BMC Medicine

Exploring the causal role of intimate partner violence and abuse on depressive symptoms in young adults: a population-based cohort study

Annie Herbert, Jon Heron, Maria Barnes, Christine Barter, Gene Feder, Khadija Meghrawi, Eszter Szilassy, Abigail Fraser, Laura D. Howe

Predictors of cardio-kidney complications and treatment failure in patients with chronic kidney disease and type 2 diabetes treated with SGLT2 inhibitors

Csaba Kovesdy, Niklas Schmedt, Kerstin Folkerts, Kevin Bowrin, Hanaya Raad, Michael Batech, Linda Fried

Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis

Emmanouil Bouras, Ville Karhunen, Dipender Gill, Jian Huang, Philip C. Haycock, Marc J. Gunter, Mattias Johansson, Paul Brennan, Tim Key, Sarah J. Lewis, Richard M. Martin, Neil Murphy, Elizabeth A. Platz, Ruth Travis, James Yarmolinsky, Verena Zuber, Paul Martin, Michail Katsoulis, Heinz Freisling, Therese Haugdahl Nøst, Matthias B. Schulze, Laure Dossus, Rayjean J. Hung, Christopher I. Amos, Ari Ahola-Olli, Saranya Palaniswamy, Minna Männikkö, Juha Auvinen, Karl-Heinz Herzig, Sirkka Keinänen-Kiukaanniemi, Terho Lehtimäki, Veikko Salomaa, Olli Raitakari, Marko Salmi, Sirpa Jalkanen, CRUK, CAPS, PEGASUS, Marjo-Riitta Jarvelin, Abbas Dehghan, Konstantinos K. Tsilidis

Maternal cigarette smoking before or during pregnancy increases the risk of birth congenital anomalies: a population-based retrospective cohort study of 12 million mother-infant pairs

Lili Yang, Huan Wang, Liu Yang, Min Zhao, Yajun Guo, Pascal Bovet, Bo Xi

Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank

Hassan S. Dashti, Nicole Miranda, Brian E. Cade, Tianyi Huang, Susan Redline, Elizabeth W. Karlson, Richa Saxena

Variety and quantity of dietary protein intake from different sources and risk of new-onset diabetes: a Nationwide Cohort Study in China

Chun Zhou, Chengzhang Liu, Zhuxian Zhang, Mengyi Liu, Yuanyuan Zhang, Huan Li, Panpan He, Qinqin Li, Xianhui Qin

Ultra-processed food and incident type 2 diabetes: studying the underlying consumption patterns to unravel the health effects of this heterogeneous food category in the prospective Lifelines cohort

Ming-Jie Duan, Petra C. Vinke, Gerjan Navis, Eva Corpeleijn, Louise H. Dekker

Cell-free DNA methylation markers for differential diagnosis of hepatocellular carcinoma

Biyuan Luo, Fang Ma, Hao Liu, Jixiong Hu, Le Rao, Chun Liu, Yongfang Jiang, Shuyu Kuangzeng, Xuan Lin, Chenyang Wang, Yiyu Lei, Zhongzhou Si, Guangshun Chen, Ning Zhou, Chengbai Liang, Fangqing Jiang, Fenge Liu, Weidong Dai, Wei Liu, Yawen Gao, Zhihong Li, Xi Li, Guangyu Zhou, Bingsi Li, Zhihong Zhang, Weiqi Nian, Lihua Luo, Xianling Liu

Rapid intrapartum test for maternal group B streptococcal colonisation and its effect on antibiotic use in labouring women with risk factors for early-onset neonatal infection (GBS2): cluster randomised trial with nested test accuracy study

Jane P. Daniels, Emily Dixon, Alicia Gill, Jon Bishop, Mark Wilks, Michael Millar, Jim Gray, Tracy E. Roberts, Jane Plumb, Jonathan J. Deeks, Karla Hemming, Khalid S. Khan, Shakila Thangaratinam, Khaled Ahmed, Julie Dodds, Maria D’Amico, Kostas Tryposkiadis, Angela Whiley, Patrick Moore, Ruvimbo Lorraine Munetsi, Pallavi Karkhanis, Anne Deans, Sanjula Sharma, Gemma Wright, Manjula Subramanian, Irene Ray, Dibyenda Datta, Lauren Lacey, Johnathon Pepper, Ruth Mason, Neil Shah, Katharina Anwar, Neena Navaneetham, Shad Husain, Phillip Bennett, Geraldine Masson, Hristina Raykova, Matthew Hogg, Bashir Dawalatly, Lakshmi Thirumalaikumar, Kate Townsend, Gerry Collins, Paul Heath, Kerry Hood, Stavros Petrou, Ben Stenson, Sarah McMullen, Julia Saunders, Alison Stanley, Stephen Walters, Patrick Bossuyt, Ruth Gilbert, Rhona Hughes

Nudging customers towards healthier food and beverage purchases in a real-life online supermarket: a multi-arm randomized controlled trial

Josine M. Stuber, Jeroen Lakerveld, Loes W. Kievitsbosch, Joreintje D. Mackenbach, Joline W. J. Beulens

Short structural variants as informative genetic markers for ALS disease risk and progression

Frances Theunissen, Loren L. Flynn, Ryan S. Anderton, P. Anthony Akkari

Intracranial efficacy of alectinib in ALK-positive NSCLC patients with CNS metastases—a multicenter retrospective study

Zihua Zou, Puyuan Xing, Xuezhi Hao, Yan Wang, Xia Song, Li Shan, Cuiying Zhang, Ziling Liu, Kewei Ma, Guilan Dong, Junling Li

PCSK9 inhibitor recaticimab for hypercholesterolemia on stable statin dose: a randomized, double-blind, placebo-controlled phase 1b/2 study

Mingtong Xu, Xiaoxue Zhu, Junyan Wu, Yuling Zhang, Dong Zhao, Xuhong Wang, Yanhua Ding, Yu Cao, Chengqian Li, Wei Hu, Jianlong Sheng, Zhu Luo, Zeqi Zheng, Jinfang Hu, Jianying Liu, Xiaoyang Zhou, Aizong Shen, Xiaomei Ding, Yongdong Zhang, Yonggang Zhao, Yijing Li, Sheng Zhong, Shimin An, Jianjun Zou, Li Yan

The anti-aging factor Klotho protects against acquired long QT syndrome induced by uremia and promoted by fibroblast growth factor 23

José Alberto Navarro-García, Rafael Salguero-Bodes, Laura González-Lafuente, Laura Martín-Nunes, Elena Rodríguez-Sánchez, Teresa Bada-Bosch, Eduardo Hernández, Evangelina Mérida-Herrero, Manuel Praga, Jorge Solís, Fernando Arribas, Héctor Bueno, Makoto Kuro-O, María Fernández-Velasco, Luis Miguel Ruilope, Carmen Delgado, Gema Ruiz-Hurtado

The impact of sex and physical performance on long-term mortality in older patients with myocardial infarction

Elisabetta Tonet, Albert Ariza-Solé, Matteo Serenelli, Francesc Formiga, Juan Sanchis, Rita Pavasini, Pablo Diez-Villanueva, Francesco Vitali, Clara Bonanad, Giovanni Grazzi, Antoni Carol, Giorgio Chiaranda, Graziella Pompei, Laura Sofia Cardelli, Serena Caglioni, Federico Gibiino, Stefano Volpato, Gianluca Campo

Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy

Justyna Mączyńska, Florian Raes, Chiara Da Pieve, Stephen Turnock, Jessica K. R. Boult, Julia Hoebart, Marcin Niedbala, Simon P. Robinson, Kevin J. Harrington, Wojciech Kaspera, Gabriela Kramer-Marek

The empirical support for the radical cure strategy for eliminating Plasmodium vivax in China

Guo-Jing Yang, Le-Yuan Shang, Xiao-Nong Zhou, Tamsin E. Lee, Bo Bi, Michael White, Thomas A. Smith, Melissa A. Penny

Modest alcohol intake and mortality in individuals with elevated alanine aminotransferase levels: a nationwide cohort study

Dong Hyun Sinn, Danbee Kang, Eliseo Guallar, Yun Soo Hong, Juhee Cho, Geum-Youn Gwak

Association between hypertensive disorders of pregnancy and later risk of cardiovascular outcomes

Clare Oliver-Williams, David Stevens, Rupert A. Payne, Ian B. Wilkinson, Gordon C. S. Smith, Angela Wood

Variability in newborn telomere length is explained by inheritance and intrauterine environment

Li Chen, Karen Mei Ling Tan, Min Gong, Mary F. F. Chong, Kok Hian Tan, Yap Seng Chong, Michael J. Meaney, Peter D. Gluckman, Johan G. Eriksson, Neerja Karnani

Identification of heart failure with preserved ejection fraction helps risk stratification for hypertrophic cardiomyopathy

Jie Liu, Dong Wang, Jieyun Ruan, Guixin Wu, Lianjun Xu, Wen Jiang, Jizheng Wang, Xiaolu Sun, Lianming Kang, Lei Song

The effect of oral diabetes medications on glycated haemoglobin (HbA1c) in Asians in primary care: a retrospective cohort real-world data study

Hao Sen Andrew Fang, Qiao Gao, Wei Ying Tan, Mong Li Lee, Wynne Hsu, Ngiap Chuan Tan

Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) statement: updated reporting guidance for health economic evaluations

Don Husereau, Michael Drummond, Federico Augustovski, Esther de Bekker-Grob, Andrew H. Briggs, Chris Carswell, Lisa Caulley, Nathorn Chaiyakunapruk, Dan Greenberg, Elizabeth Loder, Josephine Mauskopf, C. Daniel Mullins, Stavros Petrou, Raoh-Fang Pwu, Sophie Staniszewska

Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients

Zhonghan Sun, Zhi-Gang Song, Chenglin Liu, Shishang Tan, Shuchun Lin, Jiajun Zhu, Fa-Hui Dai, Jian Gao, Jia-Lei She, Zhendong Mei, Tao Lou, Jiao-Jiao Zheng, Yi Liu, Jiang He, Yuanting Zheng, Chen Ding, Feng Qian, Yan Zheng, Yan-Mei Chen

Modelling upper respiratory viral load dynamics of SARS-CoV-2

Joseph D. Challenger, Cher Y. Foo, Yue Wu, Ada W. C. Yan, Mahdi Moradi Marjaneh, Felicity Liew, Ryan S. Thwaites, Lucy C. Okell, Aubrey J. Cunnington

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection

Feargal J. Ryan, Christopher M. Hope, Makutiro G. Masavuli, Miriam A. Lynn, Zelalem A. Mekonnen, Arthur Eng Lip Yeow, Pablo Garcia-Valtanen, Zahraa Al-Delfi, Jason Gummow, Catherine Ferguson, Stephanie O’Connor, Benjamin A. J. Reddi, Pravin Hissaria, David Shaw, Chuan Kok-Lim, Jonathan M. Gleadle, Michael R. Beard, Simon C. Barry, Branka Grubor-Bauk, David J. Lynn

Impact of a school-based health intervention program on body composition among South African primary schoolchildren: results from the KaziAfya cluster-randomized controlled trial

Kurt Z. Long, Johanna Beckmann, Christin Lang, Harald Seelig, Siphesihle Nqweniso, Nicole Probst-Hensch, Ivan Müller, Uwe Pühse, Peter Steinmann, Rosa du Randt, Cheryl Walter, Jürg Utzinger, Markus Gerber

Malaria hospitalisation in East Africa: age, phenotype and transmission intensity

Alice Kamau, Robert S. Paton, Samuel Akech, Arthur Mpimbaza, Cynthia Khazenzi, Morris Ogero, Eda Mumo, Victor A. Alegana, Ambrose Agweyu, Neema Mturi, Shebe Mohammed, Godfrey Bigogo, Allan Audi, James Kapisi, Asadu Sserwanga, Jane F. Namuganga, Simon Kariuki, Nancy A. Otieno, Bryan O. Nyawanda, Ally Olotu, Nahya Salim, Thabit Athuman, Salim Abdulla, Amina F. Mohamed, George Mtove, Hugh Reyburn, Sunetra Gupta, José Lourenço, Philip Bejon, Robert W. Snow

Single-dose SARS-CoV-2 vaccinations with either BNT162b2 or AZD1222 induce disparate Th1 responses and IgA production

Michael Müller, Johann Volzke, Behnam Subin, Silke Müller, Martina Sombetzki, Emil C. Reisinger, Brigitte Müller-Hilke

Implementation of the Mental Capacity Act: a national observational study comparing resultant trends in place of death for older heart failure decedents with or without comorbid dementia

James M. Beattie, Irene J. Higginson, Theresa A. McDonagh, Wei Gao

Humoral immune response after different SARS-CoV-2 vaccination regimens

Ruben Rose, Franziska Neumann, Olaf Grobe, Thomas Lorentz, Helmut Fickenscher, Andi Krumbholz

Dichotomy between the humoral and cellular responses elicited by mRNA and adenoviral vector vaccines against SARS-CoV-2

Rahul Ukey, Natalie Bruiners, Hridesh Mishra, Pankaj K. Mishra, Deborah McCloskey, Alberta Onyuka, Fei Chen, Abraham Pinter, Daniela Weiskopf, Alessandro Sette, Jason Roy, Sunanda Gaur, Maria Laura Gennaro

Epidemiology and control of SARS-CoV-2 epidemics in partially vaccinated populations: a modeling study applied to France

Paolo Bosetti, Cécile Tran Kiem, Alessio Andronico, Vittoria Colizza, Yazdan Yazdanpanah, Arnaud Fontanet, Daniel Benamouzig, Simon Cauchemez

Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomisation using polygenic risk scores

Tom A. Bond, Rebecca C. Richmond, Ville Karhunen, Gabriel Cuellar-Partida, Maria Carolina Borges, Verena Zuber, Alexessander Couto Alves, Dan Mason, Tiffany C. Yang, Marc J. Gunter, Abbas Dehghan, Ioanna Tzoulaki, Sylvain Sebert, David M. Evans, Alex M. Lewin, Paul F. O’Reilly, Deborah A. Lawlor, Marjo-Riitta Järvelin

Human placental mesenchymal stromal cells are ciliated and their ciliation is compromised in preeclampsia

Sophia Indira Romberg, Nina-Naomi Kreis, Alexandra Friemel, Susanne Roth, Alice Steglich Souto, Samira Catharina Hoock, Kyra Fischer, Thorsten Nowak, Christine Solbach, Frank Louwen, Andreas Ritter, Juping Yuan

Prediction of long-term kinetics of vaccine-elicited neutralizing antibody and time-varying vaccine-specific efficacy against the SARS-CoV-2 Delta variant by clinical endpoint

Xinhua Chen, Wei Wang, Xinghui Chen, Qianhui Wu, Ruijia Sun, Shijia Ge, Nan Zheng, Wanying Lu, Juan Yang, Lance Rodewald, Hongjie Yu

Investigating vaccine-induced immunity and its effect in mitigating SARS-CoV-2 epidemics in China

Hengcong Liu, Juanjuan Zhang, Jun Cai, Xiaowei Deng, Cheng Peng, Xinghui Chen, Juan Yang, Qianhui Wu, Xinhua Chen, Zhiyuan Chen, Wen Zheng, Cécile Viboud, Wenhong Zhang, Marco Ajelli, Hongjie Yu

Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation

Karen Grewal, Yun S. Lee, Ann Smith, Jan J. Brosens, Tom Bourne, Maya Al-Memar, Samit Kundu, David A. MacIntyre, Phillip R. Bennett

The role of diet in renal cell carcinoma incidence: an umbrella review of meta-analyses of observational studies

Zhanchen Liao, Zhitao Fang, Siqi Gou, Yong Luo, Yiqi Liu, Zhun He, Xin Li, Yansong Peng, Zheng Fu, Dongjin Li, Haiyun Chen, Zhigang Luo

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization

Mark Gormley, Tom Dudding, Linda Kachuri, Kimberley Burrows, Amanda H. W. Chong, Richard M. Martin, Steven J. Thomas, Jessica Tyrrell, Andrew R. Ness, Paul Brennan, Marcus R. Munafò, Miranda Pring, Stefania Boccia, Andrew F. Olshan, Brenda Diergaarde, Rayjean J. Hung, Geoffrey Liu, Eloiza H. Tajara, Patricia Severino, Tatiana N. Toporcov, Martin Lacko, Tim Waterboer, Nicole Brenner, George Davey Smith, Emma E. Vincent, Rebecca C. Richmond

Systematic review of Mendelian randomization studies on risk of cancer

Georgios Markozannes, Afroditi Kanellopoulou, Olympia Dimopoulou, Dimitrios Kosmidis, Xiaomeng Zhang, Lijuan Wang, Evropi Theodoratou, Dipender Gill, Stephen Burgess, Konstantinos K. Tsilidis

Efficacy and safety of pyrotinib in advanced lung adenocarcinoma with HER2 mutations: a multicenter, single-arm, phase II trial

Zhengbo Song, Yuping Li, Shiqing Chen, Shenpeng Ying, Shuguang Xu, Jianjin Huang, Dan Wu, Dongqing Lv, Ting Bei, Shuxun Liu, Xiaoping Huang, Congying Xie, Xiaoyu Wu, Jianfei Fu, Feng Hua, Wenxian Wang, Chunwei Xu, Chan Gao, Shangli Cai, Shun Lu, Yiping Zhang

The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records

Rebecca M. Joseph, Ruth H. Jack, Richard Morriss, Roger David Knaggs, Debbie Butler, Chris Hollis, Julia Hippisley-Cox, Carol Coupland

Nonlinear causal effects of estimated glomerular filtration rate on myocardial infarction risks: Mendelian randomization study

Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Hyeok Huh, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim

Personalised treatment for cognitive impairment in dementia: development and validation of an artificial intelligence model

Qiang Liu, Nemanja Vaci, Ivan Koychev, Andrey Kormilitzin, Zhenpeng Li, Andrea Cipriani, Alejo Nevado-Holgado

Trend and projection of skilled birth attendants and institutional delivery coverage for adolescents in 54 low- and middle-income countries, 2000–2030

Md. Mizanur Rahman, Hiroko Taniguchi, Raïssa Shiyghan Nsashiyi, Rashedul Islam, Syed Riaz Mahmud, Shafiur Rahman, Jenny Jung, Shahjahan Khan

Is metabolic syndrome a risk factor in hepatectomy? A meta-analysis with subgroup analysis for histologically confirmed hepatic manifestations

Anastasia Murtha-Lemekhova, Juri Fuchs, Svenja Feiler, Erik Schulz, Miriam Teroerde, Eva Kalkum, Rosa Klotz, Adrian Billeter, Pascal Probst, Katrin Hoffmann

Circulating tumor cell gene expression and plasma AR gene copy number as biomarkers for castration-resistant prostate cancer patients treated with cabazitaxel

Giorgia Gurioli, Vincenza Conteduca, Nicole Brighi, Emanuela Scarpi, Umberto Basso, Giuseppe Fornarini, Alessandra Mosca, Maurizio Nicodemo, Giuseppe Luigi Banna, Cristian Lolli, Giuseppe Schepisi, Giorgia Ravaglia, Isabella Bondi, Paola Ulivi, Ugo De Giorgi

Effect of an osteoporotic fracture prevention program on fracture incidence in routine care: a cluster-randomized trial

Kilian Rapp, Sarah E. Lamb, Patrick Roigk, Clemens Becker, Claudia Konnopka, Hans-Helmut König, Raphael S. Peter, Dietrich Rothenbacher, Gisela Büchele

Studying the post-COVID-19 condition: research challenges, strategies, and importance of Core Outcome Set development

Daniel Munblit, Timothy R. Nicholson, Dale M. Needham, Nina Seylanova, Callum Parr, Jessica Chen, Alisa Kokorina, Louise Sigfrid, Danilo Buonsenso, Shinjini Bhatnagar, Ramachandran Thiruvengadam, Ann M. Parker, Jacobus Preller, Sergey Avdeev, Frederikus A. Klok, Allison Tong, Janet V. Diaz, Wouter De Groote, Nicoline Schiess, Athena Akrami, Frances Simpson, Piero Olliaro, Christian Apfelbacher, Regis Goulart Rosa, Jennifer R. Chevinsky, Sharon Saydah, Jochen Schmitt, Alla Guekht, Sarah L. Gorst, Jon Genuneit, Luis Felipe Reyes, Alan Asmanov, Margaret E. O’Hara, Janet T. Scott, Melina Michelen, Charitini Stavropoulou, John O. Warner, Margaret Herridge, Paula R. Williamson

Estimating the effect of non-pharmaceutical interventions to mitigate COVID-19 spread in Saudi Arabia

Donal Bisanzio, Richard Reithinger, Ada Alqunaibet, Sami Almudarra, Reem F. Alsukait, Di Dong, Yi Zhang, Sameh El-Saharty, Christopher H. Herbst

Protective action of natural and induced immunization against the occurrence of delta or alpha variants of SARS-CoV-2 infection: a test-negative case-control study

Giovanni Corrao, Matteo Franchi, Federico Rea, Danilo Cereda, Antonio Barone, Catia Rosanna Borriello, Petra Giulia Della Valle, Michele Ercolanoni, Ida Fortino, Jose Jara, Olivia Leoni, Francesco Mazziotta, Elisabetta Pierini, Giuseppe Preziosi, Marcello Tirani, Massimo Galli, Guido Bertolaso, Giovanni Pavesi, Francesco Bortolan

Multimorbidity and co-occurring musculoskeletal pain do not modify the effect of the selfBACK app on low back pain-related disability

Cecilie K. Øverås, Tom I. L. Nilsen, Barbara I. Nicholl, Guy Rughani, Karen Wood, Karen Søgaard, Frances S. Mair, Jan Hartvigsen

Systematic review and meta-analysis of the diagnostic accuracy of prostate-specific antigen (PSA) for the detection of prostate cancer in symptomatic patients

Samuel W. D. Merriel, Lucy Pocock, Emma Gilbert, Sam Creavin, Fiona M. Walter, Anne Spencer, Willie Hamilton

Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancer

Yuanyuan Zhang, Ning Li, Guangwen Yuan, Hongwen Yao, Die Zhang, Nan Li, Gongyi Zhang, Yangchun Sun, Wenpeng Wang, Jia Zeng, Ningzhi Xu, Mei Liu, Lingying Wu

Effects of personalized diets by prediction of glycemic responses on glycemic control and metabolic health in newly diagnosed T2DM: a randomized dietary intervention pilot trial

Michal Rein, Orly Ben-Yacov, Anastasia Godneva, Smadar Shilo, Niv Zmora, Dmitry Kolobkov, Noa Cohen-Dolev, Bat-Chen Wolf, Noa Kosower, Maya Lotan-Pompan, Adina Weinberger, Zamir Halpern, Shira Zelber-Sagi, Eran Elinav, Eran Segal

Observed and predicted premature mortality in Australia due to non-communicable diseases: a population-based study examining progress towards the WHO 25X25 goal

Alison Wijnen, Karen Bishop, Grace Joshy, Yuehan Zhang, Emily Banks, Ellie Paige

Regional-based within-year seasonal variations in influenza-related health outcomes across mainland China: a systematic review and spatio-temporal analysis

Charlie Diamond, Hui Gong, Fiona Yueqian Sun, Yang Liu, Billy J. Quilty, Mark Jit, Juan Yang, Hongjie Yu, W. John Edmunds, Marc Baguelin

c-MET/VEGFR-2 co-localisation impacts on survival following bevacizumab therapy in epithelial ovarian cancer: an exploratory biomarker study of the phase 3 ICON7 trial

Robert D. Morgan, Cristina Ferreras, Isabel Peset, Egle Avizienyte, Andrew G. Renehan, Richard J. Edmondson, Alexander D. Murphy, Shibani Nicum, Thomas Van Brussel, Andrew R. Clamp, Diether Lambrechts, Cong Zhou, Gordon C. Jayson

Association between adverse childhood experiences and premenstrual disorders: a cross-sectional analysis of 11,973 women

Qian Yang, Edda Björk Þórðardóttir, Arna Hauksdóttir, Thor Aspelund, Jóhanna Jakobsdóttir, Thorhildur Halldorsdottir, Gunnar Tomasson, Harpa Rúnarsdóttir, Hilda Björk Danielsdottir, Elizabeth R. Bertone-Johnson, Arvid Sjölander, Fang Fang, Donghao Lu, Unnur Anna Valdimarsdóttir

Associations between cervical intraepithelial neoplasia during pregnancy, previous excisional treatment, cone-length and preterm delivery: a register-based study from western Sweden

Johanna Wiik, Cecilia Kärrberg, Staffan Nilsson, Björn Strander, Bo Jacobsson, Verena Sengpiel

High polygenic predisposition for ADHD and a greater risk of all-cause mortality: a large population-based longitudinal study

Olesya Ajnakina, Diana Shamsutdinova, Theresa Wimberley, Søren Dalsgaard, Andrew Steptoe

Lifetime risk of cardiovascular-renal disease in type 2 diabetes: a population-based study in 473,399 individuals

Ruiqi Zhang, Jil Billy Mamza, Tamsin Morris, George Godfrey, Folkert W. Asselbergs, Spiros Denaxas, Harry Hemingway, Amitava Banerjee

Common DNA methylation changes in biliary tract cancers identify subtypes with different immune characteristics and clinical outcomes

Zhiquan Qiu, Jun Ji, Yu Xu, Yan Zhu, Chunfang Gao, Guoqiang Wang, Chengcheng Li, Yuzi Zhang, Jing Zhao, Chenyang Wang, Xiaofang Wen, Zhou Zhang, Bingsi Li, Zhihong Zhang, Shangli Cai, Bin Li, Xiaoqing Jiang

Obesity, metabolic risk and adherence to healthy lifestyle behaviours: prospective cohort study in the UK Biobank

Laura Heath, Susan A. Jebb, Paul Aveyard, Carmen Piernas

Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis

Qianwen Liu, Zhaozhong Zhu, Peter Kraft, Qiaolin Deng, Elisabet Stener-Victorin, Xia Jiang

Enhanced intestinal protein fermentation in schizophrenia

Ying Liang, Xing Shi, Yang Shen, Zhuoran Huang, Jian Wang, Changjun Shao, Yanan Chu, Jing Chen, Jun Yu, Yu Kang

Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants

Rui Chen, Jiewei Liu, Shiwu Li, Xiaoyan Li, Yongxia Huo, Yong-Gang Yao, Xiao Xiao, Ming Li, Xiong-Jian Luo

The impact of kidney function in patients on antithrombotic therapy: a post hoc subgroup analysis focusing on recurrent bleeding events from the AFIRE trial

Kunihiko Matsui, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Hisao Ogawa

Risk/benefit tradeoff of habitual physical activity and air pollution on chronic pulmonary obstructive disease: findings from a large prospective cohort study

Lan Chen, Miao Cai, Haitao Li, Xiaojie Wang, Fei Tian, Yinglin Wu, Zilong Zhang, Hualiang Lin

Global prevalence and burden of meal-related abdominal pain

Esther Colomier, Chloé Melchior, Joost P. Algera, Jóhann P. Hreinsson, Stine Störsrud, Hans Törnblom, Lukas Van Oudenhove, Olafur S. Palsson, Shrikant I. Bangdiwala, Ami D. Sperber, Jan Tack, Magnus Simrén

The impact of race and ethnicity in breast cancer—disparities and implications for precision oncology

Kelly A. Hirko, Gabrielle Rocque, Erica Reasor, Ammanuel Taye, Alex Daly, Ramsey I. Cutress, Ellen R. Copson, Dae-Won Lee, Kyung-Hun Lee, Seock-Ah Im, Yeon Hee Park

Risk of cancer in regular and low meat-eaters, fish-eaters, and vegetarians: a prospective analysis of UK Biobank participants

Cody Z. Watling, Julie A. Schmidt, Yashvee Dunneram, Tammy Y. N. Tong, Rebecca K. Kelly, Anika Knuppel, Ruth C. Travis, Timothy J. Key, Aurora Perez-Cornago

Deep learning radiomics based on contrast-enhanced ultrasound images for assisted diagnosis of pancreatic ductal adenocarcinoma and chronic pancreatitis

Tong Tong, Jionghui Gu, Dong Xu, Ling Song, Qiyu Zhao, Fang Cheng, Zhiqiang Yuan, Shuyuan Tian, Xin Yang, Jie Tian, Kun Wang, Tian’an Jiang

Promoting deceased organ and tissue donation registration in family physician waiting rooms (RegisterNow-1): a pragmatic stepped-wedge, cluster randomized controlled registry trial

Alvin Ho-ting Li, Amit X. Garg, Jeremy M. Grimshaw, Versha Prakash, Alexie J. Dunnett, Stephanie N. Dixon, Monica Taljaard, Joanna Mitchell, Kyla L. Naylor, Cathy Faulds, Rachel Bevan, Leah Getchell, Greg Knoll, S. Joseph Kim, Jessica Sontrop, Allison Tong, Lise M. Bjerre, Karyn Hyjek, Donna Currie, Susan Edwards, Mike Sullivan, Linda Harvey-Rioux, Justin Presseau

GWAS in people of Middle Eastern descent reveals a locus protective of kidney function—a cross-sectional study

Siham A. Mohamed, Juan Fernadez-Tajes, Paul W. Franks, Louise Bennet

The impact of local vaccine coverage and recent incidence on measles transmission in France between 2009 and 2018

Alexis Robert, Adam J. Kucharski, Sebastian Funk

Predictive validity of the Stopping Elderly Accidents, Deaths & Injuries (STEADI) program fall risk screening algorithms among community-dwelling Thai elderly

Sriprapa Loonlawong, Weerawat Limroongreungrat, Thanapoom Rattananupong, Kamonrat Kittipimpanon, Wanvisa Saisanan Na Ayudhaya, Wiroj Jiamjarasrangsi

Association of meat, vegetarian, pescatarian and fish-poultry diets with risk of 19 cancer sites and all cancer: findings from the UK Biobank prospective cohort study and meta-analysis

Solange Parra-Soto, Danay Ahumada, Fanny Petermann-Rocha, Jirapitcha Boonpoor, Jose Lara Gallegos, Jana Anderson, Linda Sharp, Fiona C. Malcomson, Katherine M. Livingstone, John C. Mathers, Jill P. Pell, Frederick K. Ho, Carlos Celis-Morales

Mitigating the SARS-CoV-2 Delta disease burden in Australia by non-pharmaceutical interventions and vaccinating children: a modelling analysis

George J. Milne, Julian Carrivick, David Whyatt

Vegetarian diets and cancer risk

Mathias Weller

Asthma and the risk of gastrointestinal disorders: a Mendelian randomization study

Dennis Freuer, Jakob Linseisen, Christa Meisinger

A single-oral bolus of 100,000 IU of cholecalciferol at hospital admission did not improve outcomes in the COVID-19 disease: the COVID-VIT-D—a randomised multicentre international clinical trial

Jorge B. Cannata-Andía, Augusto Díaz-Sottolano, Pehuén Fernández, Carmen Palomo-Antequera, Pablo Herrero-Puente, Ricardo Mouzo, Natalia Carrillo-López, Sara Panizo, Guillermo H. Ibañez, Carlos A. Cusumano, Carolina Ballarino, Vicente Sánchez-Polo, Jacqueline Pefaur-Penna, Irene Maderuelo-Riesco, Jesús Calviño-Varela, Mónica D. Gómez, Carlos Gómez-Alonso, John Cunningham, Manuel Naves-Díaz, Walter Douthat, José L. Fernández-Martín

Activity and safety of SHR3680, a novel antiandrogen, in patients with metastatic castration-resistant prostate cancer: a phase I/II trial

Xiaojian Qin, Dongmei Ji, Weijie Gu, Weiqing Han, Hong Luo, Chuanjun Du, Qing Zou, Zhongquan Sun, Chaohong He, Shaoxing Zhu, Tie Chong, Xin Yao, Ben Wan, Xinfeng Yang, Aobing Bai, Chunlei Jin, Jianjun Zou, Dingwei Ye

Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

Rashid Mansoor, Robert J. Commons, Nicholas M. Douglas, Benjamin Abuaku, Jane Achan, Ishag Adam, George O. Adjei, Martin Adjuik, Bereket H. Alemayehu, Richard Allan, Elizabeth N. Allen, Anupkumar R. Anvikar, Emmanuel Arinaitwe, Elizabeth A. Ashley, Hazel Ashurst, Puji B. S. Asih, Nathan Bakyaita, Hubert Barennes, Karen I. Barnes, Leonardo Basco, Quique Bassat, Elisabeth Baudin, David J Bell, Delia Bethell, Anders Bjorkman, Caroline Boulton, Teun Bousema, Philippe Brasseur, Hasifa Bukirwa, Rebekah Burrow, Verena I. Carrara, Michel Cot, Umberto D’Alessandro, Debashish Das, Sabyasachi Das, Timothy M. E. Davis, Meghna Desai, Abdoulaye A. Djimde, Arjen M. Dondorp, Grant Dorsey, Chris J. Drakeley, Stephan Duparc, Emmanuelle Espié, Jean-Francois Etard, Catherine Falade, Jean Francois Faucher, Scott Filler, Carole Fogg, Mark Fukuda, Oumar Gaye, Blaise Genton, Awab Ghulam Rahim, Julius Gilayeneh, Raquel Gonzalez, Rebecca F. Grais, Francesco Grandesso, Brian Greenwood, Anastasia Grivoyannis, Christoph Hatz, Eva Maria Hodel, Georgina S. Humphreys, Jimee Hwang, Deus Ishengoma, Elizabeth Juma, S. Patrick Kachur, Piet A. Kager, Erasmus Kamugisha, Moses R. Kamya, Corine Karema, Kassoum Kayentao, Adama Kazienga, Jean-René Kiechel, Poul-Erik Kofoed, Kwadwo Koram, Peter G. Kremsner, David G. Lalloo, Moses Laman, Sue J. Lee, Bertrand Lell, Amelia W. Maiga, Andreas Mårtensson, Mayfong Mayxay, Wilfred Mbacham, Rose McGready, Hervé Menan, Didier Ménard, Frank Mockenhaupt, Brioni R. Moore, Olaf Müller, Alain Nahum, Jean-Louis Ndiaye, Paul N. Newton, Billy E. Ngasala, Frederic Nikiema, Akindeh M. Nji, Harald Noedl, Francois Nosten, Bernhards R. Ogutu, Olusola Ojurongbe, Lyda Osorio, Jean-Bosco Ouédraogo, Seth Owusu-Agyei, Anil Pareek, Louis K. Penali, Patrice Piola, Mateusz Plucinski, Zul Premji, Michael Ramharter, Caitlin L. Richmond, Lars Rombo, Cally Roper, Philip J. Rosenthal, Sam Salman, Albert Same-Ekobo, Carol Sibley, Sodiomon B. Sirima, Frank M. Smithuis, Fabrice A. Somé, Sarah G. Staedke, Peter Starzengruber, Nathalie Strub-Wourgaft, Inge Sutanto, Todd D. Swarthout, Din Syafruddin, Ambrose O. Talisuna, Walter R. Taylor, Emmanuel A. Temu, Julie I. Thwing, Halidou Tinto, Emiliana Tjitra, Offianan A. Touré, T. Hien Tran, Johan Ursing, Innocent Valea, Giovanni Valentini, Michele van Vugt, Lorenz von Seidlein, Stephen A. Ward, Vincent Were, Nicholas J. White, Charles J. Woodrow, William Yavo, Adoke Yeka, Issaka Zongo, Julie A. Simpson, Philippe J. Guerin, Kasia Stepniewska, Ric N. Price

Comparative assessment of methods for short-term forecasts of COVID-19 hospital admissions in England at the local level

Sophie Meakin, Sam Abbott, Nikos Bosse, James Munday, Hugo Gruson, Joel Hellewell, Katharine Sherratt, Lloyd A. C. Chapman, Kiesha Prem, Petra Klepac, Thibaut Jombart, Gwenan M. Knight, Yalda Jafari, Stefan Flasche, William Waites, Mark Jit, Rosalind M. Eggo, C. Julian Villabona-Arenas, Timothy W. Russell, Graham Medley, W. John Edmunds, Nicholas G. Davies, Yang Liu, Stéphane Hué, Oliver Brady, Rachael Pung, Kaja Abbas, Amy Gimma, Paul Mee, Akira Endo, Samuel Clifford, Fiona Yueqian Sun, Ciara V. McCarthy, Billy J. Quilty, Alicia Rosello, Frank G. Sandmann, Rosanna C. Barnard, Adam J. Kucharski, Simon R. Procter, Christopher I. Jarvis, Hamish P. Gibbs, David Hodgson, Rachel Lowe, Katherine E. Atkins, Mihaly Koltai, Carl A. B. Pearson, Emilie Finch, Kerry L. M. Wong, Matthew Quaife, Kathleen O’Reilly, Damien C. Tully, Sebastian Funk

Determinants of pre-vaccination antibody responses to SARS-CoV-2: a population-based longitudinal study (COVIDENCE UK)

Mohammad Talaei, Sian Faustini, Hayley Holt, David A. Jolliffe, Giulia Vivaldi, Matthew Greenig, Natalia Perdek, Sheena Maltby, Carola M. Bigogno, Jane Symons, Gwyneth A. Davies, Ronan A. Lyons, Christopher J. Griffiths, Frank Kee, Aziz Sheikh, Alex G. Richter, Seif O. Shaheen, Adrian R. Martineau

WHO-led consensus statement on vaccine delivery costing: process, methods, and findings

Ann Levin, Laura Boonstoppel, Logan Brenzel, Ulla Griffiths, Raymond Hutubessy, Mark Jit, Vittal Mogasale, Sarah Pallas, Stephen Resch, Christian Suharlim, Karene Hoi Ting Yeung

Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand

Zoe Shih-Jung Liu, Jetsumon Sattabongkot, Michael White, Sadudee Chotirat, Chalermpon Kumpitak, Eizo Takashima, Matthias Harbers, Wai-Hong Tham, Julie Healer, Chetan E. Chitnis, Takafumi Tsuboi, Ivo Mueller, Rhea J. Longley

Targeted therapies for cancer

Zhijun Zhou, Min Li

Heart rate variability is associated with left ventricular systolic, diastolic function and incident heart failure in the general population

Banafsheh Arshi, Sven Geurts, Martijn J. Tilly, Marten van den Berg, Jan A. Kors, Dimitris Rizopoulos, M. Arfan Ikram, Maryam Kavousi

Long COVID 12 months after discharge: persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes—a multicentre cohort study

Mario Rivera-Izquierdo, Antonio Jesús Láinez-Ramos-Bossini, Inmaculada Guerrero-Fernández de Alba, Rocío Ortiz-González-Serna, Álvaro Serrano-Ortiz, Nicolás Francisco Fernández-Martínez, Rafael Ruiz-Montero, Jorge A. Cervilla

Ezetimibe combination therapy with statin for non-alcoholic fatty liver disease: an open-label randomized controlled trial (ESSENTIAL study)

Yongin Cho, Hyungjin Rhee, Young-eun Kim, Minyoung Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Jin-Young Choi, Yong-ho Lee

The influence of childhood asthma on adult height: evidence from the UK Biobank

Wenwen Chen, Huazhen Yang, Can Hou, Yajing Sun, Yanan Shang, Yu Zeng, Yao Hu, Yuanyuan Qu, Jianwei Zhu, Fang Fang, Donghao Lu, Huan Song

Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes

Jérémie Gautheron, Lara Lima, Baris Akinci, Jamila Zammouri, Martine Auclair, Sema Kalkan Ucar, Samim Ozen, Canan Altay, Bridget E. Bax, Ivan Nemazanyy, Véronique Lenoir, Carina Prip-Buus, Cécile Acquaviva-Bourdain, Olivier Lascols, Bruno Fève, Corinne Vigouroux, Esther Noel, Isabelle Jéru

The University of Padua salivary-based SARS-CoV-2 surveillance program minimized viral transmission during the second and third pandemic wave

Daniela Basso, Ada Aita, Filippo Navaglia, Paola Mason, Stefania Moz, Alessio Pinato, Barbara Melloni, Luca Iannelli, Andrea Padoan, Chiara Cosma, Angelo Moretto, Alberto Scuttari, Daniela Mapelli, Rosario Rizzuto, Mario Plebani

Detection of SARS-CoV-2 infection in the general population by three prevailing rapid antigen tests: cross-sectional diagnostic accuracy study

Roderick P. Venekamp, Irene K. Veldhuijzen, Karel G. M. Moons, Wouter van den Bijllaardt, Suzan D. Pas, Esther B. Lodder, Richard Molenkamp, Zsofi Igloi, Constantijn Wijers, Claudy Oliveira dos Santos, Sylvia B. Debast, Marjan J. Bruins, Khaled Polad, Carla R. S. Nagel-Imming, Wanda G. H. Han, Janneke H. H. M. van de Wijgert, Susan van den Hof, Ewoud Schuit

Developing sero-diagnostic tests to facilitate Plasmodium vivax Serological Test-and-Treat approaches: modeling the balance between public health impact and overtreatment

Thomas Obadia, Narimane Nekkab, Leanne J. Robinson, Chris Drakeley, Ivo Mueller, Michael T. White

Correction to: The epidemiologic impact and cost-effectiveness of new tuberculosis vaccines on multidrug-resistant tuberculosis in India and China

Chathika K. Weerasuriya, Rebecca C. Harris, C. Finn McQuaid, Fiammetta Bozzani, Yunzhou Ruan, Renzhong Li, Tao Li, Kirankumar Rade, Raghuram Rao, Ann M. Ginsberg, Gabriela B. Gomez, Richard G. White

Risk factors associated with short-term adverse events after SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases

Luuk Wieske, Laura Y. L. Kummer, Koos P. J. van Dam, Eileen W. Stalman, Anneke J. van der Kooi, Joost Raaphorst, Mark Löwenberg, R. Bart Takkenberg, Adriaan G. Volkers, Geert R. A. M. D’Haens, Sander W. Tas, Phyllis I. Spuls, Marcel W. Bekkenk, Annelie H. Musters, Nicoline F. Post, Angela L. Bosma, Marc L. Hilhorst, Yosta Vegting, Frederike J. Bemelman, Joep Killestein, Zoé L. E. van Kempen, Alexandre E. Voskuyl, Bo Broens, Agner Parra Sanchez, Gertjan Wolbink, Laura Boekel, Abraham Rutgers, Karina de Leeuw, Barbara Horváth, Jan J. G. M. Verschuuren, Annabel M. Ruiter, Lotte van Ouwerkerk, Diane van der Woude, Cornelia F. Allaart, Y. K. Onno Teng, Pieter van Paassen, Matthias H. Busch, B. Papay Jallah, Esther Brusse, Pieter A. van Doorn, Adája E. Baars, Dirkjan Hijnen, Corine R. G. Schreurs, W. Ludo van der Pol, H. Stephan Goedee, Maurice Steenhuis, Theo Rispens, Anja ten Brinke, Niels J. M. Verstegen, Koos A. H. Zwinderman, S. Marieke van Ham, Taco W. Kuijpers, Filip Eftimov

An international consensus on the essential and desirable criteria for an ‘organized’ cancer screening programme

Li Zhang, André L. Carvalho, Isabel Mosquera, Tianmeng Wen, Eric Lucas, Catherine Sauvaget, Richard Muwonge, Marc Arbyn, Elisabete Weiderpass, Partha Basu

Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant

Maren Schubert, Federico Bertoglio, Stephan Steinke, Philip Alexander Heine, Mario Alberto Ynga-Durand, Henrike Maass, Josè Camilla Sammartino, Irene Cassaniti, Fanglei Zuo, Likun Du, Janin Korn, Marko Milošević, Esther Veronika Wenzel, Fran Krstanović, Saskia Polten, Marina Pribanić-Matešić, Ilija Brizić, Fausto Baldanti, Lennart Hammarström, Stefan Dübel, Alan Šustić, Harold Marcotte, Monika Strengert, Alen Protić, Antonio Piralla, Qiang Pan-Hammarström, Luka Čičin-Šain, Michael Hust

The relationships between women’s reproductive factors: a Mendelian randomisation analysis

Claire Prince, Gemma C. Sharp, Laura D. Howe, Abigail Fraser, Rebecca C. Richmond

The association between assisted reproductive technology and cardiac remodeling in fetuses and early infants: a prospective cohort study

Wenjing Bi, Yangjie Xiao, Xin Wang, Li Cui, Guang Song, Zeyu Yang, Ying Zhang, Weidong Ren

HER2 expression, copy number variation and survival outcomes in HER2-low non-metastatic breast cancer: an international multicentre cohort study and TCGA-METABRIC analysis

Ryan Shea Ying Cong Tan, Whee Sze Ong, Kyung-Hun Lee, Abner Herbert Lim, Seri Park, Yeon Hee Park, Ching-Hung Lin, Yen-Shen Lu, Makiko Ono, Takayuki Ueno, Yoichi Naito, Tatsuya Onishi, Geok-Hoon Lim, Su-Ming Tan, Han-Byoel Lee, Han Suk Ryu, Wonshik Han, Veronique Kiak Mien Tan, Fuh-Yong Wong, Seock-Ah Im, Puay Hoon Tan, Jason Yongsheng Chan, Yoon-Sim Yap

The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design

Madeleine Michaëlsson, Shuai Yuan, Håkan Melhus, John A. Baron, Liisa Byberg, Susanna C. Larsson, Karl Michaëlsson

Neoadjuvant apatinib combined with oxaliplatin and capecitabine in patients with locally advanced adenocarcinoma of stomach or gastroesophageal junction: a single-arm, open-label, phase 2 trial

Zhaoqing Tang, Yan Wang, Yiyi Yu, Yuehong Cui, Liang Liang, Chen Xu, Zhenbin Shen, Kuntang Shen, Xuefei Wang, Tianshu Liu, Yihong Sun

Selinexor plus low-dose dexamethasone in Chinese patients with relapsed/refractory multiple myeloma previously treated with an immunomodulatory agent and a proteasome inhibitor (MARCH): a phase II, single-arm study

Lugui Qiu, Zhongjun Xia, Chengcheng Fu, Wenming Chen, Chunkang Chang, Baijun Fang, Gang An, Yongqiang Wei, Zhen Cai, Sujun Gao, Jianyu Weng, Lijuan Chen, Hongmei Jing, Fei Li, Zhuogang Liu, Xiequn Chen, Jing Liu, Aihua Wang, Yang Yu, Wenxi Xiang, Kevin Lynch, Zhinuan Yu, Weijun Fu

The compensatory reserve index predicts recurrent shock in patients with severe dengue

Huynh Trung Trieu, Lam Phung Khanh, Damien Keng Yen Ming, Chanh Ho Quang, Tu Qui Phan, Vinh Chau Nguyen Van, Ertan Deniz, Jane Mulligan, Bridget Ann Wills, Steven Moulton, Sophie Yacoub

Physical activity enhances the improvement of body mass index and metabolism by inulin: a multicenter randomized placebo-controlled trial performed in obese individuals

Julie Rodriguez, Audrey M. Neyrinck, Maxime Van Kerckhoven, Marco A. Gianfrancesco, Edith Renguet, Luc Bertrand, Patrice D. Cani, Nicolas Lanthier, Miriam Cnop, Nicolas Paquot, Jean-Paul Thissen, Laure B. Bindels, Nathalie M. Delzenne

Differences in risk factors for incident and recurrent preterm birth: a population-based linkage of 3.5 million births from the CIDACS birth cohort

Aline S. Rocha, Rita de Cássia Ribeiro-Silva, Rosemeire L. Fiaccone, Enny S. Paixao, Ila R. Falcão, Flavia Jôse O. Alves, Natanael J. Silva, Naiá Ortelan, Laura C. Rodrigues, Maria Yury Ichihara, Marcia F. de Almeida, Mauricio L. Barreto

Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer

Blossom Mak, Hui-Ming Lin, Edmond M. Kwan, Heidi Fettke, Ben Tran, Ian D. Davis, Kate Mahon, Martin R. Stockler, Karen Briscoe, Gavin Marx, Alison Zhang, Megan Crumbaker, Winston Tan, Kevin Huynh, Thomas G. Meikle, Natalie A. Mellett, Andrew J. Hoy, Pan Du, Jianjun Yu, Shidong Jia, Anthony M. Joshua, David J. Waugh, Lisa M. Butler, Manish Kohli, Peter J. Meikle, Arun A. Azad, Lisa G. Horvath

Differential health impact of intervention programs for time-varying disease risk: a measles vaccination modeling study

Allison Portnoy, Yuli Lily Hsieh, Kaja Abbas, Petra Klepac, Heather Santos, Logan Brenzel, Mark Jit, Matthew Ferrari

Maternal factors during pregnancy influencing maternal, fetal and childhood outcomes: Meet the Guest Editors

Louis Muglia, Stephen Tong, Susan Ozanne, Katrien Benhalima

Immune responses in the irritable bowel syndromes: time to consider the small intestine

Grace L. Burns, Nicholas J. Talley, Simon Keely

Combining faecal immunochemical testing with blood test results for colorectal cancer risk stratification: a consecutive cohort of 16,604 patients presenting to primary care

Diana R. Withrow, Brian Shine, Jason Oke, Andres Tamm, Tim James, Eva Morris, Jim Davies, Steve Harris, James E. East, Brian D. Nicholson

Assessment of glycemia in chronic kidney disease

Mohamed Hassanein, Tariq Shafi

Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort

Manon Cairat, Sabina Rinaldi, Anne-Sophie Navionis, Isabelle Romieu, Carine Biessy, Vivian Viallon, Anja Olsen, Anne Tjønneland, Agnès Fournier, Gianluca Severi, Marina Kvaskoff, Renée T. Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Matthias B. Schulze, Giovanna Masala, Rosario Tumino, Sabina Sieri, Chiara Grasso, Amalia Mattiello, Inger T. Gram, Karina Standahl Olsen, Antonio Agudo, Pilar Amiano Etxezarreta, Maria-Jose Sánchez, Carmen Santiuste, Aurelio Barricarte, Evelyn Monninkhof, Anouk E. Hiensch, David Muller, Melissa A. Merritt, Ruth C. Travis, Elisabete Weiderpass, Marc J. Gunter, Laure Dossus

Impact of a delayed second dose of mRNA vaccine (BNT162b2) and inactivated SARS-CoV-2 vaccine (CoronaVac) on risks of all-cause mortality, emergency department visit, and unscheduled hospitalization

Carlos King Ho Wong, Xi Xiong, Kristy Tsz Kwan Lau, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Esther Wai Yin Chan, Eric Yuk Fai Wan, Ivan Chi Ho Au, Benjamin John Cowling, Cheuk Kwong Lee, Ian Chi Kei Wong

Organ-specific metastatic landscape dissects PD-(L)1 blockade efficacy in advanced non-small cell lung cancer: applicability from clinical trials to real-world practice

Si-Cong Ma, Xue Bai, Xue-Jun Guo, Li Liu, Lu-Shan Xiao, Yan Lin, Jia-Le Tan, Xiao-Ting Cai, Yu-Xiang Wen, Hu Ma, Q. John Fu, Meng-Xin Leng, Yan-Pei Zhang, Li-Li Long, Ze-Qin Guo, De-Hua Wu, Jian-Guo Zhou, Zhong-Yi Dong

Correction to: Lifetime risk of cardiovascular-renal disease in type 2 diabetes: a population-based study in 473,399 individuals

Ruiqi Zhang, Jil Billy Mamza, Tamsin Morris, George Godfrey, Folkert W. Asselbergs, Spiros Denaxas, Harry Hemingway, Amitava Banerjee

A healthy dietary metabolic signature is associated with a lower risk for type 2 diabetes and coronary artery disease

Einar Smith, Ulrika Ericson, Sophie Hellstrand, Marju Orho-Melander, Peter M. Nilsson, Céline Fernandez, Olle Melander, Filip Ottosson

The association of neurodevelopmental abnormalities, congenital heart and renal defects in a tuberous sclerosis complex patient cohort

Jessica Robinson, Orhan Uzun, Ne Ron Loh, Isabelle Rose Harris, Thomas E. Woolley, Adrian J. Harwood, Jennifer Frances Gardner, Yasir Ahmed Syed

Effects of providing free hearing aids on multiple health outcomes among middle-aged and older adults with hearing loss in rural China: a randomized controlled trial

Xin Ye, Dawei Zhu, Siyuan Chen, Xuefeng Shi, Rui Gong, Juncheng Wang, Huibin Zuo, Ping He

Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis

Emma Hazelwood, Eleanor Sanderson, Vanessa Y. Tan, Katherine S. Ruth, Timothy M. Frayling, Niki Dimou, Marc J. Gunter, Laure Dossus, Claire Newton, Neil Ryan, Dimitri J. Pournaras, Tracy A. O’Mara, George Davey Smith, Richard M. Martin, James Yarmolinsky

Correction to: P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss

Caiyun Ge, Dan Xu, Pengxia Yu, Man Fang, Juanjuan Guo, Dan Xu, Yuan Qiao, Sijia Chen, Yuanzhen Zhang, Hui Wang

Diabetic kidney disease and risk of incident stroke among adults with type 2 diabetes

Arnaud D. Kaze, Bernard G. Jaar, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui

AstraZeneca COVID-19 vaccine induces robust broadly cross-reactive antibody responses in Malawian adults previously infected with SARS-CoV-2

Marah G. Chibwana, Thandeka Moyo-Gwete, Gaurav Kwatra, Jonathan Mandolo, Tandile Hermanaus, Thopisang Motlou, Nonkululeko Mzindle, Frances Ayres, Mphatso Chaponda, Godwin Tembo, Percy Mwenechanya, Ndaona Mitole, Chisomo Jassi, Raphael Kamng’ona, Louise Afran, David Mzinza, Henry C. Mwandumba, Stephen B. Gordon, Khuzwayo Jere, Shabir Madhi, Penny L. Moore, Robert S. Heyderman, Kondwani C. Jambo

Recovery of serum testosterone levels is an accurate predictor of survival from COVID-19 in male patients

Emily Toscano-Guerra, Mónica Martínez-Gallo, Iria Arrese-Muñoz, Anna Giné, Noelia Díaz-Troyano, Pablo Gabriel-Medina, Mar Riveiro-Barciela, Moisés Labrador-Horrillo, Fernando Martinez-Valle, Adrián Sánchez Montalvá, Manuel Hernández-González, Ricardo Pujol Borrell, Francisco Rodríguez-Frias, Roser Ferrer, Timothy M. Thomson, Rosanna Paciucci

Global diversity of policy, coverage, and demand of COVID-19 vaccines: a descriptive study

Zhiyuan Chen, Wen Zheng, Qianhui Wu, Xinghui Chen, Cheng Peng, Yuyang Tian, Ruijia Sun, Jiayi Dong, Minghan Wang, Xiaoyu Zhou, Zeyao Zhao, Guangjie Zhong, Xuemei Yan, Nuolan Liu, Feiran Hao, Sihong Zhao, Tingyu Zhuang, Juan Yang, Andrew S. Azman, Hongjie Yu

Shared genetic links between frontotemporal dementia and psychiatric disorders

Chunyu Li, Dejiang Pang, Junyu Lin, Tianmi Yang, Huifang Shang

Time spent in outdoor light is associated with the risk of dementia: a prospective cohort study of 362094 participants

Ling-Zhi Ma, Ya-Hui Ma, Ya-Nan Ou, Shi-Dong Chen, Liu Yang, Qiang Dong, Wei Cheng, Lan Tan, Jin-Tai Yu

Mutations of PI3K-AKT-mTOR pathway as predictors for immune cell infiltration and immunotherapy efficacy in dMMR/MSI-H gastric adenocarcinoma

Zhenghang Wang, Xinyu Wang, Yu Xu, Jian Li, Xiaotian Zhang, Zhi Peng, Yajie Hu, Xinya Zhao, Kun Dong, Bei Zhang, Chan Gao, Xiaochen Zhao, Hui Chen, Jinping Cai, Yuezong Bai, Yu Sun, Lin Shen

Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people

Maria G. Kakkoura, Huaidong Du, Yu Guo, Canqing Yu, Ling Yang, Pei Pei, Yiping Chen, Sam Sansome, Wing Ching Chan, Xiaoming Yang, Lei Fan, Jun Lv, Junshi Chen, Liming Li, Timothy J. Key, Zhengming Chen, Junshi Chen, Zhengming Chen, Robert Clarke, Rory Collins, Yu Guo, Liming Li, Chen Wang, Jun Lv, Richard Peto, Robin Walters, Daniel Avery, Derrick Bennett, Ruth Boxall, Ka Hung Chan, Yumei Chang, Yiping Chen, Johnathan Clarke, Huaidong Du, Zammy Fairhurst-Hunter, Hannah Fry, Simon Gilbert, Alex Hacker, Mike Hill, Michael Holmes, Pek Kei Im, Andri Iona, Maria Kakkoura, Christiana Kartsonaki, Rene Kerosi, Kuang Lin, Mohsen Mazidi, Iona Millwood, Qunhua Nie, Alfred Pozarickij, Paul Ryder, Saredo Said, Sam Sansome, Dan Schmidt, Paul Sherliker, Rajani Sohoni, Becky Stevens, Iain Turnbull, Lin Wang, Neil Wright, Ling Yang, Xiaoming Yang, Pang Yao, Xiao Han, Can Hou, Qingmei Xia, Chao Liu, Pei Pei, Canqing Yu, Naying Chen, Duo Liu, Zhenzhu Tang, Ningyu Chen, Qilian Jiang, Jian Lan, Mingqiang Li, Yun Liu, Fanwen Meng, Jinhuai Meng, Rong Pan, Yulu Qin, Ping Wang, Sisi Wang, Liuping Wei, Liyuan Zhou, Caixia Dong, Pengfei Ge, Xiaolan Ren, Zhongxiao Li, Enke Mao, Tao Wang, Hui Zhang, Xi Zhang, Jinyan Chen, Ximin Hu, Xiaohuan Wang, Zhendong Guo, Huimei Li, Yilei Li, Min Weng, Shukuan Wu, Shichun Yan, Mingyuan Zou, Xue Zhou, Ziyan Guo, Quan Kang, Yanjie Li, Bo Yu, Qinai Xu, Liang Chang, Lei Fan, Shixian Feng, Ding Zhang, Gang Zhou, Yulian Gao, Tianyou He, Pan He, Chen Hu, Huarong Sun, Xukui Zhang, Biyun Chen, Zhongxi Fu, Yuelong Huang, Huilin Liu, Qiaohua Xu, Li Yin, Huajun Long, Xin Xu, Hao Zhang, Libo Zhang, Jian Su, Ran Tao, Ming Wu, Jie Yang, Jinyi Zhou, Yonglin Zhou, Yihe Hu, Yujie Hua, Jianrong Jin Fang Liu, Jingchao Liu, Yan Lu, Liangcai Ma, Aiyu Tang, Jun Zhang, Liang Cheng, Ranran Du, Ruqin Gao, Feifei Li, Shanpeng Li, Yongmei Liu, Feng Ning, Zengchang Pang, Xiaohui Sun, Xiaocao Tian, Shaojie Wang, Yaoming Zhai, Hua Zhang, Wei Hou, Silu Lv, Junzheng Wang, Xiaofang Chen, Xianping Wu, Ningmei Zhang, Weiwei Zhou, Jianguo Li, Jiaqiu Liu, Guojin Luo, Qiang Sun, Xunfu Zhong, Weiwei Gong, Ruying Hu, Hao Wang, Meng Wan, Min Yu, Lingli Chen, Qijun Gu, Dongxia Pan, Chunmei Wang, Kaixu Xie, Xiaoyi Zhang

The potential impact of Anopheles stephensi establishment on the transmission of Plasmodium falciparum in Ethiopia and prospective control measures

Arran Hamlet, Dereje Dengela, J. Eric Tongren, Fitsum G. Tadesse, Teun Bousema, Marianne Sinka, Aklilu Seyoum, Seth R. Irish, Jennifer S. Armistead, Thomas Churcher

Immune microenvironment, homologous recombination deficiency, and therapeutic response to neoadjuvant chemotherapy in triple-negative breast cancer: Japan Breast Cancer Research Group (JBCRG)22 TR

Takayuki Ueno, Shigehisa Kitano, Norikazu Masuda, Daiki Ikarashi, Makiko Yamashita, Tomohiro Chiba, Takayuki Kadoya, Hiroko Bando, Takashi Yamanaka, Shoichiro Ohtani, Shigenori Nagai, Takahiro Nakayama, Masato Takahashi, Shigehira Saji, Kenjiro Aogi, Ravi Velaga, Kosuke Kawaguchi, Satoshi Morita, Hironori Haga, Shinji Ohno, Masakazu Toi

Autism spectrum disorders as a risk factor for adolescent self-harm: a retrospective cohort study of 113,286 young people in the UK

Emily Widnall, Sophie Epstein, Catherine Polling, Sumithra Velupillai, Amelia Jewell, Rina Dutta, Emily Simonoff, Robert Stewart, Ruth Gilbert, Tamsin Ford, Matthew Hotopf, Richard D. Hayes, Johnny Downs

Healthy lifestyle counteracts the risk effect of genetic factors on incident gout: a large population-based longitudinal study

Yuan Zhang, Rongrong Yang, Abigail Dove, Xuerui Li, Hongxi Yang, Shu Li, Ju Wang, Wei-Dong Li, Hongyu Zhao, Weili Xu, Yaogang Wang

Dietary fibre in hypertension and cardiovascular disease management: systematic review and meta-analyses

Andrew N. Reynolds, Ashley Akerman, Shiristi Kumar, Huyen Tran Diep Pham, Sean Coffey, Jim Mann

Prophylactic NAC promoted hematopoietic reconstitution by improving endothelial cells after haploidentical HSCT: a phase 3, open-label randomized trial

Yu Wang, Yuan Kong, Hong-Yan Zhao, Yuan-Yuan Zhang, Ya-Zhe Wang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang

Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth

Heli Tiensuu, Antti M. Haapalainen, Pinja Tissarinen, Anu Pasanen, Tomi A. Määttä, Johanna M. Huusko, Steffen Ohlmeier, Ulrich Bergmann, Marja Ojaniemi, Louis J. Muglia, Mikko Hallman, Mika Rämet

Distinct clinical and somatic mutational features of breast tumors with high-, low-, or non-expressing human epidermal growth factor receptor 2 status

Guochun Zhang, Chongyang Ren, Cheukfai Li, Yulei Wang, Bo Chen, Lingzhu Wen, Minghan Jia, Kai Li, Hsiaopei Mok, Li Cao, Xiaoqing Chen, Jiali Lin, Guangnan Wei, Yingzhi Li, Yuchen Zhang, Charles M. Balch, Ning Liao

Adiposity and risk of prostate cancer death: a prospective analysis in UK Biobank and meta-analysis of published studies

Aurora Perez-Cornago, Yashvee Dunneram, Eleanor L. Watts, Timothy J. Key, Ruth C. Travis

Etiological spectrum of persistent fever in the tropics and predictors of ubiquitous infections: a prospective four-country study with pooled analysis

Emmanuel Bottieau, Lukas Van Duffel, Sayda El Safi, Kanika Deshpande Koirala, Basudha Khanal, Suman Rijal, Narayan Raj Bhattarai, Thong Phe, Kruy Lim, Deby Mukendi, Jean-Roger Lilo Kalo, Pascal Lutumba, Barbara Barbé, Jan Jacobs, Marjan Van Esbroeck, Nikki Foqué, Achilleas Tsoumanis, Philippe Parola, Cedric P. Yansouni, Marleen Boelaert, Kristien Verdonck, François Chappuis

Prospective association of dietary soy and fibre intake with puberty timing: a cohort study among Chinese children

Jingyuan Xiong, Yujie Xu, Xueting Liu, Xiaoyu Wang, Shufang Shan, M. James C. Crabbe, Li Zhao, He Fang, Guo Cheng

CoronaVac vaccine is effective in preventing symptomatic and severe COVID-19 in pregnant women in Brazil: a test-negative case-control study

Enny S. Paixao, Kerry L. M. Wong, Flavia Jôse Oliveira Alves, Vinicius de Araújo Oliveira, Thiago Cerqueira-Silva, Juracy Bertoldo Júnior, Tales Mota Machado, Elzo Pereira Pinto Junior, Viviane S. Boaventura, Gerson O. Penna, Guilherme Loureiro Werneck, Laura C. Rodrigues, Neil Pearce, Mauricio L. Barreto, Manoel Barral-Netto

The UK Coronavirus Job Retention Scheme and diet, physical activity, and sleep during the COVID-19 pandemic: evidence from eight longitudinal population surveys

Bożena Wielgoszewska, Jane Maddock, Michael J. Green, Giorgio Di Gessa, Sam Parsons, Gareth J. Griffith, Jazz Croft, Anna J. Stevenson, Charlotte Booth, Richard J. Silverwood, David Bann, Praveetha Patalay, Alun D. Hughes, Nishi Chaturvedi, Laura D. Howe, Emla Fitzsimons, Srinivasa Vittal Katikireddi, George B. Ploubidis

Ketone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway

Chongyang Huang, Jun Wang, Hongbin Liu, Ruo Huang, Xinwen Yan, Mengyao Song, Gao Tan, Fachao Zhi

Ethnic differences in cardiovascular risk: examining differential exposure and susceptibility to risk factors

Frederick K. Ho, Stuart R. Gray, Paul Welsh, Jason M. R. Gill, Naveed Sattar, Jill P. Pell, Carlos Celis-Morales

Barriers to management of opioid withdrawal in hospitals in England: a document analysis of hospital policies on the management of substance dependence

Magdalena Harris, Adam Holland, Dan Lewer, Michael Brown, Niamh Eastwood, Gary Sutton, Ben Sansom, Gabby Cruickshank, Molly Bradbury, Isabelle Guest, Jenny Scott

Predictive performance of a competing risk cardiovascular prediction tool CRISK compared to QRISK3 in older people and those with comorbidity: population cohort study

Shona J. Livingstone, Bruce Guthrie, Peter T. Donnan, Alexander Thompson, Daniel R. Morales

Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models: implications for risk stratification

Peh Joo Ho, Weang Kee Ho, Alexis J. Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong, Wei Sean Yong, Chin Mui Seah, Siau Wei Tang, Celene Wei Qi Ng, Zhiyan Yan, Jung Ah Lee, Kartini Rahmat, Tania Islam, Tiara Hassan, Mei-Chee Tai, Chiea Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Xueling Sim, Alison M. Dunning, Manjeet K. Bolla, Antonis C. Antoniou, Soo-Hwang Teo, Jingmei Li, Mikael Hartman

Impact of prenatal tobacco smoking on infant telomere length trajectory and ADHD symptoms at 18 months: a longitudinal cohort study

Meghan P. Howell, Christopher W. Jones, Cade A. Herman, Celia V. Mayne, Camilo Fernandez, Katherine P. Theall, Kyle C. Esteves, Stacy S. Drury

Apatinib in patients with recurrent or metastatic thymic epithelial tumor: a single-arm, multicenter, open-label, phase II trial

Zhengbo Song, Guangyuan Lou, Yina Wang, Zhiping Yang, Wenxian Wang, Yongling Ji, Shiqing Chen, Chunwei Xu, Xiao Hu, Yiping Zhang

Phase II study of anlotinib in combination with oxaliplatin and capecitabine for patients with RAS/BRAF wild-type metastatic colorectal adenocarcinoma as the first-line therapy

Yue Liu, Qian Xiao, Jinjie He, Hanguang Hu, Jinlin Du, Yuping Zhu, Jiaqi Chen, Zhuo Liu, Jianping Wang, Lifeng Sun, Dong Xu, Jun Li, Xiujun Liao, Jianwei Wang, Yibo Cai, Cheng Cai, Zhekang Jin, Liuhong Wang, Ying Yuan, Kefeng Ding

Predicting the earliest deviation in weight gain in the course towards manifest overweight in offspring exposed to obesity in pregnancy: a longitudinal cohort study

Delphina Gomes, Lien Le, Sarah Perschbacher, Nikolaus A. Haas, Heinrich Netz, Uwe Hasbargen, Maria Delius, Kristin Lange, Uta Nennstiel, Adelbert A. Roscher, Ulrich Mansmann, Regina Ensenauer

Opening up safely: public health system requirements for ongoing COVID-19 management based on evaluation of Australia’s surveillance system performance

Kamalini Lokuge, Katina D’Onise, Emily Banks, Tatum Street, Sydney Jantos, Mohana Baptista, Kathryn Glass

Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood

Júlia Vallvé-Juanico, Ashley F. George, Sushmita Sen, Reuben Thomas, Min-Gyoung Shin, Divyashree Kushnoor, Joshua J. Vásquez, Kim Chi Vo, Juan C. Irwin, Nadia R. Roan, Alexis J. Combes, Linda C. Giudice

Predictive value of circulating NMR metabolic biomarkers for type 2 diabetes risk in the UK Biobank study

Fiona Bragg, Eirini Trichia, Diego Aguilar-Ramirez, Jelena Bešević, Sarah Lewington, Jonathan Emberson

Reliability analysis of exonic-breakpoint fusions identified by DNA sequencing for predicting the efficacy of targeted therapy in non-small cell lung cancer

Weihua Li, Rui Wan, Lei Guo, Geyun Chang, Dong Jiang, Lin Meng, Jianming Ying

Is glycaemic control associated with dietary patterns independent of weight change in people newly diagnosed with type 2 diabetes? Prospective analysis of the Early-ACTivity-In-Diabetes trial

James Garbutt, C. England, A. G. Jones, R. C. Andrews, R. Salway, L. Johnson

A deep learning approach identifies new ECG features in congenital long QT syndrome

Simona Aufiero, Hidde Bleijendaal, Tomas Robyns, Bert Vandenberk, Christian Krijger, Connie Bezzina, Aeilko H. Zwinderman, Arthur A. M. Wilde, Yigal M. Pinto

Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of fragile X syndrome

Sahar Javadi, Yue Li, Jie Sheng, Lucy Zhao, Yao Fu, Daifeng Wang, Xinyu Zhao

Survival among people hospitalized with COVID-19 in Switzerland: a nationwide population-based analysis

Nanina Anderegg, Radoslaw Panczak, Matthias Egger, Nicola Low, Julien Riou

Environmental pesticide exposure and non-Hodgkin lymphoma survival: a population-based study

Christina Poh, John D. McPherson, Joseph Tuscano, Qian Li, Arti Parikh-Patel, Christoph F. A. Vogel, Myles Cockburn, Theresa Keegan

Imagery ability assessments: a cross-disciplinary systematic review and quality evaluation of psychometric properties

Zorica Suica, Frank Behrendt, Szabina Gäumann, Ulrich Gerth, Arno Schmidt-Trucksäss, Thierry Ettlin, Corina Schuster-Amft

The COVID-19 pandemic in the African continent

Godfrey Bwire, Alex Riolexus Ario, Patricia Eyu, Felix Ocom, Joseph F. Wamala, Kwadwo A. Kusi, Latif Ndeketa, Kondwani C. Jambo, Rhoda K. Wanyenze, Ambrose O. Talisuna

Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study

Junyi Xin, Xia Jiang, Shuai Ben, Qianyu Yuan, Li Su, Zhengdong Zhang, David C. Christiani, Mulong Du, Meilin Wang

Comprehensive and integrative analyses identify TYW5 as a schizophrenia risk gene

Chengcheng Zhang, Xiaojing Li, Liansheng Zhao, Rong Liang, Wei Deng, Wanjun Guo, Qiang Wang, Xun Hu, Xiangdong Du, Pak Chung Sham, Xiongjian Luo, Tao Li

ctDNA-adjusted bTMB as a predictive biomarker for patients with NSCLC treated with PD-(L)1 inhibitors

Wei Nie, Zhi-Jie Wang, Kai Zhang, Bing Li, Yi-Ran Cai, Feng-Cai Wen, Ding Zhang, Yue-Zong Bai, Xue-Yan Zhang, Shu-Yuan Wang, Lei Cheng, Hua Zhong, Li Liu, Jie Wang, Bao-Hui Han

Temporal relationship among adiposity, gut microbiota, and insulin resistance in a longitudinal human cohort

Kui Deng, Menglei Shuai, Zheqing Zhang, Zengliang Jiang, Yuanqing Fu, Luqi Shen, Ju-Sheng Zheng, Yu-ming Chen

Leaving no one behind: targeting mobile and migrant populations with health interventions for disease elimination—a descriptive systematic review

Molly W Adams, Elizabeth G Sutherland, Erin L Eckert, Khalida Saalim, Richard Reithinger

Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections

Sanjeevan Jahagirdar, Lorna Morris, Nirupama Benis, Oddvar Oppegaard, Mattias Svenson, Ole Hyldegaard, Steinar Skrede, Anna Norrby-Teglund, Trond Bruun, Eivind Rath, Torbjørn Nedrebø, Per Arnell, Anders Rosen, Morten Hedetoft, Martin B. Madsen, Mattias Svensson, Johanna Snäll, Ylva Karlsson, Michael Nekludov, Vitor A. P. Martins dos Santos, Edoardo Saccenti

Evaluating agreement between bodies of evidence from randomized controlled trials and cohort studies in medical research: a meta-epidemiological study

Nils Bröckelmann, Sara Balduzzi, Louisa Harms, Jessica Beyerbach, Maria Petropoulou, Charlotte Kubiak, Martin Wolkewitz, Joerg J. Meerpohl, Lukas Schwingshackl

Palbociclib-based high-throughput combination drug screening identifies synergistic therapeutic options in HPV-negative head and neck squamous cell carcinoma

Ziyue Gu, Chaoji Shi, Jiayi Li, Yong Han, Bao Sun, Wuchang Zhang, Jing Wu, Guoyu Zhou, Weimin Ye, Jiang Li, Zhiyuan Zhang, Rong Zhou

Effectiveness of a digital intervention versus alcohol information for online help-seekers in Sweden: a randomised controlled trial

Marcus Bendtsen, Katarina Åsberg, Jim McCambridge

Data-sharing and re-analysis for main studies assessed by the European Medicines Agency—a cross-sectional study on European Public Assessment Reports

Maximilian Siebert, Jeanne Gaba, Alain Renault, Bruno Laviolle, Clara Locher, David Moher, Florian Naudet

Associations of face-to-face and non-face-to-face social isolation with all-cause and cause-specific mortality: 13-year follow-up of the Guangzhou Biobank Cohort study

Jiao Wang, Wei Sen Zhang, Chao Qiang Jiang, Feng Zhu, Ya Li Jin, Kar Keung Cheng, Tai Hing Lam, Lin Xu

Correction: Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy

Justyna Mączyńska, Florian Raes, Chiara Da Pieve, Stephen Turnock, Jessica K. R. Boult, Julia Hoebart, Marcin Niedbala, Simon P. Robinson, Kevin J. Harrington, Wojciech Kaspera, Gabriela Kramer-Marek

Correction: HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis

Xiaoyu Xie, Huanran Lv, Chenxi Liu, Xiaonan Su, Zhen Yu, Shouyang Song, Hongjun Bian, Miaomiao Tian, Chengyong Qin, Jianni Qi, Qiang Zhu

Broad humoral and cellular immunity elicited by one-dose mRNA vaccination 18 months after SARS-CoV-2 infection

Chang Kyung Kang, Hyun Mu Shin, Pyoeng Gyun Choe, Jiyoung Park, Jisu Hong, Jung Seon Seo, Yung Hie Lee, Euijin Chang, Nam Joong Kim, Minji Kim, Yong-Woo Kim, Hang-Rae Kim, Chang-Han Lee, Jun-Young Seo, Wan Beom Park, Myoung-don Oh

Prioritising attributes for tuberculosis preventive treatment regimens: a modelling analysis

Juan F. Vesga, Christian Lienhardt, Placide Nsengiyumva, Jonathon R. Campbell, Olivia Oxlade, Saskia den Boon, Dennis Falzon, Kevin Schwartzman, Gavin Churchyard, Nimalan Arinaminpathy

Ten years of tracking mental health in refugee primary health care settings: an updated analysis of data from UNHCR’s Health Information System (2009–2018)

Shoshanna L. Fine, Jeremy C. Kane, Paul B. Spiegel, Wietse A. Tol, Peter Ventevogel

Structured reporting to improve transparency of analyses in prognostic marker studies

Willi Sauerbrei, Tim Haeussler, James Balmford, Marianne Huebner

Temporal trajectories of important diseases in the life course and premature mortality in the UK Biobank

Xianwen Shang, Xueli Zhang, Yu Huang, Zhuoting Zhu, Xiayin Zhang, Shunming Liu, Jiahao Liu, Shulin Tang, Wei Wang, Honghua Yu, Zongyuan Ge, Mingguang He

The impact of medication reviews by general practitioners on psychotropic drug use and behavioral and psychological symptoms in home-dwelling people with dementia: results from the multicomponent cluster randomized controlled LIVE@Home.Path trial

Marie H. Gedde, Bettina S. Husebo, Janne Mannseth, Mala Naik, Geir Selbaek, Maarja Vislapuu, Line Iden Berge

Systematic analysis of IL-6 as a predictive biomarker and desensitizer of immunotherapy responses in patients with non-small cell lung cancer

Chengming Liu, Lu Yang, Haiyan Xu, Sufei Zheng, Zhanyu Wang, Sihui Wang, Yaning Yang, Shuyang Zhang, Xiaoli Feng, Nan Sun, Yan Wang, Jie He

Genetic susceptibility, screen-based sedentary activities and incidence of coronary heart disease

Youngwon Kim, Shiu Lun Au Yeung, Stephen J. Sharp, Mengyao Wang, Haeyoon Jang, Shan Luo, Soren Brage, Katrien Wijndaele

Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth

Ya-nan Zhu, Xiao-wen Gan, Fan Pan, Xiao-tian Ni, Leslie Myatt, Wang-sheng Wang, Kang Sun

Intermittent screening and treatment for malaria complementary to routine immunisation in the first year of life in Papua, Indonesia: a cluster randomised superiority trial

Jeanne Rini Poespoprodjo, Hafiidhaturrahmah, Novita Sariyanti, Ratni Indrawanti, Alistair R. D. McLean, Julie A. Simpson, Enny Kenangalem, Faustina Helena Burdam, Rintis Noviyanti, Leily Trianty, Chairunisa Fadhilah, Yati Soenarto, Ric N. Price

Associations of handgrip strength with morbidity and all-cause mortality of cardiometabolic multimorbidity

Yanqiang Lu, Guochen Li, Pietro Ferrari, Heinz Freisling, Yanan Qiao, Luying Wu, Liping Shao, Chaofu Ke

Intake of whole grain foods and risk of coronary heart disease in US men and women

Yang Hu, Walter C. Willett, Jo Ann E. Manson, Bernard Rosner, Frank B. Hu, Qi Sun

Comparing efficacy and safety in catheter ablation strategies for atrial fibrillation: a network meta-analysis

Emmanouil Charitakis, Silvia Metelli, Lars O. Karlsson, Antonios P. Antoniadis, Konstantinos D. Rizas, Ioan Liuba, Henrik Almroth, Anders Hassel Jönsson, Jonas Schwieler, Dimitrios Tsartsalis, Skevos Sideris, Elena Dragioti, Nikolaos Fragakis, Anna Chaimani

Role of diet in stroke incidence: an umbrella review of meta-analyses of prospective observational studies

Na Guo, Ying Zhu, Dandan Tian, Yating Zhao, Chenguang Zhang, Changqing Mu, Chen Han, Ruixia Zhu, Xu Liu

The effectiveness of the Structured Health Intervention For Truckers (SHIFT): a cluster randomised controlled trial (RCT)

Stacy A. Clemes, Veronica Varela-Mato, Danielle H. Bodicoat, Cassandra L. Brookes, Yu-Ling Chen, Charlotte L. Edwardson, Laura J. Gray, Amber J. Guest, Vicki Johnson, Fehmidah Munir, Nicola J. Paine, Gerry Richardson, Katharina Ruettger, Mohsen Sayyah, Aron Sherry, Ana Suazo Di Paola, Jacqui Troughton, Thomas Yates, James A. King

An assessment of the vaccination of school-aged children in England against SARS-CoV-2

Matt J. Keeling, Sam E. Moore

Subsequent treatments beyond progression on osimertinib in EGFR-mutated NSCLC and leptomeningeal metastases

Mei-Mei Zheng, Yang-Si Li, Hai-Yan Tu, Hao Sun, Kai Yin, Ben-Yuan Jiang, Jin-Ji Yang, Xu-Chao Zhang, Qing Zhou, Chong-Rui Xu, Zhen Wang, Hua-Jun Chen, De-Xiang Zhou, Yi-Long Wu

Intelligence outcome of pediatric intensive care unit survivors: a systematic meta-analysis and meta-regression

Eleonore S. V. de Sonnaville, Marsh Kӧnigs, Ouke van Leijden, Hennie Knoester, Job B. M. van Woensel, Jaap Oosterlaan

Effectiveness of COVID-19 vaccines against SARS-CoV-2 variants of concern: a systematic review and meta-analysis

Baoqi Zeng, Le Gao, Qingxin Zhou, Kai Yu, Feng Sun

Time trends in social contacts of individuals according to comorbidity and vaccination status, before and during the COVID-19 pandemic

Aurélie Godbout, Mélanie Drolet, Myrto Mondor, Marc Simard, Chantal Sauvageau, Gaston De Serres, Marc Brisson

Adiposity and grip strength: a Mendelian randomisation study in UK Biobank

Snehal M. Pinto Pereira, Victoria Garfield, Aliki-Eleni Farmaki, David J. Tomlinson, Thomas Norris, Ghazaleh Fatemifar, Spiros Denaxas, Chris Finan, Rachel Cooper

Projecting vaccine demand and impact for emerging zoonotic pathogens

Anita Lerch, Quirine A. ten Bosch, Maïna L’Azou Jackson, Alison A. Bettis, Mauro Bernuzzi, Georgina A. V. Murphy, Quan M. Tran, John H. Huber, Amir S. Siraj, Gebbiena M. Bron, Margaret Elliott, Carson S. Hartlage, Sojung Koh, Kathyrn Strimbu, Magdalene Walters, T. Alex Perkins, Sean M. Moore

Associations of genetic risk, BMI trajectories, and the risk of non-small cell lung cancer: a population-based cohort study

Dongfang You, Danhua Wang, Yaqian Wu, Xin Chen, Fang Shao, Yongyue Wei, Ruyang Zhang, Theis Lange, Hongxia Ma, Hongyang Xu, Zhibin Hu, David C. Christiani, Hongbing Shen, Feng Chen, Yang Zhao

Gut microbiota signatures of long-term and short-term plant-based dietary pattern and cardiometabolic health: a prospective cohort study

Zelei Miao, Wenwen Du, Congmei Xiao, Chang Su, Wanglong Gou, Luqi Shen, Jiguo Zhang, Yuanqing Fu, Zengliang Jiang, Zhihong Wang, Xiaofang Jia, Ju-Sheng Zheng, Huijun Wang

Observational study of population genomic screening for variants associated with endocrine tumor syndromes in a large, healthcare-based cohort

Juliann M. Savatt, Nicole M. Ortiz, Gretchen M. Thone, Whitney S. McDonald, Melissa A. Kelly, Alexander S. F. Berry, Madiha M. Alvi, Miranda L. G. Hallquist, Jennifer Malinowski, Nicholas C. Purdy, Marc S. Williams, Amy C. Sturm, Adam H. Buchanan

Targeted RNA next generation sequencing analysis of cervical smears can predict the presence of hrHPV-induced cervical lesions

Karolina M. Andralojc, Duaa Elmelik, Menno Rasing, Bernard Pater, Albert G. Siebers, Ruud Bekkers, Martijn A. Huynen, Johan Bulten, Diede Loopik, Willem J. G. Melchers, William P. J. Leenders

Biological aging mediates the associations between urinary metals and osteoarthritis among U.S. adults

Li Chen, Ying Zhao, Fangqu Liu, Huimin Chen, Tianqi Tan, Ping Yao, Yuhan Tang

Clinical benefit of systolic blood pressure within the target range among patients with or without diabetes mellitus: a propensity score-matched analysis of two randomized clinical trials

Chao Li, Kangyu Chen, Guoshuai Shi, Rui Shi, Zhenqiang Wu, Xiaodan Yuan, Vicky Watson, Zhixin Jiang, Hui Mai, Tian Yang, Duolao Wang, Tao Chen

Genetic factors for survival in amyotrophic lateral sclerosis: an integrated approach combining a systematic review, pairwise and network meta-analysis

Wei-Ming Su, Xiao-Jing Gu, Qing-Qing Duan, Zheng Jiang, Xia Gao, Hui-Fang Shang, Yong-Ping Chen

Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants

Maria Carolina Borges, Philip C. Haycock, Jie Zheng, Gibran Hemani, Michael V. Holmes, George Davey Smith, Aroon D. Hingorani, Deborah A. Lawlor

Identification of novel proteins for lacunar stroke by integrating genome-wide association data and human brain proteomes

Chengcheng Zhang, Fengqin Qin, Xiaojing Li, Xiangdong Du, Tao Li

STOP— a training intervention to optimise treatment for smoking cessation in community pharmacies: cluster randomised controlled trial

Sandra Jumbe, Vichithranie W. Madurasinghe, Wai Yee James, Colin Houlihan, Samantha L. Jumbe, Tammy Yau, Florian Tomini, Sandra Eldridge, Borislava Mihaylova, Liz Steed, Ratna Sohanpal, Darush Attar, Stephanie J. C. Taylor, Chris Griffiths, Robert Walton

Length of initial prescription at hospital discharge and long-term medication adherence for elderly, post-myocardial infarction patients: a population-based interrupted time series study

J. D. Schwalm, Noah M. Ivers, Zachary Bouck, Monica Taljaard, Madhu K. Natarajan, Francis Nguyen, Waseem Hijazi, Kednapa Thavorn, Lisa Dolovich, Tara McCready, Erin O’Brien, Jeremy M. Grimshaw

Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysis

Ping Guo, Weiming Gong, Yuanming Li, Lu Liu, Ran Yan, Yanjun Wang, Yanan Zhang, Zhongshang Yuan

Elevated levels of body mass index and waist circumference, but not high variability, are associated with an increased risk of atrial fibrillation

Maoxiang Zhao, Lulu Song, Qianqian Zhao, Yating Chen, Bin Li, Zhonghui Xie, Zihao Fu, Nan Zhang, Xiaowei Cheng, Xiaoqian Li, Miao Wang, Shouling Wu, Hao Xue, Yang Li

Serological study of CoronaVac vaccine and booster doses in Chile: immunogenicity and persistence of anti-SARS-CoV-2 spike antibodies

Leonardo Vargas, Nicolás Valdivieso, Fabián Tempio, Valeska Simon, Daniela Sauma, Lucía Valenzuela, Caroll Beltrán, Loriana Castillo-Delgado, Ximena Contreras-Benavides, Mónica L. Acevedo, Johanna Acevedo, Rafael I. Gonzalez, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Mario Rosemblatt, Mercedes Lopez, Fabiola Osorio, María Rosa Bono

Number of standard modifiable risk factors and mortality in patients with first-presentation ST-segment elevation myocardial infarction: insights from China Acute Myocardial Infarction registry

Sidong Li, Xiaojin Gao, Jingang Yang, Haiyan Xu, Yang Wang, Yanyan Zhao, Lu Yin, Chao Wu, Yi Wang, Yang Zheng, Bao Li, Xuan Zhang, Yunqing Ye, Rui Fu, Qiuting Dong, Hui Sun, Xinxin Yan, Yuan Wu, Jun Zhang, Chen Jin, Wei Li, Yuejin Yang

Plasma neurofilament light and its association with all-cause mortality risk among urban middle-aged men and women

May A. Beydoun, Nicole Noren Hooten, Jordan Weiss, Hind A. Beydoun, Sharmin Hossain, Michele K. Evans, Alan B. Zonderman

Risk and benefit for umbrella trials in oncology: a systematic review and meta-analysis

Karolina Strzebonska, Mateusz Blukacz, Mateusz T. Wasylewski, Maciej Polak, Bishal Gyawali, Marcin Waligora

Revisiting the seven pillars of RDoC

Sarah E. Morris, Charles A. Sanislow, Jenni Pacheco, Uma Vaidyanathan, Joshua A. Gordon, Bruce N. Cuthbert

Blackwater fever and acute kidney injury in children hospitalized with an acute febrile illness: pathophysiology and prognostic significance

Andrea L. Conroy, Michael T. Hawkes, Aleksandra Leligdowicz, Ivan Mufumba, Michelle C. Starr, Kathleen Zhong, Sophie Namasopo, Chandy C. John, Robert O. Opoka, Kevin C. Kain

DNA methylation subtypes guiding prognostic assessment and linking to responses the DNA methyltransferase inhibitor SGI-110 in urothelial carcinoma

Juan Li, Yuan Liang, Jian Fan, Chunru Xu, Bao Guan, Jianye Zhang, Bin Guo, Yue Shi, Ping Wang, Yezhen Tan, Qi Zhang, Changwei Yuan, Yucai Wu, Liqun Zhou, Weimin Ci, Xuesong Li

Multiplex immunohistochemistry defines the tumor immune microenvironment and immunotherapeutic outcome in CLDN18.2-positive gastric cancer

Keren Jia, Yang Chen, Yu Sun, Yajie Hu, Lei Jiao, Jie Ma, Jiajia Yuan, Changsong Qi, Yanyan Li, Jifang Gong, Jing Gao, Xiaotian Zhang, Jian Li, Cheng Zhang, Lin Shen

Homelessness and health-related outcomes: an umbrella review of observational studies and randomized controlled trials

Michele Fornaro, Elena Dragioti, Michele De Prisco, Martina Billeci, Anna Maria Mondin, Raffaella Calati, Lee Smith, Simon Hatcher, Mark Kaluzienski, Jess G. Fiedorowicz, Marco Solmi, Andrea de Bartolomeis, André F. Carvalho

International surveillance study in acute spinal cord injury confirms viability of multinational clinical trials

Lucie Bourguignon, Bobo Tong, Fred Geisler, Martin Schubert, Frank Röhrich, Marion Saur, Norbert Weidner, Rüdiger Rupp, Yorck-Bernhard B. Kalke, Rainer Abel, Doris Maier, Lukas Grassner, Harvinder S. Chhabra, Thomas Liebscher, Jacquelyn J. Cragg, John Kramer, Armin Curt, Catherine R. Jutzeler

A positive faecal immunochemical test result and its association with the incidence of rheumatoid arthritis, systemic lupus erythematosus, and psoriatic arthritis: an analysis of one-million national colorectal cancer screening programme results

Choong-Kyun Noh, Eunyoung Lee, Bumhee Park, Sung Soo Ahn

Associations of thiazide use with skin cancers: a systematic review and meta-analysis

Shih-Chieh Shao, Chien-Cheng Lai, Yi-Hung Chen, Edward Chia-Cheng Lai, Ming-Jui Hung, Ching-Chi Chi

Placenta-derived proteins across gestation in healthy pregnancies—a novel approach to assess placental function?

Maren-Helene Langeland Degnes, Ane Cecilie Westerberg, Manuela Zucknick, Theresa L. Powell, Thomas Jansson, Tore Henriksen, Marie Cecilie Paasche Roland, Trond Melbye Michelsen

Patient outcomes following AKI and AKD: a population-based cohort study

Huan Wang, Emilie Lambourg, Bruce Guthrie, Daniel R. Morales, Peter T. Donnan, Samira Bell

Investigation of CD4 and CD8 T cell-mediated protection against influenza A virus in a cohort study

Tim K. Tsang, Kwok-Tai Lam, Yinping Liu, Vicky J. Fang, Xiaofeng Mu, Nancy H. L. Leung, J. S. Malik Peiris, Gabriel M. Leung, Benjamin J. Cowling, Wenwei Tu

A novel CREB5/TOP1MT axis confers cisplatin resistance through inhibiting mitochondrial apoptosis in head and neck squamous cell carcinoma

Tong Tong, Xing Qin, Yingying Jiang, Haiyan Guo, Xiaoning Wang, Yan Li, Fei Xie, Hao Lu, Peisong Zhai, Hailong Ma, Jianjun Zhang

Association of ideal cardiovascular health with cardiovascular events and risk advancement periods in a Mediterranean population-based cohort

Cesar I. Fernandez-Lazaro, Carmen Sayon-Orea, Estefania Toledo, Conchi Moreno-Iribas, María J. Guembe, Joaquín Barba Cosials, Jesús Berjón Reyero, Javier Díez Martínez, Paulino González Diego, Ana Mª. Grijalba Uche, David Guerrero Setas, Eduardo Martínez Vila, Manuel Serrano Martínez, Isabel Sobejano Tornos, José Javier Viñes Rueda

Is living in a household with children associated with SARS-CoV-2 seropositivity in adults? Results from the Swiss national seroprevalence study Corona Immunitas

Jacob Blankenberger, Marco Kaufmann, Emiliano Albanese, Rebecca Amati, Daniela Anker, Anne-Linda Camerini, Patricia Chocano-Bedoya, Stéphane Cullati, Alexia Cusini, Jan Fehr, Erika Harju, Philipp Kohler, Susi Kriemler, Gisela Michel, Nicolas Rodondi, Pierre-Yves Rodondi, Alexandre Speierer, Stefano Tancredi, Milo A. Puhan, Christian R. Kahlert

Costs of multimorbidity: a systematic review and meta-analyses

Phuong Bich Tran, Joseph Kazibwe, Georgios F. Nikolaidis, Ismo Linnosmaa, Mieke Rijken, Josefien van Olmen

Severe inflammation in new-borns induces long-term cognitive impairment by activation of IL-1β/KCC2 signaling during early development

Donghang Zhang, Yujiao Yang, Yaoxin Yang, Jin Liu, Tao Zhu, Han Huang, Cheng Zhou

External validation of inpatient neonatal mortality prediction models in high-mortality settings

Timothy Tuti, Gary Collins, Mike English, George Mbevi, John Wainaina, Livingstone Mumelo, Edith Gicheha, Naomi Muinga, Muthoni Ogola, Laura Oyiengo, Caroline Mwangi, Fred Were, Juma Vitalis, Nyumbile Bonface, Roselyne Malangachi, Christine Manyasi, Catherine Mutinda, David Kibiwott Kimutai, Rukia Aden, Caren Emadau, Elizabeth Atieno Jowi, Cecilia Muithya, Charles Nzioki, Supa Tunje, Penina Musyoka, Wagura Mwangi, Agnes Mithamo, Magdalene Kuria, Esther Njiru, Mwangi Ngina, Penina Mwangi, Rachel Inginia, Melab Musabi, Emma Namulala, Grace Ochieng, Lydia Thuranira, Felicitas Makokha, Josephine Ojigo, Beth Maina, Catherine Mutinda, Mary Waiyego, Bernadette Lusweti, Angeline Ithondeka, Julie Barasa, Meshack Liru, Elizabeth Kibaru, Alice Nkirote Nyaribari, Joyce Akuka, Joyce Wangari, Amilia Ngoda, Aggrey Nzavaye Emenwa, Dolphine Mochache, Patricia Nafula Wesakania, George Lipesa, Jane Mbungu, Marystella Mutenyo, Joyce Mbogho, Joan Baswetty, Ann Jambi, Josephine Aritho, Beatrice Njambi, Felisters Mucheke, Zainab Kioni, Lucy Kinyua, Margaret Kethi, Alice Oguda, Salome Nashimiyu Situma, Nancy Gachaja, Loise N. Mwangi, Ruth Mwai, Irginia Wangari Muruga, Nancy Mburu, Celestine Muteshi, Abigael Bwire, Salome Okisa Muyale, Naomi Situma, Faith Mueni, Hellen Mwaura, Rosemary Mututa, Caroline Lavu, Joyce Oketch, Jane Hore Olum, Orina Nyakina, Faith Njeru, Rebecca Chelimo, Margaret Wanjiku Mwaura, Ann Wambugu, Epharus Njeri Mburu, Linda Awino Tindi, Jane Akumu, Ruth Otieno, Slessor Osok, Seline Kulubi, Susan Wanjala, Pauline Njeru, Rebbecca Mukami Mbogo, John Ollongo, Samuel Soita, Judith Mirenja, Mary Nguri, Margaret Waweru, Mary Akoth Oruko, Jeska Kuya, Caroline Muthuri, Esther Muthiani, Esther Mwangi, Joseph Nganga, Benjamin Tanui, Alfred Wanjau, Judith Onsongo, Peter Muigai, Arnest Namayi, Elizabeth Kosiom, Dorcas Cherop, Faith Marete, Johanness Simiyu, Collince Danga, Arthur Otieno Oyugi, Fredrick Keya Okoth, Jalemba Aluvaala

Homologous recombination deficiency (HRD) score in aggressive prostatic adenocarcinoma with or without intraductal carcinoma of the prostate (IDC-P)

Sha Zhu, Jinge Zhao, Ling Nie, Wenlian Yin, Yaowen Zhang, Fengnian Zhao, Yuchao Ni, Xingming Zhang, Zhipeng Wang, Jindong Dai, Zhenhua Liu, Junru Chen, Yuhao Zeng, Zilin Wang, Guangxi Sun, Jiayu Liang, Xiaochen Zhao, Xudong Zhu, Ronggui Tao, Jiyu Yang, Ben He, Ni Chen, Pengfei Shen, Hao Zeng

Weight loss-induced improvement of body weight and insulin sensitivity is not amplified by a subsequent 12-month weight maintenance intervention but is predicted by adaption of adipose atrial natriuretic peptide system: 48-month results of a randomized controlled trial

Linna Li, Dominik Soll, Verena Leupelt, Joachim Spranger, Knut Mai

Mammography screening is associated with more favourable breast cancer tumour characteristics and better overall survival: case-only analysis of 3739 Asian breast cancer patients

Zi Lin Lim, Peh Joo Ho, Alexis Jiaying Khng, Yen Shing Yeoh, Amanda Tse Woon Ong, Benita Kiat Tee Tan, Ern Yu Tan, Su-Ming Tan, Geok Hoon Lim, Jung Ah Lee, Veronique Kiak-Mien Tan, Jesse Hu, Jingmei Li, Mikael Hartman

Maternal smoking during pregnancy and type 1 diabetes in the offspring: a nationwide register-based study with family-based designs

Yuxia Wei, Tomas Andersson, Jessica Edstorp, Josefin E. Löfvenborg, Mats Talbäck, Maria Feychting, Sofia Carlsson

Helminth antigens differentially modulate the activation of CD4+ and CD8+ T lymphocytes of convalescent COVID-19 patients in vitro

Tomabu Adjobimey, Julia Meyer, Vedrana Terkeš, Marijo Parcina, Achim Hoerauf

Population-based plasma lipidomics reveals developmental changes in metabolism and signatures of obesity risk: a mother-offspring cohort study

Sartaj Ahmad Mir, Li Chen, Satvika Burugupalli, Bo Burla, Shanshan Ji, Adam Alexander T. Smith, Kothandaraman Narasimhan, Adaikalavan Ramasamy, Karen Mei-Ling Tan, Kevin Huynh, Corey Giles, Ding Mei, Gerard Wong, Fabian Yap, Kok Hian Tan, Fiona Collier, Richard Saffery, Peter Vuillermin, Anne K. Bendt, David Burgner, Anne-Louise Ponsonby, Yung Seng Lee, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Peter J. Meikle, Markus R. Wenk, Neerja Karnani

Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: a cohort study from OpenSAFELY

Amelia Green, Helen Curtis, William Hulme, Elizabeth Williamson, Helen McDonald, Krishnan Bhaskaran, Christopher Rentsch, Anna Schultze, Brian MacKenna, Viyaasan Mahalingasivam, Laurie Tomlinson, Alex Walker, Louis Fisher, Jon Massey, Colm Andrews, Lisa Hopcroft, Caroline Morton, Richard Croker, Jessica Morley, Amir Mehrkar, Seb Bacon, David Evans, Peter Inglesby, George Hickman, Tom Ward, Simon Davy, Rohini Mathur, John Tazare, Rosalind Eggo, Kevin Wing, Angel Wong, Harriet Forbes, Chris Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Ian Douglas, Stephen Evans, Liam Smeeth, Ben Goldacre

Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID)

Ekaterina Pazukhina, Margarita Andreeva, Ekaterina Spiridonova, Polina Bobkova, Anastasia Shikhaleva, Yasmin El-Taravi, Mikhail Rumyantsev, Aysylu Gamirova, Anastasiia Bairashevskaia, Polina Petrova, Dina Baimukhambetova, Maria Pikuza, Elina Abdeeva, Yulia Filippova, Salima Deunezhewa, Nikita Nekliudov, Polina Bugaeva, Nikolay Bulanov, Sergey Avdeev, Valentina Kapustina, Alla Guekht, Audrey DunnGalvin, Pasquale Comberiati, Diego G. Peroni, Christian Apfelbacher, Jon Genuneit, Luis Felipe Reyes, Caroline L. H. Brackel, Victor Fomin, Andrey A. Svistunov, Peter Timashev, Lyudmila Mazankova, Alexandra Miroshina, Elmira Samitova, Svetlana Borzakova, Elena Bondarenko, Anatoliy A. Korsunskiy, Gail Carson, Louise Sigfrid, Janet T. Scott, Matthew Greenhawt, Danilo Buonsenso, Malcolm G. Semple, John O. Warner, Piero Olliaro, Dale M. Needham, Petr Glybochko, Denis Butnaru, Ismail M. Osmanov, Daniel Munblit, Nikol Alekseeva, Elena Artigas, Asmik Avagyan, Lusine Baziyants, Anna Belkina, Anna Berbenyuk, Tatiana Bezbabicheva, Vadim Bezrukov, Semyon Bordyugov, Aleksandra Borisenko, Maria Bratukhina, Ekaterina Bugaiskaya, Julia Chayka, Yulia Cherdantseva, Natalia Degtyareva, Olesya Druzhkova, Alexander Dubinin, Khalisa Elifkhanova, Dmitry Eliseev, Anastasia Ezhova, Aleksandra Frolova, Julia Ganieva, Anastasia Gorina, Cyrill Gorlenko, Elizaveta Gribaleva, Eliza Gudratova, Shabnam Ibragimova, Khadizhat Kabieva, Yulia Kalan, Margarita Kalinina, Nadezhda Khitrina, Bogdan Kirillov, Herman Kiseljow, Maria Kislova, Natalya Kogut, Irina Konova, Mariia Korgunova, Anastasia Kotelnikova, Karina Kovygina, Alexandra Krupina, Anastasia Kuznetsova, Anna Kuznetsova, Baina Lavginova, Elza Lidjieva, Ekaterina Listovskaya, Maria Lobova, Maria Loshkareva, Ekaterina Lyubimova, Daria Mamchich, Nadezhda Markina, Anastasia Maystrenko, Aigun Mursalova, Evgeniy Nagornov, Anna Nartova, Daria Nikolaeva, Georgiy Novoselov, Marina Ogandzhanova, Anna Pavlenko, Olga Perekosova, Erika Porubayeva, Kristina Presnyakova, Anna Pushkareva, Olga Romanova, Philipp Roshchin, Diana Salakhova, Ilona Sarukhanyan, Victoria Savina, Jamilya Shatrova, Nataliya Shishkina, Anastasia Shvedova, Denis Smirnov, Veronika Solovieva, Olga Spasskaya, Olga Sukhodolskaya, Shakir Suleimanov, Nailya Urmantaeva, Olga Usalka, Valeria Ustyan, Yana Valieva, Katerina Varaksina, Maria Varaksina, Ekaterina Varlamova, Maria Vodianova, Margarita Yegiyan, Margarita Zaikina, Anastasia Zorina, Elena Zuykova

Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups

Marios K. Georgakis, Rainer Malik, Tom G. Richardson, Joanna M. M. Howson, Christopher D. Anderson, Stephen Burgess, G. Kees Hovingh, Martin Dichgans, Dipender Gill

The association between the pre-pregnancy vaginal microbiome and time-to-pregnancy: a Chinese pregnancy-planning cohort study

Xiang Hong, Jun Zhao, Jiechen Yin, Fanqi Zhao, Wei Wang, Xiaoling Ding, Hong Yu, Xu Ma, Bei Wang

The need for screening, early diagnosis, and prediction of chronic kidney disease in people with diabetes in low- and middle-income countries—a review of the current literature

Cindy George, Justin B. Echouffo-Tcheugui, Bernard G. Jaar, Ikechi G. Okpechi, Andre P. Kengne

Retraction Note: Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3β and mitochondrial function

Yingmei Zhang, Sara A. Babcock, Nan Hu, Jacalyn R. Maris, Haichang Wang, Jun Ren

Combined associations of family history and self-management with age at diagnosis and cardiometabolic risk in 86,931 patients with type 2 diabetes: Joint Asia Diabetes Evaluation (JADE) Register from 11 countries

Johnny T. K. Cheung, Eric Lau, Cyrus C. T. Tsui, Edmond L. N. Siu, Naomi K. W. Tse, Nicole Y. L. Hui, Ronald C. W. Ma, Alice P. S. Kong, Amy Fu, Vanessa Lau, Weiping Jia, Wayne H. H. Sheu, Leorino Sobrepena, K. H. Yoon, Alexander T. B. Tan, Yook-Chin Chia, Aravind Sosale, Banshi D. Saboo, Jothydev Kesavadev, Su-Yen Goh, Thy Khue Nguyen, Yotsapon Thewjitcharoen, Raymond Suwita, Andrea O. Y. Luk, Aimin Yang, Elaine Chow, Lee Ling Lim, Juliana C. N. Chan

Your height affects your health: genetic determinants and health-related outcomes in Taiwan

Jian-Shiun Chiou, Chi-Fung Cheng, Wen-Miin Liang, Chen-Hsing Chou, Chung-Hsing Wang, Wei-De Lin, Mu-Lin Chiu, Wei-Chung Cheng, Cheng-Wen Lin, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Chang-Hai Tsai, Ying-Ju Lin, Fuu-Jen Tsai

Medication use and risk of amyotrophic lateral sclerosis—a systematic review

Can Cui, Jiangwei Sun, Kyla A. McKay, Caroline Ingre, Fang Fang

Plasma metabolomic profiles of dementia: a prospective study of 110,655 participants in the UK Biobank

Xinyu Zhang, Wenyi Hu, Yueye Wang, Wei Wang, Huan Liao, Xiayin Zhang, Katerina V. Kiburg, Xianwen Shang, Gabriella Bulloch, Yu Huang, Xueli Zhang, Shulin Tang, Yijun Hu, Honghua Yu, Xiaohong Yang, Mingguang He, Zhuoting Zhu

Associations between gestational age and childhood sleep: a national retrospective cohort study

Jiajun Lyu, John A. Groeger, Anna L. Barnett, Haifeng Li, Lei Wang, Jiajia Zhang, Wenchong Du, Jing Hua

Practical guidance for planning resources required to support publicly-funded adaptive clinical trials

James M. S. Wason, Munyaradzi Dimairo, Katie Biggs, Sarah Bowden, Julia Brown, Laura Flight, Jamie Hall, Thomas Jaki, Rachel Lowe, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar, Christopher J. Weir, Nina Wilson, Christina Yap, Helen Hancock, Rebecca Maier

The lipidomic profile of the tumoral periprostatic adipose tissue reveals alterations in tumor cell’s metabolic crosstalk

Antonio Altuna-Coy, Xavier Ruiz-Plazas, Silvia Sánchez-Martin, Helena Ascaso-Til, Manuel Prados-Saavedra, Marta Alves-Santiago, Xana Bernal-Escoté, José Segarra-Tomás, Matilde R. Chacón

Increased blood-based intratumor heterogeneity (bITH) is associated with unfavorable outcomes of immune checkpoint inhibitors plus chemotherapy in non-small cell lung cancer

Juan Zhou, Minwei Bao, Guanghui Gao, Yiran Cai, Lihong Wu, Lei Lei, Jing Zhao, Xianxiu Ji, Ying Huang, Chunxia Su

Efficacy of SCF drug conjugate targeting c-KIT in gastrointestinal stromal tumor

Dengyang Zhang, Chunxiao He, Yao Guo, Jianfeng Li, Bo Li, Yuming Zhao, Liuting Yu, Zhiguang Chang, Hanzhong Pei, Ming Yang, Na Li, Qi Zhang, Yulong He, Yihang Pan, Zhizhuang Joe Zhao, Changhua Zhang, Yun Chen

A retrospective database study of the demographic features and glycemic control of patients with type 2 diabetes in Kinshasa, Democratic Republic of the Congo

Diana Sagastume, Elly Mertens, Deogratias Katsuva Sibongwere, Jean-Claude Dimbelolo, Jean Clovis Kalobu Kabundi, Jeroen de Man, Josefien Van Olmen, José L. Peñalvo

Tailoring cultural offers to meet the needs of older people during uncertain times: a rapid realist review

Stephanie Tierney, Sebastien Libert, Jordan Gorenberg, Geoff Wong, Amadea Turk, Kerryn Husk, Helen J. Chatterjee, Kathryn Eccles, Caroline Potter, Emma Webster, Beth McDougall, Harriet Warburton, Lucy Shaw, Nia Roberts, Kamal R. Mahtani

Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications

Ainhoa Bilbao, Rainer Spanagel

Association between CYP metabolizer phenotypes and selective serotonin reuptake inhibitors induced weight gain: a retrospective cohort study

Maria L. Ricardo-Silgado, Sneha Singh, Lizeth Cifuentes, Paul A. Decker, Daniel Gonzalez-Izundegui, Ann M. Moyer, Maria D. Hurtado, Michael Camilleri, Suzette J. Bielinski, Andres Acosta

Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study

Shanshan Wu, Changzheng Yuan, Zhirong Yang, Si Liu, Qian Zhang, Shutian Zhang, Shengtao Zhu

Modified cardiovascular SOFA score in sepsis: development and internal and external validation

Hui Jai Lee, Byuk Sung Ko, Seung Mok Ryoo, Eunah Han, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Tae Ho Lim, Won Young Kim, Woon Yong Kwon, Sung Yeon Hwang, You Hwan Jo, Jonghwan Shin, Tae Gun Shin, Kyuseok Kim, Sangchun Choi, Tae Nyoung Chung, Jae Hyuk Lee, Kyung Su Kim, Yoo Seok Park, Young-Hoon Yoon, Han Sung Choi, Kap Su Han, GuHyun Kang, Youn-Jung Kim, Hanjin Cho

Urinary symptoms and prostate cancer—the misconception that may be preventing earlier presentation and better survival outcomes

Vincent J. Gnanapragasam, David Greenberg, Neil Burnet

Correction: Systematic analysis of IL-6 as a predictive biomarker and desensitizer of immunotherapy responses in patients with non-small cell lung cancer

Chengming Liu, Lu Yang, Haiyan Xu, Sufei Zheng, Zhanyu Wang, Sihui Wang, Yaning Yang, Shuyang Zhang, Xiaoli Feng, Nan Sun, Yan Wang, Jie He

The accuracy of pulse oximetry in measuring oxygen saturation by levels of skin pigmentation: a systematic review and meta-analysis

Chunhu Shi, Mark Goodall, Jo Dumville, James Hill, Gill Norman, Oliver Hamer, Andrew Clegg, Caroline Leigh Watkins, George Georgiou, Alexander Hodkinson, Catherine Elizabeth Lightbody, Paul Dark, Nicky Cullum

Cellular transcriptional alterations of peripheral blood in Alzheimer’s disease

Liting Song, Yucheng T. Yang, Qihao Guo, Xing-Ming Zhao

Improving on-treatment risk stratification of cancer patients with refined response classification and integration of circulating tumor DNA kinetics

Jiawei Lv, Chenfei Wu, Junyan Li, Foping Chen, Shiwei He, Qingmei He, Guanqun Zhou, Jun Ma, Ying Sun, Denghui Wei, Li Lin

Deep learning radiomics of dual-modality ultrasound images for hierarchical diagnosis of unexplained cervical lymphadenopathy

Yangyang Zhu, Zheling Meng, Xiao Fan, Yin Duan, Yingying Jia, Tiantian Dong, Yanfang Wang, Juan Song, Jie Tian, Kun Wang, Fang Nie

Circulating exosomal mRNA signatures for the early diagnosis of clear cell renal cell carcinoma

Xing He, Feng Tian, Fei Guo, Fangxing Zhang, Huiyong Zhang, Jin Ji, Lin Zhao, Jingyi He, Yutian Xiao, Longman Li, Chunmeng Wei, Caihong Huang, Yexin Li, Feng Zhang, Bo Yang, Huamao Ye, Fubo Wang

Regular proton pump inhibitor use and incident dementia: population-based cohort study

Peidong Zhang, Zhihao Li, Peiliang Chen, Ao Zhang, Yu Zeng, Xiru Zhang, Qingmei Huang, Dan Liu, Songtao Qi, Chen Mao

l-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study

Jie V. Zhao, Stephen Burgess, Bohan Fan, C. Mary Schooling

Associations between consumption of three types of beverages and risk of cardiometabolic multimorbidity in UK Biobank participants: a prospective cohort study

Yi Luo, Lingfang He, Tianqi Ma, Jinchen Li, Yongping Bai, Xunjie Cheng, Guogang Zhang

Frailty in individuals with depression, bipolar disorder and anxiety disorders: longitudinal analyses of all-cause mortality

Julian Mutz, Umamah Choudhury, Jinlong Zhao, Alexandru Dregan

Risk of hip fracture in meat-eaters, pescatarians, and vegetarians: results from the UK Women’s Cohort Study

James Webster, Darren C. Greenwood, Janet E. Cade

Pyrotinib combined with apatinib for targeting metastatic non-small cell lung cancer with HER2 alterations: a prospective, open-label, single-arm phase 2 study (PATHER2)

Guangjian Yang, Haiyan Xu, Yaning Yang, Shuyang Zhang, Fei Xu, Xuezhi Hao, Junling Li, Puyuan Xing, Xingsheng Hu, Yutao Liu, Lin Wang, Lin Lin, Zhijie Wang, Jianchun Duan, Jie Wang, Yan Wang

Medium- and longer-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial

Markos Klonizakis, Anil Gumber, Emma McIntosh, Leonie S. Brose

Age and product dependent vaccine effectiveness against SARS-CoV-2 infection and hospitalisation among adults in Norway: a national cohort study, July–November 2021

Jostein Starrfelt, Anders Skyrud Danielsen, Eirik Alnes Buanes, Lene Kristine Juvet, Trude Marie Lyngstad, Gunnar Øyvind Isaksson Rø, Lamprini Veneti, Sara Viksmoen Watle, Hinta Meijerink

Occult infection with hepatitis B virus PreS variants synergistically promotes hepatocellular carcinoma development in a high-fat diet context by generating abnormal ceramides

Chang Liu, Kun Chen, Fei Zhao, Lingling Xuan, Yuting Wang, Chungui Xu, Zhiyuan Wu, Dongmei Wang, Chunfeng Qu

Severe acute hepatitis of unknown aetiology in children—what is known?

Susan Khader, Isabel Foster, Andrew Dagens, Alice Norton, Louise Sigfrid

Correction: Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study

Junyi Xin, Xia Jiang, Shuai Ben, Qianyu Yuan, Li Su, Zhengdong Zhang, David C. Christiani, Mulong Du, Meilin Wang

Effect of sorafenib maintenance on Epstein-Barr virus and cytomegalovirus infections in patients with FLT3-ITD AML undergoing allogeneic hematopoietic stem cell transplantation: a secondary analysis of a randomized clinical trial

Xin Xu, Zhiping Fan, Yu Wang, Fen Huang, Yajing Xu, Jing Sun, Na Xu, Lan Deng, Xudong Li, Xinquan Liang, Xiaodan Luo, Pengcheng Shi, Hui Liu, Yan Chen, Sanfang Tu, Xiaojun Huang, Qifa Liu, Li Xuan

Dissection of transcriptome dysregulation and immune characterization in women with germline BRCA1 mutation at single-cell resolution

Xuexin Yu, Wanrun Lin, Alexandra Spirtos, Yan Wang, Hao Chen, Jianfeng Ye, Jessica Parker, Ci Ci Liu, Yiying Wang, Gabriella Quinn, Feng Zhou, Setsuko K. Chambers, Cheryl Lewis, Jayanthi Lea, Bo Li, Wenxin Zheng

Clinical translation of stem cell therapy for spinal cord injury still premature: results from a single-arm meta-analysis based on 62 clinical trials

Zhizhong Shang, Mingchuan Wang, Baolin Zhang, Xin Wang, Pingping Wanyan

Correction: The UK Coronavirus Job Retention Scheme and diet, physical activity, and sleep during the COVID-19 pandemic: evidence from eight longitudinal population surveys

Bożena Wielgoszewska, Jane Maddock, Michael J. Green, Giorgio Di Gessa, Sam Parsons, Gareth J. Griffith, Jazz Croft, Anna J. Stevenson, Charlotte Booth, Richard J. Silverwood, David Bann, Praveetha Patalay, Alun D. Hughes, Nishi Chaturvedi, Laura D. Howe, Emla Fitzsimons, Srinivasa Vittal Katikireddi, George B. Ploubidis

Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank

Rongtao Jiang, Margaret L. Westwater, Stephanie Noble, Matthew Rosenblatt, Wei Dai, Shile Qi, Jing Sui, Vince D. Calhoun, Dustin Scheinost

Diet and irritable bowel syndrome: an update from a UK consensus meeting

A. Rej, A. Avery, I. Aziz, C. J. Black, R. K. Bowyer, R. L. Buckle, L. Seamark, C. C. Shaw, J. Thompson, N. Trott, M. Williams, D. S. Sanders

Safety of beta-blocker and calcium channel blocker antihypertensive drugs in pregnancy: a Mendelian randomization study

Maddalena Ardissino, Eric A. W. Slob, Skanda Rajasundaram, Rohin K. Reddy, Benjamin Woolf, Joanna Girling, Mark R. Johnson, Fu Siong Ng, Dipender Gill

Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children

Gaoqian Feng, Liriye Kurtovic, Paul A. Agius, Elizabeth H. Aitken, Jahit Sacarlal, Bruce D. Wines, P. Mark Hogarth, Stephen J. Rogerson, Freya J. I. Fowkes, Carlota Dobaño, James G. Beeson

Device-measured physical activity and incident affective disorders

Frederick K. Ho, Fanny Petermann-Rocha, Solange Parra-Soto, Jirapitcha Boonpor, Jason M. R. Gill, Stuart R. Gray, Jill P. Pell, Carlos Celis-Morales

Prevalence of microcephaly and Zika virus infection in a pregnancy cohort in Kenya, 2017–2019

Eric Osoro, Irene Inwani, Cyrus Mugo, Elizabeth Hunsperger, Jennifer R. Verani, Victor Omballa, Dalton Wamalwa, Chulwoo Rhee, Ruth Nduati, John Kinuthia, Hafsa Jin, Lydia Okutoyi, Dufton Mwaengo, Brian Maugo, Nancy A. Otieno, Harriet Mirieri, Mufida Shabibi, Peninah Munyua, M. Kariuki Njenga, Marc-Alain Widdowson

High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth

Zhihua Wang, Miaomiao Wang, Mengxin Zhang, Kaikun Xu, Xinshuai Zhang, Yi Xie, Yiming Zhang, Cheng Chang, Xiaolu Li, Aihua Sun, Fuchu He

The prevalence of onchocerciasis in Africa and Yemen, 2000–2018: a geospatial analysis

Chris A. Schmidt, Elizabeth A. Cromwell, Elex Hill, Katie M. Donkers, Megan F. Schipp, Kimberly B. Johnson, David M. Pigott, Chris A. Schmidt, Elizabeth A. Cromwell, Elex Hill, David M. Pigott, Jaffar Abbas, Victor Adekanmbi, Olatunji O. Adetokunboh, Muktar Beshir Ahmed, Fahad Mashhour Alanezi, Turki M. Alanzi, Vahid Alipour, Catalina Liliana Andrei, Tudorel Andrei, Davood Anvari, Seth Christopher Yaw Appiah, Muhammad Aqeel, Jalal Arabloo, Mohammad Asghari Jafarabadi, Marcel Ausloos, Atif Amin Baig, Maciej Banach, Till Winfried Bärnighausen, Krittika Bhattacharyya, Zulfiqar A. Bhutta, Ali Bijani, Oliver J. Brady, Nicola Luigi Bragazzi, Zahid A. Butt, Felix Carvalho, Vijay Kumar Chattu, Saad M. A. Dahlawi, Giovanni Damiani, Feleke Mekonnen Demeke, Kebede Deribe, Samath Dhamminda Dharmaratne, Daniel Diaz, Alireza Didarloo, Lucas Earl, Maysaa El Sayed Zaki, Maha El Tantawi, Nazir Fattahi, Eduarda Fernandes, Nataliya A. Foigt, Masoud Foroutan, Richard Charles Franklin, Yuming Guo, Arvin Haj-Mirzaian, Samer Hamidi, Hadi Hassankhani, Claudiu Herteliu, Tarig B. Higazi, Mostafa Hosseini, Mehdi Hosseinzadeh, Mowafa Househ, Olayinka Stephen Ilesanmi, Irena M. Ilic, Milena D. Ilic, Seyed Sina Naghibi Irvani, Ravi Prakash Jha, John S. Ji, Jost B. Jonas, Jacek Jerzy Jozwiak, Leila R. Kalankesh, Naser Kamyari, Behzad Karami Matin, Salah Eddin Karimi, Gbenga A. Kayode, Ali Kazemi Karyani, Ejaz Ahmad Khan, Md Nuruzzaman Khan, Khaled Khatab, Mona M. Khater, Neda Kianipour, Yun Jin Kim, Soewarta Kosen, Dian Kusuma, Carlo La Vecchia, Van Charles Lansingh, Paul H. Lee, Shanshan Li, Shokofeh Maleki, Mohammad Ali Mansournia, Francisco Rogerlândio Martins-Melo, Colm McAlinden, Walter Mendoza, Tomislav Mestrovic, Masoud Moghadaszadeh, Abdollah Mohammadian-Hafshejani, Seyyede Momeneh Mohammadi, Shafiu Mohammed, Rahmatollah Moradzadeh, Paula Moraga, Mehdi Naderi, Ahamarshan Jayaraman Nagarajan, Ionut Negoi, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Bogdan Oancea, Andrew T. Olagunju, Ahmed Omar Bali, Obinna E. Onwujekwe, Adrian Pana, Vafa Rahimi-Movaghar, Kiana Ramezanzadeh, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Aziz Rezapour, Ana Isabel Ribeiro, Abdallah M. Samy, Masood Ali Shaikh, Kiomars Sharafi, Aziz Sheikh, Jasvinder A. Singh, Eirini Skiadaresi, Shahin Soltani, Wilma A. Stolk, Mu’awiyyah Babale Sufiyan, Alan J. Thomson, Bach Xuan Tran, Khanh Bao Tran, Bhaskaran Unnikrishnan, Francesco S. Violante, Giang Thu Vu, Tomohide Yamada, Sanni Yaya, Paul Yip, Naohiro Yonemoto, Chuanhua Yu, Yong Yu, Maryam Zamanian, Yunquan Zhang, Zhi-Jiang Zhang, Arash Ziapour, Simon I. Hay, Simon I. Hay

Twenty-year trends in racial and ethnic enrollment in large diabetes randomized controlled trials

Jingyi Zhang, Harriette G. C. Van Spall, Yaoyao Wang, Lehana Thabane, Ruoting Wang, Guowei Li

Investigating causal relations between sleep duration and risks of adverse pregnancy and perinatal outcomes: linear and nonlinear Mendelian randomization analyses

Qian Yang, Maria C. Magnus, Fanny Kilpi, Gillian Santorelli, Ana Gonçalves Soares, Jane West, Per Magnus, John Wright, Siri Eldevik Håberg, Eleanor Sanderson, Deborah A. Lawlor, Kate Tilling, Maria Carolina Borges

Maternal smoking during pregnancy and health outcomes in offspring

Hongjiang Wu, Andrea O. Y. Luk

Optimising a person-centred approach to stopping medicines in older people with multimorbidity and polypharmacy using the DExTruS framework: a realist review

Amadea Turk, Geoffrey Wong, Kamal R. Mahtani, Michelle Maden, Ruaraidh Hill, Ed Ranson, Emma Wallace, Janet Krska, Dee Mangin, Richard Byng, Daniel Lasserson, Joanne Reeve

Polycystic ovary syndrome and risk of adverse obstetric outcomes: a retrospective population-based matched cohort study in England

Anuradhaa Subramanian, Siang Ing Lee, Katherine Phillips, Konstantinos A. Toulis, Punith Kempegowda, Michael W. O’Reilly, Nicola J. Adderley, Shakila Thangaratinam, Wiebke Arlt, Krishnarajah Nirantharakumar

Cardiovascular health in the menopause transition: a longitudinal study of up to 3892 women with up to four repeated measures of risk factors

Gemma L. Clayton, Ana Gonçalves Soares, Fanny Kilpi, Abigail Fraser, Paul Welsh, Naveed Sattar, Scott M. Nelson, Kate Tilling, Deborah A. Lawlor

Genetic evidence for a causal relationship between type 2 diabetes and peripheral artery disease in both Europeans and East Asians

Xuehao Xiu, Haoyang Zhang, Angli Xue, David N. Cooper, Li Yan, Yuedong Yang, Yuanhao Yang, Huiying Zhao

C-reactive protein and cancer risk: a pan-cancer study of prospective cohort and Mendelian randomization analysis

Meng Zhu, Zhimin Ma, Xu Zhang, Dong Hang, Rong Yin, Jifeng Feng, Lin Xu, Hongbing Shen

External validation of models for predicting risk of colorectal cancer using the China Kadoorie Biobank

Roxanna E. Abhari, Blake Thomson, Ling Yang, Iona Millwood, Yu Guo, Xiaoming Yang, Jun Lv, Daniel Avery, Pei Pei, Peng Wen, Canqing Yu, Yiping Chen, Junshi Chen, Liming Li, Zhengming Chen, Christiana Kartsonaki

A blood-based miRNA signature for early non-invasive diagnosis of preeclampsia

Siqi Bao, Tong Zhou, Congcong Yan, Jiale Bao, Fan Yang, Shan Chao, Meng Zhou, Zhangye Xu

Sex-specific patterns and lifetime risk of multimorbidity in the general population: a 23-year prospective cohort study

Premysl Velek, Annemarie I. Luik, Guy G. O. Brusselle, Bruno Ch. Stricker, Patrick J. E. Bindels, Maryam Kavousi, Brenda C. T. Kieboom, Trudy Voortman, Rikje Ruiter, M. Arfan Ikram, M. Kamran Ikram, Evelien I. T. de Schepper, Silvan Licher

Development and validation of prediction models for gestational diabetes treatment modality using supervised machine learning: a population-based cohort study

Lauren D. Liao, Assiamira Ferrara, Mara B. Greenberg, Amanda L. Ngo, Juanran Feng, Zhenhua Zhang, Patrick T. Bradshaw, Alan E. Hubbard, Yeyi Zhu

Trends in psychotropic drug consumption among French military personnel during the COVID-19 epidemic

Marc-Antoine Sanchez, Basile Fuchs, Pascale Tubert-Bitter, Anne-Sophie Mariet, Fabrice Jollant, Aurélie Mayet, Catherine Quantin

Prevention and control of non-communicable diseases in antenatal, intrapartum, and postnatal care: a systematic scoping review of clinical practice guidelines since 2011

Jenny Jung, Eshreena K. Karwal, Steve McDonald, Tari Turner, Doris Chou, Joshua P. Vogel

L-shaped association of serum 25-hydroxyvitamin D concentrations with cardiovascular and all-cause mortality in individuals with osteoarthritis: results from the NHANES database prospective cohort study

Qingqing Xiao, Bin Cai, Anwen Yin, Huanhuan Huo, Keke Lan, Guo Zhou, Linghong Shen, Ben He

Dapagliflozin attenuates diabetes-induced diastolic dysfunction and cardiac fibrosis by regulating SGK1 signaling

Seul-Gee Lee, Darae Kim, Jung-Jae Lee, Hyun-Ju Lee, Ro-kyung Moon, Yong-Joon Lee, Seung-Jun Lee, Oh-Hyun Lee, Choongki Kim, Jaewon Oh, Chan Joo Lee, Yong-ho Lee, Seil Park, Ok-Hee Jeon, Donghoon Choi, Geu-Ru Hong, Jung-Sun Kim

Effectiveness of a digital medication event reminder and monitor device for patients with tuberculosis (SELFTB): a multicenter randomized controlled trial

Tsegahun Manyazewal, Yimtubezinash Woldeamanuel, David P. Holland, Abebaw Fekadu, Vincent C. Marconi

Sex and macroeconomic differences and trends in early attempts at cigarette smoking among adolescents: findings from 147 countries

Huaqing Liu, Qi Qi, Ying Duan, Chuanwei Ma, Chengchao Zhou

Vaccine effectiveness against referral to hospital after SARS-CoV-2 infection in St. Petersburg, Russia, during the Delta variant surge: a test-negative case-control study

Anton Barchuk, Mikhail Cherkashin, Anna Bulina, Natalia Berezina, Tatyana Rakova, Darya Kuplevatskaya, Oksana Stanevich, Dmitriy Skougarevskiy, Artemiy Okhotin

Longitudinal patterns and predictors of healthcare utilization among cancer patients on home-based palliative care in Singapore: a group-based multi-trajectory analysis

Qingyuan Zhuang, Poh-Heng Chong, Whee Sze Ong, Zhi Zheng Yeo, Cherylyn Qun Zhen Foo, Su Yan Yap, Guozhang Lee, Grace Meijuan Yang, Sungwon Yoon

Genetic predispositions to psychiatric disorders and the risk of COVID-19

Wenwen Chen, Yu Zeng, Chen Suo, Huazhen Yang, Yilong Chen, Can Hou, Yao Hu, Zhiye Ying, Yajing Sun, Yuanyuan Qu, Donghao Lu, Fang Fang, Unnur A. Valdimarsdóttir, Huan Song

Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis

Andrew J. Shih, Robert P. Adelson, Himanshu Vashistha, Houman Khalili, Ashima Nayyar, Radha Puran, Rixsi Herrera, Prodyot K. Chatterjee, Annette T. Lee, Alexander M. Truskinovsky, Kristine Elmaliki, Margaret DeFranco, Christine N. Metz, Peter K. Gregersen

Single nucleotide polymorphism genes and mitochondrial DNA haplogroups as biomarkers for early prediction of knee osteoarthritis structural progressors: use of supervised machine learning classifiers

Hossein Bonakdari, Jean-Pierre Pelletier, Francisco J. Blanco, Ignacio Rego-Pérez, Alejandro Durán-Sotuela, Dawn Aitken, Graeme Jones, Flavia Cicuttini, Afshin Jamshidi, François Abram, Johanne Martel-Pelletier

A cost-effectiveness analysis of capecitabine maintenance therapy versus routine follow-up for early-stage triple-negative breast cancer patients after standard treatment from a perspective of Chinese society

Ji-Bin Li, Zhuo-Chen Lin, Martin C. S. Wong, Harry H. X. Wang, Mengmeng Li, Su Li

Imaging-based body fat depots and new-onset atrial fibrillation in general population: a prospective cohort study

Zuolin Lu, Martijn J. Tilly, Elif Aribas, Daniel Bos, Sven Geurts, Bruno H. Stricker, Robert de Knegt, M. Arfan Ikram, Natasja M. S. de Groot, Trudy Voortman, Maryam Kavousi

High prevalence and significant ethnic differences in actionable HbA1C after gestational diabetes mellitus in women living in Norway

Archana Sharma, Ingrid Nermoen, Elisabeth Qvigstad, Anh T. Tran, Christine Sommer, Naveed Sattar, Jason M. R. Gill, Hanne L. Gulseth, Stina T. Sollid, Kåre I. Birkeland

The influence of mode of anaesthesia on perioperative outcomes in people with hip fracture: a prospective cohort study from the National Hip Fracture Database for England, Wales and Northern Ireland

Gulraj S. Matharu, Anjali Shah, Samuel Hawley, Antony Johansen, Dominic Inman, Iain Moppett, Michael R. Whitehouse, Andrew Judge

A phase Ib study of camrelizumab in combination with apatinib and fuzuloparib in patients with recurrent or metastatic triple-negative breast cancer

Qingyuan Zhang, Bin Shao, Zhongsheng Tong, Quchang Ouyang, Yuting Wang, Guoying Xu, Shaorong Li, Huiping Li

Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt, Laurence Baril

Short-chain fatty acid concentrations in the incidence and risk-stratification of colorectal cancer: a systematic review and meta-analysis

Ehsan Alvandi, Wilson K. M. Wong, Mugdha V. Joglekar, Kevin J. Spring, Anandwardhan A. Hardikar

Development and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients

Flávio de Azevedo Figueiredo, Lucas Emanuel Ferreira Ramos, Rafael Tavares Silva, Daniela Ponce, Rafael Lima Rodrigues de Carvalho, Alexandre Vargas Schwarzbold, Amanda de Oliveira Maurílio, Ana Luiza Bahia Alves Scotton, Andresa Fontoura Garbini, Bárbara Lopes Farace, Bárbara Machado Garcia, Carla Thais Cândida Alves da Silva, Christiane Corrêa Rodrigues Cimini, Cíntia Alcantara de Carvalho, Cristiane dos Santos Dias, Daniel Vitório Silveira, Euler Roberto Fernandes Manenti, Evelin Paola de Almeida Cenci, Fernando Anschau, Fernando Graça Aranha, Filipe Carrilho de Aguiar, Frederico Bartolazzi, Giovanna Grunewald Vietta, Guilherme Fagundes Nascimento, Helena Carolina Noal, Helena Duani, Heloisa Reniers Vianna, Henrique Cerqueira Guimarães, Joice Coutinho de Alvarenga, José Miguel Chatkin, Júlia Drumond Parreiras de Morais, Juliana Machado-Rugolo, Karen Brasil Ruschel, Karina Paula Medeiros Prado Martins, Luanna Silva Monteiro Menezes, Luciana Siuves Ferreira Couto, Luís César de Castro, Luiz Antônio Nasi, Máderson Alvares de Souza Cabral, Maiara Anschau Floriani, Maíra Dias Souza, Maira Viana Rego Souza-Silva, Marcelo Carneiro, Mariana Frizzo de Godoy, Maria Aparecida Camargos Bicalho, Maria Clara Pontello Barbosa Lima, Márlon Juliano Romero Aliberti, Matheus Carvalho Alves Nogueira, Matheus Fernandes Lopes Martins, Milton Henriques Guimarães-Júnior, Natália da Cunha Severino Sampaio, Neimy Ramos de Oliveira, Patricia Klarmann Ziegelmann, Pedro Guido Soares Andrade, Pedro Ledic Assaf, Petrônio José de Lima Martelli, Polianna Delfino-Pereira, Raphael Castro Martins, Rochele Mosmann Menezes, Saionara Cristina Francisco, Silvia Ferreira Araújo, Talita Fischer Oliveira, Thainara Conceição de Oliveira, Thaís Lorenna Souza Sales, Thiago Junqueira Avelino-Silva, Yuri Carlotto Ramires, Magda Carvalho Pires, Milena Soriano Marcolino

Face-to-face physical activity incorporated into dietary intervention for overweight/obesity in children and adolescents: a Bayesian network meta-analysis

Jing Hong Liang, Yu Zhao, Yi Can Chen, Nan Jiang, Shu Xin Zhang, Shan Huang, Aerziguli Kakaer, Ya Jun Chen

Clinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry

Giulio Francesco Romiti, Marco Proietti, Marco Vitolo, Niccolò Bonini, Ameenathul Mazaya Fawzy, Wern Yew Ding, Laurent Fauchier, Francisco Marin, Michael Nabauer, Gheorghe Andrei Dan, Tatjana S. Potpara, Giuseppe Boriani, Gregory Y. H. Lip, L. Tavazzi, A. P. Maggioni, Z. Kalarus, R. Ferrari, A. Shantsila, A. Goda, G. Mairesse, T. Shalganov, L. Antoniades, M. Taborsky, S. Riahi, P. Muda, I. García Bolao, O. Piot, K. Etsadashvili, E. N. Simantirakis, M. Haim, A. Azhari, J. Najafian, M. Santini, E. Mirrakhimov, K. Kulzida, A. Erglis, L. Poposka, M. R. Burg, H. Crijns, Ö. Erküner, D. Atar, R. Lenarczyk, M. Martins Oliveira, D. Shah, E. Serdechnaya, E. Diker, D. Lane, E. Zëra, U. Ekmekçiu, V. Paparisto, M. Tase, H. Gjergo, J. Dragoti, A. Goda, M. Ciutea, N. Ahadi, Z. el Husseini, M. Raepers, J. Leroy, P. Haushan, A. Jourdan, C. Lepiece, L. Desteghe, J. Vijgen, P. Koopman, G. Van Genechten, H. Heidbuchel, T. Boussy, M. De Coninck, H. Van Eeckhoutte, N. Bouckaert, A. Friart, J. Boreux, C. Arend, P. Evrard, L. Stefan, E. Hoffer, J. Herzet, M. Massoz, C. Celentano, M. Sprynger, L. Pierard, P. Melon, B. Van Hauwaert, C. Kuppens, D. Faes, D. Van Lier, A. Van Dorpe, A. Gerardy, O. Deceuninck, O. Xhaet, F. Dormal, E. Ballant, D. Blommaert, D. Yakova, M. Hristov, T. Yncheva, N. Stancheva, S. Tisheva, M. Tokmakova, F. Nikolov, D. Gencheva, T. Shalganov, B. Kunev, M. Stoyanov, D. Marchov, V. Gelev, V. Traykov, A. Kisheva, H. Tsvyatkov, R. Shtereva, S. Bakalska-Georgieva, S. Slavcheva, Y. Yotov, M. Kubíčková, A. Marni Joensen, A. Gammelmark, L. Hvilsted Rasmussen, P. Dinesen, S. Riahi, S. Krogh Venø, B. Sorensen, A. Korsgaard, K. Andersen, C. Fragtrup Hellum, A. Svenningsen, O. Nyvad, P. Wiggers, O. May, A. Aarup, B. Graversen, L. Jensen, M. Andersen, M. Svejgaard, S. Vester, S. Hansen, V. Lynggaard, M. Ciudad, R. Vettus, P. Muda, A. Maestre, S. Castaño, S. Cheggour, J. Poulard, V. Mouquet, S. Leparrée, J. Bouet, J. Taieb, A. Doucy, H. Duquenne, A. Furber, J. Dupuis, J. Rautureau, M. Font, P. Damiano, M. Lacrimini, J. Abalea, S. Boismal, T. Menez, J. Mansourati, G. Range, H. Gorka, C. Laure, C. Vassalière, N. Elbaz, N. Lellouche, K. Djouadi, F. Roubille, D. Dietz, J. Davy, M. Granier, P. Winum, C. Leperchois-Jacquey, H. Kassim, E. Marijon, J. Le Heuzey, J. Fedida, C. Maupain, C. Himbert, E. Gandjbakhch, F. Hidden-Lucet, G. Duthoit, N. Badenco, T. Chastre, X. Waintraub, M. Oudihat, J. Lacoste, C. Stephan, H. Bader, N. Delarche, L. Giry, D. Arnaud, C. Lopez, F. Boury, I. Brunello, M. Lefèvre, R. Mingam, M. Haissaguerre, M. Le Bidan, D. Pavin, V. Le Moal, C. Leclercq, O. Piot, T. Beitar, I. Martel, A. Schmid, N. Sadki, C. Romeyer-Bouchard, A. Da Costa, I. Arnault, M. Boyer, C. Piat, N. Lozance, S. Nastevska, A. Doneva, B. Fortomaroska Milevska, B. Sheshoski, K. Petroska, N. Taneska, N. Bakrecheski, K. Lazarovska, S. Jovevska, V. Ristovski, A. Antovski, E. Lazarova, I. Kotlar, J. Taleski, L. Poposka, S. Kedev, N. Zlatanovik, S. Jordanova, T. Bajraktarova Proseva, S. Doncovska, D. Maisuradze, A. Esakia, E. Sagirashvili, K. Lartsuliani, N. Natelashvili, N. Gumberidze, R. Gvenetadze, K. Etsadashvili, N. Gotonelia, N. Kuridze, G. Papiashvili, I. Menabde, S. Glöggler, A. Napp, C. Lebherz, H. Romero, K. Schmitz, M. Berger, M. Zink, S. Köster, J. Sachse, E. Vonderhagen, G. Soiron, K. Mischke, R. Reith, M. Schneider, W. Rieker, D. Boscher, A. Taschareck, A. Beer, D. Oster, O. Ritter, J. Adamczewski, S. Walter, A. Frommhold, E. Luckner, J. Richter, M. Schellner, S. Landgraf, S. Bartholome, R. Naumann, J. Schoeler, D. Westermeier, F. William, K. Wilhelm, M. Maerkl, R. Oekinghaus, M. Denart, M. Kriete, U. Tebbe, T. Scheibner, M. Gruber, A. Gerlach, C. Beckendorf, L. Anneken, M. Arnold, S. Lengerer, Z. Bal, C. Uecker, H. Förtsch, S. Fechner, V. Mages, E. Martens, H. Methe, T. Schmidt, B. Schaeffer, B. Hoffmann, J. Moser, K. Heitmann, S. Willems, S. Willems, C. Klaus, I. Lange, M. Durak, E. Esen, F. Mibach, H. Mibach, A. Utech, M. Gabelmann, R. Stumm, V. Ländle, C. Gartner, C. Goerg, N. Kaul, S. Messer, D. Burkhardt, C. Sander, R. Orthen, S. Kaes, A. Baumer, F. Dodos, A. Barth, G. Schaeffer, J. Gaertner, J. Winkler, A. Fahrig, J. Aring, I. Wenzel, S. Steiner, A. Kliesch, E. Kratz, K. Winter, P. Schneider, A. Haag, I. Mutscher, R. Bosch, J. Taggeselle, S. Meixner, A. Schnabel, A. Shamalla, H. Hötz, A. Korinth, C. Rheinert, G. Mehltretter, B. Schön, N. Schön, A. Starflinger, E. Englmann, G. Baytok, T. Laschinger, G. Ritscher, A. Gerth, D. Dechering, L. Eckardt, M. Kuhlmann, N. Proskynitopoulos, J. Brunn, K. Foth, C. Axthelm, H. Hohensee, K. Eberhard, S. Turbanisch, N. Hassler, A. Koestler, G. Stenzel, D. Kschiwan, M. Schwefer, S. Neiner, S. Hettwer, M. Haeussler-Schuchardt, R. Degenhardt, S. Sennhenn, S. Steiner, M. Brendel, A. Stoehr, W. Widjaja, S. Loehndorf, A. Logemann, J. Hoskamp, J. Grundt, M. Block, R. Ulrych, A. Reithmeier, V. Panagopoulos, C. Martignani, D. Bernucci, E. Fantecchi, I. Diemberger, M. Ziacchi, M. Biffi, P. Cimaglia, J. Frisoni, I. Giannini, S. Boni, S. Fumagalli, S. Pupo, A. Di Chiara, P. Mirone, E. Fantecchi, F. Pesce, C. Zoccali, V. L. Malavasi, A. Mussagaliyeva, B. Ahyt, Z. Salihova, K. Koshum-Bayeva, A. Kerimkulova, A. Bairamukova, E. Mirrakhimov, B. Lurina, R. Zuzans, S. Jegere, I. Mintale, K. Kupics, K. Jubele, A. Erglis, O. Kalejs, K. Vanhear, M. Burg, M. Cachia, E. Abela, S. Warwicker, T. Tabone, R. Xuereb, D. Asanovic, D. Drakalovic, M. Vukmirovic, N. Pavlovic, L. Music, N. Bulatovic, A. Boskovic, H. Uiterwaal, N. Bijsterveld, J. De Groot, J. Neefs, N. van den Berg, F. Piersma, A. Wilde, V. Hagens, J. Van Es, J. Van Opstal, B. Van Rennes, H. Verheij, W. Breukers, G. Tjeerdsma, R. Nijmeijer, D. Wegink, R. Binnema, S. Said, Ö. Erküner, S. Philippens, W. van Doorn, H. Crijns, T. Szili-Torok, R. Bhagwandien, P. Janse, A. Muskens, M. van Eck, R. Gevers, N. van der Ven, A. Duygun, B. Rahel, J. Meeder, A. Vold, C. Holst Hansen, I. Engset, D. Atar, B. Dyduch-Fejklowicz, E. Koba, M. Cichocka, A. Sokal, A. Kubicius, E. Pruchniewicz, A. Kowalik-Sztylc, W. Czapla, I. Mróz, M. Kozlowski, T. Pawlowski, M. Tendera, A. Winiarska-Filipek, A. Fidyk, A. Slowikowski, M. Haberka, M. Lachor-Broda, M. Biedron, Z. Gasior, M. Kołodziej, M. Janion, I. Gorczyca-Michta, B. Wozakowska-Kaplon, M. Stasiak, P. Jakubowski, T. Ciurus, J. Drozdz, M. Simiera, P. Zajac, T. Wcislo, P. Zycinski, J. Kasprzak, A. Olejnik, E. Harc-Dyl, J. Miarka, M. Pasieka, M. Ziemińska-Łuć, W. Bujak, A. Śliwiński, A. Grech, J. Morka, K. Petrykowska, M. Prasał, G. Hordyński, P. Feusette, P. Lipski, A. Wester, W. Streb, J. Romanek, P. Woźniak, M. Chlebuś, P. Szafarz, W. Stanik, M. Zakrzewski, J. Kaźmierczak, A. Przybylska, E. Skorek, H. Błaszczyk, M. Stępień, S. Szabowski, W. Krysiak, M. Szymańska, J. Karasiński, J. Blicharz, M. Skura, K. Hałas, L. Michalczyk, Z. Orski, K. Krzyżanowski, A. Skrobowski, L. Zieliński, M. Tomaszewska-Kiecana, M. Dłużniewski, M. Kiliszek, M. Peller, M. Budnik, P. Balsam, G. Opolski, A. Tymińska, K. Ozierański, A. Wancerz, A. Borowiec, E. Majos, R. Dabrowski, H. Szwed, A. Musialik-Lydka, A. Leopold-Jadczyk, E. Jedrzejczyk-Patej, M. Koziel, R. Lenarczyk, M. Mazurek, Z. Kalarus, K. Krzemien-Wolska, P. Starosta, E. Nowalany-Kozielska, A. Orzechowska, M. Szpot, M. Staszel, S. Almeida, H. Pereira, L. Brandão Alves, R. Miranda, L. Ribeiro, F. Costa, F. Morgado, P. Carmo, P. Galvao Santos, R. Bernardo, P. Adragão, G. Ferreira da Silva, M. Peres, M. Alves, M. Leal, A. Cordeiro, P. Magalhães, P. Fontes, S. Leão, A. Delgado, A. Costa, B. Marmelo, B. Rodrigues, D. Moreira, J. Santos, L. Santos, A. Terchet, D. Darabantiu, S. Mercea, V. Turcin Halka, A. Pop Moldovan, A. Gabor, B. Doka, G. Catanescu, H. Rus, L. Oboroceanu, E. Bobescu, R. Popescu, A. Dan, A. Buzea, I. Daha, G. Dan, I. Neuhoff, M. Baluta, R. Ploesteanu, N. Dumitrache, M. Vintila, A. Daraban, C. Japie, E. Badila, H. Tewelde, M. Hostiuc, S. Frunza, E. Tintea, D. Bartos, A. Ciobanu, I. Popescu, N. Toma, C. Gherghinescu, D. Cretu, N. Patrascu, C. Stoicescu, C. Udroiu, G. Bicescu, V. Vintila, D. Vinereanu, M. Cinteza, R. Rimbas, M. Grecu, A. Cozma, F. Boros, M. Ille, O. Tica, R. Tor, A. Corina, A. Jeewooth, B. Maria, C. Georgiana, C. Natalia, D. Alin, D. Dinu-Andrei, M. Livia, R. Daniela, R. Larisa, S. Umaar, T. Tamara, M. Ioachim Popescu, D. Nistor, I. Sus, O. Coborosanu, N. Alina-Ramona, R. Dan, L. Petrescu, G. Ionescu, I. Popescu, C. Vacarescu, E. Goanta, M. Mangea, A. Ionac, C. Mornos, D. Cozma, S. Pescariu, E. Solodovnicova, I. Soldatova, J. Shutova, L. Tjuleneva, T. Zubova, V. Uskov, D. Obukhov, G. Rusanova, I. Soldatova, N. Isakova, S. Odinsova, T. Arhipova, E. Kazakevich, E. Serdechnaya, O. Zavyalova, T. Novikova, I. Riabaia, S. Zhigalov, E. Drozdova, I. Luchkina, Y. Monogarova, D. Hegya, L. Rodionova, L. Rodionova, V. Nevzorova, I. Soldatova, O. Lusanova, A. Arandjelovic, D. Toncev, M. Milanov, N. Sekularac, M. Zdravkovic, S. Hinic, S. Dimkovic, T. Acimovic, J. Saric, M. Polovina, B. Vujisic-Tesic, M. Nedeljkovic, M. Zlatar, M. Asanin, V. Vasic, Z. Popovic, D. Djikic, M. Sipic, V. Peric, B. Dejanovic, N. Milosevic, A. Stevanovic, A. Andric, B. Pencic, M. Pavlovic-Kleut, V. Celic, M. Pavlovic, M. Petrovic, M. Vuleta, N. Petrovic, S. Simovic, Z. Savovic, S. Milanov, G. Davidovic, V. Iric-Cupic, D. Simonovic, M. Stojanovic, S. Stojanovic, V. Mitic, V. Ilic, D. Petrovic, M. Deljanin Ilic, S. Ilic, V. Stoickov, S. Markovic, S. Kovacevic, A. García Fernandez, A. Perez Cabeza, M. Anguita, L. Tercedor Sanchez, E. Mau, J. Loayssa, M. Ayarra, M. Carpintero, I. Roldán Rabadan, M. Leal, M. Gil Ortega, A. Tello Montoliu, E. Orenes Piñero, S. Manzano Fernández, F. Marín, A. Romero Aniorte, A. Veliz Martínez, M. Quintana Giner, G. Ballesteros, M. Palacio, O. Alcalde, I. García-Bolao, V. Bertomeu Gonzalez, F. Otero-Raviña, J. García Seara, J. Gonzalez Juanatey, N. Dayal, P. Maziarski, P. Gentil-Baron, D. Shah, M. Koç, E. Onrat, I. E. Dural, K. Yilmaz, B. Özin, S. Tan Kurklu, Y. Atmaca, U. Canpolat, L. Tokgozoglu, A. K. Dolu, B. Demirtas, D. Sahin, O. Ozcan Celebi, E. Diker, G. Gagirci, U. O. Turk, H. Ari, N. Polat, N. Toprak, M. Sucu, O. Akin Serdar, A. Taha Alper, A. Kepez, Y. Yuksel, A. Uzunselvi, S. Yuksel, M. Sahin, O. Kayapinar, T. Ozcan, H. Kaya, M. B. Yilmaz, M. Kutlu, M. Demir, C. Gibbs, S. Kaminskiene, M. Bryce, A. Skinner, G. Belcher, J. Hunt, L. Stancombe, B. Holbrook, C. Peters, S. Tettersell, A. Shantsila, D. Lane, K. Senoo, K. Russell, P. Domingos, S. Hussain, J. Partridge, R. Haynes, S. Bahadur, R. Brown, S. McMahon, J. McDonald, K. Balachandran, R. Singh, S. Garg, H. Desai, K. Davies, W. Goddard, G. Galasko, I. Rahman, Y. Chua, O. Payne, S. Preston, O. Brennan, L. Pedley, C. Whiteside, C. Dickinson, J. Brown, K. Jones, L. Benham, R. Brady, L. Buchanan, A. Ashton, H. Crowther, H. Fairlamb, S. Thornthwaite, C. Relph, A. McSkeane, U. Poultney, N. Kelsall, P. Rice, T. Wilson, M. Wrigley, R. Kaba, T. Patel, E. Young, J. Law, C. Runnett, H. Thomas, H. McKie, J. Fuller, S. Pick, A. Sharp, A. Hunt, K. Thorpe, C. Hardman, E. Cusack, L. Adams, M. Hough, S. Keenan, A. Bowring, J. Watts, J. Zaman, K. Goffin, H. Nutt, Y. Beerachee, J. Featherstone, C. Mills, J. Pearson, L. Stephenson, S. Grant, A. Wilson, C. Hawksworth, I. Alam, M. Robinson, S. Ryan, R. Egdell, E. Gibson, M. Holland, D. Leonard, B. Mishra, S. Ahmad, H. Randall, J. Hill, L. Reid, M. George, S. McKinley, L. Brockway, W. Milligan, J. Sobolewska, J. Muir, L. Tuckis, L. Winstanley, P. Jacob, S. Kaye, L. Morby, A. Jan, T. Sewell, C. Boos, B. Wadams, C. Cope, P. Jefferey, N. Andrews, A. Getty, A. Suttling, C. Turner, K. Hudson, R. Austin, S. Howe, R. Iqbal, N. Gandhi, K. Brophy, P. Mirza, E. Willard, S. Collins, N. Ndlovu, E. Subkovas, V. Karthikeyan, L. Waggett, A. Wood, A. Bolger, J. Stockport, L. Evans, E. Harman, J. Starling, L. Williams, V. Saul, M. Sinha, L. Bell, S. Tudgay, S. Kemp, J. Brown, L. Frost, T. Ingram, A. Loughlin, C. Adams, M. Adams, F. Hurford, C. Owen, C. Miller, D. Donaldson, H. Tivenan, H. Button, A. Nasser, O. Jhagra, B. Stidolph, C. Brown, C. Livingstone, M. Duffy, P. Madgwick, P. Roberts, E. Greenwood, L. Fletcher, M. Beveridge, S. Earles, D. McKenzie, D. Beacock, M. Dayer, M. Seddon, D. Greenwell, F. Luxton, F. Venn, H. Mills, J. Rewbury, K. James, K. Roberts, L. Tonks, D. Felmeden, W. Taggu, A. Summerhayes, D. Hughes, J. Sutton, L. Felmeden, M. Khan, E. Walker, L. Norris, L. O’Donohoe, A. Mozid, H. Dymond, H. Lloyd-Jones, G. Saunders, D. Simmons, D. Coles, D. Cotterill, S. Beech, S. Kidd, B. Wrigley, S. Petkar, A. Smallwood, R. Jones, E. Radford, S. Milgate, S. Metherell, V. Cottam, C. Buckley, A. Broadley, D. Wood, J. Allison, K. Rennie, L. Balian, L. Howard, L. Pippard, S. Board, T. Pitt-Kerby

The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial

Hila Zelicha, Nora Kloting, Alon Kaplan, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Yoash Chassidim, Matthias Bluher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Rita Nana Quayson, Martin von Bergen, Beatrice Engelmann, Ulrike E. Rolle-Kampczyk, Sven-Bastiaan Haange, Kieran M. Tuohy, Camilla Diotallevi, Ilan Shelef, Frank B. Hu, Meir J. Stampfer, Iris Shai

A healthy lifestyle is positively associated with mental health and well-being and core markers in ageing

Pauline Hautekiet, Nelly D. Saenen, Dries S. Martens, Margot Debay, Johan Van der Heyden, Tim S. Nawrot, Eva M. De Clercq

Empirical evidence of study design biases in nutrition randomised controlled trials: a meta-epidemiological study

Julia Stadelmaier, Isabelle Roux, Maria Petropoulou, Lukas Schwingshackl

From screening to treatment: the new landscape of diabetic kidney disease

C. Elena Cervantes, Mohamad Hanouneh, Bernard G. Jaar

Post-mortem examination of high mortality in patients with heart failure and atrial fibrillation

Otilia Țica, Ovidiu Țica, Karina V. Bunting, Joseph deBono, Georgios V. Gkoutos, Mircea I. Popescu, Dipak Kotecha

Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies

Taylor B. Cavazos, Linda Kachuri, Rebecca E. Graff, Jovia L. Nierenberg, Khanh K. Thai, Stacey Alexeeff, Stephen Van Den Eeden, Douglas A. Corley, Lawrence H. Kushi, Goncalo Abecasis, Aris Baras, Michael Cantor, Giovanni Coppola, Andrew Deubler, Aris Economides, Katia Karalis, Luca A. Lotta, John D. Overton, Jeffrey G. Reid, Katherine Siminovitch, Alan Shuldiner, Christina Beechert, Caitlin Forsythe, Erin D. Fuller, Zhenhua Gu, Michael Lattari, Alexander Lopez, John D. Overton, Maria Sotiropoulos Padilla, Manasi Pradhan, Kia Manoochehri, Thomas D. Schleicher, Louis Widom, Sarah E. Wolf, Ricardo H. Ulloa, Amelia Averitt, Nilanjana Banerjee, Michael Cantor, Dadong Li, Sameer Malhotra, Deepika Sharma, Jeffrey Staples, Xiaodong Bai, Suganthi Balasubramanian, Suying Bao, Boris Boutkov, Siying Chen, Gisu Eom, Lukas Habegger, Alicia Hawes, Shareef Khalid, Olga Krasheninina, Rouel Lanche, Adam J. Mansfield, Evan K. Maxwell, George Mitra, Mona Nafde, Sean O’Keeffe, Max Orelus, Razvan Panea, Tommy Polanco, Ayesha Rasool, Jeffrey G. Reid, William Salerno, Jeffrey C. Staples, Kathie Sun, Jiwen Xin, Goncalo Abecasis, Joshua Backman, Amy Damask, Lee Dobbyn, Manuel Allen Revez Ferreira, Arkopravo Ghosh, Christopher Gillies, Lauren Gurski, Eric Jorgenson, Hyun Min Kang, Michael Kessler, Jack Kosmicki, Alexander Li, Nan Lin, Daren Liu, Adam Locke, Jonathan Marchini, Anthony Marcketta, Joelle Mbatchou, Arden Moscati, Charles Paulding, Carlo Sidore, Eli Stahl, Kyoko Watanabe, Bin Ye, Blair Zhang, Andrey Ziyatdinov, Marcus B. Jones, Jason Mighty, Lyndon J. Mitnaul, Thomas J. Hoffmann, Elad Ziv, Laurel A. Habel, Eric Jorgenson, Lori C. Sakoda, John S. Witte

Dense phenotyping from electronic health records enables machine learning-based prediction of preterm birth

Abin Abraham, Brian Le, Idit Kosti, Peter Straub, Digna R. Velez-Edwards, Lea K. Davis, J. M. Newton, Louis J. Muglia, Antonis Rokas, Cosmin A. Bejan, Marina Sirota, John A. Capra

Circulating serum metabolites as predictors of dementia: a machine learning approach in a 21-year follow-up of the Whitehall II cohort study

Marcos D. Machado-Fragua, Benjamin Landré, Mathilde Chen, Aurore Fayosse, Aline Dugravot, Mika Kivimaki, Séverine Sabia, Archana Singh-Manoux

LncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway

Ting Chen, Zhemin Shi, Yanmian Zhao, Xiaoxiang Meng, Sicong Zhao, Lina Zheng, Xiaohui Han, Zhimei Hu, Qingbin Yao, Huajiang Lin, Xiaoxiao Du, Kun Zhang, Tao Han, Wei Hong

Fibroids: yet another example of disparity in health?

New strategies to improve clinical outcomes for diabetic kidney disease

Thomas Forst, Chantal Mathieu, Francesco Giorgino, David C. Wheeler, Nikolaos Papanas, Roland E. Schmieder, Atef Halabi, Oliver Schnell, Marina Streckbein, Katherine R. Tuttle

Epigenetic and transcriptomic alterations in offspring born to women with type 1 diabetes (the EPICOM study)

Sine Knorr, Anne Skakkebæk, Jesper Just, Emma B. Johannsen, Christian Trolle, Søren Vang, Zuzana Lohse, Birgitte Bytoft, Peter Damm, Kurt Højlund, Dorte M. Jensen, Claus H. Gravholt

Risk of thyroid dysfunction associated with mRNA and inactivated COVID-19 vaccines: a population-based study of 2.3 million vaccine recipients

Carlos King Ho Wong, David Tak Wai Lui, Xi Xiong, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Ching Lung Cheung, Chi Ho Lee, Yu Cho Woo, Ivan Chi Ho Au, Matthew Shing Hin Chung, Franco Wing Tak Cheng, Kathryn Choon Beng Tan, Ian Chi Kei Wong

Effectiveness of early rhythm control in improving clinical outcomes in patients with atrial fibrillation: a systematic review and meta-analysis

Wengen Zhu, Zexuan Wu, Yugang Dong, Gregory Y. H. Lip, Chen Liu

A differentiated digital intervention to improve antiretroviral therapy adherence among men who have sex with men living with HIV in China: a randomized controlled trial

Kedi Jiao, Chunmei Wang, Meizhen Liao, Jing Ma, Dianmin Kang, Weiming Tang, Joseph D. Tucker, Wei Ma

A multicenter, double-blind, randomized, parallel-group, placebo-controlled study to evaluate the efficacy and safety of camostat mesilate in patients with COVID-19 (CANDLE study)

Taku Kinoshita, Masahiro Shinoda, Yasuhiro Nishizaki, Katsuya Shiraki, Yuji Hirai, Yoshiko Kichikawa, Kenji Tsushima, Masaharu Shinkai, Naoyuki Komura, Kazuo Yoshida, Yasutoshi Kido, Hiroshi Kakeya, Naoto Uemura, Junichi Kadota

Effectiveness of rectal artesunate as pre-referral treatment for severe malaria in children under 5 years of age: a multi-country observational study

Manuel W. Hetzel, Jean Okitawutshu, Antoinette Tshefu, Elizabeth Omoluabi, Phyllis Awor, Aita Signorell, Nina C. Brunner, Jean-Claude Kalenga, Babatunde K. Akano, Kazeem Ayodeji, Charles Okon, Ocheche Yusuf, Proscovia Athieno, Joseph Kimera, Gloria Tumukunde, Irene Angiro, Giulia Delvento, Tristan T. Lee, Mark J. Lambiris, Marek Kwiatkowski, Nadja Cereghetti, Theodoor Visser, Harriet G. Napier, Justin M. Cohen, Valentina Buj, Christian Burri, Christian Lengeler

Characterising social contacts under COVID-19 control measures in Africa

Zlatina Dobreva, Amy Gimma, Hana Rohan, Benjamin Djoudalbaye, Akhona Tshangela, Christopher I. Jarvis, Kevin van Zandvoort, Matthew Quaife

The UK Coronavirus Job Retention Scheme and smoking, alcohol consumption and vaping during the COVID-19 pandemic: evidence from eight longitudinal population surveys

Michael J. Green, Jane Maddock, Giorgio Di Gessa, Bożena Wielgoszewska, Sam Parsons, Gareth J. Griffith, Jazz Croft, Anna J. Stevenson, Charlotte F. Huggins, Charlotte Booth, Jacques Wels, Richard J. Silverwood, Praveetha Patalay, Alun D. Hughes, Nishi Chaturvedi, Laura D. Howe, Emla Fitzsimons, Srinivasa Vittal Katikireddi, George B. Ploubidis

Early onset of immune-mediated diseases in minority ethnic groups in the UK

Archana Sharma-Oates, Dawit T. Zemedikun, Kanta Kumar, John A. Reynolds, Avinash Jain, Karim Raza, John A. Williams, Laura Bravo, Victor Roth Cardoso, Georgios Gkoutos, Krishnarajah Nirantharakumar, Janet M. Lord

SARS-CoV-2 infection, vaccination, and antibody response trajectories in adults: a cohort study in Catalonia

Marianna Karachaliou, Gemma Moncunill, Ana Espinosa, Gemma Castaño-Vinyals, Rocío Rubio, Marta Vidal, Alfons Jiménez, Esther Prados, Anna Carreras, Beatriz Cortés, Natàlia Blay, Marc Bañuls, Vanessa Pleguezuelos, Natalia Rodrigo Melero, Pau Serra, Daniel Parras, Luis Izquierdo, Pere Santamaría, Carlo Carolis, Kyriaki Papantoniou, Ximena Goldberg, Ruth Aguilar, Judith Garcia-Aymerich, Rafael de Cid, Manolis Kogevinas, Carlota Dobaño

Identification of risk factors for incident cervical insufficiency in nulliparous and parous women: a population-based case-control study

Lili Meng, Sara Öberg, Anna Sandström, Chen Wang, Marie Reilly

Non-invasive assessment of HFpEF in mouse models: current gaps and future directions

María Villalba-Orero, Pablo Garcia-Pavia, Enrique Lara-Pezzi

Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data

Kasia Stepniewska, Elizabeth N. Allen, Georgina S. Humphreys, Eugenie Poirot, Elaine Craig, Kalynn Kennon, Daniel Yilma, Teun Bousema, Philippe J. Guerin, Nicholas J. White, Ric N. Price, Jaishree Raman, Andreas Martensson, Richard O. Mwaiswelo, Germana Bancone, Guido J. H. Bastiaens, Anders Bjorkman, Joelle M. Brown, Umberto D’Alessandro, Alassane A. Dicko, Badria El-Sayed, Salah-Eldin Elzaki, Alice C. Eziefula, Bronner P. Gonçalves, Muzamil Mahdi Abdel Hamid, Akira Kaneko, Simon Kariuki, Wasif Khan, Titus K. Kwambai, Benedikt Ley, Billy E. Ngasala, Francois Nosten, Joseph Okebe, Aaron M. Samuels, Menno R. Smit, Will J. R. Stone, Inge Sutanto, Feiko Ter Kuile, Roger C. Tine, Alfred B. Tiono, Chris J. Drakeley, Roly Gosling, Andy Stergachis, Karen I. Barnes, Ingrid Chen

Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Fabian Eichelmann, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Bas Bueno-de-Mesquita, Karina Standahl Olsen, Torkjel Manning Sandanger, Therese Haugdahl Nøst, J. Ramón Quirós, Catalina Bonet, Miguel Rodríguez Barranco, María-Dolores Chirlaque, Eva Ardanaz, Malte Sandsveden, Jonas Manjer, Linda Vidman, Matilda Rentoft, David Muller, Kostas Tsilidis, Alicia K. Heath, Hector Keun, Jerzy Adamski, Pekka Keski-Rahkonen, Augustin Scalbert, Marc J. Gunter, Vivian Viallon

The duration of protection against clinical malaria provided by the combination of seasonal RTS,S/AS01E vaccination and seasonal malaria chemoprevention versus either intervention given alone

Matthew Cairns, Amadou Barry, Issaka Zongo, Issaka Sagara, Serge R. Yerbanga, Modibo Diarra, Charles Zoungrana, Djibrilla Issiaka, Abdoul Aziz Sienou, Amadou Tapily, Koualy Sanogo, Mahamadou Kaya, Seydou Traore, Kalifa Diarra, Hama Yalcouye, Youssoufa Sidibe, Alassane Haro, Ismaila Thera, Paul Snell, Jane Grant, Halidou Tinto, Paul Milligan, Daniel Chandramohan, Brian Greenwood, Alassane Dicko, Jean Bosco Ouedraogo

Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel Jr, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon, Anna-Barbara Moscicki, Richard M. Novak, Mickey V. Patel, Intira Sriprasert, Andrea R. Thurman, Sergey Yegorov, Nelly Rwamba Mugo, Alison C. Roxby, Elizabeth Micks, Florian Hladik, Salim S. Abdool Karim, Max Abou, Sharon M. Anderson, Aura Andreasen, Trong T. Ao, David F. Archer, Kevin K. Arien, Kelly B. Arnold, Susana Asin, Susan Baden, Bernard S. Bagaya, Kathy Baisley, Emma Barnard, Angela Bartolf, Brian A. Bernick, Kenzie Birse, Andrea K. Boggild, Genevieve Boily-Larouche, Lucy A. Boksa, Brittany A. Bowman, Fredrick P. Bowman, Kristina Broliden, Adam D. Burgener, Jozefien Buyze, Elizabeth H. Byrne, Neelima Chandra, Stacey Chapman, Hua Yun Chen, Juliana Cheruiyot, Ralph R. Chesson, Kathleen E. Cohen, Piet Cools, Catherine Cosgrove, Gary R. Coulton, Peggy A. Crowley-Nowick, Tania Crucitti, Tina D. Cunningham, Susan Cu-Uvin, Hassan Y. Dawood, Sinead Delany-Moretlwe, Krista L. Dong, Betty A. Donoval, Brenden Dufault, Kathleen Dunlap, Laura J. Dunphy, Robert P. Edwards, Lars Engstrand, Terri Espinosa, John V. Fahey, Titilayo Fashemi, J. Dennis Fortenberry, Jamie L. Freiermuth, Ronald M. Galiwango, Musie S. Ghebremichael, Sara V. Good, Odin Goovaerts, Parrie J. Graham, Liselotte Hardy, Klara Hasselrot, Richard J. Hayes, Betsy C. Herold, Carolina Herrera, Ronald C. Hershow, Allan Hildesheim, Sharon Hillier, Yanwen Hou, Hazel Huang, Sean M. Hughes, Loris Y. Hwang, Andrea Introini, Nasreen Ismail, Terry Jacot, Mariel Jais, Vicky Jespers, Vineet Joag, Christine Johnston, Clifford Jones, Sarah Joseph, Saidi Kapiga, John C. Kappes, Joshua Kimani, Makobu Kimani, Thomas Kimble, Noah Kiwanuka, Monika Kowatsch, Jessie Kwatampora, Douglas S. Kwon, Julie Lajoie, Alan Landay, Douglas A. Lauffenburger, Dara A. Lehman, Alasdair Leslie, Lenine J. Liebenberg, Jay A. Lieberman, Vitali Lounev, Yifei Ma, Amanda Mabhula, Jennifer Mabuka, Kaballa Maganja, Jeanne Marrazzo, Lindi Masson, Kenneth H. Mayer, Stuart McCorrister, Joris Menten, Pedro M. M. Mesquita, Johan Michiels, Sebastian Mirkin, Amber Moodley, Juliet Mpendo, Lucy R. Mukura, Mary Mwaura, Gilles Ndayisaba, Thumbi Ndung’u, Jane Njoki, Laura Noel-Romas, Billy Nyanga, Christina Ochsenbauer, Katherine Odem-Davis, Gregory S. Olson, Kenneth Omollo, Donald P. Orr, Julie Overbaugh, Julius Oyugi, Nikita Padavattan, Tarita Pakrashi, Urvashi Pandey, Jo-Ann S. Passmore, Terri Pustilnik, Lorna Rabe, Nicola Richardson-Harman, Christiane Rollenhagen, Laura Romas, Richard M. Rossoll, Jill L. Schwartz, Mark E. Scott, Maike Seifert, A. Shah, Kamnoosh Shahabi, Robin J. Shattock, Zheng Shen, Baochen Shi, Sengeziwe Sibeko, Yan Song, Gregory Spear, Brian S. Starkman, Howard D. Strickler, Jan L. Sumerel, Egbert Tannich, Katherine P. Theall, Annelie Tjernlund, Janneke van de Wijgert, Barbara Van Der Pol, Guido Vanham, Bruce D. Walker, Joan L. Walker, Deborah Watson-Jones, Hugo Wefer, Garrett R. Westmacott, Charles R. Wira, Peter F. Wright, Naji Younes, Nazita Yousefieh

Maintaining healthy sleep patterns and frailty transitions: a prospective Chinese study

Yunqing Zhu, Junning Fan, Jun Lv, Yu Guo, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Feifei Li, Xiaoming Yang, Daniel Avery, Junshi Chen, Zhengming Chen, Canqing Yu, Liming Li, Robert Clarke, Rory Collins, Richard Peto, Robin Walters, Derrick Bennett, Ruth Boxall, Sue Burgess, Ka Hung Chan, Yumei Chang, Johnathan Clarke, Robert Clarke, Ahmed Edris Mohamed, Zammy Fairhurst-Hunter, Hannah Fry, Simon Gilbert, Alex Hacker, Mike Hill, Michael Holmes, Pek Kei Im, Andri Iona, Maria Kakkoura, Christiana Kartsonaki, Rene Kerosi, Kuang Lin, Mohsen Mazidi, Iona Millwood, Sam Morris, Qunhua Nie, Alfred Pozarickij, Paul Ryder, Saredo Said, Sam Sansome, Dan Schmidt, Paul Sherliker, Rajani Sohoni, Becky Stevens, Iain Turnbull, Robin Walters, Lin Wang, Neil Wright, Pang Yao, Yu Guo, Xiao Han, Can Hou, Jun Lv, Pei Pei, Chao Liu, Qingmei Xia, Zengchang Pang, Ruqin Gao, Shanpeng Li, Haiping Duan, Shaojie Wang, Yongmei Liu, Ranran Du, Yajing Zang, Liang Cheng, Xiaocao Tian, Hua Zhang, Yaoming Zhai, Feng Ning, Xiaohui Sun, Silu Lv, Junzheng Wang, Wei Hou, Wei Sun, Shichun Yan, Xiaoming Cui, Chi Wang, Zhenyuan Wu, Yanjie Li, Quan Kang, Huiming Luo, Tingting Ou, Xiangyang Zheng, Zhendong Guo, Shukuan Wu, Yilei Li, Huimei Li, Ming Wu, Yonglin Zhou, Jinyi Zhou, Ran Tao, Jie Yang, Jian Su, Fang Liu, Jun Zhang, Yihe Hu, Yan Lu, Liangcai Ma, Aiyu Tang, Shuo Zhang, Jianrong Jin, Jingchao Liu, Mei Lin, Zhenzhen Lu, Lifang Zhou, Changping Xie, Jian Lan, Tingping Zhu, Yun Liu, Liuping Wei, Liyuan Zhou, Ningyu Chen, Yulu Qin, Sisi Wang, Xianping Wu, Ningmei Zhang, Xiaofang Chen, Xiaoyu Chang, Mingqiang Yuan, Xia Wu, Xiaofang Chen, Wei Jiang, Jiaqiu Liu, Qiang Sun, Faqing Chen, Xiaolan Ren, Caixia Dong, Hui Zhang, Enke Mao, Xiaoping Wang, Tao Wang, Xi Zhang, Kai Kang, Shixian Feng, Huizi Tian, Lei Fan, Xiao Lin Li, Huarong Sun, Pan He, Xukui Zhang, Min Yu, Ruying Hu, Hao Wang, Xiaoyi Zhang, Yuan Cao, Kaixu Xie, Lingli Chen, Dun Shen, Xiaojun Li, Donghui Jin, Li Yin, Huilin Liu, Zhongxi Fu, Xin Xu, Hao Zhang, Jianwei Chen, Yuan Peng, Libo Zhang, Chan Qu

An empirical evaluation of the impact scenario of pooling bodies of evidence from randomized controlled trials and cohort studies in medical research

Nils Bröckelmann, Julia Stadelmaier, Louisa Harms, Charlotte Kubiak, Jessica Beyerbach, Martin Wolkewitz, Jörg J. Meerpohl, Lukas Schwingshackl

Characterization of data-driven clusters in diabetes-free adults and their utility for risk stratification of type 2 diabetes

Diego Yacamán Méndez, Minhao Zhou, Ylva Trolle Lagerros, Donaji V. Gómez Velasco, Per Tynelius, Hrafnhildur Gudjonsdottir, Antonio Ponce de Leon, Katarina Eeg-Olofsson, Claes-Göran Östenson, Boel Brynedal, Carlos A. Aguilar Salinas, David Ebbevi, Anton Lager

A collaborative editorial model supports research integrity

Influence of baseline arterial stiffness on effects of intensive compared with standard blood pressure control: a post hoc analysis of the STEP trial

Qirui Song, Qianhui Ling, Jingjing Bai, Hongwei Zhang, Peili Bu, Fang Chen, Shouling Wu, Weili Zhang, Mulei Chen, Jun Cai

Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential to promote treatment of viral diseases

Shu Shen, Yaxian Zhang, Zhiyun Yin, Qiong Zhu, Jingyuan Zhang, Tiantian Wang, Yaohui Fang, Xiaoli Wu, Yuan Bai, Shiyu Dai, Xijia Liu, Jiayin Jin, Shuang Tang, Jia Liu, Manli Wang, Yu Guo, Fei Deng

Development and validation of a simple tool composed of items on dyspnea, respiration rates, and C-reactive protein for pneumonia prediction among acute febrile respiratory illness patients in primary care settings

Fengming Ding, Lei Han, Dongning Yin, Yan Zhou, Yong Ji, Pengyu Zhang, Wensheng Wu, Jijing Chen, Zufang Wang, Xinxin Fan, Guoqing Zhang, Min Zhang

Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass

Jiang-Wei Xia, Lin Zhang, Jin Li, Cheng-Da Yuan, Xiao-Wei Zhu, Yu Qian, Saber Khederzadeh, Jia-Xuan Gu, Lin Xu, Jian-Hua Gao, Ke-Qi Liu, David Karasik, Shu-Yang Xie, Guo-Bo Chen, Hou-Feng Zheng

Metabolomic profile of prostate cancer-specific survival among 1812 Finnish men

Jiaqi Huang, Bin Zhao, Stephanie J. Weinstein, Demetrius Albanes, Alison M. Mondul

Transparency and reporting characteristics of COVID-19 randomized controlled trials

Philipp Kapp, Laura Esmail, Lina Ghosn, Philippe Ravaud, Isabelle Boutron

Neutrophil degranulation and severely impaired extracellular trap formation at the basis of susceptibility to infections of hemodialysis patients

Salti Talal, Khoury Mona, Awad Karem, Lerenthal Yaniv, Harari-Misgav Reut, Shemesh Ariel, Avraham-Kelbert Moran, Eitam Harel, Salvatore Campisi-Pinto, Abu-Amna Mahmoud, Colodner Raul, Tovbin David, Bar-Sela Gil, Cohen Idan

NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma

Yizhi Zhan, Zhanqiao Zhang, Yuechen Liu, Yuan Fang, Yuwen Xie, Yilin Zheng, Guoxin Li, Li Liang, Yi Ding

Depression and fatigue in active IBD from a microbiome perspective—a Bayesian approach to faecal metagenomics

Anne Kerstin Thomann, Torsten Wüstenberg, Jakob Wirbel, Laura-Louise Knoedler, Philipp Arthur Thomann, Georg Zeller, Matthias Philip Ebert, Stefanie Lis, Wolfgang Reindl

Feasibility and outcome of reproducible clinical interpretation of high-dimensional molecular data: a comparison of two molecular tumor boards

Damian T. Rieke, Till de Bortoli, Peter Horak, Mario Lamping, Manuela Benary, Ivan Jelas, Gina Rüter, Johannes Berger, Marit Zettwitz, Niklas Kagelmann, Andreas Kind, Falk Fabian, Dieter Beule, Hanno Glimm, Benedikt Brors, Albrecht Stenzinger, Stefan Fröhling, Ulrich Keilholz

NeRD: a multichannel neural network to predict cellular response of drugs by integrating multidimensional data

Xiaoxiao Cheng, Chong Dai, Yuqi Wen, Xiaoqi Wang, Xiaochen Bo, Song He, Shaoliang Peng

Clinical implications of circulating tumor DNA in predicting the outcome of diffuse large B cell lymphoma patients receiving first-line therapy

Miaomiao Li, Lan Mi, Chunyang Wang, Xiaojuan Wang, Jianhua Zhu, Fei Qi, Hui Yu, Yingying Ye, Dedao Wang, Jiaowu Cao, Dingyao Hu, Quanyu Yang, Dandan Zhao, Tonghui Ma, Yuqin Song, Jun Zhu

Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa

Kesego Tapela, Fatima O. Oyawoye, Charles Ochieng’ Olwal, Precious C. Opurum, Jones Amo Amponsah, Kekeli Aku Lumor Segbedzi, Becky Tetteh, Frederick Kumi-Ansah, Joe K. Mutungi, Evangeline Obodai, Emmanuella Amoako, Seth Agyemang, Nicaise Tuikue Ndam, William Kwabena Ampofo, Julian C. Rayner, Gordon A. Awandare, Lily Paemka, Yaw Bediako, Peter Kojo Quashie

Clinical impact of lipid injectable emulsion in internal medicine inpatients exclusively receiving parenteral nutrition: a propensity score matching analysis from a Japanese medical claims database

Kosei Takagi, Kenta Murotani, Satoru Kamoshita, Akiyoshi Kuroda

Heterogeneity in pragmatic randomised trials: sources and management

Bruno Giraudeau, Agnès Caille, Sandra M. Eldridge, Charles Weijer, Merrick Zwarenstein, Monica Taljaard

Metabolomics analysis of type 2 diabetes remission identifies 12 metabolites with predictive capacity: a CORDIOPREV clinical trial study

Marina Mora-Ortiz, Juan F. Alcala-Diaz, Oriol Alberto Rangel-Zuñiga, Antonio Pablo Arenas-de Larriva, Fernando Abollo-Jimenez, Diego Luque-Cordoba, Feliciano Priego-Capote, Maria M. Malagon, Javier Delgado-Lista, Jose M. Ordovas, Pablo Perez-Martinez, Antonio Camargo, Jose Lopez-Miranda

Effects of dabigatran versus warfarin on 2-year cognitive outcomes in old patients with atrial fibrillation: results from the GIRAF randomized clinical trial

Bruno Caramelli, Pai Ching Yu, Francisco A. M. Cardozo, Iuri R. Magalhães, Raphael R. Spera, Daniel K. Amado, Maria C. Escalante-Rojas, Danielle M. Gualandro, Daniela Calderaro, Caio A. M. Tavares, Flavio A. Borges-Junior, Adriana F. Pastana, Mariana G. Matheus, Sonia M. D. Brucki, Ana Carolina O. Rodrigues, Ricardo Nitrini, Paulo Caramelli

Ambient air pollution associated with incidence and dynamic progression of type 2 diabetes: a trajectory analysis of a population-based cohort

Yinglin Wu, Shiyu Zhang, Samantha E. Qian, Miao Cai, Haitao Li, Chongjian Wang, Hongtao Zou, Lan Chen, Michael G. Vaughn, Stephen Edward McMillin, Hualiang Lin

SIRPα antibody combined with oncolytic virus OH2 protects against tumours by activating innate immunity and reprogramming the tumour immune microenvironment

Defeng Kong, Zhenrong Yang, Guoliang Li, Quanyou Wu, Zhaoru Gu, Duo Wan, Qi Zhang, Xiaoli Zhang, Shujun Cheng, Binlei Liu, Kaitai Zhang, Wen Zhang

Methylene blue for intractable pain from oral mucositis related to cancer treatment: a randomized phase 2 clinical trial

Carlos J. Roldan, Billy Huh, Juhee Song, Yago Nieto, Joyce Osei, Thomas Chai, Kent Nouri, Lakshmi Koyyalagunta, Eduardo Bruera

The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls—a prospective cohort study

Ingrid Egeland Christensen, Ingrid Jyssum, Anne Therese Tveter, Joseph Sexton, Trung T. Tran, Siri Mjaaland, Grete Birkeland Kro, Tore K. Kvien, David John Warren, Jørgen Jahnsen, Ludvig A. Munthe, Espen A. Haavardsholm, John Torgils Vaage, Gunnveig Grødeland, Fridtjof Lund-Johansen, Kristin Kaasen Jørgensen, Silje Watterdal Syversen, Guro Løvik Goll, Sella Aarrestad Provan

Sustained seropositivity up to 20.5 months after COVID-19

Carlota Dobaño, Anna Ramírez-Morros, Selena Alonso, Rocío Rubio, Gemma Ruiz-Olalla, Josep Vidal-Alaball, Dídac Macià, Queralt Miró Catalina, Marta Vidal, Aina Fuster Casanovas, Esther Prados de la Torre, Diana Barrios, Alfons Jiménez, Jasmina Zanoncello, Natalia Rodrigo Melero, Carlo Carolis, Luis Izquierdo, Ruth Aguilar, Gemma Moncunill, Anna Ruiz-Comellas

Speech silence character as a diagnostic biomarker of early cognitive decline and its functional mechanism: a multicenter cross-sectional cohort study

Hua-Long Wang, Ran Tang, Ru-Jing Ren, Eric B. Dammer, Qi-Hao Guo, Guo-Ping Peng, Hai-Lun Cui, You-Min Zhang, Jin-Tao Wang, Xin-Yi Xie, Qiang Huang, Jian-Ping Li, Fu-Hua Yan, Sheng-Di Chen, Na-Ying He, Gang Wang

Effectiveness of letters to patients with or without Cochrane blogshots on 10-year cardiovascular risk change among women in menopausal transition: 6-month three-arm randomized controlled trial

Slavica Jurić Petričević, Ivan Buljan, Dora Bjelanović, Nataša Mrduljaš-Đujić, Tanja Pekez, Mario Ćurković, Željko Vojvodić, Ivančica Pavličević, Matko Marušić, Ana Marušić

Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident cardiovascular disease

Xue Tian, Shuohua Chen, Yingting Zuo, Yijun Zhang, Xiaoli Zhang, Qin Xu, Yanxia Luo, Shouling Wu, Anxin Wang

Investigation of the causal relationship between ALS and autoimmune disorders: a Mendelian randomization study

Paria Alipour, Konstantin Senkevich, Jay P. Ross, Dan Spiegelman, Despoina Manousaki, Patrick A. Dion, Guy A. Rouleau

Comprehensive approach to costing cervical cancer prevention and control: a case study in the United Republic of Tanzania using the Cervical Cancer Prevention and Control Costing (C4P) tool

Ann Levin, Safina Yuma, Edwin Swai, Winthrop Morgan, Cindy L. Gauvreau, Nathalie Broutet, Karene Hoi Ting Yeung, Raymond Hutubessy

Polygenic risk score improves the accuracy of a clinical risk score for coronary artery disease

Austin King, Lang Wu, Hong-Wen Deng, Hui Shen, Chong Wu

Hesitancy for receiving regular SARS-CoV-2 vaccination in UK healthcare workers: a cross-sectional analysis from the UK-REACH study

Neyme Veli, Christopher A. Martin, Katherine Woolf, Joshua Nazareth, Daniel Pan, Amani Al-Oraibi, Rebecca F. Baggaley, Luke Bryant, Laura B. Nellums, Laura J. Gray, Kamlesh Khunti, Manish Pareek, Anna L. Guyatt, Catherine John, I. Chris McManus, Ibrahim Abubakar, Amit Gupta, Keith R. Abrams, Martin D. Tobin, Louise Wain, Sue Carr, Edward Dove, David Ford, Robert Free

Identifying optimal vaccination scenarios to reduce varicella zoster virus transmission and reactivation

Kevin M Bakker, Marisa C Eisenberg, Robert J Woods, Micaela E Martinez

A cross-sectional study evidences regulations of leukocytes in the colostrum of mothers with obesity

Raúl Piñeiro-Salvador, Eduardo Vazquez-Garza, José Antonio Cruz-Cardenas, Cuauhtémoc Licona-Cassani, Gerardo García-Rivas, Jorge Moreno-Vásquez, Mario René Alcorta-García, Victor Javier Lara-Diaz, Marion E. G. Brunck

Mediating effect of vascular risk factors underlying the link between gestational diabetes and cardiovascular disease

Ravi Retnakaran, Baiju R. Shah

Association of maternal levothyroxine use during pregnancy with offspring birth and neurodevelopmental outcomes: a population-based cohort study

Grace Mengqin Ge, Edmund C. L. Cheung, Kenneth K. C. Man, Patrick Ip, Wing Cheong Leung, Gloria H. Y. Li, Annie W. C. Kung, Ching-Lung Cheung, Ian C. K. Wong

Prophylactic antibiotic use during labor and delivery in China: a nationwide, multicenter, hospital-based, cross-sectional study

Qiguo Lian, Tao Zheng, Xiaona Huo, Jun Zhang, Lin Zhang

Molecular testing to deliver personalized chemotherapy recommendations: risking over and undertreatment

Timothée Olivier, Vinay Prasad

Systematic evaluation of the pre-eclampsia drugs, dietary supplements and biologicals pipeline using target product profiles

Annie R. A. McDougall, Roxanne Hastie, Maya Goldstein, Andrew Tuttle, Stephen Tong, Anne Ammerdorffer, A. Metin Gülmezoglu, Joshua P. Vogel

The impact of cardiovascular health and frailty on mortality for males and females across the life course

Jack Quach, Olga Theou, Judith Godin, Kenneth Rockwood, Dustin Scott Kehler

Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood

Remco T. P. van Cruchten, Daniël van As, Jeffrey C. Glennon, Baziel G. M. van Engelen, Peter A. C. ‘t Hoen, K Okkersen, C Jimenez-Moreno, S Wenninger, F Daidj, S Cumming, R Littleford, D G Monckton, H Lochmüller, M Catt, C G Faber, A Hapca, P T Donnan, G Gorman, G Bassez, B Schoser, H Knoop, S Treweek, Derick G. Wansink, Francis Impens, Ralf Gabriels, Tine Claeys, Aymeric Ravel-Chapuis, Bernard J. Jasmin, Niamh Mahon, Sylvia Nieuwenhuis, Lennart Martens, Petr Novak, Denis Furling, Arie Baak, Genevieve Gourdon, Alex MacKenzie, Cecile Martinat, Nafisa Neault, Andreas Roos, Elise Duchesne, Renee Salz, Rachel Thompson, Sandrine Baghdoyan, Anu Mary Varghese, Paul Blom, Sally Spendiff, Alexander Manta

Gravidity and malaria trends interact to modify P. falciparum densities and detectability in pregnancy: a 3-year prospective multi-site observational study

Glória Matambisso, Nanna Brokhattingen, Sónia Maculuve, Pau Cisteró, Henriques Mbeve, Anna Escoda, Judice Miguel, Elena Buetas, Ianthe de Jong, Boaventura Cuna, Cardoso Melembe, Nelo Ndimande, Gemma Porras, Haily Chen, Kevin K. A. Tetteh, Chris Drakeley, Benoit Gamain, Chetan Chitnis, Virander Chauhan, Llorenç Quintó, Beatriz Galatas, Eusébio Macete, Alfredo Mayor

Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude, Johanna Lepeule

Dynamic monitoring of cerebrospinal fluid circulating tumor DNA to identify unique genetic profiles of brain metastatic tumors and better predict intracranial tumor responses in non-small cell lung cancer patients with brain metastases: a prospective cohort study (GASTO 1028)

Meichen Li, Jing Chen, Baishen Zhang, Juan Yu, Na Wang, Delan Li, Yang Shao, Dongqin Zhu, Chuqiao Liang, Yutong Ma, Qiuxiang Ou, Xue Hou, Likun Chen

Identification of a window of androgen sensitivity for somatic cell function in human fetal testis cultured ex vivo

Malene Lundgaard Riis, Gabriele Matilionyte, John E. Nielsen, Cecilie Melau, David Greenald, Kristine Juul Hare, Lea Langhoff Thuesen, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Anna-Maria Andersson, Jakob Albrethsen, Hanne Frederiksen, Ewa Rajpert-De Meyts, Anders Juul, Rod T. Mitchell, Anne Jørgensen

Effectiveness of inactivated and Ad5-nCoV COVID-19 vaccines against SARS-CoV-2 Omicron BA. 2 variant infection, severe illness, and death

Zhuoying Huang, Shuangfei Xu, Jiechen Liu, Linlin Wu, Jing Qiu, Nan Wang, Jia Ren, Zhi Li, Xiang Guo, Fangfang Tao, Jian Chen, Donglei Lu, Xiaodong Sun, Weibing Wang

Correction: Optimising a person-centred approach to stopping medicines in older people with multimorbidity and polypharmacy using the DExTruS framework: a realist review

Amadea Turk, Geoffrey Wong, Kamal R. Mahtani, Michelle Maden, Ruaraidh Hill, Ed Ranson, Emma Wallace, Janet Krska, Dee Mangin, Richard Byng, Daniel Lasserson, Joanne Reeve

Efficacy of metformin therapy in patients with cancer: a meta-analysis of 22 randomised controlled trials

Jie Wen, Zhenjie Yi, Yuyao Chen, Jing Huang, Xueyi Mao, Liyang Zhang, Yu Zeng, Quan Cheng, Wenrui Ye, Zhixiong Liu, Fangkun Liu, Jingfang Liu

Immune-related histologic phenotype in pretreatment tumour biopsy predicts the efficacy of neoadjuvant anti-PD-1 treatment in squamous lung cancer

Pei Yuan, Changyuan Guo, Lin Li, Yun Ling, Lei Guo, Jianming Ying

Relationship of body mass index with frailty and all-cause mortality among middle-aged and older adults

Kulapong Jayanama, Olga Theou, Judith Godin, Andrea Mayo, Leah Cahill, Kenneth Rockwood

Trends in mortality from alcohol, opioid, and combined alcohol and opioid poisonings by sex, educational attainment, and race and ethnicity for the United States 2000–2019

Charlotte Buckley, Yu Ye, William C. Kerr, Nina Mulia, Klajdi Puka, Jürgen Rehm, Charlotte Probst

Head-to-head comparison of the accuracy of saliva and nasal rapid antigen SARS-CoV-2 self-testing: cross-sectional study

Ewoud Schuit, Roderick P. Venekamp, Irene K. Veldhuijzen, Wouter van den Bijllaardt, Suzan D. Pas, Joep J. J. M. Stohr, Esther B. Lodder, Marloes Hellwich, Richard Molenkamp, Zsofia Igloi, Constantijn Wijers, Irene H. Vroom, Carla R. S. Nagel-Imming, Wanda G. H. Han, Jan A. J. W. Kluytmans, Susan van den Hof, Janneke H. H. M. van de Wijgert, Karel G. M. Moons

Cost-effectiveness of folic acid therapy for primary prevention of stroke in patients with hypertension

Tiantian Zhang, Zhuoru Liang, Tengfei Lin, David J. Cohen, Alejandro Arrieta, Xiaobin Wang, Xianhui Qin, Binyan Wang, Yong Huo, Gordon G. Liu, Jie Jiang, Zugui Zhang

Bifunctional anti-PD-L1/TGF-βRII agent SHR-1701 in advanced solid tumors: a dose-escalation, dose-expansion, and clinical-expansion phase 1 trial

Dan Liu, Jun Zhou, Yongsheng Wang, Mingjun Li, Haiping Jiang, Yunpeng Liu, Xianli Yin, Minghua Ge, Xiaojun Xiang, Jieer Ying, Jian Huang, Yan-qiao Zhang, Ying Cheng, Zhigang Huang, Xianglin Yuan, Weiqing Han, Dong Yan, Xinshuai Wang, Pan Liu, Linna Wang, Xiaojing Zhang, Suxia Luo, Tianshu Liu, Lin Shen

Immunogenicity, efficacy, and safety of SARS-CoV-2 vaccine dose fractionation: a systematic review and meta-analysis

Bingyi Yang, Xiaotong Huang, Huizhi Gao, Nancy H. Leung, Tim K. Tsang, Benjamin J. Cowling

Assessing trial representativeness using serious adverse events: an observational analysis using aggregate and individual-level data from clinical trials and routine healthcare data

Peter Hanlon, Elaine Butterly, Anoop S. V. Shah, Laurie J. Hannigan, Sarah H. Wild, Bruce Guthrie, Frances S. Mair, Sofia Dias, Nicky J. Welton, David A. McAllister

Combination of an autophagy inhibitor with immunoadjuvants and an anti-PD-L1 antibody in multifunctional nanoparticles for enhanced breast cancer immunotherapy

Yibin Cheng, Caixia Wang, Huihui Wang, Zhiwei Zhang, Xiaopeng Yang, Yanming Dong, Lixin Ma, Jingwen Luo

Lycium barbarum polysaccharide improves dopamine metabolism and symptoms in an MPTP-induced model of Parkinson’s disease

Jiangbo Song, Lian Liu, Zhiquan Li, Ting Mao, Jianfei Zhang, Lei Zhou, Xin Chen, Yunzhu Shang, Tao Sun, Yuxin Luo, Yu Jiang, Duan Tan, Xiaoling Tong, Fangyin Dai

Alcohol consumption and hepatocellular carcinoma: novel insights from a prospective cohort study and nonlinear Mendelian randomization analysis

Zhenqiu Liu, Ci Song, Chen Suo, Hong Fan, Tiejun Zhang, Li Jin, Xingdong Chen

The causal associations of circulating amino acids with blood pressure: a Mendelian randomization study

Chenhao Lin, Zhonghan Sun, Zhendong Mei, Hailuan Zeng, Manying Zhao, Jianying Hu, Mingfeng Xia, Tao Huang, Chaolong Wang, Xin Gao, Yan Zheng

One day versus two days of hepatic arterial infusion with oxaliplatin and fluorouracil for patients with unresectable hepatocellular carcinoma

Zhicheng Lai, Yexing Huang, Dongsheng Wen, Xuanjia Lin, Anna Kan, Qijiong Li, Wei Wei, Minshan Chen, Li Xu, Minke He, Ming Shi

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Flavia Hodel, Olivier Naret, Clara Bonnet, Nicole Brenner, Noemi Bender, Tim Waterboer, Pedro Marques-Vidal, Peter Vollenweider, Jacques Fellay

Added flavors: potential contributors to body weight gain and obesity?

Nathalie Judith Neumann, Mathias Fasshauer

Maternal factors during pregnancy influencing maternal, fetal, and childhood outcomes

Louis J. Muglia, Katrien Benhalima, Stephen Tong, Susan Ozanne

Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk

Shannon D’Urso, Pooja Arumugam, Therese Weider, Liang-Dar Hwang, Tom A. Bond, John P. Kemp, Nicole M. Warrington, David M. Evans, Tracy A. O’Mara, Gunn-Helen Moen

The presence and impact of multimorbidity clusters on adverse outcomes across the spectrum of kidney function

Michael K. Sullivan, Juan-Jesus Carrero, Bhautesh Dinesh Jani, Craig Anderson, Alex McConnachie, Peter Hanlon, Dorothea Nitsch, David A. McAllister, Frances S. Mair, Patrick B. Mark, Alessandro Gasparini

Psoriasis and cardiovascular disease risk in European and East Asian populations: evidence from meta-analysis and Mendelian randomization analysis

Liming Zhang, Yuxiang Wang, Li Qiu, Jian Wu

Health-related quality of life among persons with initial mild, moderate, and severe or critical COVID-19 at 1 and 12 months after infection: a prospective cohort study

Anouk Verveen, Elke Wynberg, Hugo D. G. van Willigen, Udi Davidovich, Anja Lok, Eric P. Moll van Charante, Menno D. de Jong, Godelieve de Bree, Maria Prins, Hans Knoop, Pythia T. Nieuwkerk, Ivette Agard, Jane Ayal, Floor Cavdar, Marianne Craanen, Annemarieke Deuring, Annelies van Dijk, Ertan Ersan, Laura del Grande, Joost Hartman, Nelleke Koedoot, Tjalling Leenstra, Romy Lebbink, Dominique Loomans, Agata Makowska, Tom du Maine, Ilja de Man, Amy Matser, Lizenka van der Meij, Marleen van Polanen, Maria Oud, Clark Reid, Leeann Storey, Marc van Wijk, Joost van den Aardweg, Joyce van Assem, Marijne van Beek, Thyra Blankert, Maartje Dijkstra, Orlane Figaroa, Leah Frenkel, Marit van Gils, Jelle van Haga, Xiaochuan Alvin Han, Agnes Harskamp-Holwerda, Mette Hazenberg, Soemeja Hidad, Nina de Jong, Neeltje Kootstra, Lara Kuijt, Colin Russell, Karlijn van der Straten, Annelou van der Veen, Bas Verkaik, Gerben-Rienk Visser

Distinct implications of body mass index in different subgroups of nonobese patients with heart failure with preserved ejection fraction: a latent class analysis of data from the TOPCAT trial

Bin Dong, Yiling Yao, Ruicong Xue, Weihao Liang, Jiangui He, Fangfei Wei, Yugang Dong, Xin He, Chen Liu

Lower gestational age is associated with lower cortical volume and cognitive and educational performance in adolescence

Qing Ma, Hui Wang, Edmund T. Rolls, Shitong Xiang, Jiong Li, Yuzhu Li, Qiongjie Zhou, Wei Cheng, Fei Li

Comparison between immunotherapy efficacy in early non-small cell lung cancer and advanced non-small cell lung cancer: a systematic review

Yimin Wang, Chuling Li, Zimu Wang, Zhaofeng Wang, Ranpu Wu, Ying Wu, Yong Song, Hongbing Liu

Preparing for pandemics: a systematic review of pandemic influenza clinical management guidelines

Ishmeala Rigby, Melina Michelen, Vincent Cheng, Andrew Dagens, Dania Dahmash, Samuel Lipworth, Eli Harriss, Erhui Cai, Valeria Balan, Alexandra Oti, Reena Joseph, Helen Groves, Peter Hart, Shevin Jacob, Lucille Blumberg, Peter W. Horby, Louise Sigfrid

Lower transmissibility of SARS-CoV-2 among asymptomatic cases: evidence from contact tracing data in Oslo, Norway

Fredrik Methi, Elisabeth Henie Madslien

Childhood diabetes mellitus and early-onset kidney diseases later in life: a nationwide population-based matched cohort study

Jiahong Sun, Ce Wang, Min Zhao, Priscilla M. Y. Lee, Bo Xi, Yongfu Yu, Jiong Li

Exercise training attenuates pulmonary inflammation and mitochondrial dysfunction in a mouse model of high-fat high-carbohydrate-induced NAFLD

Jinkyung Cho, Bruce D. Johnson, Kymberly D. Watt, Alexander S. Niven, Dongwook Yeo, Chul-Ho Kim

Plant-based dietary patterns defined by a priori indices and colorectal cancer risk by sex and race/ethnicity: the Multiethnic Cohort Study

Jihye Kim, Carol J. Boushey, Lynne R. Wilkens, Christopher A. Haiman, Loïc Le Marchand, Song-Yi Park

Vicarious trauma on the hemodialysis healthcare workers in the besieged Ethiopia’s Tigray region: a call to action

Ephrem Berhe, Bisrat Tesfay, Hale Teka

Inequalities in the impact of COVID-19-associated disruptions on tuberculosis diagnosis by age and sex in 45 high TB burden countries

C. Finn McQuaid, Marc Y. R. Henrion, Rachael M. Burke, Peter MacPherson, Rebecca Nzawa-Soko, Katherine C. Horton

Rapid elimination of cervical cancer while maintaining the harms and benefits ratio of cervical cancer screening: a modelling study

Erik E. L. Jansen, Inge M. C. M. de Kok, Sylvia Kaljouw, Erhan Demirel, Harry J. de Koning, Jan. A. C. Hontelez

Turning the tide towards cardiovascular prevention

The transfer of maternal antibodies and dynamics of maternal and natural infection-induced antibodies against coxsackievirus A16 in Chinese children 0–13 years of age: a longitudinal cohort study

Jiaxin Zhou, Yonghong Zhou, Kaiwei Luo, Qiaohong Liao, Wen Zheng, Hui Gong, Huilin Shi, Shanlu Zhao, Kai Wang, Qi Qiu, Bingbing Dai, Lingshuang Ren, Lili Wang, Lidong Gao, Meng Xu, Nuolan Liu, Wanying Lu, Nan Zheng, Xinhua Chen, Zhiyuan Chen, Juan Yang, Simon Cauchemez, Hongjie Yu

Optimized dose selective HDAC inhibitor tucidinostat overcomes anti-PD-L1 antibody resistance in experimental solid tumors

Pei Zhang, Yang Du, Hua Bai, Zhijie Wang, Jianchun Duan, Xin Wang, Jia Zhong, Rui Wan, Jiachen Xu, Xiran He, Di Wang, Kailun Fei, Ruofei Yu, Jie Tian, Jie Wang

Sequential gene expression analysis of cervical malignant transformation identifies RFC4 as a novel diagnostic and prognostic biomarker

Jianwei Zhang, Silu Meng, Xiaoyan Wang, Jun Wang, Xinran Fan, Haiying Sun, Ruoqi Ning, Bing Xiao, Xiangqin Li, Yao Jia, Dongli Kong, Ruqi Chen, Changyu Wang, Ding Ma, Shuang Li

How often do cancer researchers make their data and code available and what factors are associated with sharing?

Daniel G. Hamilton, Matthew J. Page, Sue Finch, Sarah Everitt, Fiona Fidler

Proguanil and atovaquone use is associated with lower colorectal cancer risk: a nationwide cohort study

Naiqi Zhang, Jan Sundquist, Kristina Sundquist, Jianguang Ji

Intestinal gluconeogenesis is downregulated in pediatric patients with celiac disease

Olof Karlson, Henrik Arnell, Audur H. Gudjonsdottir, Daniel Agardh, Åsa Torinsson Naluai

Optimal target of LDL cholesterol level for statin treatment: challenges to monotonic relationship with cardiovascular events

Masashi Sakuma, Satoshi Iimuro, Tomohiro Shinozaki, Takeshi Kimura, Yoshihisa Nakagawa, Yukio Ozaki, Hiroshi Iwata, Katsumi Miyauchi, Hiroyuki Daida, Satoru Suwa, Ichiro Sakuma, Yosuke Nishihata, Yasushi Saito, Hisao Ogawa, Masunori Matsuzaki, Yasuo Ohashi, Isao Taguchi, Shigeru Toyoda, Teruo Inoue, Ryozo Nagai

Assessing the feasibility of sustaining SARS-CoV-2 local containment in China in the era of highly transmissible variants

Yan Wang, Kaiyuan Sun, Zhaomin Feng, Lan Yi, Yanpeng Wu, Hengcong Liu, Quanyi Wang, Marco Ajelli, Cécile Viboud, Hongjie Yu

Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

Pengsheng Li, Haiyan Wang, Lan Guo, Xiaoyan Gou, Gengdong Chen, Dongxin Lin, Dazhi Fan, Xiaoling Guo, Zhengping Liu

Risk for newly diagnosed diabetes after COVID-19: a systematic review and meta-analysis

Ting Zhang, Qimin Mei, Zhaocai Zhang, Joseph Harold Walline, Yecheng Liu, Huadong Zhu, Shuyang Zhang

Prednisolone does not improve olfactory function after COVID-19: a randomized, double-blind, placebo-controlled trial

Emma J. A. Schepens, Esther E. Blijleven, Wilbert M. Boek, Sanne Boesveldt, Robert J. Stokroos, Inge Stegeman, Digna M. A. Kamalski

Longitudinal risk of maternal hospitalization for mental illness following preterm birth

Gabriel Côté-Corriveau, Gilles Paradis, Thuy Mai Luu, Aimina Ayoub, Marianne Bilodeau-Bertrand, Nathalie Auger

Longitudinal evolution of motor and non-motor symptoms in early-stage multiple system atrophy: a 2-year prospective cohort study

Lingyu Zhang, Yanbing Hou, Bei Cao, Qianqian Wei, Ruwei Ou, Kuncheng Liu, Junyu Lin, Tianmi Yang, Yi Xiao, Yongping Chen, Wei Song, Bi Zhao, Huifang Shang

Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs

Dancan M. Wakoli, Bartholomew N. Ondigo, Douglas O. Ochora, Joseph G. Amwoma, Winnie Okore, Edwin W. Mwakio, Gladys Chemwor, Jackeline Juma, Raphael Okoth, Charles Okudo, Redemptah Yeda, Benjamin H. Opot, Agnes C. Cheruiyot, Dennis Juma, Amanda Roth, Benhards R. Ogutu, Daniel Boudreaux, Ben Andagalu, Hoseah M. Akala

Consumption of coffee and tea with all-cause and cause-specific mortality: a prospective cohort study

Yanchun Chen, Yuan Zhang, Mengnan Zhang, Hongxi Yang, Yaogang Wang

Plasma metabolomic profiling of dietary patterns associated with glucose metabolism status: The Maastricht Study

Evan Yi-Wen Yu, Zhewen Ren, Siamak Mehrkanoon, Coen D. A. Stehouwer, Marleen M. J. van Greevenbroek, Simone J. P. M. Eussen, Maurice P. Zeegers, Anke Wesselius

Identifying susceptibility of children and adolescents to the Omicron variant (B.1.1.529)

June Young Chun, Hwichang Jeong, Yongdai Kim

Economic evaluation of COVID-19 rapid antigen screening programs in the workplace

Thomas N. Vilches, Ellen Rafferty, Chad R. Wells, Alison P. Galvani, Seyed M. Moghadas

Interactions among maternal smoking, breastfeeding, and offspring genetic factors on the risk of adult-onset hypertension

Jingjia Liang, Zuqiang Fu, Qian Liu, Yuehong Shen, Xin Zhang, Zhenkun Weng, Jin Xu, Wenxiang Li, Cheng Xu, Yong Zhou, Aihua Gu

Conteltinib (CT-707) in patients with advanced ALK-positive non-small cell lung cancer: a multicenter, open-label, first-in-human phase 1 study

Puyuan Xing, Qian Zhao, Li Zhang, Hanping Wang, Dingzhi Huang, Pei Hu, Yinghui Sun, Yuankai Shi

Health effects of milk consumption: phenome-wide Mendelian randomization study

Shuai Yuan, Jing Sun, Ying Lu, Fengzhe Xu, Doudou Li, Fangyuan Jiang, Zhongxiao Wan, Xue Li, Li-Qiang Qin, Susanna C. Larsson

Prognostic models for COVID-19 needed updating to warrant transportability over time and space

David van Klaveren, Theodoros P. Zanos, Jason Nelson, Todd J. Levy, Jinny G. Park, Isabel R. A. Retel Helmrich, Judith A. C. Rietjens, Melissa J. Basile, Negin Hajizadeh, Hester F. Lingsma, David M. Kent

Identifying and ranking causal biochemical biomarkers for breast cancer: a Mendelian randomisation study

Sonja N. Tang, Verena Zuber, Konstantinos K. Tsilidis

Noninvasive detection of pancreatic ductal adenocarcinoma using the methylation signature of circulating tumour DNA

Huanwen Wu, Shiwei Guo, Xiaoding Liu, Yatong Li, Zhixi Su, Qiye He, Xiaoqian Liu, Zhiwen Zhang, Lianyuan Yu, Xiaohan Shi, Suizhi Gao, Huan Wang, Yaqi Pan, Chengcheng Ma, Rui Liu, Menghua Dai, Gang Jin, Zhiyong Liang

Implementation and delivery of group consultations for young people with diabetes in socioeconomically deprived, ethnically diverse settings

Chrysanthi Papoutsi, Dougal Hargreaves, Ann Hagell, Natalia Hounsome, Helen Skirrow, Koteshwara Muralidhara, Grainne Colligan, Anne Ferrey, Shanti Vijayaraghavan, Trish Greenhalgh, Sarah Finer

Prevalence and trend of smokeless tobacco use and its associated factors among adolescents aged 12–16 years in 138 countries/territories, 1999–2019

Hui Yang, Chuanwei Ma, Min Zhao, Costan G. Magnussen, Bo Xi

Risk factors affecting COVID-19 vaccine effectiveness identified from 290 cross-country observational studies until February 2022: a meta-analysis and meta-regression

Marek Petráš, Roman Máčalík, Daniela Janovská, Alexander M. Čelko, Jana Dáňová, Eliška Selinger, Jonáš Doleček, Sylva Neradová, Martina Franklová, Pavel Dlouhý, Jozef Rosina, Ivana Králová Lesná

Interim analysis from a phase 2 randomized trial of EuCorVac-19: a recombinant protein SARS-CoV-2 RBD nanoliposome vaccine

Jonathan F. Lovell, Yeong Ok Baik, Seuk Keun Choi, Chankyu Lee, Jeong-Yoon Lee, Kazutoyo Miura, Wei-Chiao Huang, Young-Shin Park, Sun-Je Woo, Sang Hwan Seo, Jae-Ouk Kim, Manki Song, Chung-Jong Kim, Jae-Ki Choi, Jieun Kim, Eun Ju Choo, Jung-Hyun Choi

A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension

Xiao Xiao, Rui Li, Cunjin Wu, Yupeng Yan, Mengmeng Yuan, Bing Cui, Yu Zhang, Channa Zhang, Xiaoxia Zhang, Weili Zhang, Rutai Hui, Yibo Wang

Bidirectional genetic overlap between bipolar disorder and intelligence

Meng-Yuan Shang, Yong Wu, Chu-Yi Zhang, Hao-Xiang Qi, Qing Zhang, Jin-Hua Huo, Lu Wang, Chuang Wang, Ming Li

Predictive model for long COVID in children 3 months after a SARS-CoV-2 PCR test

Manjula D. Nugawela, Terence Stephenson, Roz Shafran, Bianca L. De Stavola, Shamez N. Ladhani, Ruth Simmons, Kelsey McOwat, Natalia Rojas, Emma Dalrymple, Emily Y. Cheung, Tamsin Ford, Isobel Heyman, Esther Crawley, Snehal M. Pinto Pereira

Retinal age gap as a predictive biomarker of stroke risk

Zhuoting Zhu, Wenyi Hu, Ruiye Chen, Ruilin Xiong, Wei Wang, Xianwen Shang, Yifan Chen, Katerina Kiburg, Danli Shi, Shuang He, Yu Huang, Xueli Zhang, Shulin Tang, Jieshan Zeng, Honghua Yu, Xiaohong Yang, Mingguang He

Spatiotemporal trends and ecological determinants of cardiovascular mortality among 2844 counties in mainland China, 2006–2020: a Bayesian modeling study of national mortality registries

Wei Wang, Junming Li, Yunning Liu, Pengpeng Ye, Chengdong Xu, Peng Yin, Jiangmei Liu, Jinlei Qi, Jinling You, Lin Lin, Ziwei Song, Limin Wang, Lijun Wang, Yong Huo, Maigeng Zhou

Short stature and language development in the United Kingdom: a longitudinal analysis of children from the Millennium Cohort Study

Joseph Freer, Joanna Orr, Joan K. Morris, Robert Walton, Leo Dunkel, Helen L. Storr, Andrew J. Prendergast

A digital application and augmented physician rounds reduce postoperative pain and opioid consumption after primary total knee replacement (TKR): a randomized clinical trial

Julia Stuhlreyer, Christian Roder, Florian Krug, Christian Zöllner, Herta Flor, Regine Klinger

Tumor PKCδ instigates immune exclusion in EGFR-mutated non–small cell lung cancer

Yi-Han Zuo, Wei-Na Gao, Ya-Jia Xie, Sheng-Yong Yang, Jin-Tai Zhou, Hai-Hai Liang, Xing-Xing Fan

Genomic epidemiology of Escherichia coli: antimicrobial resistance through a One Health lens in sympatric humans, livestock and peri-domestic wildlife in Nairobi, Kenya

Dishon M. Muloi, James M. Hassell, Bryan A. Wee, Melissa J. Ward, Judy M. Bettridge, Velma Kivali, Alice Kiyong’a, Christine Ndinda, Nduhiu Gitahi, Tom Ouko, Titus Imboma, James Akoko, Maurice K. Murungi, Samuel M. Njoroge, Patrick Muinde, Lorren Alumasa, Titus Kaitho, Fredrick Amanya, Allan Ogendo, Bram A. D. van Bunnik, John Kiiru, Timothy P. Robinson, Erastus K. Kang’ethe, Samuel Kariuki, Amy B. Pedersen, Eric M. Fèvre, Mark E. J. Woolhouse

A multi-center, single-arm, phase II study of anlotinib plus paclitaxel and cisplatin as the first-line therapy of recurrent/advanced esophageal squamous cell carcinoma

Ning Li, Tao Wu, Yong-Gui Hong, Yan-Zhen Guo, Yu-Feng Cheng, Yi-Jie Ma, Liang-Yu Bie, Dong-Hai Cui, Xiao-Hui Gao, Bing-Xu Tan, Bao-Sheng Li, Su-Xia Luo, Jun-Sheng Wang

Frailty and risk of microvascular complications in patients with type 2 diabetes: a population-based cohort study

Yuanjue Wu, Ting Xiong, Xiao Tan, Liangkai Chen

Identifying novel proteins underlying schizophrenia via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data

Xiaojing Gu, Meng Dou, Weiming Su, Zheng Jiang, Qingqing Duan, Bei Cao, Yongping Chen

A novel 450-nm laser-mediated sinoporphyrin sodium-based photodynamic therapy induces autophagic cell death in gastric cancer through regulation of the ROS/PI3K/Akt/mTOR signaling pathway

Xing Li, Lijiang Gu, Yuhang Chen, Xiaobing Wang, Yibo Mei, Jinlai Zhou, Minghai Ma, Jianbin Ma, Yue Chong, Xinyang Wang, Peng Guo, Dalin He, Jin Zeng

Correction: Modified cardiovascular SOFA score in sepsis: development and internal and external validation

Hui Jai Lee, Byuk Sung Ko, Seung Mok Ryoo, Eunah Han, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Tae Ho Lim, Won Young Kim, Woon Yong Kwon, Sung Yeon Hwang, You Hwan Jo, Jonghwan Shin, Tae Gun Shin, Kyuseok Kim

Correction: A multicenter, double-blind, randomized, parallel-group, placebo-controlled study to evaluate the efficacy and safety of camostat mesilate in patients with COVID-19 (CANDLE study)

Taku Kinoshita, Masahiro Shinoda, Yasuhiro Nishizaki, Katsuya Shiraki, Yuji Hirai, Yoshiko Kichikawa, Kenji Tsushima, Masaharu Shinkai, Naoyuki Komura, Kazuo Yoshida, Yasutoshi Kido, Hiroshi Kakeya, Naoto Uemura, Junichi Kadota

Links between electroconvulsive therapy responsive and cognitive impairment multimodal brain networks in late-life major depressive disorder

Shile Qi, Vince D. Calhoun, Daoqiang Zhang, Jeremy Miller, Zhi-De Deng, Katherine L. Narr, Yvette Sheline, Shawn M. McClintock, Rongtao Jiang, Xiao Yang, Joel Upston, Tom Jones, Jing Sui, Christopher C. Abbott

Clinical staging and the differential risks for clinical and functional outcomes in young people presenting for youth mental health care

William Capon, Ian B. Hickie, Mathew Varidel, Ante Prodan, Jacob J. Crouse, Joanne S. Carpenter, Shane P. Cross, Alissa Nichles, Natalia Zmicerevska, Adam J. Guastella, Elizabeth M. Scott, Jan Scott, Jai Shah, Frank Iorfino

Potential clinical utility of liquid biopsy in early-stage non-small cell lung cancer

Haifeng Shen, Yichen Jin, Heng Zhao, Manqi Wu, Kai Zhang, Zihan Wei, Xin Wang, Ziyang Wang, Yun Li, Fan Yang, Jun Wang, Kezhong Chen

An electrochemical nitric oxide generator for in-home inhalation therapy in pulmonary artery hypertension

Yiwei Liu, Yifan Zhu, Chenyu Jiang, Zhanhao Su, Yi Yan, Bei Feng, Wen Mao, Yuyan Zhang, Xiaojian Wang, Zhuoming Xu, Hao Zhang

Use of hormonal contraceptives and antidepressants and risks of suicidal behavior and accidents among women with premenstrual disorders: a nationwide cohort study

Qian Yang, Tyra Lagerberg, Arvid Sjölander, Elizabeth R. Bertone-Johnson, Fang Fang, Weimin Ye, Zheng Chang, Unnur A. Valdimarsdóttir, Donghao Lu

Clinicopathologic features and abnormal signaling pathways in plasmablastic lymphoma: a multicenter study in China

Di Shi, Lin Gao, Xiao-Chun Wan, Jin Li, Tian Tian, Jue Hu, Qun-Ling Zhang, Yi-Fan Su, Yu-Peng Zeng, Zi-Juan Hu, Bao-Hua Yu, Xiao-Qiu Li, Ping Wei, Ji-Wei Li, Xiao-Yan Zhou

Association of shift work with incident dementia: a community-based cohort study

Huanquan Liao, Dong Pan, Zhenhong Deng, Jingru Jiang, Jinhua Cai, Ying Liu, Baixuan He, Ming Lei, Honghong Li, Yi Li, Yongteng Xu, Yamei Tang

Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study

Marwah Doestzada, Daria V. Zhernakova, Inge C. L. van den Munckhof, Daoming Wang, Alexander Kurilshikov, Lianmin Chen, Vincent W. Bloks, Martijn van Faassen, Joost H. W. Rutten, Leo A. B. Joosten, Mihai G. Netea, Cisca Wijmenga, Niels P. Riksen, Alexandra Zhernakova, Folkert Kuipers, Jingyuan Fu

Frequency of adding salt at the table and risk of incident cardiovascular disease and all-cause mortality: a prospective cohort study

Fengping Li, Liangkai Chen, Buyun Liu, Victor W. Zhong, Yan Deng, Dan Luo, Chao Gao, Wei Bao, Shuang Rong

Effect of sacubitril/valsartan and ACEI/ARB on glycaemia and the development of diabetes: a systematic review and meta-analysis of randomised controlled trials

Ruxin Wang, Haowen Ye, Yongting Zhao, Jinjing Wei, Ying Wang, Xiaofang Zhang, Lihong Wang

Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000–2018

Emily Haeuser, Audrey L. Serfes, Michael A. Cork, Mingyou Yang, Hedayat Abbastabar, E. S. Abhilash, Maryam Adabi, Oladimeji M. Adebayo, Victor Adekanmbi, Daniel Adedayo Adeyinka, Saira Afzal, Bright Opoku Ahinkorah, Keivan Ahmadi, Muktar Beshir Ahmed, Yonas Akalu, Rufus Olusola Akinyemi, Chisom Joyqueenet Akunna, Fares Alahdab, Fahad Mashhour Alanezi, Turki M. Alanzi, Kefyalew Addis Alene, Robert Kaba Alhassan, Vahid Alipour, Amir Almasi-Hashiani, Nelson Alvis-Guzman, Edward Kwabena Ameyaw, Saeed Amini, Dickson A. Amugsi, Robert Ancuceanu, Davood Anvari, Seth Christopher Yaw Appiah, Jalal Arabloo, Olatunde Aremu, Mulusew A. Asemahagn, Mohammad Asghari Jafarabadi, Atalel Fentahun Awedew, Beatriz Paulina Ayala Quintanilla, Martin Amogre Ayanore, Yared Asmare Aynalem, Samad Azari, Zelalem Nigussie Azene, B. B. Darshan, Tesleem Kayode Babalola, Atif Amin Baig, Maciej Banach, Till Winfried Bärnighausen, Arielle Wilder Bell, Akshaya Srikanth Bhagavathula, Nikha Bhardwaj, Pankaj Bhardwaj, Krittika Bhattacharyya, Ali Bijani, Zebenay Workneh Bitew, Somayeh Bohlouli, Obasanjo Afolabi Bolarinwa, Archith Boloor, Ivana Bozicevic, Zahid A. Butt, Rosario Cárdenas, Felix Carvalho, Jaykaran Charan, Vijay Kumar Chattu, Mohiuddin Ahsanul Kabir Chowdhury, Dinh-Toi Chu, Richard G. Cowden, Saad M. A. Dahlawi, Giovanni Damiani, Eugene Kofuor Maafo Darteh, Aso Mohammad Darwesh, José das Neves, Nicole Davis Weaver, Diego De Leo, Jan-Walter De Neve, Kebede Deribe, Keshab Deuba, Samath Dharmaratne, Mostafa Dianatinasab, Daniel Diaz, Alireza Didarloo, Shirin Djalalinia, Fariba Dorostkar, Eleonora Dubljanin, Bereket Duko, Maha El Tantawi, Shaimaa I. El-Jaafary, Babak Eshrati, Sharareh Eskandarieh, Oghenowede Eyawo, Ifeanyi Jude Ezeonwumelu, Sayeh Ezzikouri, Farshad Farzadfar, Nazir Fattahi, Nelsensius Klau Fauk, Eduarda Fernandes, Irina Filip, Florian Fischer, Nataliya A. Foigt, Masoud Foroutan, Takeshi Fukumoto, Mohamed M. Gad, Abhay Motiramji Gaidhane, Birhan Gebresillassie Gebregiorgis, Ketema Bizuwork Gebremedhin, Lemma Getacher, Keyghobad Ghadiri, Ahmad Ghashghaee, Mahaveer Golechha, Mohammed Ibrahim Mohialdeen Gubari, Harish Chander Gugnani, Rafael Alves Guimarães, Mohammad Rifat Haider, Arvin Haj-Mirzaian, Samer Hamidi, Abdiwahab Hashi, Soheil Hassanipour, Hadi Hassankhani, Khezar Hayat, Claudiu Herteliu, Hung Chak Ho, Ramesh Holla, Mostafa Hosseini, Mehdi Hosseinzadeh, Bing-Fang Hwang, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Irena M. Ilic, Milena D. Ilic, Rakibul M. Islam, Chidozie C. D. Iwu, Mihajlo Jakovljevic, Ravi Prakash Jha, John S. Ji, Kimberly B. Johnson, Nitin Joseph, Vasna Joshua, Farahnaz Joukar, Jacek Jerzy Jozwiak, Leila R. Kalankesh, Rohollah Kalhor, Naser Kamyari, Tanuj Kanchan, Behzad Karami Matin, Salah Eddin Karimi, Gbenga A. Kayode, Ali Kazemi Karyani, Maryam Keramati, Ejaz Ahmad Khan, Gulfaraz Khan, Md Nuruzzaman Khan, Khaled Khatab, Jagdish Khubchandani, Yun Jin Kim, Adnan Kisa, Sezer Kisa, Jacek A. Kopec, Soewarta Kosen, Sindhura Lakshmi Koulmane Laxminarayana, Ai Koyanagi, Kewal Krishan, Barthelemy Kuate Defo, Nuworza Kugbey, Vaman Kulkarni, Manasi Kumar, Nithin Kumar, Dian Kusuma, Carlo La Vecchia, Dharmesh Kumar Lal, Iván Landires, Heidi Jane Larson, Savita Lasrado, Paul H. Lee, Shanshan Li, Xuefeng Liu, Afshin Maleki, Preeti Malik, Mohammad Ali Mansournia, Francisco Rogerlândio Martins-Melo, Walter Mendoza, Ritesh G. Menezes, Endalkachew Worku Mengesha, Tuomo J. Meretoja, Tomislav Mestrovic, Andreea Mirica, Babak Moazen, Osama Mohamad, Yousef Mohammad, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Salahuddin Mohammed, Shafiu Mohammed, Ali H. Mokdad, Masoud Moradi, Paula Moraga, Sumaira Mubarik, Getaneh Baye B. Mulu, Lillian Mwanri, Ahamarshan Jayaraman Nagarajan, Mukhammad David Naimzada, Muhammad Naveed, Javad Nazari, Rawlance Ndejjo, Ionut Negoi, Frida N. Ngalesoni, Georges Nguefack-Tsague, Josephine W. Ngunjiri, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Chukwudi A. Nnaji, Jean Jacques Noubiap, Virginia Nuñez-Samudio, Vincent Ebuka Nwatah, Bogdan Oancea, Oluwakemi Ololade Odukoya, Andrew T. Olagunju, Babayemi Oluwaseun Olakunde, Bolajoko Olubukunola Olusanya, Jacob Olusegun Olusanya, Ahmed Omar Bali, Obinna E. Onwujekwe, Orish Ebere Orisakwe, Nikita Otstavnov, Stanislav S. Otstavnov, Mayowa O. Owolabi, P. A. Mahesh, Jagadish Rao Padubidri, Adrian Pana, Ashok Pandey, Seithikurippu R. Pandi-Perumal, Fatemeh Pashazadeh Kan, George C. Patton, Shrikant Pawar, Emmanuel K. Peprah, Maarten J. Postma, Liliana Preotescu, Zahiruddin Quazi Syed, Navid Rabiee, Amir Radfar, Alireza Rafiei, Fakher Rahim, Vafa Rahimi-Movaghar, Amir Masoud Rahmani, Kiana Ramezanzadeh, Juwel Rana, Chhabi Lal Ranabhat, Sowmya J. Rao, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Lemma Demissie Regassa, Nima Rezaei, Aziz Rezapour, Mavra A. Riaz, Ana Isabel Ribeiro, Jennifer M. Ross, Enrico Rubagotti, Susan Fred Rumisha, Godfrey M. Rwegerera, Sahar Saeedi Moghaddam, Rajesh Sagar, Biniyam Sahiledengle, Maitreyi Sahu, Marwa Rashad Salem, Hossein Samadi Kafil, Abdallah M. Samy, Benn Sartorius, Brijesh Sathian, Abdul-Aziz Seidu, Amira A. Shaheen, Masood Ali Shaikh, Morteza Shamsizadeh, Wondimeneh Shibabaw Shiferaw, Jae Il Shin, Roman Shrestha, Jasvinder A. Singh, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Shahin Soltani, Mu’awiyyah Babale Sufiyan, Takahiro Tabuchi, Eyayou Girma Tadesse, Nuno Taveira, Fisaha Haile Tesfay, Rekha Thapar, Marcos Roberto Tovani-Palone, Gebiyaw Wudie Tsegaye, Chukwuma David Umeokonkwo, Bhaskaran Unnikrishnan, Jorge Hugo Villafañe, Francesco S. Violante, Bay Vo, Giang Thu Vu, Yohannes Dibaba Wado, Yasir Waheed, Richard G. Wamai, Yanzhong Wang, Paul Ward, Nuwan Darshana Wickramasinghe, Katherine Wilson, Sanni Yaya, Paul Yip, Naohiro Yonemoto, Chuanhua Yu, Mikhail Sergeevich Zastrozhin, Yunquan Zhang, Zhi-Jiang Zhang, Simon I. Hay, Laura Dwyer-Lindgren

Contraceptive use and contraceptive counselling interventions for women of reproductive age with cancer: a systematic review and meta-analysis

Melissa L. Harris, Tesfaye R. Feyissa, Nikola A. Bowden, Kristina Gemzell-Danielsson, Deborah Loxton

Early emergence of sexual dimorphism in offspring leukocyte telomere length was associated with maternal and children’s glucose metabolism—a longitudinal study

Kwun Kiu Wong, Feifei Cheng, Cadmon K. P. Lim, Claudia H. T. Tam, Greg Tutino, Lai Yuk Yuen, Chi Chiu Wang, Yong Hou, Michael H. M. Chan, Chung Shun Ho, Mugdha V. Joglekar, Anandwardhan A. Hardikar, Alicia J. Jenkins, Boyd E. Metzger, William L. Lowe Jr., Wing Hung Tam, Ronald C. W. Ma

Correction: A genome-wide association study identifies a novel association between SDC3 and apparent treatment-resistant hypertension

Xiao Xiao, Rui Li, Cunjin Wu, Yupeng Yan, Mengmeng Yuan, Bing Cui, Yu Zhang, Channa Zhang, Xiaoxia Zhang, Weili Zhang, Rutai Hui, Yibo Wang

Population-based cohort study: proton pump inhibitor use during pregnancy in Sweden and the risk of maternal and neonatal adverse events

Esmee M. Breddels, Johanna Simin, Romina Fornes, Helene Lilja Engstrand, Lars Engstrand, Robin Bruyndonckx, Nele Brusselaers

Safety and effectiveness of neoadjuvant PD-1 inhibitor (toripalimab) plus chemotherapy in stage II–III NSCLC (LungMate 002): an open-label, single-arm, phase 2 trial

Xinsheng Zhu, Liangdong Sun, Nan Song, Wenxin He, Boxiong Xie, Junjie Hu, Jing Zhang, Jie Yang, Jie Dai, Dongliang Bian, Haoran Xia, Fenghuan Sun, Anwen Xiong, Jie Luo, Lele Zhang, Huansha Yu, Ming Liu, Hongcheng Liu, Haifeng Wang, Haiping Zhang, Chang Chen, Chunyan Wu, Liang Duan, Yuming Zhu, Peng Zhang, Gening Jiang

Obese visceral fat tissue inflammation: from protective to detrimental?

Hubert Kolb

Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders

P. Auvinen, J. Vehviläinen, H. Marjonen, V. Modhukur, J. Sokka, E. Wallén, K. Rämö, L. Ahola, A. Salumets, T. Otonkoski, H. Skottman, M. Ollikainen, R. Trokovic, H. Kahila, N. Kaminen-Ahola

Diastolic dysfunction and sex-specific progression to HFpEF: current gaps in knowledge and future directions

A. M. L. N. van Ommen, E. Dal Canto, Maarten J. Cramer, F. H. Rutten, N. C. Onland-Moret, H. M. den Ruijter

Distinct metabolic biomarkers to distinguish IgG4-related disease from Sjogren’s syndrome and pancreatic cancer and predict disease prognosis

Songxin Yan, Yu Peng, Ziyan Wu, Linlin Cheng, Haolong Li, Honglin Xu, Yuan Huang, Wen Zhang, Yongzhe Li

Neoadjuvant pyrotinib, trastuzumab, and docetaxel for HER2-positive breast cancer (PHEDRA): a double-blind, randomized phase 3 trial

Jiong Wu, Zefei Jiang, Zhenzhen Liu, Benlong Yang, Hongjian Yang, Jinhai Tang, Kun Wang, Yunjiang Liu, Haibo Wang, Peifen Fu, Shuqun Zhang, Qiang Liu, Shusen Wang, Jian Huang, Chuan Wang, Shu Wang, Yongsheng Wang, Linlin Zhen, Xiaoyu Zhu, Fei Wu, Xiang Lin, Jianjun Zou

Ethical and regulatory issues of stem cell-derived 3-dimensional organoid and tissue therapy for personalised regenerative medicine

Alexander R. Harris, Mary Jean Walker, Frederic Gilbert

Multi-omics gut microbiome signatures in obese women: role of diet and uncontrolled eating behavior

Monica Barone, Silvia Garelli, Simone Rampelli, Alessandro Agostini, Silke Matysik, Federica D’Amico, Sabrina Krautbauer, Roberta Mazza, Nicola Salituro, Flaminia Fanelli, Patricia Iozzo, Yolanda Sanz, Marco Candela, Patrizia Brigidi, Uberto Pagotto, Silvia Turroni