen Tan, Qingchuan Chen, Siwei Pan, Wen An, Huimian Xu, Yao Xing, Jianjun Zhang

Understanding the lived experience of lung cancer: a European social media listening study

• Open Access
• Research

Ana Rodrigues, Jyoti Chauhan, Alexandros Sagkriotis, Sathyaraj Aasaithambi, Michele Montrone

Machine learning algorithms to estimate 10-Year survival in patients with bone metastases due to prostate cancer: toward a disease-specific survival estimation tool

• Open Access
• Research

Ashley B. Anderson, Clare Grazal, Rikard Wedin, Claire Kuo, Yongmei Chen, Bryce R. Christensen, Jennifer Cullen, Jonathan A. Forsberg

Dynamic trajectory of platelet counts after the first cycle of induction chemotherapy in AML patients

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• Research

Yazhen Bi, Zhaohui Wang, Saran Feng, Yan Wang, Yang Zhao, Hong Li, Jingyi Yu, Qian Liu, Chuansheng Zhu, Mingzhuo Li

Dual targeting of FGFR3 and ERBB3 enhances the efficacy of FGFR inhibitors in FGFR3 fusion-driven bladder cancer

• Open Access
• Research

Andrew J. Weickhardt, David K. Lau, Margeaux Hodgson-Garms, Austen Lavis, Laura J. Jenkins, Natalia Vukelic, Paul Ioannidis, Ian Y. Luk, John M. Mariadason

Evolution of patterns of care for women with cervical cancer in Morocco over a decade

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Abdellatif Benider, Karima Bendahhou, Catherine Sauvaget, Hind Mrabti, Farida Selmouni, Richard Muwonge, Leila Alaoui, Eric Lucas, Youssef Chami, Loubna Abousselham, Maria Bennani, Hassan Errihani, Rengaswamy Sankaranarayanan, Rachid Bekkali, Partha Basu

Correction: Protein-based prognostic signature for predicting the survival and immunotherapeutic efficiency of endometrial carcinoma

• Open Access
• Correction

Jinzhi Lai, Tianwen Xu, Hainan Yang

Circulating lnc-LOC as a novel noninvasive biomarker in the treatment surveillance of acute promyelocytic leukaemia

• Open Access
• Research

Guiran Wang, Guiling Yan, Kanru Sang, Huijie Yang, Ni Sun, Yuanyuan Bai, Feng Xu, Xiaoqun Zheng, Zhanguo Chen

Androgen Deprivation therapy for Oligo-recurrent Prostate cancer in addition to radioTherapy (ADOPT): study protocol for a randomised phase III trial

• Open Access
• Study protocol

J. Janssen, F. H. E. Staal, C. L. Brouwer, J. A. Langendijk, I. J. de Jong, R. J. A. van Moorselaar, E. Schuit, J. F. Verzijlbergen, R. J. Smeenk, S. Aluwini

Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol

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• Study protocol

Linea Natalie Toksvang, Bodil Als-Nielsen, Christopher Bacon, Ruta Bertasiute, Ximo Duarte, Gabriele Escherich, Elín Anna Helgadottir, Inga Rinvoll Johannsdottir, Ólafur G. Jónsson, Piotr Kozlowski, Cecilia Langenskjöld, Kristi Lepik, Riitta Niinimäki, Ulrik Malthe Overgaard, Mari Punab, Riikka Räty, Heidi Segers, Inge van der Sluis, Owen Patrick Smith, Marion Strullu, Goda Vaitkevičienė, Hilde Skuterud Wik, Mats Heyman, Kjeld Schmiegelow

A protocol to clinically evaluate liquid biopsies as a tool to speed up diagnosis of children and young adults with aggressive infection-related lymphoma in East Africa “(AI-REAL)”

• Open Access
• Study protocol

Ismail D. Legason, Martin D. Ogwang, Clara Chamba, Elifuraha Mkwizu, Claire El Mouden, Hadija Mwinula, Lulu Chirande, Anna Schuh, Faraja Chiwanga

Correction to: SNCA correlates with immune infiltration and serves as a prognostic biomarker in lung adenocarcinoma

• Open Access
• Correction

Xiuao Zhang, Zhengcun Wu, Kaili Ma

Clinical impact of primary tumor sidedness and sex on unresectable post-recurrence survival in resected pathological stage II-III colorectal cancers: a nationwide multicenter retrospective study

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• Research

Shinya Abe, Kazushige Kawai, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Tsuyoshi Ozawa, Yuichiro Yokoyama, Yuzo Nagai, Hiroyuki Anzai, Hirofumi Sonoda, Shinichi Yamauchi, Kenichi Sugihara, Soichiro Ishihara

High MICAL-L2 expression and its role in the prognosis of colon adenocarcinoma

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Yixing Yang, Fengwen Ye, Tianxiang Xia, Qianwen Wang, Yujie Zhang, Jun Du

DNA methylation of miR-138 regulates cell proliferation and EMT in cervical cancer by targeting EZH2

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Rui Chen, Qiyu Gan, Shuting Zhao, Dongrui Zhang, Shunli Wang, Lili Yao, Min Yuan, Jingxin Cheng

Establishment of patient-derived organoids and a characterization-based drug discovery platform for treatment of pancreatic cancer

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Sadanori Watanabe, Akitada Yogo, Tsuguteru Otsubo, Hiroki Umehara, Jun Oishi, Toru Kodo, Toshihiko Masui, Shigeo Takaishi, Hiroshi Seno, Shinji Uemoto, Etsuro Hatano

Associations of keratinocyte cancers with snp variants in the sonic hedgehog pathway

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Astrid J. Rodriguez-Acevedo, Annika Antonsson, Upekha E. Liyanage, Maria Celia Hughes, Scott Gordon, Jolieke van der Pols, Adele C. Green

The relationship between medication literacy and skin adverse reactions in non-small-cell lung cancer patients undergoing targeted EGFR-TKI therapy

• Open Access
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Ruofei Du, Huashan Yang, Huiyue Zhou, Lixia Ma, Mikiyas Amare Getu, Changying Chen, Tao Wang

Postoperative radiotherapy for meningiomas – a decision-making analysis

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Galina Farina Fischer, Detlef Brügge, Nicolaus Andratschke, Brigitta Gertrud Baumert, Davide Giovanni Bosetti, Francesca Caparrotti, Evelyn Herrmann, Alexandros Papachristofilou, Susanne Rogers, Lucia Schwyzer, Daniel Rudolf Zwahlen, Thomas Hundsberger, Paul Martin Putora

Digital phenotyping in young breast cancer patients treated with neoadjuvant chemotherapy (the NeoFit Trial): protocol for a national, multicenter single-arm trial

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Lidia Delrieu, Anne-Sophie Hamy, Florence Coussy, Amyn Kassara, Bernard Asselain, Juliana Antero, Paul De Villèle, Elise Dumas, Nicolas Forstmann, Julien Guérin, Judicael Hotton, Christelle Jouannaud, Maud Milder, Armand Leopold, Adrien Sedeaud, Pauline Soibinet, Jean-François Toussaint, Vincent Vercamer, Enora Laas, Fabien Reyal

Leveraging artificial intelligence to predict ERG gene fusion status in prostate cancer

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• Research article

Vipulkumar Dadhania, Daniel Gonzalez, Mustafa Yousif, Jerome Cheng, Todd M. Morgan, Daniel E. Spratt, Zachery R. Reichert, Rahul Mannan, Xiaoming Wang, Anya Chinnaiyan, Xuhong Cao, Saravana M. Dhanasekaran, Arul M. Chinnaiyan, Liron Pantanowitz, Rohit Mehra

Reflecting on the utility of standardized uptake values on 18F-FDG PET in nasopharyngeal carcinoma

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Xiufang Qiu, Haixia Wu, Ting Xu, Shihan Xie, Ziqing You, Yixin Hu, Yinghong Zheng, Zewei Liang, Chaoxiong Huang, Li Yi, Li Li, Jing Liu, Zhaodong Fei, Chuanben Chen

Identification of immune infiltration-related genes as prognostic indicators for hepatocellular carcinoma

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Kunfu Dai, Chao Liu, Ge Guan, Jinzhen Cai, Liqun Wu

Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer

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• Research

Evan B. Glass, Alyssa A. Hoover, Kennady K. Bullock, Matthew Z. Madden, Bradley I. Reinfeld, Whitney Harris, Dominique Parker, Demetra H. Hufnagel, Marta A. Crispens, Dineo Khabele, W. Kimryn Rathmell, Jeffrey C. Rathmell, Andrew J. Wilson, Todd D. Giorgio, Fiona E. Yull

The oncogenic role of tubulin alpha-1c chain in human tumours

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Xinyao Hu, Hua Zhu, Biao Chen, Xiaoqin He, Yang Shen, Xiaoyu Zhang, Yangtao Xu, Ximing Xu

The identification of miRNA and mRNA expression profiles associated with pediatric atypical teratoid/rhabdoid tumor

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Xinke Xu, Hongyao Yuan, Junping Pan, Wei Chen, Cheng Chen, Yang Li, Fangcheng Li

Cost-effectiveness of using artificial intelligence versus polygenic risk score to guide breast cancer screening

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Shweta Mital, Hai V. Nguyen

Long-term outcome and relapse patterns in Ewing sarcoma patients with extensive lung/pleural metastases after a complete response to systemic therapy

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• Research

Jie Xu, Xin Zhi, Lu Xie, Xin Sun, Xingyu Liu, Kuisheng Liu, Wei Guo

A real-world retrospective study of the use of Ki-67 testing and treatment patterns in patients with HR+, HER2− early breast cancer in the United States

• Open Access
• Research article

Jacqueline Brown, Savannah Scardo, Michael Method, Dan Schlauch, Amanda Misch, Shaita Picard, Erika Hamilton, Suzanne Jones, Howard Burris, David Spigel

A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study

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• Research article

Kazuki Takada, Mototsugu Shimokawa, Shinkichi Takamori, Shinichiro Shimamatsu, Fumihiko Hirai, Tetsuzo Tagawa, Tatsuro Okamoto, Motoharu Hamatake, Yuko Tsuchiya-Kawano, Kohei Otsubo, Koji Inoue, Yasuto Yoneshima, Kentaro Tanaka, Isamu Okamoto, Yoichi Nakanishi, Masaki Mori

The prognostic value of weight loss during radiotherapy among patients with nasopharyngeal carcinoma: a large-scale cohort study

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• Research article

Ya-Nan Jin, Tian-Liang Xia, Dong-Mei Mai, Ji-Jin Yao, Chang Jiang, Wen-Zhuo He, Liang-Ping Xia

Image-guided navigation for locally advanced primary and locally recurrent rectal cancer: evaluation of its early cost-effectiveness

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• Research article

Melanie Lindenberg, Astrid Kramer, Esther Kok, Valesca Retèl, Geerard Beets, Theo Ruers, Wim van Harten

Three-arm phase II trial comparing camrelizumab plus chemotherapy versus camrelizumab plus chemoradiation versus chemoradiation as preoperative treatment for locally advanced esophageal squamous cell carcinoma (NICE-2 Study)

• Open Access
• Study protocol

Yang Yang, Li Zhu, Yan Cheng, Zhichao Liu, Xiaoyue Cai, Jinchen Shao, Ming Zhang, Jun Liu, Yifeng Sun, Yin Li, Jun Yi, Bentong Yu, Hongjing Jiang, Hezhong Chen, Hong Yang, Lijie Tan, Zhigang Li

Study protocol comparing the ethical, psychological and socio-economic impact of personalised breast cancer screening to that of standard screening in the “My Personal Breast Screening” (MyPeBS) randomised clinical trial

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• Study protocol

Alexandra Roux, Rachel Cholerton, Jonathan Sicsic, Nora Moumjid, David P. French, Paolo Giorgi Rossi, Corinne Balleyguier, Michal Guindy, Fiona J. Gilbert, Jean-Benoit Burrion, Xavier Castells, David Ritchie, Debbie Keatley, Camille Baron, Suzette Delaloge, Sandrine de Montgolfier

Maintenance Therapy with Aromatase Inhibitor in epithelial Ovarian Cancer (MATAO): study protocol of a randomized double-blinded placebo-controlled multi-center phase III Trial

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• Study protocol

Pamela M. J. McLaughlin, Maximilian Klar, Tibor A. Zwimpfer, Gilles Dutilh, Marcus Vetter, Christian Marth, Andreas du Bois, Carmen Schade-Brittinger, Alexander Reuss, Claudine Bommer, Christian Kurzeder, Viola Heinzelmann-Schwarz

Gestational trophoblastic neoplasia with extrauterine metastasis but lacked uterine primary lesions: a single center experience and literature review

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Jingnan Li, Yu Wang, Bingjian Lu, Weiguo Lu, Xing Xie, Yuanming Shen

A novel and sensitive DNA methylation marker for the urine-based liquid biopsies to detect bladder cancer

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Leihong Deng, Haichao Chao, Huanhuan Deng, Zhaojun Yu, Rongsong Zhao, Longwu Huang, Yun Gong, Yueting Zhu, Qingping Wang, Feng Li, Lirong Liu, Lei He, Zhimin Tang, Caizhi Liao, Yan Qi, Xianshu Wang, Tao Zeng, Hongzhi Zou

A multicenter, dose-finding, phase 1b study of imatinib in combination with alpelisib as third-line treatment in patients with advanced gastrointestinal stromal tumor

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Maria A. Pantaleo, Michael C. Heinrich, Antoine Italiano, Claudia Valverde, Patrick Schöffski, Giovanni Grignani, Anna K. L. Reyners, Sebastian Bauer, Peter Reichardt, Daniel Stark, Ghimja Berhanu, Ulrike Brandt, Tommaso Stefanelli, Hans Gelderblom

Pharmacogenomics of in vitro response of the NCI-60 cancer cell line panel to Indian natural products

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Hari Sankaran, Simarjeet Negi, Lisa M. McShane, Yingdong Zhao, Julia Krushkal

Combined chemoradiotherapy showed improved outcome with early-stage HPV-positive oropharyngeal cancers

• Open Access
• Research

X. J. David Lu, Emmanuel Jackson, Jason Chew, Sally Nguyen, Jonn Wu, Catherine F. Poh, Eitan Prisman

Efficacy of first-line treatments in the elderly and non-elderly patients with advanced epidermal growth factor receptor mutated, non-small cell lung cancer: a network meta-analysis

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Ziyi Xu, Chengcheng Liu, Yixiang Zhu, Zihua Zou, Tongji Xie, Puyuan Xing, Le Wang, Junling Li

Decision making for anti-VEGF inhibitor continuation: dip stick? or urine protein/creatinine ratio? (VERSiON UP study)

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Michio Nakamura, Taro Funakoshi, Shigeki Kataoka, Takahiro Horimatsu, Yoshitaka Nishikawa, Takeshi Matsubara, Takuro Mizukami, Tomoyuki Goto, Kenji Tsuchihashi, Eishi Baba, Takehiko Tsumura, Yoshiaki Mihara, Tetsuya Hamaguchi, Motoko Yanagita, Manabu Muto

Proton pump inhibitors may reduce the efficacy of ribociclib and palbociclib in metastatic breast cancer patients based on an observational study

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Kadir Eser, Arif Hakan Önder, Emel Sezer, Timuçin Çil, Ali İnal, Banu Öztürk, Vehbi Erçolak, Berna Bozkurt Duman, Halil Çelik, Tolga Köşeci, Oğuzhan Kesen

A prospective observational cohort study of lenvatinib as initial treatment in patients with BCLC-defined stage B hepatocellular carcinoma

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Satoshi Kobayashi, Taito Fukushima, Makoto Ueno, Satoshi Moriya, Makoto Chuma, Kazushi Numata, Kota Tsuruya, Shunji Hirose, Tatehiro Kagawa, Nobuhiro Hattori, Tsunamasa Watanabe, Kotaro Matsunaga, Michihiro Suzuki, Haruki Uojima, Hisashi Hidaka, Chika Kusano, Motoko Suzuki, Manabu Morimoto

Association of CTLA-4 and IL-4 polymorphisms in viral induced liver cancer

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Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Janeen H. Trembley, Areeb Rizwan, Fatima Faraz, Syeda Alveena Shah, Mahrukh Farooqi, Naeem Mahmood Ashraf, Tayyaba Afsar, Ali Almajwal, Nawaf W. Alruwaili, Suhail Razak

Influence of cytochrome P450 and glutathione S transferase polymorphisms on response to nilotinib therapy among chronic myeloidleukemia patients from Pakistan

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• Research article

Samina Naz Mukry, Aneeta Shahni, Uzma Zaidi, Tahir Sultan Shamsi

Effects of intensive physiotherapy on Quality of Life (QoL) after pancreatic cancer resection: a randomized controlled trial

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Dirk Weyhe, Dennis Obonyo, Verena Uslar, Navid Tabriz

Cytotoxic effect of disulfiram/copper on human cervical cancer cell lines and LGR5-positive cancer stem-like cells

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• Research

Hao-Zhe Cao, Wen-Ting Yang, Peng-Sheng Zheng

A population survey on beliefs around cervical cancer screening: determining the barriers and facilitators associated with attendance

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• Research

Gaby Judah, Faisal Dilib, Ara Darzi, Sarah Huf

RUNX1 is a promising prognostic biomarker and related to immune infiltrates of cancer-associated fibroblasts in human cancers

• Open Access
• Research

Zhouting Tuo, Ying Zhang, Xin Wang, Shuxin Dai, Kun Liu, Dian Xia, Jinyou Wang, Liangkuan Bi

Development and validation of a radiomics-based nomogram for the preoperative prediction of microsatellite instability in colorectal cancer

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• Research

Mingliang Ying, Jiangfeng Pan, Guanghong Lu, Shaobin Zhou, Jianfei Fu, Qinghua Wang, Lixia Wang, Bin Hu, Yuguo Wei, Junkang Shen

PAFAH1B3 predicts poor prognosis and promotes progression in lung adenocarcinoma

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Suping Tang, Jun Ni, Bohua Chen, Fei Sun, Jinbo Huang, Songshi Ni, Zhiyuan Tang

Low level of Fibrillarin, a ribosome biogenesis factor, is a new independent marker of poor outcome in breast cancer

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Flora Nguyen Van Long, Audrey Lardy-Cleaud, Dimitri Carène, Caroline Rossoni, Frédéric Catez, Paul Rollet, Nathalie Pion, Déborah Monchiet, Agathe Dolbeau, Marjorie Martin, Valentin Simioni, Susan Bray, Doris Le Beherec, Fernanda Mosele, Ibrahim Bouakka, Amélie Colombe-Vermorel, Laetitia Odeyer, Alexandra Diot, Lee B. Jordan, Alastair M. Thompson, Françoise Jamen, Thierry Dubois, Sylvie Chabaud, Stefan Michiels, Isabelle Treilleux, Jean-Christophe Bourdon, David Pérol, Alain Puisieux, Fabrice André, Jean-Jacques Diaz, Virginie Marcel

Burden of cancers in India - estimates of cancer crude incidence, YLLs, YLDs and DALYs for 2021 and 2025 based on National Cancer Registry Program

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Vaitheeswaran Kulothungan, Krishnan Sathishkumar, Sravya Leburu, Thilagavathi Ramamoorthy, Santhappan Stephen, Dharmappa Basavarajappa, Nifty Tomy, Rohith Mohan, Geetha R. Menon, Prashant Mathur

Safety and effectiveness of eribulin in Japanese patients with soft tissue sarcoma including rare subtypes: a post-marketing observational study

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Akira Kawai, Hiroyuki Narahara, Shunji Takahashi, Tomoki Nakamura, Hiroshi Kobayashi, Yasunori Megumi, Toshiyuki Matsuoka, Eisuke Kobayashi

Prognostic value of CD4+ T lymphopenia in non-small cell lung Cancer

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Guillaume Eberst, Dewi Vernerey, Caroline Laheurte, Aurélia Meurisse, Vincent Kaulek, Laurie Cuche, Pascale Jacoulet, Hamadi Almotlak, Jean Lahourcade, Marie Gainet-Brun, Elizabeth Fabre, Françoise Le Pimpec-Barthes, Olivier Adotevi, Virginie Westeel

Overexpression of angiogenic factors and matrix metalloproteinases in the saliva of oral squamous cell carcinoma patients: potential non-invasive diagnostic and therapeutic biomarkers

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• Research

Meijuan Cai, Zhichao Zheng, Zhibao Bai, Kexiong Ouyang, Qiuyu Wu, Shaofen Xu, Lihuan Huang, Yingtong Jiang, Lijing Wang, Jie Gao, Janak L. Pathak, Lihong Wu

Factors that contribute to disparities in time to acute leukemia diagnosis in young people: an in depth qualitative interview study

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Lucky Ding, Julia E. Szymczak, Erica Evans, Emma Canepa, Ashley E. Martin, Farah Contractor, Richard Aplenc, Galen Joseph, Lena E. Winestone

Utilization of radiation therapy and predictors of noncompliance among Syrian refugees in Turkey

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• Research article

Mutlay Sayan, Mehmet Fuat Eren, Sarah Sabrine Kilic, Ayse Kotek, Sedenay Oskeroglu Kaplan, Ozge Duran, Funda Cukurcayır, Ibrahim Babalıoglu, Ozlem Derinalp Or, Gul Aysen Ozturk, Celalettin Eroglu, Fatma Teke, Neslihan Kurtul, Tugce Kutuk, Beyhan Ceylaner Bicakci, Sukran Senyurek, Meryem Aktan, Swati Mamidanna, Nisha Ohri, Bruce Haffty, Banu Atalar

Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study

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Xiaoqi Zeng, Shanshan Jiang, Simin Ruan, Lijun Zhu, Huining Lian, Minfeng Liu, Zhaoze Guo, Jingyun Guo, Changsheng Ye, Yunjiu Cheng, Jianyu Dong

miR-107 is involved in the regulation of NEDD9-mediated invasion and metastasis in breast cancer

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• Research article

Jiamin Zhou, Xianglin Sun, Xinyu Zhang, Huan Yang, Zhenglin Jiang, Qianqian Luo, Yifei Liu, Guohua Wang

Level IV neck dissection in cN0 HPV-negative oropharyngeal squamous cell carcinoma: a retrospective cohort study

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• Research article

Zirong Huo, Shuiting Fu, Chunyue Ma, Surui Sheng

GECOP-MMC: phase IV randomized clinical trial to evaluate the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) with mytomicin-C after complete surgical cytoreduction in patients with colon cancer peritoneal metastases

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• Study protocol

Fernando Pereira, Angel Serrano, Israel Manzanedo, Estibalitz Pérez-Viejo, Santiago González-Moreno, Luis González-Bayón, Alvaro Arjona-Sánchez, Juan Torres, Isabel Ramos, Maria E. Barrios, Pedro Cascales, Rafael Morales, Enrique Boldó, Alfonso García-Fadrique, Xabier Arteaga, Alberto Gutierrez-Calvo, Susana Sánchez-García, Enrique Asensio, Cesar P. Ramírez, Manuel Artiles, Javier Vaqué, Pedro A. Parra, Pedro Villarejo, Cristóbal Muñoz-Casares, Estrella Turienzo, Alicia Calero, Isabel Jaén Torrejimeno, Isabel Prieto, Julio Galindo, Vicente Borrego, Manuel E. Marcello, Cristina Rihuete, Joaquin Carrasco, Luis Gomez-Quiles

Neoadjuvant irradiation of extremity soft tissue sarcoma with ions (Extrem-ion): study protocol for a randomized phase II pilot trial

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• Study protocol

D. Brügemann, B. Lehner, M. Kieser, J. Krisam, A. Hommertgen, C. Jaekel, S. B. Harrabi, K. Herfarth, G. Mechtesheimer, O. Sedlaczek, G. Egerer, A. Geisbüsch, M. Uhl, J. Debus, K. Seidensaal

Perioperative treatment in resectable gastric cancer with spartalizumab in combination with fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT): a phase II study (GASPAR)

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• Study protocol

Mélanie Dos Santos, Justine Lequesne, Alexandra Leconte, Stéphane Corbinais, Aurélie Parzy, Jean-Marc Guilloit, Sharmini Varatharajah, Pierre-Emmanuel Brachet, Marine Dorbeau, Dominique Vaur, Louis-Bastien Weiswald, Laurent Poulain, Corentin Le Gallic, Marie Castera-Tellier, Marie-Pierre Galais, Bénédicte Clarisse

Randomized single-blind comparative study of the midazolam/pethidine combination and midazolam alone during bronchoscopy

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Masahiro Katsurada, Motoko Tachihara, Naoko Katsurada, Naoya Takata, Hiroki Sato, Chihiro Mimura, Junya Yoshioka, Koichi Furukawa, Masako Yumura, Takehiro Otoshi, Yuichiro Yasuda, Tatsunori Kiriu, Daisuke Hazama, Tatsuya Nagano, Masatsugu Yamamoto, Yoshihiro Nishimura, Kazuyuki Kobayashi

Impact of geriatric nutritional risk index on outcomes after gastrectomy in elderly patients with gastric cancer: a retrospective multicenter study in Japan

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Tomoyuki Matsunaga, Hiroaki Saito, Tomohiro Osaki, Sadamu Takahashi, Akemi Iwamoto, Kenji Fukuda, Kenjiro Taniguchi, Hirohiko Kuroda, Tsutomu Takeuchi, Kenji Sugamura, Kenichi Sumi, Kuniyuki Katano, Yuji Shishido, Kozo Miyatani, Yoshiyuki Fujiwara

Is lobectomy superior to sub-lobectomy in non-small cell lung cancer with pleural invasion? A population-based competing risk analysis

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Xue Song, Yangyang Xie, Yurou Zhu, Yafang Lou

Identification and validation of TNFRSF4 as a high-profile biomarker for prognosis and immunomodulation in endometrial carcinoma

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Heng Ma, Peng-hui Feng, Shuang-ni Yu, Zhao-hui Lu, Qi Yu, Jie Chen

Safety and efficacy of pegylated recombinant human granulocyte colony-stimulating factor during concurrent chemoradiotherapy for small-cell lung cancer: a retrospective, cohort-controlled trial

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Cunliang Wang, Shouhui Zhu, Chuanwang Miao, Yu Wang, Jiazhen Chen, Shuanghu Yuan, Xudong Hu

Factors associated with serum CA125 level in women without ovarian cancer in the United States: a population-based study

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Xiao Hu, Jingzhou Zhang, Yu Cao

An immune-related lncRNA pairs signature to identify the prognosis and predict the immune landscape of laryngeal squamous cell carcinoma

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Lvsheng Qian, Tingting Ni, Bing Fei, Hui Sun, Haosheng Ni

Impact of cumulative body mass index and cardiometabolic diseases on survival among patients with colorectal and breast cancer: a multi-centre cohort study

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Mirjam Kohls, Heinz Freisling, Hadrien Charvat, Isabelle Soerjomataram, Vivian Viallon, Veronica Davila-Batista, Rudolf Kaaks, Renée Turzanski-Fortner, Krasimira Aleksandrova, Matthias B. Schulze, Christina C. Dahm, Helene Tilma Vistisen, Agnetha Linn Rostgaard-Hansen, Anne Tjønneland, Catalina Bonet, Maria-Jose Sánchez, Sandra Colorado-Yohar, Giovanna Masala, Domenico Palli, Vittorio Krogh, Fulvio Ricceri, Olov Rolandsson, Sai San Moon Lu, Konstantinos K. Tsilidis, Elisabete Weiderpass, Marc J. Gunter, Pietro Ferrari, Ursula Berger, Melina Arnold

A comprehensive evaluation of potentially significant drug-drug, drug-herb, and drug-food interactions among cancer patients receiving anticancer drugs

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Amer A. Koni, Maisa A. Nazzal, Bushra A. Suwan, Samah S. Sobuh, Najiya T. Abuhazeem, Asil N. Salman, Husam T. Salameh, Riad Amer, Sa’ed H. Zyoud

Prognostic significance of different molecular typing methods and immune status based on RNA sequencing in HR-positive and HER2-negative early-stage breast cancer

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Xinyu Ren, Yu Song, Yanna zhang, Huanwen Wu, Longyun Chen, Junyi Pang, Liangrui Zhou, Songjie Shen, Zhiyong Liang

RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma

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Cheng Lin, Meifang Li, Na Lin, Jingfeng Zong, Jianji Pan, Yunbin Ye

Homologous recombination deficiency in diverse cancer types and its correlation with platinum chemotherapy efficiency in ovarian cancer

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Hao Wen, Zheng Feng, Yutong Ma, Rui Liu, Qiuxiang Ou, Qinhao Guo, Yi Shen, Xue Wu, Yang Shao, Hua Bao, Xiaohua Wu

Risk factors for pneumonitis in advanced extrapulmonary cancer patients treated with immune checkpoint inhibitors

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Yasuki Uchida, Daisuke Kinose, Yukihiro Nagatani, Sachiko Tanaka-Mizuno, Hiroaki Nakagawa, Kentaro Fukunaga, Masafumi Yamaguchi, Yasutaka Nakano

SCARA3 inhibits cell proliferation and EMT through AKT signaling pathway in lung cancer

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Jeeho Kim, Ho Jin You, Chakyung Youn

Feasibility and thematic analysis of narrative visualization materials with physical activity monitoring among breast cancer survivors

• Open Access
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Jason R. Bentley, Xiaoying Yu, Amol M. Karmarkar, Brian Downer, John Prochaska, Elizabeth J. Lyons

Direct bone marrow injection of human bone marrow-derived stromal cells into mouse femurs results in greater prostate cancer PC-3 cell proliferation, but not specifically proliferation within the injected femurs

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Bianca Nowlan, Elizabeth D. Williams, Michael Robert Doran

Identification of spatio-temporal clusters of lung cancer cases in Pennsylvania, USA: 2010–2017

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Nuria Camiña, Tara L. McWilliams, Thomas P. McKeon, Trevor M. Penning, Wei-Ting Hwang

MTHFD2 is a potential oncogene for its strong association with poor prognosis and high level of immune infiltrates in urothelial carcinomas of bladder

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Lin Zhu, Xianhui Liu, Weiyu Zhang, Hao Hu, Qi Wang, Kexin Xu

PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment

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Sarah Johnson, Yaroslava Karpova, Danping Guo, Atreyi Ghatak, Dmitriy A. Markov, Alexei V. Tulin

Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development

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Nan Hao, Daming Yang, Tianpei Liu, Shucheng Liu, Xinsheng Lu, Libo Chen

Pioglitazone and breast cancer risk in female patients with type 2 diabetes mellitus: a retrospective cohort analysis

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Chin-Hsiao Tseng

Identifying and handling unbalanced baseline characteristics in a non-randomized, controlled, multicenter social care nurse intervention study for patients in advanced stages of cancer

• Open Access
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Johann Frick, Pimrapat Gebert, Ulrike Grittner, Anne Letsch, Daniel Schindel, Liane Schenk

DAB2IP down-regulates HSP90AA1 to inhibit the malignant biological behaviors of colorectal cancer

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Mengna Zhang, Yanan Peng, Zhenwei Yang, Hailin Zhang, Cong Xu, Lan Liu, Qiu Zhao, Jixiong Wu, Hongling Wang, Jing Liu

KDM3A-mediated SP1 activates PFKFB4 transcription to promote aerobic glycolysis in osteosarcoma and augment tumor development

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Wei Wang, Bin Wang

Health-related quality of life scores of metastatic pancreatic cancer patients responsive to first line chemotherapy compared to newly derived EORTC QLQ-C30 reference values

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Suvina Amin, Seongjung Joo, Sandra Nolte, Hyun Kyoo Yoo, Nikunj Patel, Hilary F. Byrnes, Sara Costa-Cabral, Colin D. Johnson

Overexpressed p-S6 associates with lymph node metastasis and predicts poor prognosis in non-small cell lung cancer

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Yaoxiang Tang, Jiadi Luo, Ying Zhou, Hongjing Zang, Yang Yang, Sile Liu, Hongmei Zheng, Jian Ma, Songqing Fan, Qiuyuan Wen

Safety, activity, and pharmacokinetics of camrelizumab in advanced Asian melanoma patients: a phase I study

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Li Zhou, Xiaowen Wu, Zhihong Chi, Lu Si, Xinan Sheng, Yan Kong, Lili Mao, Bin Lian, Bixia Tang, Xieqiao Yan, Xuan Wang, Xue Bai, Siming Li, Xiaoting Wei, Juan Li, Qing Yang, Jun Guo, Chuanliang Cui

Berberine inhibits intestinal carcinogenesis by suppressing intestinal pro-inflammatory genes and oncogenic factors through modulating gut microbiota

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Haitao Chen, Chenxiao Ye, Biyu Cai, Fan Zhang, Xuanying Wang, Jin Zhang, Zewei Zhang, Yong Guo, Qinghua Yao

Mir-675-5p supports hypoxia-induced drug resistance in colorectal cancer cells

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Chiara Zichittella, Maria Magdalena Barreca, Aurora Cordaro, Chiara Corrado, Riccardo Alessandro, Alice Conigliaro

Role of CDH23 as a prognostic biomarker and its relationship with immune infiltration in acute myeloid leukemia

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Jiao Yang, Fei Lu, Guangxin Ma, Yihua Pang, Yanan Zhao, Tao Sun, Daoxin Ma, Jingjing Ye, Chunyan Ji

Volasertib as a monotherapy or in combination with azacitidine in patients with myelodysplastic syndrome, chronic myelomonocytic leukemia, or acute myeloid leukemia: summary of three phase I studies

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Uwe Platzbecker, Joerg Chromik, Jan Krönke, Hiroshi Handa, Stephen Strickland, Yasushi Miyazaki, Martin Wermke, Wataru Sakamoto, Yoshifumi Tachibana, Tillmann Taube, Ulrich Germing

Development and technical validation of an ultrasound nebulizer to deliver intraperitoneal pressurized aerosols in a rat colon cancer peritoneal metastases model

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Jonathan R. Buggisch, Daniel Göhler, Julien Sobilo, Stéphanie Lerondel, Günther A. Rezniczek, Michael Stintz, Andreas Rudolph, Nicolas Tabchouri, Sébastien Roger, Mehdi Ouaissi, Urs Giger-Pabst

When to add anti-angiogenesis drugs to EGFR-mutated metastatic non–small cell lung cancer patients: a real-world study from Taiwan

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Chieh-Lung Chen, Sing-Ting Wang, Wei-Chih Liao, Chia-Hung Chen, Chih-Yen Tu, Hung-Jen Chen, Te-Chun Hsia, Wen-Chien Cheng

Construction and validation of a two-gene signature based on SUMOylation regulatory genes in non-small cell lung cancer patients

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Hongxu Sheng, Zhexue Hao, Linhai Zhu, Yuan Zeng, Jianxing He

Extracellular vesicle biomarkers for pancreatic cancer diagnosis: a systematic review and meta-analysis

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Erna Jia, Na Ren, Xianquan Shi, Rongkui Zhang, Haixin Yu, Fan Yu, Shaoyou Qin, Jinru Xue

The pathway and characteristics of patients with non-specific symptoms of cancer: a systematic review

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Ellen Jensen, Jette Kolding Kristensen, Rikke Tveden Bjerglund, Søren Paaske Johnsen, Janus Laust Thomsen

A randomized controlled phase III study comparing hadrontherapy with carbon ions versus conventional radiotherapy – including photon and proton therapy – for the treatment of radioresistant tumors: the ETOILE trial

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• Study protocol

Jacques Balosso, Olivia Febvey-Combes, Annie Iung, Hélène Lozano, Abdoulkader Soumai Alloh, Catherine Cornu, Magali Hervé, Zohra Akkal, Michel Lièvre, Valérie Plattner, Francesca Valvo, Cristina Bono, Maria Rosaria Fiore, Viviana Vitolo, Barbara Vischioni, Stéphanie Patin, Hubert Allemand, François Gueyffier, Jennifer Margier, Pascale Guerre, Sylvie Chabaud, Roberto Orecchia, Pascal Pommier

Efficacy and safety of maintenance immune checkpoint inhibitors with or without pemetrexed in advanced non-squamous non-small cell lung cancer: a retrospective study

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Xiaodong Gu, Zhiyong Shi, Lan Shao, Yuxin Zhang, Yiping Zhang, Zhengbo Song, Wenxian Wang, Guangyuan Lou

Mast cell marker gene signature in head and neck squamous cell carcinoma

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Zhimou Cai, Bingjie Tang, Lin Chen, Wenbin Lei

HMGB1 mediates invasion and PD-L1 expression through RAGE-PI3K/AKT signaling pathway in MDA-MB-231 breast cancer cells

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Kamolporn Amornsupak, Suyanee Thongchot, Chanida Thinyakul, Carol Box, Somaieh Hedayat, Peti Thuwajit, Suzanne A. Eccles, Chanitra Thuwajit

Extended lower paratracheal lymph node resection during esophagectomy for cancer – safety and necessity

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C. Mann, F. Berlth, E. Hadzijusufovic, E. Tagkalos, E. Uzun, C. Codony, H. Lang, P. P. Grimminger

Gene alternation of cerebrospinal fluid in patients with leptomeningeal metastases of lung adenocarcinoma using next-generation sequencing

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Hainan Yang, Lei Wen, Yingying Pan, Changguo Shan, Weiping Hong, Hui Wang, Cheng Zhou, Linbo Cai, Caicun Zhou

TP73-AS1 as a predictor of clinicopathological parameters and prognosis in human malignancies: a meta and bioinformatics analysis

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Caizhi Chen, Jingjing Wang, Yeqian Feng, Ye Liang, Yan Huang, Wen Zou

Cancer incidence and mortality and risk factors in member countries of the " Belt and Road " initiative

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Baohua Wang, Fengdie He, Yanan Hu, Qiutong Wang, Dan Wang, Yuting Sha, Jing Wu

Enhancement of the International prognostic index with β2-microglobulin, platelet count and red blood cell distribution width: a new prognostic model for diffuse large B-cell lymphoma in the rituximab era

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Haizhu Chen, Qiaofeng Zhong, Yu Zhou, Yan Qin, Jianliang Yang, Peng Liu, Xiaohui He, Shengyu Zhou, Changgong Zhang, Lin Gui, Sheng Yang, Liqiang Zhou, Yuankai Shi

Clinical significance and correlation of PD-L1, B7-H3, B7-H4, and TILs in pancreatic cancer

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Jiayue Yang, Zhen Tian, Han Gao, Fan Xiong, Cuiping Cao, Jiaojiao Yu, Wei Shi, Qiang Zhan, Cheng Yang

Risk assessment and prediction for lung cancer among Hong Kong Chinese men

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Lap Ah Tse, Feng Wang, Martin Chi-sang Wong, Joseph Siu-kei Au, Ignatius Tak-sun Yu

Impact of clinical and molecular features on efficacy and outcome of patients with non-small cell lung cancer receiving second-line osimertinib

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Ying Jin, Chen Lin, Xun Shi, Qiong He, Junrong Yan, Xinmin Yu, Ming Chen

Validation of genomic and transcriptomic models of homologous recombination deficiency in a real-world pan-cancer cohort

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Benjamin D. Leibowitz, Bonnie V. Dougherty, Joshua S. K. Bell, Joshuah Kapilivsky, Jackson Michuda, Andrew J. Sedgewick, Wesley A. Munson, Tushar A. Chandra, Jonathan R. Dry, Nike Beaubier, Catherine Igartua, Timothy Taxter

Optimal surveillance of intraductal papillary mucinous neoplasms of the pancreas focusing on remnant pancreas recurrence after surgical resection

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Tomokazu Fuji, Yuzo Umeda, Kosei Takagi, Ryuichi Yoshida, Kazuhiro Yoshida, Kazuya Yasui, Kazuyuki Matsumoto, Hironari Kato, Takahito Yagi, Toshiyoshi Fujiwara

Cystatin SN promotes epithelial-mesenchymal transition and serves as a prognostic biomarker in lung adenocarcinoma

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Jian Yang, Gaomeng Luo, Chang Li, Zhunlin Zhao, Sheng Ju, Qifan Li, Zhike Chen, Cheng Ding, Xin Tong, Jun Zhao

Colorectal cancer concurrent gene signature based on coherent patterns between genomic and transcriptional alterations

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Ming-Hung Shen, Chi-Jung Huang, Thien-Fiew Ho, Chih-Yi Liu, Ying-Yih Shih, Ching-Shui Huang, Chi-Cheng Huang

Multinomial network meta-analysis using response rates: relapsed/refractory multiple myeloma treatment rankings differ depending on the choice of outcome

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Chrissy H. Y. van Beurden-Tan, Pieter Sonneveld, Carin A. Uyl-de Groot

Correction: Identification and validation of TNFRSF4 as a high-profile biomarker for prognosis and immunomodulation in endometrial carcinoma

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Heng Ma, Peng-Hui Feng, Shuang-ni Yu, Zhao-Hui Lu, Qi Yu, Jie Chen

Timing of adjuvant chemotherapy initiation and mortality among colon cancer patients at a safety-net health system

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Yan Lu, Aaron W. Gehr, Rachel J. Meadows, Bassam Ghabach, Latha Neerukonda, Kalyani Narra, Rohit P. Ojha

Nitric-Oxide Synthase trafficking inducer (NOSTRIN) is an emerging negative regulator of colon cancer progression

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Madhurima Paul, Tamal Kanti Gope, Priyanka Das, Rupasri Ain

Tescalcin promotes highly invasive papillary thyroid microcarcinoma by regulating FOS/ERK signaling pathway

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Xiuhe Zou, Qian Zhou, Yan Nie, Junhe Gou, Jing Yang, Jingqiang Zhu, Zhihui Li, Yanping Gong

Higher body mass index was associated with better prognosis in diabetic patients with stage II colorectal cancer

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Xiao-Yu Liu, Bing Kang, Yu-Xi Cheng, Chao Yuan, Wei Tao, Bin Zhang, Zheng-Qiang Wei, Dong Peng

Efficacy of osimertinib in epidermal growth factor receptor-mutated non-small-cell lung cancer patients with pleural effusion

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Hiroshi Nokihara, Hirokazu Ogino, Atsushi Mitsuhashi, Kensuke Kondo, Ei Ogawa, Ryohiko Ozaki, Yohei Yabuki, Hiroto Yoneda, Kenji Otsuka, Yasuhiko Nishioka

Significance of tumor heterogeneity of p-Smad2 and c-Met in HER2-positive gastric carcinoma with lymph node metastasis

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Gen Tsujio, Koji Maruo, Yurie Yamamoto, Tomohiro Sera, Atsushi Sugimoto, Hiroaki Kasashima, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira, Masakazu Yashiro

BARD1 mystery: tumor suppressors are cancer susceptibility genes

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Yousef M. Hawsawi, Anwar Shams, Abdulrahman Theyab, Wed A. Abdali, Nahed A. Hussien, Hanan E. Alatwi, Othman R. Alzahrani, Atif Abdulwahab A. Oyouni, Ahmad O. Babalghith, Mousa Alreshidi

Completeness and selection bias of a Belgian multidisciplinary, registration-based study on the EFFectiveness and quality of Endometrial Cancer Treatment (EFFECT)

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Joren Vanbraband, Nancy Van Damme, Gauthier Bouche, Geert Silversmit, Anke De Geyndt, Eric de Jonge, Gerd Jacomen, Frédéric Goffin, Hannelore Denys, Frédéric Amant

Associations of different immune checkpoints-expressing CD4+ Treg/ T cell subsets with disease-free survival in colorectal cancer patients

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Mohammad A. Al-Mterin, Khaled Murshed, Alhasan Alsalman, Ala Abu-Dayeh, Eyad Elkord

MUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway

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Wei Su, Baijie Feng, Lina Hu, Xianzhi Guo, Minghua Yu

Gastrointestinal/genitourinary perforation and fistula formation with or without bevacizumab in patients with previously irradiated recurrent cervical cancer: a Korean multicenter retrospective study of the Gynecologic Oncology Research Investigators Collaboration (GORILLA) group (GORILLA-1001)

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Woo Yeon Hwang, Suk-Joon Chang, Hee Seung Kim, Nam Kyeong Kim, Tae Hun Kim, Yeorae Kim, Tae Wook Kong, Eun Ji Lee, Soo Jin Park, Seung Hyuk Shim, Joo-Hyuk Son, Dong Hoon Suh, Eun Jung Yang

Beyond standard data collection – the promise and potential of BRAIN (Brain tumour Registry Australia INnovation and translation registry)

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Lucy Gately, Katharine Drummond, Mark Rosenthal, Rosemary Harrup, Anthony Dowling, Andrew Gogos, Zarnie Lwin, Ian Collins, David Campbell, Elizabeth Ahern, Claire Phillips, Hui K. Gan, Iwan Bennett, Oliver M. Sieber, Peter Gibbs

Global DNA hypomethylation of colorectal tumours detected in tissue and liquid biopsies may be related to decreased methyl-donor content

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Krisztina A. Szigeti, Alexandra Kalmár, Orsolya Galamb, Gábor Valcz, Barbara K. Barták, Zsófia B. Nagy, Sára Zsigrai, Ildikó Felletár, Árpád V. Patai, Tamás Micsik, Márton Papp, Eszter Márkus, Zsolt Tulassay, Peter Igaz, István Takács, Béla Molnár

A novel tool for predicting the risk of central lymph node metastasis in patients with papillary thyroid microcarcinoma: a retrospective cohort study

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Qian-wen Luo, Shan Gao, Xiao Lv, Si-jia Li, Bo-fang Wang, Qing-qing Han, Yun-peng Wang, Quan-lin Guan, Tao Gong

Prognostic factors for patients with anal cancer treated with conformal radiotherapy—a systematic review

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Stelios Theophanous, Robert Samuel, John Lilley, Ann Henry, David Sebag-Montefiore, Alexandra Gilbert, Ane L. Appelt

Prognostic value of tumor-infiltrating CD163+macrophage in patients with metastatic gastric cancer undergoing multidisciplinary treatment

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Jun Kinoshita, Sachio Fushida, Takahisa Yamaguchi, Hideki Moriyama, Hiroto Saito, Mari Shimada, Shiro Terai, Koichi Okamoto, Keishi Nakamura, Itasu Ninomiya, Shintaro Yagi, Noriyuki Inaki

Prognostic value of disseminated tumor cells in unresectable pancreatic ductal adenocarcinoma: a prospective observational study

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Oddmund Nordgård, Morten Lapin, Kjersti Tjensvoll, Satu Oltedal, Karin Hestnes Edland, Nicolay Bore Neverdahl, Dmitrij Fostenes, Herish Garresori, Nils Glenjen, Rune Smaaland, Bjørnar Gilje

The role of sentinel node tumor burden in modeling the prognosis of melanoma patients with positive sentinel node biopsy: an Italian melanoma intergroup study (N = 2,086)

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Saveria Tropea, Paolo Del Fiore, Andrea Maurichi, Roberto Patuzzo, Mario Santinami, Simone Ribero, Pietro Quaglino, Virginia Caliendo, Lorenzo Borgognoni, Serena Sestini, Giuseppe Giudice, Eleonora Nacchiero, Corrado Caracò, Adriana Cordova, Nicola Solari, Dario Piazzalunga, Francesca Tauceri, Paolo Carcoforo, Maurizio Lombardo, Sara Cavallari, Simone Mocellin, Maddalena Cespa, Rosachiara Forcignanò, Gianmichele Moise, Maria Concetta Fargnoli, Caterina Ferreli, Maria Grimaldi, Guido Zannetti, Saverio Cinieri, Giusto Trevisan, Ignazio Stanganelli, Giovanna Moretti, Francesca Bruder, Luca Bianchi, Maria Teresa Fierro, Luigi Mascheroni, Salvatore Asero, Caterina Catricalà, Stefania Staibano, Gaetana Rinaldi, Riccardo Pellicano, Laura Milesi, Marilena Visini, Franco Di Filippo, Leonardo Zichichi, Maria Antonietta Pizzichetta, Carmelo Iacono, Massimo Guidoboni, Giovanni Sanna, Michele Maio, Michele Del Vecchio, Lucia Lospalluti, Leonardi Vita, Annamaria Pollio, Carlo Riberti

Pyroptosis-related prognosis model, immunocyte infiltration characterization, and competing endogenous RNA network of glioblastoma

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Min-Rui Ding, Yan-Jie Qu, Xiao Peng, Jin-Fang Chen, Meng-Xue Zhang, Tong Zhang, Bing Hu, Hong-Mei An

Simulating the restoration of normal gene expression from different thyroid cancer stages using deep learning

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Nicole M. Nelligan, M. Reed Bender, F. Alex Feltus

A stratification model of hepatocellular carcinoma based on expression profiles of cells in the tumor microenvironment

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Chunting Zeng, Linmeng Zhang, Chanhua Luo, Chen Yang, Xiaowen Huang, Linfeng Fan, Jiarong Li, Fengsheng Chen, Zelong Luo

Is it sufficient to evaluate metastatic bone involvement in breast cancer using SPECT/CT? A new approach of SPECT/CT-guided targeted bone marrow biopsy

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Xiaomin Li, Caixia An, Wanchun Zhang

A predictive model for advanced oropharyngeal cancer patients treated with chemoradiation

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Wu-Chia Lo, Chih-Ming Chang, Chia-Yun Wu, Chen-Hsi Hsieh, Pei-Wei Shueng, Po-Wen Cheng, Li-Jen Liao

Comparing the efficacy and safety of cisplatin and other platinum-based chemotherapies in locally advanced nasopharyngeal carcinoma: a systematic review and meta-analysis

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Zhiru Li, Chao Li, Dong Yang, Junmei Song, Ting Liu, Ziyan Zhou, Lifang Zhou, Min Kang

Real-world treatment sequencing and survival in previously treated advanced renal cell carcinoma patients receiving nivolumab monotherapy: a UK retrospective cohort study

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T. Waddell, K. Fife, R. Griffiths, A. Sharma, P. Dhokia, L. Groves, M. Hurst, C. Tsang, D. Sugrue, S. McKenna, J. Houghton, R. Carroll

The genomic and transcriptome characteristics of lung adenocarcinoma patients with previous breast cancer

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Yan Wang, Wenpeng Song, Sicheng Zhou, Shuai Chang, Junke Chang, Jie Tian, Liming Zhang, Jue Li, Guowei Che

An iron metabolism and immune related gene signature for the prediction of clinical outcome and molecular characteristics of triple-negative breast cancer

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Xiao-Fen Li, Wen-Fen Fu, Jie Zhang, Chuan-Gui Song

Potential prognosis index for m6A-related mRNA in cholangiocarcinoma

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Huaqiang Zhu, Haini Zhao, Jianlu Wang, Shuchao Zhao, Chaoqun Ma, Dongliang Wang, Hengjun Gao, Faji Yang, Qingqiang Ni, Hongguang Li, Xu Zhou, Chunqing Zhang, Jun Lu

Is treatment in certified cancer centers related to better survival in patients with pancreatic cancer? Evidence from a large German cohort study

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Martin Roessler, Jochen Schmitt, Christoph Bobeth, Michael Gerken, Kees Kleihues-van Tol, Christoph Reissfelder, Bettina M. Rau, Marius Distler, Pompiliu Piso, Christian Günster, Monika Klinkhammer-Schalke, Olaf Schoffer, Veronika Bierbaum

Linking unfolded protein response to ovarian cancer cell fusion

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Lucile Yart, Daniel Bastida-Ruiz, Mathilde Allard, Pierre-Yves Dietrich, Patrick Petignat, Marie Cohen

T-DM1 efficacy in trastuzumab-pertuzumab pre-treated HER2 positive metastatic breast cancer patients: a meta-analysis

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Claudia Omarini, Federico Piacentini, Isabella Sperduti, Krisida Cerma, Monica Barbolini, Fabio Canino, Cecilia Nasso, Christel Isca, Federica Caggia, Massimo Dominici, Luca Moscetti

Suboptimal use of hormonal therapy among German men with localized high-risk prostate Cancer during 2005 to 2015: analysis of registry data

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Semaw Ferede Abera, Ahmed Bedir, André Glowka, Dirk Vordermark, Daniel Medenwald

Rationale and design of ON-TRK: a novel prospective non-interventional study in patients with TRK fusion cancer treated with larotrectinib

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• Study protocol

James C. H. Yang, Marcia S. Brose, Gilberto Castro, Edward S. Kim, Ulrik N. Lassen, Serge Leyvraz, Alberto Pappo, Fernando López-Ríos, John A. Reeves, Marc Fellous, Frédérique Penault-Llorca, Erin R. Rudzinski, Ghazaleh Tabatabai, Gilles Vassal, Alexander Drilon, Jonathan Trent

Cetuximab and anemia prevention in head and neck cancer patients undergoing radiotherapy

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Lucas Maahs, Ahmed I. Ghanem, Radhika Gutta, Amy Tang, Swarn Arya, Zaid Al Saheli, Haythem Ali, Steven Chang, Samantha Tam, Vivian Wu, Farzan Siddiqui, Jawad Sheqwara

Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer

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Nanda Kumar Yellapu, Thuc Ly, Mihaela E. Sardiu, Dong Pei, Danny R. Welch, Jeffery A. Thompson, Devin C. Koestler

Interfering with the expression of EEF1D gene enhances the sensitivity of ovarian cancer cells to cisplatin

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Qia Xu, Yun Liu, Shenyi Wang, Jing Wang, Liwei Liu, Yin Xu, Yide Qin

Outcomes from a mechanistic biomarker multi-arm and randomised study of liposomal MTP-PE (Mifamurtide) in metastatic and/or recurrent osteosarcoma (EuroSarc-Memos trial)

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David J. Barnes, Peter Dutton, Øyvind Bruland, Hans Gelderblom, Ade Faleti, Claudia Bühnemann, Annemiek van Maldegem, Hannah Johnson, Lisa Poulton, Sharon Love, Gesa Tiemeier, Els van Beelen, Karin Herbschleb, Caroline Haddon, Lucinda Billingham, Kevin Bradley, Stefano Ferrari, Emanuela Palmerini, Piero Picci, Uta Dirksen, Sandra J. Strauss, Pancras C. W. Hogendoorn, Emmeline Buddingh, Jean-Yves Blay, Anne Marie Cleton-Jansen, Andrew Bassim Hassan

LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression

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Xuexue Xu, Pengsheng Ding, Lan Shi, Gang Wu, Xiaoling Ma

Clinical determinants of recurrence in pTa bladder cancer following transurethral resection of bladder tumor

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Seung-hwan Jeong, Jang Hee Han, Chang Wook Jeong, Hyeon Hoe Kim, Cheol Kwak, Hyeong Dong Yuk, Ja Hyeon Ku

Semaphorin 4B promotes tumor progression and associates with immune infiltrates in lung adenocarcinoma

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Jun Jiang, Yuan Lu, Fang Zhang, Tao Pan, Zhipei Zhang, Yi Wan, Xinling Ren, Rui Zhang

Identification and validation of a seven m6A-related lncRNAs signature predicting prognosis of ovarian cancer

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Yang Song, Hui Qu

Meta-analysis of diagnostic cell-free circulating microRNAs for breast cancer detection

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Emir Sehovic, Sara Urru, Giovanna Chiorino, Philipp Doebler

Impact of AADAC gene expression on prognosis in patients with Borrmann type III advanced gastric cancer

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Yufei Wang, Tianyi Fang, Yimin Wang, Xin Yin, Lei Zhang, Xinghai Zhang, Daoxu Zhang, Yao Zhang, Xibo Wang, Hao Wang, Yingwei Xue

The identification and validation of EphA7 hypermethylation, a novel biomarker, in cervical cancer

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Wenfan Zhang, Huiling Cao, Jinhao Yang, Jing Zhao, Zheng Liang, Xiaodong Kang, Rong Wang

Post-recurrence survival analysis in patients with oligo-recurrence after curative esophagectomy

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Ping-Chung Tsai, Hung-Che Chien, Po-Kuei Hsu, Jung-Jyh Hung, Chien-Sheng Huang, Wen-Hu Hsu, Han-Shui Hsu

Novel γδ T cell-based prognostic signature to estimate risk and aid therapy in hepatocellular carcinoma

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Jingrui Wang, Sunbin Ling, Jie Ni, Yafeng Wan

YAP1 is essential for malignant mesothelioma tumor maintenance

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Loreley Calvet, Odette Dos-Santos, Emmanuel Spanakis, Véronique Jean-Baptiste, Jean-Christophe Le Bail, Armelle Buzy, Pascal Paul, Christophe Henry, Sandrine Valence, Colette Dib, Jack Pollard, Sukhvinder Sidhu, Jürgen Moll, Laurent Debussche, Iris Valtingojer

Synchronous multiple primary tumors in patients with malignant lymphoma: a retrospective study

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Yu Yagi, Yusuke Kanemasa, Yuki Sasaki, An Ohigashi, Yuka Morita, Taichi Tamura, Shohei Nakamura, Akihiko Kageyama, Yasushi Omuro, Tatsu Shimoyama

Combined analysis of preoperative and postoperative lymphocyte-C-reactive protein ratio precisely predicts outcomes of patients with gastric cancer

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Kozo Miyatani, Shohei Sawata, Masahiro Makinoya, Wataru Miyauchi, Shota Shimizu, Yuji Shishido, Tomoyuki Matsunaga, Manabu Yamamoto, Naruo Tokuyasu, Shuichi Takano, Teruhisa Sakamoto, Toshimichi Hasegawa, Hiroaki Saito, Yoshiyuki Fujiwara

Integrative analysis of cell adhesion molecules in glioblastoma identified prostaglandin F2 receptor inhibitor (PTGFRN) as an essential gene

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Uchurappa Mala, Tapan Kumar Baral, Kumaravel Somasundaram

Development and validation of a prognostic scoring system for patients with colorectal cancer hepato-pulmonary metastasis: a retrospective study

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Shenghe Deng, Zhenxing Jiang, Yinghao Cao, Junnan Gu, Fuwei Mao, Yifan Xue, Le Qin, Ke Liu, Jiliang Wang, Ke Wu, Kailin Cai

Development and validation of a novel mitophagy-related gene prognostic signature for glioblastoma multiforme

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Jinghua Wang, Xinqi Qiu, Jiayu Huang, Zewei Zhuo, Hao Chen, Ruijie Zeng, Huihuan Wu, Kehang Guo, Qi Yang, Huiling Ye, Wei Huang, Yujun Luo

Improvement of functional outcome for patients with newly diagnosed grade 2 or 3 gliomas with co-deletion of 1p/19q – IMPROVE CODEL: the NOA-18 trial

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• Study protocol

A. Wick, A. Sander, M. Koch, M. Bendszus, S. Combs, T. Haut, A. Dormann, S. Walter, M. Pertz, J. Merkle-Lock, N. Selkrig, R. Limprecht, L. Baumann, M. Kieser, F. Sahm, U. Schlegel, F. Winkler, M. Platten, W. Wick, T. Kessler

The LEGACy study: a European and Latin American consortium to identify risk factors and molecular phenotypes in gastric cancer to improve prevention strategies and personalized clinical decision making globally

• Open Access
• Study protocol

Tessa Suzanne van Schooten, Sarah Derks, Elena Jiménez-Martí, Fatima Carneiro, Ceu Figueiredo, Erika Ruiz, Maria Alsina, Cristina Molero, Marcelo Garrido, Arnoldo Riquelme, Carmelo Caballero, Eva Lezcano, Juan Manuel O’Connor, Federico Esteso, Judith Farrés, José Manuel Mas, Florian Lordick, Jeannette Vogt, Antonella Cardone, Charis Girvalaki, Andrés Cervantes, Tania Fleitas

Correction: Dynamic trajectory of platelet counts after the first cycle of induction chemotherapy in AML patients

• Open Access
• Correction

Yazhen Bi, Zhaohui Wang, Saran Feng, Yan Wang, Yang Zhao, Hong Li, Jingyi Yu, Qian Liu, Chuansheng Zhu, Mingzhuo Li

Eat, sleep, play: health behaviors and their association with psychological health among cancer survivors in a nationally representative sample

• Open Access
• Research article

Trevin E. Glasgow, Kandace P. McGuire, Bernard F. Fuemmeler

Postoperative hyperprogression disease of pancreatic ductal adenocarcinoma after curative resection: a retrospective cohort study

• Open Access
• Research article

Siyi Zou, Xinjing Wang, Haoda Chen, Jiewei Lin, Chenlei Wen, Qian Zhan, Hao Chen, Xiongxiong Lu, Xiaxing Deng, Baiyong Shen

Effects of pre-operative enteral immunonutrition for esophageal cancer patients treated with neoadjuvant chemoradiotherapy: protocol for a multicenter randomized controlled trial (point trial, pre-operative immunonutrition therapy)

• Open Access
• Study protocol

Yuqin Cao, Dingpei Han, Su Yang, Yongmei Shi, Shengguang Zhao, Qianwen Jin, Jian Li, Chengqiang Li, Yajie Zhang, Weiyu Shen, Jinxian He, Mingsong Wang, Guangyu Ji, Zhigang Li, Yi He, Qixun Chen, Weitian Wei, Chun Chen, Xian Gong, Jinyi Wang, Lijie Tan, Hao Wang, Hecheng Li

Evaluating an interactive acceptance and commitment therapy (ACT) workshop delivered to trained therapists working with cancer patients in the United Kingdom: a mixed methods approach

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Elisavet Moschopoulou, Debbie Brewin, Damien Ridge, Sheila Donovan, Stephanie J. C. Taylor, Liam Bourke, Gail Eva, Imran Khan, Trudie Chalder, Kamaldeep Bhui, Liam Bourke, Trudie Chalder, Gail Eva, John Gribben, Ms Miriam Harris, Louise Jones, Ania Korszun, Paul Little, Paul McCrone, Adrienne Morgan, Damien Ridge, Rebecca Roylance, Stephanie J. C. Taylor, Mohamed Thaha, Peter White

Integrative medicine during the intensive phase of chemotherapy in pediatric oncology in Germany: a randomized controlled trial with 5-year follow up

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Georg Seifert, Sarah B. Blakeslee, Gabriele Calaminus, Farid I. Kandil, Andrea Barth, Toralf Bernig, Carl Friedrich Classen, Selim Corbacioglu, Jürgen Föll, Sven Gottschling, Bernd Gruhn, Claudia vom Hoff-Heise, Holger N. Lode, David Martin, Michaela Nathrath, Felix Neunhoeffer, Arnulf Pekrun, Beate Wulff, Tycho Zuzak, Günter Henze, Alfred Längler

Quantitative and qualitative changes in platelet traits of sunitinib-treated patients with renal cell carcinoma in relation to circulating sunitinib levels: a proof-of-concept study

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Bibian M. E. Tullemans, Sanne L. N. Brouns, Frauke Swieringa, Siamack Sabrkhany, Franchette W. P. J. van den Berkmortel, Natascha A. J. B. Peters, Peter de Bruijn, Stijn L. W. Koolen, Johan W. M. Heemskerk, Maureen J. B. Aarts, Marijke J. E. Kuijpers

Clinical efficacy of osimertinib in EGFR-mutant non-small cell lung cancer with distant metastasis

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Soei Gen, Ichidai Tanaka, Masahiro Morise, Junji Koyama, Yuta Kodama, Akira Matsui, Ayako Miyazawa, Tetsunari Hase, Yoshitaka Hibino, Toshihiko Yokoyama, Tomoki Kimura, Norio Yoshida, Mitsuo Sato, Naozumi Hashimoto

Impact of the initial site of metastases on post-recurrence survival for neuroendocrine cervical cancer

• Open Access
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Baoyue Pan, Ting Wan, Yinan Jiang, Xiaojing Zheng, Pingping Liu, Huiling Xiang, Min Zheng

Nutrition-wide association study of microbiome diversity and composition in colorectal cancer patients

• Open Access
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Tung Hoang, Min Jung Kim, Ji Won Park, Seung-Yong Jeong, Jeeyoo Lee, Aesun Shin

Necessity of external iliac lymph nodes and inguinal nodes radiation in rectal cancer with anal canal involvement

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Rong Zheng, YaZhen Zhang, RunFan Chen, Bingjie Guan, YuPing Lin, BiSi Wang, XiaoBo Li, Pan Chi, XiaoPing Chen, BenHua Xu

The effect of HPV DNA and p16 status on the prognosis of patients with hypopharyngeal carcinoma: a meta-analysis

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Jinfeng Shi, Ling Wang, Nan Yao, Le Sun, Wenyu Hu, Xiaotong Li, Yixue Yang, Yusheng Wang, Wei Zhu, Bo Li

Hiccups in patients with cancer: a multi-site, single-institution study of etiology, severity, complications, interventions, and outcomes

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Christopher J. Ehret, Yahya Almodallal, Jennifer G. Le-Rademacher, Nichole A. Martin, Michael R. Moynagh, Arush Rajotia, Aminah Jatoi

Circulating tumour cell gene expression and chemosensitivity analyses: predictive accuracy for response to multidisciplinary treatment of patients with unresectable refractory recurrent rectal cancer or unresectable refractory colorectal cancer liver metastases

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Stefano Guadagni, Francesco Masedu, Giammaria Fiorentini, Donatella Sarti, Caterina Fiorentini, Veronica Guadagni, Panagiotis Apostolou, Ioannis Papasotiriou, Panagiotis Parsonidis, Marco Valenti, Enrico Ricevuto, Gemma Bruera, Antonietta R. Farina, Andrew R. Mackay, Marco Clementi

Intratumoral fibrosis and patterns of immune infiltration in clear cell renal cell carcinoma

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Songchen Han, Wenbo Yang, Caipeng Qin, Yiqing Du, Mengting Ding, Huaqi Yin, Tao Xu

KAZN as a diagnostic marker in ovarian cancer: a comprehensive analysis based on microarray, mRNA-sequencing, and methylation data

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Songling Zhu, Hongxia Bao, Meng-Chun Zhang, Huidi Liu, Yao Wang, Caiji Lin, Xingjuan Zhao, Shu-Lin Liu

The study of direct and indirect effects of radiofrequency ablation on tumor microenvironment in liver tumor animal model

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An-Na Jiang, Bing Wang, Song Wang, Kun Zhao, Hao Wu, Kun Yan, Wei Wu, Wei Yang

Tumor and peritumor radiomics analysis based on contrast-enhanced CT for predicting early and late recurrence of hepatocellular carcinoma after liver resection

• Open Access
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Nu Li, Xiaoting Wan, Hong Zhang, Zitian Zhang, Yan Guo, Duo Hong

Editorial Expression of Concern: FOXO/TXNIP pathway is involved in the suppression of hepatocellular carcinoma growth by glutamate antagonist MK-801

• Open Access
• Editorial Expression of Concern

Fuminori Yamaguchi, Yuko Hirata, Hossain Akram, Kazuyo Kamitori, Youyi Dong, Li Sui, Masaaki Tokuda

CKAP2L, a crucial target of miR-326, promotes prostate cancer progression

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Qi Li, Mo Yan, Chunhui Wang, Kaibin Wang, Guochang Bao

Comprehensive analysis reveals COPB2 and RYK associated with tumor stages of larynx squamous cell carcinoma

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Guojin Zhou, Shoude Zhang, Mao Jin, Sunhong Hu

Investigation of BRCAness associated miRNA-gene axes in breast cancer: cell-free miR-182-5p as a potential expression signature of BRCAness

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Farzaneh Darbeheshti, Sepideh Kadkhoda, Mahsa Keshavarz-Fathi, Sepideh Razi, Afshin Bahramy, Yaser Mansoori, Nima Rezaei

MIF/CXCR4 signaling axis contributes to survival, invasion, and drug resistance of metastatic neuroblastoma cells in the bone marrow microenvironment

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Laura Garcia-Gerique, Marta García, Alícia Garrido-Garcia, Soledad Gómez-González, Montserrat Torrebadell, Estela Prada, Guillem Pascual-Pasto, Oscar Muñoz, Sara Perez-Jaume, Isadora Lemos, Noelia Salvador, Monica Vila-Ubach, Ana Doncel-Requena, Mariona Suñol, Angel M. Carcaboso, Jaume Mora, Cinzia Lavarino

Irregular delay of adjuvant chemotherapy correlated with poor outcome in stage II-III colorectal cancer

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Yuanyuan Chen, Mingyue Xu, Qianwen Ye, Jia Xiang, Tianhui Xue, Tao Yang, Long Liu, Bing Yan

Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-catenin

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Binyu Qin, Zhili Zeng, Jianliang Xu, Jing Shangwen, Zeng Jie Ye, Shutang Wang, Yanheng Wu, Gongfeng Peng, Qi Wang, Wenyi Gu, Ying Tang

Predictive value of baseline metabolic tumor volume in early-stage favorable Hodgkin Lymphoma – Data from the prospective, multicenter phase III HD16 trial

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Lutz van Heek, Colin Stuka, Helen Kaul, Horst Müller, Jasmin Mettler, Felicitas Hitz, Christian Baues, Michael Fuchs, Peter Borchmann, Andreas Engert, Markus Dietlein, Conrad-Amadeus Voltin, Carsten Kobe

A novel carbon-fibre adjustable reusable accessory (CARA) for supine breast positioning to reduce toxicity in breast adjuvant radiotherapy: a study protocol for a multicentre phase III randomized controlled trial

• Open Access
• Study protocol

Cheryl Duzenli, Elisa K. Chan, Alanah M. Bergman, Sheri Grahame, Joel Singer, Levi Burns, Robert A. Olson

A network meta-analysis for efficacies and toxicities of different concurrent chemoradiotherapy regimens in the treatment of locally advanced non-small cell lung cancer

• Open Access
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Qiangqiang Zheng, Shihui Min, Yunfeng Zhou

Contribution and clinical relevance of germline variation to the cancer transcriptome

• Open Access
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Bernard Pereira, Emma Labrot, Eric Durand, Joshua M. Korn, Audrey Kauffmann, Catarina D. Campbell

The feasibility of proteomics sequencing based immune-related prognostic signature for predicting clinical outcomes of bladder cancer patients

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Liren Jiang, Siteng Chen, Qi Pan, Jun Zheng, Jin He, Juanjuan Sun, Yaqin Han, Jiji Yang, Ning Zhang, Guohui Fu, Feng Gao

Mass cytometry reveals immune atlas of urothelial carcinoma

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Qing Zhang, Wenlong Zhang, Tingsheng Lin, Wenfeng Lu, Xin He, Yuanzhen Ding, Wei Chen, Wenli Diao, Meng Ding, Pingping Shen, Hongqian Guo

Exploring complement-dependent cytotoxicity by rituximab isotypes in 2D and 3D-cultured B-cell lymphoma

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Sandra Lara, Juliane Heilig, Alexander Virtanen, Sandra Kleinau

Anti-lipolysis-stimulated lipoprotein receptor monoclonal antibody as a novel therapeutic agent for endometrial cancer

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Yoshikazu Nagase, Kosuke Hiramatsu, Masashi Funauchi, Mayu Shiomi, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Ai Miyoshi, Shinya Matsuzaki, Eiji Kobayashi, Toshihiro Kimura, Satoshi Serada, Yutaka Ueda, Tetsuji Naka, Tadashi Kimura

Neuroendocrine pathways and breast cancer progression: a pooled analysis of somatic mutations and gene expression from two large breast cancer cohorts

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Kejia Hu, Chengshi Wang, Chuanxu Luo, Hong Zheng, Huan Song, Jacob Bergstedt, Katja Fall, Ting Luo, Kamila Czene, Unnur A. Valdimarsdóttir, Fang Fang, Donghao Lu

The clinicopathological and prognostic value of CXCR4 expression in patients with lung cancer: a meta-analysis

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Liping Qiu, Yuanyuan Xu, Hui Xu, Biyun Yu

Incidental irradiation of the regional lymph nodes during deep inspiration breath-hold radiation therapy in left-sided breast cancer patients: a dosimetric analysis

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Jule Wolf, Steffen Kurz, Thomas Rothe, Marco Serpa, Jutta Scholber, Thalia Erbes, Eleni Gkika, Dimos Baltas, Vivek Verma, David Krug, Ingolf Juhasz-Böss, Anca-Ligia Grosu, Nils H. Nicolay, Tanja Sprave

Preoperative PDW levels predict pulmonary metastasis in patients with hepatocellular carcinoma

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Wen-juan Huang, Guang-yu Wang, Zeng-yao Liu, Meng-lin Zhang, Wen Wang, Xin Zhang, Rui-tao Wang

Advanced lung cancer inflammation index (ALI) predicts prognosis of patients with gastric cancer after surgical resection

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Xin Zhang, Danfang Wang, Tuanhe Sun, Wenxing Li, Chengxue Dang

Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis

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Xuewei Hao, Jun Zhang, Guoyou Chen, Weiwei Cao, Hongyang Chen, Shuo Chen

Development and validation of reassigned CEA, CYFRA21-1 and NSE-based models for lung cancer diagnosis and prognosis prediction

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Jingmin Yuan, Yan Sun, Ke Wang, Zhiyi Wang, Duo Li, Meng Fan, Xiang Bu, Jun Chen, Zhiquan Wu, Hui Geng, Jiamei Wu, Ying Xu, Mingwei Chen, Hui Ren

Exploring the potential mechanism of emetine against coronavirus disease 2019 combined with lung adenocarcinoma: bioinformatics and molecular simulation analyses

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Kun Zhang, Ke Wang, Chaoguo Zhang, Xiuli Teng, Dan Li, Mingwei Chen

Effect of musculature on mortality, a retrospective cohort study

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Amy L. Shaver, Mary E. Platek, Anurag K. Singh, Sung Jun Ma, Mark Farrugia, Gregory Wilding, Andrew D. Ray, Heather M. Ochs-Balcom, Katia Noyes

miR-2682-3p antagonizes its host lncRNA-MIR137HG by interacting with the same target FUS to regulate the progression of gastric cancer

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Yantao Du, Yichen Chen, Tao Wu, Xiaodan Fan, Wei Lin, Zhouhua Jiang

Identification and clinical validation of NUSAP1 as a novel prognostic biomarker in ovarian cancer

• Open Access
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Rui Gou, Mingjun Zheng, Yuexin Hu, Lingling Gao, Shuang Wang, Ouxuan Liu, Xiao Li, Liancheng Zhu, Juanjuan Liu, Bei Lin

A promising Prognostic risk model for advanced renal cell carcinoma (RCC) with immune-related genes

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Peng Cao, Ji-Yue Wu, Jian-Dong Zhang, Ze-Jia Sun, Xiang Zheng, Bao-Zhong Yu, Hao-Yuan Cao, Fei-Long Zhang, Zi-Hao Gao, Wei Wang

Comprehensive bioinformatic analysis reveals a cancer-associated fibroblast gene signature as a poor prognostic factor and potential therapeutic target in gastric cancer

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Cemre Ucaryilmaz Metin, Gulnihal Ozcan

Malignant pleural mesothelioma: treatment patterns and humanistic burden of disease in Europe

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Adam Moore, Bryan Bennett, Gavin Taylor-Stokes, Laura McDonald, Melinda J. Daumont

A novel pyroptosis-related lncRNA prognostic signature associated with the immune microenvironment in lung squamous cell carcinoma

• Open Access
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Wei Zhou, Wenxiong Zhang

Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations

• Open Access
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Katharina Nimptsch, Krasimira Aleksandrova, Veronika Fedirko, Mazda Jenab, Marc J. Gunter, Peter D. Siersema, Kana Wu, Verena Katzke, Rudolf Kaaks, Salvatore Panico, Domenico Palli, Anne M May, Sabina Sieri, Bas Bueno-de-Mesquita, Karina Standahl, Maria-Jose Sánchez, Aurora Perez-Cornago, Anja Olsen, Anne Tjønneland, Catalina Bonet Bonet, Christina C. Dahm, María-Dolores Chirlaque, Valentina Fiano, Rosario Tumino, Aurelio Barricarte Gurrea, Marie-Christine Boutron-Ruault, Florence Menegaux, Gianluca Severi, Bethany van Guelpen, Young-Ae Lee, Tobias Pischon

Characteristics and interplay of esophageal microbiota in esophageal squamous cell carcinoma

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Zheng Lin, Wenqing Rao, Zhisheng Xiang, Qiaoyan Zeng, Shuang Liu, Kaili Yu, Jinsong Zhou, Jianwen Wang, Weilin Chen, Yuanmei Chen, Xiane Peng, Zhijian Hu

Leukocyte subtyping predicts for treatment failure and poor survival in anal squamous cell carcinoma

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Daniel R. Principe, Jose L. Cataneo, Kaytlin E. Timbers, Regina M. Koch, Klara Valyi-Nagy, Anders Mellgren, Ajay Rana, Gerald Gantt

Correction: A novel tool for predicting the risk of central lymph node metastasis in patients with papillary thyroid microcarcinoma: a retrospective cohort study

• Open Access
• Correction

Qian-wen Luo, Shan Gao, Xiao Lv, Si-jia Li, Bo-fang Wang, Qing-qing Han, Yun-peng Wang, Quan-lin Guan, Tao Gong

Clinical relevance of tertiary lymphoid structures in esophageal squamous cell carcinoma

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Sota Deguchi, Hiroaki Tanaka, Shugo Suzuki, Seji Natsuki, Takuya Mori, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Takahiro Toyokawa, Shigeru Lee, Kazuya Muguruma, Hideki Wanibuchi, Masaichi Ohira

Prognostic importance of systemic inflammation and insulin resistance in patients with cancer: a prospective multicenter study

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Guo-Tian Ruan, Hai-Lun Xie, Yi-Zhen Gong, Yi-Zhong Ge, Qi Zhang, Zi-Wen Wang, Xi Zhang, He-Yang Zhang, Meng Tang, Meng-Meng Song, Xiao-Wei Zhang, Ming Yang, Yong-Bing Chen, Kai-Ying Yu, Li Deng, Kun-Hua Wang, Ming-Hua Cong, Han-Ping Shi

Isolated central nervous system relapses in patients with high-risk neuroblastoma -clinical presentation and prognosis: experience of the Polish Paediatric Solid Tumours Study Group

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Aleksandra Wieczorek, Joanna Stefanowicz, Marcin Hennig, Elzbieta Adamkiewicz-Drozynska, Marzena Stypinska, Bozenna Dembowska-Baginska, Zuzanna Gamrot, Mariola Woszczyk, Julia Geisler, Tomasz Szczepanski, Szymon Skoczen, Marek Ussowicz, Monika Pogorzala, Szymon Janczar, Walentyna Balwierz

Assessment of preoperative axillary nodal disease burden: breast MRI in locally advanced breast cancer before, during and after neoadjuvant endocrine therapy

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Joana Reis, Joao Boavida, Hang T. Tran, Marianne Lyngra, Laurens Cornelus Reitsma, Hossein Schandiz, Woldegabriel A. Melles, Kjell-Inge Gjesdal, Jürgen Geisler, Jonn Terje Geitung

Clinical implications of neoadjuvant chemotherapy in advanced endometrial cancer: a multi-center retrospective cohort study

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Hyunji Lim, Seung Hyun Bang, Yeorae Kim, Sang Hyun Cho, Wonkyo Shin, Se Ik Kim, Tae Hun Kim, Dong Hoon Suh, Myong Cheol Lim, Jae-Weon Kim

Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 in locally advanced laryngeal cancer as prognostic indicators of relapse and survival

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Giovanni Almadori, Antonella Coli, Eugenio De Corso, Dario Antonio Mele, Stefano Settimi, Giovanni Di Cintio, Francesca Brigato, Domenico Scannone, Libero Lauriola, Franco Oreste Ranelletti

Patient-centered research: how do women tolerate nipple fluid aspiration as a potential screening tool for breast cancer?

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Susana I. S. Patuleia, Cathy B. Moelans, Jasmijn Koopman, Julia E. C. van Steenhoven, Thijs van Dalen, Carmen C. van der Pol, Agnes Jager, Margreet G. E. M. Ausems, Paul J. van Diest, Elsken van der Wall, Karijn P. M. Suijkerbuijk

Polygenic risk scores indicate extreme ages at onset of breast cancer in female BRCA1/2 pathogenic variant carriers

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Julika Borde, Yael Laitman, Britta Blümcke, Dieter Niederacher, Konstantin Weber-Lassalle, Christian Sutter, Andreas Rump, Norbert Arnold, Shan Wang-Gohrke, Judit Horváth, Andrea Gehrig, Gunnar Schmidt, Véronique Dutrannoy, Juliane Ramser, Julia Hentschel, Alfons Meindl, Christopher Schroeder, Barbara Wappenschmidt, Christoph Engel, Karoline Kuchenbaecker, Rita K. Schmutzler, Eitan Friedman, Eric Hahnen, Corinna Ernst

Thymoquinone upregulates IL17RD in controlling the growth and metastasis of triple negative breast cancer cells in vitro

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Md. Asaduzzaman Khan, Meiling Zheng, Jiewen Fu, Mousumi Tania, Jun Li, Junjiang Fu

PIK3R3, a regulatory subunit of PI3K, modulates ovarian cancer stem cells and ovarian cancer development and progression by integrative analysis

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Eun Jung Sohn

Non-invasive diagnosis strategy of hepatocellular carcinoma in low-risk population

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Zonglin Xie, Zhenpeng Peng, Yujian Zou, Han Xiao, Bin Li, Qian Zhou, Shuling Chen, Lixia Xu, Jingxian Shen, Yunxian Mo, Sui Peng, Ming Kuang, Jianting Long, Shi-Ting Feng

A study protocol of a randomized phase II trial of perioperative chemoimmunotherapy verses perioperative chemoimmunotherapy plus preoperative chemoradiation for locally advanced gastric (G) or gastroesophageal junction (GEJ) adenocarcinoma: the NeoRacing study

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• Study protocol

Menglong Zhou, Wang Yang, Yan Xuan, Wei Zou, Yaqi Wang, Zhiyuan Zhang, Jing Zhang, Miao Mo, Changming Zhou, Yuan Liu, Wenming Zhang, Zhaozhen Zhang, Yiping He, Weiwei Weng, Cong Tan, Lei Wang, Dan Huang, Weiqi Sheng, Huanhuan Li, Hui Zhu, Yan Wang, Lijun Shen, Hui Zhang, Juefeng Wan, Guichao Li, Hua Huang, Yanong Wang, Zhen Zhang, Xiaowen Liu, Fan Xia

Impact of early tumor shrinkage on quality of life in patients treated with first-line cetuximab plus chemotherapy for unresectable metastatic colorectal cancer: results of Phase II QUACK trial

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Akira Ooki, Satoshi Morita, Akihito Tsuji, Shigeyoshi Iwamoto, Hiroki Hara, Hiroaki Tanioka, Hironaga Satake, Masato Kataoka, Masahito Kotaka, Yoshinori Kagawa, Masato Nakamura, Tatsushi Shingai, Masashi Ishikawa, Yasuhiro Miyake, Takeshi Suto, Yojiro Hashiguchi, Taichi Yabuno, Masahiko Ando, Junichi Sakamoto, Kensei Yamaguchi

High expression level of CXCL1/GROα is linked to advanced stage and worse survival in uterine cervical cancer and facilitates tumor cell malignant processes

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Xiaxia Man, Xiaolin Yang, Zhentong Wei, Yuying Tan, Wanying Li, Hongjuan Jin, Baogang Wang

Clinical significance and potential regulatory mechanism of overexpression of pituitary tumor-transforming gene transcription factor in bladder cancer

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Jian-Di Li, Abdirahman Ahmed Farah, Zhi-Guang Huang, Gao-Qiang Zhai, Rui-Gong Wang, Jia-Lin Liu, Qin-Jie Wang, Guan-Lan Zhang, Zi-Long Lei, Yi-Wu Dang, Sheng-Hua Li

Survival-related indicators ALOX12B and SPRR1A are associated with DNA damage repair and tumor microenvironment status in HPV 16-negative head and neck squamous cell carcinoma patients

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Jing Li, Ling-Long Tang, Jun Ma

A nomogram based on A-to-I RNA editing predicting overall survival of patients with lung squamous carcinoma

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Li Liu, Jun Liu, Xiaoliang Deng, Li Tu, Zhuxiang Zhao, Chenli Xie, Lei Yang

Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma

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Jing Zhu, Ruhua Fang, Zhiwen Pan, Xu Qian

Mutations of 1p genes do not consistently abrogate tumor suppressor functions in 1p-intact neuroblastoma

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Chik Hong Kuick, Jia Ying Tan, Deborah Jasmine, Tohari Sumanty, Alvin Y. J. Ng, Byrrappa Venkatesh, Huiyi Chen, Eva Loh, Sudhanshi Jain, Wan Yi Seow, Eileen H. Q. Ng, Derrick W. Q. Lian, Shui Yen Soh, Kenneth T. E. Chang, Zhi Xiong Chen, Amos H. P. Loh

Feasibility study of adjuvant chemotherapy with S-1 after curative esophagectomy following neoadjuvant chemotherapy for esophageal cancer

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Noriyuki Hirahara, Takeshi Matsubara, Shunsuke Kaji, Hikota Hayashi, Koki Kawakami, Yohei Sasaki, Satoshi Takao, Natsuko Takao, Ryoji Hyakudomi, Tetsu Yamamoto, Yoshitsugu Tajima

Ferroptosis-related long non-coding RNA signature predicts the prognosis of bladder cancer

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Jian Hou, Zhenquan Lu, Xiaobao Cheng, Runan Dong, Yi Jiang, Guoqing Wu, Genyi Qu, Yong Xu

A population-based validation study of the 8th edition UICC/AJCC TNM staging system for cutaneous melanoma

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Matthew C. Hynes, Paul Nguyen, Patti A. Groome, Yuka Asai, Meaghan E. Mavor, Tara D. Baetz, Timothy P. Hanna

N6-methyladenosine-related lncRNAs identified as potential biomarkers for predicting the overall survival of Asian gastric cancer patients

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Shuyu Xu, Wenlong Chen, Yiwen Wang, Yuxin Zhang, Rong Xia, Jiemiao Shen, Xing Gong, Yinyin Liang, Jiayi Xu, Hua Tang, Tie Zhao, Yi Zhang, Tao Chen, Chao Wang

Efficacy and safety of pomalidomide and low-dose dexamethasone in Chinese patients with relapsed or refractory multiple myeloma: a multicenter, prospective, single-arm, phase 2 trial

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Wei-Jun Fu, Ya-Fei Wang, Hong-Guo Zhao, Ting Niu, Bai-Jun Fang, Ai-Jun Liao, Hai Bai, Jin Lu

Genetic analysis of Japanese patients with small bowel adenocarcinoma using next-generation sequencing

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Atsushi Tatsuguchi, Takeshi Yamada, Koji Ueda, Hiroyasu Furuki, Aitoshi Hoshimoto, Takayoshi Nishimoto, Jun Omori, Naohiko Akimoto, Katya Gudis, Shu Tanaka, Shunji Fujimori, Akira Shimizu, Katsuhiko Iwakiri

Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells

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Cuiying He, Chengzhao Wang, Haisheng Liu, Baoen Shan

Alternative splicing of Apoptosis Stimulating Protein of TP53-2 (ASPP2) results in an oncogenic isoform promoting migration and therapy resistance in soft tissue sarcoma (STS)

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Vasileia Tsintari, Bianca Walter, Falko Fend, Mathis Overkamp, Christian Rothermundt, Charles D. Lopez, Marcus M. Schittenhelm, Kerstin M. Kampa-Schittenhelm

Electronic patient-reported monitoring of symptoms during follow-up of ovarian cancer patients: a feasibility study

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Fiona Kennedy, Leanne Shearsmith, Marie Holmes, Zoe Rogers, Rob Carter, Uschi Hofmann, Galina Velikova

Improving anticancer effect of aPD-L1 through lowering neutrophil infiltration by PLAG in tumor implanted with MB49 mouse urothelial carcinoma

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Guen Tae Kim, Eun Young Kim, Su-Hyun Shin, Hyowon Lee, Se Hee Lee, Ki-Young Sohn, Jae Wha Kim

RETRACTED ARTICLE: LncRNA NDRG1 aggravates osteosarcoma progression and regulates the PI3K/AKT pathway by sponging miR-96-5p

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Zhen Wang, Yanting Wei, Hao Zhu, Lingfeng Yu, Jie Zhu, Qixiu Han, Ziying Liu, Jianhao Huang, Yan Zhu, Gentao Fan, Qikai Tang, Ji Qian, Xi Chen, Guangxin Zhou

A bioinformatic analysis study of m7G regulator-mediated methylation modification patterns and tumor microenvironment infiltration in glioblastoma

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Xinrui Wu, Chuanyu Li, Zhisu Wang, Yundi Zhang, Shifan Liu, Siqi Chen, Shuai Chen, Wangrui Liu, Xiaoman Liu

Reliability and validity of proxy-SSPedi and mini-SSPedi in pediatric patients 2-7 years receiving cancer treatments

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Deborah Tomlinson, L. Lee Dupuis, Donna L. Johnston, Susan Kuczynski, Serina Patel, Tal Schechter, Emily Vettese, Mark Mairs, George A. Tomlinson, Lillian Sung

The survival impact of palliative chemotherapy dose modifications on metastatic colon cancer

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Mohd Naqib Zainal Abidin, Marhanis Salihah Omar, Farida Islahudin, Noraida Mohamed Shah

Determination of essential biomarkers in lung cancer: a real-world data study in Spain with demographic, clinical, epidemiological and pathological characteristics

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Mariano Provencio, Manuel Cobo, Delvys Rodriguez-Abreu, Virginia Calvo, Enric Carcereny, Alexandra Cantero, Reyes Bernabé, Gretel Benitez, Rafael López Castro, Bartomeu Massutí, Edel del Barco, Rosario García Campelo, Maria Guirado, Carlos Camps, Ana Laura Ortega, Jose Luis González Larriba, Alfredo Sánchez, Joaquín Casal, M. Angeles Sala, Oscar Juan-Vidal, Joaquim Bosch-Barrera, Juana Oramas, Manuel Dómine, Jose Manuel Trigo, Remei Blanco, Julia Calzas, Idoia Morilla, Airam Padilla, Joao Pimentao, Pedro A. Sousa, Maria Torrente

Retraction Note: FAM83H-AS1/miR-485-5p/MEF2D axis facilitates proliferation, migration and invasion of hepatocellular carcinoma cells

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• Retraction Note

Wenpeng Zhao, Jiang Guo, Honglu Li, Liang Cai, Youjia Duan, Xiaopu Hou, Zhenying Diao, Xihong Shao, Hongliu Du, Changqing Li

Integrated analysis reveals the dysfunction of signaling pathways in uveal melanoma

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Songlin Sun, Boxia Guo, Liang Xu, Rui Shi

Targeting autophagy increases the efficacy of proteasome inhibitor treatment in multiple myeloma by induction of apoptosis and activation of JNK

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Azam Salimi, Kema Marlen Schroeder, Mirle Schemionek-Reinders, Margherita Vieri, Saskia Maletzke, Deniz Gezer, Behzad Kharabi Masouleh, Iris Appelmann

Molecular pathology testing for non-small cell lung cancer: an observational study of elements currently present in request forms and result reports and the opinion of different stakeholders

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Kelly Dufraing, Kaat Van Casteren, Joke Breyne, Nicky D’Haene, Claude Van Campenhout, Sara Vander Borght, Karen Zwaenepoel, Etienne Rouleau, Ed Schuuring, Jan von der Thüsen, Elisabeth Dequeker

Use of computed tomography-derived body composition to determine the prognosis of patients with primary liver cancer treated with immune checkpoint inhibitors: a retrospective cohort study

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Lu-shan Xiao, Rui-ning Li, Hao Cui, Chang Hong, Chao-yi Huang, Qi-mei Li, Cheng-yi Hu, Zhong-yi Dong, Hong-bo Zhu, Li Liu

HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC

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Jie Mei, Guanyu Jiang, Yundi Chen, Yongrui Xu, Yuan Wan, Ruo Chen, Feng Liu, Wenjun Mao, Mingfeng Zheng, Junying Xu

MRI-based random survival Forest model improves prediction of progression-free survival to induction chemotherapy plus concurrent Chemoradiotherapy in Locoregionally Advanced nasopharyngeal carcinoma

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Wei Pei, Chen Wang, Hai Liao, Xiaobo Chen, Yunyun Wei, Xia Huang, Xueli Liang, Huayan Bao, Danke Su, Guanqiao Jin

Comparative evaluation of somatostatin and CXCR4 receptor expression in different types of thyroid carcinoma using well-characterised monoclonal antibodies

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Max Czajkowski, Daniel Kaemmerer, Jörg Sänger, Guido Sauter, Ralph M. Wirtz, Stefan Schulz, Amelie Lupp

rhG-CSF is associated with an increased risk of metastasis in NSCLC patients following postoperative chemotherapy

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Yong Wang, Chen Fang, Renfang Chen, Shangkun Yuan, Lin Chen, Xiaotong Qiu, Xiaoying Qian, Xinwei Zhang, Zhehao Xiao, Qian Wang, Biqi Fu, Xiaoling Song, Yong Li

Efficacy of donepezil for the treatment of oxaliplatin-induced peripheral neuropathy: DONEPEZOX, a protocol of a proof of concept, randomised, triple-blinded and multicentre trial

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• Study protocol

Nicolas Kerckhove, David Tougeron, Côme Lepage, Denis Pezet, Karine Le Malicot, Manon Pelkowski, Bruno Pereira, David Balayssac

CpG ODN (K3)—toll-like receptor 9 agonist—induces Th1-type immune response and enhances cytotoxic activity in advanced lung cancer patients: a phase I study

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Tomoyuki Otsuka, Sumiyuki Nishida, Takayuki Shibahara, Burcu Temizoz, Masanari Hamaguchi, Takayuki Shiroyama, Keiko Kimura, Kotaro Miyake, Haruhiko Hirata, Yumiko Mizuno, Mayu Yagita, Yusuke Manabe, Etsushi Kuroda, Yoshito Takeda, Hiroshi Kida, Ken J. Ishii, Atsushi Kumanogoh

Oncologic outcomes of single-incision laparoscopic surgery versus conventional laparoscopic surgery for colorectal cancer (CSILS): study protocol for a multicentre, prospective, open-label, noninferiority, randomized controlled trial

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• Study protocol

Zijia Song, Kun Liu, Tao Zhang, Bingshun Wang, Yiqing Shi, Yimei Jiang, Changgang Wang, Xianze Chen, Xiaopin Ji, Ren Zhao

Low expression of PRDM5 predicts poor prognosis of esophageal squamous cell carcinoma

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Jing Guo, Qiuxing Yang, Sheng Wei, Jingjing Shao, Tianye Zhao, Liyuan Guo, Jia Liu, Jia Chen, Gaoren Wang

Circulating tumor cells detected in follow-up predict survival outcomes in tri-modality management of advanced non-metastatic esophageal cancer: a secondary analysis of the QUINTETT randomized trial

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Edward Yu, Alison L. Allan, Michael Sanatani, Debra Lewis, Andrew Warner, A. Rashid Dar, Brian P. Yaremko, Lori E. Lowes, David A. Palma, Jacques Raphael, Mark D. Vincent, George B. Rodrigues, Dalilah Fortin, Richard I. Inculet, Eric Frechette, Joel Bierer, Jeffery Law, Jawaid Younus, Richard A. Malthaner

Improving health-related quality of life in women with breast, blood, and gynaecological Cancer with an eHealth-enabled 12-week lifestyle intervention: the women’s wellness after Cancer program randomised controlled trial

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Charrlotte Seib, Debra Anderson, Amanda McGuire, Janine Porter-Steele, Nicole McDonald, Sarah Balaam, Diksha Sapkota, Alexandra L. McCarthy

Interleukin-8 produced from cancer-associated fibroblasts suppresses proliferation of the OCUCh-LM1 cancer cell line

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Ryota Tanaka, Kenjiro Kimura, Shimpei Eguchi, Go Ohira, Shogo Tanaka, Ryosuke Amano, Hiroaki Tanaka, Masakazu Yashiro, Masaichi Ohira, Shoji Kubo

Combination of midostaurin and ATRA exerts dose-dependent dual effects on acute myeloid leukemia cells with wild type FLT3

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Hao Lu, Xiang-qin Weng, Yan Sheng, Jing Wu, Hui-min Xi, Xun Cai

Prognostic models for outcome prediction in patients with advanced hepatocellular carcinoma treated by systemic therapy: a systematic review and critical appraisal

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Li Li, Xiaomi Li, Wendong Li, Xiaoyan Ding, Yongchao Zhang, Jinglong Chen, Wei Li

Targeting the transcriptional activity of STAT3 by a novel fusion protein

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Yanqiong Chen, Wenting Zhang, Xiufeng Bai, Yi Liu

Discovery of a novel ALK/ROS1/FAK inhibitor, APG-2449, in preclinical non-small cell lung cancer and ovarian cancer models

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Douglas D. Fang, Ran Tao, Guangfeng Wang, Yuanbao Li, Kaixiang Zhang, Chunhua Xu, Guoqin Zhai, Qixin Wang, Jingwen Wang, Chunyang Tang, Ping Min, Dengkun Xiong, Jianyong Chen, Shaomeng Wang, Dajun Yang, Yifan Zhai

Metformin attenuates the production and proliferative effects of prolactin induced by medroxyprogesterone acetate during fertility-sparing treatment for endometrial cancer

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Wenjing Gu, Akira Mitsuhashi, Tatsuya Kobayashi, Makio Shozu

Circulating tumor cells from melanoma patients show phenotypic plasticity and metastatic potential in xenograft NOD.CB17 mice

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Claudia Felici, Francesco Mannavola, Luigia Stefania Stucci, Loren Duda, Paola Cafforio, Camillo Porta, Marco Tucci

Correction: Survival-related indicators ALOX12B and SPRR1A are associated with DNA damage repair and tumor microenvironment status in HPV 16-negative head and neck squamous cell carcinoma patients

• Open Access
• Correction

Jing Li, Ling-Long Tang, Jun Ma

The miR-199a-5p/PD-L1 axis regulates cell proliferation, migration and invasion in follicular thyroid carcinoma

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Jianguang Lin, Yanru Qiu, Xueqin Zheng, Yijun Dai, Tianwen Xu

Retraction Note: Jacarelhyperol A induced apoptosis in leukaemia cancer cell through inhibition the activity of Bcl-2 proteins

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• Retraction Note

Shoude Zhang, Jun Yin, Xia Li, Jigang Zhang, Rongcai Yue, Yanyan Diao, Honglin Li, Hui Wang, Lei Shan, Weidong Zhang

Shikonin derivatives cause apoptosis and cell cycle arrest in human chondrosarcoma cells via death receptors and MAPK regulation

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Birgit Lohberger, Dietmar Glänzer, Heike Kaltenegger, Nicole Eck, Andreas Leithner, Rudolf Bauer, Nadine Kretschmer, Bibiane Steinecker-Frohnwieser

Results of a worldwide external quality assessment of cfDNA testing in lung Cancer

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Jennifer A. Fairley, Melanie H. Cheetham, Simon J. Patton, Etienne Rouleau, Marc Denis, Elisabeth M. C. Dequeker, Ed Schuuring, Kaat van Casteren, Francesca Fenizia, Nicola Normanno, Zandra C. Deans

Soluble POSTN is a novel biomarker complementing CA153 and CEA for breast cancer diagnosis and metastasis prediction

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Li Jia, Guanhua Li, Na Ma, Aimin Zhang, Yunli Zhou, Li Ren, Dong Dong

A potential decision-making algorithm based on endoscopic ultrasound for staging early gastric cancer: a retrospective study

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Yan Yan, Zhonghua Ma, Xin Ji, Jiawei Liu, Ke Ji, Shijie Li, Qi Wu

Real-world data analysis of immune checkpoint inhibitors in stage III-IV adenocarcinoma and squamous cell carcinoma

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Meiling Sun, Huaijun Ji, Ning Xu, Peng Jiang, Tao Qu, Yu Li

Impact of pectoralis muscle loss on cardiac outcome and survival in Cancer patients who received anthracycline based chemotherapy: retrospective study

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Wael Toama, Jason Wiederin, Ryan Shanley, Patricia Jewett, Christina Gu, Chetan Shenoy, Prabhjot S. Nijjar, Anne H. Blaes

Cancer-associated fibroblasts strengthen cell proliferation and EGFR TKIs resistance through aryl hydrocarbon receptor dependent signals in non-small cell lung cancer

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Hao Feng, Boxiong Cao, Xuan Peng, Qiang Wei

Anesthetic propofol enhances cisplatin-sensitivity of non-small cell lung cancer cells through N6-methyladenosine-dependently regulating the miR-486-5p/RAP1-NF-κB axis

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Quan Ling, Shaoyong Wu, Xiaozu Liao, Chiyi Liu, Yong Chen

Retraction Note: Up-regulated miR-199a-5p in gastric cancer functions as an oncogene and targets klotho

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• Retraction Note

Xu-Jun He, Ying-Yu Ma, Sheng Yu, Xiao-Ting Jiang, Yi-Ding Lu, Liang Tao, Hua-Ping Wang, Zhi-Ming Hu, Hou-Quan Tao

Update of a prognostic survival model in head and neck squamous cell carcinoma patients treated with immune checkpoint inhibitors using an expansion cohort

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Majd Issa, Brett G. Klamer, Nikol Mladkova, Georgios I. Laliotis, Vidhya Karivedu, Priyanka Bhateja, Chase Byington, Khaled Dibs, Xueliang Pan, Arnab Chakravarti, John Grecula, Sachin R. Jhawar, Darrion Mitchell, Sujith Baliga, Matthew Old, Ricardo L. Carrau, James W. Rocco, Dukagjin M. Blakaj, Marcelo Bonomi

Prognostic factors associated with 18FDG-PET/CT in esophageal squamous cell carcinoma after trimodality treatment

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Wei-Hsiang Feng, Ying-Yi Chen, Yen‐Shou Kuo, Kuan-Hsun Lin, Yuan-Ming Tsai, Ti-Hui Wu, Hsu-Kai Huang, Tsai-Wang Huang

Public procurement of antineoplastic agents used for treating breast cancer in Brazil between 2013 and 2019

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Ranailla Lima Bandeira dos Santos, Vera Lúcia Edais Pepe, Claudia Garcia Serpa Osorio-de-Castro

The effect of Orem-based self-care education on improving self-care ability of patients undergoing chemotherapy: a randomized clinical trial

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Tayebeh Rakhshani, Siamak Najafi, Fakhry Javady, Alireza Taghian dasht bozorg, Fatemeh Mohammadkhah, Ali Khani Jeihooni

Phase 1 trial of apatinib combined with intensity-modulated radiotherapy in unresectable hepatocellular carcinoma

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Hongzhi Wang, Xianggao Zhu, Yuting Zhao, Dezuo Dong, Lijuan Li, Yong Cai, Yongheng Li, Weihu Wang

Study protocol of a phase II study to evaluate safety and efficacy of neo-adjuvant pembrolizumab and radiotherapy in localized rectal cancer

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• Study protocol

Claudia Corrò, Nicolas C. Buchs, Matthieu Tihy, André Durham-Faivre, Philippe Bichard, Jean-Louis Frossard, Giacomo Puppa, Thomas McKee, Arnaud Roth, Thomas Zilli, Christelle Trembleau, Mariagrazia Di Marco, Valérie Dutoit, Pierre-Yves Dietrich, Frédéric Ris, Thibaud Koessler

Protocol of OGSG 1901: a phase II trial of ramucirumab plus irinotecan for patients with early relapsed gastric cancer during or after adjuvant docetaxel plus S − 1 therapy

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• Study protocol

Toshifumi Yamaguchi, Hisato Kawakami, Daisuke Sakai, Yukinori Kurokawa, Toshio Shimokawa, Masahiro Goto, Taroh Satoh

Randomized trial of surveillance with abbreviated MRI in women with a personal history of breast cancer– impact on patient anxiety and cancer detection

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Marina Mohallem Fonseca, Tasneem Alhassan, Yashmin Nisha, Diana Koszycki, Betty Anne Schwarz, Roanne Segal, Angel Arnaout, Tim Ramsay, Jacqueline Lau, Jean M. Seely

Prognostic impact of pretreatment T790M mutation on outcomes for patients with resected, EGFR-mutated, non-small cell lung cancer

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Yoshiya Matsumoto, Tomoya Kawaguchi, Masaru Watanabe, Shun-ichi Isa, Masahiko Ando, Akihiro Tamiya, Akihito Kubo, Chiyoe Kitagawa, Naoki Yoshimoto, Yasuhiro Koh

The value of HPV genotypes combined with clinical indicators in the classification of cervical squamous cell carcinoma and adenocarcinoma

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Zhimin He, Rongsheng Chen, Shangying Hu, Yajiao Zhang, Yang Liu, Chengwei Li, Fajin Lv, Zhibo Xiao

miR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected cervical cancer cells

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Garima Singh, Sonika Kumari Sharma, Samarendra Kumar Singh

ASIC1α up-regulates MMP-2/9 expression to enhance mobility and proliferation of liver cancer cells via the PI3K/AKT/mTOR pathway

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Yinci Zhang, Jiaojiao Liang, Niandie Cao, Jiafeng Gao, Yinghai Xie, Shuping Zhou, Xiaolong Tang

Biomarker discovery for practice of precision medicine in hypopharyngeal cancer: a theranostic study on response prediction of the key therapeutic agents

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Yumiko Kawata-Shimamura, Hidetaka Eguchi, Reika Kawabata-Iwakawa, Mitsuhiko Nakahira, Yasushi Okazaki, Tetsuya Yoda, Reidar Grénman, Masashi Sugasawa, Masahiko Nishiyama

Transcriptome profiling and co-expression network analysis of lncRNAs and mRNAs in colorectal cancer by RNA sequencing

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Mingjie Li, Dandan Guo, Xijun Chen, Xinxin Lu, Xiaoli Huang, Yan’an Wu

Short-term clinical outcomes of Kyocera Modular Limb Salvage System designed cementless stems for the endoprosthetic reconstruction of lower extremities: a Japanese Musculoskeletal Oncology Group multi-institutional study

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Satoshi Tsukushi, Yoshihiro Nishida, Takeshi Hirose, Eiji Nakata, Rumi Nakagawa, Tomoki Nakamura, Jungo Imanishi, Akihito Nagano, Hironari Tamiya, Takafumi Ueda, Satoshi Tsukushi, Yoshihiro Nishida, Kunihiro Ikuta, Akira Kawai, Takeshi Hirose, Toshiyuki Kunisada, Eiji Nakata, Robert Nakayama, Rumi Nakagawa, Tomoki Nakamura, Tomoaki Torigoe, Jungo Imanishi, Akihito Nagano, Satoshi Takenaka, Hironari Tamiya, Takafumi Ueda, Shigeki Kakunaga, Hirotaka Kawano, Toshiharu Shirai, Ryu Terauchi, Hidetatsu Outani, Shunji Nishimura, Kanya Honoki

Prognostic value of tumor-infiltrating lymphocytes in DCIS: a meta-analysis

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Shuang-Ling Wu, Xinmiao Yu, Xiaoyun Mao, Feng Jin

Geographical variations of cancer incidence in Guadeloupe, French West Indies

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Bernard Bhakkan-Mambir, Jacqueline Deloumeaux, Danièle Luce

Incidence trends of childhood central nervous system tumors in Finland 1990–2017

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Jad Abuhamed, Atte Nikkilä, Jani Raitanen, Wafa Alimam, Olli Lohi, Janne Pitkäniemi, Hannu Haapasalo, Anssi Auvinen

The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC

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Robert Mandic, André Marquardt, Philip Terhorst, Uzma Ali, Annette Nowak-Rossmann, Chengzhong Cai, Fiona R. Rodepeter, Thorsten Stiewe, Bernadette Wezorke, Michael Wanzel, Andreas Neff, Boris A. Stuck, Michael Bette

TTK Protein Kinase promotes temozolomide resistance through inducing autophagy in glioblastoma

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Jian Yu, Ge Gao, Xiangpin Wei, Yang Wang

Prognostic impact of stromal periostin expression in upper urinary tract urothelial carcinoma

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Kosuke Miyai, Kazuki Kawamura, Keiichi Ito, Susumu Matsukuma, Hitoshi Tsuda

The ferroptosis-related long non-coding RNAs signature predicts biochemical recurrence and immune cell infiltration in prostate cancer

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Chunhui Liu, Yue Gao, Jiaxuan Ni, Saisai Chen, Qiang Hu, Can Wang, Mingjin Hu, Ming Chen

Preoperative chemoradiotherapy with capecitabine and triweekly oxaliplatin versus capecitabine monotherapy for locally advanced rectal cancer: a propensity-score matched study

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Anchuan Li, Tingxuan Huang, Rong Zheng, Pan Chi, Zhihua Li, Xiaozhong Wang, Benhua Xu

Tumor specificity of WNT ligands and receptors reveals universal squamous cell carcinoma oncogenes

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Cheng Chen, Lunan Luo, Changling Xu, Xia Yang, Ting Liu, Jingyue Luo, Wen Shi, Lu Yang, Yi Zheng, Jing Yang

An M0 macrophage-related prognostic model for hepatocellular carcinoma

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Yiya Zhang, Ju Zou, Ruochan Chen

Integration of metabolites from meta-analysis with transcriptome reveals enhanced SPHK1 in PDAC with a background of pancreatitis

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Vijayasarathy Ketavarapu, Vishnubhotla Ravikanth, Mitnala Sasikala, G. V. Rao, Ch. Venkataramana Devi, Prabhakar Sripadi, Murali Satyanarayana Bethu, Ramars Amanchy, H. V. V. Murthy, Stephen J. Pandol, D. Nageshwar Reddy

Toripalimab combined with concurrent platinum-based Chemoradiotherapy in patients with locally advanced cervical Cancer: an open-label, single-arm, phase II trial

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• Study protocol

Jie Chen, Chen Li, Yuanjie Cao, Li Zhu, Bailin Zhang, Jinqiang You, Hailing Hou, Jing Wang, Zhiyong Yuan

Life style and interaction with microbiota in prostate cancer patients undergoing radiotherapy: study protocol for a randomized controlled trial

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• Study protocol

Patrizia Gnagnarella, Giulia Marvaso, Barbara Alicja Jereczek-Fossa, Ottavio de Cobelli, Maria Claudia Simoncini, Luiz Felipe Nevola Teixeira, Annarita Sabbatini, Gabriella Pravettoni, Harriet Johansson, Luigi Nezi, Paolo Muto, Valentina Borzillo, Egidio Celentano, Anna Crispo, Monica Pinto, Ernesta Cavalcanti, Sara Gandini, Costanza Gavioli, Silvia Ciceri, Marialetizia Latella, Giulia Corrao, Dario Zerini, Debora Macis, Valentina Aristarco, Gabriele Cozzi, Ketti Mazzocco, Fodor Cristiana Iuliana, Serena Galiè, Carlotta Catozzi, Rossella Di Franco, Nunzio De Martino, Maria Grimaldi, Concetta Montagnese, Melania Prete, Flavia Nocerino, Emanuela Rotondo, Sergio Arpino, Serena Meola, Francesco Labonia, Federica Bellerba

Exercise training and NR supplementation to improve muscle mass and fitness in adolescent and young adult hematopoietic cell transplant survivors: a randomized controlled trial {1}

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Minkeun Song, Saro H. Armenian, Rusha Bhandari, Kyuwan Lee, Kirsten Ness, Mary Putt, Lanie Lindenfeld, Saro Manoukian, Kristin Wade, Anna Dedio, Tati Guzman, Isabella Hampton, Kimberly Lin, Joseph Baur, Shana McCormack, Sogol Mostoufi-Moab

Is RDW a clinically relevant prognostic factor for newly diagnosed multiple myeloma? A systematic review and meta-analysis

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Xiaomin Chen, Jiayue Liu, Jialin Duan, Hao Xiong, Yang Liu, Xinwen Zhang, Chunlan Huang

Racial difference in BMI and lung cancer diagnosis: analysis of the National Lung Screening Trial

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Joy Zhao, Julie A. Barta, Russell McIntire, Christine Shusted, Charnita Zeigler-Johnson, Hee-Soon Juon

RHOA protein expression correlates with clinical features in gastric cancer: a systematic review and meta-analysis

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Seungyoon Nam, Yeeun Lee, Jung Ho Kim

circ_0000045 promotes proliferation, migration, and invasion of head and neck squamous cell carcinomas via regulating HSP70 and MAPK pathway

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Ronghao Sun, Yuqiu Zhou, Yongcong Cai, Chunyan Shui, Xu Wang, Jingqiang Zhu

ArTisaN trial protocol: a single Centre, open-label, phase II trial of the safety and efficacy of TheraSphere selective internal radiation therapy (SIRT) in the treatment of inoperable metastatic (liver) neuroendocrine neoplasia (NENs)

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• Study protocol

Rohini Sharma, Susanna Slater, Joanne Evans, Maria Martinez, Caroline Ward, Hooshang Izadi, Florian Wernig, Rob Thomas

Evaluation of log odds of positive lymph nodes in predicting the survival of patients with non-small cell lung cancer treated with neoadjuvant therapy and surgery: a SEER cohort-based study

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Qing Wang, Suyu Wang, Zhiyong Sun, Min Cao, Xiaojing Zhao

Screening of BRCA1/2 variants in Mauritanian breast cancer patients

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Selma Mohamed Brahim, Ekht Elbenina Zein, Crystel Bonnet, Cheikh Tijani Hamed, Malak Salame, Mohamed Vall Zein, Meriem Khyatti, Ahmedou Tolba, Ahmed Houmeida

A prospective cohort study on the association between waterpipe tobacco smoking and gastric cancer mortality in Northern Vietnam

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Hung Xuan Le, Dung Thi Thuy Truong, Long Bao Tran, Phuoc Hong Le, Binh Uyen Duong Pham, Koji Wada, Shunya Ikeda, Ariuntuul Garidkhuu, Can Van Phan, Ngoan Tran Le

Comprehensive analysis of the prognosis and immune infiltration landscape of RNA methylation-related subtypes in pancreatic cancer

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Siyuan Lu, Jie Hua, Jiang Liu, Miaoyan Wei, Chen Liang, Qingcai Meng, Bo Zhang, Xianjun Yu, Wei Wang, Jin Xu

Cancer risk in persons with new-onset anaemia: a population-based cohort study in Denmark

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Astrid Boennelykke, Henry Jensen, Lene Sofie Granfeldt Østgård, Alina Zalounina Falborg, Anette Tarp Hansen, Kaj Sparle Christensen, Peter Vedsted

Safety and feasibility of neoadjuvant chemotherapy as a surgical bridge for acute left-sided malignant colorectal obstruction: a retrospective study

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Jiawei Zhang, Jiaxin Deng, Jiancong Hu, Qinghua Zhong, Juan Li, Mingli Su, Wei Liu, Miwei Lv, Tian Xu, Dezheng Lin, Xuefeng Guo

Safety and efficacy of irinotecan, oxaliplatin, and capecitabine (XELOXIRI) regimen with or without targeted drugs in patients with metastatic colorectal cancer: a retrospective cohort study

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Xiu Liu, Kai Ou, Xiaoting Ma, Lizhen Gao, Qi Wang, Haizeng Zhang, Lin Yang

Metabolic activity via 18F-FDG PET/CT is predictive of microsatellite instability status in colorectal cancer

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Jinling Song, Zhongwu Li, Lujing Yang, Maomao Wei, Zhi Yang, Xuejuan Wang

Associations of IFT20 and GM130 protein expressions with clinicopathological features and survival of patients with lung adenocarcinoma

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Lianfeng Li, Yaobing Chen, Wei Liao, Qimei Yu, Hui Lin, Yuqin Shi, Ling Zhang, Guoqing Fu, Zhenyu Wang, Xi Li, Xianrong Kong, Ting Zhou, Lingzhi Qin

Metabolic activity determines survival depending on the level of lymph node involvement in cervical cancer

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Alejandra Martinez, Elodie Chantalat, Martina Aida Angeles, Gwénaël Ferron, Anne Ducassou, Manon Daix, Justine Attal, Sarah Bétrian, Amélie Lusque, Erwan Gabiache

Neoadjuvant docetaxel, oxaliplatin and S-1 therapy for the patients with large type 3 or type 4 gastric cancer (OGSG1902): protocol of a multi-center, phase II study

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• Study protocol

Shunji Endo, Tetsuji Terazawa, Masahiro Goto, Ryo Tanaka, Takeshi Kato, Kazumasa Fujitani, Hisato Kawakami, Daisuke Sakai, Yukinori Kurokawa, Toshimasa Tsujinaka, Toshio Shimokawa, Taroh Satoh

Prognostic value of CSN5 in patients with digestive system cancers: a systematic review and meta-analysis

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Yonghua Guo, Meng Gao, Ye Yao, Jinghua Li, Xi Chen, Xingxing Wang, Zhang Chen, Yufeng Yuan, Weijie Ma

Correction: CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma

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• Correction

Yozo Mitsui, Inik Chang, Shinichiro Fukuhara, Miho Hiraki, Naoko Arichi, Hiroaki Yasumoto, Hiroshi Hirata, Soichiro Yamamura, Varahram Shahryari, Guoren Deng, Darryn K. Wong, Shahana Majid, Hiroaki Shiina, Rajvir Dahiya, Yuichiro Tanaka

Nonviral mcDNA-mediated bispecific CAR T cells kill tumor cells in an experimental mouse model of hepatocellular carcinoma

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Hezhi Wang, Xiaoxiao Wang, Xueshuai Ye, Yi Ju, Nana Cao, Shuqi Wang, Jianhui Cai

Impact of renin-angiotensin system inhibitors on the survival of patients with rectal cancer

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Marcin Zeman, Władysław Skałba, Agata Małgorzata Wilk, Alexander Jorge Cortez, Adam Maciejewski, Agnieszka Czarniecka

The Endothelial Activation and Stress Index (EASIX) score is an independent prognostic factor in patients with diffuse large B-cell lymphoma

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Sungwoo Park, Se-Il Go, Gyeong-Won Lee

Glycoprotein α-Subunit of Glucosidase II (GIIα) is a novel prognostic biomarker correlated with unfavorable outcome of urothelial carcinoma

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Qiongqiong Lin, Lu Pei, Zhiguang Zhao, Xiaoping Zhuang, Haide Qin

Genomic signature of MTOR could be an immunogenicity marker in human colorectal cancer

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Chenxing Wang, Batuer Aikemu, Yanfei Shao, Sen Zhang, Guang Yang, Hiju Hong, Ling Huang, Hongtao Jia, Xiao Yang, Minhua Zheng, Jing Sun, Jianwen Li

Patient, primary care provider, and stakeholder perspectives on mammography screening frequency: lessons learned from a qualitative study

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Vicky Ro, Tarsha Jones, Thomas Silverman, Julia E. McGuinness, Ashlee Guzman, Jacquelyn Amenta, Rita Kukafka, Katherine D. Crew

Study protocol of the FIRE-8 (AIO-KRK/YMO-0519) trial: a prospective, randomized, open-label, multicenter phase II trial investigating the efficacy of trifluridine/tipiracil plus panitumumab versus trifluridine/tipiracil plus bevacizumab as first-line treatment in patients with metastatic colorectal cancer

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• Study protocol

G. Sommerhäuser, A. Kurreck, S. Stintzing, V. Heinemann, L. Fischer von Weikersthal, T. Dechow, F. Kaiser, M. Karthaus, I. Schwaner, M. Fuchs, A. König, C. Roderburg, I. Hoyer, M. Quante, A. Kiani, S. Fruehauf, L. Müller, A. Reinacher-Schick, T. J. Ettrich, A. Stahler, D. P. Modest

Correction: Repurposing mechanistic insight of PDE-5 inhibitor in cancer chemoprevention through mitochondrial-oxidative stress intervention and blockade of DuCLOX signalling

• Open Access
• Correction

Manjari Singh, Sweta Kasna, Subhadeep Roy, Sara Aldosary, Abdulaziz S. Saeedan, Mohd. Nazam Ansari, Gaurav Kaithwas

Correction: Exploring the potential mechanism of emetine against coronavirus disease 2019 combined with lung adenocarcinoma: bioinformatics and molecular simulation analyses

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• Correction

Kun Zhang, Ke Wang, Chaoguo Zhang, Xiuli Teng, Dan Li, Mingwei Chen

Association between c-type lectin-like receptor 2 and microsatellite instability in colorectal cancer: a cross-sectional study

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Xin Zhang, Jia-rui Yuan, Xin Wang, Shuang Fu, Rui-tao Wang, Guang-yu Wang

Body mass index and serum markers associated with progression-free survival in lung cancer patients treated with immune checkpoint inhibitors

• Open Access
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Zhenzhen Liu, Yuzhu Diao, Xiaoling Li

Correction: Integration of metabolites from meta-analysis with transcriptome reveals enhanced SPHK1 in PDAC with a background of pancreatitis

• Open Access
• Correction

Vijayasarathy Ketavarapu, Vishnubhotla Ravikanth, Mitnala Sasikala, G. V. Rao, Ch. Venkataramana Devi, Prabhakar Sripadi, Murali Satyanarayana Bethu, Ramars Amanchy, H. V. V. Murthy, Stephen J. Pandol, D. Nageshwar Reddy

Burden, trends, and risk factors for breast cancer in China from 1990 to 2019 and its predictions until 2034: an up-to-date overview and comparison with those in Japan and South Korea

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Na Liu, Da-Wei Yang, Yan-Xia Wu, Wen-Qiong Xue, Dan-Hua Li, Jiang-Bo Zhang, Yong-Qiao He, Wei-Hua Jia

A phase II open label, single arm study of hypofractionated stereotactic radiotherapy with chemoradiotherapy using intensity-modulated radiotherapy for newly diagnosed glioblastoma after surgery: the HSCK-010 trial protocol

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• Study protocol

Yun Guan, Mingyuan Pan, Jun Yang, Qiuxia Lu, Liangfu Han, Ying Liu, Jing Li, Huaguang Zhu, Xiu Gong, Guanghai Mei, Xiaoxia Liu, Li Pan, Jiazhong Dai, Yang Wang, Enmin Wang, Xin Wang

Genome-wide DNA methylation signature predict clinical benefit of bevacizumab in non-small cell lung cancer

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Butuo Li, Chao Jiang, Yiyue Xu, Xinyu Fan, Linlin Yang, Bing Zou, Bingjie Fan, Linlin Wang

Carboplatin dose calculations for patients with lung cancer: significant dose differences found depending on dosing equation choice

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Seçkin Akgül, Bryan A. Chan, Peter M. Manders

Four-gene signature predicting overall survival and immune infiltration in hepatocellular carcinoma by bioinformatics analysis with RT‒qPCR validation

• Open Access
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Renguo Guan, Jingwen Zou, Jie Mei, Min Deng, Rongping Guo

HE4 as a serum biomarker for the diagnosis of pelvic masses: a prospective, multicenter study in 965 patients

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Elena Ioana Braicu, Catherine Linn Krause, Uwe Torsten, Herbert Mecke, Rolf Richter, Lars Hellmeyer, Malgorzata Lanowska, Bodo Müller, Elisa Koch, Janine Boenneß-Zaloum, Kerstin Ames, Radoslav Chekerov, Kati Hasenbein, Mathias Zimmermann, Mandy Mangler, Frank Chen, Rudolf Tauber, Jalid Sehouli

Video-assisted thoracoscopic treatment as two-day surgery for lung neoplasms: a propensity-matched analysis

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Guofei Zhang, Junqiang Fan, Zipu Yu, Ying Chai, Sai Zhang, Ming Wu, Gang Shen

Blockade of the amino acid transporter SLC6A14 suppresses tumor growth in colorectal Cancer

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Ying Lu, Ziting Jiang, Kaijing Wang, Shanshan Yu, Chongbo Hao, Zuan Ma, Xuelian Fu, Ming Qing Qin, Zengguang Xu, Lieying Fan

Cancer-testis antigen KK-LC-1 is a potential biomarker associated with immune cell infiltration in lung adenocarcinoma

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Yanli Kang, Yuhan Gan, Yingfeng Jiang, Jianbin You, Chen Huang, Qianshun Chen, Xunyu Xu, Falin Chen, Liangyuan Chen

An integrative transcriptome analysis reveals potential predictive, prognostic biomarkers and therapeutic targets in colorectal cancer

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Pouria Samadi, Meysam Soleimani, Fatemeh Nouri, Fatemeh Rahbarizadeh, Rezvan Najafi, Akram Jalali

Changing trends in the disease burden of non-melanoma skin cancer globally from 1990 to 2019 and its predicted level in 25 years

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Wan Hu, Lanlan Fang, Ruyu Ni, Hengchuan Zhang, Guixia Pan

Factors associated with initiation and continuation of endocrine therapy in women with hormone receptor-positive breast cancer

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Beomyoung Cho, Maria Pérez, Donna B. Jeffe, Matthew W. Kreuter, Julie A. Margenthaler, Graham A. Colditz, Ying Liu

Vitamin D intake and gastric cancer in Viet Nam: a case-control study

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Minh Thien Nguyen, Nhi Ngoc Yen Huynh, Dai Duc Nguyen, Nguyen Ha Ta, Tai Van Nguyen, Huy Thanh Dang, Ngoan Tran Le

C-reactive protein/albumin ratio and Glasgow prognostic score are associated with prognosis and infiltration of Foxp3+ or CD3+ lymphocytes in colorectal liver metastasis

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Hiroki Kanno, Toru Hisaka, Jun Akiba, Kazuaki Hashimoto, Fumihiko Fujita, Yoshito Akagi

Bias and inconsistency in the estimation of tumour mutation burden

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Mohammad A. Makrooni, Brian O’Sullivan, Cathal Seoighe

Risk factors for rebleeding and long-term outcomes in patients with head and neck cancer bleeding: a multicenter study

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Chih-Kai Wang, Che-Fang Ho, Kuang-Yu Niu, Chia-Chien Wu, Yun-Chen Chang, Chien-Han Hsiao, Chieh-Ching Yen

Germline variants profiling of BRCA1 and BRCA2 in Chinese Hakka breast and ovarian cancer patients

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Yunuo Zhang, Heming Wu, Zhikang Yu, Liang Li, Jinhong Zhang, Xinhong Liang, Qingyan Huang

A role for ceruloplasmin in the control of human glioblastoma cell responses to radiation

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Charlotte Roy, Sylvie Avril, Claire Legendre, Bénédicte Lelièvre, Honorine Vellenriter, Sébastien Boni, Jérôme Cayon, Catherine Guillet, Yannick Guilloux, Michel Chérel, François Hindré, Emmanuel Garcion

Characterization and comparison of human glioblastoma models

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Julia A. Schulz, Louis T. Rodgers, Richard J. Kryscio, Anika M.S. Hartz, Björn Bauer

Inhibition of hyperprogressive cancer disease induced by immune-checkpoint blockade upon co-treatment with meta-tyrosine and p38 pathway inhibitor

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Daniela R. Montagna, Alejandra Duarte, Paula Chiarella, Bárbara Rearte, Oscar D. Bustuoabad, Mónica Vermeulen, Raúl A. Ruggiero

Preoperative hypokalemia can increase complications after colorectal cancer surgery: a propensity score matching analysis

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Bin Zhang, Xiao-Yu Liu, Bing Kang, Chao Yuan, Zi-Wei Li, Zheng-Qiang Wei, Dong Peng

Survival of cancer patients with pre-existing heart disease

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Ciaran O’Neill, David W. Donnelly, Mark Harbinson, Therese Kearney, Colin R. Fox, Gerard Walls, Anna Gavin

Expression of PD1 and PDL1 as immune-checkpoint inhibitors in mantle cell lymphoma

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Fereshteh Ameli, Elham Shajareh, Maral Mokhtari, Farid Kosari

Female breast cancer incidence predisposing risk factors identification using nationwide big data: a matched nested case-control study in Taiwan

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Ping-Hung Liu, James Cheng-Chung Wei, Yu-Hsun Wang, Ming-Hsin Yeh

Impact of the COVID-19 pandemic on emergency hospital cancer admissions in a UK region

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• COVID-19
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Helen Mitchell, Ben S. Alford, Simon O’Hare, Eamon O’Callaghan, Colin Fox, Anna T. Gavin

Neoadjuvant nivolumab + T-VEC combination therapy for resectable early stage or metastatic (IIIB-IVM1a) melanoma with injectable disease: study protocol of the NIVEC trial

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• Study protocol

Maartje W. Rohaan, Emma H. A. Stahlie, Viola Franke, Lisanne P. Zijlker, Sofie Wilgenhof, Vincent van der Noort, Alexander C. J. van Akkooi, John B. A. G. Haanen

The acidic tumor microenvironment enhances PD-L1 expression via activation of STAT3 in MDA-MB-231 breast cancer cells

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Yong-Jin Kwon, Eun-Bi Seo, Ae Jin Jeong, Song-Hee Lee, Kum Hee Noh, Sangsik Lee, Chung-Hyun Cho, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Hyeong-Gon Moon, Sang-Kyu Ye

Association between metabolic syndrome, C-reactive protein, and the risk of primary liver cancer: a large prospective study

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Mengmeng Song, Tong Liu, Hai Liu, Qi Zhang, Qingsong Zhang, Yiming Wang, Xiangming Ma, Liying Cao, Hanping Shi

High prevalence of and factors associated with human papillomavirus infection among women attending a tertiary hospital in Gauteng Province, South Africa

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Teboho Amelia Tiiti, Selokela Gloria Selabe, Johannes Bogers, Ramokone Lisbeth Lebelo

The clinicopathological and prognostic significances of IGF-1R and Livin expression in patients with colorectal cancer

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Zhenling Zhang, Yuxin Zhang, Si Lao, Jian Qiu, Ziang Pan, Xiaoying Feng

Differential diagnosis and prognosis of small renal masses: association with collateral vessels detected using contrast-enhanced computed tomography

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Masato Yanagi, Tomonari Kiriyama, Jun Akatsuka, Yuki Endo, Hayato Takeda, Akifumi Katsu, Yuichiro Honda, Kyota Suzuki, Yoshihiro Nishikawa, Shunsuke Ikuma, Hikaru Mikami, Yuka Toyama, Go Kimura, Yukihiro Kondo

High-throughput circular RNA sequencing reveals the profiles of circular RNA in non-cirrhotic hepatocellular carcinoma

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Hongyu Li, Liangliang Xu, Pengsheng Yi, Lian Li, Tao Yan, Liang Xie, Zhijun Zhu

Prognostic value of systemic inflammation response index in nasopharyngeal carcinoma with negative Epstein-Barr virus DNA

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Xiaofei Yuan, Hua Yang, Fangfang Zeng, Shiyu Zhou, Shuting Wu, Yue Yuan, Linchong Cui, Huiru Feng, Danfan Lin, Zilu Chen, Xiong Liu, Jing Chen, Fan Wang

Poor treatment responses were related to poor outcomes in pediatric B cell acute lymphoblastic leukemia with KMT2A rearrangements

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Jinquan Wen, Min Zhou, Yali Shen, Yueting long, Yuxia Guo, Lin Song, Jianwen Xiao

Serum 25-hydroxyvitamin D and cancer-related fatigue: associations and effects on depression, anxiety, functional capacity and health-related quality of Life in breast cancer survivors during adjuvant endocrine therapy

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Isis Danyelle Dias Custódio, Fernanda Silva Mazzutti Nunes, Mariana Tavares Miranda Lima, Kamila Pires de Carvalho, Débora Santana Alves, Juliana Freitas Chiaretto, Paula Philbert Lajolo Canto, Carlos Eduardo Paiva, Yara Cristina de Paiva Maia

Composite scoring system and optimal tumor budding cut-off number for estimating lymph node metastasis in submucosal colorectal cancer

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Jeong-ki Kim, Ye-Young Rhee, Jeong Mo Bae, Jung Ho Kim, Seong-Joon Koh, Hyun Jung Lee, Jong Pil Im, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park, Ji Won Park, Gyeong Hoon Kang

Systematic review of circulating MICRORNAS as biomarkers of cervical carcinogenesis

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Neila Pierote Gaspar Nascimento, Thais Borges Gally, Grasiely Faccin Borges, Luciene Cristina Gastalho Campos, Carla Martins Kaneto

Impact of adjuvant chemotherapy on T1N0M0 breast cancer patients: a propensity score matching study based on SEER database and external cohort

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Kaiwen Shen, Longdi Yao, Jingyuan Zhu, Ximing Gu, Jie Wang, Wei Qian, Zhijian Zheng, Deyuan Fu, Song Wu

LAP3 contributes to IFN-γ-induced arginine depletion and malignant transformation of bovine mammary epithelial cells

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Li Li, Fengyang Li, Xiuhong Hu, Zengshuai Wu, Wenbo Ren, Tingting Wang, Zhengchao Ji, Na Li, Jingmin Gu, Changjiang Sun, Xin Feng, Wenyu Han, Jing Huang, Liancheng Lei

Adjuvant therapy with gemcitabine and stereotactic body radiation therapy versus gemcitabine alone for resected stage II pancreatic cancer: a prospective, randomized, open-label, single center trial

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Tao Ma, Xueli Bai, Qichun Wei, Yongjie Shui, Mengyi Lao, Wen Chen, Bingfeng Huang, Risheng Que, Shunliang Gao, Yun Zhang, Wei Chen, Ji Wang, Tingbo Liang

DNA damage repair gene signature model for predicting prognosis and chemotherapy outcomes in lung squamous cell carcinoma

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Xinshu Wang, Zhiyuan Huang, Lei Li, Guangxue Wang, Lin Dong, Qinchuan Li, Jian Yuan, Yunhui Li

M6A-related lncRNAs predict clinical outcome and regulate the tumor immune microenvironment in hepatocellular carcinoma

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Bo Chen, Zhan Yang, Zhichao Lang, Qiqi Tao, Rongrong Zhang, Yating Zhan, Xuantong Xu, Kai Zhu, Jianjian Zheng, Zhengping Yu, Suhui Yu

Predictive value of proteomic markers for advanced rectal cancer with neoadjuvant chemoradiotherapy

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Hanyang Wang, Dengbo Ji, Huifang Tian, Zhaoya Gao, Can Song, Jinying Jia, Xinxin Cui, Lijun Zhong, Jing Shen, Jin Gu

A multicenter investigator-initiated Phase 2 trial of E7090 in patients with advanced or recurrent solid tumor with fibroblast growth factor receptor (FGFR) gene alteration: FORTUNE trial

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Yohei Chiba, Kazuki Sudo, Yuki Kojima, Hitomi Okuma, Shinji Kohsaka, Ryunosuke Machida, Masahiko Ichimura, Kenta Anjo, Kazumi Kurishita, Natsuko Okita, Kenichi Nakamura, Ichiro Kinoshita, Masanobu Takahashi, Junichi Matsubara, Hitoshi Kusaba, Kan Yonemori, Masamichi Takahashi

Sodium selenite inhibits proliferation and metastasis through ROS‐mediated NF‐κB signaling in renal cell carcinoma

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Xiao Liu, Meng Jiang, Chenggang Pang, Jianning Wang, Lijuan Hu

Expression characteristic, immune signature, and prognosis value of EFNA family identified by multi-omics integrative analysis in pan-cancer

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Zonglin Jiao, Xiao Feng, Yuqing Cui, Lei Wang, Junqing Gan, Yanbin Zhao, Qingwei Meng

Development and validation of a clinicoradiomic nomogram to assess the HER2 status of patients with invasive ductal carcinoma

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Aqiao Xu, Xiufeng Chu, Shengjian Zhang, Jing Zheng, Dabao Shi, Shasha Lv, Feng Li, Xiaobo Weng

Lycorine inhibits angiogenesis by docking to PDGFRα

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Fei Lv, XiaoQi Li, Ying Wang

Evaluation of the role of KPNA2 mutations in breast cancer prognosis using bioinformatics datasets

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Layla Alnoumas, Lisa van den Driest, Zoe Apczynski, Alison Lannigan, Caroline H. Johnson, Nicholas J. W. Rattray, Zahra Rattray

The prognostic impact of lung adenocarcinoma predominance classification relating to pathological factors in lobectomy, the Japanese Joint Committee of Lung Cancer Registry Database in 2010

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Hiroyuki Ito, Hiroshi Date, Yasushi Shintani, Etsuo Miyaoka, Ryoichi Nakanishi, Mitsutaka Kadokura, Shunsuke Endo, Masayuki Chida, Ichiro Yoshino, Hidemi Suzuki

MiR-26a-5p regulates proliferation, apoptosis, migration and invasion via inhibiting hydroxysteroid dehydrogenase like-2 in cervical cancer cell

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Ming Li, Yubo Xiao, Minqi Liu, Qian Ning, Ziye Xiang, Xiang Zheng, Shengsong Tang, Zhongcheng Mo

Inflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study

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Emma Fontvieille, Mathilde His, Carine Biessy, Anne-Sophie Navionis, Gabriela Torres-Mejía, Angélica Ángeles-Llerenas, Isabel Alvarado-Cabrero, Gloria Inés Sánchez, Edgar Navarro, Yorlany Rodas Cortes, Carolina Porras, Ana Cecilia Rodriguez, Maria Luisa Garmendia, José Luis Soto, Leonor Moyano, Peggy L. Porter, Ming Gang Lin, Jamie Guenthoer, Isabelle Romieu, Sabina Rinaldi, Jenny Tejeda, María Felix Lazcano, Libia Zulema Franco, Roberto Jaramillo, Alberto Angel, Carlos Andres Ossa, William H. Arias, Gabriel Bedoya, Alicia Cock-Rada, Carolina Echeverri, Fernando Herazo, Israel Díaz-Yunez, Angel Hernández, Bernal Cortes, Paula Gonzalez, Rebecca Ocampo, Diego Guillen, Viviana Loría, Catalina Vial, Lizette Diaz, Elizabeth Donato, Thomas Donn, Kelly Wirtala, Hailey Loucks

Assessing the impact of MRI based diagnostics on pre-treatment disease classification and prognostic model performance in men diagnosed with new prostate cancer from an unscreened population

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Artitaya Lophatananon, Matthew H. V. Byrne, Tristan Barrett, Anne Warren, Kenneth Muir, Ibifuro Dokubo, Fanos Georgiades, Mostafa Sheba, Lisa Bibby, Vincent J. Gnanapragasam

Construction of immune-related signature and identification of S100A14 determining immune-suppressive microenvironment in pancreatic cancer

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Chengcheng Wang, Yuan Chen, Yin Xinpeng, Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Qiang Xu, Yupei Zhao

Prognostic significance of AKR1C4 and the advantage of combining EBV DNA to stratify patients at high risk of locoregional recurrence of nasopharyngeal carcinoma

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