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Zeitschrift

BMC Medicine 1/2022
BMC Medicine

Ausgabe 1/2022

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Inhaltsverzeichnis (216 Artikel)

Open Access 01.12.2022 | Research article

Exploring the causal role of intimate partner violence and abuse on depressive symptoms in young adults: a population-based cohort study
Annie Herbert, Jon Heron, Maria Barnes, Christine Barter, Gene Feder, Khadija Meghrawi, Eszter Szilassy, Abigail Fraser, Laura D. Howe

Open Access 01.12.2022 | Research article

Predictors of cardio-kidney complications and treatment failure in patients with chronic kidney disease and type 2 diabetes treated with SGLT2 inhibitors
Csaba Kovesdy, Niklas Schmedt, Kerstin Folkerts, Kevin Bowrin, Hanaya Raad, Michael Batech, Linda Fried

Open Access 01.12.2022 | Research article

Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis
Emmanouil Bouras, Ville Karhunen, Dipender Gill, Jian Huang, Philip C. Haycock, Marc J. Gunter, Mattias Johansson, Paul Brennan, Tim Key, Sarah J. Lewis, Richard M. Martin, Neil Murphy, Elizabeth A. Platz, Ruth Travis, James Yarmolinsky, Verena Zuber, Paul Martin, Michail Katsoulis, Heinz Freisling, Therese Haugdahl Nøst, Matthias B. Schulze, Laure Dossus, Rayjean J. Hung, Christopher I. Amos, Ari Ahola-Olli, Saranya Palaniswamy, Minna Männikkö, Juha Auvinen, Karl-Heinz Herzig, Sirkka Keinänen-Kiukaanniemi, Terho Lehtimäki, Veikko Salomaa, Olli Raitakari, Marko Salmi, Sirpa Jalkanen, Marjo-Riitta Jarvelin, Abbas Dehghan, Konstantinos K. Tsilidis, The PRACTICAL consortium

Open Access 01.12.2022 | Research article

Maternal cigarette smoking before or during pregnancy increases the risk of birth congenital anomalies: a population-based retrospective cohort study of 12 million mother-infant pairs
Lili Yang, Huan Wang, Liu Yang, Min Zhao, Yajun Guo, Pascal Bovet, Bo Xi

Open Access 01.12.2022 | Research article

Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank
Hassan S. Dashti, Nicole Miranda, Brian E. Cade, Tianyi Huang, Susan Redline, Elizabeth W. Karlson, Richa Saxena

Open Access 01.12.2022 | Research article

Variety and quantity of dietary protein intake from different sources and risk of new-onset diabetes: a Nationwide Cohort Study in China
Chun Zhou, Chengzhang Liu, Zhuxian Zhang, Mengyi Liu, Yuanyuan Zhang, Huan Li, Panpan He, Qinqin Li, Xianhui Qin

Open Access 01.12.2022 | Research article

Ultra-processed food and incident type 2 diabetes: studying the underlying consumption patterns to unravel the health effects of this heterogeneous food category in the prospective Lifelines cohort
Ming-Jie Duan, Petra C. Vinke, Gerjan Navis, Eva Corpeleijn, Louise H. Dekker

Open Access 01.12.2022 | Research article

Cell-free DNA methylation markers for differential diagnosis of hepatocellular carcinoma
Biyuan Luo, Fang Ma, Hao Liu, Jixiong Hu, Le Rao, Chun Liu, Yongfang Jiang, Shuyu Kuangzeng, Xuan Lin, Chenyang Wang, Yiyu Lei, Zhongzhou Si, Guangshun Chen, Ning Zhou, Chengbai Liang, Fangqing Jiang, Fenge Liu, Weidong Dai, Wei Liu, Yawen Gao, Zhihong Li, Xi Li, Guangyu Zhou, Bingsi Li, Zhihong Zhang, Weiqi Nian, Lihua Luo, Xianling Liu

Open Access 01.12.2022 | Research article

Rapid intrapartum test for maternal group B streptococcal colonisation and its effect on antibiotic use in labouring women with risk factors for early-onset neonatal infection (GBS2): cluster randomised trial with nested test accuracy study
Jane P. Daniels, Emily Dixon, Alicia Gill, Jon Bishop, Mark Wilks, Michael Millar, Jim Gray, Tracy E. Roberts, Jane Plumb, Jonathan J. Deeks, Karla Hemming, Khalid S. Khan, Shakila Thangaratinam, on behalf of the GBS2 Collaborative Group

Open Access 01.12.2022 | Research article

Nudging customers towards healthier food and beverage purchases in a real-life online supermarket: a multi-arm randomized controlled trial
Josine M. Stuber, Jeroen Lakerveld, Loes W. Kievitsbosch, Joreintje D. Mackenbach, Joline W. J. Beulens

Open Access 01.12.2022 | Opinion

Short structural variants as informative genetic markers for ALS disease risk and progression
Frances Theunissen, Loren L. Flynn, Ryan S. Anderton, P. Anthony Akkari

Open Access 01.12.2022 | Research article

Intracranial efficacy of alectinib in ALK-positive NSCLC patients with CNS metastases—a multicenter retrospective study
Zihua Zou, Puyuan Xing, Xuezhi Hao, Yan Wang, Xia Song, Li Shan, Cuiying Zhang, Ziling Liu, Kewei Ma, Guilan Dong, Junling Li

Open Access 01.12.2022 | Research article

PCSK9 inhibitor recaticimab for hypercholesterolemia on stable statin dose: a randomized, double-blind, placebo-controlled phase 1b/2 study
Mingtong Xu, Xiaoxue Zhu, Junyan Wu, Yuling Zhang, Dong Zhao, Xuhong Wang, Yanhua Ding, Yu Cao, Chengqian Li, Wei Hu, Jianlong Sheng, Zhu Luo, Zeqi Zheng, Jinfang Hu, Jianying Liu, Xiaoyang Zhou, Aizong Shen, Xiaomei Ding, Yongdong Zhang, Yonggang Zhao, Yijing Li, Sheng Zhong, Shimin An, Jianjun Zou, Li Yan

Open Access 01.12.2022 | Research article

The anti-aging factor Klotho protects against acquired long QT syndrome induced by uremia and promoted by fibroblast growth factor 23
José Alberto Navarro-García, Rafael Salguero-Bodes, Laura González-Lafuente, Laura Martín-Nunes, Elena Rodríguez-Sánchez, Teresa Bada-Bosch, Eduardo Hernández, Evangelina Mérida-Herrero, Manuel Praga, Jorge Solís, Fernando Arribas, Héctor Bueno, Makoto Kuro-O, María Fernández-Velasco, Luis Miguel Ruilope, Carmen Delgado, Gema Ruiz-Hurtado

Open Access 01.12.2022 | Research article

The impact of sex and physical performance on long-term mortality in older patients with myocardial infarction
Elisabetta Tonet, Albert Ariza-Solé, Matteo Serenelli, Francesc Formiga, Juan Sanchis, Rita Pavasini, Pablo Diez-Villanueva, Francesco Vitali, Clara Bonanad, Giovanni Grazzi, Antoni Carol, Giorgio Chiaranda, Graziella Pompei, Laura Sofia Cardelli, Serena Caglioni, Federico Gibiino, Stefano Volpato, Gianluca Campo

Open Access 01.12.2022 | Research article

Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy
Justyna Mączyńska, Florian Raes, Chiara Da Pieve, Stephen Turnock, Jessica K. R. Boult, Julia Hoebart, Marcin Niedbala, Simon P. Robinson, Kevin J. Harrington, Wojciech Kaspera, Gabriela Kramer-Marek

Open Access 01.12.2022 | Research article

The empirical support for the radical cure strategy for eliminating Plasmodium vivax in China
Guo-Jing Yang, Le-Yuan Shang, Xiao-Nong Zhou, Tamsin E. Lee, Bo Bi, Michael White, Thomas A. Smith, Melissa A. Penny

Open Access 01.12.2022 | Research article

Modest alcohol intake and mortality in individuals with elevated alanine aminotransferase levels: a nationwide cohort study
Dong Hyun Sinn, Danbee Kang, Eliseo Guallar, Yun Soo Hong, Juhee Cho, Geum-Youn Gwak

Open Access 01.12.2022 | Research article

Association between hypertensive disorders of pregnancy and later risk of cardiovascular outcomes
Clare Oliver-Williams, David Stevens, Rupert A. Payne, Ian B. Wilkinson, Gordon C. S. Smith, Angela Wood

Open Access 01.12.2022 | Research article

Variability in newborn telomere length is explained by inheritance and intrauterine environment
Li Chen, Karen Mei Ling Tan, Min Gong, Mary F. F. Chong, Kok Hian Tan, Yap Seng Chong, Michael J. Meaney, Peter D. Gluckman, Johan G. Eriksson, Neerja Karnani

Open Access 01.12.2022 | Research article

Identification of heart failure with preserved ejection fraction helps risk stratification for hypertrophic cardiomyopathy
Jie Liu, Dong Wang, Jieyun Ruan, Guixin Wu, Lianjun Xu, Wen Jiang, Jizheng Wang, Xiaolu Sun, Lianming Kang, Lei Song

Open Access 01.12.2022 | Research article

The effect of oral diabetes medications on glycated haemoglobin (HbA1c) in Asians in primary care: a retrospective cohort real-world data study
Hao Sen Andrew Fang, Qiao Gao, Wei Ying Tan, Mong Li Lee, Wynne Hsu, Ngiap Chuan Tan

Open Access 01.12.2022 | Guideline

Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) statement: updated reporting guidance for health economic evaluations
Don Husereau, Michael Drummond, Federico Augustovski, Esther de Bekker-Grob, Andrew H. Briggs, Chris Carswell, Lisa Caulley, Nathorn Chaiyakunapruk, Dan Greenberg, Elizabeth Loder, Josephine Mauskopf, C. Daniel Mullins, Stavros Petrou, Raoh-Fang Pwu, Sophie Staniszewska, on behalf of CHEERS 2022 ISPOR Good Research Practices Task Force

Open Access 01.12.2022 | COVID-19 | Research article

Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients
Zhonghan Sun, Zhi-Gang Song, Chenglin Liu, Shishang Tan, Shuchun Lin, Jiajun Zhu, Fa-Hui Dai, Jian Gao, Jia-Lei She, Zhendong Mei, Tao Lou, Jiao-Jiao Zheng, Yi Liu, Jiang He, Yuanting Zheng, Chen Ding, Feng Qian, Yan Zheng, Yan-Mei Chen

Open Access 01.12.2022 | Research article

Modelling upper respiratory viral load dynamics of SARS-CoV-2
Joseph D. Challenger, Cher Y. Foo, Yue Wu, Ada W. C. Yan, Mahdi Moradi Marjaneh, Felicity Liew, Ryan S. Thwaites, Lucy C. Okell, Aubrey J. Cunnington

Open Access 01.12.2022 | COVID-19 | Research article

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
Feargal J. Ryan, Christopher M. Hope, Makutiro G. Masavuli, Miriam A. Lynn, Zelalem A. Mekonnen, Arthur Eng Lip Yeow, Pablo Garcia-Valtanen, Zahraa Al-Delfi, Jason Gummow, Catherine Ferguson, Stephanie O’Connor, Benjamin A. J. Reddi, Pravin Hissaria, David Shaw, Chuan Kok-Lim, Jonathan M. Gleadle, Michael R. Beard, Simon C. Barry, Branka Grubor-Bauk, David J. Lynn

Open Access 01.12.2022 | Research article

Impact of a school-based health intervention program on body composition among South African primary schoolchildren: results from the KaziAfya cluster-randomized controlled trial
Kurt Z. Long, Johanna Beckmann, Christin Lang, Harald Seelig, Siphesihle Nqweniso, Nicole Probst-Hensch, Ivan Müller, Uwe Pühse, Peter Steinmann, Rosa du Randt, Cheryl Walter, Jürg Utzinger, Markus Gerber

Open Access 01.12.2022 | Research article

Malaria hospitalisation in East Africa: age, phenotype and transmission intensity
Alice Kamau, Robert S. Paton, Samuel Akech, Arthur Mpimbaza, Cynthia Khazenzi, Morris Ogero, Eda Mumo, Victor A. Alegana, Ambrose Agweyu, Neema Mturi, Shebe Mohammed, Godfrey Bigogo, Allan Audi, James Kapisi, Asadu Sserwanga, Jane F. Namuganga, Simon Kariuki, Nancy A. Otieno, Bryan O. Nyawanda, Ally Olotu, Nahya Salim, Thabit Athuman, Salim Abdulla, Amina F. Mohamed, George Mtove, Hugh Reyburn, Sunetra Gupta, José Lourenço, Philip Bejon, Robert W. Snow

Open Access 01.12.2022 | COVID-19 | Research article

Single-dose SARS-CoV-2 vaccinations with either BNT162b2 or AZD1222 induce disparate Th1 responses and IgA production
Michael Müller, Johann Volzke, Behnam Subin, Silke Müller, Martina Sombetzki, Emil C. Reisinger, Brigitte Müller-Hilke

Open Access 01.12.2022 | Research article

Implementation of the Mental Capacity Act: a national observational study comparing resultant trends in place of death for older heart failure decedents with or without comorbid dementia
James M. Beattie, Irene J. Higginson, Theresa A. McDonagh, Wei Gao

Open Access 01.12.2022 | COVID-19 | Research article

Humoral immune response after different SARS-CoV-2 vaccination regimens
Ruben Rose, Franziska Neumann, Olaf Grobe, Thomas Lorentz, Helmut Fickenscher, Andi Krumbholz

Open Access 01.12.2022 | Correspondence

Dichotomy between the humoral and cellular responses elicited by mRNA and adenoviral vector vaccines against SARS-CoV-2
Rahul Ukey, Natalie Bruiners, Hridesh Mishra, Pankaj K. Mishra, Deborah McCloskey, Alberta Onyuka, Fei Chen, Abraham Pinter, Daniela Weiskopf, Alessandro Sette, Jason Roy, Sunanda Gaur, Maria Laura Gennaro

Open Access 01.12.2022 | Research article

Epidemiology and control of SARS-CoV-2 epidemics in partially vaccinated populations: a modeling study applied to France
Paolo Bosetti, Cécile Tran Kiem, Alessio Andronico, Vittoria Colizza, Yazdan Yazdanpanah, Arnaud Fontanet, Daniel Benamouzig, Simon Cauchemez

Open Access 01.12.2022 | Research article

Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomisation using polygenic risk scores
Tom A. Bond, Rebecca C. Richmond, Ville Karhunen, Gabriel Cuellar-Partida, Maria Carolina Borges, Verena Zuber, Alexessander Couto Alves, Dan Mason, Tiffany C. Yang, Marc J. Gunter, Abbas Dehghan, Ioanna Tzoulaki, Sylvain Sebert, David M. Evans, Alex M. Lewin, Paul F. O’Reilly, Deborah A. Lawlor, Marjo-Riitta Järvelin

Open Access 01.12.2022 | Research article

Human placental mesenchymal stromal cells are ciliated and their ciliation is compromised in preeclampsia
Sophia Indira Romberg, Nina-Naomi Kreis, Alexandra Friemel, Susanne Roth, Alice Steglich Souto, Samira Catharina Hoock, Kyra Fischer, Thorsten Nowak, Christine Solbach, Frank Louwen, Andreas Ritter, Juping Yuan

Open Access 01.12.2022 | COVID-19 | Research article

Prediction of long-term kinetics of vaccine-elicited neutralizing antibody and time-varying vaccine-specific efficacy against the SARS-CoV-2 Delta variant by clinical endpoint
Xinhua Chen, Wei Wang, Xinghui Chen, Qianhui Wu, Ruijia Sun, Shijia Ge, Nan Zheng, Wanying Lu, Juan Yang, Lance Rodewald, Hongjie Yu

Open Access 01.12.2022 | COVID-19 | Research article

Investigating vaccine-induced immunity and its effect in mitigating SARS-CoV-2 epidemics in China
Hengcong Liu, Juanjuan Zhang, Jun Cai, Xiaowei Deng, Cheng Peng, Xinghui Chen, Juan Yang, Qianhui Wu, Xinhua Chen, Zhiyuan Chen, Wen Zheng, Cécile Viboud, Wenhong Zhang, Marco Ajelli, Hongjie Yu

Open Access 01.12.2022 | Research article

Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation
Karen Grewal, Yun S. Lee, Ann Smith, Jan J. Brosens, Tom Bourne, Maya Al-Memar, Samit Kundu, David A. MacIntyre, Phillip R. Bennett

Open Access 01.12.2022 | Research article

The role of diet in renal cell carcinoma incidence: an umbrella review of meta-analyses of observational studies
Zhanchen Liao, Zhitao Fang, Siqi Gou, Yong Luo, Yiqi Liu, Zhun He, Xin Li, Yansong Peng, Zheng Fu, Dongjin Li, Haiyun Chen, Zhigang Luo

Open Access 01.12.2022 | Research article

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization
Mark Gormley, Tom Dudding, Linda Kachuri, Kimberley Burrows, Amanda H. W. Chong, Richard M. Martin, Steven J. Thomas, Jessica Tyrrell, Andrew R. Ness, Paul Brennan, Marcus R. Munafò, Miranda Pring, Stefania Boccia, Andrew F. Olshan, Brenda Diergaarde, Rayjean J. Hung, Geoffrey Liu, Eloiza H. Tajara, Patricia Severino, Tatiana N. Toporcov, Martin Lacko, Tim Waterboer, Nicole Brenner, George Davey Smith, Emma E. Vincent, Rebecca C. Richmond

Open Access 01.12.2022 | Research article

Systematic review of Mendelian randomization studies on risk of cancer
Georgios Markozannes, Afroditi Kanellopoulou, Olympia Dimopoulou, Dimitrios Kosmidis, Xiaomeng Zhang, Lijuan Wang, Evropi Theodoratou, Dipender Gill, Stephen Burgess, Konstantinos K. Tsilidis

Open Access 01.12.2022 | Research article

Efficacy and safety of pyrotinib in advanced lung adenocarcinoma with HER2 mutations: a multicenter, single-arm, phase II trial
Zhengbo Song, Yuping Li, Shiqing Chen, Shenpeng Ying, Shuguang Xu, Jianjin Huang, Dan Wu, Dongqing Lv, Ting Bei, Shuxun Liu, Xiaoping Huang, Congying Xie, Xiaoyu Wu, Jianfei Fu, Feng Hua, Wenxian Wang, Chunwei Xu, Chan Gao, Shangli Cai, Shun Lu, Yiping Zhang

Open Access 01.12.2022 | Research article

The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records
Rebecca M. Joseph, Ruth H. Jack, Richard Morriss, Roger David Knaggs, Debbie Butler, Chris Hollis, Julia Hippisley-Cox, Carol Coupland

Open Access 01.12.2022 | Research article

Nonlinear causal effects of estimated glomerular filtration rate on myocardial infarction risks: Mendelian randomization study
Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Hyeok Huh, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim

Open Access 01.12.2022 | Research article

Personalised treatment for cognitive impairment in dementia: development and validation of an artificial intelligence model
Qiang Liu, Nemanja Vaci, Ivan Koychev, Andrey Kormilitzin, Zhenpeng Li, Andrea Cipriani, Alejo Nevado-Holgado

Open Access 01.12.2022 | Research article

Trend and projection of skilled birth attendants and institutional delivery coverage for adolescents in 54 low- and middle-income countries, 2000–2030
Md. Mizanur Rahman, Hiroko Taniguchi, Raïssa Shiyghan Nsashiyi, Rashedul Islam, Syed Riaz Mahmud, Shafiur Rahman, Jenny Jung, Shahjahan Khan

Open Access 01.12.2022 | Research article

Is metabolic syndrome a risk factor in hepatectomy? A meta-analysis with subgroup analysis for histologically confirmed hepatic manifestations
Anastasia Murtha-Lemekhova, Juri Fuchs, Svenja Feiler, Erik Schulz, Miriam Teroerde, Eva Kalkum, Rosa Klotz, Adrian Billeter, Pascal Probst, Katrin Hoffmann

Open Access 01.12.2022 | Research article

Circulating tumor cell gene expression and plasma AR gene copy number as biomarkers for castration-resistant prostate cancer patients treated with cabazitaxel
Giorgia Gurioli, Vincenza Conteduca, Nicole Brighi, Emanuela Scarpi, Umberto Basso, Giuseppe Fornarini, Alessandra Mosca, Maurizio Nicodemo, Giuseppe Luigi Banna, Cristian Lolli, Giuseppe Schepisi, Giorgia Ravaglia, Isabella Bondi, Paola Ulivi, Ugo De Giorgi

Open Access 01.12.2022 | Research article

Effect of an osteoporotic fracture prevention program on fracture incidence in routine care: a cluster-randomized trial
Kilian Rapp, Sarah E. Lamb, Patrick Roigk, Clemens Becker, Claudia Konnopka, Hans-Helmut König, Raphael S. Peter, Dietrich Rothenbacher, Gisela Büchele

Open Access 01.12.2022 | COVID-19 | Opinion

Studying the post-COVID-19 condition: research challenges, strategies, and importance of Core Outcome Set development
Daniel Munblit, Timothy R. Nicholson, Dale M. Needham, Nina Seylanova, Callum Parr, Jessica Chen, Alisa Kokorina, Louise Sigfrid, Danilo Buonsenso, Shinjini Bhatnagar, Ramachandran Thiruvengadam, Ann M. Parker, Jacobus Preller, Sergey Avdeev, Frederikus A. Klok, Allison Tong, Janet V. Diaz, Wouter De Groote, Nicoline Schiess, Athena Akrami, Frances Simpson, Piero Olliaro, Christian Apfelbacher, Regis Goulart Rosa, Jennifer R. Chevinsky, Sharon Saydah, Jochen Schmitt, Alla Guekht, Sarah L. Gorst, Jon Genuneit, Luis Felipe Reyes, Alan Asmanov, Margaret E. O’Hara, Janet T. Scott, Melina Michelen, Charitini Stavropoulou, John O. Warner, Margaret Herridge, Paula R. Williamson

Open Access 01.12.2022 | COVID-19 | Research article

Estimating the effect of non-pharmaceutical interventions to mitigate COVID-19 spread in Saudi Arabia
Donal Bisanzio, Richard Reithinger, Ada Alqunaibet, Sami Almudarra, Reem F. Alsukait, Di Dong, Yi Zhang, Sameh El-Saharty, Christopher H. Herbst

Open Access 01.12.2022 | Research article

Protective action of natural and induced immunization against the occurrence of delta or alpha variants of SARS-CoV-2 infection: a test-negative case-control study
Giovanni Corrao, Matteo Franchi, Federico Rea, Danilo Cereda, Antonio Barone, Catia Rosanna Borriello, Petra Giulia Della Valle, Michele Ercolanoni, Ida Fortino, Jose Jara, Olivia Leoni, Francesco Mazziotta, Elisabetta Pierini, Giuseppe Preziosi, Marcello Tirani, Massimo Galli, Guido Bertolaso, Giovanni Pavesi, Francesco Bortolan

Open Access 01.12.2022 | Research article

Multimorbidity and co-occurring musculoskeletal pain do not modify the effect of the selfBACK app on low back pain-related disability
Cecilie K. Øverås, Tom I. L. Nilsen, Barbara I. Nicholl, Guy Rughani, Karen Wood, Karen Søgaard, Frances S. Mair, Jan Hartvigsen

Open Access 01.12.2022 | Research article

Systematic review and meta-analysis of the diagnostic accuracy of prostate-specific antigen (PSA) for the detection of prostate cancer in symptomatic patients
Samuel W. D. Merriel, Lucy Pocock, Emma Gilbert, Sam Creavin, Fiona M. Walter, Anne Spencer, Willie Hamilton

Open Access 01.12.2022 | Research article

Upregulation of NOD1 and NOD2 contribute to cancer progression through the positive regulation of tumorigenicity and metastasis in human squamous cervical cancer
Yuanyuan Zhang, Ning Li, Guangwen Yuan, Hongwen Yao, Die Zhang, Nan Li, Gongyi Zhang, Yangchun Sun, Wenpeng Wang, Jia Zeng, Ningzhi Xu, Mei Liu, Lingying Wu

Open Access 01.12.2022 | Research article

Effects of personalized diets by prediction of glycemic responses on glycemic control and metabolic health in newly diagnosed T2DM: a randomized dietary intervention pilot trial
Michal Rein, Orly Ben-Yacov, Anastasia Godneva, Smadar Shilo, Niv Zmora, Dmitry Kolobkov, Noa Cohen-Dolev, Bat-Chen Wolf, Noa Kosower, Maya Lotan-Pompan, Adina Weinberger, Zamir Halpern, Shira Zelber-Sagi, Eran Elinav, Eran Segal

Open Access 01.12.2022 | Research article

Observed and predicted premature mortality in Australia due to non-communicable diseases: a population-based study examining progress towards the WHO 25X25 goal
Alison Wijnen, Karen Bishop, Grace Joshy, Yuehan Zhang, Emily Banks, Ellie Paige

Open Access 01.12.2022 | Research article

Regional-based within-year seasonal variations in influenza-related health outcomes across mainland China: a systematic review and spatio-temporal analysis
Charlie Diamond, Hui Gong, Fiona Yueqian Sun, Yang Liu, Billy J. Quilty, Mark Jit, Juan Yang, Hongjie Yu, W. John Edmunds, Marc Baguelin

Open Access 01.12.2022 | Research article

c-MET/VEGFR-2 co-localisation impacts on survival following bevacizumab therapy in epithelial ovarian cancer: an exploratory biomarker study of the phase 3 ICON7 trial
Robert D. Morgan, Cristina Ferreras, Isabel Peset, Egle Avizienyte, Andrew G. Renehan, Richard J. Edmondson, Alexander D. Murphy, Shibani Nicum, Thomas Van Brussel, Andrew R. Clamp, Diether Lambrechts, Cong Zhou, Gordon C. Jayson

Open Access 01.12.2022 | Research article

Association between adverse childhood experiences and premenstrual disorders: a cross-sectional analysis of 11,973 women
Qian Yang, Edda Björk Þórðardóttir, Arna Hauksdóttir, Thor Aspelund, Jóhanna Jakobsdóttir, Thorhildur Halldorsdottir, Gunnar Tomasson, Harpa Rúnarsdóttir, Hilda Björk Danielsdottir, Elizabeth R. Bertone-Johnson, Arvid Sjölander, Fang Fang, Donghao Lu, Unnur Anna Valdimarsdóttir

Open Access 01.12.2022 | Research article

Associations between cervical intraepithelial neoplasia during pregnancy, previous excisional treatment, cone-length and preterm delivery: a register-based study from western Sweden
Johanna Wiik, Cecilia Kärrberg, Staffan Nilsson, Björn Strander, Bo Jacobsson, Verena Sengpiel

Open Access 01.12.2022 | Research article

High polygenic predisposition for ADHD and a greater risk of all-cause mortality: a large population-based longitudinal study
Olesya Ajnakina, Diana Shamsutdinova, Theresa Wimberley, Søren Dalsgaard, Andrew Steptoe

Open Access 01.12.2022 | Research article

Lifetime risk of cardiovascular-renal disease in type 2 diabetes: a population-based study in 473,399 individuals
Ruiqi Zhang, Jil Billy Mamza, Tamsin Morris, George Godfrey, Folkert W. Asselbergs, Spiros Denaxas, Harry Hemingway, Amitava Banerjee

Open Access 01.12.2022 | Research article

Common DNA methylation changes in biliary tract cancers identify subtypes with different immune characteristics and clinical outcomes
Zhiquan Qiu, Jun Ji, Yu Xu, Yan Zhu, Chunfang Gao, Guoqiang Wang, Chengcheng Li, Yuzi Zhang, Jing Zhao, Chenyang Wang, Xiaofang Wen, Zhou Zhang, Bingsi Li, Zhihong Zhang, Shangli Cai, Bin Li, Xiaoqing Jiang

Open Access 01.12.2022 | Research article

Obesity, metabolic risk and adherence to healthy lifestyle behaviours: prospective cohort study in the UK Biobank
Laura Heath, Susan A. Jebb, Paul Aveyard, Carmen Piernas

Open Access 01.12.2022 | Research article

Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis
Qianwen Liu, Zhaozhong Zhu, Peter Kraft, Qiaolin Deng, Elisabet Stener-Victorin, Xia Jiang

Open Access 01.12.2022 | Research article

Enhanced intestinal protein fermentation in schizophrenia
Ying Liang, Xing Shi, Yang Shen, Zhuoran Huang, Jian Wang, Changjun Shao, Yanan Chu, Jing Chen, Jun Yu, Yu Kang

Open Access 01.12.2022 | Research article

Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants
Rui Chen, Jiewei Liu, Shiwu Li, Xiaoyan Li, Yongxia Huo, Yong-Gang Yao, Xiao Xiao, Ming Li, Xiong-Jian Luo

Open Access 01.12.2022 | Research article

The impact of kidney function in patients on antithrombotic therapy: a post hoc subgroup analysis focusing on recurrent bleeding events from the AFIRE trial
Kunihiko Matsui, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Kazuo Kimura, Atsushi Hirayama, Hisao Ogawa

Open Access 01.12.2022 | Research article

Risk/benefit tradeoff of habitual physical activity and air pollution on chronic pulmonary obstructive disease: findings from a large prospective cohort study
Lan Chen, Miao Cai, Haitao Li, Xiaojie Wang, Fei Tian, Yinglin Wu, Zilong Zhang, Hualiang Lin

Open Access 01.12.2022 | Research article

Global prevalence and burden of meal-related abdominal pain
Esther Colomier, Chloé Melchior, Joost P. Algera, Jóhann P. Hreinsson, Stine Störsrud, Hans Törnblom, Lukas Van Oudenhove, Olafur S. Palsson, Shrikant I. Bangdiwala, Ami D. Sperber, Jan Tack, Magnus Simrén

Open Access 01.12.2022 | Forum

The impact of race and ethnicity in breast cancer—disparities and implications for precision oncology
Kelly A. Hirko, Gabrielle Rocque, Erica Reasor, Ammanuel Taye, Alex Daly, Ramsey I. Cutress, Ellen R. Copson, Dae-Won Lee, Kyung-Hun Lee, Seock-Ah Im, Yeon Hee Park

Open Access 01.12.2022 | Research article

Risk of cancer in regular and low meat-eaters, fish-eaters, and vegetarians: a prospective analysis of UK Biobank participants
Cody Z. Watling, Julie A. Schmidt, Yashvee Dunneram, Tammy Y. N. Tong, Rebecca K. Kelly, Anika Knuppel, Ruth C. Travis, Timothy J. Key, Aurora Perez-Cornago

Open Access 01.12.2022 | Research article

Deep learning radiomics based on contrast-enhanced ultrasound images for assisted diagnosis of pancreatic ductal adenocarcinoma and chronic pancreatitis
Tong Tong, Jionghui Gu, Dong Xu, Ling Song, Qiyu Zhao, Fang Cheng, Zhiqiang Yuan, Shuyuan Tian, Xin Yang, Jie Tian, Kun Wang, Tian’an Jiang

Open Access 01.12.2022 | Research article

Promoting deceased organ and tissue donation registration in family physician waiting rooms (RegisterNow-1): a pragmatic stepped-wedge, cluster randomized controlled registry trial
Alvin Ho-ting Li, Amit X. Garg, Jeremy M. Grimshaw, Versha Prakash, Alexie J. Dunnett, Stephanie N. Dixon, Monica Taljaard, Joanna Mitchell, Kyla L. Naylor, Cathy Faulds, Rachel Bevan, Leah Getchell, Greg Knoll, S. Joseph Kim, Jessica Sontrop, Allison Tong, Lise M. Bjerre, Karyn Hyjek, Donna Currie, Susan Edwards, Mike Sullivan, Linda Harvey-Rioux, Justin Presseau

Open Access 01.12.2022 | Research article

GWAS in people of Middle Eastern descent reveals a locus protective of kidney function—a cross-sectional study
Siham A. Mohamed, Juan Fernadez-Tajes, Paul W. Franks, Louise Bennet

Open Access 01.12.2022 | Research article

The impact of local vaccine coverage and recent incidence on measles transmission in France between 2009 and 2018
Alexis Robert, Adam J. Kucharski, Sebastian Funk

Open Access 01.12.2022 | Research article

Predictive validity of the Stopping Elderly Accidents, Deaths & Injuries (STEADI) program fall risk screening algorithms among community-dwelling Thai elderly
Sriprapa Loonlawong, Weerawat Limroongreungrat, Thanapoom Rattananupong, Kamonrat Kittipimpanon, Wanvisa Saisanan Na Ayudhaya, Wiroj Jiamjarasrangsi

Open Access 01.12.2022 | Research article

Association of meat, vegetarian, pescatarian and fish-poultry diets with risk of 19 cancer sites and all cancer: findings from the UK Biobank prospective cohort study and meta-analysis
Solange Parra-Soto, Danay Ahumada, Fanny Petermann-Rocha, Jirapitcha Boonpoor, Jose Lara Gallegos, Jana Anderson, Linda Sharp, Fiona C. Malcomson, Katherine M. Livingstone, John C. Mathers, Jill P. Pell, Frederick K. Ho, Carlos Celis-Morales

Open Access 01.12.2022 | COVID-19 | Research article

Mitigating the SARS-CoV-2 Delta disease burden in Australia by non-pharmaceutical interventions and vaccinating children: a modelling analysis
George J. Milne, Julian Carrivick, David Whyatt

Open Access 01.12.2022 | Commentary

Vegetarian diets and cancer risk
Mathias Weller

Open Access 01.12.2022 | Research article

Asthma and the risk of gastrointestinal disorders: a Mendelian randomization study
Dennis Freuer, Jakob Linseisen, Christa Meisinger

Open Access 01.12.2022 | COVID-19 | Research article

A single-oral bolus of 100,000 IU of cholecalciferol at hospital admission did not improve outcomes in the COVID-19 disease: the COVID-VIT-D—a randomised multicentre international clinical trial
Jorge B. Cannata-Andía, Augusto Díaz-Sottolano, Pehuén Fernández, Carmen Palomo-Antequera, Pablo Herrero-Puente, Ricardo Mouzo, Natalia Carrillo-López, Sara Panizo, Guillermo H. Ibañez, Carlos A. Cusumano, Carolina Ballarino, Vicente Sánchez-Polo, Jacqueline Pefaur-Penna, Irene Maderuelo-Riesco, Jesús Calviño-Varela, Mónica D. Gómez, Carlos Gómez-Alonso, John Cunningham, Manuel Naves-Díaz, Walter Douthat, José L. Fernández-Martín, the COVID-VIT-D trial collaborators

Open Access 01.12.2022 | Research article

Activity and safety of SHR3680, a novel antiandrogen, in patients with metastatic castration-resistant prostate cancer: a phase I/II trial
Xiaojian Qin, Dongmei Ji, Weijie Gu, Weiqing Han, Hong Luo, Chuanjun Du, Qing Zou, Zhongquan Sun, Chaohong He, Shaoxing Zhu, Tie Chong, Xin Yao, Ben Wan, Xinfeng Yang, Aobing Bai, Chunlei Jin, Jianjun Zou, Dingwei Ye

Open Access 01.12.2022 | Research article

Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data
The WorldWide Antimalarial Resistance Network Falciparum Haematology Study Group

Open Access 01.12.2022 | COVID-19 | Research article

Comparative assessment of methods for short-term forecasts of COVID-19 hospital admissions in England at the local level
Sophie Meakin, Sam Abbott, Nikos Bosse, James Munday, Hugo Gruson, Joel Hellewell, Katharine Sherratt, Sebastian Funk, CMMID COVID-19 Working Group

Open Access 01.12.2022 | Research article

Determinants of pre-vaccination antibody responses to SARS-CoV-2: a population-based longitudinal study (COVIDENCE UK)
Mohammad Talaei, Sian Faustini, Hayley Holt, David A. Jolliffe, Giulia Vivaldi, Matthew Greenig, Natalia Perdek, Sheena Maltby, Carola M. Bigogno, Jane Symons, Gwyneth A. Davies, Ronan A. Lyons, Christopher J. Griffiths, Frank Kee, Aziz Sheikh, Alex G. Richter, Seif O. Shaheen, Adrian R. Martineau

Open Access 01.12.2022 | Guideline

WHO-led consensus statement on vaccine delivery costing: process, methods, and findings
Ann Levin, Laura Boonstoppel, Logan Brenzel, Ulla Griffiths, Raymond Hutubessy, Mark Jit, Vittal Mogasale, Sarah Pallas, Stephen Resch, Christian Suharlim, Karene Hoi Ting Yeung

Open Access 01.12.2022 | Research article

Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand
Zoe Shih-Jung Liu, Jetsumon Sattabongkot, Michael White, Sadudee Chotirat, Chalermpon Kumpitak, Eizo Takashima, Matthias Harbers, Wai-Hong Tham, Julie Healer, Chetan E. Chitnis, Takafumi Tsuboi, Ivo Mueller, Rhea J. Longley

Open Access 01.12.2022 | Editorial

Targeted therapies for cancer
Zhijun Zhou, Min Li

Open Access 01.12.2022 | Research article

Heart rate variability is associated with left ventricular systolic, diastolic function and incident heart failure in the general population
Banafsheh Arshi, Sven Geurts, Martijn J. Tilly, Marten van den Berg, Jan A. Kors, Dimitris Rizopoulos, M. Arfan Ikram, Maryam Kavousi

Open Access 01.12.2022 | COVID-19 | Research article

Long COVID 12 months after discharge: persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes—a multicentre cohort study
Mario Rivera-Izquierdo, Antonio Jesús Láinez-Ramos-Bossini, Inmaculada Guerrero-Fernández de Alba, Rocío Ortiz-González-Serna, Álvaro Serrano-Ortiz, Nicolás Francisco Fernández-Martínez, Rafael Ruiz-Montero, Jorge A. Cervilla

Open Access 01.12.2022 | Research article

Ezetimibe combination therapy with statin for non-alcoholic fatty liver disease: an open-label randomized controlled trial (ESSENTIAL study)
Yongin Cho, Hyungjin Rhee, Young-eun Kim, Minyoung Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Jin-Young Choi, Yong-ho Lee

Open Access 01.12.2022 | Research article

The influence of childhood asthma on adult height: evidence from the UK Biobank
Wenwen Chen, Huazhen Yang, Can Hou, Yajing Sun, Yanan Shang, Yu Zeng, Yao Hu, Yuanyuan Qu, Jianwei Zhu, Fang Fang, Donghao Lu, Huan Song

Open Access 01.12.2022 | Research article

Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes
Jérémie Gautheron, Lara Lima, Baris Akinci, Jamila Zammouri, Martine Auclair, Sema Kalkan Ucar, Samim Ozen, Canan Altay, Bridget E. Bax, Ivan Nemazanyy, Véronique Lenoir, Carina Prip-Buus, Cécile Acquaviva-Bourdain, Olivier Lascols, Bruno Fève, Corinne Vigouroux, Esther Noel, Isabelle Jéru

Open Access 01.12.2022 | Research article

The University of Padua salivary-based SARS-CoV-2 surveillance program minimized viral transmission during the second and third pandemic wave
Daniela Basso, Ada Aita, Filippo Navaglia, Paola Mason, Stefania Moz, Alessio Pinato, Barbara Melloni, Luca Iannelli, Andrea Padoan, Chiara Cosma, Angelo Moretto, Alberto Scuttari, Daniela Mapelli, Rosario Rizzuto, Mario Plebani

Open Access 01.12.2022 | COVID-19 | Research article

Detection of SARS-CoV-2 infection in the general population by three prevailing rapid antigen tests: cross-sectional diagnostic accuracy study
Roderick P. Venekamp, Irene K. Veldhuijzen, Karel G. M. Moons, Wouter van den Bijllaardt, Suzan D. Pas, Esther B. Lodder, Richard Molenkamp, Zsofi Igloi, Constantijn Wijers, Claudy Oliveira dos Santos, Sylvia B. Debast, Marjan J. Bruins, Khaled Polad, Carla R. S. Nagel-Imming, Wanda G. H. Han, Janneke H. H. M. van de Wijgert, Susan van den Hof, Ewoud Schuit

Open Access 01.12.2022 | Research article

Developing sero-diagnostic tests to facilitate Plasmodium vivax Serological Test-and-Treat approaches: modeling the balance between public health impact and overtreatment
Thomas Obadia, Narimane Nekkab, Leanne J. Robinson, Chris Drakeley, Ivo Mueller, Michael T. White

Open Access 01.12.2022 | Correction

Correction to: The epidemiologic impact and cost-effectiveness of new tuberculosis vaccines on multidrug-resistant tuberculosis in India and China
Chathika K. Weerasuriya, Rebecca C. Harris, C. Finn McQuaid, Fiammetta Bozzani, Yunzhou Ruan, Renzhong Li, Tao Li, Kirankumar Rade, Raghuram Rao, Ann M. Ginsberg, Gabriela B. Gomez, Richard G. White

Open Access 01.12.2022 | Correspondence

Risk factors associated with short-term adverse events after SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases
Luuk Wieske, Laura Y. L. Kummer, Koos P. J. van Dam, Eileen W. Stalman, Anneke J. van der Kooi, Joost Raaphorst, Mark Löwenberg, R. Bart Takkenberg, Adriaan G. Volkers, Geert R. A. M. D’Haens, Sander W. Tas, Phyllis I. Spuls, Marcel W. Bekkenk, Annelie H. Musters, Nicoline F. Post, Angela L. Bosma, Marc L. Hilhorst, Yosta Vegting, Frederike J. Bemelman, Joep Killestein, Zoé L. E. van Kempen, Alexandre E. Voskuyl, Bo Broens, Agner Parra Sanchez, Gertjan Wolbink, Laura Boekel, Abraham Rutgers, Karina de Leeuw, Barbara Horváth, Jan J. G. M. Verschuuren, Annabel M. Ruiter, Lotte van Ouwerkerk, Diane van der Woude, Cornelia F. Allaart, Y. K. Onno Teng, Pieter van Paassen, Matthias H. Busch, B. Papay Jallah, Esther Brusse, Pieter A. van Doorn, Adája E. Baars, Dirkjan Hijnen, Corine R. G. Schreurs, W. Ludo van der Pol, H. Stephan Goedee, Maurice Steenhuis, Theo Rispens, Anja ten Brinke, Niels J. M. Verstegen, Koos A. H. Zwinderman, S. Marieke van Ham, Taco W. Kuijpers, Filip Eftimov, on behalf of the T2B! immunity against SARS-CoV-2 study group

Open Access 01.12.2022 | Research article

An international consensus on the essential and desirable criteria for an ‘organized’ cancer screening programme
Li Zhang, André L. Carvalho, Isabel Mosquera, Tianmeng Wen, Eric Lucas, Catherine Sauvaget, Richard Muwonge, Marc Arbyn, Elisabete Weiderpass, Partha Basu

Open Access 01.12.2022 | COVID-19 | Research article

Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant
Maren Schubert, Federico Bertoglio, Stephan Steinke, Philip Alexander Heine, Mario Alberto Ynga-Durand, Henrike Maass, Josè Camilla Sammartino, Irene Cassaniti, Fanglei Zuo, Likun Du, Janin Korn, Marko Milošević, Esther Veronika Wenzel, Fran Krstanović, Saskia Polten, Marina Pribanić-Matešić, Ilija Brizić, Fausto Baldanti, Lennart Hammarström, Stefan Dübel, Alan Šustić, Harold Marcotte, Monika Strengert, Alen Protić, Antonio Piralla, Qiang Pan-Hammarström, Luka Čičin-Šain, Michael Hust

Open Access 01.12.2022 | Research article

The relationships between women’s reproductive factors: a Mendelian randomisation analysis
Claire Prince, Gemma C. Sharp, Laura D. Howe, Abigail Fraser, Rebecca C. Richmond

Open Access 01.12.2022 | Research article

The association between assisted reproductive technology and cardiac remodeling in fetuses and early infants: a prospective cohort study
Wenjing Bi, Yangjie Xiao, Xin Wang, Li Cui, Guang Song, Zeyu Yang, Ying Zhang, Weidong Ren

Open Access 01.12.2022 | Research article

HER2 expression, copy number variation and survival outcomes in HER2-low non-metastatic breast cancer: an international multicentre cohort study and TCGA-METABRIC analysis
Ryan Shea Ying Cong Tan, Whee Sze Ong, Kyung-Hun Lee, Abner Herbert Lim, Seri Park, Yeon Hee Park, Ching-Hung Lin, Yen-Shen Lu, Makiko Ono, Takayuki Ueno, Yoichi Naito, Tatsuya Onishi, Geok-Hoon Lim, Su-Ming Tan, Han-Byoel Lee, Han Suk Ryu, Wonshik Han, Veronique Kiak Mien Tan, Fuh-Yong Wong, Seock-Ah Im, Puay Hoon Tan, Jason Yongsheng Chan, Yoon-Sim Yap

Open Access 01.12.2022 | Research article

The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design
Madeleine Michaëlsson, Shuai Yuan, Håkan Melhus, John A. Baron, Liisa Byberg, Susanna C. Larsson, Karl Michaëlsson

Open Access 01.12.2022 | Research article

Neoadjuvant apatinib combined with oxaliplatin and capecitabine in patients with locally advanced adenocarcinoma of stomach or gastroesophageal junction: a single-arm, open-label, phase 2 trial
Zhaoqing Tang, Yan Wang, Yiyi Yu, Yuehong Cui, Liang Liang, Chen Xu, Zhenbin Shen, Kuntang Shen, Xuefei Wang, Tianshu Liu, Yihong Sun

Open Access 01.12.2022 | Research article

Selinexor plus low-dose dexamethasone in Chinese patients with relapsed/refractory multiple myeloma previously treated with an immunomodulatory agent and a proteasome inhibitor (MARCH): a phase II, single-arm study
Lugui Qiu, Zhongjun Xia, Chengcheng Fu, Wenming Chen, Chunkang Chang, Baijun Fang, Gang An, Yongqiang Wei, Zhen Cai, Sujun Gao, Jianyu Weng, Lijuan Chen, Hongmei Jing, Fei Li, Zhuogang Liu, Xiequn Chen, Jing Liu, Aihua Wang, Yang Yu, Wenxi Xiang, Kevin Lynch, Zhinuan Yu, Weijun Fu

Open Access 01.12.2022 | Research article

The compensatory reserve index predicts recurrent shock in patients with severe dengue
Huynh Trung Trieu, Lam Phung Khanh, Damien Keng Yen Ming, Chanh Ho Quang, Tu Qui Phan, Vinh Chau Nguyen Van, Ertan Deniz, Jane Mulligan, Bridget Ann Wills, Steven Moulton, Sophie Yacoub

Open Access 01.12.2022 | Research article

Physical activity enhances the improvement of body mass index and metabolism by inulin: a multicenter randomized placebo-controlled trial performed in obese individuals
Julie Rodriguez, Audrey M. Neyrinck, Maxime Van Kerckhoven, Marco A. Gianfrancesco, Edith Renguet, Luc Bertrand, Patrice D. Cani, Nicolas Lanthier, Miriam Cnop, Nicolas Paquot, Jean-Paul Thissen, Laure B. Bindels, Nathalie M. Delzenne

Open Access 01.12.2022 | Research article

Differences in risk factors for incident and recurrent preterm birth: a population-based linkage of 3.5 million births from the CIDACS birth cohort
Aline S. Rocha, Rita de Cássia Ribeiro-Silva, Rosemeire L. Fiaccone, Enny S. Paixao, Ila R. Falcão, Flavia Jôse O. Alves, Natanael J. Silva, Naiá Ortelan, Laura C. Rodrigues, Maria Yury Ichihara, Marcia F. de Almeida, Mauricio L. Barreto

Open Access 01.12.2022 | Research article

Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer
Blossom Mak, Hui-Ming Lin, Edmond M. Kwan, Heidi Fettke, Ben Tran, Ian D. Davis, Kate Mahon, Martin R. Stockler, Karen Briscoe, Gavin Marx, Alison Zhang, Megan Crumbaker, Winston Tan, Kevin Huynh, Thomas G. Meikle, Natalie A. Mellett, Andrew J. Hoy, Pan Du, Jianjun Yu, Shidong Jia, Anthony M. Joshua, David J. Waugh, Lisa M. Butler, Manish Kohli, Peter J. Meikle, Arun A. Azad, Lisa G. Horvath

Open Access 01.12.2022 | Research article

Differential health impact of intervention programs for time-varying disease risk: a measles vaccination modeling study
Allison Portnoy, Yuli Lily Hsieh, Kaja Abbas, Petra Klepac, Heather Santos, Logan Brenzel, Mark Jit, Matthew Ferrari

Open Access 01.12.2022 | Question and Answer

Maternal factors during pregnancy influencing maternal, fetal and childhood outcomes: Meet the Guest Editors
Louis Muglia, Stephen Tong, Susan Ozanne, Katrien Benhalima

Open Access 01.12.2022 | Opinion

Immune responses in the irritable bowel syndromes: time to consider the small intestine
Grace L. Burns, Nicholas J. Talley, Simon Keely

Open Access 01.12.2022 | Research article

Combining faecal immunochemical testing with blood test results for colorectal cancer risk stratification: a consecutive cohort of 16,604 patients presenting to primary care
Diana R. Withrow, Brian Shine, Jason Oke, Andres Tamm, Tim James, Eva Morris, Jim Davies, Steve Harris, James E. East, Brian D. Nicholson

Open Access 01.12.2022 | Review

Assessment of glycemia in chronic kidney disease
Mohamed Hassanein, Tariq Shafi

Open Access 01.12.2022 | Research article

Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
Manon Cairat, Sabina Rinaldi, Anne-Sophie Navionis, Isabelle Romieu, Carine Biessy, Vivian Viallon, Anja Olsen, Anne Tjønneland, Agnès Fournier, Gianluca Severi, Marina Kvaskoff, Renée T. Fortner, Rudolf Kaaks, Krasimira Aleksandrova, Matthias B. Schulze, Giovanna Masala, Rosario Tumino, Sabina Sieri, Chiara Grasso, Amalia Mattiello, Inger T. Gram, Karina Standahl Olsen, Antonio Agudo, Pilar Amiano Etxezarreta, Maria-Jose Sánchez, Carmen Santiuste, Aurelio Barricarte, Evelyn Monninkhof, Anouk E. Hiensch, David Muller, Melissa A. Merritt, Ruth C. Travis, Elisabete Weiderpass, Marc J. Gunter, Laure Dossus

Open Access 01.12.2022 | Research article

Impact of a delayed second dose of mRNA vaccine (BNT162b2) and inactivated SARS-CoV-2 vaccine (CoronaVac) on risks of all-cause mortality, emergency department visit, and unscheduled hospitalization
Carlos King Ho Wong, Xi Xiong, Kristy Tsz Kwan Lau, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Esther Wai Yin Chan, Eric Yuk Fai Wan, Ivan Chi Ho Au, Benjamin John Cowling, Cheuk Kwong Lee, Ian Chi Kei Wong

Open Access 01.12.2022 | Research article

Organ-specific metastatic landscape dissects PD-(L)1 blockade efficacy in advanced non-small cell lung cancer: applicability from clinical trials to real-world practice
Si-Cong Ma, Xue Bai, Xue-Jun Guo, Li Liu, Lu-Shan Xiao, Yan Lin, Jia-Le Tan, Xiao-Ting Cai, Yu-Xiang Wen, Hu Ma, Q. John Fu, Meng-Xin Leng, Yan-Pei Zhang, Li-Li Long, Ze-Qin Guo, De-Hua Wu, Jian-Guo Zhou, Zhong-Yi Dong

Open Access 01.12.2022 | Correction

Correction to: Lifetime risk of cardiovascular-renal disease in type 2 diabetes: a population-based study in 473,399 individuals
Ruiqi Zhang, Jil Billy Mamza, Tamsin Morris, George Godfrey, Folkert W. Asselbergs, Spiros Denaxas, Harry Hemingway, Amitava Banerjee

Open Access 01.12.2022 | Research article

A healthy dietary metabolic signature is associated with a lower risk for type 2 diabetes and coronary artery disease
Einar Smith, Ulrika Ericson, Sophie Hellstrand, Marju Orho-Melander, Peter M. Nilsson, Céline Fernandez, Olle Melander, Filip Ottosson

Open Access 01.12.2022 | Research article

The association of neurodevelopmental abnormalities, congenital heart and renal defects in a tuberous sclerosis complex patient cohort
Jessica Robinson, Orhan Uzun, Ne Ron Loh, Isabelle Rose Harris, Thomas E. Woolley, Adrian J. Harwood, Jennifer Frances Gardner, Yasir Ahmed Syed

Open Access 01.12.2022 | Research article

Effects of providing free hearing aids on multiple health outcomes among middle-aged and older adults with hearing loss in rural China: a randomized controlled trial
Xin Ye, Dawei Zhu, Siyuan Chen, Xuefeng Shi, Rui Gong, Juncheng Wang, Huibin Zuo, Ping He

Open Access 01.12.2022 | Research article

Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis
Emma Hazelwood, Eleanor Sanderson, Vanessa Y. Tan, Katherine S. Ruth, Timothy M. Frayling, Niki Dimou, Marc J. Gunter, Laure Dossus, Claire Newton, Neil Ryan, Dimitri J. Pournaras, Tracy A. O’Mara, George Davey Smith, Richard M. Martin, James Yarmolinsky

Open Access 01.12.2022 | Correction

Correction to: P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss
Caiyun Ge, Dan Xu, Pengxia Yu, Man Fang, Juanjuan Guo, Dan Xu, Yuan Qiao, Sijia Chen, Yuanzhen Zhang, Hui Wang

Open Access 01.12.2022 | Research article

Diabetic kidney disease and risk of incident stroke among adults with type 2 diabetes
Arnaud D. Kaze, Bernard G. Jaar, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui

Open Access 01.12.2022 | COVID-19 | Research article

AstraZeneca COVID-19 vaccine induces robust broadly cross-reactive antibody responses in Malawian adults previously infected with SARS-CoV-2
Marah G. Chibwana, Thandeka Moyo-Gwete, Gaurav Kwatra, Jonathan Mandolo, Tandile Hermanaus, Thopisang Motlou, Nonkululeko Mzindle, Frances Ayres, Mphatso Chaponda, Godwin Tembo, Percy Mwenechanya, Ndaona Mitole, Chisomo Jassi, Raphael Kamng’ona, Louise Afran, David Mzinza, Henry C. Mwandumba, Stephen B. Gordon, Khuzwayo Jere, Shabir Madhi, Penny L. Moore, Robert S. Heyderman, Kondwani C. Jambo

Open Access 01.12.2022 | COVID-19 | Research article

Recovery of serum testosterone levels is an accurate predictor of survival from COVID-19 in male patients
Emily Toscano-Guerra, Mónica Martínez-Gallo, Iria Arrese-Muñoz, Anna Giné, Noelia Díaz-Troyano, Pablo Gabriel-Medina, Mar Riveiro-Barciela, Moisés Labrador-Horrillo, Fernando Martinez-Valle, Adrián Sánchez Montalvá, Manuel Hernández-González, Ricardo Pujol Borrell, Francisco Rodríguez-Frias, Roser Ferrer, Timothy M. Thomson, Rosanna Paciucci

Open Access 01.12.2022 | COVID-19 | Research article

Global diversity of policy, coverage, and demand of COVID-19 vaccines: a descriptive study
Zhiyuan Chen, Wen Zheng, Qianhui Wu, Xinghui Chen, Cheng Peng, Yuyang Tian, Ruijia Sun, Jiayi Dong, Minghan Wang, Xiaoyu Zhou, Zeyao Zhao, Guangjie Zhong, Xuemei Yan, Nuolan Liu, Feiran Hao, Sihong Zhao, Tingyu Zhuang, Juan Yang, Andrew S. Azman, Hongjie Yu

Open Access 01.12.2022 | Research article

Shared genetic links between frontotemporal dementia and psychiatric disorders
Chunyu Li, Dejiang Pang, Junyu Lin, Tianmi Yang, Huifang Shang

Open Access 01.12.2022 | Research article

Time spent in outdoor light is associated with the risk of dementia: a prospective cohort study of 362094 participants
Ling-Zhi Ma, Ya-Hui Ma, Ya-Nan Ou, Shi-Dong Chen, Liu Yang, Qiang Dong, Wei Cheng, Lan Tan, Jin-Tai Yu

Open Access 01.12.2022 | Research article

Mutations of PI3K-AKT-mTOR pathway as predictors for immune cell infiltration and immunotherapy efficacy in dMMR/MSI-H gastric adenocarcinoma
Zhenghang Wang, Xinyu Wang, Yu Xu, Jian Li, Xiaotian Zhang, Zhi Peng, Yajie Hu, Xinya Zhao, Kun Dong, Bei Zhang, Chan Gao, Xiaochen Zhao, Hui Chen, Jinping Cai, Yuezong Bai, Yu Sun, Lin Shen

Open Access 01.12.2022 | Research article

Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people
Maria G. Kakkoura, Huaidong Du, Yu Guo, Canqing Yu, Ling Yang, Pei Pei, Yiping Chen, Sam Sansome, Wing Ching Chan, Xiaoming Yang, Lei Fan, Jun Lv, Junshi Chen, Liming Li, Timothy J. Key, Zhengming Chen, on behalf of the China Kadoorie Biobank (CKB) Collaborative Group

Open Access 01.12.2022 | Research article

The potential impact of Anopheles stephensi establishment on the transmission of Plasmodium falciparum in Ethiopia and prospective control measures
Arran Hamlet, Dereje Dengela, J. Eric Tongren, Fitsum G. Tadesse, Teun Bousema, Marianne Sinka, Aklilu Seyoum, Seth R. Irish, Jennifer S. Armistead, Thomas Churcher

Open Access 01.12.2022 | Research article

Immune microenvironment, homologous recombination deficiency, and therapeutic response to neoadjuvant chemotherapy in triple-negative breast cancer: Japan Breast Cancer Research Group (JBCRG)22 TR
Takayuki Ueno, Shigehisa Kitano, Norikazu Masuda, Daiki Ikarashi, Makiko Yamashita, Tomohiro Chiba, Takayuki Kadoya, Hiroko Bando, Takashi Yamanaka, Shoichiro Ohtani, Shigenori Nagai, Takahiro Nakayama, Masato Takahashi, Shigehira Saji, Kenjiro Aogi, Ravi Velaga, Kosuke Kawaguchi, Satoshi Morita, Hironori Haga, Shinji Ohno, Masakazu Toi

Open Access 01.12.2022 | Research article

Autism spectrum disorders as a risk factor for adolescent self-harm: a retrospective cohort study of 113,286 young people in the UK
Emily Widnall, Sophie Epstein, Catherine Polling, Sumithra Velupillai, Amelia Jewell, Rina Dutta, Emily Simonoff, Robert Stewart, Ruth Gilbert, Tamsin Ford, Matthew Hotopf, Richard D. Hayes, Johnny Downs

Open Access 01.12.2022 | Research article

Healthy lifestyle counteracts the risk effect of genetic factors on incident gout: a large population-based longitudinal study
Yuan Zhang, Rongrong Yang, Abigail Dove, Xuerui Li, Hongxi Yang, Shu Li, Ju Wang, Wei-Dong Li, Hongyu Zhao, Weili Xu, Yaogang Wang

Open Access 01.12.2022 | Research article

Dietary fibre in hypertension and cardiovascular disease management: systematic review and meta-analyses
Andrew N. Reynolds, Ashley Akerman, Shiristi Kumar, Huyen Tran Diep Pham, Sean Coffey, Jim Mann

Open Access 01.12.2022 | Research article

Prophylactic NAC promoted hematopoietic reconstitution by improving endothelial cells after haploidentical HSCT: a phase 3, open-label randomized trial
Yu Wang, Yuan Kong, Hong-Yan Zhao, Yuan-Yuan Zhang, Ya-Zhe Wang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang

Open Access 01.12.2022 | Research article

Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth
Heli Tiensuu, Antti M. Haapalainen, Pinja Tissarinen, Anu Pasanen, Tomi A. Määttä, Johanna M. Huusko, Steffen Ohlmeier, Ulrich Bergmann, Marja Ojaniemi, Louis J. Muglia, Mikko Hallman, Mika Rämet

Open Access 01.12.2022 | Research article

Distinct clinical and somatic mutational features of breast tumors with high-, low-, or non-expressing human epidermal growth factor receptor 2 status
Guochun Zhang, Chongyang Ren, Cheukfai Li, Yulei Wang, Bo Chen, Lingzhu Wen, Minghan Jia, Kai Li, Hsiaopei Mok, Li Cao, Xiaoqing Chen, Jiali Lin, Guangnan Wei, Yingzhi Li, Yuchen Zhang, Charles M. Balch, Ning Liao

Open Access 01.12.2022 | Research article

Adiposity and risk of prostate cancer death: a prospective analysis in UK Biobank and meta-analysis of published studies
Aurora Perez-Cornago, Yashvee Dunneram, Eleanor L. Watts, Timothy J. Key, Ruth C. Travis

Open Access 01.12.2022 | Research article

Etiological spectrum of persistent fever in the tropics and predictors of ubiquitous infections: a prospective four-country study with pooled analysis
Emmanuel Bottieau, Lukas Van Duffel, Sayda El Safi, Kanika Deshpande Koirala, Basudha Khanal, Suman Rijal, Narayan Raj Bhattarai, Thong Phe, Kruy Lim, Deby Mukendi, Jean-Roger Lilo Kalo, Pascal Lutumba, Barbara Barbé, Jan Jacobs, Marjan Van Esbroeck, Nikki Foqué, Achilleas Tsoumanis, Philippe Parola, Cedric P. Yansouni, Marleen Boelaert, Kristien Verdonck, François Chappuis

Open Access 01.12.2022 | Research article

Prospective association of dietary soy and fibre intake with puberty timing: a cohort study among Chinese children
Jingyuan Xiong, Yujie Xu, Xueting Liu, Xiaoyu Wang, Shufang Shan, M. James C. Crabbe, Li Zhao, He Fang, Guo Cheng

Open Access 01.12.2022 | COVID-19 | Research article

CoronaVac vaccine is effective in preventing symptomatic and severe COVID-19 in pregnant women in Brazil: a test-negative case-control study
Enny S. Paixao, Kerry L. M. Wong, Flavia Jôse Oliveira Alves, Vinicius de Araújo Oliveira, Thiago Cerqueira-Silva, Juracy Bertoldo Júnior, Tales Mota Machado, Elzo Pereira Pinto Junior, Viviane S. Boaventura, Gerson O. Penna, Guilherme Loureiro Werneck, Laura C. Rodrigues, Neil Pearce, Mauricio L. Barreto, Manoel Barral-Netto

Open Access 01.12.2022 | COVID-19 | Research article

The UK Coronavirus Job Retention Scheme and diet, physical activity, and sleep during the COVID-19 pandemic: evidence from eight longitudinal population surveys
Bożena Wielgoszewska, Jane Maddock, Michael J. Green, Giorgio Di Gessa, Sam Parsons, Gareth J. Griffith, Jazz Croft, Anna J. Stevenson, Charlotte Booth, Richard J. Silverwood, David Bann, Praveetha Patalay, Alun D. Hughes, Nishi Chaturvedi, Laura D. Howe, Emla Fitzsimons, Srinivasa Vittal Katikireddi, George B. Ploubidis

Open Access 01.12.2022 | Research article

Ketone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway
Chongyang Huang, Jun Wang, Hongbin Liu, Ruo Huang, Xinwen Yan, Mengyao Song, Gao Tan, Fachao Zhi

Open Access 01.12.2022 | Research article

Ethnic differences in cardiovascular risk: examining differential exposure and susceptibility to risk factors
Frederick K. Ho, Stuart R. Gray, Paul Welsh, Jason M. R. Gill, Naveed Sattar, Jill P. Pell, Carlos Celis-Morales

Open Access 01.12.2022 | Research article

Barriers to management of opioid withdrawal in hospitals in England: a document analysis of hospital policies on the management of substance dependence
Magdalena Harris, Adam Holland, Dan Lewer, Michael Brown, Niamh Eastwood, Gary Sutton, Ben Sansom, Gabby Cruickshank, Molly Bradbury, Isabelle Guest, Jenny Scott

Open Access 01.12.2022 | Research article

Predictive performance of a competing risk cardiovascular prediction tool CRISK compared to QRISK3 in older people and those with comorbidity: population cohort study
Shona J. Livingstone, Bruce Guthrie, Peter T. Donnan, Alexander Thompson, Daniel R. Morales

Open Access 01.12.2022 | Research article

Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models: implications for risk stratification
Peh Joo Ho, Weang Kee Ho, Alexis J. Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong, Wei Sean Yong, Chin Mui Seah, Siau Wei Tang, Celene Wei Qi Ng, Zhiyan Yan, Jung Ah Lee, Kartini Rahmat, Tania Islam, Tiara Hassan, Mei-Chee Tai, Chiea Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Xueling Sim, Alison M. Dunning, Manjeet K. Bolla, Antonis C. Antoniou, Soo-Hwang Teo, Jingmei Li, Mikael Hartman

Open Access 01.12.2022 | Research article

Impact of prenatal tobacco smoking on infant telomere length trajectory and ADHD symptoms at 18 months: a longitudinal cohort study
Meghan P. Howell, Christopher W. Jones, Cade A. Herman, Celia V. Mayne, Camilo Fernandez, Katherine P. Theall, Kyle C. Esteves, Stacy S. Drury

Open Access 01.12.2022 | Research article

Apatinib in patients with recurrent or metastatic thymic epithelial tumor: a single-arm, multicenter, open-label, phase II trial
Zhengbo Song, Guangyuan Lou, Yina Wang, Zhiping Yang, Wenxian Wang, Yongling Ji, Shiqing Chen, Chunwei Xu, Xiao Hu, Yiping Zhang

Open Access 01.12.2022 | Research article

Phase II study of anlotinib in combination with oxaliplatin and capecitabine for patients with RAS/BRAF wild-type metastatic colorectal adenocarcinoma as the first-line therapy
Yue Liu, Qian Xiao, Jinjie He, Hanguang Hu, Jinlin Du, Yuping Zhu, Jiaqi Chen, Zhuo Liu, Jianping Wang, Lifeng Sun, Dong Xu, Jun Li, Xiujun Liao, Jianwei Wang, Yibo Cai, Cheng Cai, Zhekang Jin, Liuhong Wang, Ying Yuan, Kefeng Ding

Open Access 01.12.2022 | Research article

Predicting the earliest deviation in weight gain in the course towards manifest overweight in offspring exposed to obesity in pregnancy: a longitudinal cohort study
Delphina Gomes, Lien Le, Sarah Perschbacher, Nikolaus A. Haas, Heinrich Netz, Uwe Hasbargen, Maria Delius, Kristin Lange, Uta Nennstiel, Adelbert A. Roscher, Ulrich Mansmann, Regina Ensenauer

Open Access 01.12.2022 | Research article

Opening up safely: public health system requirements for ongoing COVID-19 management based on evaluation of Australia’s surveillance system performance
Kamalini Lokuge, Katina D’Onise, Emily Banks, Tatum Street, Sydney Jantos, Mohana Baptista, Kathryn Glass

Open Access 01.12.2022 | Research article

Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood
Júlia Vallvé-Juanico, Ashley F. George, Sushmita Sen, Reuben Thomas, Min-Gyoung Shin, Divyashree Kushnoor, Joshua J. Vásquez, Kim Chi Vo, Juan C. Irwin, Nadia R. Roan, Alexis J. Combes, Linda C. Giudice

Open Access 01.12.2022 | Research article

Predictive value of circulating NMR metabolic biomarkers for type 2 diabetes risk in the UK Biobank study
Fiona Bragg, Eirini Trichia, Diego Aguilar-Ramirez, Jelena Bešević, Sarah Lewington, Jonathan Emberson

Open Access 01.12.2022 | Research article

Reliability analysis of exonic-breakpoint fusions identified by DNA sequencing for predicting the efficacy of targeted therapy in non-small cell lung cancer
Weihua Li, Rui Wan, Lei Guo, Geyun Chang, Dong Jiang, Lin Meng, Jianming Ying

Open Access 01.12.2022 | Research article

Is glycaemic control associated with dietary patterns independent of weight change in people newly diagnosed with type 2 diabetes? Prospective analysis of the Early-ACTivity-In-Diabetes trial
James Garbutt, C. England, A. G. Jones, R. C. Andrews, R. Salway, L. Johnson

Open Access 01.12.2022 | Research article

A deep learning approach identifies new ECG features in congenital long QT syndrome
Simona Aufiero, Hidde Bleijendaal, Tomas Robyns, Bert Vandenberk, Christian Krijger, Connie Bezzina, Aeilko H. Zwinderman, Arthur A. M. Wilde, Yigal M. Pinto

Open Access 01.12.2022 | Research article

Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of fragile X syndrome
Sahar Javadi, Yue Li, Jie Sheng, Lucy Zhao, Yao Fu, Daifeng Wang, Xinyu Zhao

Open Access 26.04.2022 | COVID-19 | Research article

Survival among people hospitalized with COVID-19 in Switzerland: a nationwide population-based analysis
Nanina Anderegg, Radoslaw Panczak, Matthias Egger, Nicola Low, Julien Riou

Open Access 01.12.2022 | Research article

Environmental pesticide exposure and non-Hodgkin lymphoma survival: a population-based study
Christina Poh, John D. McPherson, Joseph Tuscano, Qian Li, Arti Parikh-Patel, Christoph F. A. Vogel, Myles Cockburn, Theresa Keegan

Open Access 01.12.2022 | Research article

Imagery ability assessments: a cross-disciplinary systematic review and quality evaluation of psychometric properties
Zorica Suica, Frank Behrendt, Szabina Gäumann, Ulrich Gerth, Arno Schmidt-Trucksäss, Thierry Ettlin, Corina Schuster-Amft

Open Access 30.04.2022 | COVID-19 | Forum

The COVID-19 pandemic in the African continent
Godfrey Bwire, Alex Riolexus Ario, Patricia Eyu, Felix Ocom, Joseph F. Wamala, Kwadwo A. Kusi, Latif Ndeketa, Kondwani C. Jambo, Rhoda K. Wanyenze, Ambrose O. Talisuna

Open Access 01.12.2022 | Research article

Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study
Junyi Xin, Xia Jiang, Shuai Ben, Qianyu Yuan, Li Su, Zhengdong Zhang, David C. Christiani, Mulong Du, Meilin Wang

Open Access 01.12.2022 | Research article

Comprehensive and integrative analyses identify TYW5 as a schizophrenia risk gene
Chengcheng Zhang, Xiaojing Li, Liansheng Zhao, Rong Liang, Wei Deng, Wanjun Guo, Qiang Wang, Xun Hu, Xiangdong Du, Pak Chung Sham, Xiongjian Luo, Tao Li

Open Access 01.12.2022 | Research article

ctDNA-adjusted bTMB as a predictive biomarker for patients with NSCLC treated with PD-(L)1 inhibitors
Wei Nie, Zhi-Jie Wang, Kai Zhang, Bing Li, Yi-Ran Cai, Feng-Cai Wen, Ding Zhang, Yue-Zong Bai, Xue-Yan Zhang, Shu-Yuan Wang, Lei Cheng, Hua Zhong, Li Liu, Jie Wang, Bao-Hui Han

Open Access 01.12.2022 | Research article

Temporal relationship among adiposity, gut microbiota, and insulin resistance in a longitudinal human cohort
Kui Deng, Menglei Shuai, Zheqing Zhang, Zengliang Jiang, Yuanqing Fu, Luqi Shen, Ju-Sheng Zheng, Yu-ming Chen

Open Access 01.12.2022 | Research article

Leaving no one behind: targeting mobile and migrant populations with health interventions for disease elimination—a descriptive systematic review
Molly W Adams, Elizabeth G Sutherland, Erin L Eckert, Khalida Saalim, Richard Reithinger

Open Access 01.12.2022 | Research article

Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections
Sanjeevan Jahagirdar, Lorna Morris, Nirupama Benis, Oddvar Oppegaard, Mattias Svenson, Ole Hyldegaard, Steinar Skrede, Anna Norrby-Teglund, Vitor A. P. Martins dos Santos, Edoardo Saccenti, INFECT Study group

Open Access 01.12.2022 | Research article

Evaluating agreement between bodies of evidence from randomized controlled trials and cohort studies in medical research: a meta-epidemiological study
Nils Bröckelmann, Sara Balduzzi, Louisa Harms, Jessica Beyerbach, Maria Petropoulou, Charlotte Kubiak, Martin Wolkewitz, Joerg J. Meerpohl, Lukas Schwingshackl

Open Access 01.12.2022 | Research article

Palbociclib-based high-throughput combination drug screening identifies synergistic therapeutic options in HPV-negative head and neck squamous cell carcinoma
Ziyue Gu, Chaoji Shi, Jiayi Li, Yong Han, Bao Sun, Wuchang Zhang, Jing Wu, Guoyu Zhou, Weimin Ye, Jiang Li, Zhiyuan Zhang, Rong Zhou

Open Access 01.12.2022 | Research article

Effectiveness of a digital intervention versus alcohol information for online help-seekers in Sweden: a randomised controlled trial
Marcus Bendtsen, Katarina Åsberg, Jim McCambridge

Open Access 01.12.2022 | Registered report

Data-sharing and re-analysis for main studies assessed by the European Medicines Agency—a cross-sectional study on European Public Assessment Reports
Maximilian Siebert, Jeanne Gaba, Alain Renault, Bruno Laviolle, Clara Locher, David Moher, Florian Naudet

Open Access 01.12.2022 | Research article

Associations of face-to-face and non-face-to-face social isolation with all-cause and cause-specific mortality: 13-year follow-up of the Guangzhou Biobank Cohort study
Jiao Wang, Wei Sen Zhang, Chao Qiang Jiang, Feng Zhu, Ya Li Jin, Kar Keung Cheng, Tai Hing Lam, Lin Xu

Open Access 01.12.2022 | Correction

Correction: Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy
Justyna Mączyńska, Florian Raes, Chiara Da Pieve, Stephen Turnock, Jessica K. R. Boult, Julia Hoebart, Marcin Niedbala, Simon P. Robinson, Kevin J. Harrington, Wojciech Kaspera, Gabriela Kramer-Marek

Open Access 01.12.2022 | Correction

Correction: HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis
Xiaoyu Xie, Huanran Lv, Chenxi Liu, Xiaonan Su, Zhen Yu, Shouyang Song, Hongjun Bian, Miaomiao Tian, Chengyong Qin, Jianni Qi, Qiang Zhu

Open Access 05.05.2022 | COVID-19 | Research article

Broad humoral and cellular immunity elicited by one-dose mRNA vaccination 18 months after SARS-CoV-2 infection
Chang Kyung Kang, Hyun Mu Shin, Pyoeng Gyun Choe, Jiyoung Park, Jisu Hong, Jung Seon Seo, Yung Hie Lee, Euijin Chang, Nam Joong Kim, Minji Kim, Yong-Woo Kim, Hang-Rae Kim, Chang-Han Lee, Jun-Young Seo, Wan Beom Park, Myoung-don Oh

Open Access 01.12.2022 | Research article

Prioritising attributes for tuberculosis preventive treatment regimens: a modelling analysis
Juan F. Vesga, Christian Lienhardt, Placide Nsengiyumva, Jonathon R. Campbell, Olivia Oxlade, Saskia den Boon, Dennis Falzon, Kevin Schwartzman, Gavin Churchyard, Nimalan Arinaminpathy

Open Access 01.12.2022 | Research article

Ten years of tracking mental health in refugee primary health care settings: an updated analysis of data from UNHCR’s Health Information System (2009–2018)
Shoshanna L. Fine, Jeremy C. Kane, Paul B. Spiegel, Wietse A. Tol, Peter Ventevogel

Open Access 01.12.2022 | Research article

Structured reporting to improve transparency of analyses in prognostic marker studies
Willi Sauerbrei, Tim Haeussler, James Balmford, Marianne Huebner

Open Access 01.12.2022 | Research article

Temporal trajectories of important diseases in the life course and premature mortality in the UK Biobank
Xianwen Shang, Xueli Zhang, Yu Huang, Zhuoting Zhu, Xiayin Zhang, Shunming Liu, Jiahao Liu, Shulin Tang, Wei Wang, Honghua Yu, Zongyuan Ge, Mingguang He

Open Access 01.12.2022 | Research article

The impact of medication reviews by general practitioners on psychotropic drug use and behavioral and psychological symptoms in home-dwelling people with dementia: results from the multicomponent cluster randomized controlled LIVE@Home.Path trial
Marie H. Gedde, Bettina S. Husebo, Janne Mannseth, Mala Naik, Geir Selbaek, Maarja Vislapuu, Line Iden Berge

Open Access 01.12.2022 | Research article

Systematic analysis of IL-6 as a predictive biomarker and desensitizer of immunotherapy responses in patients with non-small cell lung cancer
Chengming Liu, Lu Yang, Haiyan Xu, Sufei Zheng, Zhanyu Wang, Sihui Wang, Yaning Yang, Shuyang Zhang, Xiaoli Feng, Nan Sun, Yan Wang, Jie He

Open Access 01.12.2022 | Research article

Genetic susceptibility, screen-based sedentary activities and incidence of coronary heart disease
Youngwon Kim, Shiu Lun Au Yeung, Stephen J. Sharp, Mengyao Wang, Haeyoon Jang, Shan Luo, Soren Brage, Katrien Wijndaele

Open Access 01.12.2022 | Research article

Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth
Ya-nan Zhu, Xiao-wen Gan, Fan Pan, Xiao-tian Ni, Leslie Myatt, Wang-sheng Wang, Kang Sun

Open Access 01.12.2022 | Research article

Intermittent screening and treatment for malaria complementary to routine immunisation in the first year of life in Papua, Indonesia: a cluster randomised superiority trial
Jeanne Rini Poespoprodjo, Hafiidhaturrahmah, Novita Sariyanti, Ratni Indrawanti, Alistair R. D. McLean, Julie A. Simpson, Enny Kenangalem, Faustina Helena Burdam, Rintis Noviyanti, Leily Trianty, Chairunisa Fadhilah, Yati Soenarto, Ric N. Price

Open Access 01.12.2022 | Research article

Associations of handgrip strength with morbidity and all-cause mortality of cardiometabolic multimorbidity
Yanqiang Lu, Guochen Li, Pietro Ferrari, Heinz Freisling, Yanan Qiao, Luying Wu, Liping Shao, Chaofu Ke

Open Access 01.12.2022 | Research article

Intake of whole grain foods and risk of coronary heart disease in US men and women
Yang Hu, Walter C. Willett, Jo Ann E. Manson, Bernard Rosner, Frank B. Hu, Qi Sun

Open Access 01.12.2022 | Research article

Comparing efficacy and safety in catheter ablation strategies for atrial fibrillation: a network meta-analysis
Emmanouil Charitakis, Silvia Metelli, Lars O. Karlsson, Antonios P. Antoniadis, Konstantinos D. Rizas, Ioan Liuba, Henrik Almroth, Anders Hassel Jönsson, Jonas Schwieler, Dimitrios Tsartsalis, Skevos Sideris, Elena Dragioti, Nikolaos Fragakis, Anna Chaimani

Open Access 01.12.2022 | Research article

Role of diet in stroke incidence: an umbrella review of meta-analyses of prospective observational studies
Na Guo, Ying Zhu, Dandan Tian, Yating Zhao, Chenguang Zhang, Changqing Mu, Chen Han, Ruixia Zhu, Xu Liu

Open Access 01.12.2022 | Research article

The effectiveness of the Structured Health Intervention For Truckers (SHIFT): a cluster randomised controlled trial (RCT)
Stacy A. Clemes, Veronica Varela-Mato, Danielle H. Bodicoat, Cassandra L. Brookes, Yu-Ling Chen, Charlotte L. Edwardson, Laura J. Gray, Amber J. Guest, Vicki Johnson, Fehmidah Munir, Nicola J. Paine, Gerry Richardson, Katharina Ruettger, Mohsen Sayyah, Aron Sherry, Ana Suazo Di Paola, Jacqui Troughton, Thomas Yates, James A. King

Open Access 01.12.2022 | COVID-19 | Research article

An assessment of the vaccination of school-aged children in England against SARS-CoV-2
Matt J. Keeling, Sam E. Moore

Open Access 01.12.2022 | Research article

Subsequent treatments beyond progression on osimertinib in EGFR-mutated NSCLC and leptomeningeal metastases
Mei-Mei Zheng, Yang-Si Li, Hai-Yan Tu, Hao Sun, Kai Yin, Ben-Yuan Jiang, Jin-Ji Yang, Xu-Chao Zhang, Qing Zhou, Chong-Rui Xu, Zhen Wang, Hua-Jun Chen, De-Xiang Zhou, Yi-Long Wu

Open Access 01.12.2022 | Research article

Intelligence outcome of pediatric intensive care unit survivors: a systematic meta-analysis and meta-regression
Eleonore S. V. de Sonnaville, Marsh Kӧnigs, Ouke van Leijden, Hennie Knoester, Job B. M. van Woensel, Jaap Oosterlaan

Open Access 24.05.2022 | COVID-19 | Research article

Effectiveness of COVID-19 vaccines against SARS-CoV-2 variants of concern: a systematic review and meta-analysis
Baoqi Zeng, Le Gao, Qingxin Zhou, Kai Yu, Feng Sun

Open Access 01.12.2022 | COVID-19 | Research article

Time trends in social contacts of individuals according to comorbidity and vaccination status, before and during the COVID-19 pandemic
Aurélie Godbout, Mélanie Drolet, Myrto Mondor, Marc Simard, Chantal Sauvageau, Gaston De Serres, Marc Brisson

Open Access 01.12.2022 | Research article

Adiposity and grip strength: a Mendelian randomisation study in UK Biobank
Snehal M. Pinto Pereira, Victoria Garfield, Aliki-Eleni Farmaki, David J. Tomlinson, Thomas Norris, Ghazaleh Fatemifar, Spiros Denaxas, Chris Finan, Rachel Cooper

Open Access 01.12.2022 | Research article

Projecting vaccine demand and impact for emerging zoonotic pathogens
Anita Lerch, Quirine A. ten Bosch, Maïna L’Azou Jackson, Alison A. Bettis, Mauro Bernuzzi, Georgina A. V. Murphy, Quan M. Tran, John H. Huber, Amir S. Siraj, Gebbiena M. Bron, Margaret Elliott, Carson S. Hartlage, Sojung Koh, Kathyrn Strimbu, Magdalene Walters, T. Alex Perkins, Sean M. Moore

Open Access 01.12.2022 | Research article

Associations of genetic risk, BMI trajectories, and the risk of non-small cell lung cancer: a population-based cohort study
Dongfang You, Danhua Wang, Yaqian Wu, Xin Chen, Fang Shao, Yongyue Wei, Ruyang Zhang, Theis Lange, Hongxia Ma, Hongyang Xu, Zhibin Hu, David C. Christiani, Hongbing Shen, Feng Chen, Yang Zhao

Open Access 01.12.2022 | Research article

Gut microbiota signatures of long-term and short-term plant-based dietary pattern and cardiometabolic health: a prospective cohort study
Zelei Miao, Wenwen Du, Congmei Xiao, Chang Su, Wanglong Gou, Luqi Shen, Jiguo Zhang, Yuanqing Fu, Zengliang Jiang, Zhihong Wang, Xiaofang Jia, Ju-Sheng Zheng, Huijun Wang

Open Access 01.12.2022 | Research article

Observational study of population genomic screening for variants associated with endocrine tumor syndromes in a large, healthcare-based cohort
Juliann M. Savatt, Nicole M. Ortiz, Gretchen M. Thone, Whitney S. McDonald, Melissa A. Kelly, Alexander S. F. Berry, Madiha M. Alvi, Miranda L. G. Hallquist, Jennifer Malinowski, Nicholas C. Purdy, Marc S. Williams, Amy C. Sturm, Adam H. Buchanan

Open Access 01.12.2022 | Research article

Targeted RNA next generation sequencing analysis of cervical smears can predict the presence of hrHPV-induced cervical lesions
Karolina M. Andralojc, Duaa Elmelik, Menno Rasing, Bernard Pater, Albert G. Siebers, Ruud Bekkers, Martijn A. Huynen, Johan Bulten, Diede Loopik, Willem J. G. Melchers, William P. J. Leenders

Open Access 01.12.2022 | Research article

Biological aging mediates the associations between urinary metals and osteoarthritis among U.S. adults
Li Chen, Ying Zhao, Fangqu Liu, Huimin Chen, Tianqi Tan, Ping Yao, Yuhan Tang

Open Access 01.12.2022 | Research article

Clinical benefit of systolic blood pressure within the target range among patients with or without diabetes mellitus: a propensity score-matched analysis of two randomized clinical trials
Chao Li, Kangyu Chen, Guoshuai Shi, Rui Shi, Zhenqiang Wu, Xiaodan Yuan, Vicky Watson, Zhixin Jiang, Hui Mai, Tian Yang, Duolao Wang, Tao Chen

Open Access 01.12.2022 | Research article

Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants
Maria Carolina Borges, Philip C. Haycock, Jie Zheng, Gibran Hemani, Michael V. Holmes, George Davey Smith, Aroon D. Hingorani, Deborah A. Lawlor

Open Access 01.12.2022 | Research article

Identification of novel proteins for lacunar stroke by integrating genome-wide association data and human brain proteomes
Chengcheng Zhang, Fengqin Qin, Xiaojing Li, Xiangdong Du, Tao Li

Open Access 01.12.2022 | Research article

Length of initial prescription at hospital discharge and long-term medication adherence for elderly, post-myocardial infarction patients: a population-based interrupted time series study
J. D. Schwalm, Noah M. Ivers, Zachary Bouck, Monica Taljaard, Madhu K. Natarajan, Francis Nguyen, Waseem Hijazi, Kednapa Thavorn, Lisa Dolovich, Tara McCready, Erin O’Brien, Jeremy M. Grimshaw

Open Access 01.12.2022 | Research article

Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysis
Ping Guo, Weiming Gong, Yuanming Li, Lu Liu, Ran Yan, Yanjun Wang, Yanan Zhang, Zhongshang Yuan

Open Access 01.12.2022 | COVID-19 | Research article

Serological study of CoronaVac vaccine and booster doses in Chile: immunogenicity and persistence of anti-SARS-CoV-2 spike antibodies
Leonardo Vargas, Nicolás Valdivieso, Fabián Tempio, Valeska Simon, Daniela Sauma, Lucía Valenzuela, Caroll Beltrán, Loriana Castillo-Delgado, Ximena Contreras-Benavides, Mónica L. Acevedo, Johanna Acevedo, Rafael I. Gonzalez, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Mario Rosemblatt, Mercedes Lopez, Fabiola Osorio, María Rosa Bono

Open Access 01.12.2022 | Research article

Plasma neurofilament light and its association with all-cause mortality risk among urban middle-aged men and women
May A. Beydoun, Nicole Noren Hooten, Jordan Weiss, Hind A. Beydoun, Sharmin Hossain, Michele K. Evans, Alan B. Zonderman

Open Access 01.12.2022 | Research article

International surveillance study in acute spinal cord injury confirms viability of multinational clinical trials
Lucie Bourguignon, Bobo Tong, Fred Geisler, Martin Schubert, Frank Röhrich, Marion Saur, Norbert Weidner, Rüdiger Rupp, Yorck-Bernhard B. Kalke, Rainer Abel, Doris Maier, Lukas Grassner, Harvinder S. Chhabra, Thomas Liebscher, Jacquelyn J. Cragg, John Kramer, Armin Curt, Catherine R. Jutzeler, EMSCI study group

Open Access 01.12.2022 | COVID-19 | Research article

Is living in a household with children associated with SARS-CoV-2 seropositivity in adults? Results from the Swiss national seroprevalence study Corona Immunitas
Jacob Blankenberger, Marco Kaufmann, Emiliano Albanese, Rebecca Amati, Daniela Anker, Anne-Linda Camerini, Patricia Chocano-Bedoya, Stéphane Cullati, Alexia Cusini, Jan Fehr, Erika Harju, Philipp Kohler, Susi Kriemler, Gisela Michel, Nicolas Rodondi, Pierre-Yves Rodondi, Alexandre Speierer, Stefano Tancredi, Milo A. Puhan, Christian R. Kahlert, on behalf of the Corona Immunitas Research Group

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