Skip to main content
main-content

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

BMC Cancer 1/2018

Body mass index and lung cancer risk in never smokers: a meta-analysis

Zeitschrift:
BMC Cancer > Ausgabe 1/2018
Autoren:
Hongjun Zhu, Shuanglin Zhang
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12885-018-4543-y) contains supplementary material, which is available to authorized users.

Abstract

Background

Obesity is found to increase the risk of most cancer types, but reduce lung cancer risk in many studies. However, the association between obesity and lung cancer is still controversial, mainly owing to the confounding effect of smoking.

Methods

Eligible studies were identified from electric databases to July 1, 2017. Relevant data were extracted and pooled using random-effects models; dose-response and subgroup analyses were also performed.

Results

Twenty-nine studies with more than 10,000 lung cancer cases in15 million never smokers were included. Compared with normal weight, the summary relative risk (RR) was 0.77(95% confidence interval [CI]: 0.68–0.88, P < 0.01) for excess body weight (body mass index [BMI] ≥ 25 kg/m2). An inverse linear dose-response relationship was observed between BMI and lung cancer risk in never smokers, with an RR of 0.89(95% CI: 0.84–0.95, P < 0.01) per 5 kg/m2 increment in BMI. The results remained stable in most subgroup analyses. However, when stratified by sex, a significant inverse association existed in women but not in men. Similar results were found in analyses for other categories of BMI.

Conclusion

Our results indicate that higher BMI is associated with lower lung cancer risk in never smokers.
Zusatzmaterial
Additional file 1: Table S1. Characteristics of studies included in the meta-analysis of obesity and lung cancer risk in non-smokers. (DOCX 88 kb)
12885_2018_4543_MOESM1_ESM.docx
Additional file 2: Table S2. Quality scores of the cohort studies included in the meta-analysis, assessed by the Newcastle-Ottawa scale. (DOCX 20 kb)
12885_2018_4543_MOESM2_ESM.docx
Additional file 3: Table S3. Quality scores of the case-control studies included in the meta-analysis, assessed by the Newcastle-Ottawa scale. (DOCX 18 kb)
12885_2018_4543_MOESM3_ESM.docx
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2018

BMC Cancer 1/2018 Zur Ausgabe


 

Neu im Fachgebiet Onkologie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Onkologie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise