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Erschienen in: Neuroradiology 10/2016

20.07.2016 | Paediatric Neuroradiology

Brain imaging with synthetic MR in children: clinical quality assessment

verfasst von: Aaron M. Betts, James L. Leach, Blaise V. Jones, Bin Zhang, Suraj Serai

Erschienen in: Neuroradiology | Ausgabe 10/2016

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Abstract

Introduction

Synthetic magnetic resonance imaging is a quantitative imaging technique that measures inherent T1-relaxation, T2-relaxation, and proton density. These inherent tissue properties allow synthesis of various imaging sequences from a single acquisition. Clinical use of synthetic MR imaging has been described in adult populations. However, use of synthetic MR imaging has not been previously reported in children. The purpose of this study is to report our assessment of diagnostic image quality using synthetic MR imaging in children.

Methods

Synthetic MR acquisition was obtained in a sample of children undergoing brain MR imaging. Image quality assessments were performed on conventional and synthetic T1-weighted, T2-weighted, and FLAIR images. Standardized linear measurements were performed on conventional and synthetic T2 images. Estimates of patient age based upon myelination patterns were also performed.

Results

Conventional and synthetic MR images were evaluated on 30 children. Using a 4-point assessment scale, conventional imaging performed better than synthetic imaging for T1-weighted, T2-weighted, and FLAIR images. When the assessment was simplified to a dichotomized scale, the conventional and synthetic T1-weighted and T2-weighted images performed similarly. However, the superiority of conventional FLAIR images persisted in the dichotomized assessment. There were no statistically significant differences between linear measurements made on T2-weighted images. Estimates of patient age based upon pattern of myelination were also similar between conventional and synthetic techniques.

Conclusion

Synthetic MR imaging may be acceptable for clinical use in children. However, users should be aware of current limitations that could impact clinical utility in the software version used in this study.
Literatur
2.
Zurück zum Zitat Bobman SA, Riederer SJ, Lee JN, Suddarth SA, Wang HZ, Drayer BP, MacFall JR (1985) Cerebral magnetic resonance image synthesis. AJNR Am J Neuroradiol 6(2):265–269PubMed Bobman SA, Riederer SJ, Lee JN, Suddarth SA, Wang HZ, Drayer BP, MacFall JR (1985) Cerebral magnetic resonance image synthesis. AJNR Am J Neuroradiol 6(2):265–269PubMed
3.
Zurück zum Zitat Riederer SJ, Lee JN, Farzaneh F, Wang HZ, Wright RC (1986) Magnetic resonance image synthesis. Clinical implementation. Acta Radiol Suppl 369:466–468PubMed Riederer SJ, Lee JN, Farzaneh F, Wang HZ, Wright RC (1986) Magnetic resonance image synthesis. Clinical implementation. Acta Radiol Suppl 369:466–468PubMed
4.
Zurück zum Zitat Warntjes JB, Dahlqvist O, Lundberg P (2007) Novel method for rapid, simultaneous T1, T*2, and proton density quantification. Magn Reson Med: Off JSoc Magn Reson Med/ Soc Magn Reson Med 57(3):528–537. doi:10.1002/mrm.21165 CrossRef Warntjes JB, Dahlqvist O, Lundberg P (2007) Novel method for rapid, simultaneous T1, T*2, and proton density quantification. Magn Reson Med: Off JSoc Magn Reson Med/ Soc Magn Reson Med 57(3):528–537. doi:10.​1002/​mrm.​21165 CrossRef
5.
Zurück zum Zitat Warntjes JB, Leinhard OD, West J, Lundberg P (2008) Rapid magnetic resonance quantification on the brain: optimization for clinical usage. Magn Reson Med: Off J Soc Magn Reson Med / Soc Magn Reson Med 60(2):320–329. doi:10.1002/mrm.21635 CrossRef Warntjes JB, Leinhard OD, West J, Lundberg P (2008) Rapid magnetic resonance quantification on the brain: optimization for clinical usage. Magn Reson Med: Off J Soc Magn Reson Med / Soc Magn Reson Med 60(2):320–329. doi:10.​1002/​mrm.​21635 CrossRef
7.
Zurück zum Zitat Larsson HB, Frederiksen J, Kjaer L, Henriksen O, Olesen J (1988) In vivo determination of T1 and T2 in the brain of patients with severe but stable multiple sclerosis. Magn Res Med: Off J Soc Magn Reson Med / Soc Magn Reson Med 7(1):43–55CrossRef Larsson HB, Frederiksen J, Kjaer L, Henriksen O, Olesen J (1988) In vivo determination of T1 and T2 in the brain of patients with severe but stable multiple sclerosis. Magn Res Med: Off J Soc Magn Reson Med / Soc Magn Reson Med 7(1):43–55CrossRef
8.
Zurück zum Zitat Jackson GD, Connelly A, Duncan JS, Grunewald RA, Gadian DG (1993) Detection of hippocampal pathology in intractable partial epilepsy: increased sensitivity with quantitative magnetic resonance T2 relaxometry. Neurology 43(9):1793–1799CrossRefPubMed Jackson GD, Connelly A, Duncan JS, Grunewald RA, Gadian DG (1993) Detection of hippocampal pathology in intractable partial epilepsy: increased sensitivity with quantitative magnetic resonance T2 relaxometry. Neurology 43(9):1793–1799CrossRefPubMed
9.
Zurück zum Zitat Bernasconi A, Bernasconi N, Caramanos Z, Reutens DC, Andermann F, Dubeau F, Tampieri D, Pike BG, Arnold DL (2000) T2 relaxometry can lateralize mesial temporal lobe epilepsy in patients with normal MRI. NeuroImage 12(6):739–746. doi:10.1006/nimg.2000.0724 CrossRefPubMed Bernasconi A, Bernasconi N, Caramanos Z, Reutens DC, Andermann F, Dubeau F, Tampieri D, Pike BG, Arnold DL (2000) T2 relaxometry can lateralize mesial temporal lobe epilepsy in patients with normal MRI. NeuroImage 12(6):739–746. doi:10.​1006/​nimg.​2000.​0724 CrossRefPubMed
11.
Zurück zum Zitat Mamere AE, Saraiva LA, Matos AL, Carneiro AA, Santos AC (2009) Evaluation of delayed neuronal and axonal damage secondary to moderate and severe traumatic brain injury using quantitative MR imaging techniques. AJNR Am J Neuroradiol 30(5):947–952. doi:10.3174/ajnr.A1477 CrossRefPubMed Mamere AE, Saraiva LA, Matos AL, Carneiro AA, Santos AC (2009) Evaluation of delayed neuronal and axonal damage secondary to moderate and severe traumatic brain injury using quantitative MR imaging techniques. AJNR Am J Neuroradiol 30(5):947–952. doi:10.​3174/​ajnr.​A1477 CrossRefPubMed
14.
Zurück zum Zitat Bonnier G, Roche A, Romascano D, Simioni S, Meskaldji D, Rotzinger D, Lin YC, Menegaz G, Schluep M, Du Pasquier R, Sumpf TJ, Frahm J, Thiran JP, Krueger G, Granziera C (2014) Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis. Ann Clin Transl Neurol 1(6):423–432. doi:10.1002/acn3.68 CrossRefPubMedPubMedCentral Bonnier G, Roche A, Romascano D, Simioni S, Meskaldji D, Rotzinger D, Lin YC, Menegaz G, Schluep M, Du Pasquier R, Sumpf TJ, Frahm J, Thiran JP, Krueger G, Granziera C (2014) Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis. Ann Clin Transl Neurol 1(6):423–432. doi:10.​1002/​acn3.​68 CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Bonnier G, Roche A, Romascano D, Simioni S, Meskaldji DE, Rotzinger D, Lin YC, Menegaz G, Schluep M, Du Pasquier R, Sumpf TJ, Frahm J, Thiran JP, Krueger G, Granziera C (2015) Multicontrast MRI quantification of focal inflammation and degeneration in multiple sclerosis. Biomed Res Int 2015:569123. doi:10.1155/2015/569123 CrossRefPubMedPubMedCentral Bonnier G, Roche A, Romascano D, Simioni S, Meskaldji DE, Rotzinger D, Lin YC, Menegaz G, Schluep M, Du Pasquier R, Sumpf TJ, Frahm J, Thiran JP, Krueger G, Granziera C (2015) Multicontrast MRI quantification of focal inflammation and degeneration in multiple sclerosis. Biomed Res Int 2015:569123. doi:10.​1155/​2015/​569123 CrossRefPubMedPubMedCentral
16.
Metadaten
Titel
Brain imaging with synthetic MR in children: clinical quality assessment
verfasst von
Aaron M. Betts
James L. Leach
Blaise V. Jones
Bin Zhang
Suraj Serai
Publikationsdatum
20.07.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Neuroradiology / Ausgabe 10/2016
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-016-1723-9

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