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01.06.2010 | Colorectal Cancer | Ausgabe 6/2010

Annals of Surgical Oncology 6/2010

Body Mass Index does not Affect Postoperative Morbidity and Oncologic Outcomes of Total Mesorectal Excision for Rectal Adenocarcinoma

Zeitschrift:
Annals of Surgical Oncology > Ausgabe 6/2010
Autoren:
MBBS Nikiforos Ballian, MD Brett Yamane, PhD Glen Leverson, MD Bruce Harms, MD Charles P. Heise, MD Eugene F. Foley, MD, PhD Gregory D. Kennedy

Abstract

Introduction

Obesity adds to the technical difficulty of colorectal surgery and is a risk factor for postoperative complications. We hypothesized that obese patients have increased morbidity and poor oncologic outcomes after proctectomy for rectal adenocarcinoma.

Methods

Adult patients undergoing total mesorectal excision (TME) for rectal adenocarcinoma at a tertiary referral center were retrospectively identified from a prospectively maintained database. Operative characteristics, postoperative complication rates, and oncologic outcomes were compared in patients with BMI ≥ 30 kg/m2 and BMI < 30 kg/m2.

Results

Between 1997 and 2009, 254 patients underwent proctectomy for rectal adenocarcinoma, of whom 27% were obese. There were no significant differences in demographics, comorbidities or preoperative oncologic characteristics between obese and nonobese groups. Patients with BMI ≥ 30 kg/m2 had longer operative times (p = 0.04) and higher intraoperative blood loss (p < 0.001) but comparable postoperative complication rates (p = 0.80), number of lymph nodes retrieved (p = 0.57), margin-negative resections (p = 0.44), and disease-free survival (p = 0.11). Obese patients had longer overall survival (p = 0.05). Tumor stage was the only variable associated with disease-free (p < 0.001) and overall survival (p < 0.001).

Conclusion

Despite increased technical difficulty of resection, obesity does not increase the risk of postoperative morbidity or adversely affect oncologic outcomes after total mesorectal excision of rectal adenocarcinoma.

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