Introduction
Materials and methods
Subjects
Gabapentin therapy
SPECT protocol and analysis
Pain assessment
Results
Patient disposition
Comparison of regional cerebral blood flow between the fibromyalgia and control groups
κ | Z score | x, mm | y, mm | z, mm | Localization | |
---|---|---|---|---|---|---|
Hyperperfusion | 134 | 4.55 | 66 | -10 | 30 | Right precentral gyrus |
262 | 4.16 | 2 | -62 | 14 | Right posterior cingulate | |
824 | 3.98 | 36 | -82 | 32 | Right superior occipital gyrus | |
429 | 3.95 | 18 | -96 | -6 | Right cuneus | |
220 | 3.57 | 50 | -38 | 52 | Left inferior parietal lobule | |
55 | 3.54 | 52 | -46 | 6 | Right middle temporal gyrus | |
113 | 3.52 | -30 | -42 | 68 | Left postcentral gyrus | |
3.74 | -14 | -74 | 56 | Left superior parietal lobule | ||
709 | 4.66 | -2 | 56 | -22 | Left superior frontal gyrus | |
Hypoperfusion | 1,111 | 4.38 | -12 | -32 | -18 | Left culmen |
Comparison of regional cerebral blood flow among the responder, poor responder, and control groups
Responders | Poor responders | |
---|---|---|
Number | 16 | 13 |
Age, years | 45.3 ± 9.1 | 39.5 ± 12.6 |
Duration of illness, years | 3.0 ± 1.9 | 3.2 ± 2.4 |
Tender points, 0 to 18 | 13.9 ± 2.0 | 15.4 ± 2.8 |
VAS at baseline, 0 to 100 | 81.3 ± 9.6 | 86.9 ± 11.8 |
VAS after gabapentin, 0 to 100 | 15.6 ± 7.3 | 83.1 ± 16.0 |
Dose of gabapentin, milligrams | 2,156.3 ± 427.4 | 2,215.4 ± 450.6 |
κ | Z score | x, mm | y, mm | z, mm | Localization | |
---|---|---|---|---|---|---|
Hyperperfusion | 419 | 4.82 | -24 | -4 | 68 | Left superior frontal gyrus |
169 | 3.80 | -30 | -42 | 68 | Left postcentral gyrus | |
Hypoperfusion | 420 | 4.23 | 2 | 60 | -16 | Right medial frontal gyrus |
2,053 | 4.66 | -44 | -4 | 10 | Left insula | |
420 | 4.23 | -18 | 30 | -24 | Left inferior frontal gyrus | |
258 | 4.38 | -14 | -32 | -14 | Left culmen |
κ | Z score | x, mm | y, mm | z, mm | Localization | |
---|---|---|---|---|---|---|
Hyperperfusion | 253 | 4.87 | 66 | -10 | 34 | Left precentral gyrus |
758 | 4.55 | 2 | -62 | 14 | Right posterior cingulate | |
3,168 | 4.16 | 40 | -76 | 34 | Right precuneus | |
710 | 3.98 | -20 | -8 | 66 | Left middle frontal gyrus | |
1,052 | 3.95 | 54 | -48 | 8 | Right superior temporal gyrus | |
820 | 3.57 | -38 | -88 | -2 | Right middle occipital gyrus | |
201 | 3.52 | 10 | -36 | 82 | Left postcentral gyrus | |
134 | 3.54 | 48 | -42 | 58 | Left inferior parietal lobule | |
Hypoperfusion | 207 | 4.38 | -14 | 36 | -26 | Left orbital gyrus |
κ | Z score | x, mm | y, mm | z, mm | Localization | |
---|---|---|---|---|---|---|
Hyperperfusion | 1,260 | 4.08 | 42 | -62 | 16 | Right middle temporal gyrus |
95 | 3.88 | -46 | 6 | 50 | Left middle frontal gyrus | |
95 | 3.88 | -20 | 38 | 52 | Left superior frontal gyrus | |
69 | 3.67 | 56 | -12 | 56 | Right postcentral gyrus | |
578 | 3.67 | 14 | -76 | 28 | Right precuneus | |
59 | 3.58 | 4 | 20 | 36 | Right cingulate | |
70 | 3.54 | -20 | -80 | 4 | Left middle occipital lobule | |
77 | 3.51 | -20 | -80 | -26 | Left declive |
Localization | Sensitivity, % | Specificity, % | PPV, % | NPV, % |
---|---|---|---|---|
Right middle temporal gyrus | 84.6 | 93.8 | 91.7 | 88.2 |
Left middle frontal gyrus | 84.6 | 81.3 | 78.6 | 86.7 |
Left superior frontal gyrus | 69.2 | 100 | 100 | 80 |
Right postcentral gyrus | 84.6 | 68.8 | 68.8 | 84.6 |
Right precuneus | 76.9 | 100 | 100 | 84.2 |
Right cingulate | 76.9 | 81.3 | 76.9 | 81.3 |
Left middle occipital lobule | 76.9 | 93.8 | 90.9 | 83.3 |
Left declive | 76.9 | 93.8 | 90.9 | 83.3 |