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01.04.2012 | Viewpoint | Ausgabe 2/2012

Breast Cancer Research 2/2012

BRCA1 as tumor suppressor: lord without its RING?

Zeitschrift:
Breast Cancer Research > Ausgabe 2/2012
Autoren:
Andrew EH Elia, Stephen J Elledge
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​bcr3118) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Abstract

BRCA1 is a tumor suppressor with critical roles in the maintenance of genomic stability. It encodes a large protein with an amino-terminal RING domain that possesses ubiquitin-ligase activity. Given the occurrence of numerous cancer-causing mutations within its RING domain, investigators have long suspected that BRCA1's ubiquitin ligase is important for its tumor suppression and DNA repair activities. Using genetically engineered mouse models, two recent studies shed light on this age-old hypothesis.

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Authors’ original file for figure 1
13058_2012_2940_MOESM1_ESM.pdf
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