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European Archives of Psychiatry and Clinical Neuroscience

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17.07.2018 | Short Communication

Brain serotonin critically contributes to the biological effects of electroconvulsive seizures

verfasst von: Golo Kronenberg, Markus Petermann, Christof Dormann, Michael Bader, Peter Gass, Rainer Hellweg, Friederike Klempin

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 8/2018

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Abstract

Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2^−/− mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged the start latency in the elevated O-Maze test, an effect that was abolished in Tph2^−/− mice. Furthermore, in the absence of 5-HT, the ECS-induced increase in adult neurogenesis and in brain-derived neurotrophic factor signaling in the hippocampus were significantly reduced. Our results indicate that brain 5-HT critically contributes to the neurobiological responses to ECS.

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Titel: Brain serotonin critically contributes to the biological effects of electroconvulsive seizures
verfasst von: Golo Kronenberg
Markus Petermann
Christof Dormann
Michael Bader
Peter Gass
Rainer Hellweg
Friederike Klempin
Publikationsdatum: 17.07.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 8/2018
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-018-0924-0

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Brain serotonin critically contributes to the biological effects of electroconvulsive seizures

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