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Zeitschrift

BMC Medicine

BMC Medicine 1/2019

Ausgabe 1/2019

Inhaltsverzeichnis ( 228 Artikel )

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis

WWARN K13 Genotype-Phenotype Study Group

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Morbidity, mortality and missed appointments in healthcare: a national retrospective data linkage study

Ross McQueenie, David A. Ellis, Alex McConnachie, Philip Wilson, Andrea E. Williamson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

NMR-based metabolomics identifies patients at high risk of death within two years after acute myocardial infarction in the AMI-Florence II cohort

Alessia Vignoli, Leonardo Tenori, Betti Giusti, Panteleimon G. Takis, Serafina Valente, Nazario Carrabba, Daniela Balzi, Alessandro Barchielli, Niccolò Marchionni, Gian Franco Gensini, Rossella Marcucci, Claudio Luchinat, Anna Maria Gori

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

HIV-1 molecular transmission clusters in nine European countries and Canada: association with demographic and clinical factors

Dimitrios Paraskevis, Apostolos Beloukas, Kostantinos Stasinos, Nikos Pantazis, Carmen de Mendoza, Norbert Bannert, Laurence Meyer, Robert Zangerle, John Gill, Maria Prins, Antonella d’Arminio Montforte, Anne-Marte Bakken Kran, Kholoud Porter, Giota Touloumi, on behalf of the CASCADE collaboration of EuroCoord

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Effects of a lifestyle intervention during pregnancy to prevent excessive gestational weight gain in routine care – the cluster-randomised GeliS trial

Julia Kunath, Julia Günther, Kathrin Rauh, Julia Hoffmann, Lynne Stecher, Eva Rosenfeld, Luzia Kick, Kurt Ulm, Hans Hauner

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Implementation science and stigma reduction interventions in low- and middle-income countries: a systematic review

Christopher G. Kemp, Brooke A. Jarrett, Churl-Su Kwon, Lanxin Song, Nathalie Jetté, Jaime C. Sapag, Judith Bass, Laura Murray, Deepa Rao, Stefan Baral

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Challenges and opportunities in examining and addressing intersectional stigma and health

Janet M. Turan, Melissa A. Elafros, Carmen H. Logie, Swagata Banik, Bulent Turan, Kaylee B. Crockett, Bernice Pescosolido, Sarah M. Murray

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Safety, activity, and molecular heterogeneity following neoadjuvant non-pegylated liposomal doxorubicin, paclitaxel, trastuzumab, and pertuzumab in HER2-positive breast cancer (Opti-HER HEART): an open-label, single-group, multicenter, phase 2 trial

Joaquín Gavilá, Mafalda Oliveira, Tomás Pascual, Jose Perez-Garcia, Xavier Gonzàlez, Jordi Canes, Laia Paré, Isabel Calvo, Eva Ciruelos, Montserrat Muñoz, Juan A. Virizuela, Isabel Ruiz, Raquel Andrés, Antonia Perelló, Jerónimo Martínez, Serafín Morales, Mercedes Marín-Aguilera, Débora Martínez, Juan C. Quero, Antonio Llombart-Cussac, Aleix Prat

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The impact of repeated vaccination on influenza vaccine effectiveness: a systematic review and meta-analysis

Lauren C. Ramsay, Sarah A. Buchan, Robert G. Stirling, Benjamin J. Cowling, Shuo Feng, Jeffrey C. Kwong, Bryna F. Warshawsky

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis

Monica Bolton, Alex Hodkinson, Shivani Boda, Alan Mould, Maria Panagioti, Sarah Rhodes, Lisa Riste, Harm van Marwijk

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

Real-world data and the patient perspective: the PROmise of social media?

Laura McDonald, Bill Malcolm, Sreeram Ramagopalan, Hayley Syrad

01.12.2019 | Mini Review | Ausgabe 1/2019 Open Access

The democratization of scientific publishing

Clare Fiala, Eleftherios P. Diamandis

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

Out of the silos: identifying cross-cutting features of health-related stigma to advance measurement and intervention

Wim H. van Brakel, Janine Cataldo, Sandeep Grover, Brandon A. Kohrt, Laura Nyblade, Melissa Stockton, Edwin Wouters, Lawrence H. Yang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

From high to low malaria transmission in Zanzibar—challenges and opportunities to achieve elimination

A. Björkman, D. Shakely, A. S. Ali, U. Morris, H. Mkali, A. K. Abbas, A-W Al-Mafazy, K. A. Haji, J. Mcha, R. Omar, J. Cook, K. Elfving, M. Petzold, M. C. Sachs, B. Aydin-Schmidt, C. Drakeley, M. Msellem, A. Mårtensson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The effect of a lifestyle intervention in obese pregnant women on gestational metabolic profiles: findings from the UK Pregnancies Better Eating and Activity Trial (UPBEAT) randomised controlled trial

Harriet L. Mills, Nashita Patel, Sara L. White, Dharmintra Pasupathy, Annette L. Briley, Diana L. Santos Ferreira, Paul T. Seed, Scott M. Nelson, Naveed Sattar, Kate Tilling, Lucilla Poston, Deborah A. Lawlor, On behalf of the UPBEAT Consortium

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Clinical and economic outcomes of remotely delivered cognitive behaviour therapy versus treatment as usual for repeat unscheduled care users with severe health anxiety: a multicentre randomised controlled trial

Richard Morriss, Shireen Patel, Sam Malins, Boliang Guo, Fred Higton, Marilyn James, Mengjun Wu, Paula Brown, Naomi Boycott, Catherine Kaylor-Hughes, Martin Morris, Emma Rowley, Jayne Simpson, David Smart, Michelle Stubley, Joe Kai, Helen Tyrer

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A scoping review of health-related stigma outcomes for high-burden diseases in low- and middle-income countries

Jeremy C. Kane, Melissa A. Elafros, Sarah M. Murray, Ellen M. H. Mitchell, Jura L. Augustinavicius, Sara Causevic, Stefan D. Baral

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo

Michael Berk, Alyna Turner, Gin S. Malhi, Chee H. Ng, Susan M. Cotton, Seetal Dodd, Yuval Samuni, Michelle Tanious, Claire McAulay, Nathan Dowling, Jerome Sarris, Lauren Owen, Astrid Waterdrinker, Deidre Smith, Olivia M. Dean

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The association between adherence to the Mediterranean diet and hepatic steatosis: cross-sectional analysis of two independent studies, the UK Fenland Study and the Swiss CoLaus Study

Saman Khalatbari-Soltani, Fumiaki Imamura, Soren Brage, Emanuella De Lucia Rolfe, Simon J Griffin, Nicholas J Wareham, Pedro Marques-Vidal, Nita G Forouhi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Mortality after inpatient treatment for diarrhea in children: a cohort study

Alison Talbert, Moses Ngari, Evasius Bauni, Martha Mwangome, Neema Mturi, Mark Otiende, Kathryn Maitland, Judd Walson, James A. Berkley

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Disparities in access to diagnosis and care in Blantyre, Malawi, identified through enhanced tuberculosis surveillance and spatial analysis

Peter MacPherson, McEwen Khundi, Marriott Nliwasa, Augustine T. Choko, Vincent K. Phiri, Emily L. Webb, Peter J. Dodd, Ted Cohen, Rebecca Harris, Elizabeth L. Corbett

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Antibody responses to merozoite antigens after natural Plasmodium falciparum infection: kinetics and longevity in absence of re-exposure

Victor Yman, Michael T. White, Muhammad Asghar, Christopher Sundling, Klara Sondén, Simon J. Draper, Faith H. A. Osier, Anna Färnert

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Are China’s oldest-old living longer with less disability? A longitudinal modeling analysis of birth cohorts born 10 years apart

Zuyun Liu, Ling Han, Qiushi Feng, Matthew E. Dupre, Danan Gu, Heather G. Allore, Thomas M. Gill, Collin F. Payne

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Discontinuation of adjuvant hormone therapy among breast cancer patients not previously attending mammography screening

Wei He, Louise Eriksson, Sven Törnberg, Fredrik Strand, Per Hall, Kamila Czene

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Stigma in health facilities: why it matters and how we can change it

Laura Nyblade, Melissa A. Stockton, Kayla Giger, Virginia Bond, Maria L. Ekstrand, Roger Mc Lean, Ellen M. H. Mitchell, La Ron E. Nelson, Jaime C. Sapag, Taweesap Siraprapasiri, Janet Turan, Edwin Wouters

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The potential impact and cost-effectiveness of tobacco reduction strategies for tuberculosis prevention in Canadian Inuit communities

Dieynaba S. N’Diaye, Ntwali Placide Nsengiyumva, Aashna Uppal, Olivia Oxlade, Gonzalo G. Alvarez, Kevin Schwartzman

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns

Lina Zhang, Lulu Song, Bingqing Liu, Mingyang Wu, Lulin Wang, Bin Zhang, Chao Xiong, Wei Xia, Yuanyuan Li, Zhongqiang Cao, Youjie Wang, Shunqing Xu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Deferred and referred deliveries contribute to stillbirths in the Indian state of Bihar: results from a population-based survey of all births

Rakhi Dandona, G. Anil Kumar, Md. Akbar, Debarshi Bhattacharya, Priya Nanda, Lalit Dandona

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

On the estimation of population cause-specific mortality fractions from in-hospital deaths

Gail M. Williams, Ian Douglas Riley, Riley H. Hazard, Hafizur R. Chowhury, Nurul Alam, Peter Kim Streafield, Veronica Tallo, Diozele Sanvictores, Marilla Lucero, Tim Adair, Alan D. Lopez

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

Adverse events and nocebo phenomena: treatment or disease specific?

Panagiotis Zis, Panagiota Sykioti

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

The Health Stigma and Discrimination Framework: a global, crosscutting framework to inform research, intervention development, and policy on health-related stigmas

Anne L. Stangl, Valerie A. Earnshaw, Carmen H. Logie, Wim van Brakel, Leickness C. Simbayi, Iman Barré, John F. Dovidio

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

Participatory praxis as an imperative for health-related stigma research

Laurel Sprague, Rima Afifi, George Ayala, Musah Lumumba El-nasoor

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Does regulation increase the rate at which doctors leave practice? Analysis of routine hospital data in the English NHS following the introduction of medical revalidation

Nils Gutacker, Karen Bloor, Chris Bojke, Julian Archer, Kieran Walshe

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

Leukemia relapse after transplantation – a consensus on monitoring, prevention, and treatment in China

Huichun Zhan

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo

Michael Berk, Alyna Turner, Gin S. Malhi, Chee H. Ng, Susan M. Cotton, Seetal Dodd, Yuval Samuni, Michelle Tanious, Claire McAulay, Nathan Dowling, Jerome Sarris, Lauren Owen, Astrid Waterdrinker, Deidre Smith, Olivia M. Dean

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Disaggregating catastrophic health expenditure by disease area: cross-country estimates based on the World Health Surveys

Annie Haakenstad, Matthew Coates, Andrew Marx, Gene Bukhman, Stéphane Verguet

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

High-throughput, non-invasive prenatal testing for fetal rhesus D status in RhD-negative women: a systematic review and meta-analysis

Huiqin Yang, Alexis Llewellyn, Ruth Walker, Melissa Harden, Pedro Saramago, Susan Griffin, Mark Simmonds

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Thymic size is increased by infancy, but not pregnancy, nutritional supplementation in rural Gambian children: a randomized clinical trial

Sophie E. Moore, Anthony J. C. Fulford, Fatou Sosseh, Patrick Nshe, Momodou K. Darboe, Andrew M. Prentice

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Factors associated with requesting and receiving euthanasia: a nationwide mortality follow-back study with a focus on patients with psychiatric disorders, dementia, or an accumulation of health problems related to old age

Kirsten Evenblij, H. Roeline W. Pasman, Agnes van der Heide, Trynke Hoekstra, Bregje D. Onwuteaka-Philipsen

01.12.2019 | Editorial | Ausgabe 1/2019 Open Access

Advancing health equity through cross-cutting approaches to health-related stigma

Gretchen L. Birbeck, Virginia Bond, Valerie Earnshaw, Musah Lumumba El-Nasoor

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A systematic review of multi-level stigma interventions: state of the science and future directions

Deepa Rao, Ahmed Elshafei, Minh Nguyen, Mark L. Hatzenbuehler, Sarah Frey, Vivian F. Go

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury

Yihua Bei, Li-Long Pan, Qiulian Zhou, Cuimei Zhao, Yuan Xie, Chengfei Wu, Xiangmin Meng, Huanyu Gu, Jiahong Xu, Lei Zhou, Joost P. G. Sluijter, Saumya Das, Birgitta Agerberth, Jia Sun, Junjie Xiao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

HBV vaccination and PMTCT as elimination tools in the presence of HIV: insights from a clinical cohort and dynamic model

Anna L. McNaughton, José Lourenço, Louise Hattingh, Emily Adland, Samantha Daniels, Anriette Van Zyl, Connie S. Akiror, Susan Wareing, Katie Jeffery, M. Azim Ansari, Paul Klenerman, Philip J. R. Goulder, Sunetra Gupta, Pieter Jooste, Philippa C. Matthews

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Building a learning community of Australian clinical genomics: a social network study of the Australian Genomic Health Alliance

Janet C. Long, Chiara Pomare, Stephanie Best, Tiffany Boughtwood, Kathryn North, Louise A. Ellis, Kate Churruca, Jeffrey Braithwaite

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Induction and decay of functional complement-fixing antibodies by the RTS,S malaria vaccine in children, and a negative impact of malaria exposure

Liriye Kurtovic, Paul A. Agius, Gaoqian Feng, Damien R. Drew, Itziar Ubillos, Jahit Sacarlal, John J. Aponte, Freya J. I. Fowkes, Carlota Dobaño, James G. Beeson

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Advances in the clinical management of type 2 diabetes: a brief history of the past 15 years and challenges for the future

Naveed Sattar

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

Translational research on reserve against neurodegenerative disease: consensus report of the International Conference on Cognitive Reserve in the Dementias and the Alzheimer’s Association Reserve, Resilience and Protective Factors Professional Interest Area working groups

Robert Perneczky, Gerd Kempermann, Amos D. Korczyn, Fiona E. Matthews, M. Arfan Ikram, Nikolaos Scarmeas, Gael Chetelat, Yaakov Stern, Michael Ewers

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The cost of diagnostic uncertainty: a prospective economic analysis of febrile children attending an NHS emergency department

Simon Leigh, Alison Grant, Nicola Murray, Brian Faragher, Henal Desai, Samantha Dolan, Naeema Cabdi, James B. Murray, Yasmin Rejaei, Stephanie Stewart, Karl Edwardson, Jason Dean, Bimal Mehta, Shunmay Yeung, Frans Coenen, Louis W. Niessen, Enitan D. Carrol

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The effectiveness and cost-effectiveness of strength and balance Exergames to reduce falls risk for people aged 55 years and older in UK assisted living facilities: a multi-centre, cluster randomised controlled trial

Emma K. Stanmore, Alexandra Mavroeidi, Lex D. de Jong, Dawn A. Skelton, Chris J. Sutton, Valerio Benedetto, Luke A. Munford, Wytske Meekes, Vicky Bell, Chris Todd

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Specialist palliative care support is associated with improved pain relief at home during the last 3 months of life in patients with advanced disease: analysis of 5-year data from the national survey of bereaved people (VOICES)

Yousuf ElMokhallalati, Natalie Woodhouse, Tracey Farragher, Michael I. Bennett

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The equity impact of brief opportunistic interventions to promote weight loss in primary care: secondary analysis of the BWeL randomised trial

J. Graham, K. Tudor, S. A. Jebb, A. Lewis, S. Tearne, P. Adab, R. Begh, K. Jolly, A. Daley, A. Farley, D. Lycett, A. Nickless, P. Aveyard

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

What causes severe malaria and its complications in children? Lessons learned over the past 15 years

Andrea L. Conroy, Dibyadyuti Datta, Chandy C. John

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Advanced cell therapeutics are changing the clinical landscape: will mesenchymal stromal cells be a part of it?

Richard Schäfer

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Giving permission to care for people with dementia in residential homes: learning from a realist synthesis of hearing-related communication

Brian Crosbie, Melanie Ferguson, Geoff Wong, Dawn-Marie Walker, Stevie Vanhegan, Tom Dening

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Girl child marriage, socioeconomic status, and undernutrition: evidence from 35 countries in Sub-Saharan Africa

Yvette Efevbera, Jacqueline Bhabha, Paul Farmer, Günther Fink

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature

Igho J. Onakpoya, Carl J. Heneghan, Jeffrey K. Aronson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Characterizing the transitioning epidemiology of herpes simplex virus type 1 in the USA: model-based predictions

Houssein H. Ayoub, Hiam Chemaitelly, Laith J. Abu-Raddad

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Real-time analysis of the diphtheria outbreak in forcibly displaced Myanmar nationals in Bangladesh

Flavio Finger, Sebastian Funk, Kate White, M. Ruby Siddiqui, W. John Edmunds, Adam J. Kucharski

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Quantifying harms to others due to alcohol consumption in Germany: a register-based study

Ludwig Kraus, Nicki-Nils Seitz, Kevin D. Shield, Gerrit Gmel, Jürgen Rehm

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Repeated clinical malaria episodes are associated with modification of the immune system in children

Yaw Bediako, Rhys Adams, Adam J. Reid, John Joseph Valletta, Francis M. Ndungu, Jan Sodenkamp, Jedidah Mwacharo, Joyce Mwongeli Ngoi, Domtila Kimani, Oscar Kai, Juliana Wambua, George Nyangweso, Etienne P. de Villiers, Mandy Sanders, Magda Ewa Lotkowska, Jing-Wen Lin, Sarah Manni, John W. G. Addy, Mario Recker, Chris Newbold, Matthew Berriman, Philip Bejon, Kevin Marsh, Jean Langhorne

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Effect of linoleic acid on ischemic heart disease and its risk factors: a Mendelian randomization study

Jie V. Zhao, C. Mary Schooling

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Digital health at fifteen: more human (more needed)

Kit Huckvale, C. Jason Wang, Azeem Majeed, Josip Car

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cognitive decline and mortality among community-dwelling Chinese older people

Xiaozhen Lv, Wenyuan Li, Yuan Ma, Huashuai Chen, Yi Zeng, Xin Yu, Albert Hofman, Huali Wang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

ApoE4: an emerging therapeutic target for Alzheimer’s disease

Mirna Safieh, Amos D. Korczyn, Daniel M. Michaelson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Comparison of depression prevalence estimates in meta-analyses based on screening tools and rating scales versus diagnostic interviews: a meta-research review

Brooke Levis, Xin Wei Yan, Chen He, Ying Sun, Andrea Benedetti, Brett D. Thombs

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Development and validation of a prognostic model to predict the prognosis of patients who underwent chemotherapy and resection of pancreatic adenocarcinoma: a large international population-based cohort study

Lei Huang, Yesilda Balavarca, Lydia van der Geest, Valery Lemmens, Liesbet Van Eycken, Harlinde De Schutter, Tom B. Johannesen, Vesna Zadnik, Maja Primic-Žakelj, Margit Mägi, Robert Grützmann, Marc G. Besselink, Petra Schrotz-King, Hermann Brenner, Lina Jansen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Comparison of statins for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis

Irene Tramacere, Giorgio B. Boncoraglio, Rita Banzi, Cinzia Del Giovane, Koren H. Kwag, Alessandro Squizzato, Lorenzo Moja

01.12.2019 | Forum | Ausgabe 1/2019 Open Access

‘Fit-for-purpose?’ – challenges and opportunities for applications of blockchain technology in the future of healthcare

Tim K. Mackey, Tsung-Ting Kuo, Basker Gummadi, Kevin A. Clauson, George Church, Dennis Grishin, Kamal Obbad, Robert Barkovich, Maria Palombini

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Profiling the best-performing community medicine distributors for mass drug administration: a comprehensive, data-driven analysis of treatment for schistosomiasis, lymphatic filariasis, and soil-transmitted helminths in Uganda

Goylette F. Chami, Narcis B. Kabatereine, Edridah M. Tukahebwa

01.12.2019 | Guideline | Ausgabe 1/2019 Open Access

Microbiology Investigation Criteria for Reporting Objectively (MICRO): a framework for the reporting and interpretation of clinical microbiology data

Paul Turner, Andrew Fox-Lewis, Poojan Shrestha, David A. B. Dance, Tri Wangrangsimakul, Tomas-Paul Cusack, Clare L. Ling, Jill Hopkins, Tamalee Roberts, Direk Limmathurotsakul, Ben S. Cooper, Susanna Dunachie, Catrin E. Moore, Christiane Dolecek, H. Rogier van Doorn, Philippe J. Guerin, Nicholas P. J. Day, Elizabeth A. Ashley

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Improving engagement with healthcare in hepatitis C: a randomised controlled trial of a peer support intervention

Helen R. Stagg, Julian Surey, Marie Francis, Jennifer MacLellan, Graham R. Foster, André Charlett, Ibrahim Abubakar

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

B-type natriuretic peptide trumps other prognostic markers in patients assessed for coronary disease

Dipak Kotecha, Marcus D. Flather, Dan Atar, Peter Collins, John Pepper, Elizabeth Jenkins, Christopher M. Reid, David Eccleston, on behalf of the Alternative Risk Markers in Coronary Artery Disease (ARM-CAD) Study

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Predicting COPD 1-year mortality using prognostic predictors routinely measured in primary care

C. I. Bloom, F. Ricciardi, L. Smeeth, P. Stone, J. K. Quint

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Relationship between multimorbidity, demographic factors and mortality: findings from the UK Biobank cohort

Bhautesh Dinesh Jani, Peter Hanlon, Barbara I. Nicholl, Ross McQueenie, Katie I. Gallacher, Duncan Lee, Frances S. Mair

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study

Vladeta Ajdacic-Gross, Margot Mutsch, Stephanie Rodgers, Anja Tesic, Mario Müller, Erich Seifritz, En-Young N. Wagner, Roland von Känel, Markus A. Landolt, Nina Steinemann, Viktor von Wyl, Enrique Castelao, Marie-Pierre F. Strippoli, Jennifer Glaus, Caroline Vandeleur, Pedro M. Marques-Vidal, Peter Vollenweider, Martin Preisig

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study

Andrea L. Jorgensen, Clare Prince, Gail Fitzgerald, Anita Hanson, Jennifer Downing, Julia Reynolds, J. Eunice Zhang, Ana Alfirevic, Munir Pirmohamed

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Exploring telomere length in mother–newborn pairs in relation to exposure to multiple toxic metals and potential modifying effects by nutritional factors

Maria Herlin, Karin Broberg, Annachiara Malin Igra, Huiqi Li, Florencia Harari, Marie Vahter

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prospective association between ultra-processed food consumption and incident depressive symptoms in the French NutriNet-Santé cohort

Moufidath Adjibade, Chantal Julia, Benjamin Allès, Mathilde Touvier, Cédric Lemogne, Bernard Srour, Serge Hercberg, Pilar Galan, Karen E. Assmann, Emmanuelle Kesse-Guyot

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study

Andrew P. McGovern, John M. Dennis, Beverley M. Shields, Andrew T. Hattersley, Ewan R. Pearson, Angus G. Jones, On behalf of the MASTERMIND Consortium

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

Data management and sharing policy: the first step towards promoting data sharing

Naomi Waithira, Brian Mutinda, Phaik Yeong Cheah

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Population-level mathematical modeling of antimicrobial resistance: a systematic review

Anna Maria Niewiadomska, Bamini Jayabalasingham, Jessica C. Seidman, Lander Willem, Bryan Grenfell, David Spiro, Cecile Viboud

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Mortality associated with alternative primary healthcare policies: a nationwide microsimulation modelling study in Brazil

Davide Rasella, Thomas Hone, Luis Eugenio de Souza, Renato Tasca, Sanjay Basu, Christopher Millett

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Is resistant hypertension an independent predictor of all-cause mortality in individuals with type 2 diabetes? A prospective cohort study

Anna Solini, Giuseppe Penno, Emanuela Orsi, Enzo Bonora, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Olga Lamacchia, Marco G. Baroni, Antonio Nicolucci, Giuseppe Pugliese, for the Renal Insufficiency And Cardiovascular Events (RIACE) Study Group

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Ethical challenges in global health-related stigma research

Joseph Millum, Megan Campbell, Florencia Luna, Arianne Malekzadeh, Quarraisha Abdool Karim

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Elevated plasma copeptin levels identify the presence and severity of non-alcoholic fatty liver disease in obesity

Ilaria Barchetta, Sofia Enhörning, Flavia Agata Cimini, Danila Capoccia, Caterina Chiappetta, Claudio Di Cristofano, Gianfranco Silecchia, Frida Leonetti, Olle Melander, Maria Gisella Cavallo

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The introduction of ‘No jab, No school’ policy and the refinement of measles immunisation strategies in high-income countries

Filippo Trentini, Piero Poletti, Alessia Melegaro, Stefano Merler

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

DECIDE: a cluster-randomized controlled trial to reduce unnecessary caesarean deliveries in Burkina Faso

Charles Kaboré, Valéry Ridde, Nils Chaillet, Fadima Yaya Bocoum, Ana Pilar Betrán, Alexandre Dumont

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

Knowledge translation in health: how implementation science could contribute more

Michel Wensing, Richard Grol

01.12.2019 | Minireview | Ausgabe 1/2019 Open Access

Vedolizumab trough level monitoring in inflammatory bowel disease: a state-of-the-art overview

Lieven Pouillon, Séverine Vermeire, Peter Bossuyt

01.12.2019 | Minireview | Ausgabe 1/2019 Open Access

Recent advances in triple negative breast cancer: the immunotherapy era

Antonio Marra, Giulia Viale, Giuseppe Curigliano

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Claims of causality in health news: a randomised trial

Rachel C. Adams, Aimée Challenger, Luke Bratton, Jacky Boivin, Lewis Bott, Georgina Powell, Andy Williams, Christopher D. Chambers, Petroc Sumner

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Variation in health system performance for managing diabetes among states in India: a cross-sectional study of individuals aged 15 to 49 years

Jonas Prenissl, Lindsay M. Jaacks, Viswanathan Mohan, Jennifer Manne-Goehler, Justine I. Davies, Ashish Awasthi, Anne Christine Bischops, Rifat Atun, Till Bärnighausen, Sebastian Vollmer, Pascal Geldsetzer

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The classification of feeding and eating disorders in the ICD-11: results of a field study comparing proposed ICD-11 guidelines with existing ICD-10 guidelines

Angélica M. Claudino, Kathleen M. Pike, Phillipa Hay, Jared W. Keeley, Spencer C. Evans, Tahilia J. Rebello, Rachel Bryant-Waugh, Yunfei Dai, Min Zhao, Chihiro Matsumoto, Cecile Rausch Herscovici, Blanca Mellor-Marsá, Anne-Claire Stona, Cary S. Kogan, Howard F. Andrews, Palmiero Monteleone, David Joseph Pilon, Cornelia Thiels, Pratap Sharan, Samir Al-Adawi, Geoffrey M. Reed

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards: a large cohort study

Xia Li, Alexander Ploner, Ida K. Karlsson, Xingrong Liu, Patrik K. E. Magnusson, Nancy L. Pedersen, Sara Hägg, Juulia Jylhävä

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts

Myriam Alexander, A. Katrina Loomis, Johan van der Lei, Talita Duarte-Salles, Daniel Prieto-Alhambra, David Ansell, Alessandro Pasqua, Francesco Lapi, Peter Rijnbeek, Mees Mosseveld, Dawn M. Waterworth, Stuart Kendrick, Naveed Sattar, William Alazawi

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Commentary on a recent article on the effects of the ‘Daily Mile’ on physical activity, fitness and body composition: addressing key limitations

Andy Daly-Smith, Jade L. Morris, Matthew Hobbs, Jim McKenna

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Response to Daly-Smith et al.’s commentary on ‘The Daily Mile makes primary school children more active, less sedentary and improves their fitness and body composition: a quasi-experimental pilot study’

Ross A. Chesham, Josephine N. Booth, Emma L. Sweeney, Gemma C. Ryde, Trish Gorely, Naomi E. Brooks, Colin N. Moran

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria

Andrea L. Conroy, Robert O. Opoka, Paul Bangirana, Richard Idro, John M. Ssenkusu, Dibyadyuti Datta, James S. Hodges, Catherine Morgan, Chandy C. John

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Effects of school neighborhood food environments on childhood obesity at multiple scales: a longitudinal kindergarten cohort study in the USA

Peng Jia, Hong Xue, Xi Cheng, Youfa Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Ethnic differences in prediabetes incidence among immigrants to Canada: a population-based cohort study

Ghazal S. Fazli, Rahim Moineddin, Arlene S. Bierman, Gillian L. Booth

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan: results from the World Mental Health Surveys

Ymkje Anna de Vries, Ali Al-Hamzawi, Jordi Alonso, Guilherme Borges, Ronny Bruffaerts, Brendan Bunting, José Miguel Caldas-de-Almeida, Alfredo H. Cia, Giovanni De Girolamo, Rumyana V. Dinolova, Oluyomi Esan, Silvia Florescu, Oye Gureje, Josep Maria Haro, Chiyi Hu, Elie G. Karam, Aimee Karam, Norito Kawakami, Andrzej Kiejna, Viviane Kovess-Masfety, Sing Lee, Zeina Mneimneh, Fernando Navarro-Mateu, Marina Piazza, Kate Scott, Margreet ten Have, Yolanda Torres, Maria Carmen Viana, Ronald C. Kessler, Peter de Jonge, on behalf of the WHO World Mental Health Survey Collaborators

01.12.2019 | Software | Ausgabe 1/2019 Open Access

An integrated approach to processing WHO-2016 verbal autopsy data: the InterVA-5 model

Peter Byass, Laith Hussain-Alkhateeb, Lucia D’Ambruoso, Samuel Clark, Justine Davies, Edward Fottrell, Jon Bird, Chodziwadziwa Kabudula, Stephen Tollman, Kathleen Kahn, Linus Schiöler, Max Petzold

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The XN-30 hematology analyzer for rapid sensitive detection of malaria: a diagnostic accuracy study

Annelies Post, Berenger Kaboré, Isaie J. Reuling, Joel Bognini, Wouter van der Heijden, Salou Diallo, Palpouguini Lompo, Basile Kam, Natacha Herssens, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein, Halidou Tinto, Jan Jacobs, Quirijn de Mast, Andre J. van der Ven

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Monitoring progress in reducing maternal mortality using verbal autopsy methods in vital registration systems: what can we conclude about specific causes of maternal death?

Ian D. Riley, Riley H. Hazard, Rohina Joshi, Hafizur Rahman Chowdhury, Alan D. Lopez

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Three randomized controlled trials evaluating the impact of “spin” in health news stories reporting studies of pharmacologic treatments on patients’/caregivers’ interpretation of treatment benefit

Isabelle Boutron, Romana Haneef, Amélie Yavchitz, Gabriel Baron, John Novack, Ivan Oransky, Gary Schwitzer, Philippe Ravaud

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Tissue-infiltrating lymphocytes signature predicts survival in patients with early/intermediate stage hepatocellular carcinoma

Meng-Xin Tian, Wei-Ren Liu, Han Wang, Yu-Fu Zhou, Lei Jin, Xi-Fei Jiang, Chen-Yang Tao, Zheng Tang, Pei-Yun Zhou, Yuan Fang, Wei-Feng Qu, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou, Wan Yee Lau, Jia Fan, Ying-Hong Shi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks—results from the Lassa fever pilot

Louise Sigfrid, Catrin Moore, Alex P. Salam, Nicola Maayan, Candyce Hamel, Chantelle Garritty, Vittoria Lutje, Brian Buckley, Karla Soares-Weiser, Rachel Marshall, Mike Clarke, Peter Horby

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Physical activity, multimorbidity, and life expectancy: a UK Biobank longitudinal study

Yogini V. Chudasama, Kamlesh K. Khunti, Francesco Zaccardi, Alex V. Rowlands, Thomas Yates, Clare L. Gillies, Melanie J. Davies, Nafeesa N. Dhalwani

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Performance of the Framingham risk models and pooled cohort equations for predicting 10-year risk of cardiovascular disease: a systematic review and meta-analysis

Johanna A. Damen, Romin Pajouheshnia, Pauline Heus, Karel G. M. Moons, Johannes B. Reitsma, Rob J. P. M. Scholten, Lotty Hooft, Thomas P. A. Debray

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Estimated nationwide impact of implementing a preemptive pharmacogenetic panel approach to guide drug prescribing in primary care in The Netherlands

P. C. D. Bank, J. J. Swen, H. J. Guchelaar

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A multi-centre, UK-based, non-inferiority randomised controlled trial of 4 follow-up assessment methods in stroke survivors

Jonathan Hewitt, Anna Pennington, Alexander Smith, Stephanie Gething, Michelle Price, James White, Richard Dewar, Ben Carter

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The effects of antipsychotic medications on microbiome and weight gain in children and adolescents

Tali Bretler, Hagar Weisberg, Omry Koren, Hadar Neuman

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Defining responders to therapies by a statistical modeling approach applied to randomized clinical trial data

Francesca Bovis, Luca Carmisciano, Alessio Signori, Matteo Pardini, Joshua R. Steinerman, Thomas Li, Aaron P. Tansy, Maria Pia Sormani

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Effect of body mass index on pregnancy outcomes in a freeze-all policy: an analysis of 22,043 first autologous frozen-thawed embryo transfer cycles in China

Jie Zhang, Hongfang Liu, Xiaoyan Mao, Qiuju Chen, Yong Fan, Yitao Xiao, Yun Wang, Yanping Kuang

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

Optimising trial designs to identify appropriate antibiotic treatment durations

Koen B. Pouwels, Mo Yin, Christopher C. Butler, Ben S. Cooper, Sarah Wordsworth, A. Sarah Walker, Julie V. Robotham

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Automated versus physician assignment of cause of death for verbal autopsies: randomized trial of 9374 deaths in 117 villages in India

Prabhat Jha, Dinesh Kumar, Rajesh Dikshit, Atul Budukh, Rehana Begum, Prabha Sati, Patrycja Kolpak, Richard Wen, Shyamsundar J. Raithatha, Utkarsh Shah, Zehang Richard Li, Lukasz Aleksandrowicz, Prakash Shah, Kapila Piyasena, Tyler H. McCormick, Hellen Gelband, Samuel J. Clark

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Postmarketing commitments for novel drugs and biologics approved by the US Food and Drug Administration: a cross-sectional analysis

Joshua D. Wallach, Anita T. Luxkaranayagam, Sanket S. Dhruva, Jennifer E. Miller, Joseph S. Ross

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A scoping review on the roles and tasks of peer reviewers in the manuscript review process in biomedical journals

Ketevan Glonti, Daniel Cauchi, Erik Cobo, Isabelle Boutron, David Moher, Darko Hren

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

HIV epidemiology among female sex workers and their clients in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions

Hiam Chemaitelly, Helen A. Weiss, Clara Calvert, Manale Harfouche, Laith J. Abu-Raddad

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Suicide attempts in US adults with lifetime DSM-5 eating disorders

Tomoko Udo, Sarah Bitley, Carlos M. Grilo

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

DIABRISK-SL trial: further consideration of age and impact of imputations

Efstathia Gkioni, Ketevan Glonti, Susanna Dodd, Carrol Gamble

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration

Kirsty A. Houston, Jack Gibb, Peter Olupot-Olupot, Nchafatso Obonyo, Ayub Mpoya, Margaret Nakuya, Rita Muhindo, Sophie Uyoga, Jennifer A. Evans, Roisin Connon, Diana M. Gibb, Elizabeth C. George, Kathryn Maitland

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

Assessing the disease burden of non-alcoholic fatty liver disease in the real world – big data and big numbers

Jörn M. Schattenberg, Mattias Ekstedt

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Observational study: 27 years of severe malaria surveillance in Kilifi, Kenya

Patricia Njuguna, Kathryn Maitland, Amek Nyaguara, Daniel Mwanga, Polycarp Mogeni, Neema Mturi, Shebe Mohammed, Gabriel Mwambingu, Caroline Ngetsa, Kenedy Awuondo, Brett Lowe, Ifedayo Adetifa, J. Anthony G. Scott, Thomas N. Williams, Sarah Atkinson, Faith Osier, Robert W. Snow, Kevin Marsh, Benjamin Tsofa, Norbert Peshu, Mainga Hamaluba, James A. Berkley, Charles R. J. Newton, John Fondo, Anisa Omar, Philip Bejon

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Landmark models to define the age-adjusted risk of developing stage 1 type 1 diabetes across childhood and adolescence

Verena Sophia Hoffmann, Andreas Weiß, Christiane Winkler, Annette Knopff, Manja Jolink, Ezio Bonifacio, Anette-G. Ziegler

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

The TABLET trial: limitations and implications

Chrysoula Dosiou, Alex Stagnaro-Green

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Medication management support in diabetes: a systematic assessment of diabetes self-management apps

Zhilian Huang, Elaine Lum, Geronimo Jimenez, Monika Semwal, Peter Sloot, Josip Car

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Tobacco smoking and risk of 36 cardiovascular disease subtypes: fatal and non-fatal outcomes in a large prospective Australian study

Emily Banks, Grace Joshy, Rosemary J. Korda, Bill Stavreski, Kay Soga, Sam Egger, Cathy Day, Naomi E. Clarke, Sarah Lewington, Alan D. Lopez

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The global impact and cost-effectiveness of a melioidosis vaccine

Nantasit Luangasanatip, Stefan Flasche, David A. B. Dance, Direk Limmathurotsakul, Bart J. Currie, Chiranjay Mukhopadhyay, Tim Atkins, Richard Titball, Mark Jit

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Hospitalisation rates and predictors in people with dementia: a systematic review and meta-analysis

Hilary Shepherd, Gill Livingston, Justin Chan, Andrew Sommerlad

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

Validations of verbal autopsies – comment on ‘automated versus physician assignment of cause of death for verbal autopsies: randomized trial of 9374 deaths in 117 villages in India’

Michel Garenne

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Next-generation sequencing identifies monogenic diabetes in 16% of patients with late adolescence/adult-onset diabetes selected on a clinical basis: a cross-sectional analysis

Xavier Donath, Cécile Saint-Martin, Danièle Dubois-Laforgue, Ramanan Rajasingham, François Mifsud, Cécile Ciangura, José Timsit, Christine Bellanné-Chantelot, on behalf of the Monogenic Diabetes Study Group of the Société Francophone du Diabète

01.12.2019 | Debate | Ausgabe 1/2019 Open Access

Why we need a small data paradigm

Eric B. Hekler, Predrag Klasnja, Guillaume Chevance, Natalie M. Golaszewski, Dana Lewis, Ida Sim

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The uncertainty with using risk prediction models for individual decision making: an exemplar cohort study examining the prediction of cardiovascular disease in English primary care

Alexander Pate, Richard Emsley, Darren M. Ashcroft, Benjamin Brown, Tjeerd van Staa

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network

Bahram Namjou, Todd Lingren, Yongbo Huang, Sreeja Parameswaran, Beth L. Cobb, Ian B. Stanaway, John J. Connolly, Frank D. Mentch, Barbara Benoit, Xinnan Niu, Wei-Qi Wei, Robert J. Carroll, Jennifer A. Pacheco, Isaac T. W. Harley, Senad Divanovic, David S. Carrell, Eric B. Larson, David J. Carey, Shefali Verma, Marylyn D. Ritchie, Ali G. Gharavi, Shawn Murphy, Marc S. Williams, David R. Crosslin, Gail P. Jarvik, Iftikhar J. Kullo, Hakon Hakonarson, Rongling Li, Stavra A. Xanthakos, John B. Harley, The eMERGE Network

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Sex differences in the association between diabetes and risk of cardiovascular disease, cancer, and all-cause and cause-specific mortality: a systematic review and meta-analysis of 5,162,654 participants

Yafeng Wang, Adrienne O’Neil, Yurui Jiao, Lijun Wang, Jingxin Huang, Yutao Lan, Yikun Zhu, Chuanhua Yu

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

Building the case for actionable ethics in digital health research supported by artificial intelligence

Camille Nebeker, John Torous, Rebecca J. Bartlett Ellis

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Delirium detection in older acute medical inpatients: a multicentre prospective comparative diagnostic test accuracy study of the 4AT and the confusion assessment method

Susan D. Shenkin, Christopher Fox, Mary Godfrey, Najma Siddiqi, Steve Goodacre, John Young, Atul Anand, Alasdair Gray, Janet Hanley, Allan MacRaild, Jill Steven, Polly L. Black, Zoë Tieges, Julia Boyd, Jacqueline Stephen, Christopher J. Weir, Alasdair M. J. MacLullich

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Health professions digital education on clinical practice guidelines: a systematic review by Digital Health Education collaboration

Lorainne Tudor Car, Aijia Soong, Bhone Myint Kyaw, Kee Leng Chua, Naomi Low-Beer, Azeem Majeed

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Distinct mortality patterns at 0–2 days versus the remaining neonatal period: results from population-based assessment in the Indian state of Bihar

Rakhi Dandona, G. Anil Kumar, Debarshi Bhattacharya, Md. Akbar, Yamini Atmavilas, Priya Nanda, Lalit Dandona

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Low serum IGF1 is associated with hypertension and predicts early cardiovascular events in women with rheumatoid arthritis

Malin C. Erlandsson, Lovisa Lyngfelt, N. David Åberg, Caroline Wasén, Rachelle A. Espino, Sofia Töyrä Silfverswärd, Mitra Nadali, Katharina Jood, Karin M.E. Andersson, Rille Pullerits, Maria I. Bokarewa

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Celiac disease: a comprehensive current review

Giacomo Caio, Umberto Volta, Anna Sapone, Daniel A. Leffler, Roberto De Giorgio, Carlo Catassi, Alessio Fasano

01.12.2019 | Editorial | Ausgabe 1/2019 Open Access

Beyond the hype of big data and artificial intelligence: building foundations for knowledge and wisdom

Josip Car, Aziz Sheikh, Paul Wicks, Marc S. Williams

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: How can clinicians, specialty societies and others evaluate and improve the quality of apps for patient use?

Jeremy C. Wyatt

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort

Magdalena Nowakowska, Salwa S. Zghebi, Darren M. Ashcroft, Iain Buchan, Carolyn Chew-Graham, Tim Holt, Christian Mallen, Harm Van Marwijk, Niels Peek, Rafael Perera-Salazar, David Reeves, Martin K. Rutter, Stephen F. Weng, Nadeem Qureshi, Mamas A. Mamas, Evangelos Kontopantelis

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Antenatal iron supplementation and birth weight in conditions of high exposure to infectious diseases

Hans Verhoef, Martin N. Mwangi, Carla Cerami, Andrew M. Prentice

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Three randomized controlled trials evaluating the impact of “spin” in health news stories reporting studies of pharmacologic treatments on patients’/caregivers’ interpretation of treatment benefit

Isabelle Boutron, Romana Haneef, Amélie Yavchitz, Gabriel Baron, John Novack, Ivan Oransky, Gary Schwitzer, Philippe Ravaud

01.12.2019 | Forum | Ausgabe 1/2019 Open Access

Current opportunities to catalyze research in nutrition and cancer prevention – an interdisciplinary perspective

The Cancer Research UK - Ludwig Cancer Research Nutrition and Cancer Prevention Collaborative Group

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Mortality following myocardial infarction among HIV-infected persons: the Center for AIDS Research Network Of Integrated Clinical Systems (CNICS)

Matthew J. Feinstein, Robin M. Nance, J. A. Chris Delaney, Susan R. Heckbert, Matthew J. Budoff, Daniel R. Drozd, Greer A. Burkholder, James H. Willig, Michael J. Mugavero, William C. Mathews, Richard D. Moore, Joseph J. Eron, Sonia Napravnik, Peter W. Hunt, Elvin Geng, Priscilla Hsue, Inga Peter, William B. Lober, Kristina Crothers, Carl Grunfeld, Michael S. Saag, Mari M. Kitahata, Donald M. Lloyd-Jones, Heidi M. Crane

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The long-term survival characteristics of a cohort of colorectal cancer patients and baseline variables associated with survival outcomes with or without time-varying effects

Yajun Yu, Megan Carey, William Pollett, Jane Green, Elizabeth Dicks, Patrick Parfrey, Yildiz E. Yilmaz, Sevtap Savas

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis

Robert J. Commons, Julie A. Simpson, Kamala Thriemer, Cindy S. Chu, Nicholas M. Douglas, Tesfay Abreha, Sisay G. Alemu, Arletta Añez, Nicholas M. Anstey, Abraham Aseffa, Ashenafi Assefa, Ghulam R. Awab, J. Kevin Baird, Bridget E. Barber, Isabelle Borghini-Fuhrer, Umberto D’Alessandro, Prabin Dahal, André Daher, Peter J. de Vries, Annette Erhart, Margarete S. M. Gomes, Matthew J. Grigg, Jimee Hwang, Piet A. Kager, Tsige Ketema, Wasif A. Khan, Marcus V. G. Lacerda, Toby Leslie, Benedikt Ley, Kartini Lidia, Wuelton M. Monteiro, Dhelio B. Pereira, Giao T. Phan, Aung P. Phyo, Mark Rowland, Kavitha Saravu, Carol H. Sibley, André M. Siqueira, Kasia Stepniewska, Walter R. J. Taylor, Guy Thwaites, Binh Q. Tran, Tran T. Hien, José Luiz F. Vieira, Sonam Wangchuk, James Watson, Timothy William, Charles J. Woodrow, Francois Nosten, Philippe J. Guerin, Nicholas J. White, Ric N. Price

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

When to keep it simple – adaptive designs are not always useful

James M. S. Wason, Peter Brocklehurst, Christina Yap

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Understanding the interactions between iron supplementation, infectious disease and adverse birth outcomes is essential to guide public health recommendations

Freya J. I. Fowkes, Eliza Davidson, Paul A. Agius, James G. Beeson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study

Alyshah Abdul Sultan, Christian Mallen, Sara Muller, Samantha Hider, Ian Scott, Toby Helliwell, Lindsay J. Hall

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Informing decision-making for universal access to quality tuberculosis diagnosis in India: an economic-epidemiological model

Hojoon Sohn, Parastu Kasaie, Emily Kendall, Gabriela B. Gomez, Anna Vassall, Madhukar Pai, David Dowdy

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Two dose levels of rabbit antithymocyte globulin as graft-versus-host disease prophylaxis in haploidentical stem cell transplantation: a multicenter randomized study

Ren Lin, Yu Wang, Fen Huang, Zhiping Fan, Shen Zhang, Ting Yang, Yajing Xu, Na Xu, Li Xuan, Jieyu Ye, Jing Sun, Xiaojun Huang, Qifa Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

RTS,S/AS01E immunization increases antibody responses to vaccine-unrelated Plasmodium falciparum antigens associated with protection against clinical malaria in African children: a case-control study

Carlota Dobaño, Itziar Ubillos, Chenjerai Jairoce, Ben Gyan, Marta Vidal, Alfons Jiménez, Rebeca Santano, David Dosoo, Augusto J. Nhabomba, Aintzane Ayestaran, Ruth Aguilar, Nana Aba Williams, Núria Díez-Padrisa, David Lanar, Virander Chauhan, Chetan Chitnis, Sheetij Dutta, Deepak Gaur, Evelina Angov, Kwaku Poku Asante, Seth Owusu-Agyei, Clarissa Valim, Benoit Gamain, Ross L. Coppel, David Cavanagh, James G. Beeson, Joseph J. Campo, Gemma Moncunill

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: The uncertainty with using risk prediction models for individual decision making: an exemplar cohort study examining the prediction of cardiovascular disease in English primary care

Alexander Pate, Richard Emsley, Darren M. Ashcroft, Benjamin Brown, Tjeerd van Staa

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

New approaches for detecting cancer with circulating cell-free DNA

Clare Fiala, Eleftherios P. Diamandis

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults

Tao Huang, Shoaib Afzal, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Iona Y. Millwood, Robin G. Walters, Yiping Chen, Ningyu Chen, Ruqin Gao, Junshi Chen, Robert Clarke, Zhengming Chen, Christina Ellervik, Børge G. Nordestgaard, Jun Lv, Liming Li, on behalf of the China Kadoorie Biobank Collaborative Group

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Clinical and cost-effectiveness of contingency management for cannabis use in early psychosis: the CIRCLE randomised clinical trial

Luke Sheridan Rains, Louise Marston, Mark Hinton, Steven Marwaha, Thomas Craig, David Fowler, Michael King, Rumana Z. Omar, Paul McCrone, Jonathan Spencer, Joanne Taylor, Sophie Colman, Catherine Harder, Eleanor Gilbert, Amie Randhawa, Kirsty Labuschagne, Charlotte Jones, Theodora Stefanidou, Marina Christoforou, Meghan Craig, John Strang, Tim Weaver, Sonia Johnson

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Reducing the incidence of predictors of cardio-metabolic disease and dysglycaemia with lifestyle modification in at-risk persons – results of further analyses of DIABRISK-SL in those below 18 years of age

Nikolaos Fountoulakis, Mahen Wijesuriya, Luigi Gnudi, Martin Gulliford, Janaka Karalliedde

01.12.2019 | Guideline | Ausgabe 1/2019 Open Access

Guidelines for multi-model comparisons of the impact of infectious disease interventions

Saskia den Boon, Mark Jit, Marc Brisson, Graham Medley, Philippe Beutels, Richard White, Stefan Flasche, T. Déirdre Hollingsworth, Tini Garske, Virginia E. Pitzer, Martine Hoogendoorn, Oliver Geffen, Andrew Clark, Jane Kim, Raymond Hutubessy

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A novel sub-epidemic modeling framework for short-term forecasting epidemic waves

Gerardo Chowell, Amna Tariq, James M. Hyman

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Persistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes

Paul M. McKeigue, Athina Spiliopoulou, Stuart McGurnaghan, Marco Colombo, Luke Blackbourn, Timothy J. McDonald, Suna Onengut-Gomuscu, Stephen S. Rich, Colin N. A. Palmer, John A. McKnight, Mark W. J. Strachan, Alan W. Patrick, John Chalmers, Robert S. Lindsay, John R. Petrie, Sandeep Thekkepat, Andrew Collier, Sandra MacRury, Helen M. Colhoun

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

Gene–environment interactions and vitamin D effects on cardiovascular risk

Guido Iaccarino, Bruno Trimarco

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Trends of blood pressure and heart rate in normal pregnancies: a systematic review and meta-analysis

Lise Loerup, Rebecca M. Pullon, Jacqueline Birks, Susannah Fleming, Lucy H. Mackillop, Stephen Gerry, Peter J. Watkinson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Dissecting genetic factors affecting phenylephrine infusion rates during anesthesia: a genome-wide association study employing EHR data

Yanfei Zhang, S. Mark Poler, Jiang Li, Vida Abedi, Sarah A. Pendergrass, Marc S. Williams, Ming Ta Michael Lee

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

‘Caveat emptor’: the cautionary tale of endocarditis and the potential pitfalls of clinical coding data—an electronic health records study

Nicola Fawcett, Bernadette Young, Leon Peto, T. Phuong Quan, Richard Gillott, Jianhua Wu, Chris Middlemass, Sheila Weston, Derrick W. Crook, Tim E. A. Peto, Berit Muller-Pebody, Alan P. Johnson, A. Sarah Walker, Jonathan A. T. Sandoe

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A systematic review of clinical guidelines on the management of acute, community-acquired CNS infections

Louise Sigfrid, Chelsea Perfect, Amanda Rojek, Kajsa-Stina Longuere, Sam Lipworth, Eli Harriss, James Lee, Alex Salam, Gail Carson, Herman Goossens, Peter Horby

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A dynamic neural network model for predicting risk of Zika in real time

Mahmood Akhtar, Moritz U. G. Kraemer, Lauren M. Gardner

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Estimating the burden of dengue and the impact of release of wMel Wolbachia-infected mosquitoes in Indonesia: a modelling study

Kathleen M. O’Reilly, Emilie Hendrickx, Dinar D. Kharisma, Nandyan N. Wilastonegoro, Lauren B. Carrington, Iqbal R. F. Elyazar, Adam J. Kucharski, Rachel Lowe, Stefan Flasche, David M. Pigott, Robert C. Reiner Jr, W. John Edmunds, Simon I. Hay, Laith Yakob, Donald S. Shepard, Oliver J. Brady

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

The implications of three major new trials for the effect of water, sanitation and hygiene on childhood diarrhea and stunting: a consensus statement

Oliver Cumming, Benjamin F. Arnold, Radu Ban, Thomas Clasen, Joanna Esteves Mills, Matthew C. Freeman, Bruce Gordon, Raymond Guiteras, Guy Howard, Paul R. Hunter, Richard B. Johnston, Amy J. Pickering, Andrew J. Prendergast, Annette Prüss-Ustün, Jan Willem Rosenboom, Dean Spears, Shelly Sundberg, Jennyfer Wolf, Clair Null, Stephen P. Luby, Jean H. Humphrey, John M. Colford Jr.

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Vibration of effects from diverse inclusion/exclusion criteria and analytical choices: 9216 different ways to perform an indirect comparison meta-analysis

Clément Palpacuer, Karima Hammas, Renan Duprez, Bruno Laviolle, John P. A. Ioannidis, Florian Naudet

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The case for a universal hepatitis C vaccine to achieve hepatitis C elimination

Nick Scott, David P. Wilson, Alexander J. Thompson, Eleanor Barnes, Manal El-Sayed, Adele Schwartz Benzaken, Heidi E. Drummer, Margaret E. Hellard

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

Surveillance and monitoring of antimicrobial resistance: limitations and lessons from the GRAM project

Jesse Schnall, Arjun Rajkhowa, Kevin Ikuta, Puja Rao, Catrin E. Moore

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Fifteen years of epidemiology in BMC Medicine

Deborah A. Lawlor

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prospective analysis of circulating metabolites and breast cancer in EPIC

Mathilde His, Vivian Viallon, Laure Dossus, Audrey Gicquiau, David Achaintre, Augustin Scalbert, Pietro Ferrari, Isabelle Romieu, N. Charlotte Onland-Moret, Elisabete Weiderpass, Christina C. Dahm, Kim Overvad, Anja Olsen, Anne Tjønneland, Agnès Fournier, Joseph A. Rothwell, Gianluca Severi, Tilman Kühn, Renée T. Fortner, Heiner Boeing, Antonia Trichopoulou, Anna Karakatsani, Georgia Martimianaki, Giovanna Masala, Sabina Sieri, Rosario Tumino, Paolo Vineis, Salvatore Panico, Carla H. van Gils, Therese H. Nøst, Torkjel M. Sandanger, Guri Skeie, J. Ramón Quirós, Antonio Agudo, Maria-Jose Sánchez, Pilar Amiano, José María Huerta, Eva Ardanaz, Julie A. Schmidt, Ruth C. Travis, Elio Riboli, Konstantinos K. Tsilidis, Sofia Christakoudi, Marc J. Gunter, Sabina Rinaldi

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

C-peptide persistence in type 1 diabetes: ‘not drowning, but waving’?

R. David Leslie, Tanwi Vartak

01.12.2019 | Research Article | Ausgabe 1/2019 Open Access

Combining serological and contact data to derive target immunity levels for achieving and maintaining measles elimination

Sebastian Funk, Jennifer K. Knapp, Emmaculate Lebo, Susan E. Reef, Alya J. Dabbagh, Katrina Kretsinger, Mark Jit, W. John Edmunds, Peter M. Strebel

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Environmental enteric dysfunction: a review of potential mechanisms, consequences and management strategies

Kirkby D. Tickell, Hannah E. Atlas, Judd L. Walson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The VENUSS prognostic model to predict disease recurrence following surgery for non-metastatic papillary renal cell carcinoma: development and evaluation using the ASSURE prospective clinical trial cohort

Tobias Klatte, Kevin M. Gallagher, Luca Afferi, Alessandro Volpe, Nils Kroeger, Silvia Ribback, Alan McNeill, Antony C. P. Riddick, James N. Armitage, Tevita F. ‘Aho, Tim Eisen, Kate Fife, Axel Bex, Allan J. Pantuck, Grant D. Stewart

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

Response to ‘The implications of three major new trials for the effect of water, sanitation and hygiene on childhood diarrhea and stunting: a consensus statement’ by Cumming et al.

Megan Wilson-Jones, Kyla Smith, Dan Jones, Helen Hamilton, Leah Richardson, Alison Macintyre, Om Prasad Gautam, Erik Harvey, Henry Northover

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Tracking pregnant women displacements in Sao Paulo, Brazil: a complex systems approach to regionalization through the emergence of patterns

Felix Rigoli, Sergio Mascarenhas, Domingos Alves, Tiago Canelas, Geraldo Duarte

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Comparing the prognostic value of geriatric health indicators: a population-based study

Alberto Zucchelli, Davide L. Vetrano, Giulia Grande, Amaia Calderón-Larrañaga, Laura Fratiglioni, Alessandra Marengoni, Debora Rizzuto

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Customized versus population birth weight charts for identification of newborns at risk of long-term adverse cardio-metabolic and respiratory outcomes: a population-based prospective cohort study

Jan S. Erkamp, Vincent W. V. Jaddoe, Annemarie G. M. G. J. Mulders, Eric A. P. Steegers, Irwin K. M. Reiss, Liesbeth Duijts, Romy Gaillard

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Psychological primitives can make sense of biopsychosocial factor complexity in psychopathology

Joseph C. Franklin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Age-treatment subgroup analyses in Cochrane intervention reviews: a meta-epidemiological study

Patrick Liu, John P. A. Ioannidis, Joseph S. Ross, Sanket S. Dhruva, Anita T. Luxkaranayagam, Vasilis Vasiliou, Joshua D. Wallach

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

Adaptive trials, efficiency, and ethics

Spencer Phillips Hey

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Development and validation of a novel MR imaging predictor of response to induction chemotherapy in locoregionally advanced nasopharyngeal cancer: a randomized controlled trial substudy (NCT01245959)

Di Dong, Fan Zhang, Lian-Zhen Zhong, Meng-Jie Fang, Cheng-Long Huang, Ji-Jin Yao, Ying Sun, Jie Tian, Jun Ma, Ling-Long Tang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Socioeconomic status and stroke incidence, prevalence, mortality, and worldwide burden: an ecological analysis from the Global Burden of Disease Study 2017

Abolfazl Avan, Hadi Digaleh, Mario Di Napoli, Saverio Stranges, Reza Behrouz, Golnaz Shojaeianbabaei, Amin Amiri, Reza Tabrizi, Naghmeh Mokhber, J. David Spence, Mahmoud Reza Azarpazhooh

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

Three myths about risk thresholds for prediction models

Laure Wynants, Maarten van Smeden, David J. McLernon, Dirk Timmerman, Ewout W. Steyerberg, Ben Van Calster, on behalf of the Topic Group ‘Evaluating diagnostic tests and prediction models’ of the STRATOS initiative

01.12.2019 | Correspondence | Ausgabe 1/2019 Open Access

Interventions to prevent, delay or reverse frailty in older people: a journey towards clinical guidelines

Maura Marcucci, Sarah Damanti, Federico Germini, Joao Apostolo, Elzbieta Bobrowicz-Campos, Holly Gwyther, Carol Holland, Donata Kurpas, Maria Bujnowska-Fedak, Katarzyna Szwamel, Silvina Santana, Alessandro Nobili, Barbara D’Avanzo, Antonio Cano

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

Cannabis use in first episode psychosis: what we have tried and why it hasn’t worked

Michael G. McDonell, Oladunni Oluwoye

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

Key challenges for delivering clinical impact with artificial intelligence

Christopher J. Kelly, Alan Karthikesalingam, Mustafa Suleyman, Greg Corrado, Dominic King

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: a follow-up study from a randomized controlled trial (FASSTT Offspring Trial)

Helene McNulty, Mark Rollins, Tony Cassidy, Aoife Caffrey, Barry Marshall, James Dornan, Marian McLaughlin, Breige A. McNulty, Mary Ward, J. J. Strain, Anne M. Molloy, Diane J. Lees-Murdock, Colum P. Walsh, Kristina Pentieva

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

Does low-density lipoprotein cholesterol induce inflammation? If so, does it matter? Current insights and future perspectives for novel therapies

Ruurt A. Jukema, Tarek A. N. Ahmed, Jean-Claude Tardif

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups

Georg Gelbenegger, Marek Postula, Ladislav Pecen, Sigrun Halvorsen, Maciej Lesiak, Christian Schoergenhofer, Bernd Jilma, Christian Hengstenberg, Jolanta M. Siller-Matula

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Growth faltering is associated with altered brain functional connectivity and cognitive outcomes in urban Bangladeshi children exposed to early adversity

Wanze Xie, Sarah K. G. Jensen, Mark Wade, Swapna Kumar, Alissa Westerlund, Shahria H. Kakon, Rashidul Haque, William A. Petri, Charles A. Nelson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann–Pick diseases

Mark L. Schultz, Maria V. Fawaz, Ruth D. Azaria, Todd C. Hollon, Elaine A. Liu, Thaddeus J. Kunkel, Troy A. Halseth, Kelsey L. Krus, Ran Ming, Emily E. Morin, Hayley S. McLoughlin, David D. Bushart, Henry L. Paulson, Vikram G. Shakkottai, Daniel A. Orringer, Anna S. Schwendeman, Andrew P. Lieberman

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Representation of people with comorbidity and multimorbidity in clinical trials of novel drug therapies: an individual-level participant data analysis

Peter Hanlon, Laurie Hannigan, Jesus Rodriguez-Perez, Colin Fischbacher, Nicky J. Welton, Sofia Dias, Frances S. Mair, Bruce Guthrie, Sarah Wild, David A. McAllister

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: a cohort study of 337,148 in vitro fertilisation cycles

Andrew D. A. C. Smith, Kate Tilling, Deborah A. Lawlor, Scott M. Nelson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Unravelling the complex nature of resilience factors and their changes between early and later adolescence

J. Fritz, J. Stochl, E. I. Fried, I. M. Goodyer, C. D. van Borkulo, P. O. Wilkinson, A.-L. van Harmelen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis

Shu-zhen Zhang, Qin-qin Wang, Qiao-qiao Yang, Huan-yu Gu, Yan-qing Yin, Yan-dong Li, Jin-can Hou, Rong Chen, Qing-qing Sun, Ying-feng Sun, Gang Hu, Jia-wei Zhou

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Accuracy in detecting inadequate research reporting by early career peer reviewers using an online CONSORT-based peer-review tool (COBPeer) versus the usual peer-review process: a cross-sectional diagnostic study

Anthony Chauvin, Philippe Ravaud, David Moher, David Schriger, Sally Hopewell, Daniel Shanahan, Sabina Alam, Gabriel Baron, Jean-Philippe Regnaux, Perrine Crequit, Valeria Martinez, Carolina Riveros, Laurence Le Cleach, Alessandro Recchioni, Douglas G. Altman, Isabelle Boutron

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis

Laura Pasea, Sheng-Chia Chung, Mar Pujades-Rodriguez, Anoop D. Shah, Samantha Alvarez-Madrazo, Victoria Allan, James T. Teo, Daniel Bean, Reecha Sofat, Richard Dobson, Amitava Banerjee, Riyaz S. Patel, Adam Timmis, Spiros Denaxas, Harry Hemingway

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Validation of the AJCC prognostic stage for HER2-positive breast cancer in the ShortHER trial

Maria Vittoria Dieci, Giancarlo Bisagni, Alba A. Brandes, Antonio Frassoldati, Luigi Cavanna, Francesco Giotta, Michele Aieta, Vittorio Gebbia, Antonino Musolino, Ornella Garrone, Michela Donadio, Anita Rimanti, Alessandra Beano, Claudio Zamagni, Hector Soto Parra, Federico Piacentini, Saverio Danese, Antonella Ferro, Katia Cagossi, Samanta Sarti, Anna Rita Gambaro, Sante Romito, Viviana Bazan, Laura Amaducci, Gabriella Moretti, Maria Pia Foschini, Sara Balduzzi, Roberto Vicini, Roberto D’Amico, Gaia Griguolo, Valentina Guarneri, Pier Franco Conte

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Profiling Mycobacterium tuberculosis transmission and the resulting disease burden in the five highest tuberculosis burden countries

Romain Ragonnet, James M. Trauer, Nicholas Geard, Nick Scott, Emma S. McBryde

01.12.2019 | Opinion | Ausgabe 1/2019 Open Access

Challenges in management and prevention of ischemic heart disease in low socioeconomic status people in LLMICs

Rajeev Gupta, Salim Yusuf

01.12.2019 | Editorial | Ausgabe 1/2019 Open Access

Tackling the triple threats of childhood malnutrition

Martha Mwangome, Andrew M. Prentice

01.12.2019 | Research Article | Ausgabe 1/2019 Open Access

Engagement, not personal characteristics, was associated with the seriousness of regulatory adjudication decisions about physicians: a cross-sectional study

Javier A. Caballero, Steve P. Brown

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The epidemiological burden of obesity in childhood: a worldwide epidemic requiring urgent action

Mariachiara Di Cesare, Maroje Sorić, Pascal Bovet, J Jaime Miranda, Zulfiqar Bhutta, Gretchen A Stevens, Avula Laxmaiah, Andre-Pascal Kengne, James Bentham

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Can public health policies on alcohol and tobacco reduce a cancer epidemic? Australia's experience

Heng Jiang, Michael Livingston, Robin Room, Yong Gan, Dallas English, Richard Chenhall

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Determinants of linear growth faltering among children with moderate-to-severe diarrhea in the Global Enteric Multicenter Study

Rebecca L. Brander, Patricia B. Pavlinac, Judd L. Walson, Grace C. John-Stewart, Marcia R. Weaver, Abu S. G. Faruque, Anita K. M. Zaidi, Dipika Sur, Samba O. Sow, M. Jahangir Hossain, Pedro L. Alonso, Robert F. Breiman, Dilruba Nasrin, James P. Nataro, Myron M. Levine, Karen L. Kotloff

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Body composition of children with moderate and severe undernutrition and after treatment: a narrative review

Jonathan C. K. Wells

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

In utero exposure to mercury and childhood overweight or obesity: counteracting effect of maternal folate status

Guoying Wang, Jessica DiBari, Eric Bind, Andrew M. Steffens, Jhindan Mukherjee, Tami R. Bartell, David C. Bellinger, Xiumei Hong, Yuelong Ji, Mei-Cheng Wang, Marsha Wills-Karp, Tina L. Cheng, Xiaobin Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Insulin resistance and systemic metabolic changes in oral glucose tolerance test in 5340 individuals: an interventional study

Qin Wang, Jari Jokelainen, Juha Auvinen, Katri Puukka, Sirkka Keinänen-Kiukaanniemi, Marjo-Riitta Järvelin, Johannes Kettunen, Ville-Petteri Mäkinen, Mika Ala-Korpela

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The quality of preventive care for pre-school aged children in Australian general practice

Louise K. Wiles, Carl de Wet, Chris Dalton, Elisabeth Murphy, Mark F. Harris, Peter D. Hibbert, Charlotte J. Molloy, Gaston Arnolda, Hsuen P. Ting, Jeffrey Braithwaite, on behalf of the CareTrack Kids Investigative Team

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Determinants of high residual post-PCV13 pneumococcal vaccine-type carriage in Blantyre, Malawi: a modelling study

J. Lourenço, U. Obolski, T. D. Swarthout, A. Gori, N. Bar-Zeev, D. Everett, A. W. Kamng’ona, T. S. Mwalukomo, A. A. Mataya, C. Mwansambo, M. Banda, S. Gupta, N. French, R. S. Heyderman

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Differential impact of malaria control interventions on P. falciparum and P. vivax infections in young Papua New Guinean children

Maria Ome-Kaius, Johanna Helena Kattenberg, Sophie Zaloumis, Matthew Siba, Benson Kiniboro, Shadrach Jally, Zahra Razook, Daisy Mantila, Desmond Sui, Jason Ginny, Anna Rosanas-Urgell, Stephan Karl, Thomas Obadia, Alyssa Barry, Stephen J. Rogerson, Moses Laman, Daniel Tisch, Ingrid Felger, James W. Kazura, Ivo Mueller, Leanne J. Robinson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and risk of in situ breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Nena Karavasiloglou, Anika Hüsing, Giovanna Masala, Carla H. van Gils, Renée Turzanski Fortner, Jenny Chang-Claude, Inge Huybrechts, Elisabete Weiderpass, Marc Gunter, Patrick Arveux, Agnès Fournier, Marina Kvaskoff, Anne Tjønneland, Cecilie Kyrø, Christina C. Dahm, Helene Tilma Vistisen, Marije F. Bakker, Maria-Jose Sánchez, María Dolores Chirlaque López, Carmen Santiuste, Eva Ardanaz, Virginia Menéndez, Antonio Agudo, Antonia Trichopoulou, Anna Karakatsani, Carlo La Vecchia, Eleni Peppa, Domenico Palli, Claudia Agnoli, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Salma Tunå Butt, Signe Borgquist, Guri Skeie, Matthias Schulze, Timothy Key, Kay-Tee Khaw, Kostantinos K. Tsilidis, Merete Ellingjord-Dale, Elio Riboli, Rudolf Kaaks, Laure Dossus, Sabine Rohrmann, Tilman Kühn

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Determinants and extent of weight recording in UK primary care: an analysis of 5 million adults’ electronic health records from 2000 to 2017

B. D. Nicholson, P. Aveyard, C. R. Bankhead, W. Hamilton, F. D. R. Hobbs, S. Lay-Flurrie

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Therapeutic effect of nanoliposomal PCSK9 vaccine in a mouse model of atherosclerosis

Amir Abbas Momtazi-Borojeni, Mahmoud Reza Jaafari, Ali Badiee, Maciej Banach, Amirhossein Sahebkar

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

Economic analyses to inform public health decision-making for tuberculosis: the role of understanding implementation

Priya B. Shete, James G. Kahn

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Causal association of type 2 diabetes with amyotrophic lateral sclerosis: new evidence from Mendelian randomization using GWAS summary statistics

Ping Zeng, Ting Wang, Junnian Zheng, Xiang Zhou

01.12.2019 | Debate | Ausgabe 1/2019 Open Access

Regulating digital health technologies with transparency: the case for dynamic and multi-stakeholder evaluation

Elena Rodriguez-Villa, John Torous

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Patterns of symptoms before a diagnosis of first episode psychosis: a latent class analysis of UK primary care electronic health records

Ying Chen, Saeed Farooq, John Edwards, Carolyn A. Chew-Graham, David Shiers, Martin Frisher, Richard Hayward, Athula Sumathipala, Kelvin P. Jordan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The NASSS framework for ex post theorisation of technology-supported change in healthcare: worked example of the TORPEDO programme

Seye Abimbola, Bindu Patel, David Peiris, Anushka Patel, Mark Harris, Tim Usherwood, Trisha Greenhalgh

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