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BMC Medicine

Ausgabe 1/2013

Inhalt (263 Artikel)

Open Access Question and Answer

Video Q&A: Excess body weight and cancer

Rudolf Kaaks

Open Access Guideline

RAMESES publication standards: meta-narrative reviews

Geoff Wong, Trish Greenhalgh, Gill Westhorp, Jeanette Buckingham, Ray Pawson

Open Access Guideline

RAMESES publication standards: realist syntheses

Geoff Wong, Trish Greenhalgh, Gill Westhorp, Jeanette Buckingham, Ray Pawson

Open Access Research article

Plasminogen activator inhibitor-1 4G/5G polymorphism and retinopathy risk in type 2 diabetes: a meta-analysis

Tengyue Zhang, Chong Pang, Ningdong Li, Elaine Zhou, Kanxing Zhao

Open Access Review

Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases

Michela Flego, Alessandro Ascione, Maurizio Cianfriglia, Stefano Vella

Open Access Research article

Support of personalized medicine through risk-stratified treatment recommendations - an environmental scan of clinical practice guidelines

Tsung Yu, Daniela Vollenweider, Ravi Varadhan, Tianjing Li, Cynthia Boyd, Milo A Puhan

Open Access Research article

How well do clinical prediction rules perform in identifying serious infections in acutely ill children across an international network of ambulatory care datasets?

Jan Y Verbakel, Ann Van den Bruel, Matthew Thompson, Richard Stevens, Bert Aertgeerts, Rianne Oostenbrink, Henriette A Moll, Marjolein Y Berger, Monica Lakhanpaul, David Mant, Frank Buntinx

Open Access Review

Recent advances in the diagnosis and treatment of bladder cancer

Grace Cheung, Arun Sahai, Michele Billia, Prokar Dasgupta, Muhammad S Khan

Open Access Opinion

Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3?

Michel de Lorgeril, Patricia Salen, Pascal Defaye, Mikael Rabaeus

Open Access Minireview

Genetics of scleroderma: implications for personalized medicine?

Shervin Assassi, Timothy RDJ Radstake, Maureen D Mayes, Javier Martin

Open Access Opinion

The young osteoarthritic knee: dilemmas in management

Paul M Sutton, Edward S Holloway

Open Access Research article

Collectives of diagnostic biomarkers identify high-risk subpopulations of hematuria patients: exploiting heterogeneity in large-scale biomarker data

Frank Emmert-Streib, Funso Abogunrin, Ricardo de Matos Simoes, Brian Duggan, Mark W Ruddock, Cherith N Reid, Owen Roddy, Lisa White, Hugh F O'Kane, Declan O'Rourke, Neil H Anderson, Thiagarajan Nambirajan, Kate E Williamson

Open Access Opinion

Diet, a new target to prevent depression?

Almudena Sanchez-Villegas, Miguel A Martínez-González

Open Access Research article

Meta-analysis: implications of interleukin-28B polymorphisms in spontaneous and treatment-related clearance for patients with hepatitis C

María A Jiménez-Sousa, Amanda Fernández-Rodríguez, María Guzmán-Fulgencio, Mónica García-Álvarez, Salvador Resino

Open Access Correspondence

Economic analyses to support decisions about HPV vaccination in low- and middle-income countries: a consensus report and guide for analysts

Mark Jit, Carol Levin, Marc Brisson, Ann Levin, Stephen Resch, Johannes Berkhof, Jane Kim, Raymond Hutubessy

Open Access Minireview

Epigenetic mechanisms in migraine: a promising avenue?

Else Eising, Nicole A Datson, Arn MJM van den Maagdenberg, Michel D Ferrari

Open Access Research article

Paternal obesity is associated with IGF2hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort

Adelheid Soubry, Joellen M Schildkraut, Amy Murtha, Frances Wang, Zhiqing Huang, Autumn Bernal, Joanne Kurtzberg, Randy L Jirtle, Susan K Murphy, Cathrine Hoyo

Open Access Commentary

Fat dads must not be blamed for their children's health problems

Gudrun E Moore, Philip Stanier

Open Access Commentary

Smoking and HIV: time for a change?

Nicola Petrosillo, Stefania Cicalini

Open Access Research article

Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition

Sabine Rohrmann, Kim Overvad, H Bas Bueno-de-Mesquita, Marianne U Jakobsen, Rikke Egeberg, Anne Tjønneland, Laura Nailler, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Vittorio Krogh, Domenico Palli, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Manuela M Bergmann, Heiner Boeing, Kuanrong Li, Rudolf Kaaks, Kay-Tee Khaw, Nicholas J Wareham, Francesca L Crowe, Timothy J Key, Androniki Naska, Antonia Trichopoulou, Dimitirios Trichopoulos, Max Leenders, Petra HM Peeters, Dagrun Engeset, Christine L Parr, Guri Skeie, Paula Jakszyn, María-José Sánchez, José M Huerta, M Luisa Redondo, Aurelio Barricarte, Pilar Amiano, Isabel Drake, Emily Sonestedt, Göran Hallmans, Ingegerd Johansson, Veronika Fedirko, Isabelle Romieux, Pietro Ferrari, Teresa Norat, Anne C Vergnaud, Elio Riboli, Jakob Linseisen

Open Access Research article

A bibliometric analysis of childhood immunization research productivity in Africa since the onset of the Expanded Program on Immunization in 1974

Charles S Wiysonge, Olalekan A Uthman, Peter M Ndumbe, Gregory D Hussey

Open Access Commentary

Causes of death after fluid bolus resuscitation: new insights from FEAST

John Myburgh, Simon Finfer

Open Access Research article

Exploring mechanisms of excess mortality with early fluid resuscitation: insightsfrom the FEAST trial

Kathryn Maitland, Elizabeth C George, Jennifer A Evans, Sarah Kiguli, Peter Olupot-Olupot, Samuel O Akech, Robert O Opoka, Charles Engoru, Richard Nyeko, George Mtove, Hugh Reyburn, Bernadette Brent, Julius Nteziyaremye, Ayub Mpoya, Natalie Prevatt, Cornelius M Dambisya, Daniel Semakula, Ahmed Ddungu, Vicent Okuuny, Ronald Wokulira, Molline Timbwa, Benedict Otii, Michael Levin, Jane Crawley, Abdel G Babiker, Diana M Gibb

Open Access Research article

Systematic review and meta-analysis: influence of smoking cessation on incidence of pneumonia in HIV

Preeti De, Amanda Farley, Nicola Lindson, Paul Aveyard

Open Access Research article

Actigraphy assessments of circadian sleep-wake cycles in the Vegetative and Minimally Conscious States

Damian Cruse, Aurore Thibaut, Athena Demertzi, Julia C Nantes, Marie-Aurélie Bruno, Olivia Gosseries, Audrey Vanhaudenhuyse, Tristan A Bekinschtein, Adrian M Owen, Steven Laureys

Open Access Research article

The global burden of neonatal hypothermia: systematic review of a major challenge for newborn survival

Karsten Lunze, David E Bloom, Dean T Jamison, Davidson H Hamer

Open Access Research article

Genetic discrimination and life insurance: a systematic review of the evidence

Yann Joly, Ida Ngueng Feze, Jacques Simard

Open Access Review

Depression pathogenesis and treatment: what can we learn from blood mRNA expression?

Nilay Hepgul, Annamaria Cattaneo, Patricia A Zunszain, Carmine M Pariante

Open Access Research article

The effects of apoptosis vulnerability markers on the myocardium in depression after myocardial infarction

Yiming Wang, Xingde Liu, Dongfeng Zhang, Jianhui Chen, Shuzheng Liu, Michael Berk

Open Access Research article

Duration of lithium treatment is a risk factor for reduced glomerular function: a cross-sectional study

Alberto Bocchetta, Raffaella Ardau, Paolo Carta, Franca Ligas, Claudia Sardu, Antonello Pani, Maria Del Zompo

Open Access Commentary

A practical method to target individuals for outbreak detection and control

Gerardo Chowell, Cécile Viboud

Open Access Research article

Promoting networks between evidence-based medicine and values-based medicine in continuing medical education

Myriam M Altamirano-Bustamante, Nelly F Altamirano-Bustamante, Alberto Lifshitz, Ignacio Mora-Magaña, Adalberto de Hoyos, María Teresa Ávila-Osorio, Silvia Quintana-Vargas, Jorge A Aguirre, Jorge Méndez, Chiharu Murata, Rodrigo Nava-Diosdado, Oscar Martínez-González, Elisa Calleja, Raúl Vargas, Juan Manuel Mejía-Arangure, Araceli Cortez-Domínguez, Fernand Vedrenne-Gutiérrez, Perla Sueiras, Juan Garduño, Sergio Islas-Andrade, Fabio Salamanca, Jesús Kumate-Rodríguez, Alejandro Reyes-Fuentes

Open Access Research article

Maternal caffeine intake during pregnancy is associated with birth weight but not with gestational length: results from a large prospective observational cohort study

Verena Sengpiel, Elisabeth Elind, Jonas Bacelis, Staffan Nilsson, Jakob Grove, Ronny Myhre, Margaretha Haugen, Helle Margrete Meltzer, Jan Alexander, Bo Jacobsson, Anne-Lise Brantsæter

Open Access Research article

Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial

Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, James F List

Open Access Guideline

Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement

Don Husereau, Michael Drummond, Stavros Petrou, Chris Carswell, David Moher, Dan Greenberg, Federico Augustovski, Andrew H Briggs, Josephine Mauskopf, Elizabeth Loder

Open Access Review

Biologic therapy for autoimmune diseases: an update

Ziv Rosman, Yehuda Shoenfeld, Gisele Zandman-Goddard

Open Access Research article

The thrombophilic network of autoantibodies in celiac disease

Aaron Lerner, Nancy Agmon-Levin, Yinon Shapira, Boris Gilburd, Sandra Reuter, Idit Lavi, Yehuda Shoenfeld

Open Access Research article

16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus

Shaye Kivity, Aviva Katzav, Maria Teresa Arango, Moran Landau-Rabi, Yaron Zafrir, Nancy Agmon-Levin, Miri Blank, Juan-Manuel Anaya, Edna Mozes, Joab Chapman, Yehuda Shoenfeld

Open Access Commentary

Discoveries in the pathophysiology of neuropsychiatric lupus erythematosus: consequences for therapy

Takahisa Gono, Yasushi Kawaguchi, Hisashi Yamanaka

Open Access Research article

Coagulopathy triggered autoimmunity: experimental antiphospholipid syndrome in factor V Leiden mice

Aviva Katzav, Nikolaos C Grigoriadis, Tania Ebert, Olga Touloumi, Miri Blank, Chaim G Pick, Yehuda Shoenfeld, Joab Chapman

Open Access Review

Novel aspects of Sjögren’s syndrome in 2012

Angela Tincani, Laura Andreoli, Ilaria Cavazzana, Andrea Doria, Marta Favero, Maria-Giulia Fenini, Franco Franceschini, Andrea Lojacono, Giuseppe Nascimbeni, Amerigo Santoro, Francesco Semeraro, Paola Toniati, Yehuda Shoenfeld

Open Access Commentary

Age-related autoimmunity

Zahava Vadasz, Tharwat Haj, Aharon Kessel, Elias Toubi

Open Access Review

Renal involvement in autoimmune connective tissue diseases

Andreas Kronbichler, Gert Mayer

Open Access Review

Phosphodiesterase 4-targeted treatments for autoimmune diseases

Neal Kumar, Ari M Goldminz, Noori Kim, Alice B Gottlieb

Open Access Research article

Associations between selected immune-mediated diseases and tuberculosis: record-linkage studies

Sreeram V Ramagopalan, Raph Goldacre, Andrew Skingsley, Chris Conlon, Michael J Goldacre

Open Access Research article

Anti-ribosomal P protein IgG autoantibodies in patients with systemic lupus erythematosus: diagnostic performance and clinical profile

Diana Carmona-Fernandes, Maria José Santos, Helena Canhão, João Eurico Fonseca

Open Access Research article

Slow CCL2-dependent translocation of biopersistent particles from muscle to brain

Zakir Khan, Christophe Combadière, François-Jérôme Authier, Valérie Itier, François Lux, Christopher Exley, Meriem Mahrouf-Yorgov, Xavier Decrouy, Philippe Moretto, Olivier Tillement, Romain K Gherardi, Josette Cadusseau

Open Access Review

Requirements for innate immune pathways in environmentally induced autoimmunity

Kenneth Michael Pollard, Dwight H Kono

Open Access Technical advance

Quantifiable diagnosis of muscular dystrophies and neurogenic atrophies through network analysis

Aurora Sáez, Eloy Rivas, Adoración Montero-Sánchez, Carmen Paradas, Begoña Acha, Alberto Pascual, Carmen Serrano, Luis M Escudero

Open Access Review

Hypersomnia and depressive symptoms: methodological and clinical aspects

Yves Dauvilliers, Régis Lopez, Maurice Ohayon, Sophie Bayard

Open Access Research article

Impact of diuretic therapy-associated electrolyte disorders present on admission to the emergency department: a cross-sectional analysis

Spyridon Arampatzis, Georg-Christian Funk, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Christoph Schwarz, Heinz Zimmermann, Aristomenis Konstantinos Exadaktylos, Gregor Lindner

Open Access Research article

Reporting of analyses from randomized controlled trials with multiple arms: a systematic review

Gabriel Baron, Elodie Perrodeau, Isabelle Boutron, Philippe Ravaud

Open Access Review

Novel approaches to minimize ventilator-induced lung injury

Eddy Fan, Jesus Villar, Arthur S Slutsky

Open Access Research article

High-end normal adrenocorticotropic hormone and cortisol levels are associated with specific cardiovascular risk factors in pediatric obesity: a cross-sectional study

Flavia Prodam, Roberta Ricotti, Valentina Agarla, Silvia Parlamento, Giulia Genoni, Caterina Balossini, Gillian Elisabeth Walker, Gianluca Aimaretti, Gianni Bona, Simonetta Bellone

Open Access Research article

Shifting from glucose diagnosis to the new HbA1c diagnosis reduces the capability of the Finnish Diabetes Risk Score (FINDRISC) to screen for glucose abnormalities within a real-life primary healthcare preventive strategy

Bernardo Costa, Francisco Barrio, Josep L Piñol, Joan J Cabré, Xavier Mundet, Ramon Sagarra, Jordi Salas-Salvadó, Oriol Solà-Morales

Open Access Research article

Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study

Mora Murri, Isabel Leiva, Juan Miguel Gomez-Zumaquero, Francisco J Tinahones, Fernando Cardona, Federico Soriguer, María Isabel Queipo-Ortuño

Open Access Research article

Combined impact of traditional and non-traditional health behaviors on mortality: a national prospective cohort study in Spanish older adults

David Martínez-Gómez, Pilar Guallar-Castillón, Luz M León-Muñoz, Esther López-García, Fernando Rodríguez-Artalejo

Open Access Commentary

New guidelines for the initial management of head injury

Carolyn M Benson, G Bryan Young

Open Access Commentary

Maternal plasma sequencing: a powerful tool towards fetal whole genome recovery

Elisavet A Papageorgiou, Philippos C Patsalis

Open Access Research article

The effect of statins on testosterone in men and women, a systematic review and meta-analysis of randomized controlled trials

C Mary Schooling, Shiu Lun Au Yeung, Guy Freeman, Benjamin J Cowling

Open Access Commentary

Do statins lower testosterone and does it matter?

Allan D Sniderman, George Thanassoulis

Open Access Opinion

Tackling overweight and obesity: does the public health message match the science?

Katherine Hafekost, David Lawrence, Francis Mitrou, Therese A O'Sullivan, Stephen R Zubrick

Open Access Research article

Impact of geriatric consultation teams on clinical outcome in acute hospitals: a systematic review and meta-analysis

Mieke Deschodt, Johan Flamaing, Patrick Haentjens, Steven Boonen, Koen Milisen

Open Access Commentary

Fascin-1 is a novel biomarker of aggressiveness in some carcinomas

Vathany Kulasingam, Eleftherios P Diamandis

Open Access Research article

Brain functional networks in syndromic and non-syndromic autism: a graph theoretical study of EEG connectivity

Jurriaan M Peters, Maxime Taquet, Clemente Vega, Shafali S Jeste, Iván Sánchez Fernández, Jacqueline Tan, Charles A Nelson III, Mustafa Sahin, Simon K Warfield

Open Access Research article

Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis

Vanessa Y Tan, Sarah J Lewis, Josephine C Adams, Richard M Martin

Open Access Research article

Worse prognosis of KRASc.35 G > A mutant metastatic colorectal cancer (MCRC) patients treated with intensive triplet chemotherapy plus bevacizumab (FIr-B/FOx)

Gemma Bruera, Katia Cannita, Daniela Di Giacomo, Aude Lamy, Thierry Frébourg, Jean Christophe Sabourin, Mario Tosi, Edoardo Alesse, Corrado Ficorella, Enrico Ricevuto

Open Access Research article

Summative assessments are more powerful drivers of student learning than resource intensive teaching formats

Tobias Raupach, Jamie Brown, Sven Anders, Gerd Hasenfuss, Sigrid Harendza

Open Access Research article

Evaluating complex interventions in End of Life Care: the MORECare Statement on good practice generated by a synthesis of transparent expert consultations and systematic reviews

Irene J Higginson, Catherine J Evans, Gunn Grande, Nancy Preston, Myfanwy Morgan, Paul McCrone, Penney Lewis, Peter Fayers, Richard Harding, Matthew Hotopf, Scott A Murray, Hamid Benalia, Marjolein Gysels, Morag Farquhar, Chris Todd

Open Access Opinion

Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression

Ian B Hickie, Sharon L Naismith, Rébecca Robillard, Elizabeth M Scott, Daniel F Hermens

Open Access Editorial

Novel pebbles in the mosaic of autoimmunity

Carlo Perricone, Nancy Agmon-Levin, Yehuda Shoenfeld

Open Access Research article

Use of illicit and prescription drugs for cognitive or mood enhancement among surgeons

Andreas G Franke, Christiana Bagusat, Pavel Dietz, Isabell Hoffmann, Perikles Simon, Rolf Ulrich, Klaus Lieb

Open Access Minireview

Advances in bladder cancer imaging

Shaista Hafeez, Robert Huddart

Open Access Research article

Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity

Yi-Chiung Hsu, Hsuan-Yu Chen, Shinsheng Yuan, Sung-Liang Yu, Chia-Hung Lin, Guani Wu, Pan-Chyr Yang, Ker-Chau Li

Open Access Correspondence

Integrating sepsis management recommendations into clinical care guidelines for district hospitals in resource-limited settings: the necessity to augment new guidelines with future research

Shevin T Jacob, Matthew Lim, Patrick Banura, Satish Bhagwanjee, Julian Bion, Allen C Cheng, Hillary Cohen, Jeremy Farrar, Sandy Gove, Philip Hopewell, Christopher C Moore, Cathy Roth, T Eoin West

Open Access Review

Evo-devo of human adolescence: beyond disease models of early puberty

Ze'ev Hochberg, Jay Belsky

Open Access Research article

Effects of breastfeeding on body composition and maturational tempo in the rat

Yonatan Crispel, Oren Katz, Dafna Ben-Yosef, Ze'ev Hochberg

Open Access Research article

Income and patient-reported outcomes (PROs) after primary total knee arthroplasty

Jasvinder A Singh, David G Lewallen

Open Access Question and Answer

Video Q&A: what is ASIA? An interview with Yehuda Shoenfeld

Yehuda Shoenfeld

Open Access Research article

Caregivers’ understanding of dementia predicts patients’ comfort at death: a prospective observational study

Jenny T van der Steen, Bregje D Onwuteaka-Philipsen, Dirk L Knol, Miel W Ribbe, Luc Deliens

Open Access Research article

Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors

Su-Jin Park, Birgit Sawitzki, Lan Kluwe, Victor F Mautner, Nikola Holtkamp, Andreas Kurtz

Open Access Research article

Physical comorbidities in men with mood and anxiety disorders: a population-based study

Livia Sanna, Amanda L Stuart, Julie A Pasco, Mark A Kotowicz, Michael Berk, Paolo Girardi, Sharon L Brennan, Lana J Williams

Open Access Research article

Drug eluting balloons for de novocoronary lesions – a systematic review and meta-analysis

Georg M Fröhlich, Alexandra J Lansky, Dennis T Ko, Olga Archangelidi, Rodney De Palma, Adam Timmis, Pascal Meier

Open Access Research article

Depression, antidepressant medications, and risk of Clostridium difficileinfection

Mary AM Rogers, M Todd Greene, Vincent B Young, Sanjay Saint, Kenneth M Langa, John Y Kao, David M Aronoff

Open Access Research article

Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study

Tao Xu, Christina Holzapfel, Xiao Dong, Erik Bader, Zhonghao Yu, Cornelia Prehn, Katrin Perstorfer, Marta Jaremek, Werner Roemisch-Margl, Wolfgang Rathmann, Yixue Li, H -Erich Wichmann, Henri Wallaschofski, Karl H Ladwig, Fabian Theis, Karsten Suhre, Jerzy Adamski, Thomas Illig, Annette Peters, Rui Wang-Sattler

Open Access Research article

Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine

Crystal D Hayes, Debleena Dey, Juan Pablo Palavicini, Hongjie Wang, Kshitij A Patkar, Dimitriy Minond, Adel Nefzi, Madepalli K Lakshmana

Open Access Research article

Calcium-deficiency assessment and biomarker identification by an integrated urinary metabonomics analysis

Maoqing Wang, Xue Yang, Fan Wang, Ran Li, Hua Ning, Lixin Na, Yifan Huang, Yue Song, Liyan Liu, Hongzhi Pan, Qiuju Zhang, Lijun Fan, Ying Li, Changhao Sun

Open Access Debate

Clinical classification in mental health at the cross-roads: which direction next?

Ian B Hickie, Jan Scott, Daniel F Hermens, Elizabeth M Scott, Sharon L Naismith, Adam J Guastella, Nick Glozier, Patrick D McGorry

Open Access Debate

Toward the future of psychiatric diagnosis: the seven pillars of RDoC

Bruce N Cuthbert, Thomas R Insel

Open Access Editorial

The DSM-5: Hyperbole, Hope or Hypothesis?

Michael Berk

Open Access Research article

How do autoimmune diseases cluster in families? A systematic review and meta-analysis

Jorge Cárdenas-Roldán, Adriana Rojas-Villarraga, Juan-Manuel Anaya

Open Access Review

The genomic landscape of chronic lymphocytic leukemia: clinical implications

Víctor Quesada, Andrew J Ramsay, David Rodríguez, Xose S Puente, Elías Campo, Carlos López-Otín

Open Access Review

Immunity, atherosclerosis and cardiovascular disease

Johan Frostegård

Open Access Debate

Depression as a risk factor for adverse outcomes in coronary heart disease

Kenneth E Freedland, Robert M Carney

Open Access Commentary

Patient advocacy and DSM-5

Dan J Stein, Katharine A Phillips

Open Access Research article

Body mass index and incident coronary heart disease in women: a population-based prospective study

Dexter Canoy, Benjamin J Cairns, Angela Balkwill, F Lucy Wright, Jane Green, Gillian Reeves, Valerie Beral

Open Access Review

Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile

Brenda WJH Penninx, Yuri Milaneschi, Femke Lamers, Nicole Vogelzangs

Open Access Debate

Depression as a non-causal variable risk marker in coronary heart disease

Anna Meijer, Marij Zuidersma, Peter de Jonge

Open Access Research article

Targeted rotavirus vaccination of high-risk infants; a low cost and highly cost-effective alternative to universal vaccination

Patricia Bruijning-Verhagen, Marie-Josée J Mangen, Mariet Felderhof, Nico G Hartwig, Marlies van Houten, Léon Winkel, Wouter J de Waal, Marc JM Bonten

Open Access Research article

A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model

Carina A Bäuerlein, Simone S Riedel, Jeanette Baker, Christian Brede, Ana-Laura Jordán Garrote, Martin Chopra, Miriam Ritz, Georg F Beilhack, Stephan Schulz, Robert Zeiser, Paul G Schlegel, Hermann Einsele, Robert S Negrin, Andreas Beilhack

Open Access Review

Novel therapeutic agents in clinical development for systemic lupus erythematosus

Natasha Jordan, Pamela MK Lutalo, David P D’Cruz

Open Access Research article

Characteristics, changes and influence of body composition during a 4486 km transcontinental ultramarathon: results from the Transeurope Footrace mobile whole body MRI-project

Uwe HW Schütz, Christian Billich, Kathrin König, Christian Würslin, Heike Wiedelbach, Hans-Jürgen Brambs, Jürgen Machann

Open Access Review

Personalized medicine in psychiatry: problems and promises

Uzoezi Ozomaro, Claes Wahlestedt, Charles B Nemeroff

Open Access Research article

Cost effectiveness of patient education for the prevention of falls in hospital: economic evaluation from a randomized controlled trial

Terry P Haines, Anne-Marie Hill, Keith D Hill, Sandra G Brauer, Tammy Hoffmann, Christopher Etherton-Beer, Steven M McPhail

Open Access Research article

Neuromuscular electrical stimulation for preventing skeletal-muscle weakness and wasting in critically ill patients: a systematic review

Nicola A Maffiuletti, Marc Roig, Eleftherios Karatzanos, Serafim Nanas

Open Access Research article

Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivoeffects on migration capacity and tumor growth

Carolina Belmar-Lopez, Gracia Mendoza, Daniel Oberg, Jerome Burnet, Carlos Simon, Irene Cervello, Maite Iglesias, Juan Carlos Ramirez, Pilar Lopez-Larrubia, Miguel Quintanilla, Pilar Martin-Duque

Open Access Research article

Is a combination of varenicline and nicotine patch more effective in helping smokers quit than varenicline alone? A randomised controlled trial

Peter Hajek, Katie Myers Smith, Al-Rehan Dhanji, Hayden McRobbie

Open Access Commentary

Processing of meats and cardiovascular risk: time to focus on preservatives

Renata Micha, Georgios Michas, Martin Lajous, Dariush Mozaffarian

Open Access Commentary

Tobacco smoking and depression: time to move on to a new research paradigm in medicine?

Peter de Jonge, Elisabeth Henriette Bos

Open Access Research article

Are behavioral interventions effective in increasing physical activity at 12 to 36 months in adults aged 55 to 70 years? a systematic review and meta-analysis

Nicola Hobbs, Alan Godfrey, Jose Lara, Linda Errington, Thomas D Meyer, Lynn Rochester, Martin White, John C Mathers, Falko F Sniehotta

Open Access Research article

Sodium vanadate combined with l-ascorbic acid delays disease progression, enhances motor performance, and ameliorates muscle atrophy and weakness in mice with spinal muscular atrophy

Huei-Chun Liu, Chen-Hung Ting, Hsin-Lan Wen, Li-Kai Tsai, Hsiu-Mei Hsieh-Li, Hung Li, Sue Lin-Chao

Open Access Debate

When to start antiretroviral therapy: as soon as possible

Ricardo A Franco, Michael S Saag

Open Access Debate

When to start antiretroviral therapy: the need for an evidence base during early HIV infection

Jens D Lundgren, Abdel G Babiker, Fred M Gordin, Álvaro H Borges, James D Neaton

Open Access Minireview

Origins of increased airway smooth muscle mass in asthma

Rachid Berair, Ruth Saunders, Christopher E Brightling

Open Access Review

The collateral circulation of the heart

Pascal Meier, Stephan H Schirmer, Alexandra J Lansky, Adam Timmis, Bertram Pitt, Christian Seiler

Open Access Question and Answer

Video Q&A: molecular profiling of breast cancer

Carlos Caldas

Open Access Minireview

Genetic heterogeneity in breast cancer: the road to personalized medicine?

Richard D Baird, Carlos Caldas

Open Access Research article

Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells

Georg Siegel, Torsten Kluba, Ursula Hermanutz-Klein, Karen Bieback, Hinnak Northoff, Richard Schäfer

Open Access Research article

Factors associated with patient, and diagnostic delays in Chinese TB patients: a systematic review and meta-analysis

Ying Li, John Ehiri, Shenglan Tang, Daikun Li, Yongqiao Bian, Hui Lin, Caitlin Marshall, Jia Cao

Open Access Review

New insights into mechanisms behind miscarriage

Elisabeth Clare Larsen, Ole Bjarne Christiansen, Astrid Marie Kolte, Nick Macklon

Open Access Research article

Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis

Andrea C Tricco, Ayman Chit, Charlene Soobiah, David Hallett, Genevieve Meier, Maggie H Chen, Mariam Tashkandi, Chris T Bauch, Mark Loeb

Open Access Research article

Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease

Adam E Handel, Geir K Sandve, Giulio Disanto, Antonio J Berlanga-Taylor, Giuseppe Gallone, Heather Hanwell, Finn Drabløs, Gavin Giovannoni, George C Ebers, Sreeram V Ramagopalan

Open Access Opinion

Personalizing guidelines for diabetes management: twilight or dawn of the expert?

Stavroula A Paschou, Richard David Leslie

Open Access Research article

Frequency of nut consumption and mortality risk in the PREDIMED nutrition intervention trial

Marta Guasch-Ferré, Mònica Bulló, Miguel Ángel Martínez-González, Emilio Ros, Dolores Corella, Ramon Estruch, Montserrat Fitó, Fernando Arós, Julia Wärnberg, Miquel Fiol, José Lapetra, Ernest Vinyoles, Rosa Maria Lamuela-Raventós, Lluís Serra-Majem, Xavier Pintó, Valentina Ruiz-Gutiérrez, Josep Basora, Jordi Salas-Salvadó

Open Access Commentary

Should we go nuts about nuts?

Sabine Rohrmann, David Faeh

Open Access Research article

Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial

Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Huimin Zhou, Zhaohui Yin, Yana Chen, Ye Zhang, Shanfeng Wang, Jie Shen, Hatim Thaker, Summit Jain, Yunxiang Li, Yalin Diao, Yingjian Chen, Xiaoming Sun, Mary Beth Fisk, Heng Li

Open Access Research article

Evaluation of the acceptability and usefulness of an information website for caregivers of people with bipolar disorder

Lesley Berk, Michael Berk, Seetal Dodd, Claire Kelly, Stefan Cvetkovski, Anthony Francis Jorm

Open Access Debate

Diabetic retinopathy in sub-Saharan Africa: meeting the challenges of an emerging epidemic

Philip I Burgess, Gerald Msukwa, Nicholas AV Beare

Open Access Research article

Hospital admissions for vitamin D related conditions and subsequent immune-mediated disease: record-linkage studies

Sreeram V Ramagopalan, Raph Goldacre, Giulio Disanto, Gavin Giovannoni, Michael J Goldacre

Open Access Research article

Chronic cerebrospinal venous insufficiency is not associated with cognitive impairment in multiple sclerosis

Ralph HB Benedict, Bianca Weinstock-Guttmam, Karen Marr, Vesela Valnarov, Cheryl Kennedy, Ellen Carl, Christina Brooks, David Hojnacki, Robert Zivadinov

Open Access Research article

Comparative assessment of absolute cardiovascular disease risk characterization from non-laboratory-based risk assessment in South African populations

Thomas A Gaziano, Ankur Pandya, Krisela Steyn, Naomi Levitt, Willie Mollentze, Gina Joubert, Corinna M Walsh, Ayesha A Motala, Annamarie Kruger, Aletta E Schutte, Datshana P Naidoo, Dorcas R Prakaschandra, Ria Laubscher

Open Access Research article

Safety of TNF-α inhibitors during IBD pregnancy: a systematic review

Ole Haagen Nielsen, Edward V Loftus Jr, Tine Jess

Open Access Research article

Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines

Amarjargal Dashdorj, Jyothi KR, Sangbin Lim, Ara Jo, Minh Nam Nguyen, Joohun Ha, Kyung-Sik Yoon, Hyo Jong Kim, Jae-Hoon Park, Michael P Murphy, Sung Soo Kim

Open Access Opinion

Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness

Michael Berk, Olivia Dean, Hemmo Drexhage, John J McNeil, Steven Moylan, Adrienne O'Neil, Christopher G Davey, Livia Sanna, Michael Maes

Open Access Review

Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era

John F Brothers, Kahkeshan Hijazi, Celine Mascaux, Randa A El-Zein, Margaret R Spitz, Avrum Spira

Open Access Commentary

Sleeping well

Mithu Sen, G Bryan Young

Open Access Commentary

Geriatric consultation services-are wards more effective than teams?

Ian D Cameron, Susan Kurrle

Open Access Research article

A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial

Ian D Cameron, Nicola Fairhall, Colleen Langron, Keri Lockwood, Noeline Monaghan, Christina Aggar, Catherine Sherrington, Stephen R Lord, Susan E Kurrle

Open Access Opinion

Drug-induced dyskinesia in Parkinson's disease. Should success in clinical management be a function of improvement of motor repertoire rather than amplitude of dyskinesia?

Jean-François Daneault, Benoit Carignan, Abbas F Sadikot, Michel Panisset, Christian Duval

Open Access Research article

Serum concentrations of 25-hydroxyvitamin D and immunoglobulins in an older Swiss cohort: results of the Senior Labor Study

Benjamin Sakem, Cristina Nock, Zeno Stanga, Pedro Medina, Urs E Nydegger, Martin Risch, Lorenz Risch

Open Access Review

The sweet and sour of serological glycoprotein tumor biomarker quantification

Uros Kuzmanov, Hari Kosanam, Eleftherios P Diamandis

Open Access Research article

Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data

George M Warimwe, Helen A Fletcher, Ally Olotu, Selidji T Agnandji, Adrian VS Hill, Kevin Marsh, Philip Bejon

Open Access Research article

A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways

Robert P Anderson, Margaret J Henry, Roberta Taylor, Emma L Duncan, Patrick Danoy, Marylia J Costa, Kathryn Addison, Jason A Tye-Din, Mark A Kotowicz, Ross E Knight, Wendy Pollock, Geoffrey C Nicholson, Ban-Hock Toh, Matthew A Brown, Julie A Pasco

Open Access Research article

Plasma procalcitonin is associated with all-cause and cancer mortality in apparently healthy men: a prospective population-based study

Ovidiu S Cotoi, Jonas Manjer, Bo Hedblad, Gunnar Engström, Olle Melander, Alexandru Schiopu

Open Access Research article

Systematic review of clinical practice guidelines in the diagnosis and management of thyroid nodules and cancer

Tsai-Wei Huang, Jun-Hung Lai, Mei-Yi Wu, Shiah-Lian Chen, Chih-Hsiung Wu, Ka-Wai Tam

Open Access Research article

Associations between smoking, components of metabolic syndrome and lipoprotein particle size

Sandra N Slagter, Jana V van Vliet-Ostaptchouk, Judith M Vonk, H Marike Boezen, Robin PF Dullaart, Anneke C Muller Kobold, Edith J Feskens, André P van Beek, Melanie M van derKlauw, Bruce HR Wolffenbuttel

Open Access Research article

Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III

Xinqing Deng, Yiqing Song, JoAnn E Manson, Lisa B Signorello, Shumin M Zhang, Martha J Shrubsole, Reid M Ness, Douglas L Seidner, Qi Dai

Open Access Research article

A method for inferring medical diagnoses from patient similarities

Assaf Gottlieb, Gideon Y Stein, Eytan Ruppin, Russ B Altman, Roded Sharan

Open Access Commentary

Diagnostic heterogeneity in psychiatry: towards an empirical solution

Klaas J Wardenaar, Peter de Jonge

Open Access Research article

Mediterranean dietary pattern and depression: the PREDIMED randomized trial

Almudena Sánchez-Villegas, Miguel Angel Martínez-González, Ramón Estruch, Jordi Salas-Salvadó, Dolores Corella, Maria Isabel Covas, Fernando Arós, Dora Romaguera, Enrique Gómez-Gracia, José Lapetra, Xavier Pintó, Jose Alfredo Martínez, Rosa María Lamuela-Raventós, Emilio Ros, Alfredo Gea, Julia Wärnberg, Lluis Serra-Majem

Open Access Opinion

So depression is an inflammatory disease, but where does the inflammation come from?

Michael Berk, Lana J Williams, Felice N Jacka, Adrienne O’Neil, Julie A Pasco, Steven Moylan, Nicholas B Allen, Amanda L Stuart, Amie C Hayley, Michelle L Byrne, Michael Maes

Open Access Review

Pharmacological treatments in ARDS; a state-of-the-art update

Andrew James Boyle, Rob Mac Sweeney, Daniel Francis McAuley

Open Access Research article

Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial

Estefania Toledo, Frank B Hu, Ramon Estruch, Pilar Buil-Cosiales, Dolores Corella, Jordi Salas-Salvadó, M Isabel Covas, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, Jose Lapetra, Luis Serra-Majem, Xavier Pinto, Rosa M Lamuela-Raventós, Guillermo Saez, Mònica Bulló, Valentina Ruiz-Gutiérrez, Emilio Ros, José V Sorli, Miguel Angel Martinez-Gonzalez

Open Access Research article

Perineal Assessment and Repair Longitudinal Study (PEARLS): a matched-pair cluster randomized trial

Khaled M K Ismail, Christine Kettle, Sue E Macdonald, Sue Tohill, Peter W Thomas, Debra Bick

Open Access Research article

Hypnotics and mortality in an elderly general population: a 12-year prospective study

Isabelle Jaussent, Marie-Laure Ancelin, Claudine Berr, Karine Pérès, Jacqueline Scali, Alain Besset, Karen Ritchie, Yves Dauvilliers

Open Access Research article

Development and evaluation of the feasibility and effects on staff, patients, and families of a new tool, the Psychosocial Assessment and Communication Evaluation (PACE), to improve communication and palliative care in intensive care and during clinical uncertainty

Irene J Higginson, Jonathan Koffman, Philip Hopkins, Wendy Prentice, Rachel Burman, Sara Leonard, Caroline Rumble, Jo Noble, Odette Dampier, William Bernal, Sue Hall, Myfanwy Morgan, Cathy Shipman

Open Access Research article

Transmission potential of influenza A/H7N9, February to May 2013, China

Gerardo Chowell, Lone Simonsen, Sherry Towers, Mark A Miller, Cécile Viboud

Open Access Research article

A combined community- and facility-based approach to improve pregnancy outcomes in low-resource settings: a Global Network cluster randomized trial

Omrana Pasha, Elizabeth M McClure, Linda L Wright, Sarah Saleem, Shivaprasad S Goudar, Elwyn Chomba, Archana Patel, Fabian Esamai, Ana Garces, Fernando Althabe, Bhala Kodkany, Hillary Mabeya, Albert Manasyan, Waldemar A Carlo, Richard J Derman, Patricia L Hibberd, Edward K Liechty, Nancy Krebs, K Michael Hambidge, Pierre Buekens, Janet Moore, Alan H Jobe, Marion Koso-Thomas, Dennis D Wallace, Suzanne Stalls, Robert L Goldenberg

Open Access Research article

Which placebo to cure depression? A thought-provoking network meta-analysis

Florian Naudet, Bruno Millet, Philippe Charlier, Jean Michel Reymann, Anne Solène Maria, Bruno Falissard

Open Access Research article

Physical activity and clustered cardiovascular disease risk factors in young children: a cross-sectional study (the IDEFICS study)

David Jiménez-Pavón, Kenn Konstabel, Patrick Bergman, Wolfgang Ahrens, Hermann Pohlabeln, Charalampos Hadjigeorgiou, Alfonso Siani, Licia Iacoviello, Dénes Molnár, Stefaan De Henauw, Yannis Pitsiladis, Luis A Moreno

Open Access Research article

The relationship of Asperger’s syndrome to autism: a preliminary EEG coherence study

Frank H Duffy, Aditi Shankardass, Gloria B McAnulty, Heidelise Als

Open Access Review

Personalizing health care: feasibility and future implications

Brian Godman, Alexander E Finlayson, Parneet K Cheema, Eva Zebedin-Brandl, Inaki Gutiérrez-Ibarluzea, Jan Jones, Rickard E Malmström, Elina Asola, Christoph Baumgärtel, Marion Bennie, Iain Bishop, Anna Bucsics, Stephen Campbell, Eduardo Diogene, Alessandra Ferrario, Jurij Fürst, Kristina Garuoliene, Miguel Gomes, Katharine Harris, Alan Haycox, Harald Herholz, Krystyna Hviding, Saira Jan, Marija Kalaba, Christina Kvalheim, Ott Laius, Sven-Ake Lööv, Kamila Malinowska, Andrew Martin, Laura McCullagh, Fredrik Nilsson, Ken Paterson, Ulrich Schwabe, Gisbert Selke, Catherine Sermet, Steven Simoens, Dominik Tomek, Vera Vlahovic-Palcevski, Luka Voncina, Magdalena Wladysiuk, Menno van Woerkom, Durhane Wong-Rieger, Corrine Zara, Raghib Ali, Lars L Gustafsson

Open Access Review

Mechanisms and impact of the frequent exacerbator phenotype in chronic obstructive pulmonary disease

Jadwiga A Wedzicha, Simon E Brill, James P Allinson, Gavin C Donaldson

Open Access Review

Challenges and opportunities for oral pre-exposure prophylaxis in the prevention of HIV infection: where are we in Europe?

Jean-Michel Molina, Claire Pintado, Caroline Gatey, Diane Ponscarme, Pierre Charbonneau, Benedicte Loze, Willy Rozenbaum, Constance Delaugerre

Open Access Research article

Additional Saturday rehabilitation improves functional independence and quality of life and reduces length of stay: a randomized controlled trial

Casey L Peiris, Nora Shields, Natasha K Brusco, Jennifer J Watts, Nicholas F Taylor

Open Access Commentary

Increasing the dose of acute rehabilitation: is there a benefit?

Ann M Parker, Robert K Lord, Dale M Needham

Open Access Forum

DSM-5: a collection of psychiatrist views on the changes, controversies, and future directions

Charles B Nemeroff, Daniel Weinberger, Michael Rutter, Harriet L MacMillan, Richard A Bryant, Simon Wessely, Dan J Stein, Carmine M Pariante, Florian Seemüller, Michael Berk, Gin S Malhi, Martin Preisig, Martin Brüne, Paul Lysaker

Open Access Question and Answer

DSM-5 and ADHD – an interview with Eric Taylor

Eric Taylor

Open Access Research article

Integrating multiple ‘omics’ analyses identifies serological protein biomarkers for preeclampsia

Linda Y Liu, Ting Yang, Jun Ji, Qiaojun Wen, Alexander A Morgan, Bo Jin, Gongxing Chen, Deirdre J Lyell, David K Stevenson, Xuefeng B Ling, Atul J Butte

Open Access Opinion

The link between chronic periodontitis and COPD: a common role for the neutrophil?

Adam KH Usher, Robert A Stockley

Open Access Research article

Incidence, characteristics and risk factors of adverse drug reactions in hospitalized children – a prospective observational cohort study of 6,601 admissions

Signe Thiesen, Elizabeth J Conroy, Jennifer R Bellis, Louise E Bracken, Helena L Mannix, Kim A Bird, Jennifer C Duncan, Lynne Cresswell, Jamie J Kirkham, Matthew Peak, Paula R Williamson, Anthony J Nunn, Mark A Turner, Munir Pirmohamed, Rosalind L Smyth

Open Access Review

Managing HIV/hepatitis C co-infection in the era of direct acting antivirals

Jürgen K Rockstroh, Sanjay Bhagani

Open Access Research article

Construct-level predictive validity of educational attainment and intellectual aptitude tests in medical student selection: meta-regression of six UK longitudinal studies

IC McManus, Chris Dewberry, Sandra Nicholson, Jonathan S Dowell, Katherine Woolf, Henry WW Potts

Open Access Commentary

Selecting the right medical student

Sam Leinster

Open Access Opinion

Cognitive health begins at conception: addressing dementia as a lifelong and preventable condition

Jennifer H Barnett, Vladimir Hachinski, Andrew D Blackwell

Open Access Review

Admission prevention in COPD: non-pharmacological management

Eui-Sik Suh, Swapna Mandal, Nicholas Hart

Open Access Opinion

What if HIV were unable to develop resistance against a new therapeutic agent?

Mark A Wainberg, Thibault Mesplède, Francois Raffi

Open Access Research article

Effectiveness of Primary Care Triple P on child psychosocial problems in preventive child healthcare: a randomized controlled trial

Willem Spijkers, Daniëlle EMC Jansen, Sijmen A Reijneveld

Open Access Research article

Containing the accidental laboratory escape of potential pandemic influenza viruses

Stefano Merler, Marco Ajelli, Laura Fumanelli, Alessandro Vespignani

Open Access Research article

Who uses emergency departments inappropriately and when - a national cross-sectional study using a monitoring data system

Philip McHale, Sara Wood, Karen Hughes, Mark A Bellis, Ulf Demnitz, Sacha Wyke

Open Access Commentary

Simple steps to equity in child survival

Stuart Gilmour, Kenji Shibuya

Open Access Research article

The effectiveness of police custody assessments in identifying suspects with intellectual disabilities and attention deficit hyperactivity disorder

Susan Young, Emily J Goodwin, Ottilie Sedgwick, Gisli H Gudjonsson

Open Access Erratum

Erratum to: Additional Saturday rehabilitation improves functional independence and quality of life and reduces length of stay: a randomized controlled trial

Casey L Peiris, Nora Shields, Natasha K Brusco, Jennifer J Watts, Nicholas F Taylor

Open Access Research article

Multimorbidity in bipolar disorder and undertreatment of cardiovascular disease: a cross sectional study

Daniel J Smith, Daniel Martin, Gary McLean, Julie Langan, Bruce Guthrie, Stewart W Mercer

Open Access Commentary

Pre-hypertension: another 'pseudodisease’?

Pascal Meier, Franz H Messerli, Andreas Baumbach, Alexandra J Lansky

Open Access Opinion

Allergen immunotherapy and allergic rhinitis: false beliefs

Moisés A Calderón, A William Frankland, Pascal Demoly

Open Access Research article

Quantifying circulating hypoxia-induced RNA transcripts in maternal blood to determine in uterofetal hypoxic status

Clare Whitehead, Wan Tinn Teh, Susan P Walker, Cheryl Leung, Sonali Mendis, Luke Larmour, Stephen Tong

Open Access Question and Answer

The DSM-5 - an interview with David Kupfer

David Kupfer

Open Access Commentary

Approach to the older patient with cancer

Maxine de la Cruz, Eduardo Bruera

Open Access Research article

Prehypertension and incidence of cardiovascular disease: a meta-analysis

Yuli Huang, Sheng Wang, Xiaoyan Cai, Weiyi Mai, Yunzhao Hu, Hongfeng Tang, Dingli Xu

Open Access Research article

Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial

Tatsufumi Nakamura, Tomohiro Matsuo, Taku Fukuda, Shinji Yamato, Kentaro Yamaguchi, Ikuo Kinoshita, Toshio Matsuzaki, Yoshihiro Nishiura, Kunihiko Nagasato, Tomoko Narita-Masuda, Hideki Nakamura, Katsuya Satoh, Hitoshi Sasaki, Hideki Sakai, Atsushi Kawakami

Open Access Opinion

The Hyperferritinemic Syndrome: macrophage activation syndrome, Still’s disease, septic shock and catastrophic antiphospholipid syndrome

Cristina Rosário, Gisele Zandman-Goddard, Esther G Meyron-Holtz, David P D’Cruz, Yehuda Shoenfeld

Open Access Commentary

Procalcitonin beyond the acute phase: novel biomediator properties?

Carolina Panico, Eric Nylen

Open Access Review

Rapid diagnostics of tuberculosis and drug resistance in the industrialized world: clinical and public health benefits and barriers to implementation

Francis Drobniewski, Vladyslav Nikolayevskyy, Horst Maxeiner, Yanina Balabanova, Nicola Casali, Irina Kontsevaya, Olga Ignatyeva

Open Access Research article

Alcohol intake, wine consumption and the development of depression: the PREDIMED study

Alfredo Gea, Juan J Beunza, Ramón Estruch, Almudena Sánchez-Villegas, Jordi Salas-Salvadó, Pilar Buil-Cosiales, Enrique Gómez-Gracia, María-Isabel Covas, Dolores Corella, Miquel Fiol, Fernando Arós, José Lapetra, Rosa-María Lamuela-Raventós, Julia Wärnberg, Xavier Pintó, Lluis Serra-Majem, Miguel A Martínez-González

Open Access Erratum

Erratum to: Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial

Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, James F List

Open Access Commentary

Is it smoking or related lifestyle variables that increase metabolic syndrome risk?

Mikael Rabaeus, Patricia Salen, Michel de Lorgeril

Open Access Minireview

What is next after the genes for autoimmunity?

John Castiblanco, Mauricio Arcos-Burgos, Juan-Manuel Anaya

Open Access Research article

Comparing sociocultural features of cholera in three endemic African settings

Christian Schaetti, Neisha Sundaram, Sonja Merten, Said M Ali, Erick O Nyambedha, Bruno Lapika, Claire-Lise Chaignat, Raymond Hutubessy, Mitchell G Weiss

Open Access Research article

Dietary intake of n-3 long-chain polyunsaturated fatty acids and risk of myocardial infarction in coronary artery disease patients with or without diabetes mellitus: a prospective cohort study

Elin Strand, Eva R Pedersen, Gard FT Svingen, Hall Schartum-Hansen, Eirik W Rebnord, Bodil Bjørndal, Reinhard Seifert, Pavol Bohov, Klaus Meyer, J Kalervo Hiltunen, Jan E Nordrehaug, Dennis WT Nilsen, Rolf K Berge, Ottar Nygård

Open Access Minireview

B. anthracisassociated cardiovascular dysfunction and shock: the potential contribution of both non-toxin and toxin components

Kenneth E Remy, Ping Qiu, Yan Li, Xizhong Cui, Peter Q Eichacker

Open Access Review

Venous endothelial injury in central nervous system diseases

Jonathan S Alexander, Leonard Prouty, Ikuo Tsunoda, Chaitanya Vijay Ganta, Alireza Minagar

Open Access Correspondence

Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration

Lisa M McShane, Margaret M Cavenagh, Tracy G Lively, David A Eberhard, William L Bigbee, P Mickey Williams, Jill P Mesirov, Mei-Yin C Polley, Kelly Y Kim, James V Tricoli, Jeremy MG Taylor, Deborah J Shuman, Richard M Simon, James H Doroshow, Barbara A Conley

Open Access Research article

DNA barcoding detects contamination and substitution in North American herbal products

Steven G Newmaster, Meghan Grguric, Dhivya Shanmughanandhan, Sathishkumar Ramalingam, Subramanyam Ragupathy

Open Access Forum

Global health: the importance of evidence-based medicine

Gretchen L Birbeck, Charles S Wiysonge, Edward J Mills, Julio J Frenk, Xiao-Nong Zhou, Prabhat Jha

Open Access Commentary

Millennium Development Goals 4 and 5: progress and challenges

Jennifer Bryce, Robert E Black, Cesar G Victora

Open Access Commentary

Secular trends in new childhood epidemics: insights from evolutionary medicine

Martin Brüne, Ze’ev Hochberg

Open Access Research article

Impact of a population-based HPV vaccination program on cervical abnormalities: a data linkage study

Dorota M Gertig, Julia ML Brotherton, Alison C Budd, Kelly Drennan, Genevieve Chappell, A Marion Saville

Open Access Research article

Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity

Michael K Skinner, Mohan Manikkam, Rebecca Tracey, Carlos Guerrero-Bosagna, Muksitul Haque, Eric E Nilsson

Open Access Commentary

Magnesium deficit - overlooked cause of low vitamin D status?

Armin Zittermann

Open Access Research article

Irisin and exercise training in humans – Results from a randomized controlled training trial

Anne Hecksteden, Melissa Wegmann, Anke Steffen, Jochen Kraushaar, Arne Morsch, Sandra Ruppenthal, Lars Kaestner, Tim Meyer

Open Access Research article

Adverse drug reactions and off-label and unlicensed medicines in children: a nested case?control study of inpatients in a pediatric hospital

Jennifer R Bellis, Jamie J Kirkham, Signe Thiesen, Elizabeth J Conroy, Louise E Bracken, Helena L Mannix, Kim A Bird, Jennifer C Duncan, Matthew Peak, Mark A Turner, Rosalind L Smyth, Anthony J Nunn, Munir Pirmohamed

Open Access Research article

Diagnostic indicators of non-cardiovascular chest pain: a systematic review and meta-analysis

Maria M Wertli, Katrin B Ruchti, Johann Steurer, Ulrike Held

Open Access Research article

The contribution of major depression to the global burden of ischemic heart disease: a comparative risk assessment

Fiona J Charlson, Andrew E Moran, Greg Freedman, Rosana E Norman, Nicolas JC Stapelberg, Amanda J Baxter, Theo Vos, Harvey A Whiteford

Open Access Review

Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review

Stephen D Lawn, Graeme Meintjes, Helen McIlleron, Anthony D Harries, Robin Wood

Open Access Debate

Challenges in cardiac device innovation: is neuroimaging an appropriate endpoint? Consensus from the 2013 Yale-UCL Cardiac Device Innovation Summit

Stephanie M Meller, Andreas Baumbach, Szilard Voros, Michael Mullen, Alexandra J Lansky

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