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05.01.2022 | Original Paper

Body mass index and risk of clostridioides difficile infection: a systematic review and meta-analysis

verfasst von: Nipith Charoenngam, Ben Ponvilawan, Jerapas Thongpiya, Pitchaporn Yingchoncharoen, Thanat Chaikijurajai, Natapat Chaisidhivej, Caroline M. Apovian, Patompong Ungprasert

Erschienen in: Infection | Ausgabe 3/2022

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Abstract

Objective

To comprehensively investigate the association between obesity/high body mass index (BMI) and risk of Clostridioides difficile infection (CDI) using systematic review and meta-analysis.

Methods

Potentially eligible studies were identified from Medline and EMBASE databases from inception to February 2021 using search strategy consisting of terms for “Body Mass Index” and “Clostridioides Difficile”. We only included studies that consist of a group of individuals with CDI and another group without CDI. Then, the studies must report their BMI or history of obesity. Odds ratio (OR) and 95% CIs of the association between BMI status and CDI were retrieved from each study and combined using the generic inverse variance method. Funnel plot was used to assess publication bias.

Results

A total of 4609 articles were identified. After two rounds of systematic review, 17 studies met the eligibility criteria and were included into the meta-analysis. Pooled analysis showed that individuals with high BMI had a significantly decreased odds of CDI with the pooled OR of 0.88 (95% CI 0.80–0.97). This meta-analysis had high statistical heterogeneity with I² of 74%. Funnel plot was symmetric, which was not suggestive of presence of publication bias.

Conclusion

This meta-analysis revealed a significant negative association between BMI and CDI.

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Titel: Body mass index and risk of clostridioides difficile infection: a systematic review and meta-analysis
verfasst von: Nipith Charoenngam
Ben Ponvilawan
Jerapas Thongpiya
Pitchaporn Yingchoncharoen
Thanat Chaikijurajai
Natapat Chaisidhivej
Caroline M. Apovian
Patompong Ungprasert
Publikationsdatum: 05.01.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Infection / Ausgabe 3/2022
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI: https://doi.org/10.1007/s15010-021-01749-9

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Body mass index and risk of clostridioides difficile infection: a systematic review and meta-analysis