Background
Methods
Participants
Disease characteristics
Neuropsychological evaluation
Magnetic resonance imaging (MRI) acquisitions
Volumetric analyses
Tractography seeds
Tractography
Statistical analyses
Results
Population
Variables | MOH patients (n = 14) | Healthy controls (n = 15) | Significance (p) |
---|---|---|---|
Subjects’ characteristics | |||
Age (years) | 45.1 ± 11.2 | 47.5 ± 10.1 | 0.550 |
Sex (F/H) | 10/4 | 12/3 | 0.682 |
Migraine’s characteristics | |||
Migraine duration (years) | 28.5 ± 11.9 | NA | – |
Age of onset of migraine | 16.6 ± 9.3 | NA | – |
Medication Intake (per month) | 59.8 ± 49.0 | NA | – |
Opiates abuse (yes/no) | 4/10 | NA | – |
Caffeine abuse (yes/no) | 3/11 | NA | – |
Prior withdrawal | 3/11 | NA | – |
Neuropsychological evaluation | |||
MDQ-H score | 87.7 ± 25.5 | 21.8 ± 2.1 | <0.001* |
BDI score | 5.4 ± 4.5 | 1.1 ± 1.4 | 0.002* |
STAI score | 40.2 ± 11.2 | 29.8 ± 8.9 | 0.010* |
PCS score | 27.8 ± 12.6 | 5.1 ± 6.3 | <0.001* |
BIS score | 57.1 ± 7.9 | 59.4 ± 7.1 | 0.411 |
IGT score | 25.0 ± 26.3 | 16.0 ± 29.8 | 0.397 |
Regional volumes
Regions | MOH patients (n = 14) | Healthy controls (n = 15) | Significance (p) |
---|---|---|---|
Left side | |||
Infero-lateral ventricle | 0.00038 ± 0.00017 | 0.00025 ± 0.00012 | 0.027 |
Temporal superior gyrus | 0.00112 ± 0.00022 | 0.00129 ± 0.00021 | 0.049 |
Fusiform gyrus | 0.00356 ± 0.00066 | 0.00403 ± 0.00058 | 0.049 |
Occipital middle gyrus | 0.00369 ± 0.00075 | 0.00428 ± 0.00078 | 0.048 |
Frontal middle sulcus | 0.00236 ± 0.00057 | 0.00192 ± 0.00029 | 0.015 |
Right side | |||
Choroid plexus | 0.00119 ± 0.00014 | 0.00135 ± 0.00022 | 0.025 |
Cingular marginalis sulcus | 0.00186 ± 0.00041 | 0.00158 ± 0.00014 | 0.021 |
Hippocampal tractography
MOH patients (n = 14) | Healthy controls (n = 15) | Significance (p) | |
---|---|---|---|
Right hippocampus | |||
Numbers of tracked fibers | 536 ± 297 | 589 ± 263 | 0.605 |
Mean FA | 0.65 ± 0.02 | 0.64 ± 0.03 | 0.746 |
Mean ADC (×1010 m2/s) | 5.00 ± 0.21 | 4.98 ± 0.15 | 0.794 |
Left hippocampus | |||
Numbers of tracked fibers | 473 ± 239 | 660 ± 269 |
0.045*
|
Mean FA | 0.64 ± 0.03 | 0.64 ± 0.03 | 0.795 |
Mean ADC (×1010 m2/s) | 5.01 ± 0.18 | 5.10 ± 0.15 | 0.177 |