Background
Methods
Subjects
Single nucleotide polymorphism (SNP) selection and genotyping
Statistical analysis
Results
Clinical characteristics of the study population
Indicators | Normal pulse pressure group (n = 438) | High pulse pressure group (n = 460) | P value |
---|---|---|---|
Sex | |||
Males | 275 | 243 | 0.004 |
Females | 163 | 217 | |
Age (year) | 56.94 ± 13.38 | 65.01 ± 11.36 | < 0.001 |
Height (cm) | 164.70 ± 7.51 | 163.36 ± 7.92 | 0.008 |
Weight (kg) | 64.93 ± 11.58 | 66.34 ± 11.40 | 0.065 |
BMI (kg/m2) | 23.88 ± 3.67 | 24.79 ± 3.42 | < 0.001 |
Waist circumference (cm) | 84.87 ± 10.23 | 88.30 ± 9.66 | < 0.001 |
SBP (mmHg) | 138.05 ± 19.64 | 174.93 ± 23.83 | < 0.001 |
DBP (mmHg) | 87.69 ± 17.56 | 93.28 ± 17.31 | < 0.001 |
PP (mmHg) | 50.36 ± 8.14 | 81.65 ± 16.16 | < 0.001 |
Obesity (%) | 156 (35.62) | 244 (53.04) | < 0.001 |
Diabetes (%) | 103 (23.52) | 198 (43.04) | < 0.001 |
Smoking (%) | |||
Smoker | 275 (62.79) | 324 (70.43) | < 0.001 |
Former-smokers | 118 (26.94) | 71 (15.44) | |
Nonsmoker | 45 (10.27) | 65 (14.13) | |
Drinking (%) | 63 (14.38) | 38 (8.26) | 0.005 |
Associations between BRD4 and PIN1 SNPs and high PP
SNPs | Genotypes and alleles | Frequencies N (%) | P value | |
---|---|---|---|---|
Case (n = 460) | Control (n = 438) | |||
AA | 250 (0.543) | 240 (0.548) | 0.046878 | |
BRD4 | AT | 164 (0.357) | 173 (0.395) | |
rs4808278 | TT | 46 (0.100) | 25 (0.057) | |
Allele, T (%) | 256 (0.278) | 223 (0.255) | 0.256363 | |
GG | 443 (0.963) | 418 (0.954) | 0.511810 | |
PIN1 | CG | 17 (0.037) | 20 (0.046) | |
rs2233678 | CC | 0 (0) | 0 (0) | |
Allele, C (%) | 17 (0.018) | 20 (0.023) | 0.516271 | |
GG | 438 (0.952) | 422 (0.963) | 0.400651 | |
PIN1 | AG | 22 (0.048) | 16 (0.037) | |
rs2233682 | AA | 0 (0) | 0 (0) | |
Allele, A(%) | 22 (0.024) | 16 (0.018) | 0.405751 | |
CC | 225 (0.489) | 232 (0.530) | 0.476216 | |
PIN1 | CT | 184 (0.400) | 162 (0.370) | |
rs2287838 | TT | 51 (0.111) | 44 (0.100) | |
Allele, T (%) | 286 (0.311) | 250 (0.285) | 0.238116 |
Haplotype analyses of BRD4 and PIN1 SNPs
GMDR analysis of BRD4 and PIN1 SNPs and high PP risk
Locus no | Best combination | Cross-validation consistency | Testing accuracy | P values |
---|---|---|---|---|
SNP-SNP interactionsa | ||||
2 | rs2233682, rs4808278 | 8/10 | 0.5093 | 0.1719 |
3 | rs2233678, rs2233682, rs4808278 | 7/10 | 0.4991 | 0.1719 |
Gene-diabetes interactionsb | ||||
2 | rs4808278, diabetes | 10/10 | 0.5783 | 0.0107 |
3 | rs2233678, rs4808278, diabetes | 9/10 | 0.5747 | 0.0107 |