Erschienen in:
13.07.2020 | Brief Report
Bordetella pertussis DNA detected in a tracheostomized child blood before seroconversion
verfasst von:
Flora Marzia Liotti, Giulia De Angelis, Domenico Speziale, Grazia Angela Morandotti, Orazio Genovese, Maurizio Sanguinetti, Brunella Posteraro
Erschienen in:
European Journal of Clinical Microbiology & Infectious Diseases
|
Ausgabe 1/2021
Einloggen, um Zugang zu erhalten
Excerpt
Despite a widespread pertussis immunization in childhood, the
Bordetella pertussis infection (BPI)—including pertussis (i.e. whooping cough)—has risen in many world regions [
1], and factors contributing to resurgence (or emergence) of BPI include improved diagnostics [
2]. Tracheostomy is a common therapeutic practice for infants with respiratory disturbances, but it inevitably creates a stressful environment in the child’s throat. This environment may hamper the thriving of
B. pertussis in the upper respiratory tract [
3], which is yet the preferred colonization site of
B. pertussis and other
Bordetella species, such as
Bordetella parapertussis,
Bordetella bronchiseptica and
Bordetella holmesii. Unlike
B. holmesii [
4], the tendency to invade the respiratory epithelium in the nasopharynx and trachea and, consequently, to reach the bloodstream and/or the lung tissue is low in
B. pertussis [
5]. …
