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Journal of Cancer Research and Clinical Oncology

Erschienen in:

04.04.2016 | Review – Cancer Research

Bone morphogenetic protein signaling in musculoskeletal cancer

verfasst von: Myrto Bami, Andreas F. Mavrogenis, Andrea Angelini, Mandy Milonaki, Evanthia Mitsiokapa, Dimitrios Stamoulis, Panayotis N. Soucacos

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 10/2016

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Abstract

Purpose

Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-β (TGF-β) superfamily of proteins; they were initially named after their ability to induce ectopic bone formation. Published studies have proved BMPs’ role in a variety of biological processes such as embryogenesis and patterning of body axes, and maintaining adult tissue homeostasis. Other studies have focused on BMPs properties, functions and possible involvement in skeletal diseases, including cancer.

Methods

A literature search mainly paying attention to the role of BMPs in musculoskeletal tumors was performed in electronic databases.

Results

This article discusses BMPs synthesis and signaling, and summarizes their prominent roles in the skeletal system for the differentiation of osteoblasts, osteocytes and chondrocytes.

Conclusions

The review emphasizes on the role of BMP signaling in the initiation and progression of musculoskeletal cancer.

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Titel: Bone morphogenetic protein signaling in musculoskeletal cancer
verfasst von: Myrto Bami
Andreas F. Mavrogenis
Andrea Angelini
Mandy Milonaki
Evanthia Mitsiokapa
Dimitrios Stamoulis
Panayotis N. Soucacos
Publikationsdatum: 04.04.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 10/2016
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-016-2149-9

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Bone morphogenetic protein signaling in musculoskeletal cancer

Abstract

Purpose

Methods

Results

Conclusions

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Purpose

Methods

Results

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